CN119214953A - Anti-photodamage essence with added NAD+ composition and preparation process thereof - Google Patents
Anti-photodamage essence with added NAD+ composition and preparation process thereof Download PDFInfo
- Publication number
- CN119214953A CN119214953A CN202411729850.5A CN202411729850A CN119214953A CN 119214953 A CN119214953 A CN 119214953A CN 202411729850 A CN202411729850 A CN 202411729850A CN 119214953 A CN119214953 A CN 119214953A
- Authority
- CN
- China
- Prior art keywords
- parts
- nad
- essence
- composition
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 71
- BAWFJGJZGIEFAR-NNYOXOHSSA-O NAD(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-O 0.000 title claims abstract description 61
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims abstract description 36
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims abstract description 23
- 229920002498 Beta-glucan Polymers 0.000 claims abstract description 23
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 23
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims abstract description 23
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims abstract description 23
- 229920000058 polyacrylate Polymers 0.000 claims abstract description 23
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 23
- 239000011734 sodium Substances 0.000 claims abstract description 23
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 21
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 21
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000000787 lecithin Substances 0.000 claims abstract description 21
- 229940067606 lecithin Drugs 0.000 claims abstract description 21
- 235000010445 lecithin Nutrition 0.000 claims abstract description 21
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 21
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 21
- 239000002562 thickening agent Substances 0.000 claims abstract description 21
- 229940061605 tetrasodium glutamate diacetate Drugs 0.000 claims abstract description 20
- UZVUJVFQFNHRSY-OUTKXMMCSA-J tetrasodium;(2s)-2-[bis(carboxylatomethyl)amino]pentanedioate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CC[C@@H](C([O-])=O)N(CC([O-])=O)CC([O-])=O UZVUJVFQFNHRSY-OUTKXMMCSA-J 0.000 claims abstract description 20
- 230000008832 photodamage Effects 0.000 claims abstract description 17
- 229920006037 cross link polymer Polymers 0.000 claims abstract description 7
- 239000011259 mixed solution Substances 0.000 claims description 50
- 238000003756 stirring Methods 0.000 claims description 40
- 238000002156 mixing Methods 0.000 claims description 32
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 27
- 241000226555 Leontopodium Species 0.000 claims description 25
- 238000006243 chemical reaction Methods 0.000 claims description 24
- 230000001804 emulsifying effect Effects 0.000 claims description 20
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 19
- 239000000284 extract Substances 0.000 claims description 19
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 19
- -1 polyethylene Polymers 0.000 claims description 18
- 239000004698 Polyethylene Substances 0.000 claims description 17
- 229920000573 polyethylene Polymers 0.000 claims description 17
- 238000009775 high-speed stirring Methods 0.000 claims description 16
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 claims description 11
- 229950006238 nadide Drugs 0.000 claims description 11
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 10
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 206010020649 Hyperkeratosis Diseases 0.000 claims description 9
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims description 9
- FZAQROFXYZPAKI-UHFFFAOYSA-N anthracene-2-sulfonyl chloride Chemical compound C1=CC=CC2=CC3=CC(S(=O)(=O)Cl)=CC=C3C=C21 FZAQROFXYZPAKI-UHFFFAOYSA-N 0.000 claims description 9
- 238000000855 fermentation Methods 0.000 claims description 9
- 230000004151 fermentation Effects 0.000 claims description 9
- 239000000706 filtrate Substances 0.000 claims description 9
- 239000006166 lysate Substances 0.000 claims description 9
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 9
- 239000004299 sodium benzoate Substances 0.000 claims description 9
- 235000010234 sodium benzoate Nutrition 0.000 claims description 9
- 239000001509 sodium citrate Substances 0.000 claims description 9
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 9
- 229960004249 sodium acetate Drugs 0.000 claims description 8
- 238000003860 storage Methods 0.000 claims description 8
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 14
- 230000008439 repair process Effects 0.000 abstract description 13
- 230000003712 anti-aging effect Effects 0.000 abstract description 8
- 239000002202 Polyethylene glycol Substances 0.000 abstract description 4
- 230000004069 differentiation Effects 0.000 abstract description 4
- 229920001223 polyethylene glycol Polymers 0.000 abstract description 4
- 230000008929 regeneration Effects 0.000 abstract description 4
- 238000011069 regeneration method Methods 0.000 abstract description 4
- 230000003064 anti-oxidating effect Effects 0.000 abstract description 3
- 230000009759 skin aging Effects 0.000 abstract description 3
- 230000003471 anti-radiation Effects 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 26
- 210000004027 cell Anatomy 0.000 description 13
- 230000003647 oxidation Effects 0.000 description 8
- 238000007254 oxidation reaction Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 7
- 230000032683 aging Effects 0.000 description 6
- 239000006071 cream Substances 0.000 description 6
- 150000003254 radicals Chemical class 0.000 description 5
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- 241000226556 Leontopodium alpinum Species 0.000 description 3
- 230000003833 cell viability Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- DLTWOYCDRWJVIM-JEDNCBNOSA-M sodium;(2s)-2-[bis(carboxymethyl)amino]-5-hydroxy-5-oxopentanoate Chemical compound [Na+].OC(=O)CC[C@@H](C([O-])=O)N(CC(O)=O)CC(O)=O DLTWOYCDRWJVIM-JEDNCBNOSA-M 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000007969 cellular immunity Effects 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 238000001784 detoxification Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 230000007365 immunoregulation Effects 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 230000035790 physiological processes and functions Effects 0.000 description 2
- 239000000419 plant extract Substances 0.000 description 2
- JUJBNYBVVQSIOU-UHFFFAOYSA-M sodium;4-[2-(4-iodophenyl)-3-(4-nitrophenyl)tetrazol-2-ium-5-yl]benzene-1,3-disulfonate Chemical compound [Na+].C1=CC([N+](=O)[O-])=CC=C1N1[N+](C=2C=CC(I)=CC=2)=NC(C=2C(=CC(=CC=2)S([O-])(=O)=O)S([O-])(=O)=O)=N1 JUJBNYBVVQSIOU-UHFFFAOYSA-M 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 230000005778 DNA damage Effects 0.000 description 1
- 231100000277 DNA damage Toxicity 0.000 description 1
- 230000033616 DNA repair Effects 0.000 description 1
- 230000006820 DNA synthesis Effects 0.000 description 1
- 206010012438 Dermatitis atopic Diseases 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 208000001145 Metabolic Syndrome Diseases 0.000 description 1
- 206010051246 Photodermatosis Diseases 0.000 description 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 108091092356 cellular DNA Proteins 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000006567 cellular energy metabolism Effects 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 208000010247 contact dermatitis Diseases 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000009982 effect on human Effects 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 210000005175 epidermal keratinocyte Anatomy 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004898 mitochondrial function Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000008845 photoaging Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000035806 respiratory chain Effects 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 230000008054 signal transmission Effects 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 230000036558 skin tension Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Biophysics (AREA)
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Cosmetics (AREA)
Abstract
The application provides an anti light damage essence solution added with NAD+composition and its preparation process. The components of the essence solution by weight include 20 ‑ 30 NAD+compositions, 1 ‑ 4 butanediol, 8 0.1 ‑ 0.5 palmitoyl tripeptide, 1 ‑ 4 hexanediol, 8 polyethylene glycol, 0.1 ‑ 1 p-hydroxyacetophenone, 1 ‑ 3 lecithin emulsion thickener, 6 0.5 ‑ 2.5 polyacrylate crosslinked polymer, 0.01 ‑ 1 sodium hyaluronate, 0.1 ‑ 0.8 daily essence, 2 ‑ 5 portions of carboxymethyl β ‑ glucan sodium and 0.1 ‑ 1 portion of tetrasodium glutamate diacetate. The preparation process of this application is simple. The prepared essence has the effects of anti free radicals, anti-oxidation, anti radiation and anti light damage. At the same time, the added NAD+composition can better play the role of anti-aging and firming skin, and can be effectively absorbed by the skin, Promote cell regeneration and differentiation ability, help enhance skin resilience, repair skin, improve skin quality, delay skin aging, and achieve an integrated self repair and protection system inside and outside the cell.
Description
Technical Field
The application relates to the technical field of cosmetics, in particular to a photodamage-resistant essence added with an NAD+ composition and a preparation process thereof.
Background
Light pollution is a phenomenon that excessive or inappropriate light radiation generated in modern society has an adverse effect on human life and production environment. The damage of the front ultraviolet rays and the blue light to the skin of a human body also causes more and more attention, the ultraviolet rays and the blue light can cause skin cells to generate excessive active oxygen, the oxidation degree in the body exceeds the removal speed of oxides, the oxidation and antioxidation systems are unbalanced, and the excessive active oxygen presses the cells, so that DNA damage, lipid peroxidation, collagen structure damage and mitochondrial function damage can be caused. These lesions may eventually cause skin problems or skin diseases, such as photoaging, contact dermatitis, atopic dermatitis, skin cancer, seborrheic dermatitis, etc
The active ingredients from plant sources are used in the market and are common in photodamage-resistant cosmetics, but the photodamage-resistant effect is general, and the photodamage-resistant cosmetics have no skin anti-aging and tightening effects, so that the photodamage-resistant essence added with the NAD+ composition is developed.
Disclosure of Invention
The application provides an anti-photodamage essence added with an NAD+ composition and a preparation process thereof, which are used for solving the problem of poor anti-photodamage effect of the existing cosmetics and realizing the effects of free radical resistance, oxidation resistance, radiation resistance and photodamage resistance.
The application provides a photodamage resistant essence added with an NAD+ composition, which comprises, by weight, 20-30 parts of the NAD+ composition, 1-4 parts of butanediol, 0.1-0.5 part of palmitoyl tripeptide-8, 1-4 parts of 1, 2-hexanediol, 0.1-1 part of polyethylene glycol-8 4-8 parts of p-hydroxyacetophenone, 1-3 parts of lecithin emulsifying thickener, 0.5-2.5 parts of polyacrylate crosslinked polymer, 0.01-1 part of sodium hyaluronate, 0.1-0.8 part of daily essence, 2-5 parts of carboxymethyl beta-glucan sodium and 0.1-1 part of tetrasodium glutamate diacetate.
Preferably, the essence comprises, by weight, 25 parts of an NAD+ composition, 3 parts of butanediol, 0.3 part of palmitoyl tripeptide-8, 3 parts of 1, 2-hexanediol, 86 parts of polyethylene glycol, 0.6 part of p-hydroxyacetophenone, 2 parts of lecithin emulsifying thickener, 62 parts of polyacrylate crosslinked polymer, 0.4 part of sodium hyaluronate, 0.5 part of daily essence, 4 parts of sodium carboxymethyl beta-glucan and 0.6 part of tetrasodium glutamate diacetate.
Preferably, the NAD+ composition comprises 40-50 parts by weight of dipropylene glycol, 0.1-1 part by weight of nicotinamide, 0.001-0.01 part by weight of nicotinamide adenine dinucleotide, 0.05-0.1 part by weight of beta-nicotinamide mononucleotide, 0.1-0.5 part by weight of alpine leontopodium flower/leaf extract, 0.1-0.5 part by weight of alpine leontopodium callus extract, 0.1-0.5 part by weight of alpine leontopodium yeast fermentation lysate filtrate, 0.1-0.5 part by weight of citric acid, 0.05-0.1 part by weight of sodium citrate, 0.1-0.3 part by weight of sodium benzoate and 40-60 parts by weight of water.
Preferably, a preparation process of the photodamage resistant essence added with the NAD+ composition comprises the following steps:
A. mixing butanediol, palmitoyl tripeptide-8, 1, 2-hexanediol, polyethylene glycol-8, p-hydroxyacetophenone and lecithin emulsifying thickener, and adding the mixture into a stirring tank for low-speed stirring to obtain a first mixed solution;
B. Mixing polyacrylate crosslinked polymer-6, sodium hyaluronate, daily essence, carboxymethyl beta-glucan sodium and tetra sodium glutamate diacetate, and then adding into a stirring tank for high-speed stirring to obtain a second mixed solution;
C. mixing the first mixed solution and the second mixed solution, and then adding the mixed solution into a reaction tank to perform ultrasonic reaction to obtain a third mixed solution;
D. and finally, adding the NAD+ composition into the third mixed solution, and stirring and uniformly mixing at normal temperature to obtain the photodamage-resistant essence.
Preferably, in the step A, the low-speed stirring speed is 80-180 rpm, and the time is 10-18 min.
Preferably, in the step B, the high-speed stirring speed is 3000-5000 rpm, and the time is 20-40 min.
Preferably, in the step C, the frequency of the ultrasonic reaction is 40-80kHz, the temperature is 10-20 ℃ and the time is 2-6 min.
Preferably, the storage temperature in step D is maintained at 20-25 ℃.
The invention has the beneficial effects that the preparation process is simple, the prepared essence has the functions of resisting free radicals, oxidation, radiation and photodamage, the added NAD+ composition can better play roles of resisting skin aging and tightening, can be effectively absorbed by the skin, promote the regeneration and differentiation capacity of cells, help to promote the resilience of the skin, repair the skin, improve the skin quality, delay the aging of the skin and achieve an integrated self-repairing-protecting system inside and outside the cell, wherein the added palmitoyl tripeptide-8 has various biological activities such as antibiosis, oxidation resistance, immunoregulation, cholesterol reduction and the like, can effectively filter the spectrum within the range of 280nm-500nm, the added polyacrylate crosslinked polymer-6 can form good shielding property, achieve good filtering effect, and the added sodium carboxymethyl beta-glucan and tetrasodium glutamate diacetate have various physiological functions of scavenging free radicals, detoxification, maintaining the biosynthesis of DNA, normal growth of the cells, cell immunity and the like.
The foregoing description is only an overview of the technical solutions of the embodiments of the present application, and may be implemented according to the content of the specification, so that the technical means of the embodiments of the present application can be more clearly understood, and the following specific embodiments of the present application are given for clarity and understanding.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for the description of the embodiments will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present application, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a diagram of a cell scratch test according to the present invention.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present application more apparent, the technical solutions of the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present application, and it is apparent that the described embodiments are some embodiments of the present application, but not all embodiments of the present application. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs, the terms used in the description of this application are for the purpose of describing particular embodiments only and are not intended to be limiting of the application, and the terms "comprising" and "having" and any variations thereof in the description of this application and the claims and drawings are intended to cover non-exclusive inclusions.
Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment may be included in at least one embodiment of the application. The appearances of the phrase "an embodiment" in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. Those of skill in the art will explicitly and implicitly appreciate that the embodiments described herein may be combined with other embodiments.
In order to make the person skilled in the art better understand the solution of the present application, the technical solution of the embodiment of the present application will be clearly and completely described below with reference to the accompanying drawings.
The application provides a photodamage resistant essence added with an NAD+ composition, which comprises, by weight, 20-30 parts of the NAD+ composition, 1-4 parts of butanediol, 0.1-0.5 part of palmitoyl tripeptide-8, 1-4 parts of 1, 2-hexanediol, 0.1-1 part of polyethylene glycol-8 4-8 parts of p-hydroxyacetophenone, 1-3 parts of lecithin emulsifying thickener, 0.5-2.5 parts of polyacrylate crosslinked polymer, 0.01-1 part of sodium hyaluronate, 0.1-0.8 part of daily essence, 2-5 parts of carboxymethyl beta-glucan sodium and 0.1-1 part of tetrasodium glutamate diacetate.
Embodiment one;
The essence comprises, by weight, 20 parts of an NAD+ composition, 1 part of butanediol, 0.1 part of palmitoyl tripeptide-8, 1, 2-hexanediol, 1 part of polyethylene glycol-8 4 parts of p-hydroxyacetophenone, 0.1 part of lecithin emulsifying thickener, 0.5 part of polyacrylate crosslinked polymer-6, 0.01 part of sodium hyaluronate, 0.1 part of daily essence, 2 parts of carboxymethyl beta-glucan sodium and 0.1 part of monosodium glutamate diacetate.
In this example, the NAD+ composition comprises 40 parts dipropylene glycol, 0.1 part nicotinamide, 0.001 part nicotinamide adenine dinucleotide, 0.05 part beta-nicotinamide mononucleotide, 0.1 part alpine leontopodium flower/leaf extract, 0.1 part alpine leontopodium callus extract, 0.1 part alpine leontopodium yeast fermentation lysate filtrate, 0.1 part citric acid, 0.05 part sodium citrate, 0.1 part sodium benzoate, and 58 parts water.
In this embodiment, a preparation process of the anti-photodamage essence added with the NAD+ composition comprises the following steps:
A. mixing butanediol, palmitoyl tripeptide-8, 1, 2-hexanediol, polyethylene glycol-8, p-hydroxyacetophenone and lecithin emulsifying thickener, and adding the mixture into a stirring tank for low-speed stirring to obtain a first mixed solution;
B. Mixing polyacrylate crosslinked polymer-6, sodium hyaluronate, daily essence, carboxymethyl beta-glucan sodium and tetra sodium glutamate diacetate, and then adding into a stirring tank for high-speed stirring to obtain a second mixed solution;
C. mixing the first mixed solution and the second mixed solution, and then adding the mixed solution into a reaction tank to perform ultrasonic reaction to obtain a third mixed solution;
D. And adding the NAD+ composition into the third mixture, and stirring and mixing uniformly at normal temperature to obtain the anti-aging repair face cream.
In this example, in step A, the low-speed stirring rate was 80 rpm and the time was 10 minutes.
In this example, in step B, the high-speed stirring rate was 3000 rpm, and the time was 20 minutes.
In this example, in step C, the frequency of the ultrasonic reaction was 40kHz, the temperature was 10℃and the time was 2 minutes.
In this example, the storage temperature in step D is maintained at 20 ℃.
Embodiment two;
The essence comprises, by weight, 30 parts of an NAD+ composition, 4 parts of butanediol, 0.5 part of palmitoyl tripeptide-8, 4 parts of 1, 2-hexanediol, 88 parts of polyethylene glycol-p-hydroxyacetophenone, 3 parts of lecithin emulsifying thickener, 2.5 parts of polyacrylate crosslinked polymer-6, 1 part of sodium hyaluronate, 0.8 part of daily essence, 5 parts of carboxymethyl beta-glucan sodium and 1 part of tetrasodium glutamate diacetate.
In this example, the NAD+ composition comprises, by weight, 50 parts of dipropylene glycol, 1 part of nicotinamide, 0.01 part of nicotinamide adenine dinucleotide, 0.1 part of beta-nicotinamide mononucleotide, 0.5 part of a leontopodium alpinum flower/leaf extract, 0.5 part of a leontopodium alpinum callus extract, 0.5 part of a leontopodium alpinum fermentation lysate filtrate, 0.5 part of citric acid, 0.1 part of sodium citrate, 0.3 part of sodium benzoate, and 46 parts of water.
In this embodiment, a preparation process of the anti-photodamage essence added with the NAD+ composition comprises the following steps:
A. mixing butanediol, palmitoyl tripeptide-8, 1, 2-hexanediol, polyethylene glycol-8, p-hydroxyacetophenone and lecithin emulsifying thickener, and adding the mixture into a stirring tank for low-speed stirring to obtain a first mixed solution;
B. Mixing polyacrylate crosslinked polymer-6, sodium hyaluronate, daily essence, carboxymethyl beta-glucan sodium and tetra sodium glutamate diacetate, and then adding into a stirring tank for high-speed stirring to obtain a second mixed solution;
C. mixing the first mixed solution and the second mixed solution, and then adding the mixed solution into a reaction tank to perform ultrasonic reaction to obtain a third mixed solution;
D. And adding the NAD+ composition into the third mixture, and stirring and mixing uniformly at normal temperature to obtain the anti-aging repair face cream.
In this example, in step A, the low-speed stirring rate was 180 rpm and the time was 18 minutes.
In this example, in step B, the high-speed stirring rate was 5000 rpm and the time was 40min.
In this example, in step C, the frequency of the ultrasonic reaction was 80kHz, the temperature was 20℃and the time was 6 minutes.
In this example, the storage temperature in step D is maintained at 25 ℃.
Embodiment three;
The essence comprises, by weight, 22 parts of an NAD+ composition, 2 parts of butanediol, 0.2 part of palmitoyl tripeptide-8, 2 parts of 1, 2-hexanediol, 85 parts of polyethylene glycol, 0.2 part of p-hydroxyacetophenone, 2 parts of lecithin emulsifying thickener, 0.8 part of polyacrylate crosslinked polymer-6, 0.04 part of sodium hyaluronate, 0.2 part of daily essence, 3 parts of sodium carboxymethyl beta-glucan and 0.3 part of tetrasodium glutamate diacetate.
In this example, the NAD+ composition comprises 42 parts by weight of dipropylene glycol, 0.2 part by weight of nicotinamide, 0.003 part by weight of nicotinamide adenine dinucleotide, 0.06 part by weight of beta-nicotinamide mononucleotide, 0.2 part by weight of alpine leontopodium flower/leaf extract, 0.2 part by weight of alpine leontopodium callus extract, 0.2 part by weight of alpine leontopodium yeast fermentation lysate filtrate, 0.2 part by weight of citric acid, 0.06 part by weight of sodium citrate, 0.2 part by weight of sodium benzoate, and 56 parts by weight of water.
In this embodiment, a preparation process of the anti-photodamage essence added with the NAD+ composition comprises the following steps:
A. mixing butanediol, palmitoyl tripeptide-8, 1, 2-hexanediol, polyethylene glycol-8, p-hydroxyacetophenone and lecithin emulsifying thickener, and adding the mixture into a stirring tank for low-speed stirring to obtain a first mixed solution;
B. Mixing polyacrylate crosslinked polymer-6, sodium hyaluronate, daily essence, carboxymethyl beta-glucan sodium and tetra sodium glutamate diacetate, and then adding into a stirring tank for high-speed stirring to obtain a second mixed solution;
C. mixing the first mixed solution and the second mixed solution, and then adding the mixed solution into a reaction tank to perform ultrasonic reaction to obtain a third mixed solution;
D. And adding the NAD+ composition into the third mixture, and stirring and mixing uniformly at normal temperature to obtain the anti-aging repair face cream.
In this example, in step A, the low-speed stirring rate was 90 rpm and the time was 11 minutes.
In this example, in step B, the high-speed stirring rate was 3500 rpm and the time was 25 minutes.
In this example, in step C, the frequency of the ultrasonic reaction was 45kHz, the temperature was 12℃and the time was 3 minutes.
In this example, the storage temperature in step D is maintained at 21 ℃.
Fourth embodiment;
The essence comprises, by weight, 28 parts of an NAD+ composition, 3 parts of butanediol, 0.4 part of palmitoyl tripeptide-8, 3 parts of 1, 2-hexanediol, 87 parts of polyethylene glycol-p-hydroxyacetophenone, 0.8 part of lecithin emulsifying thickener, 2 parts of polyacrylate crosslinked polymer-6.4 parts, 0.7 part of sodium hyaluronate, 0.7 part of daily essence, 4 parts of carboxymethyl beta-glucan sodium and 0.8 part of monosodium glutamate diacetate.
In this example, the NAD+ composition comprises 48 parts by weight of dipropylene glycol, 0.9 part by weight of nicotinamide, 0.0091 part by weight of nicotinamide adenine dinucleotide, 0.09 part by weight of beta-nicotinamide mononucleotide, 0.4 part by weight of alpine leontopodium flower/leaf extract, 0.4 part by weight of alpine leontopodium callus extract, 0.4 part by weight of alpine leontopodium yeast fermentation lysate filtrate, 0.4 part by weight of citric acid, 0.09 part by weight of sodium citrate, 0.2 part by weight of sodium benzoate, and 50 parts by weight of water.
In this embodiment, a preparation process of the anti-photodamage essence added with the NAD+ composition comprises the following steps:
A. mixing butanediol, palmitoyl tripeptide-8, 1, 2-hexanediol, polyethylene glycol-8, p-hydroxyacetophenone and lecithin emulsifying thickener, and adding the mixture into a stirring tank for low-speed stirring to obtain a first mixed solution;
B. Mixing polyacrylate crosslinked polymer-6, sodium hyaluronate, daily essence, carboxymethyl beta-glucan sodium and tetra sodium glutamate diacetate, and then adding into a stirring tank for high-speed stirring to obtain a second mixed solution;
C. mixing the first mixed solution and the second mixed solution, and then adding the mixed solution into a reaction tank to perform ultrasonic reaction to obtain a third mixed solution;
D. And adding the NAD+ composition into the third mixture, and stirring and mixing uniformly at normal temperature to obtain the anti-aging repair face cream.
In this example, in step A, the low-speed stirring rate was 170 rpm and the time was 17 minutes.
In this example, in step B, the high speed stirring rate was 4500 rpm for 35min.
In this example, in step C, the frequency of the ultrasonic reaction was 70kHz, the temperature was 18℃and the time was 5 minutes.
In this example, the storage temperature in step D is maintained at 24 ℃.
Fifth embodiment;
The essence comprises, by weight, 20 parts of an NAD+ composition, 4 parts of butanediol, 0.1 part of palmitoyl tripeptide-8, 4 parts of 1, 2-hexanediol, 84 parts of polyethylene glycol, 1 part of p-hydroxyacetophenone, 1 part of lecithin emulsifying thickener, 2.5 parts of polyacrylate crosslinked polymer-6, 0.01 part of sodium hyaluronate, 0.8 part of daily essence, 2 parts of carboxymethyl beta-glucan sodium and 1 part of tetra sodium glutamate diacetate.
In this example, the NAD+ composition comprises, by weight, 43 parts of dipropylene glycol, 03 parts of nicotinamide, 0.003 part of nicotinamide adenine dinucleotide, 0.06 part of beta-nicotinamide mononucleotide, 0.2 part of a high mountain leontopodium flower/leaf extract, 0.3 part of a high mountain leontopodium callus extract, 0.4 part of a high mountain leontopodium yeast fermentation lysate filtrate, 0.2 part of citric acid, 0.07 part of sodium citrate, 0.2 part of sodium benzoate, and 56 parts of water.
In this embodiment, a preparation process of the anti-photodamage essence added with the NAD+ composition comprises the following steps:
A. mixing butanediol, palmitoyl tripeptide-8, 1, 2-hexanediol, polyethylene glycol-8, p-hydroxyacetophenone and lecithin emulsifying thickener, and adding the mixture into a stirring tank for low-speed stirring to obtain a first mixed solution;
B. Mixing polyacrylate crosslinked polymer-6, sodium hyaluronate, daily essence, carboxymethyl beta-glucan sodium and tetra sodium glutamate diacetate, and then adding into a stirring tank for high-speed stirring to obtain a second mixed solution;
C. mixing the first mixed solution and the second mixed solution, and then adding the mixed solution into a reaction tank to perform ultrasonic reaction to obtain a third mixed solution;
D. And adding the NAD+ composition into the third mixture, and stirring and mixing uniformly at normal temperature to obtain the anti-aging repair face cream.
In this example, in step A, the low-speed stirring rate was 180 rpm and the time was 10 minutes.
In this example, in step B, the high-speed stirring rate was 5000 rpm and the time was 20 minutes.
In this example, in step C, the frequency of the ultrasonic reaction was 80kHz, the temperature was 10℃and the time was 2 minutes.
In this example, the storage temperature in step D is maintained at 22 ℃.
Example six;
The essence comprises, by weight, 25 parts of an NAD+ composition, 3 parts of butanediol, 0.3 part of palmitoyl tripeptide-8, 3 parts of1, 2-hexanediol, 86 parts of polyethylene glycol-p-hydroxyacetophenone, 0.6 part of lecithin emulsifying thickener, 2 parts of polyacrylate crosslinked polymer-6 2 parts, 0.4 part of sodium hyaluronate, 0.5 part of daily essence, 4 parts of carboxymethyl beta-glucan sodium and 0.6 part of monosodium glutamate diacetate.
In this example, the NAD+ composition comprises 45 parts dipropylene glycol, 0.5 part nicotinamide, 0.005 part nicotinamide adenine dinucleotide, 0.07 part beta-nicotinamide mononucleotide, 0.3 part alpine leontopodium flower/leaf extract, 0.3 part alpine leontopodium callus extract, 0.3 part alpine leontopodium yeast fermentation lysate filtrate, 0.3 part citric acid, 0.06 part sodium citrate, 0.2 part sodium benzoate, and 52 parts water.
In this embodiment, a preparation process of the anti-photodamage essence added with the NAD+ composition comprises the following steps:
A. mixing butanediol, palmitoyl tripeptide-8, 1, 2-hexanediol, polyethylene glycol-8, p-hydroxyacetophenone and lecithin emulsifying thickener, and adding the mixture into a stirring tank for low-speed stirring to obtain a first mixed solution;
B. Mixing polyacrylate crosslinked polymer-6, sodium hyaluronate, daily essence, carboxymethyl beta-glucan sodium and tetra sodium glutamate diacetate, and then adding into a stirring tank for high-speed stirring to obtain a second mixed solution;
C. mixing the first mixed solution and the second mixed solution, and then adding the mixed solution into a reaction tank to perform ultrasonic reaction to obtain a third mixed solution;
D. And adding the NAD+ composition into the third mixture, and stirring and mixing uniformly at normal temperature to obtain the anti-aging repair face cream.
In this example, in step A, the low-speed stirring rate was 130 rpm and the time was 14min.
In this example, in step B, the high-speed stirring rate was 4000 rpm and the time was 30 minutes.
In this example, in step C, the frequency of the ultrasonic reaction was 60kHz, the temperature was 15℃and the time was 4 minutes.
In this example, the storage temperature in step D is maintained at 24 ℃.
Test example:
Taking human epidermal keratinocyte HaCaT in logarithmic growth phase, inoculating into 96-well plate at density of 2×10 4/mL, inoculating 100 μL per well, culturing in DMEM high sugar culture solution, adding 10% fetal bovine serum, culturing with carbon dioxide incubator 37 deg.C and 5% CO 2 for 24 hr, irradiating with ultraviolet lamp and LED blue light lamp, and detecting relative proliferation rate of cells by WST-1 method.
In addition, a group of essence is prepared, wherein the essence comprises, by weight, 25 parts of NAD+ composition, 3 parts of butanediol, 0.3 part of palmitoyl tripeptide-8, 3 parts of 1, 2-hexanediol, 0.6 part of polyethylene glycol-8 6 part of p-hydroxyacetophenone, 2 parts of lecithin emulsifying thickener, 62 parts of polyacrylate crosslinked polymer, 0.4 part of sodium hyaluronate, 0.5 part of daily essence, 4 parts of sodium carboxymethyl beta-glucan and 0.6 part of tetrasodium glutamate diacetate, the NAD+ composition comprises, by weight, 45 parts of dipropylene glycol, 0.5 part of nicotinamide, 0.005 part of nicotinamide adenine dinucleotide, 0.07 part of beta-nicotinamide mononucleotide, 0.3 part of citric acid, 0.06 part of sodium citrate, 0.2 part of sodium benzoate and 52 parts of water, the same test conditions are adopted, the relative cell viability (see Table 1) is detected by a WST-1 method, the OD value is measured at a wavelength of 450nm, the cell viability= (OD + light adding value) is compared with the cell viability value and the cell repair effect is verified by using a scratch repair experiment sample.
Nad+ composition:
Essence examples:
Table 1 the data are given in the following table:
From the experimental data in the table, the essence of the invention can effectively improve the relative proliferation rate of cells, further can better play roles of resisting aging and tightening skin, can be effectively absorbed by the skin, promote the regeneration and differentiation capacity of the cells, help to improve the resilience force of the skin, repair the skin, improve the skin quality and delay the aging of the skin, and does not add essence of the flower/leaf extract of the alpine leontopodium herb, the callus extract of the alpine leontopodium herb and the fermentation lysate filtrate of the alpine leontopodium herb, so that the relative proliferation rate of the cells cannot be effectively improved, and the use effect of the essence is further affected.
In addition, the cell scratch experiment is carried out in the invention, and as can be seen from fig. 1, after 18 hours, the repairing effect of the 1% essence example six is better than that of the 1% essence experiment example and the 1% essence group without the NAD composition, which shows that the effect of compounding NAD+ and the plant extract is better than that of using NAD+ singly and also better than that of the essence without the NAD+ composition. The compounding of NAD+ and plant extracts has synergistic restoration effect.
NAD+ is a key component in maintaining cellular metabolism and function and is found in various tissues such as skin. And indicates that aging causes the reduction of NAD+ level, which possibly affects the restoration capacity of skin, the dipropylene glycol added by the invention has good water, oil and hydrocarbon co-dissolution capacity, light smell, little skin irritation and low toxicity; the added nicotinamide plays a role in delivering hydrogen in a biological oxidation respiratory chain, can promote a biological oxidation process and tissue metabolism, plays an important role in maintaining the integrity of normal tissues, is a coenzyme for delivering hydrogen ions, participates in various physiological activities such as cellular material metabolism, energy synthesis and cellular DNA repair, is one of key precursors of the nicotinamide adenine dinucleotide, participates in cellular energy metabolism and signal transmission, shows potential application value in the aspects of resisting aging, improving metabolic syndrome and the like, can gently and deeply clean skin, remove grease and pore internal pollutants of epidermis, simultaneously relieve skin tension state, is soft and does not tighten, is natural in whitening components, can help to part in metabolism impurities, prevent pigmentation, is smooth and fine after use, is white and glossy, is effective in soothing and skin, and discharges harmful substances in skin, and the added alpine leontopodium herb extract has good effects of nourishing skin, and moisturizing skin, and protecting skin.
In conclusion, the preparation process is simple, the prepared essence has the effects of resisting free radicals, resisting oxidation, resisting radiation and resisting photodamage, the NAD+ composition added can better play roles of resisting aging and tightening skin, can be effectively absorbed by the skin, promotes the regeneration and differentiation capacity of cells, helps to promote the resilience of the skin, repairs the skin, improves the skin quality, delays skin aging, and achieves an integrated self-repairing-protecting system inside and outside the cell, wherein the palmitoyl tripeptide-8 added has various biological activities such as antibiosis, antioxidation, immunoregulation, cholesterol reduction and the like, can effectively filter a spectrum within a range of 280nm-500nm, the polyacrylate crosslinked polymer-6 added can form good shielding performance, achieve a good filtering effect, and the added sodium carboxymethyl beta-glucan and the tetrasodium glutamate diacetate have various physiological functions such as free radical removal, detoxification, DNA biosynthesis maintenance, normal growth of cells, cell immunity and the like.
While the application has been described in detail with reference to the foregoing embodiments, it will be understood by those skilled in the art that the foregoing embodiments may be modified or equivalents may be substituted for some of the features thereof, and that the modifications or substitutions do not depart from the spirit of the embodiments.
Claims (8)
1. The anti-photodamage essence added with the NAD+ composition is characterized by comprising, by weight, 20-30 parts of the NAD+ composition, 1-4 parts of butanediol, 0.1-0.5 part of palmitoyl tripeptide-8, 1-4 parts of 1, 2-hexanediol, 1-3 parts of polyethylene glycol-8 4-8 parts of p-hydroxyacetophenone, 1-3 parts of lecithin emulsifying thickener, 0.5-2.5 parts of polyacrylate crosslinked polymer, 0.01-1 part of sodium hyaluronate, 0.1-0.8 part of daily essence, 2-5 parts of carboxymethyl beta-glucan sodium and 0.1-1 part of tetrasodium glutamate diacetate.
2. The anti-photodamage essence added with the NAD+ composition according to claim 1, wherein the essence comprises, by weight, 25 parts of the NAD+ composition, 3 parts of butanediol, 0.3 part of palmitoyl tripeptide-8, 3 parts of 1, 2-hexanediol, 3 parts of polyethylene glycol-8 6 parts of p-hydroxyacetophenone, 2 parts of lecithin emulsifying thickener, 62 parts of polyacrylate crosslinked polymer, 0.4 part of sodium hyaluronate, 0.5 part of daily essence, 4 parts of sodium carboxymethyl beta-glucan and 0.6 part of tetra sodium glutamate diacetate.
3. The NAD+ composition-added photodamage-resistant essence according to claim 1, wherein the NAD+ composition comprises, by weight, 40-50 parts of dipropylene glycol, 0.1-1 part of nicotinamide, 0.001-0.01 part of nicotinamide adenine dinucleotide, 0.05-0.1 part of beta-nicotinamide mononucleotide, 0.1-0.5 part of alpine leontopodium flower/leaf extract, 0.1-0.5 part of alpine leontopodium callus extract, 0.1-0.5 part of alpine leontopodium yeast fermentation lysate filtrate, 0.1-0.5 part of citric acid, 0.05-0.1 part of sodium citrate, 0.1-0.3 part of sodium benzoate, and 40-60 parts of water.
4. The preparation process for realizing the photodamage-resistant essence added with the NAD+ composition as claimed in claim 1 is characterized by comprising the following steps:
A. mixing butanediol, palmitoyl tripeptide-8, 1, 2-hexanediol, polyethylene glycol-8, p-hydroxyacetophenone and lecithin emulsifying thickener, and adding the mixture into a stirring tank for low-speed stirring to obtain a first mixed solution;
B. Mixing polyacrylate crosslinked polymer-6, sodium hyaluronate, daily essence, carboxymethyl beta-glucan sodium and tetra sodium glutamate diacetate, and then adding into a stirring tank for high-speed stirring to obtain a second mixed solution;
C. mixing the first mixed solution and the second mixed solution, and then adding the mixed solution into a reaction tank to perform ultrasonic reaction to obtain a third mixed solution;
D. and finally, adding the NAD+ composition into the third mixed solution, and stirring and uniformly mixing at normal temperature to obtain the photodamage-resistant essence.
5. The process for preparing the anti-photodamage essence with the NAD+ composition according to claim 4, the method is characterized in that in the step A, the low-speed stirring speed is 80-180 rpm, and the time is 10-18 min.
6. The process for preparing the anti-photodamage essence added with the NAD+ composition according to claim 4, wherein in the step B, the high-speed stirring speed is 3000-5000 rpm, and the time is 20-40 min.
7. The process of claim 4, wherein in step C, the ultrasonic reaction is carried out at a frequency of 40-80kHz, a temperature of 10-20 ℃ and a time of 2-6 min.
8. The process for preparing the anti-photodamage essence with the NAD+ composition according to claim 4, characterized in that the storage temperature in step D is maintained at 20-25 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202411729850.5A CN119214953A (en) | 2024-11-29 | 2024-11-29 | Anti-photodamage essence with added NAD+ composition and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202411729850.5A CN119214953A (en) | 2024-11-29 | 2024-11-29 | Anti-photodamage essence with added NAD+ composition and preparation process thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN119214953A true CN119214953A (en) | 2024-12-31 |
Family
ID=94047788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202411729850.5A Pending CN119214953A (en) | 2024-11-29 | 2024-11-29 | Anti-photodamage essence with added NAD+ composition and preparation process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN119214953A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150250709A1 (en) * | 2014-03-10 | 2015-09-10 | Mary Kay Inc. | Skin Lightening Compositions |
| CN111184677A (en) * | 2020-03-03 | 2020-05-22 | 深圳市玉莱漫科技发展有限公司 | NMN-containing anti-aging essence and preparation method thereof |
| CN114073658A (en) * | 2021-11-23 | 2022-02-22 | 湖北省麦诗特生物科技有限公司 | Essence composition containing liposome capable of resisting photoaging damage and preparation method thereof |
| CN115813795A (en) * | 2022-12-30 | 2023-03-21 | 泉后(广州)生物科技研究院有限公司 | Anti-wrinkle composition and application thereof |
| CN117064789A (en) * | 2023-09-25 | 2023-11-17 | 广东柏俐臣生物科技有限公司 | Anti-aging composition and preparation method thereof |
-
2024
- 2024-11-29 CN CN202411729850.5A patent/CN119214953A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150250709A1 (en) * | 2014-03-10 | 2015-09-10 | Mary Kay Inc. | Skin Lightening Compositions |
| CN111184677A (en) * | 2020-03-03 | 2020-05-22 | 深圳市玉莱漫科技发展有限公司 | NMN-containing anti-aging essence and preparation method thereof |
| CN114073658A (en) * | 2021-11-23 | 2022-02-22 | 湖北省麦诗特生物科技有限公司 | Essence composition containing liposome capable of resisting photoaging damage and preparation method thereof |
| CN115813795A (en) * | 2022-12-30 | 2023-03-21 | 泉后(广州)生物科技研究院有限公司 | Anti-wrinkle composition and application thereof |
| CN117064789A (en) * | 2023-09-25 | 2023-11-17 | 广东柏俐臣生物科技有限公司 | Anti-aging composition and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110772468A (en) | Oat and tremella fermentation product filtrate and preparation method thereof | |
| CN112043619B (en) | Peptide composition with repairing effect and preparation method and application thereof | |
| CN116650347B (en) | Anti-wrinkle essential oil facial mask containing pink microalgae and spilanthol and preparation method thereof | |
| CN117752551A (en) | Whitening spot-removing and permeation-assisting composition, cream and preparation method of composition | |
| CN119925247A (en) | Asparagus fermentation extract, preparation method and application thereof, and cosmetic composition and cosmetic for relieving and resisting aging | |
| CN111544324A (en) | Composition and cosmetic for improving skin elasticity | |
| CN108852969B (en) | Anti-wrinkle anti-aging whitening mask and preparation method thereof | |
| CN111603404B (en) | Skin care essence containing cell extracting solution and preparation method thereof | |
| CN119214953A (en) | Anti-photodamage essence with added NAD+ composition and preparation process thereof | |
| CN109700750A (en) | A kind of anti-ageing face mask and preparation method thereof containing sodium hyaluronate | |
| CN118286096B (en) | A kind of spot-lightening and whitening essence and preparation method thereof | |
| CN116473883A (en) | Anti-aging composition and preparation method and application thereof | |
| CN117653575A (en) | Saussurea involucrata extract and skin care composition containing saussurea involucrata extract | |
| CN113876662B (en) | Skin care composition with anti-aging effect and preparation method and application thereof | |
| CN117281748A (en) | A cosmetic composition containing mushroom extract for promoting skin repair | |
| CN115590931A (en) | Activatable NAD + Expressed composition and application thereof in dispelling effects of alcohol and protecting liver | |
| CN107485587A (en) | A kind of crease-resistant beauty treatment honey of blueberry and preparation method thereof | |
| CN113143791A (en) | Compound injection with whitening and anti-aging effects and preparation method thereof | |
| CN111437220B (en) | Camellia oil fatty acid ester composition and preparation method and application thereof | |
| CN118717595B (en) | A composite plant fermentation product and its preparation method, application and daily chemical product | |
| CN111743798A (en) | A kind of multi-effect anti-aging skin care product and preparation method thereof | |
| CN119257970A (en) | Anti-aging repairing facial cream with NAD+ composition added and preparation process thereof | |
| CN118910187B (en) | A biopolysaccharide that synergistically promotes the expression of ceramide synthase and/or hyaluronic acid synthase and its application | |
| CN115836988B (en) | Cosmetic composition, essence emulsion and preparation method thereof | |
| LU509272B1 (en) | Anti-aging functional peptide composition and preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |