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CN119257247A - Lutein ester and/or zeaxanthin eye protection composition and preparation method and application thereof - Google Patents

Lutein ester and/or zeaxanthin eye protection composition and preparation method and application thereof Download PDF

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Publication number
CN119257247A
CN119257247A CN202411685830.2A CN202411685830A CN119257247A CN 119257247 A CN119257247 A CN 119257247A CN 202411685830 A CN202411685830 A CN 202411685830A CN 119257247 A CN119257247 A CN 119257247A
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China
Prior art keywords
zeaxanthin
eye
vitamin
lutein ester
lutein
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CN202411685830.2A
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Chinese (zh)
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秦逸潇
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Individual
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

本发明公开了叶黄素酯和/或玉米黄质的护眼组合物及制备方法和应用，具体涉及营养剂制备技术领域，包括叶黄素酯和/或玉米黄质、维生素C、蓝莓粉、D‑甘露糖醇、虾青素、维生素E、硒、谷胱甘肽和乳铁蛋白；本发明通过采用高纯度叶黄素酯和/或玉米黄质作为主要活性成分，并结合多种辅助成分；本发明提出的植物护眼组合物能够显著提高护眼效果，有效预防和改善流泪、晶状体、黄斑病变等眼部健康问题，并且通过纳米分散和微囊化技术的结合，将叶黄素酯和/或玉米黄质分散至纳米级，并通过壁材包裹形成微胶囊，不仅提高了其稳定性和溶解度，还延长了活性成分在体内的滞留时间，从而增强了护眼作用的持久性。

The invention discloses an eye protection composition of lutein ester and/or zeaxanthin, a preparation method and application thereof, and specifically relates to the technical field of nutrient preparation, including lutein ester and/or zeaxanthin, vitamin C, blueberry powder, D-mannitol, astaxanthin, vitamin E, selenium, glutathione and lactoferrin; the invention adopts high-purity lutein ester and/or zeaxanthin as main active ingredients, and combines multiple auxiliary ingredients; the plant eye protection composition proposed by the invention can significantly improve the eye protection effect, effectively prevent and improve eye health problems such as tearing, lens, and macular degeneration, and through the combination of nano-dispersion and microencapsulation technology, the lutein ester and/or zeaxanthin are dispersed to the nano-scale, and are wrapped by wall materials to form microcapsules, which not only improves the stability and solubility thereof, but also prolongs the retention time of the active ingredients in the body, thereby enhancing the durability of the eye protection effect.

Description

Eye protection composition of lutein ester and/or zeaxanthin, preparation method and application
Technical Field
The invention relates to the technical field of nutrient preparation, in particular to an eye protection composition of lutein ester and/or zeaxanthin, a preparation method and application thereof.
Background
With modern lifestyle changes, pets, like humans, are increasingly exposed to environmental factors during daily activities, especially the effects of solar ultraviolet rays during outdoor activities, which pose new challenges to their ocular health, combined with stress, genetic factors and nutritional intake considerations, which act together with the ocular health of pets to increase, for example, tear, lens changes and age-related ocular diseases. Traditionally, some basic nutritional ingredients such as vitamins A, C, E may also be added to pet foods to support eye health, but these ingredients have limitations in improving eye protection performance.
Lutein esters and zeaxanthin, two components naturally found in the macular region of the eye, are also critical for pets. The anti-oxidation agent not only has strong anti-oxidation capability, but also can effectively resist damage of eye free radicals, and can help filter harmful blue light, reduce damage of the light to eyes, thereby maintaining eye health of pets. Unfortunately, the purity of lutein esters and zeaxanthin in eye protection products currently on the market for pets is often insufficient, which directly limits the protective effect on the eyes of pets.
In view of this, we propose lutein ester and/or zeaxanthin eye-protecting compositions specifically designed for pets and methods for preparing the same, aiming at more effectively promoting eye health of pets by improving purity and bioavailability of these key ingredients.
Disclosure of Invention
The invention aims to provide an eye protection composition of lutein ester and/or zeaxanthin, a preparation method and application thereof, so as to solve the defects in the technology.
In order to achieve the aim, the invention provides the technical scheme that the eye protection composition of lutein ester and/or zeaxanthin comprises lutein ester and/or zeaxanthin, vitamin C, blueberry powder, D-mannitol, astaxanthin, vitamin E, selenium, glutathione and lactoferrin.
Preferably, the purity of lutein ester and/or zeaxanthin is not less than 98%.
Preferably, the content of vitamin C is 5% -15%, the content of blueberry powder is 5% -20%, the content of D-mannitol is 10% -30%, the content of astaxanthin is 5% -15%, the content of vitamin E is 1% -5%, the content of selenium is 0.01% -0.1%, the content of glutathione is 0.1% -1%, and the content of lactoferrin is 0.5% -2%.
Preferably, the lutein ester and/or zeaxanthin have an average particle size of less than 100nm.
The application of the eye protection composition in protecting eye health comprises oral liquid, capsule and powder.
A method of preparing an eye care composition comprising the steps of:
S1, extracting lutein ester and/or zeaxanthin from natural plants, performing primary purification by a first preset method, and then improving the purity of lutein ester and/or zeaxanthin to not lower than 98% by a second preset method;
S2, mixing the purified lutein ester and/or zeaxanthin with a proper amount of surfactant to form a uniform solution, dispersing the lutein ester and/or zeaxanthin solution to a nano level by using preset equipment, controlling the average particle diameter below 100 nanometers, and preparing other auxiliary components;
s3, uniformly mixing the nano lutein ester and/or zeaxanthin solution with other auxiliary components such as vitamin C, blueberry powder, D-mannitol, astaxanthin, vitamin E, selenium, glutathione and lactoferrin according to a predetermined proportion, selecting a wall material, mixing the wall material with the mixed solution, and coating the wall material in a preset drying manner to form microcapsules or powder;
S4, adding a controlled release material in the preparation process of the microcapsule to enable the microcapsule to slowly release active ingredients under preset time or conditions, and enabling the microcapsule to accurately reach eye tissues through surface modification or addition of targeting molecules;
s5, customizing an oral liquid according to a dosage scheme and a dosage form, wherein the oral liquid takes honey as a carrier.
Preferably, in S1, the first preset method includes solvent extraction, column chromatography or crystallization, and the second preset method includes high performance liquid chromatography HPLC or supercritical fluid extraction SFE.
Preferably, the auxiliary components comprise vitamin C, blueberry powder, D-mannitol, astaxanthin, vitamin E, selenium, glutathione and lactoferrin, wherein the vitamin E is oily or powdery, and the selenium exists in the form of inorganic salt or organic compound.
Preferably, the preset device comprises a high-pressure homogenizer or an ultrasonic disperser.
Preferably, the preset drying mode comprises spray drying, freeze drying or agglomeration.
In the technical scheme, the invention has the technical effects and advantages that:
The eye protection composition provided by the invention can obviously improve the eye protection effect by adopting the high-purity lutein ester and/or zeaxanthin as main active ingredients and combining various auxiliary ingredients, effectively prevent and improve eye health problems such as lacrimation, crystalline lens, maculopathy and the like, and the lutein ester and/or zeaxanthin are dispersed to the nanoscale by combining the nano dispersion and microencapsulation technology and are encapsulated by wall materials to form microcapsules, so that the stability and the solubility of the lutein ester and/or zeaxanthin are improved, the residence time of the active ingredients in the body is prolonged, the durability of the eye protection effect is enhanced, the controlled release material is introduced, the active ingredients can be slowly released under specific time or condition, and the active ingredients can be ensured to accurately reach eye tissues by surface modification or addition of targeting molecules, so that the accurate eye protection is realized.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for the embodiments will be briefly described below, and it is apparent that the drawings in the following description are only some embodiments described in the present application, and other drawings may be obtained according to these drawings for a person having ordinary skill in the art.
FIG. 1 is a flow chart of the present invention.
Detailed Description
In order to make the technical scheme of the present invention better understood by those skilled in the art, the present invention will be further described in detail with reference to the accompanying drawings.
The invention provides the following technical scheme, as shown in figure 1:
Example 1:
raw material preparation:
Lutein ester is extracted from marigold, primary purification is carried out by a solvent extraction method, and the purity of lutein ester is improved to 98.5% by High Performance Liquid Chromatography (HPLC).
Vitamin C powder, blueberry powder (containing natural anthocyanin), D-mannitol, astaxanthin, oily vitamin E, inorganic selenium compound, glutathione and lactoferrin with purity of 99% are selected.
Nanocrystallization:
Mixing the purified lutein ester with appropriate amount of surfactant (such as Tween 80) to form uniform solution.
The solution was dispersed to the nano-scale using a high pressure homogenizer, and the average particle size was controlled to be about 80 nm.
Microcapsule preparation:
Auxiliary components are mixed according to the proportion (for example, 10% of vitamin C, 15% of blueberry powder, 20% of D-mannitol, 5% of astaxanthin, 3% of vitamin E, 0.05% of selenium, 0.5% of glutathione and 1% of lactoferrin).
Gelatin is selected as a wall material, and is mixed with the mixed solution and then is wrapped in the wall material by a spray drying method to form the microcapsule.
Controlled release and targeted modification:
Ethylcellulose is added as a controlled release material during the microcapsule preparation process, so that the microcapsule slowly releases the active ingredient at a specific time (e.g., 2 hours after meal).
The addition of targeting molecules (such as eye tissue specific antibodies) through surface modification ensures that the microcapsules can accurately reach eye tissues.
Example 2:
The raw materials were prepared and nanocrystallised (as in example 1, but with attention paid to the solubility of lutein esters and/or zeaxanthin in the oral liquid).
Solvent selection and proportioning:
Selecting Mel as solvent, and adding adjuvants (such as vitamin C, fructus Myrtilli extract, D-mannitol, vitamin E, selenium compound, glutathione and water soluble forms of lactoferrin) at a certain proportion.
Dispersion of nanoscale lutein esters:
And dispersing the nano lutein ester in a solvent by using an ultrasonic disperser to ensure the uniformity and stability of the solution.
PH adjustment and sterilization:
The pH of the solution is adjusted to a suitable range (e.g., 6.5-7.5) and sterilized.
Packaging and quality inspection:
and (3) filling the oral liquid into a sterile container, and performing quality inspection to ensure that the product is sterile, non-irritating and stable.
Example 3:
Raw material preparation and purification:
Lutein esters from natural plants such as marigold, or zeaxanthin from corn, or both. Solvent extraction is used as a primary purification method to remove most of impurities. Subsequently, further purification by High Performance Liquid Chromatography (HPLC) techniques ensures that the purity of lutein esters and/or zeaxanthin is not less than 98%.
Nanocrystallization:
The purified lutein ester and/or zeaxanthin are dissolved in a proper amount of solvent, and surfactant is added to improve the dispersibility. The solution is subjected to nanocrystallization treatment by using a high-pressure homogenizer or an ultrasonic disperser, so that the average particle size of lutein ester and/or zeaxanthin is reduced to below 100 nanometers, and good bioavailability and stability are ensured.
Auxiliary component preparation:
Other auxiliary ingredients including vitamin C (in powder form, content adjusted according to the formulation), blueberry powder (content adjusted according to the formulation), D-mannitol (as sweetener and filler), astaxanthin (in powder form, content adjusted according to the formulation), vitamin E (in oil or powder form, selected according to solubility), selenium (in sodium selenate or selenium yeast form), glutathione (in powder form) and lactoferrin (in powder form) were prepared. Ensure that all ingredients meet food safety standards.
Mixing and drying:
uniformly mixing the nano lutein ester and/or zeaxanthin solution with the auxiliary components according to a preset proportion. Selecting proper wall materials (such as maltodextrin, sodium alginate and the like), mixing the mixed solution with the wall materials, and drying by spray drying or freeze drying technology. In spray drying, parameters such as spray rate, drying temperature, air flow speed and the like are required to be adjusted so as to obtain ideal particle size and dispersibility. In the freeze drying process, the mixed solution is frozen into a solid state, and then water is sublimated under vacuum condition to obtain dry powder.
Crushing and screening:
The dried powder may contain larger agglomerates that are crushed by a crusher. And then sieving by using a vibrating screen or an air flow screen to remove particles which do not meet the particle size requirement, so as to ensure the uniformity and consistency of the powder.
Packaging and storing:
And placing the sieved powder into a sealed container to avoid direct contact with air, moisture and light. Stored in a cool, dry, light-tight environment to ensure product stability and shelf life.
Quality control and detection:
In the whole preparation process, strict quality control and detection are required. The method comprises the steps of raw material purity detection, particle size detection after nanocrystallization treatment, mixing uniformity detection, moisture content detection after drying, microorganism detection and stability test of a final product and the like. Ensuring that the product meets relevant standards and regulations.

Claims (10)

1. An eye-protecting composition of lutein ester and/or zeaxanthin is characterized by comprising lutein ester and/or zeaxanthin, vitamin C, blueberry powder, D-mannitol, astaxanthin, vitamin E, selenium, glutathione and lactoferrin.
2. The eye-protecting composition of lutein and/or zeaxanthin as defined in claim 1, wherein the purity of lutein and/or zeaxanthin is not less than 98%.
3. The eye-protecting composition of lutein ester and/or zeaxanthin according to claim 1, wherein the content of vitamin C is 5% -15%, the content of blueberry powder is 5% -20%, the content of D-mannitol is 10% -30%, the content of astaxanthin is 5% -15%, the content of vitamin E is 1% -5%, the content of selenium is 0.01% -0.1%, the content of glutathione is 0.1% -1%, and the content of lactoferrin is 0.5% -2%.
4. The eye-care composition of lutein and/or zeaxanthin as defined in claim 1, wherein the average particle size of lutein and/or zeaxanthin is less than 100nm.
5. Use of the eye-care composition according to any one of claims 1-4 for protecting eye health, characterized in that: including oral liquid and powder.
6. The method for producing an eye-care composition according to any one of claims 1 to 4, comprising the steps of:
S1, extracting lutein ester and/or zeaxanthin from natural plants, performing primary purification by a first preset method, and then improving the purity of lutein ester and/or zeaxanthin to not lower than 98% by a second preset method;
S2, mixing the purified lutein ester and/or zeaxanthin with a proper amount of surfactant to form a uniform solution, dispersing the lutein ester and/or zeaxanthin solution to a nano level by using preset equipment, controlling the average particle diameter below 100 nanometers, and preparing other auxiliary components;
s3, uniformly mixing the nano lutein ester and/or zeaxanthin solution with other auxiliary components such as vitamin C, blueberry powder, D-mannitol, astaxanthin, vitamin E, selenium, glutathione and lactoferrin according to a predetermined proportion, selecting a wall material, mixing the wall material with the mixed solution, and coating the wall material in a preset drying manner to form microcapsules or powder;
S4, adding a controlled release material in the preparation process of the microcapsule to enable the microcapsule to slowly release active ingredients under preset time or conditions, and enabling the microcapsule to accurately reach eye tissues through surface modification or addition of targeting molecules;
s5, customizing an oral liquid according to a dosage scheme and a dosage form, wherein the oral liquid takes honey as a carrier.
7. The method according to claim 6, wherein in S1, the first predetermined method comprises solvent extraction, column chromatography or crystallization, and the second predetermined method comprises high performance liquid chromatography HPLC or supercritical fluid extraction SFE.
8. The method of producing an eye-care composition according to claim 6, wherein the auxiliary component comprises vitamin C, blueberry powder, D-mannitol, astaxanthin, vitamin E, selenium, glutathione and lactoferrin, wherein the vitamin E is in the form of oil or powder, and the selenium is in the form of inorganic salts or organic compounds.
9. The method of producing an eye-shielding composition according to claim 6, wherein the pre-setting device comprises a high-pressure homogenizer or an ultrasonic disperser.
10. The method of claim 6, wherein the predetermined drying means comprises spray drying, freeze drying or agglomeration.
CN202411685830.2A 2024-11-23 2024-11-23 Lutein ester and/or zeaxanthin eye protection composition and preparation method and application thereof Pending CN119257247A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202411685830.2A CN119257247A (en) 2024-11-23 2024-11-23 Lutein ester and/or zeaxanthin eye protection composition and preparation method and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202411685830.2A CN119257247A (en) 2024-11-23 2024-11-23 Lutein ester and/or zeaxanthin eye protection composition and preparation method and application thereof

Publications (1)

Publication Number Publication Date
CN119257247A true CN119257247A (en) 2025-01-07

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