CN119214945A

CN119214945A - A functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in middle-aged and elderly people and a preparation method thereof

Info

Publication number: CN119214945A
Application number: CN202411746701.XA
Authority: CN
Inventors: 方凯雷; 李想
Original assignee: Shanghai Hongfang Network Technology Co ltd
Current assignee: Shanghai Hongfang Network Technology Co ltd
Priority date: 2024-12-02
Filing date: 2024-12-02
Publication date: 2024-12-31

Abstract

The invention relates to an efficacy material body containing composite hydroxyapatite for relieving halitosis of middle-aged and elderly people, and a preparation method thereof, belonging to the technical field of dental oral care. The functional material body has a good effect of relieving bad breath of middle-aged and elderly people and dry mouth, and is prepared from the following raw materials, by weight, 10-15 parts of deionized water, 0.1-0.3 part of a sweetener, 2-3 parts of a surfactant, 3-5 parts of glycerin, 30-35 parts of a humectant, 0.6-1 part of a thickener, 3-5 parts of trehalose, 25-35 parts of composite hydroxyapatite, 0.1-0.2 part of superoxide dismutase and 0.1-0.2 part of glucanase.

Description

Functional material body containing composite hydroxyapatite for relieving dry mouth halitosis of middle-aged and elderly people and preparation method thereof

Technical Field

The invention belongs to the technical field of dental oral care, and relates to a functional material body containing composite hydroxyapatite for relieving halitosis of middle-aged and elderly people and a preparation method thereof.

Background

The middle-aged and elderly people have reduced salivary gland function, reduced salivary secretion and reduced oral cleaning ability with age, so dry mouth and halitosis are easily generated. Dry mouth is a symptom caused by lack of saliva in the oral cavity, and due to reduced salivation, a patient feels dry in the oral cavity, has a foreign body sensation and burning sensation, and cannot form food masses to affect swallowing when chewing food, particularly drier food. The salivary secretion is small, and the scouring effect on teeth and oral mucosa is also small, so that the self-cleaning effect of the oral cavity is poor. Saliva production and secretion is affected by factors of the whole body, local, external and self. The variety and quantity of bacteria in the mouth may change due to metabolic disorders, and dry mouth malodor may also be caused.

When the oral cavity is dry, food and bacteria adhere to the tooth surface, so that plaque formation is promoted, meanwhile, the pH value of the oral cavity is reduced, the caries risk is increased, the oral cavity flora is changed, and pathogenic bacteria related to caries occurrence, such as streptococcus mutans and actinomycetes, are obviously increased when the proportion of the pathogenic bacteria is normal.

Therefore, a material body with the effect of relieving dry mouth and halitosis of middle-aged and elderly people is needed.

Disclosure of Invention

The invention aims to provide a functional material body containing composite hydroxyapatite for relieving dry mouth halitosis of middle-aged and elderly people and a preparation method thereof, and the prepared functional material body has a good effect of relieving dry mouth halitosis.

The aim of the invention can be achieved by the following technical scheme:

The functional material body containing the composite hydroxyapatite for relieving the dry mouth halitosis of the middle-aged and elderly people comprises the following raw materials, by weight, 10-15 parts of deionized water, 0.1-0.3 part of a sweetener, 2-3 parts of a surfactant, 3-5 parts of glycerol, 30-35 parts of a humectant, 0.6-1 part of a thickener, 3-5 parts of trehalose, 25-35 parts of the composite hydroxyapatite, 0.1-0.2 part of superoxide dismutase and 0.1-0.2 part of glucanase;

The preparation process of the composite hydroxyapatite comprises the following steps:

s1, preparing hydroxyapatite:

s1.1, dissolving calcium salt in water, preparing to obtain a calcium-containing solution with the mass fraction of 10-15%, and regulating the pH value of the solution to 8-10 by using alkali to obtain a solution A;

S1.2, adding ammonium dihydrogen phosphate into the solution A, heating to 40-60 ℃, and stirring for 30-60 min to obtain a solution B, wherein the weight ratio of the ammonium dihydrogen phosphate to the solution A in the solution B is (3-5) (90-100);

S1.3, pouring the solution B into a reaction kettle, stirring for 18-25 hours at 120-150 ℃, washing the obtained substance with deionized water and absolute ethyl alcohol, and drying for 8-12 hours in a constant temperature drying oven at 55-70 ℃ to obtain hydroxyapatite;

S2, preparing modified hydroxyapatite:

Mixing menthol, clove oil and absolute ethyl alcohol in a volume ratio of (15-20), (4-6) and (45-55) to obtain a mixed solution, adding hydroxyapatite, stirring for 10-12 hours at 55-65 ℃, steaming for 1-2 hours, washing with deionized water, and drying for 8-10 hours at 65-75 ℃ to obtain modified hydroxyapatite;

s3, preparing composite hydroxyapatite:

Dispersing modified hydroxyapatite in deionized water, adding high methoxyl pectin after ultrasonic treatment for 15min, stirring for 1-2 h at a rotating speed of 200r/min, adding hydroxyethyl cellulose to increase the rotating speed to 300-400 r/min, continuously stirring for 2-4 h, drying for 10-14 h in a 45-50 ℃ vacuum drying oven, ball milling the obtained solid by a ball mill, and sieving with a 200-mesh sieve to obtain the composite hydroxyapatite, wherein the mass ratio of the modified hydroxyapatite to the hydroxyethyl cellulose to the high methoxyl pectin to the deionized water is (15-25): (3-6): (2-5): 100.

As a preferable technical scheme of the invention, the thickener is one of polyvinylpyrrolidone, xanthan gum and cellulose gum.

As a preferable technical scheme of the invention, the humectant is one or two of sorbitol and polyethylene glycol-8.

As a preferable technical scheme of the invention, the surfactant is one of sodium lauroyl sarcosinate and lauryl alcohol.

In a preferred embodiment of the present invention, the sweetener is one of sodium saccharin and stevia extract.

In a preferred embodiment of the present invention, in step S1.1, the calcium salt is one of calcium nitrate tetrahydrate and calcium chloride.

As a preferable technical scheme of the invention, in the step S1.1, the alkali is sodium hydroxide aqueous solution with the concentration of 1 mol/L.

As a preferable technical scheme of the invention, in the step S2, the weight-volume ratio of the hydroxyapatite to the mixed solution is 1 (18-20) g/mL.

As a preferable technical scheme of the invention, in the step S3, the ball milling condition is that the ball milling is carried out at a rotating speed of 400r/min for 3 hours.

The preparation method of the functional material body containing the composite hydroxyapatite for relieving the dry mouth halitosis of the middle-aged and the elderly comprises the following preparation processes:

Mixing sweetener, surfactant and deionized water according to parts by weight, stirring and dissolving to obtain a mixture A, adding humectant, glycerol and thickener, stirring at a rotating speed of 250r/min for 70-100 min to obtain a mixture B, mixing the mixture A and the mixture B, adding superoxide dismutase and glucanase, stirring at a rotating speed of 350r/min for 60-90 min to obtain a mixture C, continuously adding composite hydroxyapatite and trehalose into the mixture C, and stirring under a vacuum condition for 30-60 min to obtain the efficacy material containing the composite hydroxyapatite and capable of relieving mouth dryness and halitosis of middle-aged and elderly people.

The hydroxyapatite has excellent adsorption performance, can be quickly combined with bacteria and halitosis-causing chemical substances (such as hydrogen sulfide, methyl mercaptan and the like) in the oral cavity, and is discharged through rinsing, so that the oral cavity is cleaned, and halitosis is reduced. Meanwhile, the hydroxyapatite can effectively inhibit harmful bacteria causing halitosis in the oral cavity, such as gingiva porphyrin bacteria, spirochete and other anaerobic bacteria, and the hydroxyapatite is helpful for preventing and relieving periodontal diseases and further reducing halitosis by inhibiting the growth and propagation of the harmful bacteria.

Menthol can effectively neutralize the peculiar smell in the mouth, make the breath fresh and pleasant, and promote salivary secretion, thereby helping to reduce bacteria in the oral cavity and relieve halitosis and dry mouth. The clove oil has the functions of sterilization, anti-inflammation and the like, has obvious inhibition effect on various pathogenic fungi and bacteria, and can reduce the peculiar smell generated by the bacteria by killing or inhibiting the bacteria in the oral cavity, thereby achieving the effect of removing halitosis.

The hydroxyapatite is prepared by reacting calcium salt with monoammonium phosphate under the action of alkali, the hydroxyapatite is used as a carrier, the hydroxyapatite carrier is soaked in a solution containing menthol and clove oil by adopting an impregnation method, so that menthol and clove oil molecules fully permeate into the interior and the surface of the carrier, and meanwhile, organic molecules can be loaded on the porous structure surface of the hydroxyapatite in an adsorption mode. After menthol, clove oil and hydroxyapatite are combined, the synergistic effect can be exerted to mutually enhance the mutual effect, and the problem of halitosis can be effectively improved.

And when the hydroxyethyl cellulose molecules are added into the liquid, the hydroxyethyl cellulose is used as a high polymer material, the high polymer material has good film forming property and adhesiveness, the hydroxyethyl cellulose molecules can gather towards the surface due to the influence of solubility and molecular arrangement, and on the surface structure, the hydrophilic property of the hydroxyl groups enables the hydroxyethyl cellulose molecules to quickly form hydrogen bonds with water molecules, so that uniform distribution is formed on the surface of the modified hydroxyapatite, and the high methoxyl pectin is added first, so that the high methoxyl pectin has excellent moisturizing property and emulsion stability, the film forming effect can be further enhanced, the film is more stable, the molecular structure of the high methoxyl pectin contains a large number of hydroxyl groups, carboxyl groups and the like, and can interact with calcium ions and phosphate ions on the surface of the hydroxyapatite, and the interaction is favorable for promoting the tight combination of the film and the hydroxyapatite.

Meanwhile, the high methoxyl pectin contains more polar groups and has stronger hydrophilic performance, so that the high methoxyl pectin has good compatibility with water in the use process, and various components in the high methoxyl pectin are continuously released in the friction process, so that the halitosis dry mouth relieving effect of the material is improved.

Superoxide dismutase is an antioxidant component in toothpaste, and can remove free radicals in oral cavity, and protect teeth from oxidative damage. Glucanases also inhibit new plaque formation by breaking down glucans, helping to keep teeth clean and shiny.

Trehalose can adsorb and lock moisture, forms the protective layer, reduces the evaporation of moisture to help keeping the moist state of oral cavity, alleviate dry mouth symptom, the trehalose helps maintaining the integrality and the stability of oral mucosa cell, strengthens the barrier function of oral mucosa, further reduces the uncomfortable sense that dry mouth brought.

The invention has the beneficial effects that:

The invention prepares the hydroxyapatite through the reaction of calcium salt and monoammonium phosphate under the action of alkali, and carries out modification treatment on the hydroxyapatite through a solution impregnation method, and the prepared composite hydroxyapatite has the effect of relieving dry mouth halitosis under the mixing of other auxiliary agents.

Detailed Description

In order to further describe the technical means and effects adopted by the present invention for achieving the intended purpose, the following detailed description is given below with reference to the embodiments, structures, features and effects according to the present invention.

In the following examples and comparative examples:

hydroxyapatite, available from Shanghai Kanglang Biotechnology Co., ltd., product number: KL811001;

Saccharin sodium, purchased from Shanghai Hui Chu chemical technology limited;

Sodium lauroyl sarcosinate available from Tesco chemical (Hubei) Co., ltd;

sorbitol, purchased from Shandong Hunting biotechnology Co., ltd;

superoxide dismutase, commercially available from Shanghai Hui Cheng Biotechnology Co., ltd;

cellulose gum, available from Anhui Runtai Biotech Co., ltd;

calcium nitrate tetrahydrate, available from Shanghai Seikovia biotechnology Co., ltd;

Monoammonium phosphate available from Shanghai Yi vast chemical technology Co., ltd., product number: PA01732;

Menthol, available from Hubei Xinkang pharmaceutical chemical Co., ltd;

clove oil purchased from fomes chemical reagent company;

High methoxyl pectin, available from Wuhan energy kernel pharmaceutical chemical Co., ltd;

hydroxyethyl cellulose available from Shenzhen, boshuchemical Co., ltd;

Glycerol, available from Nantong Runfeng petrochemical Co., ltd;

glucanase from Shanghai derived leaf Biotechnology Co., ltd;

trehalose, commercially available from Shanghai Seikovia Biotechnology Co.

Example 1

Preparation of composite hydroxyapatite:

s1, preparing hydroxyapatite:

S1.1, dissolving calcium nitrate tetrahydrate in water, preparing to obtain a calcium-containing solution with the mass fraction of 10%, and regulating the pH value of the solution to 8 by using a sodium hydroxide aqueous solution with the concentration of 1mol/L to obtain a solution A;

S1.2, adding ammonium dihydrogen phosphate into the solution A, heating to 40 ℃, and stirring for 30min to obtain a solution B, wherein the weight ratio of the ammonium dihydrogen phosphate to the solution A in the solution B is 3:90;

S1.3, pouring the solution B into a reaction kettle, stirring for 18 hours at 120 ℃, washing the obtained substance with deionized water and absolute ethyl alcohol, and drying for 8 hours in a 55 ℃ constant temperature drying oven to obtain hydroxyapatite;

S2, preparing modified hydroxyapatite:

Mixing menthol, clove oil and absolute ethyl alcohol in a volume ratio of 15:4:45 to obtain a mixed solution, adding hydroxyapatite, wherein the weight-volume ratio of the hydroxyapatite to the mixed solution is 1:18g/mL, stirring for 10 hours at 55 ℃, spin-steaming for 1 hour, washing with deionized water, and drying for 8 hours at 65 ℃ to obtain modified hydroxyapatite;

s3, preparing composite hydroxyapatite:

Dispersing modified hydroxyapatite in deionized water, adding high methoxyl pectin after ultrasonic treatment for 15min, stirring for 1h at a rotating speed of 200r/min, adding hydroxyethyl cellulose to increase the rotating speed to 300r/min, continuously stirring for 2h, drying in a 45 ℃ vacuum drying oven for 10h, grinding the obtained solid at a rotating speed of 400r/min for 3h by a ball mill, and sieving the ground solid with a 200-mesh sieve to obtain the composite hydroxyapatite, wherein the mass ratio of the modified hydroxyapatite to the hydroxyethyl cellulose to the high methoxyl pectin to the deionized water is 15:3:2:100.

Preparation of an efficacy material body containing composite hydroxyapatite for relieving mouth dryness and halitosis of middle-aged and elderly people:

According to the parts by weight, 10 parts of deionized water, 0.1 part of saccharin sodium and 2 parts of lauroyl sarcosine sodium are fully mixed, stirred and dissolved to obtain a mixture A, 3 parts of glycerin, 30 parts of sorbitol and 0.6 part of cellulose gum are added, stirring is carried out for 70min at a rotating speed of 250r/min to obtain a mixture B, 0.1 part of superoxide dismutase and 0.1 part of glucanase are added after the mixture A and the mixture B are mixed, stirring is carried out for 60min at a rotating speed of 350r/min to obtain a mixture C, 3 parts of trehalose and 25 parts of composite hydroxyapatite are continuously added into the mixture C, and stirring is carried out for 30min under a vacuum condition to obtain the functional material body containing the composite hydroxyapatite for relieving mouth dry halitosis of middle-aged and elderly people.

Example 2

Preparation of composite hydroxyapatite:

s1, preparing hydroxyapatite:

S1.1, dissolving calcium nitrate tetrahydrate in water, preparing to obtain a calcium-containing solution with the mass fraction of 13%, and regulating the pH value of the solution to 9 by using a sodium hydroxide aqueous solution with the concentration of 1mol/L to obtain a solution A;

s1.2, adding ammonium dihydrogen phosphate into the solution A, heating to 50 ℃, and stirring for 40min to obtain a solution B, wherein the weight ratio of the ammonium dihydrogen phosphate to the solution A in the solution B is 4:95;

s1.3, pouring the solution B into a reaction kettle, stirring for 22 hours at 130 ℃, washing the obtained substance with deionized water and absolute ethyl alcohol, and drying for 10 hours in a 60 ℃ constant temperature drying oven to obtain hydroxyapatite;

S2, preparing modified hydroxyapatite:

Mixing menthol, clove oil and absolute ethyl alcohol in a volume ratio of 18:5:50 to obtain a mixed solution, adding hydroxyapatite, wherein the weight-volume ratio of the hydroxyapatite to the mixed solution is 1:19g/mL, stirring for 11h at 60 ℃, spin-steaming for 1.5h, washing with deionized water, and drying for 9h at 70 ℃ to obtain modified hydroxyapatite;

s3, preparing composite hydroxyapatite:

Dispersing modified hydroxyapatite in deionized water, adding high methoxyl pectin after ultrasonic treatment for 15min, stirring for 1.5h at a rotating speed of 200r/min, adding hydroxyethyl cellulose to increase the rotating speed to 350r/min, continuously stirring for 3h, drying for 12h in a 48 ℃ vacuum drying oven, grinding the obtained solid by a ball mill at a rotating speed of 400r/min for 3h, and sieving by a 200-mesh sieve to obtain the composite hydroxyapatite, wherein the mass ratio of the modified hydroxyapatite, the hydroxyethyl cellulose, the high methoxyl pectin and the deionized water is 20:5:3:100.

13 parts of deionized water, 0.2 part of saccharin sodium and 2.5 parts of lauroyl sarcosine sodium are fully mixed according to parts by weight, stirred and dissolved to obtain a mixture A, 4 parts of glycerin, 33 parts of sorbitol and 0.8 part of cellulose gum are added, stirring is carried out for 80 minutes at a rotating speed of 250r/min to obtain a mixture B, 0.15 part of superoxide dismutase and 0.15 part of glucanase are added after the mixture A is mixed with the mixture B, stirring is carried out for 80 minutes at a rotating speed of 350r/min to obtain a mixture C, 4 parts of trehalose and 30 parts of composite hydroxyapatite are continuously added into the mixture C, and stirring is carried out for 50 minutes under a vacuum condition to obtain the functional material body containing the composite hydroxyapatite for relieving mouth dryness halitosis of middle aged people.

Example 3

Preparation of composite hydroxyapatite:

s1, preparing hydroxyapatite:

S1.1, dissolving calcium nitrate tetrahydrate in water, preparing to obtain a calcium-containing solution with the mass fraction of 15%, and regulating the pH value of the solution to 10 by using a sodium hydroxide aqueous solution with the concentration of 1mol/L to obtain a solution A;

S1.2, adding ammonium dihydrogen phosphate into the solution A, heating to 60 ℃, and stirring for 60min to obtain a solution B, wherein the weight ratio of the ammonium dihydrogen phosphate to the solution A in the solution B is 5:100;

S1.3, pouring the solution B into a reaction kettle, stirring for 25 hours at 150 ℃, washing the obtained substance with deionized water and absolute ethyl alcohol, and drying for 12 hours in a 70 ℃ constant temperature drying oven to obtain hydroxyapatite;

S2, preparing modified hydroxyapatite:

Mixing menthol, clove oil and absolute ethyl alcohol in a volume ratio of 20:6:55 to obtain a mixed solution, adding hydroxyapatite, wherein the weight-volume ratio of the hydroxyapatite to the mixed solution is 1:20g/mL, stirring for 12 hours at 65 ℃, steaming for 2 hours, washing with deionized water, and drying for 10 hours at 75 ℃ to obtain modified hydroxyapatite;

s3, preparing composite hydroxyapatite:

Dispersing modified hydroxyapatite in deionized water, adding high methoxyl pectin after ultrasonic treatment for 15min, stirring for 2h at a rotating speed of 200r/min, adding hydroxyethyl cellulose to increase the rotating speed to 400r/min, continuously stirring for 4h, drying in a 50 ℃ vacuum drying oven for 14h, grinding the obtained solid at the rotating speed of 400r/min for 3h by a ball mill, and sieving the ground solid with a 200-mesh sieve to obtain the composite hydroxyapatite, wherein the mass ratio of the modified hydroxyapatite to the hydroxyethyl cellulose to the high methoxyl pectin to the deionized water is 25:6:5:100.

15 parts of deionized water, 0.3 part of saccharin sodium and 3 parts of lauroyl sarcosine sodium are fully mixed according to parts by weight, stirred and dissolved to obtain a mixture A, 5 parts of glycerin, 35 parts of sorbitol and 1 part of cellulose gum are added, stirring is carried out for 100min at a rotating speed of 250r/min to obtain a mixture B, 0.2 part of superoxide dismutase and 0.2 part of glucanase are added after the mixture A is mixed with the mixture B, stirring is carried out for 90min at a rotating speed of 350r/min to obtain a mixture C, 5 parts of trehalose and 35 parts of composite hydroxyapatite are continuously added into the mixture C, and stirring is carried out for 60min under a vacuum condition to obtain the efficacy material containing the composite hydroxyapatite for relieving mouth dryness halitosis of middle-aged and elderly people.

Comparative example 1

Comparative example 1 is different from example 1 in that the preparation process of the composite hydroxyapatite in comparative example 1 is not treated by the step S2, and the rest operations are identical.

Comparative example 2

Comparative example 2 differs from example 1 in that high methoxyl pectin was not added during the preparation of the composite hydroxyapatite of comparative example 2, and the rest of the operations were identical.

Comparative example 3

Comparative example 3 is different from example 1 in that the preparation of the composite hydroxyapatite in comparative example 3 is not subjected to the treatment of step S3, and the rest of the operations are identical.

Comparative example 4

Comparative example 4 differs from example 1 in that the hydroxyapatite of comparative example 4 was not subjected to the steps S2 and S3, and the remaining operations were identical.

Performance test:

The functional material body containing the composite hydroxyapatite for relieving the dry mouth halitosis of the middle-aged and the elderly can be directly used as toothpaste.

1. Halitosis test:

140 men and women with bad breath at ages 50-67 are selected as study subjects, and the study subjects are randomly and evenly divided into 7 groups of 20 persons according to the breath value, sex and age before the test.

The test requirements and the judgment method are that the toothpaste prepared in the examples 1-3 and the toothpaste prepared in the comparative examples 1-4 are extruded on the toothbrush by a test person, so that the tooth brushing time of 2 minutes is ensured. The Halimer breath detector is used for expressing the concentration of volatile sulfide in the oral gas in a numerical form by utilizing an electrochemical principle, and can be used as an index for measuring the oral gas level of a patient. Testing the average breath value of 20 persons in each group after brushing for 5min, the average breath value after brushing for 30min, the average breath value after brushing for 60min, the average breath value after brushing for 120min, and calculating the breath drop rate to judge the halitosis eliminating effect according to the difference between the average breath value before brushing and the average breath value after brushing for 5min, 30min, 60min and 120min, and the results are shown in the following table 1;

Breath decrease rate (%) = difference in average breath value/average breath value before brushing;

TABLE 1

As can be seen from the above data, the rate of decrease in breath in each period of examples 1 to 3 is significantly higher than that of comparative examples 1 to 4, indicating that the functional material prepared in examples has an important effect on removal of breath.

2. Dry mouth test:

the experimental method is that 70 patients with xerostomia are summoned, and the case inclusion standard and the exclusion standard are that Western diagnosis meets the 2002 SS international classification standard (AECG standard), and the case exclusion standard refers to the clinical study guidelines for treating Sjogren syndrome by Chinese medicine. The age is 50-75 years, no other systemic diseases exist, the swallowing function is normal, and no oral ulcer and salivary gland disease history exist.

70 Patients were randomly divided into 7 groups (10 persons in each of examples 1-3 and comparative examples 1-4) and each were brushed 2 times a day and a night with test samples for 3 minutes each, and the daily intake of water was maintained at 1500mL for 28 days, and the two groups of patients were observed for changes in dry mouth.

The dry mouth condition of the subject is observed by adopting a Visual Analysis Scale (VAS) scoring method, the patient scores the problems of dry mouth, oral comfort, speaking ability, chewing and swallowing ability, sleeping and the like according to subjective feeling on a Visual Analysis Scale (VAS) with the length of 100mm, one end of the scale marks negative symptoms such as dryness, discomfort or difficulty in scoring 100 points, and the other end of the scale marks positive symptoms such as non-dryness, comfort or fluency and the like scoring 0 points.

The positions are marked on the scale according to the degree of symptoms, and the scoring method is applied to record the scores of the subjects after 28 days of using the test toothpaste before using the toothpaste, and the scoring results of the xerostomia VAS method after 28 days of using the test toothpaste are shown in the following table 2:

TABLE 2

From the above data, it can be seen that the dry mouth of the subjects was relieved and the oral comfort was also improved to some extent after using examples 1-3 of the present invention. Meanwhile, the dry mouth VAS scores in comparative examples 1 to 4 are significantly higher than those in examples 1 to 3, and P <0.05. The effect material prepared by the invention has the effect of relieving dry mouth and bad breath of middle-aged and elderly people.

The present invention is not limited in any way by the above-described preferred embodiments, but is not limited to the above-described preferred embodiments, and any person skilled in the art will appreciate that the present invention can be embodied in the form of a program for carrying out the method of the present invention, while the above disclosure is directed to equivalent embodiments capable of being modified or altered in some ways, it is apparent that any modifications, equivalent variations and alterations made to the above embodiments according to the technical principles of the present invention fall within the scope of the present invention.

Claims

1. A functional material containing composite hydroxyapatite for alleviating dry mouth and halitosis in the middle-aged and elderly, characterized in that it comprises the following raw materials in parts by weight: 10-15 parts of deionized water, 0.1-0.3 parts of sweetener, 2-3 parts of surfactant, 3-5 parts of glycerol, 30-35 parts of humectant, 0.6-1 parts of thickener, 3-5 parts of trehalose, 25-35 parts of composite hydroxyapatite, 0.1-0.2 parts of superoxide dismutase and 0.1-0.2 parts of glucanase;

The preparation process of the composite hydroxyapatite is as follows:

S1. Preparation of hydroxyapatite:

S1.1. Dissolve calcium salt in water to prepare a calcium solution with a mass fraction of 10-15%, and adjust the pH value of the solution to 8-10 with alkali to obtain solution A;

S1.2, add ammonium dihydrogen phosphate to solution A, heat to 40-60°C, and stir for 30-60 min to obtain solution B, wherein the weight ratio of ammonium dihydrogen phosphate in solution B to solution A is (3-5): (90-100);

S1.3, pour solution B into the reactor, stir at 120-150°C for 18-25h, wash the obtained substance with deionized water and anhydrous ethanol, dry it in a constant temperature drying oven at 55-70°C for 8-12h, grind the dried solid with a ball mill at a speed of 400r/min for 3h, and then pass it through a 200-mesh sieve to obtain hydroxyapatite;

S2. Preparation of modified hydroxyapatite:

Mix menthol: clove oil: anhydrous ethanol in a volume ratio of (15-20): (4-6): (45-55) to obtain a mixed solution, add hydroxyapatite, stir at 55-65°C for 10-12 hours, perform rotary evaporation for 1-2 hours, wash with deionized water, and dry at 65-75°C for 8-10 hours to obtain modified hydroxyapatite;

S3. Preparation of composite hydroxyapatite:

The modified hydroxyapatite is dispersed in deionized water, ultrasonically treated for 15 minutes, and then high methoxy pectin is added. After stirring at a speed of 200 r/min for 1-2 hours, hydroxyethyl cellulose is added and the speed is increased to 300-400 r/min and stirring is continued for 2-4 hours. The mixture is dried in a vacuum drying oven at 45-50° C. for 10-14 hours. The obtained solid is ball-milled in a ball mill and then sieved through a 200-mesh sieve to obtain the composite hydroxyapatite, wherein the mass ratio of the modified hydroxyapatite, hydroxyethyl cellulose, high methoxy pectin and deionized water is (15-25):(3-6):(2-5):100.

2. The functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in the middle-aged and elderly according to claim 1, characterized in that the thickener is one of polyvinyl pyrrolidone, xanthan gum and cellulose gum.

3. The functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in the middle-aged and elderly according to claim 1, characterized in that the moisturizing agent is one or both of sorbitol and polyethylene glycol-8.

4. The functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in the middle-aged and elderly according to claim 1, characterized in that the surfactant is one of sodium lauroyl sarcosinate and lauryl alcohol.

5. The functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in the middle-aged and elderly according to claim 1, characterized in that the sweetener is one of saccharin sodium and stevia extract.

6. The functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in the middle-aged and elderly according to claim 1, characterized in that in step S1.1, the calcium salt is one of calcium nitrate tetrahydrate and calcium chloride.

7. The functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in the middle-aged and elderly according to claim 1, characterized in that in step S1.1, the alkali is a sodium hydroxide aqueous solution with a concentration of 1 mol/L.

8. The functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in the middle-aged and elderly according to claim 1, characterized in that in step S2, the weight volume ratio of the hydroxyapatite to the mixed solution is 1: (18-20) g/mL.

9. The functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in the middle-aged and elderly according to claim 1, characterized in that in step S3, the ball milling condition is grinding at a rotation speed of 400 r/min for 3 hours.

10. A method for preparing a functional material containing composite hydroxyapatite for alleviating dry mouth and bad breath in the elderly as claimed in any one of claims 1 to 9, characterized in that it comprises the following preparation process:

The sweetener, surfactant and deionized water are fully mixed by weight, stirred and dissolved to obtain a mixture A, and then a humectant, glycerin and a thickener are added, and the mixture is stirred at a speed of 250 r/min for 70 to 100 minutes to obtain a mixture B; after the mixture A and the mixture B are mixed, superoxide dismutase and glucanase are added, and the mixture is stirred at a speed of 350 r/min for 60 to 90 minutes to obtain a mixture C; the composite hydroxyapatite and trehalose are continuously added to the mixture C, and the mixture is stirred under vacuum conditions for 30 to 60 minutes to obtain the functional material containing the composite hydroxyapatite for alleviating dry mouth and bad breath in the middle-aged and elderly.