CN119258136A

CN119258136A - Application of Chinese medicine composition in preparing medicine for relieving cough and reducing phlegm

Info

Publication number: CN119258136A
Application number: CN202410785042.4A
Authority: CN
Inventors: 肖伟; 李贵平; 李芳�; 董雪红; 李良; 曹亮; 王振中
Original assignee: Jiangsu Kanion Pharmaceutical Co Ltd
Current assignee: Jiangsu Kanion Pharmaceutical Co Ltd
Priority date: 2024-06-18
Filing date: 2024-06-18
Publication date: 2025-01-07

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to application of a traditional Chinese medicine composition in preparation of a medicine for relieving cough and reducing sputum. The traditional Chinese medicine composition comprises 5-30 parts of cordate houttuynia, 5-30 parts of honeysuckle, 5-20 parts of red paeony root, 3-15 parts of mugwort leaf and 3-15 parts of peppermint. The invention discovers that the composition can obviously prolong the cough latency of mice caused by ammonia water spraying, reduce the cough times of the mice, obviously improve the phenol red content in the mice broncholavage liquid and increase the phlegm-resolving rate, and shows that the traditional Chinese medicine composition has the effects of relieving cough and resolving phlegm.

Description

Application of traditional Chinese medicine composition in preparation of cough relieving and phlegm reducing medicines

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to application of a traditional Chinese medicine composition in preparation of a medicine for relieving cough and reducing sputum.

Background

Sputum is mucus secreted by respiratory tract, and can be discharged by cough, so that the self-cleaning and smooth respiratory tract can be maintained, and excessive sputum is a common symptom of respiratory tract diseases. If the sputum cannot be discharged, not only the disease is difficult to cure, but also the respiratory tract is easy to be blocked, so that the respiratory disorder is caused, and the serious patient causes dyspnea to endanger life.

Cough is also a common symptom of respiratory tract, and is caused by inflammation, foreign matter, physical or chemical stimulation of trachea, bronchus mucosa or pleura, and is characterized by glottis closure, respiratory muscle contraction, rise of internal pulmonary pressure, glottis opening and air injection in the lung, and the cough can comprise wet cough, dry cough, allergic cough and the like.

The cause of cough is various and mainly includes environmental factors that when the temperature of the surrounding environment is reduced, cold air is inhaled to cause cough. Meanwhile, irritant gases such as automobile exhaust, sulfur dioxide and the like may irritate bronchi, resulting in cough. Cough is closely related to respiratory tract infection, including bacterial, viral, mycoplasma, etc. These infections can cause acute or chronic bronchitis, leading to the appearance of cough symptoms. Allergy inhalation of allergic substances such as pollen, dander, dust, etc. may also lead to cough. In addition, food allergy is an important cause, and especially infants are liable to produce allergic reactions to foods such as fish, shrimp and crab, eggs, milk, etc. Climate change, changes in air temperature, air pressure and ions in the air can induce coughing. Cough is relatively high in incidence during cold seasons or in autumn and winter. Mental factors such as agitation, tension, complaints of anger, etc. may also contribute to cough attacks. Exercise, some patients may induce cough after strenuous exercise, which is called exercise-induced cough or exercise-induced cough. Drug factors certain drugs such as angiotensin converting inhibitors (e.g. enalapril, benazepril) and propranolol may cause cough as an adverse reaction.

At present, the common cough relieving medicines comprise Chinese medicines and western medicines, and the western medicines have the characteristics of definite target and quick response. Western medicines generally contain fewer components, have the main effects of eliminating phlegm, resisting allergy and dilating bronchi, and can rapidly relieve cough symptoms. However, western medicines have some disadvantages, such as more side effects, and some medicines may cause adverse reactions such as somnolence, headache, nausea and the like. In addition, western medicines can rapidly relieve symptoms, but cannot fundamentally solve the cause of cough, and repeated cough can occur. The traditional Chinese medicine has small relative side effect and is safer to take for a long time. However, most of cough-relieving traditional Chinese medicine components on the market at present are very complex and have an insufficient and definite effect. In recent years, along with the deep research of medicine, the scheme for treating cough and excessive phlegm is also evolving continuously, and the field of traditional Chinese medicine is actively involved in the work of relieving cough and eliminating phlegm, so that a symptomatic prescription is developed.

Disclosure of Invention

In view of the above, the technical problem to be solved by the invention is to provide the application of the traditional Chinese medicine composition in preparing the drugs for relieving cough and reducing sputum.

The invention provides application of a traditional Chinese medicine composition in preparing a medicament for relieving cough and/or reducing phlegm;

The traditional Chinese medicine composition comprises, by mass, 5-30 parts of cordate houttuynia, 5-30 parts of honeysuckle, 5-20 parts of red paeony root, 3-15 parts of mugwort leaf and 3-15 parts of peppermint.

In the present invention, the cough relief includes reducing the number of cough and/or extending the cough latency.

The incubation period of cough refers to the period of time between the onset of symptoms of cough and the onset of symptoms of cough after physical contact causes of cough. The duration of this period reflects the effectiveness of the drug on the body. The extended incubation period of cough indicates that the administered drug is effective. The results of the embodiment of the invention show that the times of cough can be effectively reduced by the administration of the traditional Chinese medicine composition, and the time of cough after the mice receive the stimulus can be prolonged.

In the invention, the phlegm reduction comprises the step of improving the secretion amount of the sputum.

Sputum mainly consists of gland secretion, necrotic tissues, bacteria, foreign matters and the like in the airway, and when the respiratory tract is stimulated or infected, the secretion amount of the sputum increases. The phlegm reduction means that the body is helped to discharge the phlegm accumulated in the respiratory tract by a series of methods, so that the symptoms of cough, unsmooth breathing and the like are relieved. According to the invention, the phenol red test shows that the administration of the traditional Chinese medicine composition is beneficial to improving the secretion of sputum and plays a role in resolving phlegm.

There are many factors that cause cough, which in the present invention is caused by the stimulating gas. In a specific embodiment, the irritating gas is ammonia gas and/or ammonia water spray.

In the embodiment of the invention, the traditional Chinese medicine composition comprises, by mass, 5-25 parts of cordate houttuynia, 5-25 parts of honeysuckle, 5-15 parts of red paeony root, 3-10 parts of mugwort leaf and 3-10 parts of peppermint. Further, the traditional Chinese medicine composition comprises, by mass, 15-25 parts of cordate houttuynia, 15-25 parts of honeysuckle, 10-15 parts of red paeony root, 5-10 parts of mugwort leaf and 3-5 parts of peppermint.

Optionally, the traditional Chinese medicine composition comprises 20 parts of cordate houttuynia, 20 parts of honeysuckle, 12 parts of red paeony root, 8 parts of mugwort leaf and 4 parts of peppermint in parts by mass.

Optionally, the traditional Chinese medicine composition comprises 15 parts of cordate houttuynia, 15 parts of honeysuckle, 12 parts of red paeony root, 7 parts of mugwort leaf and 7 parts of peppermint in parts by mass.

Optionally, the traditional Chinese medicine composition comprises, by mass, 10 parts of cordate houttuynia, 10 parts of honeysuckle, 8 parts of red paeony root, 4 parts of mugwort leaf and 4 parts of peppermint.

The composition of the present invention may be directly pulverized, or may be an extract obtained by conventional means in the art, etc. The composition can be directly ground into powder according to the traditional method, or can be prepared into extracts through the conventional method so as to be prepared into different dosage forms, so that the composition has better curative effect and is more beneficial to preparing modern pharmaceutical dosage forms.

In the embodiment of the invention, the preparation method of the traditional Chinese medicine composition comprises the following steps:

step A, weighing traditional Chinese medicinal materials according to the weight proportion of the raw materials;

step B, extracting the honeysuckle with 6-12 times of 50% -80% ethanol, filtering the extracting solution, recovering the ethanol, drying and crushing to obtain dry paste powder;

Extracting volatile oil from herba houttuyniae, folium artemisiae argyi and mint by adding 3-12 times of water, adding red paeony root coarse powder into dregs, adding 6-12 times of water for decoction, filtering an extracting solution to obtain clear paste, adding ethanol with the concentration of more than 90% until the ethanol content is 60% -80%, precipitating with ethanol, standing, recovering ethanol from supernatant fluid to obtain thick paste, drying and crushing to obtain dry paste powder;

and D, mixing the volatile oil and the two dry paste powders.

Further, the preparation method of the traditional Chinese medicine composition comprises the following steps:

Step A, adding 12 times of 50% ethanol into honeysuckle, extracting under reflux for two times, each time for 0.5 hour, filtering, combining filtrate, recovering ethanol under reduced pressure, concentrating into thick paste with the relative density of 1.20-1.25, drying under reduced pressure, and crushing to obtain ethanol extract partial dry extract powder;

Step B, adding 8 times of water into the cordate houttuynia, the mugwort leaf and the mint, extracting volatile oil by steam distillation for 5 hours, and filtering an extracting solution for later use;

Step C, grinding and clathrating the obtained volatile oil with 10 times of beta-cyclodextrin and 20 times of water for 20 minutes, drying the clathrate, and pulverizing to obtain volatile oil clathrate;

And D, mixing the residues with red paeony root after extracting volatile oil, adding 10 times of water, extracting twice, mixing the extracting solution with the oil extraction liquid medicine for 1 hour each time, filtering, concentrating the filtrate under reduced pressure to obtain clear paste with the relative density of 1.02-1.05, cooling to room temperature, adding 95% ethanol to ensure that the ethanol content reaches 70%, standing for more than 12 hours, recovering ethanol from the supernatant fluid after ethanol precipitation under reduced pressure, concentrating to obtain thick paste with the relative density of 1.25-1.30, drying under reduced pressure, crushing to obtain water extract part dry extract powder, and mixing the ethanol extract part dry extract powder, the volatile oil inclusion compound and the water extract part dry extract powder.

The invention also provides a medicament for relieving cough and reducing sputum, which comprises pharmaceutically acceptable auxiliary materials and raw materials including, by mass, 5-30 parts of cordate houttuynia, 5-30 parts of honeysuckle, 5-20 parts of red paeony root, 3-15 parts of mugwort leaf and 3-15 parts of peppermint.

Dosage forms of the medicament of the invention include, but are not limited to, decoction, granules, capsules, tablets, oral liquid, pills, tinctures, syrups, suppositories, gels, sprays and/or injections.

In some embodiments provided herein, the capsule is a hard capsule or a soft capsule.

In some embodiments provided herein, the tablet is an oral tablet or a buccal tablet.

Oral tablets refer to tablets intended for oral administration, and most of these tablets are intended to be absorbed by the gastrointestinal tract and some of these tablets are intended to be locally active in the gastrointestinal tract. In some embodiments provided herein, the oral tablet is a compressed tablet, dispersible tablet, effervescent tablet, chewable tablet, coated tablet, or sustained-release tablet.

The pharmaceutically acceptable auxiliary materials comprise one or more of fruit powder, edible essence, sweetener, acidulant, filler, lubricant, preservative, suspending agent, food color, diluent, emulsifier, disintegrating agent or plasticizer.

The medicine also comprises other medicines for relieving cough and reducing sputum, wherein the other medicines for relieving cough and reducing sputum comprise at least one of dextromethorphan guaifenesin, ambroxol hydrochloride, fudosteine, bromhexine hydrochloride, acetylcysteine, benproperine phosphate, carbocisteine and ammonium chloride.

In the present invention, the Chinese medicinal composition and the other therapeutic agent may exist independently of each other or may exist in combination, which is not limited in the present invention.

Still further, the present invention provides a method of relieving cough and reducing sputum comprising administering the medicament of the present invention.

The administration modes of the medicine include but are not limited to oral administration, spray inhalation, rectal administration, nasal administration, buccal administration, vaginal administration and topical administration. Or parenterally, for example subcutaneously, intravenously, intramuscularly, intraperitoneally, intrathecally, intraventricularly, intrasternally or intracranially, or by means of an explanted reservoir. Preferably, the administration is oral and/or aerosol inhalation.

In the present invention, in the case where the medicine includes a Chinese medicinal composition and other therapeutic agents, two or more medicines may be administered simultaneously or sequentially, which is not limited in the present invention.

For example, the traditional Chinese medicine composition in the drug is administered no longer than 6 hours, preferably no longer than 5 hours, more preferably no longer than 4 hours, even more preferably no longer than 3 hours, more preferably no longer than 2 hours and most preferably no longer than 1 hour before the administration of the other therapeutic agent and/or no longer than 6 hours, preferably no longer than 5 hours, more preferably no longer than 4 hours, even more preferably no longer than 3 hours, more preferably no longer than 2 hours and most preferably no longer than 1 hour after the administration of the other therapeutic agent.

In the present invention, in the case where the medicine includes a Chinese medicinal composition and other therapeutic agents, the administration frequency of two or more medicines may be the same or different, and the present invention is not limited thereto.

For example, the frequency of administration of two or more of the agents is independently selected from 4 times/day, 3 times/day, 2 times/day, or 1 time/day, wherein the frequency of administration of the traditional Chinese medicine composition is 4 times/day, 3 times/day, 2 times/day, or 1 time/day.

In the invention, the medicine comprises a traditional Chinese medicine composition, and the administration dosage is not lower than the effective dosage. The medicine comprises a traditional Chinese medicine composition and other therapeutic agents, wherein the administration dosage of the traditional Chinese medicine composition is lower than or not lower than the effective dosage, and the administration dosage of the other therapeutic agents is lower than or not lower than the effective dosage.

In the present invention, an effective dose includes a "therapeutically effective amount" or a "prophylactically effective amount" that is, within the scope of sound medical judgment, an amount sufficient to treat or prevent the disease of the patient but low enough to avoid serious side effects (at a reasonable benefit/risk ratio). The prophylactically or therapeutically effective amount of the drug will vary depending upon factors selected for the particular drug (e.g., taking into account efficacy, effectiveness, and half-life of the drug), the route of administration selected, the disease being prevented or treated, the severity of the disease being prevented or treated, the age, size, weight, and physical condition of the patient being prevented or treated, the medical history of the patient being prevented or treated, the duration of prevention or treatment, the nature of concurrent therapy, the effect of prevention or treatment desired, and the like, but can still be routinely determined by one of ordinary skill in the art.

In the invention, the prevention and treatment comprise prevention and/or treatment, and are prevention and treatment measures aiming at cough and excessive phlegm. This includes methods of preventing the occurrence of cough with the objective of preventing, slowing (reducing) unwanted physiological changes or lesions in a subject, beneficial or desired clinical results including, but not limited to, avoiding the occurrence of cough sputum, alleviation of symptoms of cough sputum, diminishment of cough sputum, stabilization (i.e., not worsening) of cough sputum status, delay or slowing of cough progression, amelioration or palliation of cough sputum status, and remission (whether partial or complete), whether detectable or undetectable. Subjects in need of treatment include subjects already with the condition or disease and subjects prone to the condition or disease or subjects intended to prevent the condition or disease.

In the present invention, the subject to be controlled is a human or a mammal, and the mammal includes bovine, equine, ovine, porcine, canine, feline, rodent, primate. The rodent is a mouse and/or a rat.

The traditional Chinese medicine composition comprises 5-30 parts of cordate houttuynia, 5-30 parts of honeysuckle, 5-20 parts of red paeony root, 3-15 parts of mugwort leaf and 3-15 parts of peppermint. The invention discovers that the composition can obviously prolong the cough latency of mice caused by ammonia water spraying, reduce the cough times of the mice, obviously improve the phenol red content in the mice broncholavage liquid and increase the phlegm-resolving rate, and shows that the traditional Chinese medicine composition has the effects of relieving cough and resolving phlegm.

Detailed Description

The invention provides application of a traditional Chinese medicine composition in preparing a medicament for relieving cough and reducing sputum, and a person skilled in the art can properly improve technological parameters by referring to the content of the invention. It is expressly noted that all such similar substitutions and modifications will be apparent to those skilled in the art, and are deemed to be included in the present invention. While the methods and applications of this invention have been described in terms of preferred embodiments, it will be apparent to those skilled in the relevant art that the invention can be practiced and practiced with modification and alteration and combination of the methods and applications herein without departing from the spirit and scope of the invention.

The test materials adopted by the invention are all common commercial products and can be purchased in the market.

The following experiments were carried out under conventional conditions or conditions suggested by the manufacturer, and the raw materials or auxiliary materials and the reagents or instruments used were conventional products available commercially, unless the specific conditions were noted. All percentages, ratios, proportions or parts are by weight unless otherwise indicated.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. In addition, any methods and materials similar or equivalent to those described can be used in the practice of the present invention. The invention is further illustrated by the following examples:

EXAMPLE 1 preparation of a Chinese medicinal composition

The raw materials comprise 750g of cordate houttuynia, 750g of honeysuckle, 450g of red peony root, 300g of mugwort leaf and 150g of peppermint.

Adding 12 times of 50% ethanol into honeysuckle, reflux-extracting for two times each for 0.5 hour, filtering, combining the filtrates, recovering ethanol under reduced pressure (-0.07 MPa to-0.09 MPa, 65-75 ℃) and concentrating to thick paste with the relative density of 1.20-1.25 (65 ℃), drying under reduced pressure (-0.07 MPa to-0.09 MPa, 60-65 ℃), and crushing to obtain ethanol extract partial dry extract powder;

step B, adding 8 times of water into the cordate houttuynia, the mugwort leaf and the mint, distilling the mixture by water vapor to extract volatile oil, extracting for 5 hours, filtering an extracting solution, and storing the extracting solution in another container for later use;

step C, grinding and clathrating the obtained volatile oil with 10 times of beta-cyclodextrin and 20 times of water for 20 minutes, drying the clathrate (55 ℃) and crushing to obtain a volatile oil clathrate;

And D, mixing the residues with red paeony root after extracting volatile oil, adding 10 times of water, extracting for two times, mixing the extracting solution with the oil extraction liquid medicine each time for 1 hour, filtering, concentrating the filtrate under reduced pressure (-0.07 MPa to-0.09 MPa,75 ℃ to 85 ℃) to obtain clear paste with the relative density of 1.02 to 1.05 (70 ℃), cooling to room temperature, adding 95% ethanol to ensure that the ethanol content reaches 70%, standing for more than 12 hours, recovering ethanol from the supernatant under reduced pressure (-0.07 MPa to-0.09 MPa,65 ℃ to 75 ℃) and concentrating to obtain thick paste with the relative density of 1.25 to 1.30 (65 ℃), adding a proper amount of dextrin under reduced pressure (-0.07 MPa to-0.09 MPa,75 ℃) for drying, and crushing to obtain dry extract powder of an aqueous extract part.

Mixing the above three intermediates (ethanol extract dry extract powder, volatile oil clathrate, and water extract dry extract powder) with dextrin and steviosin, granulating by dry method, and making into 1000g granule.

EXAMPLE 2 Effect of Chinese medicinal composition on cough in mice caused by Ammonia spraying

Experimental materials

Animals, ICR 70 mice, SPF grade, body weight 18-22g, male and female halves.

The medicine is dextromethorphan guaifenesin syrup, shanghai Qiangsheng pharmaceutical Co., ltd., batch number 221206234, and the specification is 150 mL/bottle.

Reagent ammonia water, nanjing chemical reagent Co., ltd., batch number 181022827K, specification 500 mL/bottle.

The instrument comprises a BS224S type electronic analytical balance, an ACX-SC-DA type animal weighing scale, shanghai Xiangchuan electronic weighing apparatus, a YLS-8A multifunctional cough and asthma inducing instrument and Shanghai Xin Soft information technology, inc.

Experimental method

Taking 70 ICR mice, preselecting the male and female mice, putting the mice into a YLS-8A multifunctional cough and asthma inducing instrument, adding ammonia water into an atomizing cup for about 20mL, spraying for 5 seconds, stopping spraying, and observing and recording the time (cough latency period) required by causing the cough of the mice and the times of the cough within 1 min. If the cough latency is less than 1min and more than 3 times of typical cough appear in 1min, the animal is sensitive to cough, otherwise, the animal is eliminated without cough.

The qualified mice are randomly divided into 5 groups, namely a model control group (pure water), a positive control group (dextromethorphan guaifenesin syrup, 12.3 mL/kg), and low, medium and high dose groups (7.38, 14.76 and 29.52g crude drug/kg) of the traditional Chinese medicine composition, wherein each group comprises 10 male and female halves. Each group of mice was given an equivalent volume of purified water by gavage, 1 time daily, for 5 consecutive days. After the last administration for 1h, the mice are put into a YLS-8A multifunctional cough and asthma inducing instrument, ammonia water is added into an atomizing cup for about 20mL, spraying is stopped for 5s, and the incubation period of the cough and the cough times of 3min of the mice are observed and recorded. Cough is marked by contraction of abdominal muscles and simultaneous opening of large mouth, sometimes with cough.

The results show that compared with a model control group, the low, medium and high dosage groups of the traditional Chinese medicine composition and the positive control medicine dextromethorphan guaifenesin syrup group can obviously prolong the cough latency period of mice cough caused by ammonia water spraying and reduce the cough frequency of the mice (P <0.05 and P < 0.01). The results are shown in Table 1.

TABLE 1 influence on cough in mice caused by ammonia sprayn=10)

Note that P <0.05, P <0.01 compared to model control.

Experimental example 3 Effect of Chinese medicinal composition on discharge of phenol Red from mice

Experimental materials

Animals, ICR 50 mice, SPF grade, body weight 18-22g, male and female halves.

The medicine is ambroxol hydrochloride oral solution, beijing S. Korea and the USA medicine Co., ltd., batch number 22110002, specification 120 mL/bottle.

The reagent comprises phenol red, aba Ding Gongsi, batch No. 130370, specification 100 mg/bottle, sodium bicarbonate, aba Ding Gongsi, batch No. 20220111, specification 500 g/bottle.

The instrument comprises a BS224S type electronic analytical balance, an ACX-SC-DA type animal weighing scale, shanghai Xiangchuan electronic weighing apparatus, a Flexstation3 multifunctional enzyme-labeled instrument and an American MD company.

Experimental method

50 ICR mice with the weight of 18-22 g are selected, each half of the ICR mice is randomly divided into 5 groups according to the weight, namely a blank control group (pure water), a positive control group (ambroxol hydrochloride oral solution, 6.15 mL/kg), and low, medium and high dosage groups (7.38, 14.76 and 29.52g crude drugs/kg) of the traditional Chinese medicine composition, wherein each group comprises 10 female half and male half. Each group was given the corresponding drug by gavage, and the blank group was given an equal volume of pure water 1 time a day for 7 consecutive days. No water was forbidden for 16h before the experiment. 1h after the last administration, a 5% phenol red solution (w/v, physiological saline, 10 mL/kg) was administered by one-time lavage. After phenol red administration, mice were sacrificed at 30min intervals, the trachea between the thyroid cartilage and the main bronchus was taken, about 1mL of 5% NaHCO3 physiological saline solution was added, and after 15min of ultrasound, the mice were placed in a Flexstation 3 multifunctional microplate reader at 546nm to determine the OD value of absorbance. Meanwhile, 5% of NaHCO3 physiological saline solution is used for respectively obtaining 10, 5,2.5, 1, 0.5, 0.25 and 0.1 mug/mL of NaHCO3 physiological saline solution by a double dilution method, a sample is taken and the absorbance OD value at 546nm is measured, a phenol red standard curve is drawn, and the phenol red amount and the phlegm reduction rate are calculated according to a standard curve regression equation. Phlegm reduction rate (%) =phenol red content in the control group tracheal lavage fluid/phenol red content in the administration group tracheal lavage fluid x 100%.

The results show that compared with the blank control group, the low, medium and high dosage groups of the traditional Chinese medicine composition and the positive control drug ambroxol hydrochloride oral solution group can obviously improve the phenol red amount (P < 0.01) in the mouse bronchus lavage fluid and increase the phlegm reduction rate. The results are shown in Table 2.

TABLE 2 influence on the discharge of phenol red from the tracheal segment of micen=10)

Note that P <0.05, P <0.01 compared to the placebo group.

The traditional Chinese medicine composition provided by the invention can obviously prolong the cough latency of mice caused by ammonia water spraying, reduce the cough times of the mice, obviously improve the phenol red content in the mice broncholavage liquid and increase the phlegm reduction rate.

The foregoing is merely a preferred embodiment of the present invention and it should be noted that modifications and adaptations to those skilled in the art may be made without departing from the principles of the present invention, which are intended to be comprehended within the scope of the present invention.

Claims

1. The application of the traditional Chinese medicine composition in preparing medicines for relieving cough and/or reducing phlegm;

2. The use according to claim 1, wherein the cough relief comprises a reduction in the number of coughs and/or an extension of cough latency.

3. The use according to claim 1, wherein said reducing sputum comprises increasing sputum secretion.

4. The use according to any one of claims 1 to 3, wherein the cough is a cough caused by a stimulating gas.

5. The use according to any one of claims 1 to 4, wherein the irritant gas is ammonia and/or ammonia spray.

6. The use according to any one of claims 1 to 5, wherein the method for preparing the traditional Chinese medicine composition comprises:

and D, mixing the volatile oil and the two dry paste powders.

7. The use according to claim 6, wherein the method of preparing the Chinese medicinal composition comprises the steps of:

8. The medicament for relieving cough and reducing sputum comprises pharmaceutically acceptable auxiliary materials and raw materials including, by mass, 5-30 parts of cordate houttuynia, 5-30 parts of honeysuckle, 5-20 parts of red paeony root, 3-15 parts of mugwort leaf and 3-15 parts of peppermint.

9. The medicine according to claim 8, further comprising other antitussive and expectorant medicines, wherein the other antitussive and expectorant medicines comprise at least one of dextromethorphan guaifenesin, ambroxol hydrochloride, fudosteine, bromhexine hydrochloride, acetylcysteine, benproperine phosphate, carbocisteine, and ammonium chloride.