CN118845957A - A hangover-relieving composition and preparation method thereof - Google Patents

Abstract

The invention discloses an anti-alcohol composition and a preparation method thereof, wherein the anti-alcohol composition is prepared from the following raw materials in parts by weight: 10-40 parts of semen hoveniae, 10-40 parts of kudzuvine root, 15-35 parts of pilose asiabell root, 15-35 parts of stir-fried largehead atractylodes rhizome, 15-45 parts of Indian buead, 8-35 parts of raw liquorice, 10-30 parts of dried orange peel, 10-30 parts of hawthorn, 10-30 parts of stir-fried malt, 15-45 parts of lily and 10-30 parts of red sage root. The preparation method comprises the following steps: s1, cleaning raw materials; s2, grinding; s3, mixing; s4, preparing. The composition is prepared from pure traditional Chinese medicines and pure natural plants, has no toxic or side effect on human bodies, achieves the effects of relieving alcoholism, maintaining organs such as kidneys and livers, reducing blood fat, reducing serum cholesterol and triacylglycerols, and greatly reducing the damage of alcohol to human bodies.

Description

A hangover-relieving composition and preparation method thereof

Technical Field

The invention relates to the technical field of health care products, in particular to a hangover-relieving composition and a preparation method thereof.

Background Art

Excessive drinking can not only cause liver damage and corresponding liver lesions, but also trigger other diseases, and in severe cases, can cause physiological dysfunction and even death. Alcoholic liver damage caused by excessive drinking has become one of the main factors for liver disease. At the same time, excessive drinking often leads to hypertension, gastric cancer and other malignant diseases, and metabolic disorders of substances such as proteins. The most common poison that causes liver damage is alcohol, and liver damage caused by excessive drinking has become a global medical problem. Therefore, the need for how to sober up, relieve alcohol and reduce the damage to the gastrointestinal tract, liver and other organs of the human body caused by drinking is imminent, and the development of effective alcohol-relieving drugs is of great significance and has broad market prospects.

In recent years, there have been many reports and products of medical health foods, beverages and drugs for sobering up, such as patent application No. CN 1058907A for "sobering up and protecting liver oral liquid" prepared with bitter orange seeds, schisandra chinensis and kudzu root; patent application No. CN1238036C for "a pure natural sobering up and protecting liver granule" prepared with kudzu root, bitter orange seeds, tangerine peel, mountain slag, corn silk and poria.

However, the effects of hangover products with different formulas vary greatly. Moreover, although there are various hangover products on the market, they are of little efficacy and poor results. However, most products have disadvantages such as many indications, a wide range of treatments, unclear efficacy, and weak targeting. Moreover, many products are only effective in preventing drunkenness, but not effective after being drunk; or they only focus on protecting the liver, but have no rapid and obvious improvement effect on the high blood alcohol concentration after drinking.

And the current hangover medicine generally uses the decomposition of alcohol to play the role of hangover, and the hangover effect is slow, and can only alleviate the symptoms of human discomfort caused by the high alcohol concentration in the human body, but has no health care effect on the liver and kidney damage caused by alcohol. After alcohol is metabolized in the liver, harmful metabolites such as acetaldehyde will be produced. If the metabolism and excretion of acetaldehyde are not accelerated, more serious kidney damage will be caused. In order to improve the hangover effect, existing hangover medicines are often added with chemical additives to improve the hangover effect of hangover medicines. Chemical additives are generally metabolized by the liver and excreted by the kidneys. Long-term consumption of food with a large amount of chemical additives is not through long-term pharmacology, toxicology, clinical trials, and the combination of Chinese and Western medicines, which easily brings potential safety hazards.

Therefore, a hangover-relieving composition and a preparation method thereof are proposed to solve the current deficiencies.

Summary of the invention

The technical problem to be solved by the present invention is to overcome the defects of the above-mentioned technology and provide a hangover-relieving composition and a preparation method thereof.

To solve the above technical problems, the technical solution provided by the present invention is a hangover-relieving composition and a preparation method thereof, which is made from the following raw materials in weight ratio: 10-40 parts of Hovenia dulcis, 10-40 parts of Pueraria root, 15-35 parts of Codonopsis pilosula, 15-35 parts of stir-fried Atractylodes macrocephala, 15-45 parts of Poria cocos, 8-35 parts of raw licorice, 10-30 parts of dried tangerine peel, 10-30 parts of hawthorn, 10-30 parts of stir-fried malt, 15-45 parts of lily, and 10-30 parts of Salvia miltiorrhiza.

As an improvement, it is made from the following raw materials in the following weight ratio: 25 parts of Hovenia dulcis, 25 parts of Pueraria root, 27 parts of Codonopsis pilosula, 27 parts of stir-fried Atractylodes macrocephala, 30 parts of Poria cocos, 21 parts of raw licorice, 20 parts of dried tangerine peel, 20 parts of hawthorn, 20 parts of stir-fried malt, 30 parts of lily, and 20 parts of Salvia miltiorrhiza.

A method for preparing a hangover-relieving composition comprises the following steps:

S1. Raw material cleaning: weigh the above raw materials according to the above mass fractions, remove impurities, rinse with clean water, and then drain for later use;

S2, grinding: grinding the washed drugs into fine powder respectively, passing through a 100-mesh sieve, and collecting for later use;

S3, mixing: putting the ground medicine into a stirring container and stirring evenly to obtain medicine powder;

S4. Preparation: Processing the mixed powder and a pharmaceutically acceptable carrier into a shape to obtain a composition.

The present invention also provides a hangover-relieving composition, which comprises the above composition or other pharmaceutically acceptable physical forms.

As an improvement, the composition is in the form of tablets, oral liquid, capsules, granules or pills.

As an improvement, the present invention also provides the use of the above-mentioned drug in preparing a composition capable of sobering up.

The pharmacological properties of the Chinese medicinal materials used are as follows:

Hovenia dulcis: sweet, neutral in nature, enters the stomach meridian; has the effects of clearing heat, promoting diuresis, and detoxifying alcohol; the large amount of glucose and organic acids contained in it can not only expand the blood volume of the human body, but also detoxify alcohol, and has the effect of sobering up and calming the mind. Modern research has found that Hovenia dulcis can significantly reduce the concentration of ethanol in the blood and promote the removal of ethanol.

At the same time, Hovenia dulcis contains active ingredients such as saponins, flavonoids and alkaloids, which can prevent and treat acute alcohol poisoning and protect the gastric mucosa. The content of dihydromyricetin in flavonoids is relatively high, which has antibacterial, blood sugar and blood lipid regulation, liver protection, antioxidant and anti-tumor effects.

Pueraria root: sweet, spicy, cool in nature; dilates blood vessels, improves blood circulation; reduces myocardial oxygen consumption, inhibits cancer cells; increases coronary flow, regulates blood microcirculation; treats sudden deafness at all ages; reduces the risk of cardiovascular and cerebrovascular diseases, prevents and treats cardiovascular diseases, regulates blood sugar and blood lipids, maintains circulatory health, and regulates menopausal symptoms;

Codonopsis: sweet in taste, neutral in nature; enters the spleen and lung meridians; sweet and tonic but neutral, tonifies the middle and replenishes Qi, harmonizes the stomach and regulates the middle, is neither dry nor greasy, and is used to treat spleen and lung Qi deficiency, improve conditions such as loss of appetite, fatigue, cough, weak asthma, sallow complexion, and weakness in the limbs.

Among them, flavonoids, alkaloids, sugars, saponins, steroids, amino acids and others are the main active ingredients, which have a certain regulatory effect on the gastrointestinal tract, achieve the effect of soothing the stomach and protecting the liver, and also have anti-inflammatory function.

Stir-fried Atractylodes macrocephala: Stir-fried Atractylodes macrocephala is a processed product of Atractylodes macrocephala, which is the dried rhizome of Atractylodes macrocephala of the Asteraceae family. Stir-fried Atractylodes macrocephala is sweet, warm and nourishing, bitter and dehumidifying, and mainly enters the spleen and stomach meridians. It is used for spleen deficiency, poor appetite, abdominal distension and diarrhea, phlegm and fluid, dizziness and palpitations, edema, spontaneous sweating, and fetal movement disorder. It has the effects of strengthening the spleen and replenishing qi, drying dampness and promoting diuresis, stopping sweating, and enhancing cellular immunity. It also has the effects of diuresis, liver protection, anti-tumor, gallbladder, hypoglycemic, antibacterial, antitussive, and sedative.

Poria: sweet, light, neutral in nature; enters the heart, lung, spleen, and kidney meridians; has the effects of promoting diuresis and removing dampness, strengthening the spleen, and calming the mind; used for urinary incontinence, edema, phlegm and cough, vomiting, spleen deficiency, poor appetite, diarrhea, palpitations, insomnia, forgetfulness, and leukorrhea;

Raw licorice: sweet, neutral in nature; enters the heart, lung, spleen, and stomach meridians; has the effects of tonifying the spleen and replenishing qi, clearing away heat and detoxifying, removing phlegm and relieving cough, relieving urgency and relieving pain, and harmonizing various medicines; used for spleen and stomach weakness, fatigue, palpitations and shortness of breath, cough with sputum, abdominal and limb cramps and pain, carbuncle, sore and ulcer, and relieves drug toxicity and potency;

Tangerine peel: bitter, pungent, warm in nature; enters the lung and spleen meridians; has the effects of regulating qi and strengthening the spleen, drying dampness and resolving phlegm; used for abdominal distension, loss of appetite, vomiting and diarrhea, and cough with excessive phlegm;

Tangerine peel contains volatile oil, hesperidin, vitamin B, C and other ingredients. The volatile oil it contains has a mild stimulating effect on the gastrointestinal tract, which can promote the secretion of digestive juices, eliminate gas accumulation in the intestines, and increase appetite. Tangerine peel is also a commonly used Chinese medicine, which has the effects of ventilating the spleen, drying dampness and resolving phlegm, relieving greasiness and leaving fragrance, and relieving nausea and vomiting.

Hawthorn: tastes sour and sweet, slightly warm in nature, and non-toxic; it enters the spleen, stomach, liver, and lung meridians; it can eliminate food accumulation and resolve stagnation and blood stasis; it is mainly used to treat food stagnation, abdominal distension and pain, diarrhea and dysentery, blood stasis and dysmenorrhea, amenorrhea, postpartum abdominal pain, and lochia retention.

Hawthorn tastes sour and sweet, and enters the spleen, stomach, and liver meridians; it has the effect of strengthening the spleen and digesting food. Hawthorn has significant clinical efficacy and also has pharmacological activities such as anti-tumor, anti-inflammatory, analgesic, antibacterial, improving immunity, lowering blood sugar, and regulating blood lipids.

Roasted malt: Digestive effect: Malt decoction seems to have a mild promoting effect on the secretion of gastric acid and pepsin; it can promote the secretion of human digestive juices and accelerate the conversion of alcohol in the body;

Lily: sweet in taste, slightly cold in nature; enters the lung, heart, and stomach meridians. It has the effect of clearing the heart and relieving restlessness, calming the mind and calming the nerves, and can eliminate the confusion, depression, and irritability caused by acute alcohol poisoning;

Danshen: bitter, slightly cold; enters the heart and liver meridians; has the effects of promoting blood circulation and removing blood stasis, relieving pain from menstruation, clearing the heart and eliminating vexation, cooling blood and eliminating carbuncle; used for chest pain, abdominal and rib pain, accumulation of masses, heat arthralgia, insomnia, irregular menstruation, dysmenorrhea, amenorrhea, sores and swelling; contains quinones, protocatechuic aldehyde, protocatechuic acid, lactic acid, vitamin E and other ingredients, has the functions of promoting blood circulation and removing blood stasis, relieving pain from menstruation, clearing the heart and eliminating vexation, cooling blood and eliminating carbuncle;

Compared with the prior art, the advantages of the present invention are as follows: Hovenia dulcis contains a large amount of glucose and organic acid, which can not only expand the blood volume of the human body, but also detoxify alcohol, and contains a large amount of glucose, organic salts, and lipid substances, which have the effects of promoting urine excretion, accelerating intestinal peristalsis, etc.; Pueraria root extract mainly contains carbohydrates, plant protein, multiple vitamins and minerals, and also contains flavonoids. People who often drink and smoke, and those who are poisoned by alcohol metabolism can take Pueraria root extract to prevent hepatitis, improve the liver's detoxification function, and repair damaged liver cells. Hovenia dulcis and Poria cocos promote alcohol excretion; Pueraria root strengthens the liver and detoxifies; Codonopsis pilosula can protect the liver, while Codonopsis pilosula and Poria cocos can strengthen the spleen and transport dampness, promote the movement of qi in the middle burner, while Atractylodes macrocephala can strengthen the body and replenish qi and nourish the stomach; Tangerine peel volatile oil contains limonene, γ-terpinene and other ingredients, which have the effects of relieving asthma, resolving phlegm, and relieving cough; Lily has the effects of invigorating qi and tonifying the middle, invigorating the lungs and relieving cough, and the colchicine it contains has the effect of resisting liver fibrosis and cirrhosis, and has a good liver protection effect; Hawthorn polyphenols in Hawthorn help neutralize alcohol, promote human enzyme activity, and accelerate the metabolism of alcohol in the blood, thereby playing a role in sobering up, protecting the liver, and relieving alcohol The ingredients in salvia miltiorrhiza can promote blood circulation, increase blood supply and oxygen delivery to various parts of the body, which helps to relieve fatigue and restore physical strength. At the same time, it is rich in antioxidants, which can help to remove free radicals and reduce the damage of oxidative stress to the liver and other organs; licorice has the effect of harmonizing the medicinal properties. Similarly, the composition is made of pure Chinese medicine and the raw materials are all made of pure natural plants. It has no toxic side effects on the human body. While achieving the effect of sobering up, it can also maintain organs such as the kidney and liver, as well as lower blood lipids, reduce serum cholesterol and triglycerides, and treat alcoholic liver, greatly reducing the damage of alcohol to the human body.

DETAILED DESCRIPTION

The content of the present invention can be more easily understood by selecting the following detailed description of the preferred implementation method of the present invention and the embodiments included. Unless otherwise specified, all technical and scientific terms used herein have the same meanings as those of ordinary skill in the art to which the present invention belongs. When there is a conflict, the definition in this specification shall prevail.

As used herein, the term "prepared from" is synonymous with "comprising." As used herein, the terms "comprising," "including," "having," "containing," or any other variation thereof, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises the listed elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.

The conjunction "consisting of excludes any unspecified element, step, or component. If used in a claim, this phrase renders the claim closed-ended so that it does not include materials other than those described, except for conventional impurities associated therewith. When the phrase "consisting of" appears in a clause of the body of a claim rather than immediately following the subject matter, it limits only the elements described in that clause; other elements are not excluded from the claim as a whole.

When amount, concentration or other value or parameter is expressed as range, preferred range or a series of upper preferred value and lower preferred value limit range, this should be understood as specifically disclosing all ranges formed by any pairing of any range upper limit or preferred value and any range lower limit or preferred value, regardless of whether the range is disclosed separately. For example, when disclosing range "1 to 5", described range should be interpreted as including range "1 to 4", "1 to 3", "1 to 2", "1 to 2 and 4 to 5", "1 to 3 and 5" etc. When numerical range is described in this article, unless otherwise stated, the range is intended to include its end value and all integers and fractions within the range.

Singular forms include plural references unless the context clearly indicates otherwise. "Optional" or "either" means that the subsequently described event or incident may or may not occur, and that the description includes instances where the event occurs and instances where it does not.

Approximate terms in the specification and claims are used to modify quantities, indicating that the present invention is not limited to the specific quantity, but also includes acceptable and modified parts close to the quantity without causing changes in the relevant basic functions. Accordingly, the use of "about", "approximately", etc. to modify a numerical value means that the present invention is not limited to the exact numerical value. In some examples, the approximate terms may correspond to the accuracy of the instrument for measuring the numerical value. In the specification and claims of this application, range limitations can be combined and/or interchanged, and if not otherwise stated, these ranges include all subranges contained therein.

In addition, the indefinite articles "a" and "an" before the elements or components of the present invention have no restrictions on the quantity requirements (i.e. the number of occurrences) of the elements or components. Therefore, "a" or "an" should be interpreted as including one or at least one, and the elements or components in the singular form also include the plural form, unless the number is obviously intended to be in the singular form.

"Polymer" means a polymeric compound prepared by polymerizing monomers of the same or different types. The general term "polymer" includes the terms "homopolymer", "copolymer", "terpolymer" and "interpolymer". "Interpolymer" means a polymer prepared by polymerizing at least two different monomers. The general term "interpolymer" includes the term "copolymer" (which is generally used to refer to a polymer prepared from two different monomers) and the term "terpolymer" (which is generally used to refer to a polymer prepared from three different monomers). It also includes polymers made by polymerizing more monomers. "Blend" means a polymer formed by mixing two or more polymers together by physical or chemical methods.

In addition, any methods and materials similar or equivalent to those described herein can be applied to the present invention. The preferred implementation methods and materials described herein are for demonstration purposes only and cannot limit the content of this application.

The experimental methods in the following examples are conventional methods unless otherwise specified; the experimental materials and test strains used in the following examples are purchased from commercial channels unless otherwise specified.

Embodiment 1

A hangover-relief composition and a preparation method thereof are prepared from the following raw materials in weight proportion: 10 parts of Hovenia dulcis, 10 parts of Pueraria root, 15 parts of Codonopsis pilosula, 15-35 parts of stir-fried Atractylodes macrocephala, 15 parts of Poria cocos, 8 parts of raw liquorice, 10 parts of dried tangerine peel, 10 parts of hawthorn, 10 parts of stir-fried malt, 15 parts of lily and 10 parts of Salvia miltiorrhiza.

A method for preparing a hangover-relieving composition comprises the following steps:

S1. Raw material cleaning: weigh the above raw materials according to the above mass fractions, remove impurities, rinse with clean water, and then drain for later use;

S2, grinding: grinding the washed drugs into fine powder respectively, passing through a 100-mesh sieve, and collecting for later use;

S3, mixing: putting the ground medicine into a stirring container and stirring evenly to obtain medicine powder;

S4. Preparation: Processing the mixed powder and a pharmaceutically acceptable carrier into a shape to obtain a composition.

The present invention also provides a hangover-relieving composition, which comprises the above composition or other pharmaceutically acceptable physical forms.

Furthermore, the composition is in the form of tablets, oral liquid, capsules, granules or pills.

Furthermore, the present invention also provides the use of the above-mentioned drug in preparing a composition capable of sobering up.

Embodiment 2

A hangover-relief composition and a preparation method thereof are prepared from the following raw materials in weight proportion: 25 parts of Hovenia dulcis, 25 parts of Pueraria root, 27 parts of Codonopsis pilosula, 27 parts of stir-fried Atractylodes macrocephala, 30 parts of Poria cocos, 21 parts of raw liquorice, 20 parts of dried tangerine peel, 20 parts of hawthorn, 20 parts of stir-fried malt, 30 parts of lily and 20 parts of Salvia miltiorrhiza.

A method for preparing a hangover-relieving composition comprises the following steps:

S1. Raw material cleaning: weigh the above raw materials according to the above mass fractions, remove impurities, rinse with clean water, and then drain for later use;

S2, grinding: grinding the washed drugs into fine powder respectively, passing through a 100-mesh sieve, and collecting for later use;

S3, mixing: putting the ground medicine into a stirring container and stirring evenly to obtain medicine powder;

S4. Preparation: Processing the mixed powder and a pharmaceutically acceptable carrier into a shape to obtain a composition.

The present invention also provides a hangover-relieving composition, which comprises the above composition or other pharmaceutically acceptable physical forms.

Furthermore, the composition is in the form of tablets, oral liquid, capsules, granules or pills.

Furthermore, the present invention also provides the use of the above-mentioned drug in preparing a composition capable of sobering up.

Embodiment 3

A hangover-relief composition and a preparation method thereof are prepared from the following raw materials in weight proportion: 40 parts of Hovenia dulcis, 40 parts of Pueraria root, 35 parts of Codonopsis pilosula, 35 parts of stir-fried Atractylodes macrocephala, 45 parts of Poria cocos, 35 parts of raw liquorice, 30 parts of dried tangerine peel, 30 parts of hawthorn, 30 parts of stir-fried malt, 45 parts of lily and 30 parts of Salvia miltiorrhiza.

A method for preparing a hangover-relieving composition comprises the following steps:

S1. Raw material cleaning: weigh the above raw materials according to the above mass fractions, remove impurities, rinse with clean water, and then drain for later use;

S2, grinding: grinding the washed drugs into fine powder respectively, passing through a 100-mesh sieve, and collecting for later use;

S3, mixing: putting the ground medicine into a stirring container and stirring evenly to obtain medicine powder;

S4. Preparation: Processing the mixed powder and a pharmaceutically acceptable carrier into a shape to obtain a composition.

The present invention also provides a hangover-relieving composition, which comprises the above composition or other pharmaceutically acceptable physical forms.

Furthermore, the composition is in the form of tablets, oral liquid, capsules, granules or pills.

Furthermore, the present invention also provides the use of the above-mentioned drug in preparing a composition capable of sobering up.

Comparative Example 1

This comparative example provides a hangover-relieving composition, which differs from Example 2 only in that all components do not contain Codonopsis pilosula and Atractylodes macrocephala, and the remaining components and component contents are the same as those in Example 2.

Comparative Example 2

This comparative example provides a hangover-relieving composition, which differs from Example 2 only in that all components do not contain Poria cocos and raw liquorice, and the remaining components and component contents are the same as those in Example 2.

Comparative Example 3

This comparative example provides a hangover-relieving composition, which differs from Example 2 only in that all components do not contain dried tangerine peel and salvia miltiorrhiza, and the remaining components and component contents are the same as those in Example 2.

In order to better illustrate the technical effect of the present invention, the following experiment was conducted.

Experimental Example 1: Test on the effect of the Chinese medicine composition on the sobering time of drunk mice.

1. Experimental Materials

(1) Test samples: samples prepared in Example 2 and Comparative Examples 1 to 3.

(2) Experimental animals: healthy ICR mice, SPF grade, weight 22±3 g, half male and half female. After one week of adaptive feeding, the mice were randomly divided into 6 groups, namely blank control group, model control group, Example 2 group, comparative example 1 group, comparative example 2 group, and comparative example 3 group, with 10 mice in each group.

(3) Animal grouping and treatment: Before the experiment, mice were deprived of water and food. During the experiment, mice in each group were gavaged with 56° Red Star Erguotou liquor at a dose of 0.2 ml/10 g. The blank control group was not treated; the model control group was gavaged with distilled water at a dose of 0.15 ml/10 g; the composition used in Example 2 group was the composition prepared according to the method of Example 2, and the composition solution of 0.2 g/ml was gavaged at a dose of 0.15 ml/10 g; the composition used in Comparative Example 1 group was the composition prepared according to the method of Comparative Example 1, and the composition solution of 0.2 g/ml was gavaged at a dose of 0.15 ml/10 g; the composition used in Comparative Example 2 group was the composition prepared according to the method of Comparative Example 2, and the composition solution of 0.2 g/ml was gavaged at a dose of 0.15 ml/10 g; the composition used in Comparative Example 3 group was the composition prepared according to the method of Comparative Example 3, and the composition solution of 0.2 g/ml was gavaged at a dose of 0.15 ml/10 g.

During implementation, the timing started after the administration of liquor, and the death, vomiting, fatigue and other symptoms of the mice during the administration period were observed and recorded. The disappearance and recovery time of the righting reflex of the mice were recorded, and the drunkenness rate and drunkenness maintenance time of the mice were calculated (the mice were gently turned over so that they were in a supine position, and those that could not right themselves within 30 seconds were considered drunk).

The righting reflex was used as an indicator to observe the soberness of mice. The specific drunkenness conditions are shown in Table 1.

As can be seen from Table 1, compared with the blank control group and the model control group, after the mice in the Example 2 group and the comparative example groups were gavaged with liquor, the Example 2 group and the comparative example groups could effectively shorten the duration of drunkenness, and had obvious sobering effect, among which the comparative example group had similar effect, while the Example 2 group had significantly better effect than other groups, and the sobering time was the shortest. This indicates that the composition has a good sobering effect on experimental animals, can effectively shorten the duration of drunkenness, and the various Chinese medicinal ingredients in the composition are reasonably matched according to the principle of Chinese medicine dialectical treatment, the various medicinal materials interact with each other, and have synergistic effects, the lack of some medicinal materials in the formula cannot achieve a good sobering effect on mice, and the sobering effect of the composition of the present invention on mice is also significantly better than other compositions.

Experimental Example 2: Test on the effect of the Chinese medicine composition on mice with alcoholic liver damage.

(1) Test samples: samples prepared in Example 2 and Comparative Examples 1 to 3.

(2) Experimental animals: healthy ICR mice, SPF grade, weight 22±3 g, half male and half female. After one week of adaptive feeding, the mice were randomly divided into 6 groups, namely blank control group, model control group, Example 2 group, comparative example 1 group, comparative example 2 group, and comparative example 3 group, with 10 mice in each group.

(3) Animal grouping and treatment: The mice were fasted and deprived of water the night before the experiment. During the experiment, except for the blank control group, the mice were gavaged with an equal volume of distilled water every day; the model control group, the Example 2 group and each comparative example group were gavaged with 56° Red Star Erguotou liquor at a dose of 0.2 ml/10 g, and then the model control group was gavaged with distilled water at a dose of 0.15 ml/10 g; the Example 2 group was gavaged with a composition prepared according to the method of Example 2 at a dose of 0.2 g/ml; the comparative example group was gavaged with a composition prepared according to the method of Comparative Example 1. The composition prepared by the method of comparative example 2 was administered intragastrically with a 0.2 g/ml solution of the composition at 0.15 ml/10 g; the composition used in comparative example group 2 was prepared by the method of comparative example 2, and was administered intragastrically with a 0.2 g/ml solution of the composition at 0.15 ml/10 g; the composition used in comparative example group 3 was prepared by the method of comparative example 3, and was administered intragastrically with a 0.2 g/ml solution of the composition at 0.15 ml/10 g. The drugs were administered continuously for 7 days, and the mice were fasted but not watered after the last oral gavage. Blood samples and liver tissues of mice in each group were taken for index detection 12 hours later.

The test results of serum biochemical indexes in each group are shown in Table 2.

As can be seen from Table 2, compared with the blank control group, the ALT and ASL activities in the model control group were significantly increased, indicating liver cell damage. Compared with the model control group, the embodiment group and the ratio groups, the serum indexes ALT and AST in the blank control group were significantly lower than those in the model control group, indicating that the liver of mice had been damaged after long-term intragastric administration of high alcohol.

Compared with the blank control group and the model control group, the contents of ALT and AST in the embodiment group and each ratio group were higher than those in the blank control group, but lower than those in the model control group, and were between the model control group and the blank control group. In addition, the data parameters of the embodiment group and each ratio group had significant differences.

It can be seen that the composition of the present invention can significantly reduce the content of AST and ALT in the serum liver tissue of mice caused by ethanol, has a significant inhibitory effect on liver damage caused by drinking, has a good protective effect on liver damage after drinking and can reduce liver damage. At the same time, according to the detection data of the second embodiment group and each comparative example group, when any component medicinal material in the formula of the composition of the present invention is reduced, the liver protection effect of the obtained composition is significantly reduced, which further verifies the synergistic enhancement effect between the raw material components of the composition.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

The present invention and its implementation methods are described above, but such description is not restrictive, and what is shown is only one of the implementation methods of the present invention, and the actual structure is not limited thereto. In short, if ordinary technicians in the field are inspired by it, without departing from the purpose of the invention, they can design a structure and embodiment similar to the technical solution without creativity, which should belong to the protection scope of the present invention.

Claims (6)

1. A hangover-relieving composition, characterized in that it is made from the following raw materials in weight ratio: 10-40 parts of Hovenia dulcis, 10-40 parts of Pueraria root, 15-35 parts of Codonopsis pilosula, 15-35 parts of stir-fried Atractylodes macrocephala, 15-45 parts of Poria cocos, 8-35 parts of raw licorice, 10-30 parts of dried tangerine peel, 10-30 parts of hawthorn, 10-30 parts of stir-fried malt, 15-45 parts of lily, and 10-30 parts of Salvia miltiorrhiza. 2. A hangover-relieving composition according to claim 1, characterized in that it is made from the following raw materials in weight ratio: 25 parts of Hovenia dulcis, 25 parts of Pueraria root, 27 parts of Codonopsis pilosula, 27 parts of stir-fried Atractylodes macrocephala, 30 parts of Poria cocos, 21 parts of raw liquorice, 20 parts of dried tangerine peel, 20 parts of hawthorn, 20 parts of stir-fried malt, 30 parts of lily, and 20 parts of Salvia miltiorrhiza. 3. A method for preparing a hangover-relieving composition, characterized in that it comprises the following steps: S1. Raw material cleaning: weigh the above raw materials according to the above mass fractions, remove impurities, rinse with clean water, and then drain for later use; S2, grinding: grinding the washed drugs into fine powder respectively, passing through a 100-mesh sieve, and collecting for later use; S3, mixing: putting the ground medicine into a stirring container and stirring evenly to obtain medicine powder; S4. Preparation: Processing the mixed powder and a pharmaceutically acceptable carrier into a shape to obtain a composition. 4. A hangover-relieving composition, comprising the composition according to any one of claims 1-2 or the composition obtained by the preparation method according to claims 3-4 or other pharmaceutically acceptable physical forms. 5. The composition according to claim 4, characterized in that the composition is in the form of tablets, oral liquids, capsules, granules or pills. 6. Use of the composition according to any one of claims 1 to 2 or the composition obtained by the preparation method according to claims 3 to 4 in preparing a composition capable of sobering up.