CN119184929A

CN119184929A - Medicine support for rapidly treating intracranial vascular stenosis

Info

Publication number: CN119184929A
Application number: CN202411411207.8A
Authority: CN
Inventors: 曾凡艳; 王国辉; 李志刚
Original assignee: Shanghai Xinwei Medical Technology Co ltd
Current assignee: Shanghai Xinwei Medical Technology Co ltd
Priority date: 2024-10-10
Filing date: 2024-10-10
Publication date: 2024-12-27

Abstract

The invention provides a cutting braided stent, which belongs to the technical field of medical appliances for treating vascular diseases, and comprises a vascular stent, wherein a medicine carrying groove for containing medicines is formed in the outer surface of the vascular stent, a slow-release capsule is fixedly arranged in the medicine carrying groove, the slow-release capsule is provided with a shell, a containing cavity is formed in the shell, medicine particles and a shell breaking component are loaded in the containing cavity of part of the slow-release capsule, the medicine component for rapidly treating intracranial vascular stenosis further comprises a driving component, the driving component is arranged outside a body and used for driving the shell breaking component to rapidly break the shell so as to rapidly release the medicine particles in the shell, and the medicine component is mainly used for solving the technical problem that the medicine eluting stent in the prior art cannot rapidly release medicines so as not to rapidly produce a therapeutic effect.

Description

Medicine support for rapidly treating intracranial vascular stenosis

Technical Field

The invention belongs to the technical field of medical equipment for nerve intervention operation, and particularly relates to a drug stent for rapidly treating intracranial vascular stenosis.

Background

In the field of medical interventions, it is currently widely used to treat intracranial vascular stenosis by Drug-eluting stents (Drug-Eluting Stent, DES). DES is a medical device integrating advanced material science and drug delivery technology, and is characterized in that a metal stent substrate is covered with a layer of antiproliferative drugs (such as rapamycin, paclitaxel derivatives, etc.). These drugs undergo a gradual release process after successful stent implantation into the vascular lesion site, aimed at inhibiting the hyperproliferation of vascular smooth muscle cells, thereby reducing the incidence of restenosis (ISR) within the stent.

Although DES exhibits significant efficacy in reducing ISR, slow release of drug from a drug eluting stent does not provide rapid therapeutic benefit and thus rapid control of the condition in patients who need urgent control of symptoms or exacerbations of the condition.

Accordingly, there is a need to provide an improved solution to the above-mentioned deficiencies of the prior art.

Disclosure of Invention

The invention aims to provide a drug stent for rapidly treating intracranial vascular stenosis, which aims to solve the technical problem that a drug eluting stent in the prior art cannot rapidly release drugs so as not to rapidly generate a treatment effect.

In order to achieve the above object, the present invention provides a drug stent for rapidly treating intracranial vascular stenosis, comprising the following steps:

The utility model provides a quick treatment intracranial vascular stenosis's medicine subassembly, includes the vascular support, has the medicine carrying groove that is used for splendid attire medicine on the surface of vascular support, carries the fixed slow-release capsule that has set up in the medicine carrying groove, and slow-release capsule has the casing, and the casing is inside to have to hold the cavity, holds the cavity of partial slow-release capsule and is loaded with medicine granule and broken shell part, quick treatment intracranial vascular stenosis's medicine subassembly still includes drive part, drive part sets up and is used for driving broken shell part quick destruction casing in order to release the medicine granule in the casing rapidly outside the body.

As a further optimized technical scheme, the shell breaking component is a block-shaped component with magnetism, and the driving component is a magnetic device capable of attracting the shell breaking component.

As a further preferred embodiment, the block element has a spike, at least the spike having magnetic properties.

As a further optimized technical scheme, at least the outer side of the spike part is provided with a hydrophilic polymer coating, and after the shell breaking component breaks the shell and releases the shell into blood, the polymer coating rapidly reacts with moisture in the blood to generate a buffer layer for coating the puncture component.

As a further optimized technical scheme, the whole shell breaking part is in a cone shape, and the top end of the cone forms the spike part.

As a further optimized technical scheme, the whole shell breaking part is a rectangular pyramid, and the tip of the rectangular pyramid forms the spike part.

As a further optimized technical scheme, the shell breaking part is provided with a brittle coating shell, a counterweight magnet capable of being attracted by a magnetic field and a shell solution for dissolving the slow-release capsule are arranged in the brittle coating shell, and the driving part is magnetic equipment capable of attracting the counterweight magnet.

As a further optimized technical scheme, the counterweight magnet is in a sphere shape.

As a further optimized technical scheme, the magnetic device is an electromagnet and is used for controlling the magnetic field intensity of the electromagnet by controlling current.

As a further optimized technical scheme, the size of the slow-release capsule is 150-250 μm, and the length of the shell breaking component is 60-100 nm.

The application has the beneficial effects that firstly, the medicine carrying groove is formed on the outer surface of the vascular stent, then, the slow release capsule containing medicine is fixedly arranged in the medicine carrying groove, wherein part of the slow release capsule contains the shell breaking part, when the vascular stent is placed at a position of vascular stenosis, the shell breaking part is driven by the driving part to break the shell outside a patient, so that medicine particles in the slow release capsule are rapidly released into surrounding tissues, further, the situation of rapidly treating emergency symptoms can be realized, and the medicine particles are slowly released at the later stage of the slow release capsule without part of the shell breaking part, so that the position of a patient to be treated is continuously consolidated, and further, a good treatment effect is ensured.

Drawings

The accompanying drawings, which are included to provide a further understanding of the application and are incorporated in and constitute a part of this specification, illustrate embodiments of the application and together with the description serve to explain the application. Wherein:

FIG. 1 is a schematic overall structure of embodiment 1 of the present invention;

FIG. 2 is a schematic view showing the overall structure of a stent according to embodiment 1 of the present invention;

FIG. 3 is a schematic overall structure of embodiment 1 of the present invention;

FIG. 4 is a schematic overall structure of embodiment 1 of the present invention;

FIG. 5 is a schematic overall structure of embodiment 1 of the present invention;

fig. 6 is a schematic diagram showing the overall structure of a sustained-release capsule according to example 2 of the present invention.

In fig. 1-5, 1, a vascular stent, 2, a medicine carrying groove, 3, a slow release capsule, 301, a shell, 302, a containing cavity, 303, medicine particles, 304a, a shell breaking component and 4, a driving component;

in FIG. 6, 304b, a shell breaking component, 3041, a cladding shell, 3042 and a counterweight magnet.

Detailed Description

The following description of the technical solutions in the embodiments of the present invention will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which are derived by a person skilled in the art based on the embodiments of the invention, fall within the scope of protection of the invention.

In the description of the present invention, the terms "longitudinal", "transverse", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", etc. refer to the orientation or positional relationship based on that shown in the drawings, merely for convenience of description of the present invention and do not require that the present invention must be constructed and operated in a specific orientation, and thus should not be construed as limiting the present invention. The terms "coupled" and "connected" as used herein are to be construed broadly, and may be, for example, fixedly coupled or detachably coupled, or may be directly coupled or indirectly coupled through intermediate members, as will be apparent to those of ordinary skill in the art, in view of the detailed description of the terms.

The invention will be described in detail below with reference to the drawings in connection with embodiments. It should be noted that, without conflict, the embodiments of the present invention and features of the embodiments may be combined with each other.

According to the specific embodiment of the invention, the invention provides a medicine component for rapidly treating intracranial vascular stenosis, which is characterized in that a medicine carrying groove is formed on the outer surface of a vascular stent, a slow release capsule containing medicine is embedded and fixed in the medicine carrying groove, a shell breaking part for breaking the shell of the slow release capsule is contained in part of the slow release capsule, and a driving part arranged outside the body is matched, so that the shell breaking part pierces the shell of the slow release capsule, the medicine is rapidly released to tissues, and the illness state is conveniently and rapidly controlled.

Example 1

As shown in fig. 1 and 2, the drug component for rapidly treating intracranial vascular stenosis comprises a vascular stent 1, wherein the vascular stent 1 adopts a high surface area ratio grid design, such as a closed-loop asymmetric polygonal grid, and the design can increase the contact area between the vascular stent 1 and the vascular wall, thereby providing more drug release points and being beneficial to uniform distribution and rapid release of drugs.

As shown in fig. 3,4 and 5, the outer surface of the vascular stent 1 is provided with a medicine carrying groove 2 for containing medicines, a plurality of slow release capsules 3 are fixedly arranged in the medicine carrying groove 2 in an embedding way, each slow release capsule 3 is provided with a shell 301, the interior of the shell 301 is provided with a containing cavity 302, a part of the containing cavities 302 of the slow release capsules 3 are filled with medicine particles 303 and a shell breaking part 304a, the medicine component for rapidly treating intracranial vascular stenosis further comprises a driving part 4, and the driving part 4 is arranged outside the body and used for driving the shell breaking part 304a to rapidly break the shell 301 so as to rapidly release the medicine particles 303 in the shell 301.

In this embodiment, the breaking member 304a is a block member having magnetism, the driving member 4 is a magnetic device that attracts the breaking member 304a, and the magnetic device is an electromagnet for controlling the magnetic field strength of the electromagnet by controlling the current. In operation, the driving member 4 is placed outside the body and the intravascular stent 1 is applied in a non-invasive manner (e.g., against the scalp or an implantable subcutaneous device).

Specifically, when in use, the vascular stent 1 is released at a narrow position of a blood vessel, and then the shell breaking component 304a is attracted to impact and destroy the shell 301 of the slow release capsule 3 through the action of the magnetic equipment, so that the medicine particles 303 in the slow release capsule 3 are rapidly released, the emergency treatment on the position of worsening of the disease condition is completed, and the medicine is slowly released through the slow release capsule 3 without the shell breaking component 304a in the later period, so that the treatment effect is further consolidated.

To further enhance the treatment of the vascular severe patient sites, more sustained release capsules 3 containing the shell breaking members 304a may be secured to the corresponding vascular stent 1 segments.

In order to make it easier for the breaking member 304a to pierce the housing 301 of the slow release capsule 3, the breaking member 304a has a spike, the breaking member 304a may be magnetic as a whole, or at least the spike. When the electromagnet is operated, the attraction spike impacts against the housing 301 of the slow release capsule 3, so that the housing 301 is more easily damaged. In the present embodiment, the entire shell-breaking member 304a has a cone shape, and the tip of the cone forms a spike, and in other embodiments, the entire shell-breaking member 304a may have a rectangular pyramid shape, a spike formed by the tip of the rectangular pyramid shape, or the shell-breaking member 304a may have a structure having a vertex such as a polygonal pyramid shape.

Further, the size of the sustained-release capsule 3 is 150 μm to 250 μm (for example, 150 μm, 160 μm, 170 μm, 180 μm, 190 μm, 200 μm, 210 μm, 220 μm, 230 μm, 240 μm, 250 μm and the interval between any two points), the length of the shell-breaking member 304 is 60nm to 100nm (for example, 60nm, 70nm, 80nm, 90nm, 100nm and the interval between any two points), the size of the sustained-release capsule 3 and the shell-breaking member 304a is relatively small, and the shell-breaking member 304a with the spike portion is released directly into the blood vessel without causing bad damage to the blood vessel, but in order to further ensure the safety of the blood vessel, a hydrophilic polymer coating such as polyvinylpyrrolidone (PVP), polyacrylamide (PAM), polyethylene glycol (PEG), polyvinyl alcohol (PVA), natural polysaccharide and derivatives may be provided on the whole of the shell-breaking member 304a, or at least a hydrophilic polymer coating with a hydrophilic polymer coating outside the spike portion. In this way, when the shell breaking member 304a breaks the shell 301 and releases it into the blood, the polymer coating reacts rapidly with the moisture in the blood to create a buffer layer that encases the piercing member, which helps reduce the turbulence and turbulence of the blood caused by the burst, thereby reducing impact and damage to the vessel wall. The shell breaking member 304a is then finally expelled from the body as the blood circulates normally.

Example 2

The embodiment provides another form of shell breaking member, and other technical solutions in this embodiment are the same as those in embodiment 1, and are not described herein.

In this embodiment, as shown in fig. 6, the breaking member 304b has a brittle coating housing 3041, the brittle coating housing 3041 has therein a weight magnet 3042 that can be attracted by a magnetic field and a solution for dissolving the slow release capsule 3 housing 301, and the driving member 4 is a magnetic device that can attract the weight magnet 3042.

Thus, when the vascular stent 1 is released at the narrow position of the blood vessel, the counterweight magnet 3042 is attracted to carry the shell breaking part 304b to integrally strike the shell 301 of the slow release capsule 3 through the action of the magnetic device, then the brittle coating shell 3041 is broken, and the solution in the shell 301 for dissolving the slow release capsule 3 flows out to quickly dissolve the shell 301 of the slow release capsule 3, so that the drug particles 303 are released from the shell 301 to quickly inhibit illness.

Further, in order to avoid damaging the blood vessel by the weight magnet, the weight magnet 3042 is designed in a spherical shape. Meanwhile, the hydrophilic polymer coating layer of the same material as that of the embodiment 1 is coated on the coating housing 3041, so that when the coating housing 3041 is broken into blood, the polymer coating layer reacts with moisture in the blood rapidly to generate a buffer layer coating the puncture member, and the buffer layer helps to reduce damage of fragments of the coating housing 3041 to blood vessels.

In summary, according to the application, firstly, the drug carrying groove 2 is formed on the outer surface of the vascular stent 1, then the sustained release capsule 3 containing the drug is fixedly arranged in the drug carrying groove 2, wherein part of the sustained release capsule 3 contains the shell breaking parts 304a and 304b, when the vascular stent 1 is placed at the position of vascular stenosis, the shell breaking parts 304a and 304b are operated by the driving part 4 outside a patient body to break the shell 301, so that the drug particles in the sustained release capsule are rapidly released into surrounding tissues, thereby realizing rapid treatment of emergency symptoms, and the drug particles are slowly released in the later period of the sustained release capsule without the shell breaking part, so as to continuously consolidate the position of a patient to be treated, and further ensuring good treatment effect.

It is to be understood that the above description is intended to be illustrative, and that the embodiments of the present application are not limited thereto.

The foregoing description of the preferred embodiments of the invention is not intended to limit the invention to the particular embodiments disclosed, but on the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention as defined by the appended claims.

Claims

1. The utility model provides a quick treatment intracranial vascular stenosis's medicine subassembly, includes vascular support (1), its characterized in that has on the surface of vascular support (1) and is used for holding medicine carrier groove (2), carrier groove (2) internal fixation has laid slow release capsule (3), slow release capsule (3) have casing (301), casing (301) inside has holding cavity (302), in the holding cavity (302) of part slow release capsule (3) drug granule (303) and broken shell part (304 a,304 b), quick treatment intracranial vascular stenosis's medicine subassembly still includes drive part (4), drive part (4) set up and be used for driving broken shell part (304 a,304 b) quick destruction casing (301) in order to release drug granule (303) in casing (301) fast outside the body.

2. A pharmaceutical assembly for the rapid treatment of intracranial vascular stenosis according to claim 1, wherein the breaking member (304 a) is a block member having magnetic properties, and the driving member (4) is a magnetic device which attracts the breaking member (304 a).

3. The pharmaceutical assembly for rapid treatment of intracranial vascular stenosis as recited in claim 2, wherein the block member has a spike, at least the spike being magnetic.

4. A pharmaceutical assembly for rapid treatment of intracranial vascular stenosis as in claim 3, wherein at least the outer side of the spike is provided with a hydrophilic polymer coating, the breaking member (304 a) breaking the shell (301) releasing into the blood the polymer coating rapidly reacting with the moisture in the blood to create a buffer layer coating the piercing member.

5. A pharmaceutical assembly for rapid treatment of intracranial vascular stenosis as in claim 3, wherein the whole of the shell-disrupting member (304 a) is in the shape of a cone, the tip of the cone constituting the spike.

6. A pharmaceutical assembly for rapid treatment of intracranial vascular stenosis as in claim 3, wherein the said breaking member (304 a) is in the form of a square pyramid as a whole, the tip of which constitutes the said spike.

7. The drug assembly for rapid treatment of intracranial vascular stenosis according to claim 1, wherein the breaking member (304 b) has a brittle coated housing (3041), the brittle coated housing (3041) has a magnetically attractable counter-weight magnet (3042) and a solution for dissolving a slow release capsule (3) housing (301), the driving member (4) being a magnetic device that attracts the counter-weight magnet (3042) inside.

8. The pharmaceutical assembly for rapid treatment of intracranial vascular stenosis as recited in claim 7, wherein the weighted magnet (3042) is in the shape of a sphere.

9. The pharmaceutical assembly for rapid treatment of intracranial vascular stenosis as recited in claims 2-8, wherein the magnetic device is an electromagnet for controlling the magnetic field strength of the electromagnet by controlling the current.

10. A pharmaceutical assembly for the rapid treatment of intracranial vascular stenosis according to any of the claims 1 to 8, wherein the slow release capsule (3) has a size ranging from 150 to 250 μm and the shell-breaking member (304) has a length ranging from 60nm to 100nm.