CN118661858A - High-concentration multiple collagen peptide composition and preparation method and application thereof - Google Patents
High-concentration multiple collagen peptide composition and preparation method and application thereof Download PDFInfo
- Publication number
- CN118661858A CN118661858A CN202411149638.1A CN202411149638A CN118661858A CN 118661858 A CN118661858 A CN 118661858A CN 202411149638 A CN202411149638 A CN 202411149638A CN 118661858 A CN118661858 A CN 118661858A
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- collagen peptide
- collagen
- peptide
- pectin
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A—HUMAN NECESSITIES
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- Jellies, Jams, And Syrups (AREA)
Abstract
本发明提供了一种高浓度多重胶原蛋白肽组合物及其制备方法和应用,涉及食品领域,该高浓度胶原蛋白肽组合物包括包括胶原蛋白肽420‑560份,木糖醇20‑40份,透明质酸钠0.5‑2份、果胶0.1‑0.2份和魔芋胶0.1‑0.2份,所述的胶原蛋白肽为胶原蛋白肽A、弹性蛋白肽、胶原蛋白肽B、鳐鱼胶原蛋白肽和鱼低聚肽的混合物。本发明中的胶原蛋白肽组合物具有高含量的多种胶原蛋白肽、口味佳且稳定性良好,能够帮助提升肌肤的保湿、抗糖、抗氧化能力。The present invention provides a high-concentration multiple collagen peptide composition and its preparation method and application, relates to the field of food, the high-concentration collagen peptide composition includes 420-560 parts of collagen peptide, 20-40 parts of xylitol, 0.5-2 parts of sodium hyaluronate, 0.1-0.2 parts of pectin and 0.1-0.2 parts of konjac gum, and the collagen peptide is a mixture of collagen peptide A, elastin peptide, collagen peptide B, skate collagen peptide and fish oligopeptide. The collagen peptide composition in the present invention has a high content of multiple collagen peptides, good taste and good stability, and can help improve the moisturizing, sugar resistance and antioxidant ability of the skin.
Description
技术领域Technical Field
本发明涉及食品领域,具体涉及一种高浓度多重胶原蛋白肽组合物及其制备方法和应用。The present invention relates to the field of food, and in particular to a high-concentration multiple collagen peptide composition and a preparation method and application thereof.
背景技术Background Art
胶原蛋白肽是一类以富含胶原蛋白的新鲜动物组织(包括皮、骨、筋、腱、鳞等)为原料,经过提取、水解、精制生产的,相对分子质量低于10000Da的产品。与其前体原生胶原蛋白相比,胶原蛋白肽的分子量更低,因此易被消化且易为人体吸收。同时,胶原蛋白肽特有的Gly-Pro-Hyp序列也使其具有独特的理化性质和生物活性,不仅可作为保健食品、美容产品、包装材料,还可以作为食品添加剂应用在肉制品改良、冷冻食品、饮料、糕点以及乳制品中。Collagen peptides are a type of product with a relative molecular mass of less than 10,000 Da, which is produced by extraction, hydrolysis and refining of fresh animal tissues rich in collagen (including skin, bones, tendons, tendons, scales, etc.). Compared with its precursor native collagen, collagen peptides have a lower molecular weight, so they are easy to digest and absorb by the human body. At the same time, the unique Gly-Pro-Hyp sequence of collagen peptides also gives them unique physical and chemical properties and biological activity. They can not only be used as health foods, beauty products, and packaging materials, but also as food additives in meat product improvement, frozen foods, beverages, cakes and dairy products.
对于含有胶原蛋白肽的组合物,现有技术如专利CN111938159A公开了一种胶原蛋白肽组合物及其口服液和制备方法,包括以下原料:1-10份蓝莓汁、8-17份鱼胶原蛋白肽、1-7份多元糖醇、0.1-1.5份油脂成分、0.5-5份不饱和脂肪酸、0.01-0.1份维生素。该发明中的口服液长期饮用后,具有良好的抗氧化、抗紫外线伤害、美容养颜、淡斑去皱效果。但该发明中胶原蛋白肽的含量相对较低。For compositions containing collagen peptides, the prior art, such as patent CN111938159A, discloses a collagen peptide composition and its oral liquid and preparation method, which includes the following raw materials: 1-10 parts of blueberry juice, 8-17 parts of fish collagen peptides, 1-7 parts of polysaccharide alcohols, 0.1-1.5 parts of oil components, 0.5-5 parts of unsaturated fatty acids, and 0.01-0.1 parts of vitamins. After long-term drinking, the oral liquid in the invention has good antioxidant, anti-ultraviolet damage, beauty and skin care, and spot lightening and wrinkle removal effects. However, the content of collagen peptides in the invention is relatively low.
再如专利CN115844022A公开了一种包含胶原蛋白肽和维生素C的口服美容组合物及其用途,包含胶原蛋白肽、维生素C、弹性蛋白肽、γ-氨基丁酸(GABA)和血橙粉,能够有效调节皮肤生物节律、促进皮肤中胶原蛋白肽的分泌、改善皱纹、减少皮肤色素沉着。但该发明中组合物针对肌肤的保湿、抗糖、抗氧化能力仍有进一步提升的空间。For example, patent CN115844022A discloses an oral cosmetic composition containing collagen peptide and vitamin C and its use, which contains collagen peptide, vitamin C, elastin peptide, γ-aminobutyric acid (GABA) and blood orange powder, and can effectively regulate skin biorhythm, promote the secretion of collagen peptide in the skin, improve wrinkles, and reduce skin pigmentation. However, the moisturizing, anti-sugar and anti-oxidation capabilities of the composition in this invention are still to be further improved.
再如中国专利CN116268253A中公开了一种透明质酸钠胶原蛋白肽固体饮料及其制备方法,其中固体饮料以重量份计包括如下组份,透明质酸钠0.5-2份、胶原蛋白肽40-80份、维生素C 1-5份、维生素E 0.01-0.02份和功能性辅料10-50份,制备时,首先在洁净区中将透明质酸钠、胶原蛋白肽、维生素C、维生素E和任选的功能性辅料消毒杀菌,然后将消毒杀菌后的各物料过筛,获得均匀一致的各物料,然后称取配方量的透明质酸钠、胶原蛋白肽、维生素C、维生素E和任选的功能性辅料,将各物料加入到清洁的柱式料斗混合机内混合,获得混合均匀的物料,最后将混合均匀的物料装入颗粒包装机,按设定好的内包装净含量继续颗粒包装,制得透明质酸钠胶原蛋白固体饮料,但是该发明中固体饮料胶原蛋白肽种类比较单一,不能更全面的补充多种胶原蛋白。Another example is Chinese patent CN116268253A, which discloses a sodium hyaluronate collagen peptide solid beverage and a preparation method thereof, wherein the solid beverage comprises the following components by weight: 0.5-2 parts of sodium hyaluronate, 40-80 parts of collagen peptide, 1-5 parts of vitamin C, and 1-5 parts of vitamin E. 0.01-0.02 parts and 10-50 parts of functional excipients. During the preparation, sodium hyaluronate, collagen peptide, vitamin C, vitamin E and optional functional excipients are first disinfected and sterilized in a clean area, and then the disinfected and sterilized materials are sieved to obtain uniform materials, and then the formula amount of sodium hyaluronate, collagen peptide, vitamin C, vitamin E and optional functional excipients are weighed, and each material is added to a clean column hopper mixer for mixing to obtain a uniformly mixed material, and finally the uniformly mixed material is loaded into a granule packaging machine, and granule packaging is continued according to the set inner packaging net content to obtain a sodium hyaluronate collagen solid beverage. However, the type of collagen peptides in the solid beverage in this invention is relatively single, and it is not possible to supplement a variety of collagens more comprehensively.
针对现有技术存在的问题,寻找一种高浓度多重胶原蛋白肽组合物及其制备方法和应用十分必要。In view of the problems existing in the prior art, it is necessary to find a high-concentration multiple collagen peptide composition and a preparation method and application thereof.
发明内容Summary of the invention
本发明针对现有技术存在的问题,提供了一种高浓度多重胶原蛋白肽组合物及其制备方法和应用,该胶原蛋白肽组合物具有高含量胶原蛋白肽、口味佳且稳定性良好,能够帮助提升肌肤的保湿、抗糖、抗氧化能力。In view of the problems existing in the prior art, the present invention provides a high-concentration multiple collagen peptide composition and a preparation method and application thereof. The collagen peptide composition has a high content of collagen peptides, good taste and good stability, and can help improve the skin's moisturizing, anti-sugar and anti-oxidation abilities.
为实现上述目的,本发明采用的技术方案如下:To achieve the above purpose, the technical solution adopted by the present invention is as follows:
本发明提供了一种高浓度多重胶原蛋白肽组合物,按重量份数计,包括胶原蛋白肽420-560份、木糖醇20-40份、透明质酸钠0.5-2份、果胶0.1-0.2份和魔芋胶0.1-0.2。The invention provides a high-concentration multiple collagen peptide composition, which comprises, by weight, 420-560 parts of collagen peptide, 20-40 parts of xylitol, 0.5-2 parts of sodium hyaluronate, 0.1-0.2 parts of pectin and 0.1-0.2 parts of konjac gum.
其中,所述的胶原蛋白肽为胶原蛋白肽A、弹性蛋白肽、胶原蛋白肽B、鳐鱼胶原蛋白肽和鱼低聚肽的混合物;Wherein, the collagen peptide is a mixture of collagen peptide A, elastin peptide, collagen peptide B, ray collagen peptide and fish oligopeptide;
所述的胶原蛋白肽A、弹性蛋白肽、胶原蛋白肽B、鳐鱼胶原蛋白肽和鱼低聚肽的质量比为40-48:0.4-2:2-4:0.2-1:0.2-1。The mass ratio of the collagen peptide A, elastin peptide, collagen peptide B, skate collagen peptide and fish oligopeptide is 40-48:0.4-2:2-4:0.2-1:0.2-1.
优选地,所述的胶原蛋白肽A、弹性蛋白肽、胶原蛋白肽B、鳐鱼胶原蛋白肽和鱼低聚肽的质量比为45:1:3:0.5:0.5。Preferably, the mass ratio of the collagen peptide A, elastin peptide, collagen peptide B, skate collagen peptide and fish oligopeptide is 45:1:3:0.5:0.5.
作为一些优选地实施方案,所述的胶原蛋白肽组合物,按重量份数计,包括胶原蛋白肽A 400-480份、弹性蛋白肽4-20份、胶原蛋白肽B 20-40份、鳐鱼胶原蛋白肽2-10份、鱼低聚肽2-10份、木糖醇20-40份、透明质酸钠0.5-2份、果胶0.1-0.2份和魔芋胶0.1-0.2份。As some preferred embodiments, the collagen peptide composition includes, by weight, 400-480 parts of collagen peptide A, 4-20 parts of elastin peptide, 20-40 parts of collagen peptide B, 2-10 parts of ray collagen peptide, 2-10 parts of fish oligopeptide, 20-40 parts of xylitol, 0.5-2 parts of sodium hyaluronate, 0.1-0.2 parts of pectin and 0.1-0.2 parts of konjac gum.
作为另一些优选地实施方案,所述的胶原蛋白肽组合物,按重量份数计,包括胶原蛋白肽A 420-460份、弹性蛋白肽8-15份、胶原蛋白肽B 25-35份、鳐鱼胶原蛋白肽4-8份、鱼低聚肽4-8份、木糖醇25-35份、透明质酸钠1-2份、果胶0.15-0.2份和魔芋胶0.15-0.2份。As other preferred embodiments, the collagen peptide composition includes, by weight, 420-460 parts of collagen peptide A, 8-15 parts of elastin peptide, 25-35 parts of collagen peptide B, 4-8 parts of ray collagen peptide, 4-8 parts of fish oligopeptide, 25-35 parts of xylitol, 1-2 parts of sodium hyaluronate, 0.15-0.2 parts of pectin and 0.15-0.2 parts of konjac gum.
作为一个优选地实施方案,所述的透明质酸钠、果胶和魔芋胶的质量比为5-15:1:1;优选为10:1:1。As a preferred embodiment, the mass ratio of the sodium hyaluronate, pectin and konjac gum is 5-15:1:1; preferably 10:1:1.
作为一个优选地实施方案,所述的胶原蛋白肽组合物,按重量份数计,包括胶原蛋白肽A 450份、弹性蛋白肽10份、胶原蛋白肽B 30份、鳐鱼胶原蛋白肽5份、鱼低聚肽5份、木糖醇30份、透明质酸钠1.5份、果胶0.15份和魔芋胶0.15份。As a preferred embodiment, the collagen peptide composition comprises, by weight, 450 parts of collagen peptide A, 10 parts of elastin peptide, 30 parts of collagen peptide B, 5 parts of skate collagen peptide, 5 parts of fish oligopeptide, 30 parts of xylitol, 1.5 parts of sodium hyaluronate, 0.15 parts of pectin and 0.15 parts of konjac gum.
本发明组合物中以胶原蛋白肽A、弹性蛋白肽、胶原蛋白肽B、鳐鱼胶原蛋白肽和鱼低聚肽的混合物作为基础,多重胶原蛋白肽组合能够更好的提高皮肤保湿效果,增加胶原蛋白含量,使组合物能够更好地提高皮肤弹性,改善皮肤的保水效果。The composition of the present invention is based on a mixture of collagen peptide A, elastin peptide, collagen peptide B, skate collagen peptide and fish oligopeptides. The combination of multiple collagen peptides can better improve the skin moisturizing effect, increase the collagen content, and enable the composition to better improve skin elasticity and improve the skin's water retention effect.
其中,胶原蛋白肽A:平均分子量小于1000Da。其功能是维持皮肤和组织器官的形态和结构,也是修复各损伤组织的重要原料物质。皮肤真皮层中胶原蛋白与成纤维细胞相辅相成,提供皮肤支撑力。胶原蛋白代谢正常,缜密的胶原纤维能起到有效的支撑作用;皮肤老化后胶原蛋白部分流失,会导致支撑皮肤的胶原肽键和弹力网断裂,其结构随即被破坏,皮肤组织被氧化、萎缩、塌陷,肌肤就会出现干燥、皱纹、松弛无弹性等衰老现象。因此,要延缓衰老,必须及时补充胶原蛋白,保证皮肤中胶原蛋白含量足够。Among them, collagen peptide A: the average molecular weight is less than 1000Da. Its function is to maintain the morphology and structure of the skin and tissues and organs, and it is also an important raw material for repairing damaged tissues. Collagen and fibroblasts in the dermis of the skin complement each other and provide support for the skin. When collagen metabolism is normal, the dense collagen fibers can play an effective supporting role; after skin aging, the partial loss of collagen will cause the collagen peptide bonds and elastic network supporting the skin to break, and its structure will be destroyed. The skin tissue will be oxidized, atrophied, and collapsed, and the skin will show aging phenomena such as dryness, wrinkles, sagging and inelasticity. Therefore, to delay aging, collagen must be supplemented in time to ensure that the collagen content in the skin is sufficient.
弹性蛋白肽:是结缔组织中一种重要的蛋白质,因其具有弹性的性质而得名。主要存在于动物的动脉、韧带、软骨、肺和皮肤等富有弹性的组织及器官。弹性蛋白占真皮总蛋白的2%,与胶原蛋白共同存在,比例为1:10,能赋予组织以弹性和抗张能力,在皮肤老化中具有重要作用。它的降解和破坏会造成皮肤弹性减退、皮肤松垂、各种皱纹,甚至出现失去肤色的斑块和结节。Elastin peptide: It is an important protein in connective tissue, named for its elastic properties. It is mainly found in elastic tissues and organs such as animal arteries, ligaments, cartilage, lungs and skin. Elastin accounts for 2% of the total dermal protein and coexists with collagen at a ratio of 1:10. It can give tissues elasticity and tensile strength and plays an important role in skin aging. Its degradation and destruction will cause skin elasticity loss, sagging, various wrinkles, and even patches and nodules that lose skin color.
胶原蛋白肽B:平均分子量小于500Da,CTP含量高于30%,GPH含量高于3.4%。对皮肤保湿,皮肤防皱,骨骼健康及发质均有显著的改善功效。可促进胶原蛋白的合成,增加体内透明质酸含量,达到肌肤保湿、饱满紧致的效果。Collagen peptide B: average molecular weight less than 500Da, CTP content higher than 30%, GPH content higher than 3.4%. It has significant effects on skin moisturizing, skin wrinkle prevention, bone health and hair quality. It can promote the synthesis of collagen, increase the content of hyaluronic acid in the body, and achieve the effect of moisturizing, plumping and firming the skin.
鳐鱼胶原蛋白肽:特有的成分组成及黄金比例,胶原蛋白肽+糖胺聚糖GAGs(硫酸软骨素,氨基葡萄糖,透明质酸等)。优选自海洋软骨鱼,富含胶原和糖胺聚糖GAGs(100%),独特的蛋白多糖成分,能够保持基质水分、锁水保湿,维持皮肤支架结构。Ray Collagen Peptide: Unique composition and golden ratio, collagen peptide + glycosaminoglycan GAGs (chondroitin sulfate, glucosamine, hyaluronic acid, etc.). Selected from marine cartilaginous fish, rich in collagen and glycosaminoglycan GAGs (100%), unique proteoglycan ingredients, can retain matrix moisture, lock in moisture and maintain the skin support structure.
鱼低聚肽:富含四肽(脯氨酸(或羟脯氨酸)-甘氨酸-X-精氨酸),可以竞争性地与体内的葡萄糖或者其他糖衍生物发生反应,从而阻断体内蛋白与其 交联生成 AGEs,从而起到抗糖化的作用。Fish oligopeptides: Rich in tetrapeptides (proline (or hydroxyproline)-glycine-X-arginine), they can competitively react with glucose or other sugar derivatives in the body, thereby blocking the cross-linking of proteins in the body to form AGEs, thereby playing an anti-glycation role.
本发明中还添加了透明质酸钠、果胶和魔芋胶,透明质酸钠具有保湿和修复皮肤的作用,可增加皮肤弹性和柔软度;果胶中含有多种多糖类物质具有较强的抗氧化能力,可以中和自由基,减少氧化损伤,对延缓衰老具有一定的作用;魔芋胶富含胶原蛋白、淀粉等,渗透到体内后,能有效增加饱腹感,此外,可以促进肠道废物的排出,加速肠道蠕动,改善便秘;在实施过程中意外地发现通过控制透明质酸钠、果胶和魔芋胶的质量比,可以明显提高胶原蛋白肽的稳定性,并且能够促使胶原蛋白肽更好的吸收,能够使组合物具有更好的保湿、抗糖和抗氧化效果。The invention further adds sodium hyaluronate, pectin and konjac gum. Sodium hyaluronate has the functions of moisturizing and repairing the skin, and can increase the elasticity and softness of the skin. Pectin contains a variety of polysaccharides with strong antioxidant capacity, can neutralize free radicals, reduce oxidative damage, and has a certain effect on delaying aging. Konjac gum is rich in collagen, starch, etc., and can effectively increase satiety after penetrating into the body. In addition, it can promote the discharge of intestinal waste, accelerate intestinal peristalsis, and improve constipation. In the implementation process, it is unexpectedly found that by controlling the mass ratio of sodium hyaluronate, pectin and konjac gum, the stability of collagen peptide can be significantly improved, and the collagen peptide can be better absorbed, so that the composition can have better moisturizing, anti-sugar and anti-oxidation effects.
作为一些优选地实施方案,所述的胶原蛋白肽组合物,按重量份数计还包括葡萄糖酸锌0.01-0.02份、维生素C 0.05-0.1份、维生素E 0.05-0.1份、甜味剂0.005-0.01份和酸味剂0.01-0.02份。As some preferred embodiments, the collagen peptide composition further comprises, by weight, 0.01-0.02 parts of zinc gluconate, 0.05-0.1 parts of vitamin C, 0.05-0.1 parts of vitamin E, 0.005-0.01 parts of sweeteners and 0.01-0.02 parts of acidulants.
其中,所述的甜味剂包括甜菊糖苷和/或三氯蔗糖,所述酸味剂包括柠檬酸和/或DL-苹果酸。Wherein, the sweetener includes steviol glycoside and/or sucralose, and the acidulant includes citric acid and/or DL-malic acid.
作为一个优选地实施方案,所述的胶原蛋白肽组合物,包括胶原蛋白肽A 450份、弹性蛋白肽10份、胶原蛋白肽B 30份、鳐鱼胶原蛋白肽5份、鱼低聚肽5份、木糖醇30份、透明质酸钠1.5份、果胶0.3份、魔芋胶0.3份、葡萄糖酸锌0.02份、维生素C 0.1份、维生素E 0.1份、甜味剂0.01份、酸味剂0.015份。As a preferred embodiment, the collagen peptide composition includes 450 parts of collagen peptide A, 10 parts of elastin peptide, 30 parts of collagen peptide B, 5 parts of skate collagen peptide, 5 parts of fish oligopeptide, 30 parts of xylitol, 1.5 parts of sodium hyaluronate, 0.3 parts of pectin, 0.3 parts of konjac gum, 0.02 parts of zinc gluconate, 0.1 parts of vitamin C, 0.1 parts of vitamin E, 0.01 parts of sweetener, and 0.015 parts of acidulant.
进一步地,本发明还提供了上述的胶原蛋白肽组合物的制备方法,包括以下步骤:将胶原蛋白肽A、木糖醇、弹性蛋白肽、胶原蛋白肽B、鳐鱼胶原蛋白肽、鱼低聚肽、透明质酸钠、果胶、魔芋胶、葡萄糖酸锌、维生素C、维生素E、甜味剂、酸味剂,混合均匀,即得。Furthermore, the present invention also provides a method for preparing the above-mentioned collagen peptide composition, comprising the following steps: uniformly mixing collagen peptide A, xylitol, elastin peptide, collagen peptide B, skate collagen peptide, fish oligopeptide, sodium hyaluronate, pectin, konjac gum, zinc gluconate, vitamin C, vitamin E, sweetener, and acidulant to obtain the composition.
进一步地,本发明提供的上述的胶原蛋白肽组合物或上述的制备方法制得的胶原蛋白肽组合能够用于制备保湿、抗糖以及抗氧化产品。Furthermore, the collagen peptide composition provided by the present invention or the collagen peptide combination prepared by the above preparation method can be used to prepare moisturizing, anti-sugar and antioxidant products.
进一步地,所述产品还包括可食用的添加剂。Furthermore, the product also includes edible additives.
进一步地,所述产品的剂型包括片剂、粉剂或丸剂。Furthermore, the dosage form of the product includes tablets, powders or pills.
本发明所取得的技术效果是:The technical effects achieved by the present invention are:
(1)本发明组合物中以胶原蛋白肽A、弹性蛋白肽、胶原蛋白肽B、鳐鱼胶原蛋白肽和鱼低聚肽的混合物作为基础,多重胶原蛋白肽组合能够更好的提高皮肤保湿效果,增加胶原蛋白含量,使组合物能够更好地提高皮肤弹性,改善皮肤的保水效果。(1) The composition of the present invention is based on a mixture of collagen peptide A, elastin peptide, collagen peptide B, skate collagen peptide and fish oligopeptide. The combination of multiple collagen peptides can better improve the skin moisturizing effect and increase the collagen content, so that the composition can better improve skin elasticity and improve the skin's water retention effect.
(2)本发明中还添加了透明质酸钠、果胶和魔芋胶,透明质酸钠具有保湿和修复皮肤的作用,可增加皮肤弹性和柔软度;果胶中含有多种多糖类物质具有较强的抗氧化能力,可以中和自由基,减少氧化损伤,对延缓衰老具有一定的作用;魔芋胶富含胶原蛋白、淀粉等,渗透到体内后,能有效增加饱腹感,此外,可以促进肠道废物的排出,加速肠道蠕动,改善便秘;在实施过程中意外地发现通过控制透明质酸钠、果胶和魔芋胶的质量比,可以明显提高胶原蛋白肽的稳定性,并且能够促使胶原蛋白肽更好的吸收,能够使组合物具有更好的保湿、抗糖和抗氧化效果。(2) The present invention also adds sodium hyaluronate, pectin and konjac gum. Sodium hyaluronate has the effect of moisturizing and repairing the skin, and can increase the elasticity and softness of the skin; pectin contains a variety of polysaccharides with strong antioxidant capacity, which can neutralize free radicals, reduce oxidative damage, and have a certain effect on delaying aging; konjac gum is rich in collagen, starch, etc., and after penetrating into the body, it can effectively increase the sense of fullness. In addition, it can promote the discharge of intestinal waste, accelerate intestinal peristalsis, and improve constipation. During the implementation process, it was unexpectedly found that by controlling the mass ratio of sodium hyaluronate, pectin and konjac gum, the stability of collagen peptide can be significantly improved, and the collagen peptide can be better absorbed, so that the composition can have better moisturizing, anti-sugar and antioxidant effects.
(3)本发明还在组合物中添加了葡萄糖酸锌、维生素C、维生素E等辅助营养成分的搭配胶原蛋白的小分子处理,使有效成分能更好地被利用吸收,最终研究开发出一款高含量、口味佳、稳定性良好的胶原蛋白饮品。(3) The present invention also adds auxiliary nutrients such as zinc gluconate, vitamin C, vitamin E, etc. to the composition and processes the collagen with small molecules, so that the effective ingredients can be better utilized and absorbed, and finally develops a collagen drink with high content, good taste and good stability.
具体实施方式DETAILED DESCRIPTION
以下通过特定的具体实例说明本发明的实施方式,本领域技术人员可由本说明书所揭露的内容轻易地了解本发明的其他优点与功效。本发明还可以通过另外不同的具体实施方式加以实施或应用,本说明书中的各项细节也可以基于不同观点与应用,在没有背离本发明的精神下进行各种修饰或改变。The following describes the embodiments of the present invention through specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and the details in this specification can also be modified or changed in various ways based on different viewpoints and applications without departing from the spirit of the present invention.
在进一步描述本发明具体实施方式之前,应理解,本发明的保护范围不局限于下述特定的具体实施方案;还应当理解,本发明实施例中使用的术语是为了描述特定的具体实施方案,而不是为了限制本发明的保护范围。Before further describing the specific embodiments of the present invention, it should be understood that the scope of protection of the present invention is not limited to the specific embodiments described below; it should also be understood that the terms used in the examples of the present invention are for describing specific embodiments rather than for limiting the scope of protection of the present invention.
当实施例给出数值范围时,应理解,除非本发明另有说明,每个数值范围的两个端点以及两个端点之间任何一个数值均可选用。除非另外定义,本文中使用的所有技术和科学术语具有与本发明所属技术领域的普通技术人员通常理解的相同意义。When the embodiment gives a numerical range, it should be understood that, unless otherwise specified in the present invention, the two endpoints of each numerical range and any numerical value between the two endpoints can be selected. Unless otherwise defined, all technical and scientific terms used herein have the same meanings as those of ordinary skill in the art to which the present invention belongs.
以下原料来源,为示例性说明:The following sources of raw materials are provided for illustrative purposes:
胶原蛋白肽A:平均分子量小于1000Da。购自湖北瑞邦生物科技有限公司;胶原蛋白肽B:平均分子量小于500Da,CTP含量高于30%,购自上海昭明实业有限公司;弹性蛋白肽:购自上海瑞欣达健康科技有限公司;鳐鱼胶原蛋白肽:购自上海楷达生物科技有限公司;鱼低聚肽:购自北京盛美诺生物技术有限公司;透明质酸钠:型号8.02-20万,购自山东焦点福瑞达生物股份有限公司;果胶:购自烟台帝斯曼安德利果胶股份有限公司;魔芋胶:购自三原利华生物技术有限公司;葡萄糖酸锌:购自郑州瑞普生物工程有限公司;木糖醇:购自浙江华康药业股份有限公司;其余原料均为普通市售产品,因此对其来源不做具体限定。Collagen peptide A: average molecular weight less than 1000Da. Purchased from Hubei Ruibang Biotechnology Co., Ltd.; collagen peptide B: average molecular weight less than 500Da, CTP content higher than 30%, purchased from Shanghai Zhaoming Industrial Co., Ltd.; elastin peptide: purchased from Shanghai Ruixinda Health Technology Co., Ltd.; skate collagen peptide: purchased from Shanghai Kaida Biotechnology Co., Ltd.; fish oligopeptide: purchased from Beijing Shengminuo Biotechnology Co., Ltd.; sodium hyaluronate: model 80,200-200,000, purchased from Shandong Focus Freda Biological Co., Ltd.; pectin: purchased from Yantai DSM Andre Pectin Co., Ltd.; konjac gum: purchased from Sanyuan Lihua Biotechnology Co., Ltd.; zinc gluconate: purchased from Zhengzhou Ruipu Bioengineering Co., Ltd.; xylitol: purchased from Zhejiang Huakang Pharmaceutical Co., Ltd.; the remaining raw materials are all common commercial products, so their sources are not specifically limited.
实施例1-5一种高浓度胶原蛋白肽组合物及其制备方法Example 1-5 A high concentration collagen peptide composition and its preparation method
实施例1-实施例5的胶原蛋白组合物具体如下表1所示:The specific collagen compositions of Examples 1 to 5 are shown in Table 1 below:
表1Table 1
制备方法具体为以下步骤:将胶原蛋白肽A、木糖醇、弹性蛋白肽、胶原蛋白肽B、鳐鱼胶原蛋白肽、鱼低聚肽、透明质酸钠、果胶、魔芋胶、葡萄糖酸锌、维生素C、维生素E、甜味剂、酸味剂,混合均匀,即得。The preparation method specifically comprises the following steps: uniformly mixing collagen peptide A, xylitol, elastin peptide, collagen peptide B, skate collagen peptide, fish oligopeptide, sodium hyaluronate, pectin, konjac gum, zinc gluconate, vitamin C, vitamin E, sweetener and acidulant to obtain the product.
对比例1Comparative Example 1
与实施例5的区别仅在于,不添加胶原蛋白肽B,胶原蛋白肽A的含量为480份,其他组分的含量不变。The only difference from Example 5 is that collagen peptide B is not added, the content of collagen peptide A is 480 parts, and the contents of other components remain unchanged.
制备方法具体为:将胶原蛋白肽A、木糖醇、弹性蛋白肽、鳐鱼胶原蛋白肽、鱼低聚肽、透明质酸钠、果胶、魔芋胶、葡萄糖酸锌、维生素C、维生素E、甜味剂、酸味剂,混合均匀,即得。The specific preparation method is: evenly mix collagen peptide A, xylitol, elastin peptide, skate collagen peptide, fish oligopeptide, sodium hyaluronate, pectin, konjac gum, zinc gluconate, vitamin C, vitamin E, sweetener and acidulant to obtain the product.
对比例2Comparative Example 2
与实施例5的区别仅在于,不添加鳐鱼胶原蛋白肽和鱼低聚肽,弹性蛋白含量为20份,其他组分的含量不变。The only difference from Example 5 is that the skate collagen peptide and fish oligopeptide are not added, the elastin content is 20 parts, and the contents of other components remain unchanged.
制备方法具体为:将胶原蛋白肽A、木糖醇、弹性蛋白肽、胶原蛋白肽B、透明质酸钠、果胶、魔芋胶、葡萄糖酸锌、维生素C、维生素E、甜味剂、酸味剂,混合均匀,即得。The specific preparation method is: evenly mix collagen peptide A, xylitol, elastin peptide, collagen peptide B, sodium hyaluronate, pectin, konjac gum, zinc gluconate, vitamin C, vitamin E, sweetener and acidulant to obtain the product.
对比例3Comparative Example 3
与实施例5的区别仅在于,将果胶和魔芋胶替换为透明质酸钠,即透明质酸钠1.8份,其他组分的含量不变。The only difference from Example 5 is that pectin and konjac gum are replaced by sodium hyaluronate, namely 1.8 parts of sodium hyaluronate, and the contents of other components remain unchanged.
制备方法具体为:将胶原蛋白肽A、木糖醇、弹性蛋白肽、胶原蛋白肽B、鳐鱼胶原蛋白肽、鱼低聚肽、透明质酸钠、葡萄糖酸锌、维生素C、维生素E、甜味剂、酸味剂,混合均匀,即得。The specific preparation method is: evenly mix collagen peptide A, xylitol, elastin peptide, collagen peptide B, skate collagen peptide, fish oligopeptide, sodium hyaluronate, zinc gluconate, vitamin C, vitamin E, sweetener and acidulant.
对比例4Comparative Example 4
与实施例5的区别仅在于,透明质酸钠、果胶和魔芋胶的质量比为22:1:1,其他组分的含量不变。即:The only difference from Example 5 is that the mass ratio of sodium hyaluronate, pectin and konjac gum is 22:1:1, and the contents of other components remain unchanged. That is:
制备方法具体为:将胶原蛋白肽A、木糖醇、弹性蛋白肽、胶原蛋白肽B、鳐鱼胶原蛋白肽、鱼低聚肽、透明质酸钠、果胶、魔芋胶、葡萄糖酸锌、维生素C、维生素E、甜味剂、酸味剂,混合均匀,即得。The specific preparation method is: evenly mix collagen peptide A, xylitol, elastin peptide, collagen peptide B, skate collagen peptide, fish oligopeptide, sodium hyaluronate, pectin, konjac gum, zinc gluconate, vitamin C, vitamin E, sweetener and acidulant to obtain the product.
对比例5Comparative Example 5
与实施例5的区别仅在于,透明质酸钠、果胶和魔芋胶的质量比为3:1:1,其他组分的含量不变。即:The only difference from Example 5 is that the mass ratio of sodium hyaluronate, pectin and konjac gum is 3:1:1, and the contents of other components remain unchanged. That is:
制备方法具体为:将胶原蛋白肽A、木糖醇、弹性蛋白肽、胶原蛋白肽B、鳐鱼胶原蛋白肽、鱼低聚肽、透明质酸钠、果胶、魔芋胶、葡萄糖酸锌、维生素C、维生素E、甜味剂、酸味剂,混合均匀,即得。The specific preparation method is: evenly mix collagen peptide A, xylitol, elastin peptide, collagen peptide B, skate collagen peptide, fish oligopeptide, sodium hyaluronate, pectin, konjac gum, zinc gluconate, vitamin C, vitamin E, sweetener and acidulant to obtain the product.
一、DPPH自由基清除率测试1. DPPH free radical scavenging rate test
1.1 受试物:实施例1-5以及对比例1-5中的胶原蛋白肽组合物。1.1 Test substances: collagen peptide compositions in Examples 1-5 and Comparative Examples 1-5.
1.2 实验方法:1.2 Experimental methods:
分别取2mL各实施例中胶原蛋白肽组合物加入试管,再向试管中加入2mL浓度为0.1mmol/L的DPPH溶液(使用体积分数为95%的乙醇溶液配制),混合均匀后避光放置30min,测定517nm波长处的吸光度,每组进行三次平行样,取平均值。Take 2 mL of the collagen peptide composition in each example and add it to a test tube, then add 2 mL of 0.1 mmol/L DPPH solution (prepared with 95% ethanol solution by volume) to the test tube, mix well and place in the dark for 30 minutes, measure the absorbance at a wavelength of 517 nm, perform three parallel samples for each group, and take the average value.
其中,DPPH自由基清除率=×100%;Among them, DPPH free radical scavenging rate = ×100%;
上式中,A0为加入受试物后DPPH溶液的吸光度,A为未加受试物时DPPH溶液的吸光度。In the above formula, A0 is the absorbance of DPPH solution after adding the test substance, and A is the absorbance of DPPH solution when no test substance is added.
1.3 实验结果:1.3 Experimental results:
实验结果如下表2所示:The experimental results are shown in Table 2 below:
表2Table 2
根据上表2的检测数据可知,本发明实施例1-5制备的组合物具有较好的清除DPPH自由基的效果,尤其是实施例5制备的组合物清除DPPH自由基的效果最好,达到83%以上;对比例1-2改变胶原蛋白肽的种类会明显影响组合物清除DPPH自由基的效果,对比例3-5中改变透明质酸钠、果胶和魔芋胶的种类或质量比会影响组合物清除DPPH自由基的效果。According to the test data in Table 2 above, the compositions prepared in Examples 1-5 of the present invention have a good effect of scavenging DPPH free radicals, especially the composition prepared in Example 5 has the best effect of scavenging DPPH free radicals, reaching more than 83%; in Comparative Examples 1-2, changing the type of collagen peptide will significantly affect the effect of the composition in scavenging DPPH free radicals, and changing the type or mass ratio of sodium hyaluronate, pectin and konjac gum in Comparative Examples 3-5 will affect the effect of the composition in scavenging DPPH free radicals.
二、弹性蛋白酶活性抑制实验2. Elastase Activity Inhibition Experiment
实验原理:弹性蛋白酶作为具有极高选择性和专一性的蛋白分解酶,对许多氨基酸如甘氨酸、亮氨酸、丙氨酸等含羟基的多肽键具有催化水解的作用,可以缔结组织蛋白质中的弹性蛋白分解。抑制弹性蛋白酶的活性能有效减慢弹性蛋白的降解速度,减少皮肤衰老、皱纹和光老化的产生。Experimental principle: Elastase is a highly selective and specific proteolytic enzyme. It catalyzes the hydrolysis of many amino acids such as glycine, leucine, alanine and other hydroxyl-containing polypeptide bonds, and can decompose elastin in connective tissue protein. Inhibiting the activity of elastase can effectively slow down the degradation of elastin and reduce the occurrence of skin aging, wrinkles and photoaging.
弹性蛋白酶抑制率的测定:在96孔板中加入90 μL缓冲液、30 μL不同浓度的样品稀释液以及10 μL的底物,混匀后置于25 ℃中孵育20 min。随后加入20 μL弹性蛋白酶溶液孵育10 min,检测吸光度,取平均值,检测结果见下表3。Determination of elastase inhibition rate: 90 μL buffer, 30 μL sample diluent of different concentrations and 10 μL substrate were added to a 96-well plate, mixed and incubated at 25 °C for 20 min. Subsequently, 20 μL elastase solution was added and incubated for 10 min, the absorbance was detected, and the average value was taken. The test results are shown in Table 3 below.
按以下公式计算样品的弹性蛋白酶抑制率:The elastase inhibition rate of the sample was calculated according to the following formula:
弹性蛋白酶抑制率(%) = (对照组-实验组)/对照组×100%Elastase inhibition rate (%) = (control group - experimental group) / control group × 100%
表3Table 3
根据上表3的检测数据可以看出,本发明实施例1-5制备的组合物具有更好的抑制弹性蛋白酶的效果,尤其是实施例5制备的组合物抑制弹性蛋白酶的效果最好;对比例1-2改变胶原蛋白肽的种类会明显影响组合物抑制弹性蛋白酶的效果,对比例3-5中改变透明质酸钠、果胶和魔芋胶的种类或质量比会影响组合物抑制弹性蛋白酶的效果。According to the test data in Table 3 above, it can be seen that the compositions prepared in Examples 1-5 of the present invention have better effects on inhibiting elastase, especially the composition prepared in Example 5 has the best effect on inhibiting elastase; in Comparative Examples 1-2, changing the type of collagen peptide will significantly affect the effect of the composition on inhibiting elastase, and changing the type or mass ratio of sodium hyaluronate, pectin and konjac gum in Comparative Examples 3-5 will affect the effect of the composition on inhibiting elastase.
三、人群试食试验3. Human Food Tasting Test
测试样品:实施例1-5和对比例1-5提供的组合物;Test samples: compositions provided in Examples 1-5 and Comparative Examples 1-5;
测试方法:通过发放调查问卷,选择具有皮肤问题的人群。受试者随机分组,每日睡前1h服用1份样品(组合物5g),连续30天。受试者在试验期间不得服用保持皮肤水份、皮肤弹性的物品及影响结果判定的化妆品,试验期间不改变原来的饮食习惯。Test method: A questionnaire was distributed to select people with skin problems. The subjects were randomly divided into groups and took 1 sample (5g of the composition) 1 hour before going to bed every day for 30 consecutive days. During the test, the subjects were not allowed to take items that maintain skin moisture and skin elasticity, or cosmetics that affect the results, and did not change their original eating habits during the test.
在第0天和第30天分别用皮肤含水量测试仪CorneometerCM825检测皮肤含水量,评估饮用前后皮肤的含水量情况,测量时探头在同一受测区域重复测量3次,取平均值。On the 0th day and the 30th day, the skin moisture content was tested with the skin moisture tester Corneometer CM825 to evaluate the skin moisture content before and after drinking. The probe repeated the measurement 3 times in the same tested area and took the average value.
水分含量增长率(%)=[(第30天水分含量-第0天水分含量)/第0天水分含量]×100%。Moisture content growth rate (%) = [(moisture content on the 30th day - moisture content on the 0th day) / moisture content on the 0th day] × 100%.
用皮肤弹性仪CutometerMPA580分别测试第0天和第30天的皮肤状态,测试部位为颧部,测量时探头在同一受测区域重复测量3次,取平均值。The skin elasticity instrument Cutometer MPA580 was used to test the skin condition on the 0th day and the 30th day. The test site was the zygomatic area. The probe was used to repeat the measurement 3 times in the same test area and the average value was taken.
测试参数为R2(无负压时皮肤的回弹量Ua与有负压时的最大拉伸量Uf之比),R2越接近1,皮肤的弹性越好,R2平均变化值=第30天R2值-第0天R2值,R2平均变化率(%)=[R2平均变化值/第0天R2值]×100%。The test parameter is R2 (the ratio of the skin's rebound value Ua when there is no negative pressure to the maximum stretching value Uf when there is negative pressure). The closer R2 is to 1, the better the skin's elasticity. The average change value of R2 = R2 value on the 30th day - R2 value on the 0th day. The average change rate of R2 (%) = [average change value of R2/R2 value on the 0th day] × 100%.
检测结果见下表4。The test results are shown in Table 4 below.
表4Table 4
根据表4的测试数据可知,每日睡前服用本发明实施例1-5制备的组合物30天后,肌肤的水分含量增长率达到10%以上,R2平均变化率达到12%以上。说明本发明制备的组合物可以增加皮肤水分、紧致度和弹性,能够使皮肤细纹减少;对比例1-5制备的组合物服用后效果不如实施例1-5制备的组合物。According to the test data in Table 4, after taking the composition prepared by Examples 1-5 of the present invention before going to bed every day for 30 days, the skin moisture content growth rate reaches more than 10%, and the average R2 change rate reaches more than 12%. This shows that the composition prepared by the present invention can increase skin moisture, firmness and elasticity, and can reduce skin fine lines; the effect of the composition prepared by Comparative Examples 1-5 after taking is not as good as that of the composition prepared by Examples 1-5.
最后应当说明的是,以上内容仅用以说明本发明的技术方案,而非对本发明保护范围的限制,本领域的普通技术人员对本发明的技术方案进行的简单修改或者等同替换,均不脱离本发明技术方案的实质和范围。Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions of the technical solution of the present invention by ordinary technicians in this field do not deviate from the essence and scope of the technical solution of the present invention.
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Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103767034A (en) * | 2014-02-24 | 2014-05-07 | 湖北省农业科学院农产品加工与核农技术研究所 | Nerve-calming beautifying beverage and preparation method thereof |
US20160184218A1 (en) * | 2014-12-29 | 2016-06-30 | Kodimule Prasad | Compositions of amorphophallus konjac and methods for their use in skin care |
CN109549216A (en) * | 2018-12-29 | 2019-04-02 | 上海奥敬生物科技有限公司 | A kind of multiplexed protein anti-aging beauty-care composition, preparation method and application |
US20200222585A1 (en) * | 2019-01-11 | 2020-07-16 | Infinitus (China) Company Ltd. | Composition of collagen peptide and elastin peptide, method of producing the same and use thereof |
CN113875993A (en) * | 2021-12-07 | 2022-01-04 | 北京中科生仪科技有限公司 | Composition for resisting wrinkles, moisturizing and improving skin elasticity and preparation process thereof |
CN114698764A (en) * | 2021-12-22 | 2022-07-05 | 天津泰创生物科技有限公司 | Sodium hyaluronate elastin peptide solid beverage and preparation method thereof |
CN116333186A (en) * | 2023-03-20 | 2023-06-27 | 中华全国供销合作总社南京野生植物综合利用研究所 | Fig pectin, preparation method thereof and application thereof in cosmetics |
CN118415355A (en) * | 2024-07-05 | 2024-08-02 | 浙江衡美健康科技股份有限公司 | Composition for increasing skin elasticity and preparation method and application thereof |
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Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103767034A (en) * | 2014-02-24 | 2014-05-07 | 湖北省农业科学院农产品加工与核农技术研究所 | Nerve-calming beautifying beverage and preparation method thereof |
US20160184218A1 (en) * | 2014-12-29 | 2016-06-30 | Kodimule Prasad | Compositions of amorphophallus konjac and methods for their use in skin care |
CN109549216A (en) * | 2018-12-29 | 2019-04-02 | 上海奥敬生物科技有限公司 | A kind of multiplexed protein anti-aging beauty-care composition, preparation method and application |
US20200222585A1 (en) * | 2019-01-11 | 2020-07-16 | Infinitus (China) Company Ltd. | Composition of collagen peptide and elastin peptide, method of producing the same and use thereof |
CN113875993A (en) * | 2021-12-07 | 2022-01-04 | 北京中科生仪科技有限公司 | Composition for resisting wrinkles, moisturizing and improving skin elasticity and preparation process thereof |
CN114698764A (en) * | 2021-12-22 | 2022-07-05 | 天津泰创生物科技有限公司 | Sodium hyaluronate elastin peptide solid beverage and preparation method thereof |
CN116333186A (en) * | 2023-03-20 | 2023-06-27 | 中华全国供销合作总社南京野生植物综合利用研究所 | Fig pectin, preparation method thereof and application thereof in cosmetics |
CN118415355A (en) * | 2024-07-05 | 2024-08-02 | 浙江衡美健康科技股份有限公司 | Composition for increasing skin elasticity and preparation method and application thereof |
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