CN118594386B - Dry-method granulator - Google Patents

Abstract

The present invention provides a dry granulator, comprising: a housing, a feeding device arranged on one side of the housing, a granulating device arranged on the other side of the housing, and a tabletting device arranged between the feeding device and the granulating device; the tabletting device comprises a symmetrically arranged tabletting assembly and an adjusting assembly, the adjusting assembly is used to adjust the distance and angle between the two tabletting assemblies; the tabletting assembly comprises a plurality of equidistant and continuously distributed tabletting blocks, a transmission component for connecting each tabletting block and a driving component connected to the transmission component, the driving component is used to drive the transmission component so that the plurality of tabletting blocks move along a preset trajectory, thereby forming a pressure channel between the two tabletting assemblies. The present invention solves the problem in the prior art that there is a lack of a dry granulator with high granulation efficiency and high single-tablet drug loading.

Description

A dry granulator

Technical Field

The invention relates to the technical field of traditional Chinese medicine processing equipment, in particular to a dry granulator.

Background Art

In the pharmaceutical industry, most raw materials are in powder form, and they have the characteristics of uneven particle size, poor fluidity, and easy stratification. These raw materials must be processed by granulation before they can be used for tableting, capsule filling or other drug processing procedures. The dry granulator is a granulation process that uses the crystal water in the raw materials to directly compress the raw materials into shape through mechanical extrusion, and then crush and granulate them.

At present, the dry granulator is mainly a roller-type dry granulator, which is mainly composed of a feeding mechanism, a roller mechanism, a crushing mechanism, a granulation mechanism, etc. Its working process is to transport the mixed raw materials through the feeding mechanism, form thin slices with a certain thickness and hardness under the action of the roller, and then break the thin slices into particles through the crushing mechanism, and obtain the desired granular product through the granulation mechanism.

However, the powder may stick to the extrusion wheel during tableting. This is because a large amount of heat and high pressure are generated when the Chinese medicine powder is tableted. Both high temperature and high pressure will make it easy for the Chinese medicine powder to turn from a glassy state to a rubbery state, which will cause the powder to stick to the extrusion wheel.

The existing technology usually reduces the drug loading of the traditional Chinese medicine extract powder by adding auxiliary materials with high glass transition temperature, but this method will reduce the efficacy of the unit product and affect the competitiveness of the product. There is also a way to control the wheel sticking rate by reducing the extrusion pressure, but the current mainstream dry granulators rely on a pair of pressurized wheels to extrude the material into thin sheets. Due to the reduction in pressure, the time for the material to be pressed into a tablet embryo is shorter, and some materials do not have time to be extruded into a tablet embryo and are still in a powder state, so it is necessary to increase the number of granulation times and repeat the extrusion, resulting in a low yield of particles obtained in a single drug, reducing the granulation efficiency and affecting production efficiency and benefits.

Summary of the invention

Based on this, the object of the present invention is to provide a dry granulator, aiming to solve the problem in the prior art of lacking a dry granulator with high granulation efficiency and high single-tablet drug loading.

A dry granulator according to an embodiment of the present invention comprises: a housing, a feeding device arranged on one side of the housing, a granulating device arranged on the other side of the housing, and a tabletting device arranged between the feeding device and the granulating device;

The tablet pressing device comprises a tablet pressing assembly and an adjusting assembly which are symmetrically arranged, and the adjusting assembly is used to adjust the distance and angle between the two tablet pressing assemblies;

The tablet pressing assembly includes a plurality of tablet pressing blocks which are equidistantly and continuously distributed, a transmission component for connecting the various tablet pressing blocks, and a driving component connected to the transmission component, wherein the driving component is used to drive the transmission component so that the plurality of tablet pressing blocks move along a preset trajectory, thereby forming a pressure channel between the two tablet pressing assemblies.

In addition, a dry granulator according to the above embodiment of the present invention may also have the following additional technical features:

Furthermore, the transmission component includes a transmission chain symmetrically arranged on both sides of the tablet pressing block, the driving component includes a driving gear and a driven gear adapted to the transmission chain, and the two ends of the tablet pressing block are respectively connected to the two transmission chains through connecting pieces, and the driving gear and the driven gear drive the multiple tablet pressing blocks to move along an elliptical trajectory through the transmission chain, so that the multiple tablet pressing blocks between the driving gear and the driven gear form a straight and continuous rigid plane.

Furthermore, the tablet pressing block includes a top plate, side plates symmetrically arranged on both sides of the top plate, and a connecting plate for connecting the two side plates. The two sides of one end of the top plate are connected to the transmission chain through the connecting piece, and a circular slider is provided at the bottom of the connecting plate to adapt to the elliptical slide rails arranged on both sides of the tablet pressing block.

Furthermore, the top plate, the side plate and the connecting plate are combined to form the pressing block with a single-sided opening and a fan-shaped cross-section. The top plate is provided with a transition fillet near one end of the connecting piece, and an extension portion extends outward from the other end of the top plate. A avoidance angle is provided at the connection between the extension portion and the connecting plate.

Furthermore, the dry granulator also includes a condensing device, which includes a condensing tube arranged between the driving gear and the driven gear, and the condensing tube is serpentine and evenly distributed in the accommodating space enclosed by the plurality of tablet pressing blocks.

Furthermore, the driving component also includes a driving motor, the condensing device also includes a liquid extraction pump, and a plurality of pulleys are provided on the transmission shaft of the driving gear. The plurality of pulleys are respectively connected to the liquid extraction pump and the driving motor through belts, so that the driving motor drives the liquid extraction pump and the driving gear.

Furthermore, a plurality of heat sinks are equidistantly provided between the two side plates, the heat sinks are respectively connected to the connecting plate and the top plate, a guide plate extends outward from the bottom of the connecting plate, and a preset angle is formed between the guide plate and the top plate.

Furthermore, the tablet pressing device also includes a support frame arranged on the outside of the tablet pressing assembly, and a plurality of support members are provided on the support frame, and the plurality of support members are respectively used to connect the condenser, the slide rail, the driving gear and the driven gear.

Furthermore, the adjustment assembly includes a fixed frame and a plurality of adjustment components arranged on both sides of the fixed frame.

Furthermore, the condensing device also includes hollow annular air rails arranged on both sides of the tablet pressing block. The two annular air rails are provided with air outlet holes on one side close to the tablet pressing block, and the other sides are respectively connected to the external air outlet equipment and air intake equipment through pipes. Heat dissipation holes adapted to the air outlet holes are provided on both sides of the tablet pressing block to connect the annular air rails with the heat dissipation pipelines in the tablet pressing block.

Furthermore, the heat dissipation pipeline includes a plurality of heat dissipation branch pipelines, each of which includes a serpentine spiral condensation section and a straight connecting section. The serpentine spiral condensation sections of the plurality of heat dissipation branch pipelines are respectively and equidistantly distributed in the tablet block to perform zoned condensation on the tablet block, and the straight connecting section is used to connect the serpentine spiral condensation section and the air outlet.

Furthermore, the condensing device also includes a connecting component, which includes a docking plate and a transmission rod connected to the docking plate, one end of the transmission rod is rotatably connected to the docking plate, and the other end is placed in the slide groove of the tablet pressing block so that the docking plate can move up and down relative to the tablet pressing block, the docking plate includes two symmetrically arranged annular segments and a connecting segment connecting the two annular segments, the middle part of the connecting segment is rotatably connected to the transmission rod, the annular segment is used to connect the air outlet and the heat dissipation hole, the annular air rail is recessed inwardly close to the side of the tablet pressing block to form a groove adapted to the docking plate, and the heat dissipation hole is arranged in the groove.

The present invention, by setting a feeding device to stir and mix the feed powder and continuously input it into a tablet pressing device for tablet pressing, and after tablet pressing, the tableting device is used to crush and granulate, so as to complete the process of dry granulation. Among them, through a plurality of equidistant and continuously distributed tablet pressing blocks arranged in the tablet pressing device, a channel with rigid planes on both sides is formed in the tablet pressing device, and the tablet pressing blocks are driven by a driving component to move according to a preset track, so that sufficient shearing force is formed between the upper and lower tablet pressing blocks, and then under the action of sufficient shearing force, the powder in the channel is driven to move and extrude, and then the powder is made into a sheet embryo. Since the powder is continuously extruded by the shearing force of the rigid plane in the channel, the powder can also be pressed into a sheet under the action of low pressure, avoiding the situation that when the roller is used for low-pressure extrusion, the extrusion duration is short, resulting in a situation that part of the material is still in a powder state and needs secondary processing, thereby improving the granulation efficiency. In addition, since the low-pressure tableting method is adopted, and the auxiliary materials with high glass transition temperature are not added to solve the problem of wheel sticking, the efficacy of granulation is guaranteed and the situation of powder wheel sticking is avoided. Furthermore, the present invention solves the problem in the prior art of lacking a dry granulator with high granulation efficiency and high single-tablet drug loading.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG1 is a schematic structural diagram of a dry granulator in a first embodiment of the present invention;

FIG2 is a schematic structural diagram of the dry granulator in the first embodiment of the present invention with the housing partly hidden;

FIG3 is a schematic structural diagram of a tablet pressing assembly in a first embodiment of the present invention;

FIG4 is a schematic diagram of the structure of FIG3 after the film is hidden;

FIG5 is a schematic diagram of the structure of FIG4 after the tablet pressing block is hidden;

FIG6 is a schematic structural diagram of a support frame in a first embodiment of the present invention;

FIG7 is a schematic structural diagram of an adjustment assembly in the first embodiment of the present invention;

FIG8 is a schematic structural diagram of a tablet pressing block in the first embodiment of the present invention;

FIG9 is a schematic structural diagram of FIG8 from another angle;

10 is a schematic structural diagram of a tablet pressing block in a second embodiment of the present invention;

FIG11 is a cross-sectional schematic diagram of a tablet pressing block in a second embodiment of the present invention;

FIG12 is a schematic structural diagram of an annular air track in a second embodiment of the present invention;

The following specific implementation manner will further illustrate the present invention in conjunction with the above-mentioned drawings.

Description of main component symbols:

DETAILED DESCRIPTION

In order to facilitate the understanding of the present invention, the present invention will be described more fully below with reference to the relevant drawings. Several embodiments of the present invention are given in the drawings. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present invention more thorough and comprehensive.

It should be noted that when an element is referred to as being "fixed to" another element, it may be directly on the other element or there may be a central element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are for illustrative purposes only.

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which the present invention belongs. The terms used herein in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and/or" used herein includes any and all combinations of one or more of the related listed items.

Please refer to FIG. 1 to FIG. 9 , which show a dry granulator in a first embodiment of the present invention, comprising: a housing 10, a feeding device 20 disposed on one side of the housing 10, a granulating device 30 disposed on the other side of the housing 10, and a tableting device 40 disposed between the feeding device 20 and the granulating device 30;

The tablet pressing device 40 includes a tablet pressing assembly 41 and an adjusting assembly 42 which are symmetrically arranged, and the adjusting assembly 42 is used to adjust the distance and angle between the two tablet pressing assemblies 41;

The tablet pressing assembly 41 includes a plurality of equidistant and continuously distributed tablet pressing blocks 411, a transmission component 412 for connecting each tablet pressing block 411, and a driving component 413 connected to the transmission component 412. The driving component 413 is used to drive the transmission component 412 to make the plurality of tablet pressing blocks 411 move along a preset trajectory, thereby forming a pressure channel between the two tablet pressing assemblies 41.

It is understandable that the feeding device 20 is provided to stir and mix the feed powder and continuously input it into the tableting device 40 for tableting, and after tableting, the granulation device 30 is used to crush and granulate, so as to complete the process of dry granulation. Among them, a plurality of equidistant and continuously distributed tableting blocks 411 are provided in the tableting device 40, so that a channel with rigid planes on both sides is formed in the tableting device 40, and the tableting blocks 411 are driven by the driving component 413 to move according to a preset trajectory, so that sufficient shear force is formed between the upper and lower tableting blocks 411, and then under the action of sufficient shear force, the powder in the channel is driven to move and squeeze, and then the powder is made into a sheet embryo. Since the powder is continuously squeezed by the shear force of the rigid plane in the channel, the powder can also be pressed into a sheet under the action of low pressure, so as to avoid the situation that when the roller is used for low-pressure extrusion, the extrusion duration is short, resulting in part of the material still being in a powder state and requiring secondary processing, thereby improving the granulation efficiency. In addition, since a low-pressure tableting method is adopted and no auxiliary materials with high glass transition temperature are added to solve the problem of wheel sticking, the drug efficacy of granulation is guaranteed and the phenomenon of powder sticking to the wheel is avoided. Furthermore, the present invention solves the problem of the lack of a dry granulator with high granulation efficiency and high single-tablet drug loading in the prior art.

It should be noted that during dry granulation, the material powder needs to be pressed into a tablet embryo before granulation. Usually, the material powder is poured from top to bottom between two extrusion rollers and pressed into a tablet embryo. Since the volume of a single powder is relatively small compared to the tablet embryo, and the dry process does not allow the powders to adhere to each other through liquid to form a larger volume, and only two static extrusion rollers are set, the material powder will still leave in a powder state after passing through, and the effect of tableting cannot be achieved. Therefore, it is necessary to make the two extrusion rollers rotate relative to each other continuously, and then apply sufficient shear force to the material powder passing through the two extrusion rollers to achieve the function of extrusion tableting. Therefore, if two steel sheets are simply set without applying shear force, the material powder will flow out from between the steel sheets, and the effect of tableting cannot be achieved. If multiple continuously distributed extrusion rollers are set, only intermittent shear extrusion force can be provided, and the material powder cannot be continuously pressed, so that part of the powder is likely to remain in a powder state under low pressure conditions, and powder is likely to accumulate between adjacent extrusion rollers.

By way of example and not limitation, in some optional embodiments, the transmission component 412 includes a transmission chain 4121 symmetrically arranged on both sides of the pressing block 411, the driving component 413 includes a driving gear 4131 and a driven gear 4132 adapted to the transmission chain 4121, and both ends of the pressing block 411 are respectively connected to the two transmission chains 4121 through connecting pieces, and the driving gear 4131 and the driven gear 4132 drive the multiple pressing blocks 411 to move along an elliptical trajectory through the transmission chain 4121, so that the multiple pressing blocks 411 between the driving gear 4131 and the driven gear 4132 form a straight and continuous rigid plane. In specific implementation, a transmission chain 4121 can be used as a transmission component. The transmission chain 4121 is composed of multiple chain links. One end of the chain link is provided with a connecting piece for fixing the chain link to the tableting block. Then, by setting a driving gear 4131 and a driven gear 4132, when the driving gear 4131 drives the driven gear 4132 to rotate through the transmission chain 4121, the tableting block 411 will also rotate. Since the moving trajectory of the tableting block 411 is elliptical, multiple tableting blocks 411 can form a straight rigid plane at the vertical edge of the elliptical trajectory for extruding the powder. Moreover, since a chain transmission method is adopted instead of a conveyor belt friction transmission, the moving speed of the tableting block 411 is only limited by the rotation speed of the driving motor 4133. Therefore, the tableting block 411 can have a sufficient moving speed, and the rigid plane formed by the tableting blocks 411 can provide sufficient shear force for extruding the powder.

Furthermore, the tablet pressing block 411 includes a top plate 4111, side plates 4112 symmetrically arranged on both sides of the top plate 4111, and a connecting plate 4113 for connecting the two side plates 4112. The top plate 4111 is connected to the transmission chain 4121 on both sides through a connecting piece, and a circular slider 4114 is provided at the bottom of the connecting plate 4113 to match the elliptical slide rails 414 arranged on both sides of the tablet pressing block 411. The two sides of the side plates 4112 are respectively connected to the connecting piece, and the circular sliders 4114 are provided at both sides of the bottom of the connecting plate 4113 to match the outer slide rails 414, so that the tablet pressing block 411 moves under the action of the circular sliders 4114 and the connecting piece, and the slide rails 414 are provided so that when the tablet pressing block 411 moves along the elliptical track, the top plate 4111 of the tablet pressing block 411 always faces the outside, thereby ensuring the stable formation of a rigid plane. In addition, the connecting piece and the circular slider 4114 provide support force for the tablet pressing block 411, thereby ensuring that the tablet pressing block 411 can stably extrude the material powder, ensuring the spacing between the upper and lower tablet pressing blocks 411, and thus ensuring the extrusion force on the material powder, so that the tablet pressing block 411 will not be deflected or move up and down due to the force, affecting the pressure size.

Furthermore, the top plate 4111, the side plate 4112 and the connecting plate 4113 are combined to form a tablet block 411 with a single-sided opening and a fan-shaped cross-section. The top plate 4111 is provided with a transition fillet 4115 near one end of the connecting piece, and an extension portion 4116 is extended outward from the other end of the top plate 4111. An avoidance angle is provided at the connection between the extension portion 4116 and the connecting plate 4113. Specifically, by making the transition fillet 4115 and the avoidance angle cooperate with each other, the tablet block 411 moves along an elliptical trajectory, and when it moves to the arc, there is no interference between adjacent tablet blocks 411, thereby ensuring the stable movement of the tablet block 411. In addition, by the extension portion 4116 extending outward, the extension portion 4116 abuts against and covers the transition fillet 4115 of the adjacent tablet block 411, thereby ensuring that there is no gap between adjacent tablet blocks 411, so that multiple tablet blocks 411 can form a continuous rigid plane. In addition, By abutting against the extension portion 4116 and the adjacent tableting blocks 411, when the tableting blocks 411 and the material powder interact with each other, the reaction force of the material powder will be applied to all the tableting blocks 411 abutting against each other, that is, applied to all the tableting blocks 411 on the elliptical straight line, and then the reaction force of the material powder is shared by multiple tableting blocks 411, thereby further ensuring that the tableting blocks 411 will not move under the reaction force of the material powder, ensuring the distance between the upper and lower tableting blocks 411, and then applying a stable low pressure to the material powder to ensure the tableting effect.

In addition, the dry granulator also includes a condensing device 50, which includes a condensing tube 51 arranged between the driving gear 4131 and the driven gear 4132, and the condensing tube 51 is evenly distributed in the accommodation space enclosed by a plurality of tableting blocks 411 in a serpentine spiral. Since a large amount of heat will be generated when the material powder is extruded, and the high temperature will make the material powder easily adhere to the tableting block 411, the condensing tube 51 is provided so that the condensing tube 51 and the air in the accommodation space can achieve heat exchange, thereby ensuring the temperature near the tableting block 411. In addition, the condensing tube 51 evenly arranged in a serpentine spiral can increase the contact area between the condensing tube 51 and the outside world, thereby improving the condensation effect. In addition, in the specific implementation, a coolant or condensed water can be used in the condensing tube 51 to achieve the cooling effect of the condensing tube.

Specifically, the driving component 413 further includes a driving motor 4133, the condensing device 50 further includes a liquid extraction pump 52, and a plurality of pulleys 4134 are further provided on the transmission shaft of the driving gear 4131, and the plurality of pulleys 4134 are respectively connected to the liquid extraction pump 52 and the driving motor 4133 through belts, so that the driving motor 4133 drives the liquid extraction pump 52 and the driving gear 4131. The pulleys 4134 are respectively connected to the driving motor 4133 and the liquid extraction pump 52 through belts, so that when the driving motor 4133 drives the driving gear 4131 to rotate, the liquid extraction pump 52 is synchronously driven to extract liquid, thereby realizing that the driving motor 4133 drives the tablet pressing assembly 41 and the condensing device 50 to operate simultaneously. In addition, when the granulation efficiency needs to be improved, the speed of the driving motor 4133 needs to be increased so that the tableting block 411 can move quickly, thereby enabling the powder to be extruded and transported quickly, and the heat generated by extruding the powder will be greater than the normal efficiency. As the speed of the driving motor 4133 increases, the pumping efficiency of the liquid pump 52 will be improved simultaneously, thereby increasing the flow rate of the condensed liquid in the condenser 51, further improving the condensation effect of the condensation device 50, so that the heat generated by the extrusion of the tableting block 411 will be quickly dissipated, thereby avoiding the situation where the powder sticks due to high temperature.

In addition, a plurality of heat sinks 4117 are equidistantly arranged between the two side plates 4112, and the heat sinks 4117 are respectively connected to the connecting plate 4113 and the top plate 4111, and a guide plate 4118 extends outward from the bottom of the connecting plate 4113, and a preset angle is formed between the guide plate 4118 and the top plate 4111. Specifically, by providing a plurality of heat sinks 4117 and adjusting the material of the heat sink 4117, the heat dissipation effect at the top plate 4111 is increased in disguised form, and the powder is prevented from easily sticking to the top plate 4111 due to high temperature, and the overall structural strength of the tablet pressing block 411 is enhanced, and the tablet pressing block 411 is ensured not to be deformed by external force, thereby ensuring the spacing between the upper and lower tablet pressing blocks 411. By setting guide vanes 4118 at the bottom of the connecting plate 4113, when the pressing block 411 moves along an elliptical trajectory, the multiple guide vanes 4118 form a state similar to the blade distribution and moving trajectory of a centrifugal fan, thereby achieving the effect of a centrifugal fan, that is, the gas in the accommodating space enclosed by the pressing block 411 will move radially of the guide vanes 4118, and then the gas near the condenser tube 51 will move toward the top plate 4111 and the heat sink 4117, thereby increasing the condensation efficiency in disguised form. In addition, when the granulation efficiency is improved by increasing the rotation speed of the driving motor 4133, even if the heat generated at the tablet block 411 is greater than that during normal granulation, the movement speed of the tablet block 411 increases, and the movement speed of the guide plate 4118 also increases accordingly, and the movement speed of the gas at the condenser 51 to the top plate 4111 and the heat sink 4117 also increases, thereby increasing the condensation efficiency. Thus, through the above-mentioned increase in the flow rate of the condensed liquid and the increase in the movement speed of the gas near the condenser 51, the two act simultaneously, so that even if the production efficiency is improved, it can be ensured that the powder will not stick, without the need to adjust the pressure or temperature additionally to increase the production cost. In addition, the angle between the guide plate 4118 and the top plate 4111 can be adjusted according to the size and position of the elliptical motion trajectory, and then the disturbance effect generated when the guide plate 4118 moves can be adjusted to ensure the speed at which the gas moves to the top plate 4111 and the heat sink 4117.

By way of example and not limitation, in some optional embodiments, a film 415 is sleeved on the outside of the tabletting block 411, and a fastener is provided on the connecting member so that the film 415 is fixed on the outside of the tabletting block 411 and moves with the tabletting block 411. In a specific implementation, even if an extension 4116 is provided to ensure that there is no gap between adjacent tabletting blocks 411, in order to ensure that there is no gap between the tabletting blocks 411, multiple tabletting blocks 411 can move quickly and form a straight rigid plane, which requires a high precision requirement for the size and shape of the tabletting block 411, thereby increasing the difficulty and cost of processing. In addition, the assembly requirements for the entire device are also very high, which will increase the overall manufacturing cost of the dry granulator in disguise. Therefore, in a specific implementation, a film 415 can also be provided on the outside of the tabletting block 411, and the film 415 is fixed on the outside of the tabletting block 411 by a fastener, so that the film 415 moves with the tabletting block 411. Therefore, since the film 415 is provided, there is no gap between the tableting blocks 411, which prevents the material powder from entering the tableting assembly 41. In addition, since the tableting block 411 supports the film 415 and rigidly squeezes the material powder, it is prevented that when the film 415 squeezes the powder, the powder applies a reverse force to the film 415. Due to the elastic material of the film 415 itself, it is deformed, resulting in changes in the size of the pressure channels, affecting the pressure stability. In addition, through the rigid connection between the film 415 and the tableting block 411, the movement of the film 415 moves with the tableting block 411, rather than being driven by friction, so that sufficient shear force can be provided for squeezing the material powder. The effect of powder tableting is guaranteed.

In addition, the tablet pressing device 40 also includes a support frame 43 arranged outside the tablet pressing assembly 41, and a plurality of support members 431 are provided on the support frame 43, and the plurality of support members 431 are respectively used to connect the condenser 51, the slide rail 414, the driving gear 4131 and the driven gear 4132. Specifically, by providing the support frame 43 and the support member 431, the tablet pressing device 40 can be fixed in the housing 10 and operate stably. In addition, in the specific implementation, the support frame 43 is in a semi-closed state, so that the tablet pressing device 40, except for the plurality of tablet pressing blocks 411 constituting the rigid plane, is mostly hidden inside the support frame 43, which not only protects the internal parts of the tablet pressing device 40, but also prevents the airflow generated by the movement of the guide plate 4118 from affecting the powder. In addition, on the side away from the feeding device 20, the vertical partition of the support frame 43 and the film 415 are against each other, and the contact surface is inclined, which is used to scrape off the sticking powder that may exist on the film 415.

Specifically, the adjustment assembly 42 includes a fixed frame 421 and a plurality of adjustment components 422 arranged on both sides of the fixed frame 421. The fixed frame 421 is provided to accommodate and protect the adjustment components 422. In addition, by providing a plurality of adjustment components 422 on both sides, when it is necessary to adjust the distance between the upper and lower tablet pressing assemblies 41 to adjust the powder extrusion force, it is necessary to drive a plurality of adjustment components 422 at the same time. When it is necessary to adjust the relative distance between the upper and lower tablet pressing assemblies 41 so that a pressure channel with a gradual pressure change is formed between the tablet pressing assemblies 41, it is necessary to control the adjustment components 422 on both sides respectively to control the displacement of the two sides of the tablet pressing assembly 41 to different degrees.

In addition, in the specific implementation, the tablet pressing device 40 can be tilted as a whole, that is, the two tablet pressing components 41 are tilted relative to the feeding device 20 and the granulating device 30, so that the material powder can be pressed into tablets and can be more easily dropped into the granulating device 30 relative to the horizontal setting. In addition, a stirring rod is provided in the feeding device 20 for stirring the feeding powder to make the material mixing more uniform. In addition, the feeding device 20 includes a feeding pipe, and a spiral auger is provided in the feeding pipe for feeding the stirred powder into the tablet pressing device 40. The granulating device 30 includes a crusher and a screen, and the pressed tablet embryos are crushed and granulated by the crusher, and the crushed material is fed into the outlet. The screen is located between the crusher and the outlet, and the screen is used to screen the material particles with the particle size meeting the standard. When the crusher feeds the crushed material into the outlet, the crushed material falls on the screen, and the material particles with the particle size meeting the standard pass through the screen, enter the outlet, and are collected. The material particles that do not meet the standard are screened on the screen, which is convenient for secondary processing.

Please refer to Figures 10 to 12, which show a dry granulator in the second embodiment of the present invention. The first embodiment and the second embodiment have basically the same structure, except that the condensing device 50 further includes hollow annular air rails 53 arranged on both sides of the tableting block 411. The two annular air rails 53 are provided with air outlets 531 on one side close to the tableting block, and the other side is connected to the external air outlet device and air intake device through pipelines. The tableting block 411 is provided with heat dissipation holes 418 adapted to the air outlets 531 on both sides, so that the annular air rails 53 are connected to the heat dissipation pipeline in the tableting block 411. It should be noted that since the present device continuously extrudes the powder at low pressure to make tablets, although the pressure applied is smaller and the instantaneous heat generated is lower than that of the high pressure of the extrusion roller in the prior art, the surface of the single tableting block 411 is extruded for a longer time due to the longer duration, so the total heat generated is not low. Although the temperature required for the powder to be converted from the glass state to the rubber state under the low pressure state is higher, it is also necessary to dissipate the heat in time to prevent the occurrence of the wheel sticking condition. Therefore, in addition to providing a condenser 51 to cool the environment inside the device and indirectly cool the tablet pressing block 411, an annular wind track 53 is also provided, and a heat dissipation pipeline is provided in the tablet pressing block 411. Through the air supply equipment and the air intake equipment, the low-temperature gas is passed through the annular wind track 53 and into the heat dissipation pipeline of the tablet pressing block 411, so as to directly dissipate the heat of the tablet pressing block 411, thereby ensuring that the temperature of the tablet pressing block 411 is maintained within a preset range, and preventing the occurrence of the situation where the powder is converted from the glass state to the rubber state.

Furthermore, the heat dissipation pipeline includes a plurality of heat dissipation branch pipelines 416, and the heat dissipation branch pipelines 416 include a serpentine spiral condensation section 4161 and a straight connecting section 4162. The serpentine spiral condensation sections 4161 of the plurality of heat dissipation branch pipelines 416 are respectively and equidistantly distributed in the tablet block 411 to perform zone condensation on the tablet block 411, and the straight connecting section 4162 is used to connect the serpentine spiral condensation section 4161 and the air outlet 531. In specific implementation, in order to achieve a good condensation effect in each area of the surface of the tablet block 411 and perform direct condensation, the heat dissipation pipeline is usually arranged in a serpentine spiral in the tablet block 411, so that the condensed gas stays in the tablet block 411 for as long as possible, and the contact area is as large as possible, thereby achieving a better condensation effect. However, if only one heat dissipation pipeline is set, the condensed gas has a good heat dissipation effect when it first enters the heat dissipation pipeline, but as time goes by, the condensation effect will become worse and worse, resulting in a good condensation effect on one side of the pressing block 411 and a poor condensation effect on the other side. Therefore, by setting up multiple independent heat dissipation branch pipelines 416, the pressing block 411 is partitioned and condensed through the serpentine condensation sections 4161 of the multiple heat dissipation branch pipelines 416, thereby ensuring that each part of the pressing block 411 has a good condensation effect, and then through the straight connecting section 4162, the condensed airflow quickly enters the serpentine condensation section 4161, thereby increasing the air intake rate.

Furthermore, the condensing device 50 also includes a connecting component 54, which includes a docking plate 541 and a transmission rod 542 connected to the docking plate 541. One end of the transmission rod 542 is rotatably connected to the docking plate 541, and the other end is placed in the slide groove 417 of the pressing block 411 so that the docking plate 541 can move up and down relative to the pressing block 411. The docking plate 541 includes two symmetrically arranged annular segments 5411 and a connecting segment 5412 connecting the two annular segments 5411. The middle part of the connecting segment 5412 is rotatably connected to the transmission rod 542. The annular segment 5411 is used to connect the air outlet 531 and the heat dissipation hole 418. The annular air rail 53 is recessed inwardly on the side close to the pressing block 411 to form a groove 532 adapted to the docking plate 541, and the heat dissipation hole 418 is arranged in the groove 532. In the specific implementation, in order to ensure the air intake effect, the pressing block 411 and the annular wind rail 53 need to be close enough without hindering the movement of the pressing block 411. However, due to processing accuracy, assembly errors, production efficiency and other reasons, collision or friction between the pressing block 411 and the annular wind rail 53 is inevitable. Therefore, it is necessary to connect the annular wind rail 53 and the pressing block 411 by setting a connecting component 54, and the stiffness and hardness of the connecting component 54 are lower than those of the pressing block 411 and the annular wind rail 53. Therefore, when there is a collision or friction, due to the buffering effect and material reasons of the connecting component 54, only the connecting component 54 will be rubbed or damaged, rather than the annular wind rail 53 and the pressing block 411 being worn or damaged. Therefore, the connecting component 54 can be directly replaced, and the connecting component 54 has lower cost and is more convenient to replace. By way of example and not limitation, in some optional embodiments, since a plurality of heat dissipation holes 418 are provided, for example two, the docking plate 541 of the connecting component 54 includes two symmetrically arranged annular segments 5411 adapted to the heat dissipation holes 418 so that the heat dissipation holes 418 and the air outlet holes 531 are connected. However, since the pressing block 411 is performing an annular motion with an elliptical trajectory, when the pressing block 411 moves to the arc section of the elliptical trajectory, the docking plate 541 will interfere with the annular wind track 53. Therefore, a transmission rod 542 is provided to be rotatably connected to the docking plate 541, and the transmission rod 542 can move up and down relative to the pressing block 411 through the slide groove 417, so that the docking plate 541 can move up and down and rotate relative to the pressing block 411, and then the docking plate 541 will move along the annular wind track 53 without interference. When the pressing block 411 moves to the straight section of the elliptical trajectory, the annular wind track 53 limits the freedom of the docking plate 541 in the height direction, and the slide groove 417 limits the freedom of the docking plate 541 in the left and right directions, so that the docking plate 541 will automatically reset, thereby connecting the heat dissipation hole 418 with the air outlet hole 531.

In summary, the present invention stirs and mixes the feed powder by setting a feeding device 20 and continuously inputs it into a tableting device 40 for tableting, and crushes and granulates it through a granulation device 30 after tableting, thereby completing the process of dry granulation. Among them, a plurality of equidistant and continuously distributed tableting blocks 411 are set in the tableting device 40, so that a channel with rigid planes on both sides is formed in the tableting device 40, and the tableting blocks 411 are driven by a driving component 413 to move according to a preset trajectory, so that sufficient shear force is formed between the upper and lower tableting blocks 411, and then under the action of sufficient shear force, the powder in the channel is driven to move and squeeze, and then the powder is made into a sheet embryo. Since the powder is continuously squeezed by the shear force of the rigid plane in the channel, the powder can also be pressed into a sheet under the action of low pressure, avoiding the situation that when the roller is used for low-pressure extrusion, the extrusion duration is short, resulting in part of the material still being in a powder state and requiring secondary processing, thereby improving the granulation efficiency. In addition, since a low-pressure tableting method is adopted and no auxiliary materials with high glass transition temperature are added to solve the problem of wheel sticking, the drug efficacy of granulation is guaranteed and the phenomenon of powder sticking to the wheel is avoided. Furthermore, the present invention solves the problem of the lack of a dry granulator with high granulation efficiency and high single-tablet drug loading in the prior art.

In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "examples", "specific examples", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner.

The above-mentioned embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the patent of the present invention. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims (5)

1. A dry granulator, comprising: the device comprises a shell, a feeding device arranged on one side in the shell, a grain sizing device arranged on the other side in the shell, and a tabletting device arranged between the feeding device and the grain sizing device;

The tabletting device comprises symmetrically arranged tabletting assemblies and adjusting assemblies, and the adjusting assemblies are used for adjusting the distance and the angle between the two tabletting assemblies;

The pressing assembly comprises a plurality of pressing blocks which are distributed at equal intervals and are continuously arranged, a transmission part used for connecting each pressing block and a driving part connected with the transmission part, wherein the driving part is used for driving the transmission part to enable the pressing blocks to move along a preset track, so that a pressure channel is formed between the two pressing assemblies;

The driving part comprises driving gears and driven gears which are symmetrically arranged on two sides of the pressing blocks, the driving part comprises driving gears and driven gears which are matched with the driving chains, two ends of the pressing blocks are respectively connected with the two driving chains through connecting pieces, and the driving gears and the driven gears drive the pressing blocks to move along an elliptical track through the driving chains so that a plurality of pressing blocks between the driving gears and the driven gears form a straight continuous rigid plane;

The pressing piece comprises a top plate, side plates symmetrically arranged on two sides of the top plate and a connecting plate used for connecting the two side plates, wherein two sides of one end of the top plate are connected with the transmission chain through the connecting piece, and a circular sliding block is arranged at the bottom of the connecting plate and is matched with oval sliding rails arranged on two sides of the pressing piece;

the top plate, the side plates and the connecting plate are enclosed to form the tabletting block with a single-sided opening and a fan-shaped section, a transition round angle is arranged at one end of the top plate, which is close to the connecting piece, an extending part is outwards extended at the other end of the top plate, and an avoidance angle is arranged at the joint of the extending part and the connecting plate;

The dry granulating machine further comprises a condensing device, wherein the condensing device comprises a condensing pipe arranged between the driving gear and the driven gear, and the condensing pipe is coiled and uniformly distributed in a containing space formed by encircling a plurality of tabletting blocks;

the condensing device further comprises hollow annular air rails arranged on two sides of the tabletting block, the two annular air rails are close to one side of the tabletting block and are provided with air outlets, the other side of the annular air rails is connected with external air outlet equipment and air suction equipment through pipelines, and the two sides of the tabletting block are provided with heat dissipation holes matched with the air outlets so that the annular air rails are communicated with heat dissipation pipelines in the tabletting block.

2. The dry granulator according to claim 1, wherein the driving unit further comprises a driving motor, the condensing unit further comprises a liquid pump, a plurality of pulleys are further arranged on a transmission shaft of the driving gear, and the pulleys are respectively connected with the liquid pump and the driving motor through belts, so that the driving motor drives the liquid pump and the driving gear.

3. The dry granulator according to claim 1, wherein a plurality of cooling fins are equidistantly arranged between the two side plates, the cooling fins are respectively connected with the connecting plate and the top plate, the bottom of the connecting plate extends outwards to form a guide vane, and a preset angle is formed between the guide vane and the top plate.

4. The dry granulator of claim 1 wherein the heat dissipation circuitry comprises a plurality of heat dissipation branch circuitry comprising serpentine coiled condensing segments each equidistantly disposed within the tablet block for zone condensation of the tablet block and straight line communication segments for communicating the serpentine coiled condensing segments with the air outlet.

5. The dry granulator according to claim 4, wherein the condensing unit further comprises a connecting member, the connecting member comprises a transmission rod connected with the butt plate, one end of the transmission rod is rotatably connected with the butt plate, the other end of the transmission rod is arranged in a chute of the tablet block so as to enable the butt plate to move up and down relative to the tablet block, the butt plate comprises two symmetrically arranged annular sections and a connecting section connected with the two annular sections, the middle part of the connecting section is rotatably connected with the transmission rod, the annular sections are used for communicating the air outlet holes and the heat dissipation holes, a groove matched with the butt plate is formed by inwards recessing one side of the annular air rail close to the tablet block, and the heat dissipation holes are formed in the groove.