CN118962160A - A fully automatic blood donation screening and joint testing device - Google Patents
A fully automatic blood donation screening and joint testing device Download PDFInfo
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- CN118962160A CN118962160A CN202411306430.6A CN202411306430A CN118962160A CN 118962160 A CN118962160 A CN 118962160A CN 202411306430 A CN202411306430 A CN 202411306430A CN 118962160 A CN118962160 A CN 118962160A
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- 210000004369 blood Anatomy 0.000 title claims abstract description 187
- 239000008280 blood Substances 0.000 title claims abstract description 187
- 238000012216 screening Methods 0.000 title claims abstract description 30
- 238000012360 testing method Methods 0.000 title claims description 6
- 239000000523 sample Substances 0.000 claims abstract description 303
- 230000007246 mechanism Effects 0.000 claims abstract description 130
- 238000001514 detection method Methods 0.000 claims abstract description 116
- 239000000427 antigen Substances 0.000 claims abstract description 67
- 102000036639 antigens Human genes 0.000 claims abstract description 67
- 108091007433 antigens Proteins 0.000 claims abstract description 67
- 208000002672 hepatitis B Diseases 0.000 claims abstract description 60
- 239000003153 chemical reaction reagent Substances 0.000 claims description 92
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 47
- 108090000340 Transaminases Proteins 0.000 claims description 36
- 238000004140 cleaning Methods 0.000 claims description 30
- 238000005406 washing Methods 0.000 claims description 26
- 206010018910 Haemolysis Diseases 0.000 claims description 25
- 230000008588 hemolysis Effects 0.000 claims description 25
- 108010004103 Chylomicrons Proteins 0.000 claims description 13
- 230000002949 hemolytic effect Effects 0.000 claims description 12
- 102000001554 Hemoglobins Human genes 0.000 claims description 9
- 108010054147 Hemoglobins Proteins 0.000 claims description 9
- 208000006454 hepatitis Diseases 0.000 claims description 7
- 231100000283 hepatitis Toxicity 0.000 claims description 7
- 239000006228 supernatant Substances 0.000 claims description 6
- 206010009168 Chyluria Diseases 0.000 claims description 5
- 210000003743 erythrocyte Anatomy 0.000 claims description 5
- 238000005119 centrifugation Methods 0.000 claims description 4
- 102000003929 Transaminases Human genes 0.000 claims 5
- 238000007423 screening assay Methods 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 19
- 238000007689 inspection Methods 0.000 abstract description 8
- 102000014898 transaminase activity proteins Human genes 0.000 description 31
- 238000003756 stirring Methods 0.000 description 23
- 239000007788 liquid Substances 0.000 description 19
- 230000009977 dual effect Effects 0.000 description 12
- 238000010438 heat treatment Methods 0.000 description 9
- 238000005259 measurement Methods 0.000 description 9
- 238000010586 diagram Methods 0.000 description 8
- 238000009434 installation Methods 0.000 description 7
- 239000008213 purified water Substances 0.000 description 7
- 239000000203 mixture Substances 0.000 description 6
- 238000013019 agitation Methods 0.000 description 4
- 230000003321 amplification Effects 0.000 description 4
- 238000003199 nucleic acid amplification method Methods 0.000 description 4
- 239000002244 precipitate Substances 0.000 description 3
- 238000005057 refrigeration Methods 0.000 description 3
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 description 2
- 108010082126 Alanine transaminase Proteins 0.000 description 2
- 210000005056 cell body Anatomy 0.000 description 2
- 229910000365 copper sulfate Inorganic materials 0.000 description 2
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 2
- 239000003219 hemolytic agent Substances 0.000 description 2
- 230000001376 precipitating effect Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 238000004448 titration Methods 0.000 description 2
- 239000002351 wastewater Substances 0.000 description 2
- 241001552669 Adonis annua Species 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000001268 chyle Anatomy 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000004879 turbidimetry Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/82—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a precipitate or turbidity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5761—Hepatitis B
- G01N33/5764—Hepatitis B surface antigen
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
- G01N33/726—Devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1004—Cleaning sample transfer devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/01—DNA viruses
- G01N2333/02—Hepadnaviridae, e.g. hepatitis B virus
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Abstract
The invention provides a full-automatic blood donation primary screening joint inspection device, and belongs to the technical field of medical appliances. The invention comprises a mounting main body, a single needle probe mechanism arranged on the mounting main body a blood group module and a hepatitis B surface antigen detection module; the single needle probe mechanism can move along the horizontal and vertical directions of the mounting main body, is used for sucking the whole blood sample at the first position on the blood type module, and then dripping the first part of whole blood sample onto the hepatitis B surface antigen detection module for judging the nature of hepatitis B surface antigens. The invention draws the whole blood sample on the blood group module through the single needle probe mechanism and then drops the whole blood sample on the hepatitis B surface antigen detection module, so as to judge the nature of the hepatitis B surface antigen through the hepatitis B surface antigen detection module. The method realizes the detection of the hepatitis B surface antigen property and blood type in the primary screening joint inspection process, and relieves the technical problems of excessive blood and repeated blood adding detection in the follow-up detection.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a full-automatic blood donation primary screening joint inspection device.
Background
The gratuitous blood donation is a blood collection process of healthy people, and a preliminary blood test screening is carried out before the blood donation of a donor, wherein the blood donation at least comprises glutamic pyruvic transaminase, hemoglobin and chyle blood in human blood, and if one index is not met, the blood donation cannot be carried out. In the prior art, a dry biochemical analyzer is adopted for detecting glutamic pyruvic transaminase, 30ul of whole blood is sampled and added into a dry test strip, and then the whole blood is put into the dry biochemical analyzer for about 120 seconds to obtain a detection result. For hemoglobin, a visual observation is typically made using copper sulfate titration, i.e., a large drop of blood, approximately 50ul, is instilled into a copper sulfate solution to see if the blood is sinking to the bottom of the bottle or suspended in the solution to determine if the donor is anemic. Or detected by a hemoglobin detector.
However, in the prior art, in the project of preliminary screening and combined detection of blood donation, there is no project for observing the property of hepatitis B surface antigen, because of the property detection characteristic of hepatitis B surface antigen, the property detection of hepatitis B surface antigen can be carried out on a blood sample after blood collection is completed, so that the repeated operation of the blood sample detection process of a follow-up blood bag has the problems of excessive blood and multiple blood adding detection.
Disclosure of Invention
In view of the above, in order to solve the technical problems that the observation of hepatitis B surface antigen properties caused by the lack of the primary screening combined detection of blood donation in the prior art can cause the excessive use of blood and multiple blood adding detection in the subsequent detection, the invention provides a full-automatic primary screening combined detection device for blood donation, which is used for sucking a whole blood sample on a blood group module through a single needle probe mechanism and then dripping the whole blood sample on the blood group module onto a hepatitis B surface antigen detection module so as to judge the hepatitis B surface antigen properties through the hepatitis B surface antigen detection module. The method realizes the detection of the hepatitis B surface antigen property and blood type in the primary screening joint inspection process, and relieves the technical problems of excessive blood and repeated blood adding detection in the follow-up detection.
In order to achieve the above purpose, the present invention provides the following technical solutions:
A full-automatic blood donation primary screening joint inspection device comprises an installation main body, a single needle probe mechanism arranged on the installation main body, a blood type module and a hepatitis B surface antigen detection module;
The single needle probe mechanism can move along the horizontal direction and the vertical direction of the mounting main body and is used for dripping a first part of whole blood sample onto the hepatitis B surface antigen detection module after sucking the whole blood sample at a first position on the blood type module and judging the nature of hepatitis B surface antigens;
Further comprises:
a sample tray mechanism disposed on the mounting body, the sample tray mechanism having a centrifuge tube;
a double-needle probe mechanism provided on the mounting main body and movable in the horizontal and vertical directions of the mounting main body;
a hemolyzed chyluria module;
And the single-needle probe mechanism drops a third part of the sucked whole blood sample into the centrifuge tube, and after centrifugation, the double-needle probe mechanism sucks supernatant into the hemolysis chylomicron module for hemolysis and chylomicron detection.
Preferably, the single needle probe mechanism drops a second portion of whole blood sample into a second location on the blood group module for assisting an operator in determining blood group.
Preferably, the method further comprises:
a transaminase detection module;
After the detection of the hemolytic chylomicronemic module is completed, the double-needle probe mechanism absorbs the transaminase reagent and the mixed sample in the hemolytic chylomicronemic module, and the mixed sample is injected into the transaminase detection module to carry out transaminase detection.
Preferably, after the transaminase is detected, clear water is spitted into the centrifuge tube through the double-needle probe mechanism, and is mixed with red blood cells by stirring, and then sucked into the hemolysis chylomicronemic module for hemoglobin detection.
Preferably, the method further comprises:
and the probe cleaning system is arranged on the mounting main body and is used for cleaning the single-needle probe mechanism and the double-needle probe mechanism.
Preferably, the probe cleaning system comprises a first probe cleaning tank and a second probe cleaning tank for cleaning the single-needle probe mechanism and the double-needle probe mechanism, respectively.
Preferably, the hepatitis B surface antigen detection module comprises:
Hepatitis B surface antigen reagent strip;
The first camera and the second camera are positioned above the hepatitis B surface antigen reagent strip and used for observing the properties of the whole blood sample on the hepatitis B surface antigen reagent strip.
Preferably, the blood group module comprises:
The blood group reagent module is used for placing a plurality of reagents;
A duplex cup module having a blood type duplex cup for placing a whole blood sample for testing;
the first placing position and the second placing position are formed on the blood group duplex cup.
Preferably, the mounting body includes a base plate and a riser provided on the base plate;
the vertical plate comprises a main panel and an auxiliary panel which are mutually perpendicular and are arranged on the bottom plate;
The single-needle probe mechanism is arranged on the main panel and can move along the main panel in the horizontal and vertical directions.
Compared with the prior art, the invention has the following beneficial effects:
According to the full-automatic blood donation primary screening joint inspection device provided by the invention, the single-needle probe mechanism can move along the horizontal and vertical directions of the installation main body, and after the single-needle probe mechanism sucks the whole blood sample at the first position on the blood group module, the first part is dripped on the hepatitis B surface antigen detection module so as to judge the hepatitis B surface antigen property through the hepatitis B surface antigen detection module. The method realizes the detection of the hepatitis B surface antigen property and blood type in the primary screening combined detection process, and relieves the technical problems that the prior art has the defect of observing the hepatitis B surface antigen property due to the deficiency of the primary screening combined detection of blood donation, and the follow-up detection uses excessive blood and multiple blood adding detection.
After the single needle probe mechanism sucks the whole blood sample of the first place on the blood group module, the second part is dripped into the second place on the blood group module for assisting the staff in determining the blood group.
After the single-needle probe mechanism sucks the whole blood sample at the first position on the blood group module, the third part is dripped into a centrifuge tube of the sample tray mechanism, and the supernatant is sucked into the hemolysis chylomicron module through the double-needle probe mechanism for hemolysis and chylomicron detection.
The double-needle probe mechanism absorbs the mixed sample in the transaminase reagent and the hemolytic chylomicronemic module, and the mixed sample is injected into the transaminase detection module to carry out transaminase detection.
The double-needle probe mechanism spits clear water into the centrifuge tube, and after being stirred and mixed with red blood cells, the clear water is sucked into the hemolyzed chylomicron module for hemoglobin detection.
In summary, the full-automatic blood donation primary screening combined detection device provided by the invention can realize full automation of hepatitis B surface antigen property, blood type judgment, chylomicronemia detection, transaminase detection and hemoglobin detection, can improve the speed of blood detection, and can reduce the complexity of blood detection.
Drawings
FIG. 1 is a schematic diagram of the overall structure of the present invention;
FIG. 2 is a schematic view of the back structure of the present invention;
FIG. 3 is a schematic view of the sample tray mechanism of the present invention;
FIG. 4 is a schematic diagram of a dual needle probe mechanism of the present invention;
FIG. 5 is a schematic diagram of the front structure of the dual needle probe mechanism of the present invention;
FIG. 6 is a schematic diagram of a single needle probe mechanism of the present invention;
FIG. 7 is a schematic diagram of the front structure of a single needle probe mechanism of the present invention;
fig. 8 is a schematic structural view of a hemolyzed chylomicron module of the fully automatic blood donation primary screening device according to an embodiment of the invention;
FIG. 9 is a schematic diagram showing the structure of the transaminase detection module of the present invention;
FIG. 10 is a schematic view of the structure of a first probe cleaning tank according to the present invention;
FIG. 11 is a schematic diagram of the structure of a second probe cleaning tank according to the present invention;
FIG. 12 is a schematic view of a duplex cup module configuration of the present invention;
FIG. 13 is a schematic diagram of a blood group reagent module according to the present invention;
In the figure, 100, a mounting body; 101. a main panel; 102. a sub-panel; 200. a double needle probe mechanism; 201. a double needle moving body; 202. a double needle probe body; 203. a first two-position three-way electromagnetic valve; 204. a first plunger pump; 212. a first universal ball bearing; 222. a first single needle holder; 211. a first double needle holder; 232. a first stirring connection; 242. a first stirring motor; 252. a dual needle sample reagent probe; 262. a first water inlet needle; 272. a first drain needle; 282. a first hydraulic pump; 2821. a first diaphragm liquid pump; 2822. a second diaphragm liquid pump; 2823. a third diaphragm liquid pump; 2824. a fourth diaphragm liquid pump; 292. a second hydraulic pump; 2921. a fifth diaphragm liquid pump; 2922. a sixth diaphragm liquid pump; 300. a sample tray mechanism; 302. a turntable; 304. a sample rack; 306. centrifuging tube; 318. a high-speed centrifugal motor; 319. a centrifugal turntable protective cover; 400. a hepatitis b surface antigen detection module; 500. a blood group module; 510. a blood group reagent module; 511. a first reagent site; 512. a second reagent site; 520. a duplex cup module; 521. blood type duplex cup; 5211. a first placement bit; 5212. a second placement bit; 522. blood group duplex cup holder; 600. a hemolyzed chyluria module; 601. a cuvette; 602. a hemolytic chyluria detection led light source; 603. a photoelectric sensor; 604. a second signal amplifying circuit board; 700. a transaminase reagent refrigeration module; 800. a transaminase detection module; 801. a measurement circuit board; 802. a test strip; 803. a cuvette; 804. an LED light source; 900. A first probe cleaning tank; 901. a first main cell body; 902. a first water inlet pipe; 903. a first drain pipe; 1900. a second probe washing tank; 1901. a second main cell body; 1902. a second water inlet pipe; 1903. a second drain pipe; 1000. a single needle probe mechanism; 1101. a single needle moving body; 1102. a single needle probe body; 1103. a second two-position three-way electromagnetic valve; 1104. a second plunger pump; 1112. a second universal ball bearing; 1122. a second single needle fixing frame; 1132. a second stirring connection; 1142. a second stirring motor; 1152. single needle sample reagent probe.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention; it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments, and that all other embodiments obtained by persons of ordinary skill in the art without making creative efforts based on the embodiments in the present invention are within the protection scope of the present invention.
In the description of the present invention, it should be noted that the positional or positional relationship indicated by the terms such as "upper", "lower", "inner", "outer", "top/bottom", etc. are based on the positional or positional relationship shown in the drawings, are merely for convenience of describing the present invention and simplifying the description, and do not indicate or imply that the apparatus or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "configured to," "engaged with," "connected to," and the like are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention will be understood in specific cases by those of ordinary skill in the art.
As shown in fig. 1, the present invention provides a full-automatic blood donation primary screening combined detection device, which comprises a mounting main body 100, a single needle probe mechanism 1000 arranged on the mounting main body 100, a blood type module 500 and a hepatitis b surface antigen detection module 400;
the single needle probe mechanism 1000 can move along the horizontal and vertical directions of the mounting main body 100, and is used for sucking the whole blood sample at the first placement position 5211 on the blood group module 500, and then dripping a first part of the whole blood sample onto the hepatitis b surface antigen detection module 400, so as to determine the nature of the hepatitis b surface antigen.
1-2, The present invention illustrates a preferred embodiment of a mounting body 100, preferably in the form of a mounting bracket, providing mounting locations for modules disposed thereon, including a floor and risers disposed vertically above the floor and separating a main panel 101 from a sub-panel 102, the main panel 101 and sub-panel 102 being mutually perpendicular. The single needle probe mechanism 1000 is capable of moving in both the horizontal and vertical directions of the main panel 101 to effect movement of the single needle probe mechanism 1000, aspiration and titration of whole blood samples.
As shown in fig. 1-2 and 6-7, the present invention provides a preferred embodiment of a single needle probe mechanism 1000, the single needle probe mechanism 1000 comprising a single needle moving body 1101 and a single needle probe body 1102, the single needle moving body 1101 being movably coupled to a main panel 101 of the mounting body 100, the single needle moving body 1101 being adapted to reciprocate along the main panel 101 of the mounting body 100 in a first direction, the single needle probe body 1102 being coupled to the single needle moving body 1101, the single needle probe body 1102 being adapted to reciprocate along the single needle moving body 1101 in a second direction, wherein the first direction and the second direction are horizontal and vertical with respect to each other.
Still further, the single needle moving body 1101 may include a positioning member, a vertical moving mechanism, and a horizontal moving mechanism, wherein the positioning member is connected to the main panel 101 of the mounting body 100 through the horizontal moving mechanism, and the single needle probe body 1102 is connected through the vertical moving mechanism positioning member, alternatively, the horizontal moving mechanism may reciprocate in a belt pulley belt driving manner, and the vertical moving mechanism reciprocates in a belt pulley belt driving manner.
Single needle probe body 1102 preferably includes a second universal ball bearing 1112, a second single needle mount 1122, a second agitation connection 1132, a second agitation motor 1142, a single needle sample reagent probe 1152, and a second hydraulic pump 292; the single-needle sample reagent probe 1152 is connected with the second universal ball bearing 1112, and the second stirring motor 1142 is connected with the second universal ball bearing 1112 through the second stirring connector 1132, the second stirring connector 1132 is connected with the single-needle moving body 1101, and the second stirring motor 1142 drives the single-needle sample reagent probe 1152 to rotate through the second universal ball bearing 1112;
As shown in fig. 2, the single needle probe body 1102 preferably further includes a second plunger pump 1104 and a second two-position three-way solenoid valve 1103; the second plunger pump 1104 and the second two-position three-way electromagnetic valve 1103 are both arranged on one side of the main panel 101 of the mounting main body 100, which is away from the single needle moving main body, the second plunger pump 1104 is connected with a first interface of the second two-position three-way electromagnetic valve 1103, a second interface of the second two-position three-way electromagnetic valve 1103 is connected with the single needle sample reagent probe 1152, and a third interface of the second two-position three-way electromagnetic valve 1103 is used for connecting a purified water pipe.
Wherein the second hydraulic pump 292 includes a fifth diaphragm pump 2921 and a sixth diaphragm pump 2922; the fifth diaphragm pump 2921 is connected to the water inlet pipe of the second probe cleaning tank 1900, and the sixth diaphragm pump 2922 is connected to the water outlet pipe of the second probe cleaning tank 1900.
In the present invention, the hepatitis B surface antigen detection module 400 preferably includes:
Hepatitis B surface antigen reagent strip;
The first camera and the second camera are positioned above the hepatitis B surface antigen reagent strips and used for observing the properties of the whole blood samples on the hepatitis B surface antigen reagent strips, and the hepatitis B surface antigen properties of each blood sample can be stored by photographing the hepatitis B surface antigen properties displayed by the hepatitis B surface antigen reagent strips through the first camera and the second camera on the basis of judging the properties displayed by the hepatitis B surface antigen reagent strips by observing through the cameras, so that the evidence is reserved for the hepatitis B surface antigen properties of each blood sample.
Still include heating mechanism, be located the one end that hepatitis B surface antigen reagent strip is close to installation main part 100, be connected with installation main part 100 for form constant temperature to hepatitis B surface antigen reagent strip, when donation is carried out outdoors through heating mechanism, avoid low temperature in winter to cause the problem that hepatitis B surface antigen reagent strip reaction is slow easily.
Aiming at the problem that the prior art needs to manually drop blood and observe the hepatitis B surface antigen property, the full-automatic blood donation primary screening combined detection device provided by the invention can perform primary combined screening on the blood donated blood sample, and the whole blood sample is sucked by the single-needle probe mechanism 1000 to be titrated to the hepatitis B surface antigen detection module 400, and the hepatitis B surface antigen property in the blood sample is judged by utilizing the hepatitis B surface antigen reagent strip on the hepatitis B surface antigen detection module 400.
In the present invention, the single needle probe mechanism 1000 drops a second portion of whole blood sample into a second placement location 5212 on the blood group module 500 for assisting an operator in determining blood group.
As shown in fig. 1 and 12, the present invention provides a preferred embodiment of a blood group module 500, specifically as follows:
The blood group module 500 is provided with a blood group reagent module 510, a duplex cup module 520 and a third camera; the blood group reagent module 510 is provided with a blood group duplex cup 521 for accommodating a whole blood sample for detection, and a first accommodating position 5211 and a second accommodating position 5212 are formed, wherein the first accommodating position 5211 and the second accommodating position 5212 are respectively used for accommodating a whole blood sample for detection. The third camera of blood group module 500 is located in front of blood group duplex cup 521. Wherein the single needle probe mechanism 1000 can drop a quantitative whole blood sample (second portion of whole blood sample) drawn from the first placement location 5211 into the second placement location 5212. After the single-needle probe mechanism 1000 is moved to the second probe washing pool 1900 to be described below for washing, the single-needle probe mechanism 1000 is moved to the upper end of the first reagent position 511 of the blood group reagent module 510, the first reagent is sucked, the single-needle probe mechanism 1000 is moved to the upper end of the blood group duplex cup 521, the single-needle probe mechanism 1000 is dripped into the first placing position 5211, after the single-needle probe mechanism 1000 is moved to the second probe washing pool 1900 for washing, the second reagent is sucked to the upper end of the second reagent position 512 of the blood group reagent module 510, the second reagent is sucked to the upper end of the blood group duplex cup 521, the single-needle probe mechanism 1000 is dripped into the second placing position 5212, the third camera is used for observing, and then the blood group property of the blood sample can be judged, and the blood group property displayed by the first placing position 5211 and the second placing position 5212 can be photographed and stored through the third camera, wherein, the determination of the surface antigen property of hepatitis B and the blood group can be confirmed on site. The first probe washing tank 900 washes the two-needle sample reagent probe 252 of the two-needle probe mechanism 200, and the second probe washing tank 1900 washes the single-needle sample reagent probe 1152 of the single-needle probe mechanism 1000.
The invention realizes the detection of the hepatitis B surface antigen property and the judgment of the blood type of the blood sample in the primary screening combined detection process, and relieves the technical problems of excessive blood and repeated blood adding detection in the follow-up detection caused by the observation of the hepatitis B surface antigen property and the judgment of the blood type of the blood sample due to the lack of the primary screening combined detection of blood donation in the prior art.
In the present invention, further comprising:
A sample tray mechanism 300 provided on the mounting body 100 and having a centrifuge tube 306;
A double-needle probe mechanism 200 provided on the mounting body 100 and movable in the horizontal and vertical directions of the mounting body 100;
a hemolyzed chyluria module 600;
the single needle probe mechanism 1000 drops a third portion of the whole blood sample drawn into the centrifuge tube 306, and after centrifugation, draws the supernatant through the double needle probe mechanism 200 into the hemolysis chylomicron module 600 for hemolysis and chylomicron detection, such as: the hemolysis chylomicronem module 600 is connected with one end of the double needle moving body 201 far away from the sample tray mechanism 300, the hemolysis chylomicronem module 600 is communicated with the double needle probe body 202, and the double needle probe body 202 is used for conveying the supernatant of the centrifuged blood sample into the hemolysis chylomicronem module 600 for detection.
As shown in fig. 1-5, 8, the present invention provides a specific embodiment of the sample tray mechanism 300, the dual needle probe mechanism 200, and the hemolysis chylomicronemic module 600, as follows:
The sample tray mechanism 300 and the hepatitis b surface antigen detection module 400 are both mounted on the bottom plate of the mounting body 100, and the sample tray mechanism 300 and the hepatitis b surface antigen detection module 400 are located in the same side direction of the main panel 101.
The sample tray mechanism 300 further comprises a turntable 302, a sample rack 304, a centrifuge tube 306, a centrifuge turntable protective cover 319, and a high-speed centrifuge motor 318; carousel 302 rotates with installation main part 100 to be connected, and sample rack 304 is connected with carousel 302, is provided with the storage tank that is used for placing centrifuging tube 306 in the sample rack 304, has placed the hemolytic agent in the centrifuging tube 306, and outside sample dish mechanism 300 was located to centrifugal carousel safety cover 319 cover, provided the protection for sample dish mechanism 300, high-speed centrifugal motor 318 drive carousel 302 rotated and then drove centrifuging tube 306 and realize the centrifugation.
The double-needle probe mechanism 200 includes a double-needle moving body 201 and a double-needle probe body 202, and the double-needle moving body 201 is movably connected to the sub-panel 102 of the mounting body 100, and can move in the horizontal and vertical directions along the sub-panel 102. The method comprises the following steps: the double needle moving body 201 is for horizontally reciprocating along the sub-panel 102 of the mounting body 100, and the double needle probe body 202 is connected to the double needle moving body 201, and the double needle probe body 202 is for vertically reciprocating along the double needle moving body 201.
Further, the dual needle moving body 201 may include a positioning member, a vertical moving mechanism and a horizontal moving mechanism, wherein the positioning member is connected with the sub-panel 102 of the mounting body 100 through the horizontal moving mechanism, and the dual needle probe body 202 is connected through the positioning member of the vertical moving mechanism, alternatively, the horizontal moving mechanism may reciprocate in a manner of driving a belt by a belt pulley, and the vertical moving mechanism drives the dual needle probe body 202 to reciprocate in a manner of driving a belt by a belt pulley.
Still further, the dual needle probe body 202 includes a first universal ball bearing 212, a first single needle mount 222, a first agitation connector 232, a first agitation motor 242, a dual needle sample reagent probe 252, a first water inlet needle 262, a first drain needle 272, and a first hydraulic pump 282; the double-needle sample reagent probe 252 is connected with the first universal ball bearing 212, the first stirring motor 242 is connected with the first universal ball bearing 212 through the first stirring connecting piece 232, the first stirring connecting piece 232 is connected with the double-needle moving body 201, and the first stirring motor 242 drives the double-needle sample reagent probe 252 to rotate through the first universal ball bearing 212; the first single needle holder 222 is connected with the double needle moving body 201, and the first water inlet needle 262 and the first liquid outlet needle 272 are connected with the first double needle holder 211, respectively; the first double needle holder 211 is connected to the double needle moving body 201, the first hydraulic pump 282 is provided in plurality, the plurality of first hydraulic pumps 282 are all connected to the mounting body 100, and the first water inlet needle 262 and the first liquid outlet needle 272 are connected to the first hydraulic pump 282, respectively.
Wherein the first hydraulic pump 282 includes a first diaphragm pump 2821, a second diaphragm pump 2822, a third diaphragm pump 2823, and a fourth diaphragm pump 2824; the first diaphragm pump 2821 is connected to one end of the first water inlet needle 262, the second diaphragm pump 2822 is connected to one end of the first liquid discharge needle 272, the third diaphragm pump 2823 is connected to a first water inlet pipe 902 of a first probe washing tank 900 described below, and the fourth diaphragm pump 2824 is connected to a first water outlet pipe 903 of the first probe washing tank 900 described below.
The double-needle probe main body 202 further comprises a first plunger pump 204 and a second two-position three-way electromagnetic valve 1103; the first plunger pump 204 and the second two-position three-way electromagnetic valve 1103 are both arranged on one side of the auxiliary panel 102 of the mounting main body 100, which is away from the double-needle moving main body 201, the first plunger pump 204 is connected with a first interface of the second two-position three-way electromagnetic valve 1103, a second interface of the second two-position three-way electromagnetic valve 1103 is connected with the other end of the hemolysis chylomicronemia module 600, the opposite end of the hemolysis chylomicronemia module 600 is connected with the double-needle sample reagent probe 252, and a third interface of the second two-position three-way electromagnetic valve 1103 is used for connecting a purified water pipe.
The hemolysis chylomicronemic module 600 is coupled to the dual needle probe body 202, and the first plunger pump 204 is operable to cause the dual needle probe body 202 to absorb a quantity of sample or reagent, and the first plunger pump 204 is configured to ensure that the dual needle sample reagent probe 252 absorbs a more accurate quantity of sample and reagent.
The hemolysis chylomicronemic module 600 comprises a cuvette 601, a hemolysis chylomicronemic detection led light source 602, a photoelectric sensor 603 and a second signal amplification circuit board 604; one end of the colorimetric pool 601 is connected with the double-needle probe main body 202, the opposite end is connected with a second interface of the second two-position three-way electromagnetic valve 1103, a hemolytic chylomicro detection led light source 602 is arranged on the side surface of the colorimetric pool 601, and a photoelectric sensor 603 opposite to the hemolytic chylomicro detection led light source 602 is arranged on the other side surface of the colorimetric pool 601; the second signal amplification circuit board 604 is arranged at the bottom end of the colorimetric pool 601, a light source control circuit and a second signal amplification circuit are arranged in the second signal amplification circuit board 604, and the hemolytic chylomicro detection led light source 602 is connected with the light source control circuit; when the first plunger pump 204 sucks the sample, the hemolyzed chylomicron detection led light source 602 and the photosensor 603 detect the sample in the contrast color cell 601 to obtain a detection result.
In the present invention, further comprising:
A transaminase detection module 800;
After the detection of the hemolytic chylomicronemia module 600 is completed, the dual-needle probe mechanism 200 sucks the transaminase reagent and the mixed sample in the hemolytic chylomicronemia module 600 to inject into the transaminase detection module 800 for transaminase detection. For example, the double needle probe body 202 of the double needle probe mechanism 200 is used to aspirate the transaminase reagent in the transaminase reagent refrigeration module 700 provided on the mounting body 100 to inject the mixed sample of the transaminase reagent and the hemolytic chylomicron module 600 into the transaminase detection module 800 for detection.
As shown in fig. 1 and 9, the present invention provides a preferred embodiment of a transaminase detection module 800, which is specifically as follows:
The transaminase detection module 800 includes a measurement circuit board 801 and four-way test strips 802; four cuvettes 803 and LED light sources 804 are arranged on the four-way detection strip 802, the four cuvettes 803 are sequentially arranged at intervals along the extending direction of the four-way detection strip 802, a photoelectric sensor 603 is correspondingly arranged on the LED light sources 804 of the measurement circuit board 801, and the photoelectric sensor 603 is used for feeding back absorbance information of a mixture in the cuvettes 803 absorbed by the LED light sources 804 to the measurement circuit board 801; each cuvette 803 corresponds to an LED light source 804 and a photoelectric sensor 603, a mixture of a sample and a reagent is put into one cuvette 803 by using the double-needle probe main body 202, the corresponding LED light source 804 and the photoelectric sensor convert the detected result into an electric signal, the electric signal is transmitted to the measurement circuit board 801, and the electric signal is converted into a current or voltage form by the measurement circuit board 801 and is fed back.
An insulating heating pad is arranged between the measurement circuit board 801 and the four-way detection strip 802, a heating area for heating the four-way detection strip 802 is arranged on the measurement circuit board 801, and the heating area is used for heating the four-way detection strip 802; the four-way detection strip 802 is also provided with a temperature sensor, the measurement circuit board 801 is provided with a heating control circuit, and the heating control circuit is electrically connected with the temperature sensor so as to control the temperature of the cuvette 803, so that the cuvette 803 arranged on the four-way detection strip 802 is in a preset range.
In the present invention, the sample tray mechanism 300, the hepatitis B surface antigen detection module 400, the blood group module 500, the transaminase reagent refrigeration module 700, and the transaminase detection module 800 are preferably disposed at a side of the sub-panel 102 of the mounting body 100 in this order with a spacing.
In the present invention, after the transaminase is detected, clear water is poured into the centrifuge tube 306 by the double needle probe mechanism 200, and is mixed with red blood cells by stirring, and then sucked into the hemolysis chylomicronemic module 600 for hemoglobin detection.
In the present invention, further comprising:
and a probe cleaning system provided on the mounting body 100 for cleaning the single-needle probe mechanism 1000 and the double-needle probe mechanism 200.
In the present invention, the probe washing system includes a first probe washing tank 900 and a second probe washing tank 1900 for washing the single-needle probe mechanism 1000 and the double-needle probe mechanism 200, respectively.
As shown in fig. 1, 10-11, the present invention provides a preferred embodiment of a first probe cleaning tank 900 and a second probe cleaning tank 1900, specifically as follows:
The first probe washing tank 900 includes a first main tank body 901, a first water inlet pipe 902 and a first water outlet pipe 903, the first main tank body 901 is connected with the installation main body 100, the first water inlet pipe 902 is disposed near an opening end of the first main tank body 901, and the first water outlet pipe 903 is disposed near a bottom end of the first main tank body 901.
The second probe washing tank 1900 includes a second main tank body 1901, a second water inlet pipe 1902, and a second water outlet pipe 1903, the second main tank body 1901 being connected with the mounting main body 100, the second water inlet pipe 1902 being disposed near an open end of the second main tank body 1901, the second water outlet pipe 1903 being disposed near a bottom end of the second main tank body 1901.
The first probe washing tank 900 and the second probe washing tank 1900 are preferably disposed at the position of the sub-panel 102 and the position of the main panel 101, respectively, and can wash the two-needle probe mechanism 200 and the single-needle probe mechanism 1000 which have sucked blood samples and reagents each time, thereby ensuring the cleaning of the sucking steps of the single-needle probe mechanism 1000 and the two-needle probe mechanism 200, and preventing the mutual influence between the respective detection processes, wherein the cleaning liquid in the first main tank 901 and the second main tank 1901 can be replaced at any time through the first water inlet pipe 902, the second water inlet pipe 1902, the first water outlet pipe 903 and the second water outlet pipe 1903 respectively, and also avoiding the cross influence of the single-needle probe mechanism 1000 and the two-needle probe mechanism 200 in the cleaning process, so that the overall design is more perfect.
The single-needle probe mechanism 1000 moves to the upper end of the second probe washing tank, the single needle of the single-needle probe mechanism 1000 is inserted into the main tank body of the second probe washing tank, the second water inlet pipe 1902 is inserted into the main tank body 1901, the second water outlet pipe 1903 is used for discharging waste water, the cleaning process of the single-needle probe mechanism 1000 is finished, the double-needle probe mechanism 200 moves to the upper end of the first probe washing tank, the single needle of the double-needle probe mechanism 200 is inserted into the main tank body of the first probe washing tank, the first water inlet pipe 902 is inserted into the main tank body 901, the second water inlet pipe 1902 is inserted into the main tank body 1901, the waste water is discharged through the first water outlet pipe 903, and the cleaning process of the double-needle probe mechanism 200 is finished.
The hemolysis chylomicronemic module 600 is connected with the double-needle probe main body 202, the first plunger pump 204 works to enable the double-needle probe main body 202 to absorb a certain amount of sample or reagent, the first plunger pump 204 can ensure that the double-needle sample reagent probe 252 can absorb the amount of the sample and reagent more accurately, the double-needle probe main body 202 needs to enter the first probe cleaning tank 900 for cleaning after being used, the first water inlet pipe 902 and the first water outlet pipe 903 of the first main tank body 901 are respectively connected with the third diaphragm liquid pump 2823 and the fourth diaphragm liquid pump 2824, the third diaphragm liquid pump 2823 and the fourth diaphragm liquid pump 2824 respectively inject liquid into the first main tank body 901 and discharge liquid in the first main tank body 901 so as to clean the double-needle sample reagent probe 252, and when the inner wall of the double-needle sample reagent probe 252 is cleaned, a third interface connected with purified water in the first two-position three-way electromagnetic valve 203 is firstly in an opened state, after the first plunger pump 204 sucks a certain amount of purified water, the third interface of the first two-position three-way electromagnetic valve 203 is closed, a second interface is opened, the first plunger pump 204 works to enable the purified water to be discharged through the double-needle sample reagent probe 252 so as to clean the double-needle sample reagent probe 252, when a cuvette 803 in the double-transaminase detection module 800 is cleaned, the first diaphragm liquid pump 2821 and the second diaphragm liquid pump 2822 work, the first water inlet needle 262 of the double-needle probe mechanism 200 firstly fills water into the cuvette 803, and the first liquid outlet needle 272 discharges water in the cuvette 803 so as to clean the cuvette 803.
The invention provides a use method of a full-automatic blood donation primary screening joint inspection device, which comprises the following steps: the transaminase detection module 800 is started, so that the transaminase detection module 800 reaches a predetermined temperature; Taking 120 mu l of whole blood into a first placement position 5211 of a blood type duplex cup 521, placing the blood type duplex cup 521 into a blood type duplex cup holder 522, sucking 30 mu l of whole blood from the first placement position 5211 by a single needle probe mechanism 1000, dripping the whole blood into a centrifuge tube 306 of a sample tray mechanism 300, which is filled with quantitative hemolytic agent, centrifuging the sample tray mechanism 300 at a high speed for 8-10 seconds, rotating the sample tray mechanism 300 to a fixed position, moving a double needle moving body 201 to the upper end of the sample tray mechanism 300, sucking supernatant from the centrifuge tube 306 by the double needle probe mechanism 200 into a hemolysis chylomicro blood module 600, and after the sample is subjected to hemolysis detection by a colorimetric method, after the sample is subjected to chylomicronemia detection by a turbidimetry method (the hemolysis chylomicronemia detection led light source 602 is a compound lamp capable of emitting light sources with different wavelengths), the double-needle moving body 201 moves to the position above the transaminase reagent refrigerating module 700, the double-needle probe body 202 absorbs reagent, the double-needle moving body 201 moves to the position above the transaminase detecting module 800, the double-needle probe body 202 injects a mixture of the reagent and the blood sample into the transaminase detecting module 800, the double-needle probe body 202 stirs the mixture of the reagent and the blood sample, and the detection is performed by a velocity method for 120 seconds; after the reagent and blood sample are injected into the transaminase detection module 800 by the double-needle probe main body 202, the double-needle moving main body 201 drives the double-needle probe main body 202 to return to the upper part of the sample tray mechanism 300 again, purified water is injected into the centrifuge tube 306 of the sample tray mechanism 300 so as to break red blood cells of the sample in the centrifuge tube 306, the double-needle probe main body 202 can stir the mixture of the purified water and the sample under the action of the first stirring motor 242, then the mixture is kept stand for 40 seconds, sucked into the hemolysis chylomicronemia module 600, and the detection is carried out for 6-10 seconds so as to detect the content of hemoglobin in the sample, and the double-needle probe main body 202 moves to the auxiliary panel 102 to the first probe cleaning pool 900 for cleaning probes. At the same time of the operation of the sample tray mechanism 300, the single needle probe body 1102 sucks the whole blood sample in the first placement position 5211 and drops it onto the hepatitis B surface antigen reagent strip of the hepatitis B surface antigen detection module 400, half of the remaining whole blood drops it into the second placement position 5212, the washing probe is placed in the second probe washing pool 1900 on one side of the main panel 101, the single needle moving body 1101 moves to the upper end of the blood group reagent module 510, the single needle probe body 1102 sucks the A-type reagent in the A-type reagent mechanism on the blood group reagent module 510, moves to the upper end of the first placement position 5211, drops the A-type reagent into the first placement position 5211, And the single needle sample reagent probe 1152 on the single needle probe mechanism 1000 can stir the first placement position 5211 under the action of the second stirring motor 1142, the single needle probe main body 1102 with stirring needs to be moved to the first probe cleaning tank 900 to clean the probe, the single needle moving main body 1101 moves to the upper end of the blood group reagent module 510, the single needle probe main body 1102 sucks the B-type reagent in the B-type reagent mechanism in the blood group reagent module 510, moves to the upper end of the blood group duplex cup, drops the B-type reagent into the second placement position 5212, and the sample reagent probe on the single needle probe mechanism 1000 can stir the second placement position 5212 under the action of the second stirring motor 1142, The probe main body after completing stirring needs to be moved to the first probe cleaning pool 900 to clean the probe, and finally, the property and blood type of the hepatitis B surface antigen are judged through the first camera and the second camera above the hepatitis B surface antigen reagent strip and the third camera in front of the first placing position 5211 and the second placing position 5212; (blood group module 500 is described herein as comprising blood group reagent module 510, blood group duplex cup and blood group duplex cup holder 522, type a reagent, type B reagent being placed in blood group reagent module 510, first placement location 5211, second placement location 5212 being located in blood group duplex cup, blood group duplex cup being placed on blood group duplex cup holder 522, type a reagent, type B reagent reacting with whole blood in first placement location 5211, second placement location 5212, respectively, type a reagent precipitating with whole blood in first placement location 5211, type B reagent precipitating with whole blood in second placement location 5212, type a blood being determined to be type B blood if whole blood in type B and second placement location 5212 does not precipitate, and conversely, If both precipitate, the blood is of type AB and if neither precipitate, the blood is of type O. The second probe cleaning tank 1900 cleans the single needle of the single-needle probe mechanism 1000, and the first probe cleaning tank 900 cleans the single needle of the double-needle probe mechanism 200.
The above is only a preferred embodiment of the present invention; the scope of the invention is not limited in this respect. Any person skilled in the art, within the technical scope of the present disclosure, may apply to the present invention, and the technical solution and the improvement thereof are all covered by the protection scope of the present invention.
Claims (9)
1. The full-automatic blood donation primary screening combined detection device is characterized by comprising a mounting main body, a single needle probe mechanism, a blood type module and a hepatitis B surface antigen detection module, wherein the single needle probe mechanism, the blood type module and the hepatitis B surface antigen detection module are arranged on the mounting main body;
The single needle probe mechanism can move along the horizontal direction and the vertical direction of the mounting main body and is used for dripping a first part of whole blood sample onto the hepatitis B surface antigen detection module after sucking the whole blood sample at a first position on the blood type module and judging the nature of hepatitis B surface antigens;
Further comprises:
a sample tray mechanism disposed on the mounting body, the sample tray mechanism having a centrifuge tube;
a double-needle probe mechanism provided on the mounting main body and movable in the horizontal and vertical directions of the mounting main body;
a hemolyzed chyluria module;
And the single-needle probe mechanism drops a third part of the sucked whole blood sample into the centrifuge tube, and after centrifugation, the double-needle probe mechanism sucks supernatant into the hemolysis chylomicron module for hemolysis and chylomicron detection.
2. The fully automated primary blood donation screening apparatus according to claim 1, wherein the single needle probe mechanism drops a second portion of whole blood sample into a second location on the blood group module for assisting a worker in determining blood group.
3. The fully automated primary blood donation screening apparatus according to claim 1, further comprising:
a transaminase detection module;
After the detection of the hemolytic chylomicronemic module is completed, the double-needle probe mechanism absorbs the transaminase reagent and the mixed sample in the hemolytic chylomicronemic module, and the mixed sample is injected into the transaminase detection module to carry out transaminase detection.
4. A fully automatic blood donation primary screening device according to claim 3, wherein after the transaminase is detected, clear water is spitted into the centrifuge tube through the double needle probe mechanism, and after the clear water and red blood cells are stirred and mixed, the clear water is sucked into the hemolysis chylomicron module for hemoglobin detection.
5. The fully automated primary blood donation screening apparatus according to claim 1, further comprising:
and the probe cleaning system is arranged on the mounting main body and is used for cleaning the single-needle probe mechanism and the double-needle probe mechanism.
6. The fully automated blood donation screening kit according to claim 5, wherein the probe washing system includes first and second probe washing tanks for washing the single and double probe mechanisms, respectively.
7. The fully automated primary blood donation screening assay device of claim 1, wherein the hepatitis b surface antigen detection module includes:
Hepatitis B surface antigen reagent strip;
The first camera and the second camera are positioned above the hepatitis B surface antigen reagent strip and used for observing the properties of the whole blood sample on the hepatitis B surface antigen reagent strip.
8. The fully automated primary blood donation screening apparatus according to claim 1, wherein the blood group module includes:
The blood group reagent module is used for placing a plurality of reagents;
a duplex cup module having a blood group duplex cup for placing a whole blood sample for testing;
the first placing position and the second placing position are arranged on the blood group duplex cup.
9. The fully automatic blood donation primary screening apparatus according to any one of claims 1-8, wherein the mounting body includes a base plate and a riser disposed on the base plate;
the vertical plate comprises a main panel and an auxiliary panel which are mutually perpendicular and are arranged on the bottom plate;
The single-needle probe mechanism is arranged on the main panel and can move along the main panel in the horizontal and vertical directions.
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| CN202411306430.6A CN118962160A (en) | 2024-09-19 | 2024-09-19 | A fully automatic blood donation screening and joint testing device |
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| JP2014115150A (en) * | 2012-12-07 | 2014-06-26 | Kagawa Univ | Automatic analyzer, blood typing inspection reagent, and aggregate hemolyzing reagent |
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