CN118743817B - A rumen continuous drug delivery system - Google Patents

Abstract

The invention provides a rumen sustained drug delivery system which comprises a sustained release cabin main body, an end cover and wings, wherein the sustained release cabin main body is provided with a prismatic outer wall and a cylindrical inner wall, a first end of the sustained release cabin main body is open, a spring and a plunger are arranged in the first end of the sustained release cabin main body, the end cover is combined with the first end of the sustained release cabin main body, the end cover is provided with an opening, the wings are arranged at a second end of the sustained release cabin main body and extend along the radial direction of the sustained release cabin main body, the wings can be bent to be attached to the outer wall of the sustained release cabin main body, a plurality of fish scale grooves are arranged at two sides of the wings, and the fish scale grooves penetrate through the thickness of the wings and are arranged at positions at two sides of the wings in a staggered manner. The rumen slow release bin provided by the invention increases the overall hydrodynamic performance of the slow release bin, avoids forage winding, and enhances the effectiveness and practicality.

Description

Rumen continuous drug delivery system

Technical Field

The invention relates to the fields of livestock and animal medicine, in particular to a rumen continuous drug delivery system.

Background

With the progress of modern agriculture, intensive pastures are rapidly developed. Intensive pastures pay attention to technological investment and technical innovation, and pay attention to improvement of breeding efficiency and quality, so that cow breeding is more scientific and efficient.

In the production and application of cows, long-acting and continuous administration strategies are often implemented for key drugs such as anthelmintics, antibiotics, vitamins, plant extracts, trace elements and the like in order to ensure the health and production benefits of the cows. Particularly in intensive pastures, the animals are large in number and complex to manage, and the long-acting slow release preparation can continuously release medicines in a preset longer time, so that the administration process can be simplified, the management efficiency can be improved, and meanwhile, the health and the production performance of the animals can be ensured. This means that animals in the intensive pasture do not need frequent administration, and the administration times and labor cost are reduced, so that the management of the intensive pasture is more convenient and efficient, and the economic benefit of the intensive pasture is improved. There is also a long-term, sustained need for pharmaceutical use in grazing animals.

The sustained release preparation refers to a preparation which can continuously release the drug for a long time after administration to achieve a long-acting effect, can release the drug at a certain part of animal body, effectively regulate and control the release speed of the drug, maintain constant blood concentration, reduce administration times, avoid uneven drug taking, thereby reducing or eliminating remarkable peak-valley fluctuation of the blood concentration and ensuring that the drug can stably play a therapeutic role for a long time. However, the existing rumen slow release bin may have esophagus blockage or damage in the feeding process, and in addition, the slow release bin may have damage due to insufficient strength of part of the main body and the wings of the slow release bin, and the slow release bin is easy to cause forage winding in the rumen.

Disclosure of Invention

In order to overcome the defects of the prior art, the invention provides a rumen sustained drug delivery system, which comprises a sustained release cabin main body, an end cover and a wing, wherein the sustained release cabin main body is provided with a prismatic outer wall and a cylindrical inner wall, a first end of the sustained release cabin main body is open, a spring and a plunger are arranged in the first end of the sustained release cabin main body, the end cover is combined with the first end of the sustained release cabin main body, the end cover is provided with an opening, the wing is arranged at a second end of the sustained release cabin main body and extends along the radial direction of the sustained release cabin main body, the wing can be bent to be attached to the outer wall of the sustained release cabin main body, a plurality of fish scale grooves are arranged at two sides of the wing, and the fish scale grooves penetrate through the thickness of the wing and are arranged at positions at two sides of the wing in a staggered manner.

Further, the outer wall of the slow release cabin main body is provided with a groove, and the groove is communicated and arranged along the axial direction of the slow release cabin main body.

Further, the outer surface of the slow release cabin main body, which is close to the second end, is formed into an arc shape, a boss is arranged at the end part of the arc surface, and the wing is connected with the boss.

Further, the thickness of the boss along the axial direction of the slow release cabin body is larger than the thickness of the wing, and the width of the boss along the radial direction of the slow release cabin body is larger than the width of the wing.

Further, the slow release cartridge includes a pair of wings extending outwardly in opposite directions of the boss such that the rumen slow release cartridge is formed in a T-shape.

Further, the fish scale groove comprises a first wall surface, a second wall surface and a third wall surface, wherein the first wall surface is parallel to the length direction of the wing, the second wall surface is closer to the boss relative to the third wall surface, the second wall surface is perpendicular to the first wall surface, and an included angle between the third wall surface and the first wall surface is an obtuse angle.

Further, a dimension L1 of the first wall surface along the wing length direction and a dimension L2 of the second wall surface along the wing width direction, wherein L1< L2.

Further, the width of the wing gradually increases from the boss to the tip of the wing.

Further, the upper surface of the wing is provided with a reinforcing rib provided to extend from the boss to approximately the center of the wing along the length direction of the wing.

Further, the tail ends of the wings are bent towards the slow release bin, and a thickened blunt circle is formed.

The invention can at least realize one of the following beneficial effects:

The rumen slow release bin provided by the invention can avoid the phenomenon of esophagus blockage or damage possibly occurring in the feeding process.

The rumen slow release bin provided by the invention reinforces a plurality of parts of the slow release bin main body and the wings, prevents the damage phenomenon caused by insufficient strength of part parts of the slow release bin main body and the wings, and improves the safety and stability;

The rumen slow release bin provided by the invention increases the overall hydrodynamic performance of the slow release bin, and avoids forage winding so as to enhance the effectiveness and practicability of the rumen slow release bin.

Drawings

The invention will be further described with reference to the drawings and examples.

FIG. 1 is a schematic diagram of a rumen sustained drug delivery system of the present invention;

FIG. 2 is a schematic diagram of the piston structure of the rumen sustained drug delivery system of the present invention;

FIG. 3 is a partial cross-sectional view of a rumen sustained drug delivery system of the present invention;

FIG. 4 is an enlarged view of portion B of FIG. 3;

FIG. 5 shows the C-C directional block diagram of FIG. 3, showing bone site structure;

FIG. 6 is a schematic top view of the rumen sustained drug delivery system of the present invention, with broken lines schematically showing the thread-like structure of the fish scale groove;

FIG. 7 is an enlarged view of portion A of FIG. 6;

FIG. 8 is a graph of the results of simulations under forage parameters;

Reference numerals illustrate:

10 rumen sustained drug delivery system, 100 sustained release cabin main body, 101 first end, 102 second end, 110 groove, 120 bone position structure, 130 piston, 131 hole, 140 spring, 200 end cover, 300 wing, 310 fish scale groove, 311 first wall surface, 312 second wall surface, 313 third wall surface, 320 reinforcing rib and 400 boss;

Detailed Description

The conception, specific structure, and technical effects produced by the present invention will be clearly and completely described below with reference to the embodiments and the drawings to fully understand the objects, features, and effects of the present invention. It is apparent that the described embodiments are only some embodiments of the present invention, but not all embodiments, and that other embodiments obtained by those skilled in the art without inventive effort are within the scope of the present invention based on the embodiments of the present invention. In addition, all the connection relationships related in the invention are not direct connection of the single-finger components, but rather can form a better connection structure by adding or reducing connection accessories according to specific implementation conditions. The technical features of the invention can be interactively combined on the premise of no contradiction and conflict.

Referring to fig. 1-7, the rumen sustained drug delivery system 10 provided by the present invention includes a sustained release cartridge body 100, an end cap 200, and wings 300. Wherein, the outer wall of the sustained release cartridge body 100 is prismatic and the inner wall is cylindrical. The sustained release cartridge body 100 includes a first end 101 and a second end 102, wherein the first end 101 is opened and the second end 102 is closed, a spring 140 and a piston 130 are disposed in the sustained release cartridge body 100, and an end cap 200 is combined with the opened first end of the sustained release cartridge body 100, and the end cap 200 is formed with an opening. The wing 300 is disposed at the second end of the sustained-release cartridge body 100 and extends along the radial direction of the sustained-release cartridge body 100, the wing 300 can be bent to be attached to the outer sidewall of the sustained-release cartridge body 100, a plurality of 'fish scale grooves' 310 are disposed at both sides of the wing, and the 'fish scale grooves' 310 are disposed through the thickness of the wing 300 and are staggered at the sites at both sides of the wing 300. Here, the thickness direction of the wings 300 is along the axial direction of the sustained release cartridge body 100. The width direction of the wing 300 is a direction perpendicular to the long side of the wing 300 along the radial direction of the sustained release cartridge body 100. The projection of the fish scale groove, namely the groove in the front view, is in a fish scale shape, as shown in fig. 3 and 4. The staggered arrangement of the fish scale grooves on both sides (widthwise) of the wing 300 forms a thread-like structure as shown in fig. 6 and 7. Wherein, the sustained release cartridge body 100, the end cap 200 and the wings 300 are all made of polypropylene, and the springs are compression springs made of steel.

In one embodiment, in use, compression spring, piston 130, and appropriate amount of tablet are placed in sequence from the bottom of cartridge body 100, and cap 200 is threaded. After rumen continuous drug delivery system 10 enters the rumen, the steel compression spring can continuously push the solid tablets, so that the release surface of the tablets can keep in contact with the inner surface of the end cover and rumen fluid until all the tablets are released. The staggered arrangement of the fish scale grooves 310 on both sides of the wing 300 creates a thread-like structure that, along with rumen rhythmic peristalsis, allows forage wound around the wing to be removed from the device. Thereby preventing forage from winding the rumen slow-release bin and reducing the influence of the rumen slow-release bin on the original physiological function of the rumen.

Specifically, the sustained release cartridge body 100 includes a first end and a second end. The outer surface of the sustained release cartridge body 100 near the second end is formed in an arc shape, and a boss 400 is provided at the end of the arc surface, and the boss 400 and the sustained release cartridge body 100 may be integrally formed or fixedly connected. The wing 300 is preferably fixedly attached to the boss 400. The thickness of the boss 400 along the axial direction of the sustained release cartridge body 100 is greater than the thickness of the wing 300, and the width of the boss 400 along the radial direction of the sustained release cartridge body 100 is greater than the width of the wing 300. The boss 400 is arranged, so that the joint of the sustained-release cabin main body 100 and the wing 300 is reinforced, the circular arc-shaped platform structure of the sustained-release cabin main body 100 is arranged, the stability of a bending area is better protected when the wing 300 is bent, the connection between the wing 300 and the sustained-release cabin main body 100 is enhanced, and the possibility of fracture separation of the wing 300 and the sustained-release cabin main body 100 is reduced. The top of the junction of the cartridge body 100 and the wings 300 is thickened, reinforcing the stability of the connection structure.

The slow release cabin main body 100 is hollow, and the inside of the slow release cabin is a hollow cylinder. Near the connection end, i.e., the second end, with the wing 300, a sheet-like bone site structure 120 corresponding to the external shape is provided, as shown in fig. 5. A platform is formed inside the sustained release cartridge, increasing the stability of the sustained release cartridge body 100 itself and the spring.

In a specific embodiment, the diameter of the inner cylinder of the sustained release cartridge body 100 is 30mm, and six bone-position structures 120 are uniformly distributed inside the sustained release cartridge body 100. The sustained release cartridge body 100 has the appearance of an equilateral hexagonal prism with 20mm sides. The thickness of each edge of the hexagonal prism is equal, the thickness of the wall of the cylinder body is 2.5 mm-5 mm, and the thickness of the wall of the cylinder body is a thickening structure of the wall of the slow release cabin. The design of the wall thickness parameter is further thickened on the basis of the existing product, and is determined according to the size of an administration instrument applied in actual production and the physiology of the dairy cow esophagus. The design has good stability and bearing capacity, provides strength for the bin body, prevents the bin body from being damaged in rumen, causes poisoning caused by excessive medicine, and avoids the conditions of damaging tissues and the like. On the basis of reinforcing the bin body by the hexagonal structure, the volume of the reinforced slow-release bin is minimized. Each edge is designed to be a smooth rounded structure to avoid injuring the esophagus during administration and injuring the rumen wall during rumen retention. The modified sustained release cartridge 10 has a profile that provides enhanced fluid dynamic characteristics that reduces the likelihood of a blocked administration swallow.

In addition, the outer wall of the sustained release cartridge main body 100 is provided with a groove 110, and the groove 110 is provided on the outer surface of the sustained release cartridge main body 100 in a penetrating manner along the axial direction. Providing a recess in the outer wall of the slow release cartridge body 100 can avoid esophageal blockage or damage that may occur during feeding, and slow release cartridges that are ruminated or enter other stomach. Preferably, at least two grooves 110 are provided, and in a specific embodiment, six grooves 110 are uniformly distributed on the outer wall of the sustained release cartridge body 100.

In one particular embodiment, the cartridge body 100 is formed as an equilateral hexagonal cylinder with a semicircular recess formed in each of the ribs extending through the cylinder. Semi-circular r=2.5 mm, a maximum grooving design to ensure a cylinder wall thickness of at least 2.5 mm. The design does not completely fit the esophagus when esophageal blockage occurs. In addition, the wall of the feeder tube, the side surface of the column body and two adjacent edges of the side surface are overhead, a space is reserved, the severity of blocking conditions is reduced, the preparation time for treating emergency is effectively prolonged, and the medication safety is improved. The parameter design of the circular groove is the maximum size designed in the wall thickness range, and the circular groove is prevented from being attached to the esophagus to the maximum extent on the premise of guaranteeing the stability of the rumen continuous administration system 10 body.

Preferably, rumen continuous drug delivery system 10 includes a pair of wings 300, with a pair of wings 300 extending outwardly in opposite directions along boss 400, such that rumen continuous drug delivery system 10 is formed in a T-shape. The pair of wings 300 are each made of an elastic material such that the wings 300 can be folded close to the outer wall of the sustained release cartridge body 100 and can be restored to its original shape after a short time of deformation, i.e., such that the rumen sustained drug delivery system 10 is restored to a T-shape.

The side surface of the outer part of the central area of the two side wings is designed with a 'fish scale-shaped groove', namely a fish scale groove 310, and the groove sites of the two side surfaces of the same side wing are staggered to form a thread-shaped local structure, so that the hydrodynamic characteristics of the wings are enhanced, the forage wound on the wings can be promoted to be further far away from the junction of the wings and the main body along the grooves, the effect of preventing the forage from winding the rumen slow-release bin is achieved, and the influence of the rumen slow-release bin on the original physiological functions of the rumen is greatly reduced. The narrower profile of the wings 300 near the junction is to maintain the flexible characteristics of the wings during feeding, the gradual widening is part of the anti-windup design, which also increases the overall stability of the wings, and the blunt tip is designed to prevent injury to the stomach wall.

Specifically, in fig. 7, the "fish scale groove" 310 includes a first wall 311, a second wall 312, and a third wall 313, wherein the first wall 311 is parallel to the longitudinal direction of the wing 300, the second wall 312 is closer to the boss 400 than the third wall 313, the second wall 312 is perpendicular to the first wall 311, and an included angle between the third wall 313 and the first wall 311 is an obtuse angle. The dimension L1 of the first wall 311 along the wing length direction and the dimension L2 of the second wall 312 along the wing width direction, wherein L1> L2, are more beneficial to the separation of forage. In a particularly preferred embodiment, for example, l1=1.1 mm, l2=0.4 mm, each groove has a uniform parameter and the grooves on the same side are spaced apart a uniform distance. The width of the wing 300 gradually increases from the boss 400 to the tip of the wing 300. The fluid properties of the capsule and wing junction do not cause entanglement. The principle of falling off is that according to the similar screw thread structure formed by staggered arrangement of grooves on two sides of the wing, along with rhythmic peristaltic movement of rumen, forage wound on the wing is separated from the device.

In a particularly preferred embodiment, the design is a partial representation resembling a zigzag thread, with working side β=0°, non-working side β= 63.44 °, p=3 mm, and a root depth of 0.4mm, as shown in fig. 7 (shown in the drawing). The grooves on the two sides are staggered according to the pitch of 3 mm. Zigzag threads are types of threads that provide unidirectional power, and the design is the same as the zigzag thread principle. Under the action of rumen peristaltic force, when the forage is wound on the two side wings and then embedded into the grooves, the working edge prevents the forage from moving to the connecting part, so that the forage moves outwards along the non-working edge. Grooves on two sides of the same flank are staggered, so that the local representation of the thread structure is realized, and the stress of forage in the shedding process is kept consistent. And the wing width gradually increases from the connecting part outwards, the structure of forage becomes loose in the outwards moving process, and finally the forage breaks away from the slow-release capsule, thereby achieving the purpose of winding prevention.

In addition, the center of each wing 300 is provided with a circular prismatic protrusion, which is used as a central skeleton structure of the wing to play a role in strengthening and preventing fracture, so that the initial shape of the wing can be effectively maintained, the elastic weakening of the wing caused by long-term compression is prevented, the T-shaped structure is difficult to maintain, and the rumen retention function is influenced. The whole length of the wings is increased, the safety of the capsule in rumen is increased together with the improved design of the width, and the milk cow milk bag is suitable for the milk cow body growing year by year.

Specifically, the upper surface of the wing 300 (i.e., the surface remote from the body of the sustained release cartridge) is provided with a rib 320, and the rib 320 is provided to extend from the boss 400 to approximately the center of the wing 300 along the length direction of the wing 300. The connection of the sustained-release cabin main body 100 and the wings 300 is reinforced, and the arc-shaped platform structure better protects the stability of the bending area when the wings are bent, so that the connection of the wings 300 and the sustained-release cabin main body 100 is enhanced, and the occurrence frequency of the fracture and separation conditions of the wings and the main body is reduced. The top of the joint of the slow release cabin main body and the wings is thickened, so that the stability of the connecting structure is reinforced.

As shown in fig. 1, the wings 300 form a streamline structure gradually widening from the connection with the boss to the distal end thereof along the length direction, and an arc-shaped rounded structure curving toward the sustained release cartridge body 100 is formed at the distal ends of the wings 300. The gradually widening design makes the rumen sustained drug delivery system 10 easier to insert and the rounded structure prevents injury. The streamlined edge structure of the central region of the two flanks enhances the hydrodynamic performance of the rumen sustained drug delivery system 10 such that the forage cannot be entangled at the junction of the wings and the main body, allowing the forage to be separated from the junction of the wings and the main body along the curved edge during rumen operation. The whole thickness of the wing is reinforced, and the part close to the connecting main body is thickened, so that the stability and the firmness of the wing are maintained. The tail end part of the wing is thickened, so that the safety of the wing in detention in rumen is enhanced, and the design of the tail end rounding can effectively avoid damage to the rumen. The bending area in the middle part keeps the original thickness, maintains the flexibility of the wings, can be well matched with the medicine administration device, and can smoothly enter the rumen through the esophagus.

In addition, the bottom outer wall of the cartridge body 100 may be designed with a screw structure so that it can be combined with the screw structure of the inside of the cap 200. In this design, the bottom cover may maintain a hexagonal structure or may have a circular structure. After the screw thread design is provided, the assembly mode of the medicine is increased, so that the medicine type and dosage can be adjusted according to the body condition and the illness state of the cow, and the possibility is provided for accurate treatment. In addition, the sustained release cartridge body 100 and the end cap 200 may be other connection structures as long as the sustained release cartridge body 100 and the end cap 200 are detachably connected.

The piston 130 and the spring 140 are further disposed inside the sustained release cartridge body 100, the piston 130 is provided with holes 131, in a preferred embodiment, three holes 131 are uniformly disposed on the piston 130, one end of the piston abuts against the spring, and the other end contacts the tablet, so that the tablet can abut against the end cap 200 under the pressure of the spring 140, and release the drug through an opening (not shown) of the end cap 200.

The rumen sustained release system 10 is used by bending the wings down the sustained release cartridge body 100 to fit the outer side wall of the sustained release cartridge body 100, placing the wings into the applicator, feeding the rumen sustained release system 10 into the esophagus through the oral port of the applicator, moving the rumen sustained release system 10 into the rumen through the esophagus, and holding the wings 300 in the stacked position by the esophagus until the rumen sustained release system 10 reaches the rumen. The improved rumen continuous drug delivery system 10 sidewall reduces the likelihood of drug administration swallowing obstruction and reserves space when esophageal obstruction occurs, effectively extending the preparation time for handling the emergency.

The wings 300 will then spring outwardly to the extended position, restoring the T-shape. Rumen continuous administration system 10 is subjected to continuous, intense mechanical stress from undigested food within the rumen and ruminal movements during normal feeding, rumination, and digestion. In this extended position, the wings have a substantially straight outer surface, which ensures that the rumen continuous delivery system 10 does not enter the reticulum and is not carried out of the rumen by the ruminant. The improved rumen sustained drug delivery system 10 of the present invention has a strong hydrodynamic profile and improved wings enhance rigidity, safety, hydrodynamic properties, prevent breakage, folding, and injury of the wings, and increase safety and stability of administration.

The opening in the surface of the end cap 200 is a drug delivery port. Can be retained in rumen for a long time after oral administration, reduce administration times, and reduce stress of milk cow in production link. The rumen slow-release bin of the system can be used for delivering various solid tablet medicines, and can adjust the types and dosages of the medicines before use according to the state of cattle. The rumen continuous administration system has simple production and convenient transportation, and has the effect of improving the economic benefit of pastures. The improved wings strengthen hydrodynamic properties, effectively avoid the entanglement of other foreign matters such as forage, greatly reduce the influence on the original physiological functions of rumen, and increase the effectiveness and practicality of the slow release bin.

Structural simulation verification, see FIG. 8

The model design is that the rumen part is set as a sphere with the diameter of 200mm, and the capsule is positioned at the center of the sphere. The forage is set to be 1mm in diameter and 80mm in length, the texture of the forage is soft (Young modulus is 2e5 pa), and the initial speed is randomly distributed at 0.5-1 m/s.

Through simulation, the length, diameter, moving speed and quantity of the forage are changed, and the phenomenon that the forage fibers are entangled with the capsules in the moving process is not found. This demonstrates that the structure is effective in preventing the problem of being entangled by forage.

While the preferred embodiment of the present application has been described in detail, the present application is not limited to the embodiments, and those skilled in the art can make various equivalent modifications or substitutions without departing from the spirit of the present application, and the equivalent modifications or substitutions are included in the scope of the present application as defined in the appended claims.

Claims (8)

1. A rumen sustained drug delivery system, comprising:

A slow release bin body having a prismatic outer wall and a cylindrical inner wall, a first end of the slow release bin body being open, a spring and a plunger being disposed therein;

An end cover combined with the first end of the slow release bin main body, wherein an opening is formed on the end cover;

The wing is arranged at the second end of the slow release bin main body, the wing extends along the radial direction of the slow release bin main body, the wing can be bent to be attached to the outer wall of the slow release bin main body, a plurality of fish scale grooves are formed in the two sides of the wing, the fish scale grooves penetrate through the thickness of the wing and are staggered at the sites on the two sides of the wing to form a thread-shaped structure, the outer surface of the slow release bin main body, which is close to the second end, is arc-shaped, a boss is arranged at the end part of the arc-shaped surface, the wing is connected with the boss, and the width of the wing gradually increases from the boss to the tail end of the wing.

2. The rumen sustained drug delivery system according to claim 1, wherein the outer wall of the sustained release cartridge body is provided with a groove, and the groove is provided through along the axial direction of the sustained release cartridge body.

3. The rumen sustained drug delivery system of claim 1, wherein the thickness of said boss along the axial direction of the sustained release cartridge body is greater than the thickness of said wings, and the width of said boss along the radial direction of the sustained release cartridge body is greater than the width of said wings.

4. The rumen sustained drug delivery system of claim 1, wherein said sustained release cartridge comprises a pair of wings extending outwardly in opposite directions along a boss such that said rumen sustained release cartridge is formed as a T-shape.

5. The rumen continuous drug delivery system of claim 4, wherein said "fish scale groove" comprises a first wall, a second wall and a third wall, wherein the first wall is parallel to the length of said wing, the second wall is closer to said boss than the third wall, the second wall is perpendicular to the first wall, and the third wall is at an obtuse angle to the first wall.

6. The rumen continuous drug delivery system of claim 5, wherein the first wall has a dimension L1 along the wing length direction and the second wall has a dimension L2 along the wing width direction, wherein L1< L2.

7. The rumen continuous drug delivery system according to claim 1, wherein the upper surface of the wing is provided with a rib arranged to extend from the boss to the center of the wing along the length direction of the wing.

8. The rumen continuous drug delivery system according to claim 7, wherein the distal ends of the wings are curved in the direction of the slow release cartridge and are formed with a blunt rounded shape.