CN119112681B - Toothpaste for resisting dentin sensitivity and preparation method thereof, and method for resisting dentin sensitivity - Google Patents
Toothpaste for resisting dentin sensitivity and preparation method thereof, and method for resisting dentin sensitivity Download PDFInfo
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- CN119112681B CN119112681B CN202411619693.2A CN202411619693A CN119112681B CN 119112681 B CN119112681 B CN 119112681B CN 202411619693 A CN202411619693 A CN 202411619693A CN 119112681 B CN119112681 B CN 119112681B
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- dentin
- toothpaste according
- sensitivity
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- 238000002360 preparation method Methods 0.000 title claims abstract description 10
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- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
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- QTPSOVJLZXSTEB-UHFFFAOYSA-L calcium;dodecyl sulfate Chemical compound [Ca+2].CCCCCCCCCCCCOS([O-])(=O)=O.CCCCCCCCCCCCOS([O-])(=O)=O QTPSOVJLZXSTEB-UHFFFAOYSA-L 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
- A47K—SANITARY EQUIPMENT NOT OTHERWISE PROVIDED FOR; TOILET ACCESSORIES
- A47K5/00—Holders or dispensers for soap, toothpaste, or the like
- A47K5/18—Holders or dispensers for soap, toothpaste, or the like for both soap and toothpaste or the like; in combination with holders for drinking glasses, toothbrushes, or the like ; Toothpaste dispensers; Dental care centers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D35/00—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor
- B65D35/22—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor with two or more compartments
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D35/00—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor
- B65D35/24—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor with auxiliary devices
- B65D35/28—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor with auxiliary devices for expelling contents
- B65D35/30—Pistons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
- A61K2800/882—Mixing prior to application
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- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dentistry (AREA)
- Cosmetics (AREA)
Abstract
The application relates to the field of oral care, and relates to dentin-sensitivity-resistant toothpaste, a preparation method thereof and a dentin-sensitivity-resistant method. The toothpaste for preventing dentin sensitivity comprises an extrusion container, a first paste and a second paste, wherein the extrusion container comprises a container body, at least two subchambers are arranged along the extending direction of the container body, the first paste and the second paste are respectively contained in one subchamber, the first paste comprises bioactive glass, and the second paste comprises water. When the dental cream is used, the first cream and the second cream are contacted and mixed, water rapidly activates the bioactive glass to release the activity, and the activated bioactive glass can target mineralization to block the exposed dentin, so that the problem of dentin sensitivity is fundamentally improved.
Description
Technical Field
The application relates to the field of oral care, in particular to dentin-sensitivity-resistant toothpaste, a preparation method thereof and a dentin-sensitivity-resistant method.
Background
According to the research of the second adult dentin sensitivity and dental abrasion epidemiology in 2021, the prevalence rate of dentin sensitivity reaches 36.7%. That is, one person among 3 persons is bothered by the problem of tooth sensitivity and toothache, and the number of sensitive teeth of people per country is up to 1.5. And once a tooth sensitivity problem occurs, the duration of symptoms is generally longer. The chronic pain caused by tooth sensitivity can reduce our quality of life silently.
The tissue structure of human teeth from outside to inside consists of enamel, dentin, cementum and pulp 4. Enamel is a semitransparent calcified tissue, covers the crown surface of teeth, is milky or yellowish, and is formed by combining innumerable dense enamel columns and a small number of column interstitials. Enamel at different positions has different thickness, the tooth tip can reach 2.5mm, the tooth tip gradually thins to the jaw part, and the tooth neck part is thinnest, about 2mm. Our outermost layer of each tooth is wrapped around highly mineralized enamel, the most rigid tissue in the human body, and is also the "tooth barrier". Enamel, while hard, is not without firmness. The habit of grinding, acid and brittleness, wrong tooth brushing, tooth grinding at night, eating hard food, drinking acidic beverage and the like can lead to the enamel to be worn and thinner until dentin is exposed in the oral cavity. When dentin is exposed to the oral cavity, tooth sensitivity problems arise. Dentin is the main part of the tooth, is a highly mineralized special tissue, occupies the main part of the tooth tissue, and forms the outer wall of the pulp cavity. The dentin of the crown is covered with enamel and the root is covered with cementum. Dentin consists of a matrix and dentinal tubules, in which there are cell processes from odontoblasts, whereby the nutrient metabolism is performed. Dentin calcification degree and hardness are slightly lower than enamel, light yellow, opaque, inorganic salt accounting for about 70%, mainly hydroxyapatite, calcium phosphate, etc., and organic matters accounting for about 30%, mainly collagen. The fluid flowing in the dentinal tubules may transmit signals from the outside to the pulp nerve of the inner layer. Ice, heat, sweetness, acids, mechanical stimuli, etc. all alter the flow of liquid in the dentinal tubules. These small movements are rapidly transmitted to the pulp, activate pulp nerve fibers, and cause a burst of short and sharp pain. When dentin is exposed, dentinal tubules are particularly vulnerable to irritation and dental pain occurs particularly frequently.
Dentin hypersensitivity is a symptom of teeth suffering from external stimuli such as acid, softness, pain, etc. caused by temperature (cold, hot), chemical substances (sour, sweet), mechanical action (friction or biting) etc. Dentin hypersensitivity is frequently-occurring and frequently-occurring oral diseases, and has a relatively high incidence rate for adults, and is a main cause of toothache in clinic.
The mechanism of dentin hypersensitivity is mainly three theories, namely ① neurotheory that dentin is considered to exist in pulpal nerve endings, sensation is generated by conducting human dental pulp from dentin surface layers, ② dentin fiber conduction theory that the protoplasm process forming dentin cells contains acetylcholinesterase, nerve conduction can be caused after the stimulation, pain is generated, and ③ hydrodynamic theory that external stimulation is considered to drive liquid flow in dentinal tubules, and the flowing liquid stimulates peripheral nerves in dental pulp and dentinal kingdom, so that characteristic clinical symptoms are caused. Hydrodynamic theory is the most widely accepted theory of dentinal sensitivity mechanisms. According to the theory, the effective treatment method for dentin hypersensitive symptoms comprises the steps of firstly, calming dental pulp nerves, reducing sensitivity of dentin and dental pulp nerve endings, thereby relieving pain symptoms caused by dentin hypersensitiveness (treating symptoms), and secondly, closing dentin tubules, reducing permeability of dentin, and reducing or avoiding liquid flow in dentin (treating root causes).
The existing commercial dentine hypersensitivity resistant toothpaste or oral desensitizing paste is mainly the desensitizing toothpaste containing desensitizing agents such as strontium chloride, potassium nitrate, fluoride and hydroxyapatite, however, the desensitizing toothpaste can only realize the purpose of treating both symptoms and root causes.
Disclosure of Invention
The embodiment of the application aims to provide dentin-sensitivity-resistant toothpaste, a preparation method thereof and a dentin-sensitivity-resistant method.
In a first aspect, the present application provides an anti-dentinal sensitivity toothpaste comprising:
extruding a container, a first paste and a second paste;
The extrusion container comprises a container body;
the container comprises a container body and is characterized in that the container body comprises at least two subchambers along the extending direction of the container body, and the first paste and the second paste are respectively accommodated in one subchamber;
The first paste comprises bioactive glass and a first carrier acceptable by toothpaste, the first paste does not contain water, and the second paste comprises water and a second carrier acceptable by toothpaste.
According to the technical scheme, the novel instant mixing type dentin-sensitive toothpaste is provided, the novel instant mixing type dentin-sensitive toothpaste comprises bioactive glass, water and water, the first paste and the second paste are extruded from a toothpaste outlet in the using stage, the first paste and the second paste are not premixed, and are mixed through tooth brushing when acting on an oral cavity, at the moment, water in the second paste is used as an effective component and is used as an important accelerator of the bioactive glass, the bioactive glass can be rapidly activated to release the activity, the activity of the bioactive glass is improved, and the activated bioactive glass can target mineralized and plugged to expose dentin, so that the dentin-sensitive problem is fundamentally improved.
However, water is generally considered to be disadvantageous for bioactive glass in the art, so that bioactive glass anti-sensitization toothpastes commonly used in the market generally adopt an anhydrous formula, however, the anhydrous formula has the problems of poor taste, poor foaming (the bioactive glass is obviously reduced in activity if compounded with an anionic foaming agent in order to promote the foaming effect) and poor decontamination. The scheme of the application creatively discovers that water can be used as an accelerator of the bioactive glass, and the water can be used as an important accelerator of the bioactive glass in a 'mixing and using' mode through the arrangement of the chambers, so that the problem of a water-free formula is avoided.
Namely, the technical scheme creatively provides the instant mixing instant dentin-resistant toothpaste, effectively ensures the activity of bioactive glass in the toothpaste, enables the bioactive glass to interact and release the activity when the toothpaste is used, realizes truly effective dentin-resistant, and overcomes the technical prejudice in the field (water is unfavorable for bioactive glass).
In other embodiments of the present application, the amount of bioactive glass added in the first paste is 1% -10% by mass.
In other embodiments of the present application, the amount of water added in the second paste is 5% -25% by mass.
In other embodiments of the application, the bioactive glass comprises the following raw materials ：SiO240％～60％、CaO 20％～30％、P2O55％～12％、Na2O8％～13％、ZnO 0.5％～1.5％、SnO20.5％～1.5％、SrO 0.5％～1.5％ and F0.5% -1.5% by mass.
In other embodiments of the present application, the second paste further includes a soluble potassium salt, and the addition amount of the soluble potassium salt is 2% -15% by mass.
In other embodiments of the present application, the amount of soluble potassium salt added in the second paste is 5% -15% by mass.
In other embodiments of the application, the soluble potassium salt comprises at least one of potassium nitrate, potassium chloride, or potassium fluoride.
In other embodiments of the present application, the first paste further comprises a whitening and stain removing component;
Optionally, the whitening and stain removing component comprises peroxide;
Optionally, the peroxide is added into the first paste in an amount of 2% -10% by mass percent, and the hydrogen peroxide content is lower than 2% by mass percent;
optionally, the peroxide comprises at least one of hydrogen peroxide or a complex of hydrogen peroxide;
optionally, the hydrogen peroxide complex comprises at least one of a polyvinylpyrrolidone-hydrogen peroxide complex or carbamide peroxide.
In other embodiments of the present application, the second paste further comprises a low-valence metal salt;
optionally, the low-valence metal salt comprises a stannous salt;
Optionally, the stannous salt comprises at least one of stannous chloride or stannous fluoride;
Optionally, the addition amount of the low-valence metal salt in the second paste is 0.01% -0.45% by mass.
In other embodiments of the present application, the second paste further comprises an alkaline salt;
Optionally, in the second paste, the addition amount of the alkaline salt is 0.6-8% by mass percent;
Optionally, the alkaline salt comprises at least one of a carbonate or bicarbonate;
Optionally, the carbonate comprises at least one of sodium carbonate or potassium carbonate and the bicarbonate comprises at least one of sodium bicarbonate, potassium bicarbonate, magnesium bicarbonate or calcium bicarbonate.
In other embodiments of the application, the carbonate and the bicarbonate are included in a second paste;
In the second paste, the adding amount of carbonate is 0.1% -3.0%, the adding amount of bicarbonate is 0.5% -5% or
The second paste comprises the carbonate, wherein the adding amount of the carbonate in the second paste is 0.1-8.0% by mass percent, or
The second paste comprises the bicarbonate, wherein the adding amount of the bicarbonate in the second paste is 0.5-8.0% by mass percent.
In other embodiments of the present application, the second paste further comprises an anionic foaming agent;
Optionally, in the second paste, the addition amount of the anionic foaming agent is 2% -5% by mass;
optionally, the anionic foaming agent comprises at least one of sodium lauryl sulfate, sodium lauroyl sarcosinate or sodium methyl cocoyl taurate.
In other embodiments of the present application, the second paste further comprises betaines;
Optionally, in the second paste, the addition amount of betaine is 0.2% -5.0% by mass;
Optionally, the betaine comprises at least one of trimethylglycine, trialkylammonium inner salt, tetramethylammonium hydroxide or tetramethylammonium hydroxide.
In other embodiments of the present application, the first paste comprises carboxymethyl chitosan;
Optionally, the addition amount of carboxymethyl chitosan in the first paste is 0.1% -2.0% by mass.
In other embodiments of the present application, the first paste and the second paste further comprise a soluble zinc salt;
optionally, the addition amount of the soluble zinc salt in the first paste or the second paste is 0.12-0.38% by mass percent;
optionally, the soluble zinc salt comprises at least one of zinc citrate, zinc chloride or zinc fluoride.
In other embodiments of the present application, the first carrier comprises a humectant, a thickener, a friction agent, an emulsifier;
optionally, the first paste comprises 61-85% of humectant, 4.3-11% of thickener, 5-10% of friction agent, 1-8% of emulsifier, 0.12-0.38% of soluble zinc salt;
optionally, the humectant comprises at least one of propylene glycol, polyethylene glycols or glycerin;
optionally, the thickener comprises at least one of thickening silica or polyvinylpyrrolidone;
optionally, the friction agent comprises at least one of calcium pyrophosphate or friction silica;
optionally, the emulsifier comprises PEG-60 hydrogenated castor oil.
In other embodiments of the application, the second carrier comprises a humectant, a thickener, an appearance modifying agent, a friction agent, and optionally, a soluble zinc salt;
optionally, the humectant comprises at least one of glycerol, sorbitol, glycerol, polyethylene glycols or propylene glycol;
Optionally, the thickener comprises at least one of xanthan gum, carbomer, carrageenan, cellulose gum, hydroxyethyl cellulose, thickening silica or polyvinylpyrrolidone;
optionally, the appearance improver comprises titanium dioxide;
optionally, the friction agent comprises at least one of friction silica, dibasic calcium phosphate, calcium carbonate or tribasic calcium phosphate.
Optionally, the soluble zinc salt comprises at least one of zinc citrate, zinc chloride or zinc fluoride.
In other embodiments of the present application, the second paste comprises, in mass percent:
5% -25% of water, 2% -15% of soluble potassium salt, 35% -60% of humectant, 4.5% -12.5% of thickener, 0.2% -0.8% of appearance modifier, 5% -15% of friction agent and 0.12% -0.38% of soluble zinc salt;
In other embodiments of the present application, the extrusion container further comprises a cover plate, a driven extrusion structure, and a baffle plate;
the partition board is arranged in the cavity and is used for dividing the cavity into at least two subchambers along the extending direction of the container body, and the subchambers are communicated with the outlet of the container body;
the cover plate is detachably connected with the tail part of the container body through a connecting structure and is sealed;
The transmission extrusion structure is arranged in the container body and is movably connected with the cover plate, and the transmission extrusion structure is used for extruding the first paste and the second paste in the cavity from the outlet.
In other embodiments of the application, the transmission extrusion structure comprises a transmission member and a piston, wherein one end of the transmission member is movably connected with the cover plate, the transmission member is arranged in the cavity along the extending direction of the container body, the piston is in transmission connection with the transmission member, and the transmission member drives the piston to advance or retreat along the extending direction of the axis of the transmission member so as to extrude the first paste and the second paste.
In other embodiments of the present application, an anti-dentinal sensitivity toothpaste comprises a base;
The base comprises a base body;
The driving part is arranged in the base body;
The device comprises a base body, a driving structure, a butting part, a driving part and a first paste and second paste extruding structure, wherein the driving structure is arranged in the base body and is connected with the driving part;
the control module is arranged in the base body and is electrically connected with the driving part;
The power supply module is arranged in the base body and is respectively electrically connected with the control module and the driving part.
In other embodiments of the application, the transmission structure comprises a bracket and a transmission member, wherein the transmission member is arranged on the bracket, the output end of the driving member penetrates through the bracket, the output end of the driving member is connected with the transmission member, and the butting member is arranged at one end of the transmission member away from the output end of the driving member.
In a second aspect, the present application provides a method of preparing an anti-dentinal sensitivity toothpaste,
Extruding a container, a first paste and a second paste;
the squeeze container includes a container body;
at least two subchambers are arranged along the extending direction of the container body, and the first paste and the second paste are respectively accommodated in one subchamber;
The first paste comprises bioactive glass and a first carrier acceptable by toothpaste, and the first paste does not contain water;
the preparation method comprises the following steps:
the first paste is injected into one subchamber and the second paste is injected into the other subchamber.
In other embodiments of the present application, the amount of soluble potassium salt added in the second paste is 2% -15% by mass.
In a fourth aspect, the present application provides a method of combating dentinal sensitivity,
An anti-dentinal-sensitivity toothpaste is provided, the anti-dentinal-sensitivity toothpaste comprising:
extruding a container, a first paste and a second paste;
the squeeze container includes a container body;
at least two subchambers are arranged along the extending direction of the container body, and the first paste and the second paste are respectively accommodated in one subchamber;
The first paste comprises bioactive glass and a first carrier acceptable by toothpaste, and the first paste does not contain water;
the method comprises the following steps:
the first paste and the second paste are applied to the oral care implement as the first paste and the second paste are extruded, and the oral cavity is cleaned with the oral care implement.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the embodiments will be briefly described below, it being understood that the following drawings only illustrate some embodiments of the present application and therefore should not be considered as limiting the scope, and other related drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of the structure of an anti-dentinal sensitivity toothpaste according to an embodiment of the application;
FIG. 2 is a schematic view of the structure of an extrusion container according to an embodiment of the present application;
FIG. 3 is a schematic view of a base according to an embodiment of the present application;
FIG. 4 is a schematic view of a base according to another embodiment of the present application;
FIG. 5 shows a surface profile of Niu Yabiao after acid etching corresponding to example 1;
FIG. 6 shows a surface profile of Niu Yabiao after acid etching corresponding to example 3;
FIG. 7 shows a surface profile of Niu Yabiao after acid etching corresponding to example 5;
FIG. 8 shows a surface profile of Niu Yabiao after acid etching corresponding to comparative example 1;
FIG. 9 shows a surface profile of Niu Yabiao after acid etching corresponding to comparative example 2;
FIG. 10 shows a graph of bovine tooth surface morphology at 1k x electron microscope after the plugging experiment corresponding to example 1;
FIG. 11 shows a graph of bovine tooth surface morphology at 1k x electron microscope after the plugging experiment corresponding to example 3;
FIG. 12 shows a graph of bovine tooth surface morphology at 1k x electron microscope after the plugging experiment corresponding to example 5;
FIG. 13 shows a graph of bovine tooth surface morphology under a1 k-time electron microscope after a plugging experiment corresponding to comparative example 1;
FIG. 14 shows a graph of bovine tooth surface morphology under a1 k-time electron microscope after a plugging experiment corresponding to comparative example 2;
FIG. 15 shows the corresponding post-etch Niu Yabiao surface profile of example 1;
FIG. 16 shows the corresponding post-etch Niu Yabiao surface profile of example 2;
FIG. 17 shows a graph of bovine tooth surface morphology at 1k x electron microscope after the plugging experiment corresponding to example 1;
FIG. 18 shows a graph of bovine tooth surface morphology at 1k x electron microscope after the plugging experiments corresponding to example 2;
fig. 19 shows the mechanism of bioactive glass induced hydroxyapatite production.
The figures show 1-dentinally resistant toothpaste, 10-squeeze container, 100-container body, 200-cover plate, 130-partition, 110-chamber, 120-outlet, 111-subchamber, 300-connection, 410-drive, 420-piston, 11-base, 12-base body, 13-drive, 14-drive, 15-docking, 16-extension, 141-bracket, 142-drive, 800-cap, 1500-snap assembly.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present application more apparent, the technical solutions in the embodiments of the present application will be clearly and completely described below, and it is apparent that the described embodiments are some embodiments of the present application, but not all embodiments.
Thus, the following detailed description of the embodiments of the application is not intended to limit the scope of the application, as claimed, but is merely representative of selected embodiments of the application. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
Some embodiments of the present application provide an anti-dentinal sensitivity toothpaste comprising:
extruding a container, a first paste and a second paste;
The extrusion container comprises a container body;
The container comprises at least two subchambers along the extending direction of the container body, wherein the first paste and the second paste are respectively accommodated in one subchamber, the first paste comprises bioactive glass and a first carrier acceptable by toothpaste, the first paste does not contain water, and the second paste comprises water and a second carrier acceptable by toothpaste.
According to the technical scheme, the novel instant mixing type dentin-sensitive toothpaste is provided, the novel instant mixing type dentin-sensitive toothpaste comprises bioactive glass, water and water, the first paste and the second paste are extruded from a toothpaste outlet in the using stage, the first paste and the second paste are not premixed, and are mixed through tooth brushing when acting on an oral cavity, at the moment, water in the second paste is used as an effective component and is used as an important accelerator of the bioactive glass, the bioactive glass can be rapidly activated to release the activity, the activity of the bioactive glass is improved, and the activated bioactive glass can target mineralized and plugged to expose dentin, so that the dentin-sensitive problem is fundamentally improved.
Referring to fig. 1-4, some embodiments of the present application provide an anti-dentinal sensitivity toothpaste 1 comprising:
extrusion vessel 10, a first paste (not shown), a second paste (not shown);
extrusion container 10 includes container body 100, cover 200, driven extrusion structure and baffle 130;
The container body 100 is provided with a chamber 110, the container body 100 is provided with an outlet 120, the outlet 120 is communicated with the chamber 110, a baffle 130 is arranged in the chamber 110, the baffle 130 is used for dividing the chamber 110 into at least two subchambers 111 along the extending direction of the container body 100, the subchambers 111 are communicated with the outlet 120, and the first paste and the second paste are respectively accommodated in one subchamber 111;
The cover plate 200 is detachably connected with the tail of the container body 100 through the connecting structure 300 to seal;
the transmission extrusion structure is arranged in the container body 100 and is movably connected with the cover plate 200, and the transmission extrusion structure is used for extruding the first paste and the second paste in the cavity 110 from the outlet 120;
The first paste comprises bioactive glass and a first carrier acceptable by toothpaste, the first paste does not contain water, and the second paste comprises water and a second carrier acceptable by toothpaste.
In the technical scheme, the first paste comprises bioactive glass, the first paste does not contain water, and the second paste comprises soluble potassium salt, and the second paste contains water.
According to the technical scheme, the novel instant mixing type dentin-sensitive toothpaste is provided, the novel instant mixing type dentin-sensitive toothpaste comprises bioactive glass, the second paste comprises water, the first paste and the second paste are extruded from a toothpaste outlet through a transmission extrusion structure in the using stage, the first paste and the second paste are not mixed, and are mixed through tooth brushing when acting on an oral cavity, at the moment, water in the second paste is used as an effective component and is used as an important promoter of the bioactive glass, the bioactive glass can be rapidly activated to release the activity, the activity of the bioactive glass is promoted, and the activated bioactive glass can target mineralized and plugged exposed dentin, so that the dentin-sensitive problem is fundamentally improved.
Further, the bioactive glass can be quickly subjected to ion exchange with human body liquid, and a hydroxyapatite layer similar to bone tissue composition is formed on the surface through a series of reactions, so that stable chemical bonding is formed with bone tissue or soft tissue of a human body, bone tissue regeneration is induced, and the mechanism of the bioactive glass for inducing generation of hydroxyapatite is shown in figure 19:
this determines that the bioactive glass should be anhydrous in the presence of the formulation to remain active.
In the prior art, bioactive glass is applied to an anhydrous formula in the prior art, however, toothpaste with the anhydrous formula has poor taste such as air bubble property and the like, so that the detergency of the toothpaste is poor.
However, through extensive research in the present application, it was found that when the first paste comprises bioactive glass and the first paste is free of water, the second paste comprises soluble potassium salt and the second paste is aqueous, i.e., the bioactive glass is separated from water during the storage period, the activity of the bioactive glass can be preserved, but water can promote the activity of the bioactive glass during the use period, i.e., the "ready-to-mix" solution of the present application, the "water" in the second paste becomes an effective component at this time, can act as an important promoter of the bioactive glass to promote the efficacy exertion of the bioactive glass, and can rapidly activate the bioactive glass to release the activity during the "ready-to-mix" solution.
Furthermore, the scheme of the application of mixing and using simultaneously avoids the problems of difficult foaming, poor taste and poor detergency of the single-tube anhydrous bioactive glass.
Further, in some embodiments of the present application, the amount of bioactive glass added in the first paste is 1% -10% by mass.
Further, in some embodiments of the present application, the amount of water added in the second paste is 5% -25% by mass.
According to the technical scheme, the addition amount of the bioactive glass and the water is within the range, the activity release of the bioactive glass can be further promoted in the stage of 'mixing and using at once', 1g of the minimum addition amount of the bioactive glass is measured, and the water containing more than 5% of deionized water in the water-containing formula can activate the activity within 2min to complete the release.
Further alternatively, and by way of example, in some embodiments of the application, the bioactive glass is added to the first paste in an amount of 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10% or a range between any two of the foregoing values, in mass percent.
Further alternatively, illustratively, in some embodiments of the present application, the amount of water added to the second paste is 5%, 8%, 9%, 10%, 11%, 12%, 15%, 18%, 20%, 21%, 22%, 23%, 25% or a range between any two of the foregoing values, in mass percent.
Further, in some embodiments of the present application, the bioactive glass comprises following raw materials ：SiO240％～60％、CaO 20％～30％、P2O55％～12％、Na2O8％～13％、ZnO 0.5％～1.5％、SnO20.5％～1.5％、SrO 0.5％～1.5％ and 0.5% -1.5% by mass.
The bioactive glass contains trace fluorine, strontium, zinc and other elements, and is favorable to resisting dentin sensitivity. In the using stage, the first paste, the second paste, the artificial saliva and the water-containing component in the second paste can quickly generate a large amount of hydroxyapatite, and the zinc, tin, strontium and fluorine elements are dissolved out, so that the oral cavity and teeth are beneficial to health.
Further, in some embodiments of the present application, the bioactive glass may be prepared by referring to the preparation method in chinese patent 201811369263.4.
Further, in some embodiments of the present application, the second paste further includes a soluble potassium salt, and the addition amount of the soluble potassium salt in the second paste is 2% -15% by mass.
In the technical scheme, the second paste comprises the soluble potassium salt, and the soluble potassium salt can reduce the sensitivity of dentin and pulpal nerve endings, so that dentin sensitivity is relieved, and the effect of treating the symptoms is realized. Further, the first paste comprises bioactive glass, the bioactive glass can be quickly subjected to ion exchange with human body liquid in the human body liquid, and a hydroxyl phosphorite layer similar to bone tissue composition is formed on the surface through a series of reactions, so that stable chemical bonding is formed with bone tissue or soft tissue of the human body, bone tissue regeneration is induced, the bioactive glass acts on teeth, a stable inorganic blocking layer can be formed under the dentin targeting effect, dentin sensitivity is fundamentally realized, and the effect of treating root cause is realized. The toothpaste for preventing dentin sensitivity can realize the effects of treating both symptoms and root causes, and truly realizes dentin sensitivity resistance.
Further, in some embodiments of the present application, the amount of soluble potassium salt added in the second paste is 5% -15% by mass.
In the above-described technical means, by setting the addition amount of the soluble potassium salt within the above-described range, the sensitivity of dentin and pulp nerve endings can be effectively reduced, and dentin sensitivity can be relieved.
Further, when the addition amount of the soluble potassium salt is 5% -15%, the sensitivity of dentin and pulp nerve endings can be greatly enhanced and reduced, so that the dentin sensitivity effect is relieved.
The potassium-containing single desensitizing toothpaste sold at present has the concentration of potassium not higher than 5% and limited effect on relieving dentin sensitivity. This is because such conventional single tube toothpastes no longer increase the potassium content. If the salt content of the formula system is increased continuously, the colloid stability in the paste is destroyed by high salt compared with a low-content potassium system, so that the shelf life of the product is greatly reduced, and on the other hand, the addition of high-concentration acid radicals can increase the oxidation of the acid radicals due to high temperature or reduced pH of the paste in the storage process of the product, increase the oxidation of the acid radicals and increase the reactions of essence or other active ingredients in the formula system, so that the stability of the paste is destroyed and the taste or appearance is changed.
According to the technical scheme, the second paste comprises the soluble potassium salt, the second paste contains water, namely the soluble potassium salt is arranged in the water-containing formula, so that the concentration of the potassium salt in a system can be improved, the dentin sensitivity relieving effect is improved, and meanwhile, the stability of the paste is not influenced. But also achieves the effect of promoting the release of the bioactive glass in the first paste in the phase of 'mixing and using at the same time'.
Illustratively, in some embodiments of the application, the amount of soluble potassium salt added to the second paste is 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15% or a range between any two of the foregoing values, in mass percent.
Further, in some embodiments of the application, the soluble potassium salt comprises at least one of potassium nitrate, potassium chloride, or potassium fluoride.
Illustratively, in some embodiments of the application, the soluble potassium salt is selected from any of potassium nitrate, potassium chloride, or potassium fluoride, or in some embodiments of the application, the soluble potassium salt is selected from a mixture of potassium nitrate and potassium chloride, and the individual materials in the mixture may be mixed in any ratio.
Further, in the above-described technical solution, the first paste and the second paste in the chamber 110 are sealed by connecting the cover plate 200 to the tail of the extrusion container 10. Through set up the transmission extrusion structure that is used for extruding first lotion, second lotion in container body 100, rely on the connection between apron 200 and the transmission extrusion structure, can make transmission extrusion structure in the in-process of extruding the material from the export, apron 200 plays the effect of location and support transmission extrusion structure, realizes that transmission extrusion structure is more stable, extrudes first lotion, second lotion from the export with high efficiency. The sealing effect of the cover plate 200 can improve the problem that the first paste and the second paste leak from the cavity 110 when the first paste and the second paste are extruded by the transmission extrusion structure, reduce the risk of faults of the extrusion container 10, and improve the working efficiency of the extrusion container 10 for extruding the first paste and the second paste.
Further, in the above technical solution, the first paste and the second paste are extruded from the outlet of the chamber 110 to form a complete and shaped paste (the first paste and the second paste are contacted and connected together, but can be clearly distinguished), and in the using stage, the user can be ensured to simultaneously act the first paste and the second paste in the oral cavity, and the first paste and the second paste are more favorably mixed uniformly in the oral cavity, and the active ingredients are more favorably released in the oral cavity, so that the effect of dentin sensitivity resistance is more favorably improved.
Furthermore, in the technical scheme, the first paste and the second paste are mixed and used at once, so that the paste is milder, more suitable for an oral environment and more beneficial to protecting oral mucosa. Under one scene, only a single tube ordinary anhydrous anti-allergic toothpaste containing bioactive glass is adopted, and potassium nitrate (such as powder or solution) is added into the ordinary anhydrous anti-allergic toothpaste in the using stage, so that the oral mucosa is more irritated, the oral mucosa is not easy to clean or is extremely bad in taste, the oral mucosa is difficult to use, the use is very troublesome, the practical application value is greatly reduced, and under the other scene, two active substances (such as bioactive glass and potassium nitrate powder or potassium nitrate solution) are directly adopted to act on the oral cavity, the irritation is very large, the oral mucosa is extremely bad in taste, the use is difficult to clean, the use is very troublesome, and the practical application value is greatly reduced.
Further alternatively, in some embodiments of the present application, the number of the sub-chambers 111 is two, and the first paste and the second paste are each contained in one sub-chamber 111.
In other alternative embodiments of the present application, the above-mentioned sub-chambers 111 may be selectively configured to be three, four, five, etc., but the first paste and the second paste are always located in two independent sub-chambers 111, the remaining sub-chambers 111 may be configured according to actual needs, and other paste may be illustratively contained in the other sub-chambers 111, or other non-paste materials (such as water, etc.), or may be configured to be blank (such as may be left blank for personalized use by a user, etc.).
Further, in some embodiments of the application, the second paste includes an anionic foaming agent.
Further, in some embodiments of the application, the anionic foaming agent comprises at least one of sodium lauryl sulfate, sodium lauroyl sarcosinate or sodium methyl cocoyl taurate.
The anionic foaming agent is very easy to combine with calcium ions released by bioactive glass when meeting water to generate a soap scum-like component which is difficult to dissolve in water, so that the active content of the bioactive glass in the paste during storage is reduced, in addition, the consumption of the anionic foaming agent can also lead to the reduction of the foam amount during tooth brushing, and the detergency in the oral cavity is reduced.
In the technical scheme, the anionic foaming agent is arranged in the second paste and is isolated from the bioactive glass in the first paste, so that the loss of the activity of the anionic foaming agent on the bioactive glass is avoided. Meanwhile, the second paste in the water-containing formula adopts an anionic foaming agent, so that the overall foaming effect of the toothpaste can be effectively improved, the detergency is improved, the using taste is improved, and the problems of poor taste, poor foaming and poor decontamination of the anhydrous bioactive glass toothpaste in the prior art are effectively solved.
Further, in some embodiments of the present application, the amount of the anionic foaming agent added in the second paste is 2% -5% by mass.
Illustratively, the amount of anionic foaming agent added in the second paste is 2%, 2.1%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5% or a range between any two of the foregoing values in mass percent.
Further, in some embodiments of the application, the second paste further comprises betaines.
The betaine has the functions of moisturizing and relieving the gum tissues of mucous membranes, can also show excellent antibacterial property, and can effectively inhibit gram-positive bacteria, gram-negative bacteria, saccharomycetes and mould. Can inhibit dental plaque and care gum.
Further, in some embodiments of the present application, the amount of betaine added in the second paste is 0.2% -5.0% by mass.
Within the above content range, the effect of inhibiting dental plaque and caring gums can be effectively exerted.
Illustratively, in some embodiments of the present application, the betaine is added to the second paste in an amount of 0.2%, 0.3%, 0.5%, 0.8%, 1%, 1.2%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 4.8%, 5.0% by mass or a range between any two of the foregoing values.
Further, in some embodiments of the present application, betaines include at least one of trimethylglycine, trialkylammonium inner salts, tetramethylammonium hydroxide, or tetramethylammonium hydroxide.
Illustratively, in some embodiments of the application, the betaines are selected from any of trimethylglycine, trialkylammonium inner salts, tetramethylammonium hydroxide, or tetramethylammonium hydroxide. Or betaine is selected from the mixture of trimethylglycine and trialkylammonium inner salt, and the substances in the mixture can be mixed in any proportion.
Further, in some embodiments of the present application, the first paste further comprises carboxymethyl chitosan.
In the technical scheme, the retention of the functional components can be improved, and besides, the carboxymethyl chitosan and betaine are rich in specific ammonium ions, so that the carboxymethyl chitosan has excellent antibacterial property and can effectively inhibit gram-positive bacteria, gram-negative bacteria, saccharomycetes and mildew. The synergistic effect of the two can inhibit dental plaque and care gums.
Further, in some embodiments of the present application, the amount of carboxymethyl chitosan added in the first paste is 0.1% -2.0% by mass. Within the above content range, the effect of inhibiting dental plaque and caring gums can be effectively exerted.
Illustratively, in some embodiments of the present application, the carboxymethyl chitosan is added to the first paste in an amount of 0.1%, 0.2%, 0.5%, 0.8%, 1%, 1.2%, 1.3%, 1.5%, 1.8%, 2.0% or a range between any two of the foregoing values, in mass percent.
Further, in some embodiments of the present application, the first paste includes a whitening and stain removing component.
According to the technical scheme, the whitening and stain removing component is added into the first paste, so that tooth stains of the organic isolation layer can be removed, and conditions are created for forming a stable inorganic blocking layer under the targeting effect of bioactive glass of the active component.
Further, in some embodiments of the present application, the whitening and stain removing component comprises a peroxide.
Further, in some embodiments of the present application, the peroxide is added to the first paste in an amount of 2% -10% by mass, and the hydrogen peroxide content is lower than 2% by mass.
Further, in some embodiments of the application, the peroxide comprises at least one of hydrogen peroxide or a complex of hydrogen peroxide.
Further, in some embodiments of the application, the hydrogen peroxide complex comprises at least one of a polyvinylpyrrolidone-hydrogen peroxide complex or carbamide peroxide.
Further, in some embodiments of the present application, the second paste further comprises a low valence metal salt.
The peroxide can generate Fenton-like reaction after contacting with the low-valence metal salt to generate free hydroxyl, and the free hydroxyl acts on teeth, so that the whitening effect can be enhanced. The peroxide and the low-valence metal salt are subjected to Fenton-like reaction in the stage of 'mixing just before use', free hydroxyl is generated, the free hydroxyl acts on teeth, tooth stains of an organic matter isolation layer are removed, the subsequent bioactive glass targeted blocking effect is improved, and the dentin sensitivity resisting effect is improved.
Further, in some embodiments of the application, the low-valence metal salt comprises a stannous salt.
Further, in some embodiments of the application, the stannous salt comprises at least one of stannous chloride or stannous fluoride.
Illustratively, taking stannous salts as an example, the following Fenton-like reaction can occur when the stannous salts are contacted with the peroxide:
From the reaction, the stannous salt and the peroxide are contacted to generate Fenton-like reaction, so that free hydroxyl can be generated, and the free hydroxyl acts on teeth to effectively remove tooth stains of an organic matter isolation layer, improve the subsequent bioactive glass targeted blocking effect and improve the dentin sensitivity resisting effect.
Further, in some embodiments of the present application, the amount of the low-valence metal salt added in the second paste is 0.01% -0.45% by mass.
According to the technical scheme, the addition amount of the low-valence metal salt in the second paste is 0.01% -0.45%, and the low-valence metal salt and the peroxide in the first paste can further realize synergistic effect when being mixed and used, so that the whitening effect is enhanced.
Illustratively, in some embodiments of the application, the low-valence metal salt is added in an amount of 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.1%, 0.2%, 0.3%, 0.35%, 0.4%, 0.41%, 0.42%, 0.43%, 0.44%, 0.45%, or a range between any two of the foregoing.
Further, in some embodiments of the present application, the second paste further comprises an alkaline salt.
The alkaline salt is favorable for removing bacteria and organic stains on the damaged tooth parts by active oxygen, and is favorable for creating conditions for forming a stable inorganic blocking layer by the targeting effect of bioactive glass serving as an active ingredient.
Still alternatively, in some embodiments of the present application, the alkaline salt comprises at least one of a carbonate or bicarbonate salt.
The carbonate or bicarbonate is beneficial to removing bacteria and organic stains on the damaged tooth parts by active oxygen, and is beneficial to creating conditions for the active ingredient bioactive glass to form a stable inorganic blocking layer.
Further, the combination of the alkaline salts and the peroxide is beneficial to removing bacteria and organic stains on the damaged teeth by the active oxygen, and the efficient active oxygen double-component formula removes the stains on the organic isolation layer, thereby creating conditions for forming a stable inorganic blocking layer by targeting.
Illustratively, the reaction of the above basic salts with peroxides is as follows:
The reaction formula can be seen that the peroxide is reacted with sodium bicarbonate to generate peroxy radicals, so that the tooth stain removing effect of the organic isolation layer is enhanced compared with that of single hydrogen peroxide.
Further, in some embodiments of the present application, the carbonate salt comprises at least one of sodium carbonate or potassium carbonate, and the bicarbonate salt comprises at least one of sodium bicarbonate, potassium bicarbonate, magnesium bicarbonate, or calcium bicarbonate.
Illustratively, in some embodiments of the application, the carbonate salt is selected from either sodium carbonate or potassium carbonate, or in some embodiments of the application, the carbonate salt is selected from a mixture of sodium carbonate and potassium carbonate, and the individual materials in the mixture may be mixed in any ratio.
Illustratively, in some embodiments of the application, the bicarbonate is selected from any of sodium bicarbonate, potassium bicarbonate, magnesium bicarbonate, or calcium bicarbonate. Or in some embodiments of the application, the bicarbonate is selected from the group consisting of sodium bicarbonate, potassium bicarbonate, magnesium bicarbonate and calcium bicarbonate, or in some embodiments of the application, the bicarbonate is selected from the group consisting of sodium bicarbonate and potassium bicarbonate, or in some embodiments of the application, the bicarbonate is selected from the group consisting of magnesium bicarbonate and calcium bicarbonate, or in some embodiments of the application, the bicarbonate is selected from the group consisting of sodium bicarbonate, potassium bicarbonate and magnesium bicarbonate, and the raw materials in the mixture can be mixed in any ratio.
Further, in some embodiments of the present application, the amount of the alkaline salt added in the second paste is 0.6% -3.5% by mass.
In the technical scheme, the addition amount of the alkaline salt in the second paste is 0.6% -3.5%, and the whitening effect can be further improved by further synergistic interaction with the peroxide.
Illustratively, in some embodiments of the application, the amount of alkaline salt added is 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.5%, 1.6%, 1.8%, 2%, 2.2%, 2.5%, 2.8%, 3%, 3.1%, 3.2%, 3.3%, 3.4%, 3.5% or a range between any two of the foregoing.
Further, in some embodiments of the present application, the adding amount of carbonate in the second paste is 0.1% -8.0% by mass.
According to the technical scheme, the adding amount of the carbonate in the second paste is 0.1% -8.0%, and the second paste can be further synergistic with other raw materials such as the peroxide, so that the whitening effect is further improved.
Further, in some embodiments of the application, the carbonate and bicarbonate are included in the second paste;
The adding amount of the carbonate in the second paste is 0.1-3.0% by mass percent, and the adding amount of the bicarbonate is 0.5-5% by mass percent.
In the technical scheme, in the second paste, the carbonate and the bicarbonate can be further synergistic with other raw materials such as the peroxide, so that the whitening effect is further improved.
Illustratively, in some embodiments of the present application, the carbonate is added to the second paste in a mass percent amount that is 0.1%、0.2%、0.3%、0.4%、0.5%、0.6%、0.7%、0.8%、0.9%、1%、1.1%、1.2%、1.3%、1.4%、1.5%、1.6%、1.7%、1.8%、1.9%、2%、2.1%、2.2%、2.3%、2.4%、2.5%、2.6%、2.7%、2.8%、2.9%、3.0% or a range between any two of the foregoing values. Illustratively, in some embodiments of the application, the bicarbonate is added to the second paste in an amount of 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.5%, 1.8%, 2%, 2.5%, 2.8%, 3%, 3.5%, 3.8%, 4%, 4.5%, 4.8%, 5% or a range between any two of the foregoing values, by mass percent.
Further, in some embodiments of the present application, the second paste includes the carbonate, and the adding amount of the carbonate in the second paste is 0.1% -8.0% by mass.
Further, in some embodiments of the present application, the second paste includes the bicarbonate, and the adding amount of the bicarbonate in the second paste is 0.5% -8.0% by mass.
Illustratively, in some embodiments of the application, the bicarbonate is added to the second paste in an amount of 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.5%, 1.8%, 2%, 2.5%, 2.8%, 3%, 3.5%, 3.8%, 4%, 4.5%, 4.8%, 5% or a range between any two of the foregoing values, by mass percent.
Further, in some embodiments of the application, the first carrier comprises a humectant, a thickener, a friction agent, an emulsifier.
Further, in some embodiments of the application, the first paste comprises, by mass, 1% -10% of bioactive glass, 61% -85% of a humectant, 4.3% -11% of a thickener, 5% -10% of an abrasive, 1% -8% of an emulsifier, and 0.12% -0.38% of a soluble zinc salt.
Illustratively, in some embodiments of the application, the first paste comprises, in mass percent, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10% or a bioactive glass having a content in the range between any two of the foregoing, 61%, 62%, 65%, 68%, 70%, 72%, 75%, 78%, 80%, 82%, 83%, 84%, 85% or a humectant having a content in the range between any two of the foregoing, 4.3%, 4.5%, 4.8%, 5%, 5.3%, 6%, 6.3%, 6.5%, 7%, 7.5%, 8%, 8.5%, 9%, 10%, 10.5%, 11% or a thickener having a content in the range between any two of the foregoing, a friction agent having a content in the range between any two of the foregoing, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8% or ,0.12%、0.13%、0.15%、0.18%、0.2%、0.22%、0.25%、0.28%、0.30%、0.31%、0.32%、0.33%、0.34%、0.35%、0.36%、0.37%、0.38%% or a zinc salt having a content in the range between any two of the foregoing, optionally.
Further, in some embodiments of the present application, the humectant comprises at least one of propylene glycol, polyethylene glycols, or glycerin.
Further, in some embodiments of the application, the thickener comprises at least one of a thickening silica or polyvinylpyrrolidone.
Further, in some embodiments of the application, the abrasive comprises at least one of calcium pyrophosphate or abrasive silica.
Further, in some embodiments of the application, the emulsifier comprises PEG-60 hydrogenated castor oil.
Further, in some embodiments of the application, the second carrier comprises a humectant, a thickener, an appearance improving agent, a friction agent.
Further, in some embodiments of the present application, the humectant comprises at least one of glycerin, sorbitol, glycerol, polyethylene glycols or propylene glycol.
Further, in some embodiments of the present application, the thickener comprises at least one of xanthan gum, cellulose gum, hydroxyethyl cellulose, thickening silica, or polyvinylpyrrolidone.
Further, in some embodiments of the application, the appearance improver comprises titanium dioxide.
Further, in some embodiments of the application, the friction agent comprises at least one of a friction silica or a calcium pyrophosphate.
Further, in some embodiments of the present application, the second paste comprises, in mass percent:
5% -25% of water, 2% -15% of soluble potassium salt, 35% -60% of humectant, 4.5% -12.5% of thickener, 0.2% -0.8% of appearance modifier, 5% -15% of friction agent, 0.12% -0.38% of soluble zinc salt, and in some embodiments of the application, the second paste comprises, by mass percent:
A composition comprising a water-soluble salt in an amount of 5%, 6%, 8%, 10%, 12%, 13%, 15%, 18%, 20%, 21%, 22%, 23%, 24%, 25% or a range between any two of the foregoing, a soluble potassium salt in an amount of 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15% or a range between any two of the foregoing, a humectant in an amount of 35%, 36%, 37%, 38%, 40%, 45%, 50%, 55%, 60% or a range between any two of the foregoing, a thickener in an amount of 4.5%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12.5% or a range between any two of the foregoing, an appearance improver in an amount of 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8% or a range between any two of the foregoing, a soluble zinc salt in an amount of 5%, 6%, 8%, 10%, 11%, 12%, 13%, 14%, 15% or a range between any two of the foregoing, a zinc salt in an amount of any two of the foregoing, or a range between any two of the foregoing, a zinc salt in an amount of the foregoing, or a range between any two of the foregoing. Further alternatively, in some embodiments of the present application, both the first paste and the second paste may further include a sweetener, such as mannitol, sucralose, and a flavor.
Further alternatively, the first paste comprises, by mass, 0.08-0.2% of sucralose, 1-15% of mannitol and 0.8-1.4% of essence.
Further alternatively, the second paste comprises, by mass, 0.08-0.2% of trichlorogalactose and 0.8-1.4% of essence.
Further, in some embodiments of the present application, the transmission extrusion structure includes a transmission member and a piston, wherein one end of the transmission member is movably connected with the cover plate, the transmission member is disposed in the cavity along the extending direction of the container body, the piston is in transmission connection with the transmission member, and the transmission member drives the piston to advance or retreat along the extending direction of the axis of the transmission member, so as to extrude the first paste and the second paste.
Referring to fig. 2, in some embodiments of the present application, the transmission extrusion structure includes a transmission member 410 and a piston 420, wherein one end of the transmission member 410 is movably connected with the cover plate 200, the transmission member 410 is disposed in the chamber 110 along the extending direction of the container body 100, the piston 420 is in transmission connection with the transmission member 410, and the transmission member 410 drives the piston 420 to advance or retract along the extending direction of the axis of the transmission member 410, so as to extrude the material.
In this embodiment, the piston 420 is driven to advance or retract along the extending direction of the axis of the transmission member 410 by forward and reverse transmission of the transmission member 410 in the transmission extrusion structure, so as to realize automatic extrusion of the piston 420 to the material in the chamber 110.
Taking the structure of the extrusion container 10 shown in fig. 1-2 as an example, since one partition 130 is disposed in the container body 100, the cavity 110 of the container body 100 is divided into two separate sub-cavities 111, and each sub-cavity 111 is used for accommodating the first paste and the second paste. In order to realize automatic synchronous extrusion of toothpaste in the two subchambers 111 and achieve the purpose of mixing and using, the transmission extrusion structure in the embodiment comprises two transmission parts 410 and two pistons 420, wherein each subchamber 111 is respectively provided with one transmission part 410 and one piston 420, the two transmission parts 410 can synchronously rotate, and further the two pistons 420 are driven to synchronously advance or retreat, so that automatic synchronous extrusion of toothpaste with different components in the two subchambers 111 is finally realized.
In some embodiments of the present application, the transmission extrusion structure may be an electric push rod, where a piston 420 is disposed at an end of the electric push rod, and the piston 420 is pushed by the electric push rod to advance or retract, so as to realize automatic extrusion of the toothpaste.
Further, referring to FIGS. 3-4, in some embodiments of the present application, an anti-dentinal sensitivity toothpaste comprises a base 11;
the base 11 includes a base body 12;
A driving member 13 provided in the base body 12;
the device comprises a base body 12, a transmission structure 14, a butting part 15, a driving part 13, a driving part 14 and a first paste and second paste extrusion structure, wherein the transmission structure 14 is arranged in the base body 12 and is connected with the driving part 13;
the control module is arranged in the base body 12 and is electrically connected with the driving part 13;
the power supply module is arranged in the base body 12 and is respectively and electrically connected with the control module and the driving part 13.
Further, in some embodiments of the present application, the transmission structure 14 includes a bracket 141 and a transmission member 142, the transmission member 142 is disposed on the bracket 141, an output end of the driving part 13 penetrates the bracket 141, and the output end of the driving part 13 is connected with the transmission member 142, and the docking part 15 is disposed on an end of the transmission member 142 away from the output end of the driving part 13.
Referring to fig. 1 to 4, a switch is disposed on a container body 100, a socket member is disposed on the container body, the switch is electrically connected with the socket member, and the socket member is used for electrically connecting with a conductive member on a base mounted in cooperation with the extrusion container 10 to transmit an electrical signal.
In some embodiments of the present application, after the installation of the base and the extrusion container 10 is completed, the driving structure is in butt joint with the transmission extrusion structure in the extrusion container 10, after the user triggers the switch, the circuit between the extrusion container 10 and the base is turned on, the control module sends a control instruction to the driving structure according to the switch signal triggered by the user, the driving structure receives the instruction, drives the transmission extrusion structure to work, and drives the piston to advance through the rotation of the transmission member 410, so as to realize the automatic synchronous extrusion of the first paste and the second paste.
In some embodiments of the present application, the dentin-resistant toothpaste 1 further comprises a cap 800, and the cap 800 is connected to the container body 100.
In some embodiments of the present application, the base body 12 is provided with a fastening assembly 1500, and the base body 12 is detachably connected to the extrusion container through the fastening assembly 1500.
In some embodiments of the present application, the base body 12 is provided with an extension 16, the switch and the plug member are provided on the extension 16, and the switch is provided on the extension 16 at an end near the outlet of the extrusion container.
Some embodiments of the present application provide a method of preparing an anti-dentinal sensitivity toothpaste,
An anti-dentin sensitive toothpaste comprises an extrusion container, a first paste and a second paste;
The extrusion container comprises a container body;
the container comprises at least two subchambers along the extending direction of the container body, wherein the first paste and the second paste are respectively accommodated in one subchamber, the first paste comprises bioactive glass and a first carrier acceptable by toothpaste, and the first paste does not contain water;
the preparation method comprises the following steps:
the first paste is injected into one subchamber and the second paste is injected into the other subchamber.
In some embodiments of the present application, the amount of soluble potassium salt added in the second paste is 2% -15% by mass.
Some embodiments of the application provide a method of combating dentinal sensitivity,
An anti-dentinal-sensitivity toothpaste is provided, the anti-dentinal-sensitivity toothpaste comprising:
extruding a container, a first paste and a second paste;
The extrusion container comprises a container body;
the container comprises at least two subchambers along the extending direction of the container body, wherein the first paste and the second paste are respectively accommodated in one subchamber, the first paste comprises bioactive glass and a first carrier acceptable by toothpaste, and the first paste does not contain water;
the method comprises the following steps:
the first paste and the second paste in the cavity are applied to the oral care implement while being extruded from the outlet, and the oral cavity is cleaned with the oral care implement.
The features and properties of the present application are described in further detail below in connection with the following examples, in which each of the raw materials used is commercially available;
The formulations of the first paste or the second paste in each example or comparative example are selected from the following tables 1 to 10, and the first paste and the second paste may be prepared using a conventional process for preparing toothpaste in the art.
TABLE 1 Anhydrous formulations S1-1
TABLE 2 aqueous formulations S1-2
TABLE 3 Anhydrous formulations S2-1 (glass without bioactivity)
TABLE 4 Single Anhydrous tube D-1 (bioactive glass + Potassium nitrate)
Table 5 Anhydrous formulation S3-1 (without whitening efficacy ingredient)
Table 6 Water-containing formulation S3-2 (without whitening efficacy ingredient)
TABLE 7 Anhydrous formulation S4-1
Table 8 Anhydrous formulation S5-1
TABLE 9 aqueous formulation S4-2
Table 10 aqueous formulation S5-2
1. Appearance performance dispersibility and stability verification
Appearance performance dispersibility the paste composition prepared at present is extruded for 2g, 4 glass beads with the diameter of 0.5cm are added respectively, and after uniform dispersion is carried out for 1min by oscillating at 2000r/min under a vortex oscillator, the paste composition is poured into a surface dish for observation of paste dispersion condition.
And (3) adopting an accelerated aging test to examine the stability of the formula under the conditions different from long-term storage temperature and humidity, and primarily predicting the quality maintenance trend of the formula under the specified storage conditions. The acceleration test is performed under test conditions of a certain temperature and humidity (such as 40 ℃ plus or minus 2 ℃ and 75% RH plus or minus 5% RH). Stability data for 30 months of storage at room temperature relative to the corresponding product for three months using the 40 ℃ 2 ℃ and 75% RH 5% RH acceleration test according to ISO 11609 international standard are shown in table 11:
TABLE 11
As can be seen from the data in the above table, the two-component paste of each example has better dispersibility in water than a single tube, because the calcium cinnamyl sulfate precipitate layer formed in the single tube is doped or coated with colloid to form a colloid group with stronger toughness, so that the dispersibility is weakened, and finally, the active functional ingredients cannot be well released to the tooth surface. Besides the reason that the stability of a single tube is poor, the colloid of the thickener cannot be well stretched out due to the compounding of high-salt components, so that a three-dimensional net-packed structure is formed to maintain the lasting stability of the paste.
2. Active ion interferential verification
And (3) preparing and storing the numbered formula for one week, preparing mixed liquid, and calibrating and verifying the concentration of the soluble calcium ions respectively. Preparing slurry, namely weighing 3g of each formula, putting 6g (accurate to 0.01 g) of combined sample into a 25mL centrifugal test tube, dissolving with 9.6g of water, stirring at a high speed by vortex for 1min until the toothpaste is uniformly dispersed, centrifuging at 8000r/min in a high speed centrifuge for 1min, separating out supernatant, and measuring each group of data by an atomic absorption spectrometry as shown in Table 12:
Table 12
The above experiments show that the stability of the single tube provided in comparative example 2 and the release of calcium ions during later use of bioactive glass are both poor relative to the individual examples in the case of using a toothpaste that maintains a normal experience of anti-sensitization. The method is characterized in that in the process of preparing the single-tube toothpaste, under the condition that trace moisture of partial raw materials is brought in, calcium ions are released by bioactive glass when meeting water and lauryl sulfate anions which are hardly soluble in water are formed by sodium lauryl sulfate which is a foaming agent when meeting water, and lauryl sulfate calcium precipitation which is difficult to dissolve in water is formed in the stirring process, so that the foaming performance of the foaming agent and the emulsifying property of essence in a formula body are reduced, the stability of a formula system is deteriorated, oil is easily discharged, and meanwhile, precipitation formed by calcium ions is consumed, which is equivalent to the activity of bioactive glass which is released in advance, so that the concentration of the calcium ions is detected to be low.
In contrast, comparative example 1 does not contain bioactive glass, does not release calcium ions, has poor anti-sensitization effect, and cannot maintain normal anti-sensitization experience.
2. Verification of anti-sensitization Effect
Toothbrushing was performed using toothpastes of respective examples, comparative examples, respectively:
(1) The experimental bovine teeth were fresh bovine teeth, surface contaminants were removed, rinsed clean, and placed in deionized water containing 0.05% thymol, and placed in a4 ℃ refrigerator for use. In the experiment, fresh bovine teeth are taken and cut into 1cm x 2m cubic dental films by a low-speed cutting machine, and then the cubic dental films are ground by a grinding and polishing machine (600 # sand paper) to remove Niu Yaya enamel so as to expose dentin tubules. The prepared bovine tooth slices (approximately with the specification of 0.8cm x 1 mm) are subjected to acid etching for 3min by using a 6% citric acid solution, and then the acid etched bovine teeth are placed in purified water and cleaned in an ultrasonic cleaner for 3min, so that surface substances are removed. After 24 hours of drying at normal temperature, SEM was examined to determine dentinal tubule permeability.
1. And placing the dental film into the groove of the acrylic plate.
2. Respectively taking 0.4g of toothpaste onto the tooth film in the groove of the acrylic plate, and then taking 0.8g of water into the groove of the acrylic plate.
3. The acrylic plate was placed on an electronic balance, and immediately after 3 minutes of simulated brushing, the electric toothbrush (oral-B) was allowed to stand for 2 minutes, and the balance count was controlled to be displayed at about 150 g.
4. After each brushing, the plaque was removed and placed in artificial saliva at 37 ℃ with 20mL deionized water and rinsed for 30 seconds with shaking in a thermostatted shaker at 180 rpm.
5. Brushing 8 times per day (the tooth film is placed in the artificial saliva after each brushing) and brushing is performed for 3 days in a cumulative way, and the brushing is simulated for 14 days.
6. After the tooth brushing experiment was completed, the brush was cleaned by shaking for 2 minutes and dried. The bovine dentin sample was dried in an incubator at 25 ℃ for 24 hours, and was observed by a Scanning Electron Microscope (SEM) after drying.
The test results are shown in the attached drawings of the specification:
FIG. 5 shows a surface profile of Niu Yabiao after acid etching corresponding to example 1;
FIG. 6 shows a surface profile of Niu Yabiao after acid etching corresponding to example 3;
FIG. 7 shows a surface profile of Niu Yabiao after acid etching corresponding to example 5;
FIG. 8 shows a surface profile of Niu Yabiao after acid etching corresponding to comparative example 1;
FIG. 9 shows a surface profile of Niu Yabiao after acid etching corresponding to comparative example 2;
FIG. 10 shows a graph of bovine tooth surface morphology at 1k x electron microscope after the plugging experiment corresponding to example 1;
FIG. 11 shows a graph of bovine tooth surface morphology at 1k x electron microscope after the plugging experiment corresponding to example 3;
FIG. 12 shows a graph of bovine tooth surface morphology at 1k x electron microscope after the plugging experiment corresponding to example 5;
FIG. 13 shows a graph of bovine tooth surface morphology under a1 k-time electron microscope after a plugging experiment corresponding to comparative example 1;
Fig. 14 shows a graph of bovine tooth surface morphology under a1 k-power electron microscope after a plugging experiment corresponding to comparative example 2.
As can be seen from the above scanning electron microscope, the embodiment of example 1 almost well seals the dental tubule, and the effect of sealing the dental tubule is significantly better than that of comparative examples 1 and 2. While comparative example 1 is superior to bioactive glass-free active ingredients, the blocking effect is the worst, and only weak blocking behavior can be produced by means of sodium monofluorophosphate already contained in the formulation components, and the blocking effect of the single-tube water-free tube of comparative example 2 is also significantly worse than that of example 1, thus it can be demonstrated that the paste premixed in advance is liable to cause activity loss. The content of the bioactive glass of the anhydrous pipe in the double pipe of the example 3 and the example 5 is 1%, the final plugging effect of the example 5 is better than that of the example 3, and the difference of the two formulas for causing plugging behavior is that the water-containing formula of the example 5 has more 25% of water than the 5% of the additive amount of the example 3, so that the activating plugging effect on the bioactive glass is better. The bioactive glass content of the main functional components of examples 3 and 5 is lower, so that the plugging effect is inferior to that of other examples with high bioactive glass content. However, in the case of examples 3 and 5 in which the addition amount of the bioactive glass was extremely low (1%) relative to comparative example 2, the effect was still superior to the blocking effect of the addition amount of the bioactive glass of comparative example 2, which was higher (3%). Therefore, the scheme of the application can reduce the dosage of the bioactive glass, and can improve the blocking effect of the toothpaste under extremely low conditions, thereby effectively improving the dentin sensitivity resisting effect of the toothpaste.
(2) Further adopting the fresh bovine tooth cutting, grinding and polishing process, carrying out acid etching, confirming that the dental tubule of the bovine tooth piece is exposed through a scanning electron microscope, placing the bovine tooth in an oral cavity biomembrane in-vitro model, and continuously culturing oral resident bacteria streptococcus mutans, porphyromonas gingivalis, streptococcus salivarius, streptococcus sanguinis and actinomyces naeus, wherein the streptococcus salivarius and the streptococcus sanguinis are pioneer bacteria formed by oral bacterial plaques, the actinomyces naeus mediates the accumulation of various streptococcus in bacterial plaques, the porphyromonas gingivalis can cause gingivitis, and the streptococcus mutans is main cariogenic bacteria. The simple biofilm thus formed on the bovine dental film should be representative to a certain extent. Then adopting the dyeing liquid prepared by the standard of the laboratory evaluation method for the effect of removing exogenous color spots by adopting the toothpaste efficacy evaluation of the oral cleaning care products TCOCIA-2020, and adopting a scanning electron microscope to test after carrying out the tooth brushing test operation of 1-6 after dyeing for 2 days.
FIG. 15 shows the corresponding post-etch Niu Yabiao surface profile of example 1;
FIG. 16 shows the corresponding post-etch Niu Yabiao surface profile of example 2;
FIG. 17 shows a graph of bovine tooth surface morphology at 1k x electron microscope after the plugging experiment corresponding to example 1;
fig. 18 shows a graph of bovine tooth surface morphology at 1k x electron microscope after the plugging experiment corresponding to example 2.
From the above experimental results, it can be seen that both example 1 and example 2 achieve effective dentin tube occlusion. The scheme of the application can truly realize 'root cause control' and dentin sensitivity resistance.
Furthermore, the formulation combination of example 1 uses a small amount of peroxide and a catalyst auxiliary agent to release free radicals, so that the mineralization of the anti-allergic active ingredient is more facilitated after the stains on the tooth surface are oxidized, dissolved and removed. While example 2 also achieved good occlusion, it failed to occlude the exposed areas of larger dentin caliber. This indicates that plaque and stains formed on the pore surface can seriously block the targeted mineralization blocking effect of the bioactive glass when the dentin pore diameter is larger. The small amount of peroxide and catalyst auxiliary agent compounded in the embodiment 1 can realize the targeted mineralization blocking effect of firstly removing bacterial plaque and stains and then improving the bioactive glass. Is more suitable for dental plaque and dental environments with serious dental stains of organic isolation layers.
The above description is only of the preferred embodiments of the present application and is not intended to limit the present application, but various modifications and variations can be made to the present application by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application should be included in the protection scope of the present application.
Claims (50)
1. An anti-dentinal sensitivity toothpaste comprising:
The extruding container comprises a container body, at least two subchambers are arranged along the extending direction of the container body, the first paste and the second paste are respectively contained in one subchamber, the first paste comprises bioactive glass and a first carrier acceptable by toothpaste, the first paste does not contain water, and the second paste comprises water and a second carrier acceptable by toothpaste.
2. The anti-dentin-sensitivity toothpaste according to claim 1, wherein,
The adding amount of the water in the second paste is 5% -25% by mass.
3. The anti-dentin-sensitivity toothpaste according to claim 1, wherein,
The adding amount of the water in the second paste is 15% -25% by mass.
4. The anti-dentin-sensitivity toothpaste according to claim 1, wherein,
The addition amount of the bioactive glass in the first paste is 1% -10% by mass.
5. The anti-dentin-sensitivity toothpaste according to claim 1, wherein,
The bioactive glass comprises the following raw materials ：SiO2 40％～60％、CaO 20％～30％、P2O5 5％～12％、Na2O8％～13％、ZnO 0.5％～1.5％、SnO2 0.5％～1.5％、SrO 0.5％～1.5％ and 0.5% -1.5% of F by mass percent.
6. The dentin-sensitive toothpaste according to claim 1, further comprising a soluble potassium salt, wherein the addition amount of the soluble potassium salt is 2% -15% by mass.
7. The dentin-resistant toothpaste according to claim 6, wherein the soluble potassium salt is added in an amount of 5% -15% by mass in the second paste.
8. The anti-dentin-sensitivity toothpaste according to claim 6, wherein,
The soluble potassium salt comprises at least one of potassium nitrate, potassium chloride or potassium fluoride.
9. The anti-dentin-sensitivity toothpaste according to claim 1, wherein,
The first paste also comprises a whitening and stain removing component.
10. The anti-dentin sensitivity toothpaste according to claim 9, wherein,
The whitening and stain removing component comprises peroxide.
11. The dentin-resistant toothpaste according to claim 10, wherein the peroxide is added to the first paste in an amount of 2-10% by mass and the hydrogen peroxide content is lower than 2% by mass.
12. The anti-dentin sensitivity toothpaste according to claim 10, wherein,
The peroxide comprises at least one of hydrogen peroxide or a complex of hydrogen peroxide.
13. The anti-dentin sensitivity toothpaste according to claim 12, wherein,
The hydrogen peroxide complex comprises at least one of polyvinylpyrrolidone-hydrogen peroxide complex or carbamide peroxide.
14. The anti-dentin-sensitivity toothpaste according to claim 1, wherein,
The second paste further comprises a low-valence metal salt.
15. The anti-dentin sensitivity toothpaste according to claim 14, wherein,
The low-valence metal salt includes a stannous salt.
16. The anti-dentin sensitivity toothpaste according to claim 15, wherein,
The stannous salt comprises at least one of stannous chloride or stannous fluoride.
17. The anti-dentin sensitivity toothpaste according to claim 14, wherein,
The addition amount of the low-valence metal salt in the second paste is 0.01-0.45% by mass percent.
18. The anti-dentin-sensitivity toothpaste according to claim 1, wherein,
The second paste also comprises alkaline salts.
19. The anti-dentin sensitivity toothpaste according to claim 18, wherein,
The addition amount of the alkaline salt in the second paste is 0.6-8% by mass percent.
20. The anti-dentin sensitivity toothpaste according to claim 18, wherein,
The alkaline salt comprises at least one of carbonate or bicarbonate.
21. The anti-dentin sensitivity toothpaste according to claim 20, wherein,
The carbonate comprises at least one of sodium carbonate or potassium carbonate, and the bicarbonate comprises at least one of sodium bicarbonate, potassium bicarbonate, magnesium bicarbonate or calcium bicarbonate.
22. The anti-dentin sensitivity toothpaste according to claim 20, wherein,
The second paste comprises the carbonate and the bicarbonate, wherein the adding amount of the carbonate is 0.1-3.0%, the adding amount of the bicarbonate is 0.5-5%, or the weight percentage of the bicarbonate in the second paste is calculated
The second paste comprises the carbonate, wherein the adding amount of the carbonate in the second paste is 0.1% -8.0% by mass percent, or
The second paste comprises the bicarbonate, wherein the adding amount of the bicarbonate in the second paste is 0.5% -8.0% by mass.
23. The anti-dentin-sensitivity toothpaste according to claim 1, wherein,
The second paste further comprises an anionic foaming agent.
24. The anti-dentin sensitivity toothpaste according to claim 23, wherein,
The addition amount of the anionic foaming agent in the second paste is 2% -5% by mass.
25. The anti-dentin sensitivity toothpaste according to claim 23, wherein,
The anionic foaming agent comprises at least one of sodium lauryl sulfate, sodium lauroyl sarcosinate or sodium methyl cocoyl taurate.
26. The anti-dentin-sensitivity toothpaste according to claim 1, wherein,
The second paste also comprises betaines.
27. The anti-dentin sensitivity toothpaste according to claim 26, wherein,
The addition amount of the betaine is 0.2% -5.0% in the second paste by mass percent.
28. The anti-dentin sensitivity toothpaste according to claim 26, wherein,
The betaine comprises at least one of trimethylglycine, trialkylammonium inner salt, tetramethylammonium hydroxide or tetramethylammonium hydroxide.
29. The anti-dentin-sensitivity toothpaste according to claim 1, wherein,
The first paste also comprises carboxymethyl chitosan.
30. The anti-dentin sensitivity toothpaste according to claim 29, wherein,
The addition amount of the carboxymethyl chitosan in the first paste is 0.1-2.0% by mass percent.
31. The anti-dentin sensitivity toothpaste according to any one of claims 1 to 30, wherein,
The first carrier comprises humectant, thickener, friction agent, emulsifying agent, or
The first carrier comprises a humectant, a thickener, an abrasive, an emulsifier and a soluble zinc salt.
32. The anti-dentin sensitivity toothpaste according to any one of claims 1 to 30, wherein,
The first paste comprises, by mass, 1% -10% of bioactive glass, 61% -85% of a humectant, 4.3% -11% of a thickener, 5% -10% of an abrasive, 1% -8% of an emulsifier, and 0.12% -0.38% of a soluble zinc salt.
33. The anti-dentin sensitivity toothpaste according to claim 32, wherein,
The humectant comprises at least one of propylene glycol, polyethylene glycols, sorbitol or glycerol.
34. The anti-dentin sensitivity toothpaste according to claim 32, wherein,
The thickener comprises at least one of thickening silica, carbomer, xanthan gum, cellulose gum, carrageenan, hydroxyethyl cellulose or polyvinylpyrrolidone.
35. The anti-dentin sensitivity toothpaste according to claim 32, wherein,
The friction agent comprises at least one of calcium hydrophosphate, calcium carbonate, calcium pyrophosphate or friction type silicon dioxide.
36. The anti-dentin sensitivity toothpaste according to claim 32, wherein,
The emulsifier comprises at least one of PEG-60 hydrogenated castor oil or PEG-40 hydrogenated castor oil.
37. The anti-dentin sensitivity toothpaste according to claim 32, wherein,
The soluble zinc salt comprises at least one of zinc citrate, zinc chloride or zinc fluoride.
38. The anti-dentin sensitivity toothpaste according to any one of claims 1 to 30, wherein,
The second carrier comprises humectant, thickener, appearance improving agent, and friction agent, or
The second carrier comprises a humectant, a thickener, an appearance modifying agent, a friction agent and a soluble zinc salt.
39. The anti-dentin sensitivity toothpaste according to any one of claims 1 to 30, wherein,
The second paste comprises the following components in percentage by mass:
5% -25% of water, 2% -15% of soluble potassium salt, 35% -60% of humectant, 4.5% -12.5% of thickener, 0.2% -0.8% of appearance modifier, 5% -15% of friction agent and 0.12% -0.38% of soluble zinc salt.
40. The dentin-resistant toothpaste according to claim 39, wherein,
The humectant comprises at least one of glycerol, sorbitol, glycerol, polyethylene glycol or propylene glycol.
41. The dentin-resistant toothpaste according to claim 39, wherein,
The thickener comprises at least one of xanthan gum, carbomer, carrageenan, cellulose gum, hydroxyethyl cellulose, thickening silica or polyvinylpyrrolidone.
42. The dentin-resistant toothpaste according to claim 39, wherein,
The appearance improver comprises titanium dioxide.
43. The dentin-resistant toothpaste according to claim 39, wherein,
The friction agent comprises at least one of friction type silicon dioxide, calcium hydrophosphate, calcium carbonate or calcium pyrophosphate.
44. The dentin-resistant toothpaste according to claim 39, wherein,
The soluble zinc salt comprises at least one of zinc citrate, zinc chloride or zinc fluoride.
45. The anti-dentin sensitivity toothpaste according to any one of claims 1 to 30, wherein,
The extrusion container also comprises a cover plate, a transmission extrusion structure and a partition plate;
The partition board is arranged in the cavity and is used for dividing the cavity into at least two subchambers along the extending direction of the container body, and the subchambers are communicated with the outlet of the container body;
the cover plate is detachably connected with the tail part of the container body through a connecting structure and is sealed;
The transmission extrusion structure is arranged in the container body and is movably connected with the cover plate, and the transmission extrusion structure is used for extruding the first paste and the second paste in the cavity from the outlet.
46. The dentin-resistant toothpaste according to claim 45, wherein,
The transmission extrusion structure comprises a transmission part and a piston, wherein one end of the transmission part is movably connected with the cover plate, the transmission part is arranged in the cavity along the extending direction of the container body, the piston is in transmission connection with the transmission part, and the transmission part drives the piston to advance or retreat along the extending direction of the axis of the transmission part so as to extrude the first paste and the second paste.
47. The dentin-resistant toothpaste according to claim 45, wherein,
The toothpaste for preventing dentin sensitivity comprises a base;
the base comprises a base body;
A driving member provided in the base body;
The transmission structure is arranged in the base body and is connected with the driving part; the transmission structure is provided with a butt joint part, and the butt joint part is used for being fixedly connected with the transmission extrusion structure in the extrusion container when the base is assembled with the extrusion container; the driving part drives the transmission structure, so as to further drive the transmission extrusion structure fixedly connected with the butting part, and the extrusion of the first paste and the second paste is realized;
The control module is arranged in the base body and is electrically connected with the driving component;
And the power supply module is arranged in the base body and is respectively and electrically connected with the control module and the driving part.
48. The anti-dentin sensitive toothpaste according to claim 47, wherein,
The transmission structure comprises a bracket and a transmission part, wherein the transmission part is arranged on the bracket, the output end of the driving part penetrates through the bracket, the output end of the driving part is connected with the transmission part, and the butt joint part is arranged at one end, far away from the output end of the driving part, of the transmission part.
49. A preparation method of dentin-sensitive toothpaste is characterized in that,
The dentin-resistant toothpaste comprises:
extruding a container, a first paste and a second paste;
the squeeze container includes a container body;
at least two subchambers are arranged along the extending direction of the container body, and the first paste and the second paste are respectively accommodated in one subchamber;
The first paste comprises bioactive glass and a first carrier acceptable by toothpaste, and the first paste does not contain water; the second paste comprises water and a second carrier acceptable by toothpaste;
The preparation method comprises the following steps:
And injecting the first paste into one of the subchambers, and injecting the second paste into the other subchamber.
50. The method for preparing dentin-sensitive toothpaste according to claim 49, wherein,
The adding amount of the water in the second paste is 5% -25% by mass.
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| US9138428B2 (en) * | 2010-08-07 | 2015-09-22 | The Research Foundation For The State University Of New York | Oral compositions comprising a zinc compound and an anti-microbial agent |
| MA33231B1 (en) * | 2010-09-20 | 2012-05-02 | Univ Hassan Ii Mohammedia | BIOVERRE-BASED MACROPOROUS CEMENTS, BIOACTIVE, BIORESORBABLE FOR BIOMEDICAL USE |
| CN108743408A (en) * | 2018-09-01 | 2018-11-06 | 金旭环保制品（深圳）有限公司 | A kind of tooth whitening moistening cleaning tissue |
| CN112826751B (en) * | 2021-01-28 | 2022-07-22 | 重庆登康口腔护理用品股份有限公司 | Anti-allergy toothpaste capable of enhancing fluorine activity |
| CN113827492B (en) * | 2021-11-29 | 2022-03-15 | 诺一迈尔(山东)医学科技有限公司 | Tooth desensitizing composition and preparation method thereof |
| CN117205110A (en) * | 2023-08-24 | 2023-12-12 | 杭州纳美智康科技有限公司 | Dental antiallergic composition and antiallergic toothpaste |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111093604A (en) * | 2017-08-18 | 2020-05-01 | 荷兰联合利华有限公司 | Oral care compositions |
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