CN119112432A

CN119112432A - Magnesium alloy balloon-expandable esophageal stent based on microsphere drug-loaded technology

Info

Publication number: CN119112432A
Application number: CN202410878190.0A
Authority: CN
Inventors: 张韬
Original assignee: Shanghai Fangao Information Technology Co ltd
Current assignee: Shanghai Fangao Information Technology Co ltd
Priority date: 2024-07-02
Filing date: 2024-07-02
Publication date: 2024-12-13

Abstract

The present invention relates to the field of medical device technology, specifically to a magnesium alloy balloon expandable esophageal stent based on microsphere drug loading technology, including a balloon; a stent assembly, the stent assembly includes a plurality of annular stents and a plurality of threading holes are opened inside the annular stent and the threading holes completely penetrate the annular stent, each of the threading holes is distributed in an annular array with the center of the annular circle surrounded by the annular stent; a drug injection assembly, the drug injection assembly includes a connecting wire and a protruding handle, and the protruding handle is fixedly connected with a microsphere on one side away from the connecting wire. The magnesium alloy balloon expandable esophageal stent based on microsphere drug loading technology, the annular stent, the lifting stent, the connecting wire, the collar, the protruding handle and the microsphere are made of magnesium alloy (Mg-Zn-Mn-C/Zr), the Mg content in the magnesium alloy is more than 95%, can be naturally absorbed and degraded by the human body, and uniformly degrades in about one to three months without removal to avoid secondary damage to the patient, and at the same time, a trace amount of hydrogen is generated during the degradation process of the magnesium alloy, which has a cell repair effect.

Description

Magnesium alloy saccule expansion type esophagus support based on microsphere medicine carrying technology

Technical Field

The invention relates to the technical field of medical appliances, in particular to a magnesium alloy balloon expandable esophageal stent based on microsphere drug-loading technology.

Background

At present, when esophageal cancer is treated, an esophageal stent is generally used for treating the esophageal cancer, the esophageal stent is generally made of nickel-titanium memory alloy, and the esophageal stent is generally implanted to relieve symptoms such as esophageal stenosis or esophageal fistula and help a patient recover normal diet and digestive functions.

The existing method for preventing the esophageal stent from displacement generally comprises the steps of fixing the esophageal stent on the inner wall of the esophagus through metal barbs, wherein the method can cause damage to tissues of the inner wall of the esophagus, and meanwhile, most of esophageal stents are mainly self-expanding, the mode can lead to lower fitting degree of the stent and the esophagus wall, most of materials of the esophageal stent are nickel-titanium alloy, the esophageal stent is non-degradable, later extraction is difficult, and the esophageal tissue is secondarily influenced.

Disclosure of Invention

The invention aims to provide a magnesium alloy saccule expanding type esophagus support based on a microballoon drug loading technology, so as to solve the problems that solid garbage and waste garbage are inconvenient to collect and decompose in daily household life, and the environment is endangered and the classification is inconvenient to manually carry out in the background technology. In order to achieve the aim, the invention provides the technical scheme that the magnesium alloy balloon expandable esophageal stent based on the microsphere drug loading technology comprises a balloon;

The bracket assembly comprises a plurality of annular brackets, a plurality of wire penetrating holes are formed in the annular brackets, the wire penetrating holes completely penetrate through the annular brackets, and each wire penetrating hole is distributed in an annular array with the circle center of an annular shape surrounded by the annular brackets;

The medicine injection assembly comprises a connecting wire and a convex handle, and a microsphere is fixedly connected to one side, far away from the connecting wire, of the convex handle.

Further preferably, a lifting bracket is fixedly connected between each two adjacent annular brackets, the connecting wires completely penetrate through each annular bracket through wire penetrating holes in the annular brackets, and the head end and the tail end of each connecting wire are respectively fixedly connected with the two annular brackets and are movably connected with the rest annular brackets.

Further preferably, the side surface of the connecting wire is fixedly sleeved with a plurality of lantern rings, the side surface of the lantern rings is fixedly connected with the convex handle, a hollow cavity for storing medicines is formed in the microsphere, a plurality of nanoscale micropores are formed in the surface of the microsphere and are communicated with the hollow cavity in the microsphere, the esophageal stent is arranged in a balloon type, the efficiency is high during endoscopy, the fitting degree is high, the mounting position is more accurate, meanwhile, a magnesium alloy material (Mg-Zn-Mn-C/Zr) without rare earth and aluminum elements is used, the clinical requirements are completely met by the supportability and stress distribution, the hydrogen generated in the magnesium alloy degradation process is beneficial to sterilization and cell tissue repair, and the magnesium element naturally exists in a human body and has good cell compatibility.

Further preferably, the balloon is fixedly sleeved with a guide tube, the guide tube is a hollow tube, and an inflation port for inflating the balloon is formed in the side surface of the guide tube and is communicated with the inside of the guide tube.

Further preferably, the outside of support subassembly is provided with the film subassembly, the film subassembly includes medical tectorial membrane, medical tectorial membrane cladding is at the side surface of annular support and pull-up support and the annular support fixed connection at medical tectorial membrane and connecting wire both ends, a plurality of perforation and protruding handle penetration perforation have been seted up to the inside of medical tectorial membrane.

Compared with the prior art, the invention has the beneficial effects that:

In the invention, the annular bracket, the lifting bracket, the connecting wire, the lantern ring, the convex handle and the microsphere are made of magnesium alloy (Mg-Zn-Mn-C/Zr), wherein the Mg content in the magnesium alloy is more than 95 percent, the magnesium alloy can be naturally absorbed and degraded by a human body, the magnesium alloy can be uniformly degraded for about one to three months without taking out the magnesium alloy to avoid secondary injury to a patient, and simultaneously, the magnesium alloy degradation process generates trace hydrogen to have a cell repairing effect;

In the invention, the medical coating is also a degradable material, can be degraded gradually with time, reduces the process of taking out the stent in the later stage, replaces the traditional esophageal stent made of nickel-titanium memory alloy to fix by using a barb mode, increases the friction force with the inner wall of the esophagus through a plurality of microspheres, ensures that displacement can not occur in the early stage of treatment, reduces the damage to the inner wall of the esophagus, adopts the balloon expansion mode for installation, has more excellent installation quality compared with most of the existing self-expanding stents, and has lower operation error rate.

Drawings

FIG. 1 is a schematic perspective view of the present invention;

FIG. 2 is a schematic view of a medical film structure according to the present invention;

FIG. 3 is a schematic diagram of the structure of the drug injection assembly of the present invention;

FIG. 4 is a schematic view of a bracket assembly according to the present invention;

FIG. 5 is a schematic view of the balloon and guide tube structure of the present invention;

FIG. 6 is a schematic view of a partially enlarged structure of the drug injection assembly of the present invention;

FIG. 7 is a schematic cross-sectional view of the present invention.

In the figure, 1, a balloon, 2, a bracket component, 3, a medicine injection component, 4, a film component, 5, a guide tube, 6, a blowing port, 201, an annular bracket, 202, a lifting bracket, 203, a threading hole, 301, a connecting wire, 302, a lantern ring, 303, a convex handle, 304, microspheres, 401, a medical coating film, 402 and perforation.

Detailed Description

The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which are obtained by a worker of ordinary skill in the art without creative efforts, are within the protection scope of the present invention based on the embodiments of the present invention.

Referring to fig. 1-7, the invention provides a magnesium alloy balloon expandable esophageal stent based on microsphere drug loading technology, which comprises a balloon 1, a stent component 2, a drug injection component 3, wherein the stent component 2 comprises a plurality of annular stents 201, a plurality of wire through holes 203 are formed in the annular stents 201, the wire through holes 203 completely penetrate the annular stents 201, each wire through hole 203 is distributed in an annular array with the circle center of an annular shape surrounded by the annular stents 201, the drug injection component 3 comprises a connecting wire 301 and a convex handle 303, and one side of the convex handle 303 far away from the connecting wire 301 is fixedly connected with microspheres 304.

In this embodiment, as shown in fig. 4 and 7, a lifting support 202 is fixedly connected between each adjacent annular support 201, a connection wire 301 completely penetrates through each annular support 201 through a wire penetrating hole 203 on the annular support 201, the head and tail ends of the connection wire 301 are respectively and fixedly connected with two annular supports 201, the connection wire 301 is movably connected with the rest annular supports 201, the esophageal support is installed in a balloon type manner during endoscopy, the efficiency is high, the fitting degree is high, the installation position is more accurate, meanwhile, a magnesium alloy material (Mg-Zn-Mn-C/Zr) without rare earth and aluminum elements is used, the safety and reliability are realized, the supportability and stress distribution completely meet clinical requirements, hydrogen generated in the magnesium alloy degradation process is favorable for sterilization and cell tissue repair, and the magnesium element naturally exists in a human body and has good cell compatibility.

In this embodiment, as shown in fig. 3, 6 and 7, a plurality of collars 302 are fixedly sleeved on the side surface of the connection wire 301, and the side surfaces of the collars 302 are fixedly connected with the convex handles 303, hollow cavities for storing medicines are formed inside the microspheres 304, a plurality of nano-scale micropores are formed on the surfaces of the microspheres 304, and the nano-scale micropores are communicated with the hollow cavities inside the microspheres 304.

In this embodiment, as shown in fig. 1, 5 and 7, the inside of the balloon 1 is fixedly sleeved with a guide tube 5, the guide tube 5 is a hollow tube, the side surface of the guide tube 5 is provided with an inflation port 6 for inflating the balloon 1, the inflation port 6 is communicated with the inside of the guide tube 5, when the device is used, the device is sent to a patient of an esophagus through the guide tube 5, the balloon 1 is inflated through the inflation port 6 on the guide tube 5 by introducing air into the guide tube 5, the contracted annular bracket 201 is expanded while the balloon 1 is inflated, the annular bracket 201 and the lifting bracket 202 are expanded, the lantern ring 302, the convex handle 303 and the microsphere 304 are connected in series through the connecting wire 301, the microsphere 304 is firstly contacted with the inner wall of the esophagus while the annular bracket 201 is expanded, the medical coating 401 is contacted with the inner wall of the esophagus and the narrow position of the esophagus is spread by the unfolded annular bracket 201, then the gas in the balloon 1 is pumped out by the guide tube 5, so that the guide tube 5 and the balloon 1 are pumped out from the inner parts of the annular bracket 201 and the lifting bracket 202, the microsphere 304 is injected with therapeutic drugs in the inner cavity of the annular bracket 201 before operation, the microsphere 304 is directly contacted with the inner wall of the esophagus after being implanted into the esophagus, so that the microsphere 304 slowly releases the drugs to the focus position for continuous treatment under the actions of nanometer micropores coated on the surface and gradual decomposition, and the annular bracket 201, the lifting bracket 202, the connecting wire 301, the collar 302, the convex handle 303 and the microsphere 304 adopt magnesium alloy metal with more than ninety-five percent of magnesium content, so that the medical coating is easy to be decomposed and metabolized, and the medical coating can be taken out after the patient is recovered without secondary operation.

In this embodiment, as shown in fig. 1,2 and 7, a film component 4 is disposed on the outer side of the bracket component 2, the film component 4 includes a medical film 401, the medical film 401 is wrapped on the side surfaces of the annular bracket 201 and the lifting bracket 202, and the medical film 401 is fixedly connected with the annular bracket 201 at two ends of the connecting wire 301, a plurality of through holes 402 are formed in the medical film 401, and the convex handle 303 penetrates through the through holes 402.

The magnesium alloy saccule expansion type esophagus support based on the microsphere medicine carrying technology has the advantages that when in use, the magnesium alloy saccule expansion type esophagus support based on the microsphere medicine carrying technology has the following working process:

As shown in fig. 1,2,3, 4,5, 6 and 7, the device is delivered to a patient of the esophagus through the guide tube 5 when in use, the balloon 1 is inflated through the inflation port 6 on the guide tube 5 by introducing gas into the guide tube 5, the contracted annular support 201 is expanded while the balloon 1 is inflated, the annular support 201 and the pull-up support 202 are expanded, the collar 302, the lug 303 and the microspheres 304 are connected in series through the connecting wire 301, the microspheres 304 are firstly contacted with the inner wall of the esophagus while the annular support 201 is expanded, then the medical coating 401 is contacted with the inner wall of the esophagus and the narrow position of the esophagus is expanded through the expanded annular support 201, and then the gas in the balloon 1 is pumped out through the guide tube 5, so that the guide tube 5 and the balloon 1 are pumped out from the annular support 201 and the lifting support 202, the therapeutic medicine is injected into the inner cavity of the microsphere 304 before the operation, and after the microsphere 304 is implanted into the esophagus, the microsphere 304 slowly releases the medicine to the focus position for continuous treatment under the actions of nano-level micropores coated on the surface and gradual decomposition of the microsphere 304 due to the direct contact of the microsphere 304 and the inner wall of the esophagus, and the annular support 201, the lifting support 202, the connecting wire 301, the lantern ring 302, the convex handle 303 and the magnesium alloy metal with the magnesium content of more than ninety-five percent are adopted by the microsphere 304, so that the microsphere is easy to be decomposed and metabolized, and the microsphere 304 is taken out after the patient is recovered without secondary operation.

The foregoing has shown and described the basic principles, principal features and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the above-described embodiments, and that the above-described embodiments and descriptions are only preferred embodiments of the present invention, and are not intended to limit the invention, and that various changes and modifications may be made therein without departing from the spirit and scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims

1. A magnesium alloy balloon-expandable esophageal stent based on microsphere drug-loaded technology, characterized in that it comprises a balloon (1);

A support assembly (2), the support assembly (2) comprising a plurality of annular supports (201), the annular supports (201) being provided with a plurality of threading holes (203) inside, the threading holes (203) completely passing through the annular supports (201), each of the threading holes (203) being distributed in an annular array with the center of the annular circle surrounded by the annular supports (201);

The drug injection component (3) comprises a connecting wire (301) and a protruding handle (303), wherein a micro-ball (304) is fixedly connected to a side of the protruding handle (303) away from the connecting wire (301).

2. According to the magnesium alloy balloon-expandable esophageal stent based on microsphere drug-loaded technology as described in claim 1, it is characterized in that: a lifting bracket (202) is fixedly connected between each adjacent annular bracket (201), and the connecting wire (301) completely penetrates each annular bracket (201) through the wire threading hole (203) on the annular bracket (201), and the head and tail ends of the connecting wire (301) are respectively fixedly connected to the two annular brackets (201) and the connecting wire (301) is movably connected to the remaining annular brackets (201).

3. According to claim 1, the magnesium alloy balloon expandable esophageal stent based on microsphere drug loading technology is characterized in that: the side surface of the connecting wire (301) is fixedly sleeved with a plurality of rings (302) and the side surface of the rings (302) is fixedly connected to the protruding handle (303), the inside of the microsphere (304) is provided with a hollow cavity for storing drugs, the surface of the microsphere (304) is provided with a plurality of nano-scale micropores and the nano-scale micropores are connected to the hollow cavity inside the microsphere (304).

4. The magnesium alloy balloon-expandable esophageal stent based on microsphere drug-loaded technology according to claim 1 is characterized in that: a guide tube (5) is fixedly sleeved inside the balloon (1), and the guide tube (5) is a hollow tube. A blowing port (6) for inflating the balloon (1) is provided on the side surface of the guide tube (5), and the blowing port (6) is connected to the inside of the guide tube (5).

5. According to claim 1, the magnesium alloy balloon expandable esophageal stent based on microsphere drug loading technology is characterized in that: a film component (4) is arranged on the outside of the stent component (2), and the film component (4) includes a medical coating (401), and the medical coating (401) is coated on the side surfaces of the annular stent (201) and the lifting stent (202), and the medical coating (401) is fixedly connected to the annular stent (201) at both ends of the connecting wire (301), and a plurality of through holes (402) are opened inside the medical coating (401), and the protruding handle (303) passes through the through holes (402).