CN118534143A - Full-automatic high-speed biochemical analyzer - Google Patents

Abstract

The present invention discloses a fully automatic high-speed biochemical analyzer, comprising: a reaction disk unit, an automatic reaction cup cleaning unit, a mixing unit, an optical detection unit, a reagent disk unit, a reagent needle unit, an automatic reagent loading and unloading unit, a sample disk unit, a sample track unit and a sample needle unit; the sample disk unit is used to load and transfer samples, and cooperates with the sample needle unit to absorb samples, the sample disk unit is suitable for single-machine sampling, and the sample track unit is suitable for online sampling; the sample needle unit is located in a triangular area formed by the reaction disk unit, the sample disk unit and the sample track unit, and includes two sample needles with different arm lengths, and the two sample needles are sampled at the same point of the sample track unit; the sample needle with a longer arm length is used to sample on the sample disk unit and/or the sample track unit. The fully automatic and efficient biochemical analyzer provided by the present invention has a more reasonable structural design, more complete functions, and higher detection efficiency and accuracy.

Description

A fully automatic high-speed biochemical analyzer

Technical Field

The present invention relates to the technical field of medical testing equipment, and in particular to a fully automatic high-speed biochemical analyzer.

Background Art

The fully automatic biochemical analyzer is a routine clinical analytical instrument in hospitals, mainly used to measure various biochemical indicators in human body fluids, including routine blood tests, myocardial enzyme spectrum, blood sugar and blood lipids, liver function, immunoglobulins and other routine biochemical indicators. The current biochemical analyzers are usually equipped with several reagent trays for placing reagent containers, and reagents are drawn by reagent needles and injected into reaction cups placed on the reaction trays, so that several reagents are mixed with samples in the reaction trays, and the absorbance of the solution is automatically measured. In order to increase the test throughput, the reagent volume in a single reagent tray is usually arranged as two inner and outer circles, and two reagent needles are used to draw the reagent containers in the inner and outer circles and fill them into the reaction containers.

Therefore, based on the structure and use of the above-mentioned biochemical analyzer, it is found that the existing biochemical analyzers on the market have the following problems:

First, in the existing biochemical analyzer, when two sample needles take samples from the conventional sampling track, the sampling efficiency is low. When sampling, the track needs to be switched back and forth to the respective sampling points of the sample needles, which leads to increased software interaction and reduced reliability.

Second, in existing biochemical analyzers, the residue on the inner and outer walls of the sample needle will gradually increase after repeated use. Conventional water flushing cannot completely clean it and cannot eliminate the cross contamination caused by the sample needle during the sampling process, resulting in low accuracy of the test results.

Third, the existing biochemical analyzers generally only use a single transmission absorbance method for analysis during optical detection and analysis. The test method is single, the signal change is not sensitive in the low concentration area, and the accuracy of the results is not high;

Fourth, the existing biochemical analyzers cannot meet the test requirements of saccharification projects, and the test functions are not comprehensive enough;

Fifth, the existing biochemical analyzer cannot realize automatic human-computer interaction on-line reagents. When changing reagents, it is necessary to stop or pause the sample addition, which makes it inconvenient to change reagents and affects the detection efficiency of the biochemical analyzer.

Sixth, in the existing biochemical analyzers, the sample needle cannot take samples from both the track and the sample tray. The way the sample needle takes samples from the sample tray is generally a stand-alone method of use, and the way the sample needle takes samples from the sample track is generally an online method of use, that is, it cannot be used both stand-alone and online. The sampling method is rigid, not flexible enough, and the design is not reasonable enough.

Summary of the invention

In view of the deficiencies of the prior art, the object of the present invention is to provide a fully automatic high-speed biochemical analyzer with a more reasonable structural design, more complete functions, and higher detection efficiency and accuracy.

The technical solution adopted by the present invention to solve the technical problem is: a fully automatic high-speed biochemical analyzer, comprising:

The reaction tray unit is used to load the reaction cups and transport the reaction cups to the corresponding working positions for performing corresponding analysis operations;

The reaction cup automatic cleaning unit is used to automatically clean the reaction cup that has reached the cleaning position;

A mixing unit, located next to the stirring position, is used to stir the mixed solution in the reaction cup located on the stirring position after adding the sample and/or reagent;

An optical detection unit, including a transmission module and a scattering module, is used to perform optical detection on the reactants in the reaction cup;

The reagent disk unit is located on the left side of the reaction disk unit and is used to load reagent bottles of different specifications and transport the reagent bottles to the reagent suction position to cooperate with the reagent needle unit to suck the reagent;

The reagent needle unit is located between the reagent disk unit and the reaction disk unit, and is mainly used to draw a specified amount of reagent from the reagent bottle and inject the reagent into the reaction cup located at the reagent adding position;

An automatic reagent loading and unloading unit is arranged above the reagent tray unit, and automatically grabs reagent bottles from the track and places them in the reagent tray unit, or grabs reagent bottles in the reagent tray unit that are not to be tested by the instrument and places them on the track;

The sample tray unit is located on the right side of the reaction tray unit and is used to load and transport samples or quality control products, transport the sample tube to the sample suction position, and cooperate with the sample needle unit to suck the sample; the sample tray unit is mainly used for single-machine sampling;

The sample track unit includes at least one sample tube transport track, which is used to transport sample tubes from the sample centralized management area to the sampling position, and cooperates with the sample needle unit to absorb samples. The sample track unit is mainly used for online sampling, including being connected to the sample centralized management area or other automated testing instruments;

The sample needle unit is located in a triangular area formed by the reaction disk unit, the sample disk unit and the sample track unit; the sample needle unit includes two sample needles with different arm lengths, and the two sample needles take samples at the same point of the sample track unit; the sample needle with a longer arm length is used to take samples on the sample disk unit or the sample track unit.

Furthermore, the biochemical analyzer also includes an ultrasonic cleaning module, a saccharification cleaning tank and an ISE unit; the ultrasonic cleaning module is located between the sample disk unit and the sample track unit, and is on the running route of the sample needle, and is used to deeply clean the sample needle; the saccharification cleaning tank is located between the reaction disk unit and the sample track unit, and is on the running route of the sample needle, and is used to clean the sample needle after the saccharification item test; the ISE unit is composed of Na ⁺ , K ⁺ , Cl ^- selective electrodes, a reference electrode, an injection and measurement channel, a syringe, a thermal stabilization unit, a degassing unit and a waste liquid discharge component.

Furthermore, the reaction disk unit includes a reaction disk assembly, a reaction cup, and a constant temperature assembly; the reaction cup is placed in the reaction disk assembly, the reaction disk assembly is driven by a two-stage transmission method, and the constant temperature assembly provides a constant temperature environment for the reaction in the reaction cup by water bath heating.

Furthermore, the automatic reaction cup cleaning unit includes a cleaning needle, a lifting motor and related fluid circuits; the lifting motor controls the cleaning needle to ascend and descend, and automatically completes the cleaning of the reaction cup.

Furthermore, the mixing units are distributed around the reaction disk unit, and the mixing units are designed with three mixing stirring heads, so as to stir the mixed liquid in the reaction cup by combining the mechanical reciprocating motion of the stirring heads with the rotary stirring.

Furthermore, in the optical detection unit, the transmission module is located on one side of the reaction disk unit, and the detection optical axis of the transmission module is perpendicular to the reaction cup to be detected, and is used to test most biochemical items; the scattering module is located on the other side of the reaction disk unit, and the detection optical axis of the scattering module is perpendicular to the reaction cup to be detected, and forms a certain pitch angle with the reactants in the reaction cup in the horizontal direction, and is specifically located in the triangular area formed by the reaction disk unit, the sample needle unit and the mixing unit, and is used to test low-concentration biochemical items.

Furthermore, the reagent disc unit includes a reagent disc assembly with a disc-type structure design, the reagent disc assembly includes an inner ring and an outer ring with independent rotation control, and the inner ring and the outer ring are respectively equipped with different reagent needle units for interactive liquid extraction; the reagent disc assembly has a 24-hour uninterrupted refrigeration function; the reagent barcode scanning assembly is used to automatically obtain reagent information; the reagent disc assembly adopts a tensioning adjustable mechanism, two sets of synchronous belts and a stepper motor drive structure, has the freedom of rotation in one direction along the vertical direction, and can realize forward and reverse rotation through motor control.

Furthermore, the reagent needle unit is mainly composed of a reagent needle, a reagent needle rocker arm, a reagent needle drive shaft, a reagent syringe, a reagent needle cleaning tank and related liquid circuits; each reagent disk unit is equipped with two sets of reagent needle units with opposite movement directions; the reagent needle unit has anti-collision protection functions in both horizontal and vertical directions; the reagent needle unit has liquid level detection, volume tracking and empty suction alarm functions.

Furthermore, the automatic reagent loading and unloading unit includes a horizontal rail, a vertical rail and a human-machine reagent exchange platform; the horizontal rail is responsible for horizontal movement, and the vertical rail is responsible for vertical movement, so as to realize taking out empty reagent bottles from the designated position of the reagent tray unit to the human-machine reagent exchange platform, and taking reagent bottles from the human-machine reagent exchange platform and placing them into the designated position of the reagent tray unit.

Furthermore, the sample tray unit includes a sample tray assembly with a disc-type structure design; the sample tray assembly has a refrigeration function, which is used to perform low-temperature temperature control on samples or quality control products in the central area; the sample barcode scanning assembly is used to automatically obtain sample information; the sample tray assembly adopts a tensioning adjustable mechanism, two sets of synchronous belts and a stepper motor drive structure, and has the freedom to rotate in one direction along the vertical direction, and can achieve forward and reverse rotation through motor control.

Furthermore, when the sample track unit is in an online state, the sample tube moves from left to right or from right to left driven by the sample tube transport track; when the sample tube reaches the sampling point along the sample tube transport track, both sample needles can move to the same sampling point for sampling.

Furthermore, the sample needle unit is mainly composed of a sample needle, a sample needle rocker arm, a sample needle drive shaft, a sample syringe, a sample needle cleaning tank and related liquid circuits; the sample needle unit has anti-collision protection functions in both horizontal and vertical directions; the sample needle unit has liquid level detection and volume tracking functions.

Furthermore, the sample needle includes a first sample needle and a second sample needle, the arm length of the first sample needle is greater than the arm length of the second sample needle; the first sample needle is located at the right part of the sample needle unit, close to the sample disk unit, and the second sample needle is located at the left part of the sample needle unit, close to the reaction disk unit; the first sample needle meets the requirements of sampling in the sample disk unit when in a stand-alone state and in the sample track unit when in an online state.

The beneficial effects of the present invention are: compared with the prior art, the biochemical analyzer provided by the present invention has the following advantages:

1) The present invention designs the arm lengths and position layouts of the two sample needles so that the sample track does not need to switch sampling points back and forth when the two sample needles take samples from the sample injection track. The two sample needles can take samples at the same point on the sample injection track. The design is more reasonable, the sample needle sampling efficiency is higher, the sample track does not need to switch back and forth, and the software interaction is less;

2) The present invention adds an ultrasonic cleaning module, which uses a combination of ultrasonic cleaning and conventional water washing. Less residue is left on the inner and outer wall surfaces of the sample needle, which can more thoroughly eliminate cross contamination and provide a more accurate test result.

3) In the present invention, the newly added nephelometry scattering module is more sensitive to signal changes in the low concentration area, has higher accuracy when testing in the low concentration area, and has more accurate detection results;

4) The present invention can meet the function of glycation testing. Since the glycation project is to test the glycated hemoglobin in red blood cells, after the sample is centrifuged, the red blood cells are in the lower layer, and the sample needs to be sucked from the bottom to suck the red blood cells. Therefore, the depth of the sample needle being contaminated is very deep. The present invention designs a glycation cleaning pool to ensure the cleaning of the sample needle after glycation; in addition, the sample needle supporting glycation is designed to be thinner; the process of hemolysis and release of glycated proteins in red blood cells needs to be optimized in terms of timing; the overall testing function of the present invention is more comprehensive, and the instrument has a higher cost performance;

5) The present invention has the function of automatically replacing reagent bottles. After placing the reagent at the designated position of the human-machine interaction, the automatic reagent loading and unloading unit can automatically grab the reagent from the specific position of the human-machine interaction and place it in the corresponding position of the reagent tray without stopping the instrument, and then take out the empty reagent bottle and place it in the human-machine interaction reagent placement area; this greatly reduces the time for human intervention in replacing reagents and greatly expands the number of reagents available for the instrument itself;

6) The sample needle of the present invention can satisfy the needs of sampling on the sample plate when in a stand-alone mode, and can also satisfy the needs of sampling on the sample track when in an online mode, and the structural design and layout design are more reasonable.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG1 is a schematic diagram of the structure of a biochemical analyzer provided by the present invention.

FIG. 2 is a schematic diagram of two sample needles taking samples from a sampling track unit in a biochemical analyzer provided by the present invention.

FIG. 3 is a schematic diagram of sampling of the first sample from the track and the sample disk in the biochemical analyzer provided by the present invention.

FIG. 4 is a schematic diagram of the structure of the automatic reagent loading and unloading unit in the biochemical analyzer provided by the present invention.

FIG. 5 is a schematic diagram of the structure of a sample needle in a biochemical analyzer provided by the present invention.

FIG6 is a schematic diagram of the structure of a scattering module in a biochemical analyzer provided by the present invention.

FIG. 7 is a schematic diagram of the structure of an ultrasonic cleaning unit in a biochemical analyzer provided by the present invention.

Among them, 110-first reagent needle unit; 120-second reagent needle unit; 130-transmission module; 140-reaction cup automatic cleaning unit; 150-reaction disk unit; 160-first mixing unit; 170-sample disk unit; 180-sample tube; 190-ISE unit; 200-sample track unit; 210-ultrasonic cleaning module; 211-ultrasonic cleaning tank; 212-ultrasonic cleaning tank body; 213-ultrasonic transducer; 214-ultrasonic cleaning column; 220-first sample needle unit; 230-second sample needle unit; 231-sample needle; 232-sample needle rocker arm; 233-spline bearing; 234-sample needle seat; 235- Slide rail; 236-pipeline; 240-saccharification cleaning tank; 250-scattering module; 251-first photoelectric detection board; 252-first main body; 253-second main body; 254-second photoelectric detection board; 255-mounting plate; 256-support column; 260-second mixing unit; 270-third reagent needle unit; 280-fourth reagent needle unit; 290-first reagent disk unit; 300-human-machine reagent exchange platform; 310-reagent bottle; 320-automatic reagent loading and unloading unit; 321-cross rail; 322-lateral motion component; 323-reagent grabber for replacement; 324-reagent platform placement plate; 330-second reagent disk unit; 340-reaction cup.

DETAILED DESCRIPTION

The present invention is further described below by specific examples, but these examples are only used to illustrate the present invention and are not used to limit the scope of the present invention.

Example

As shown in Figures 1 to 7, a fully automatic high-speed biochemical analyzer comprises:

The reaction tray unit 150 is used to load the reaction cup 340 and transport the reaction cup 340 to corresponding working positions, including a reagent adding position, a sample adding position, a stirring position, and a cleaning position, to perform corresponding analysis operations;

The reaction cup automatic cleaning unit 140 is used to automatically clean the reaction cup 340 that has arrived at the cleaning position;

A mixing unit, located next to the stirring position, is used to stir the mixed liquid in the reaction cup 340 located on the stirring position after adding the sample and/or reagent;

An optical detection unit, including a transmission module 130 and a scattering module 250, for optically detecting the reactants in the reaction cup 340;

The reagent disk unit is located on the left side of the reaction disk unit 150 and is used to load reagent bottles 310 of different specifications and transport the reagent bottles 310 to the reagent suction position to cooperate with the reagent needle unit to suck the reagent;

The reagent needle unit is located between the reagent disk unit and the reaction disk unit 150, and is mainly used to draw a specified amount of reagent from the reagent bottle 310 and inject the reagent into the reaction cup 340 located at the reagent adding position;

The automatic reagent loading and unloading unit 320 is arranged above the reagent tray unit, and automatically grabs the reagent bottle 310 from the track and places it in the reagent tray unit, or grabs the reagent bottle 310 in the reagent tray unit that is not to be tested by the instrument and puts it on the track;

The sample tray unit 170 is located on the right side of the reaction tray unit 150 and is used to load and transport samples or quality control products, transport the sample tube 180 to the sample suction position, and cooperate with the sample needle unit to suck the sample; the sample tray unit 170 is mainly used for single-machine sampling;

The sample track unit 200 includes at least one sample tube transport track, which is used to transport the sample tube 180 from the sample centralized management area to the sampling position, and cooperates with the sample needle unit to absorb the sample. The sample track unit 200 is mainly used for online sampling, including being connected to the sample centralized management area or other automated testing instruments;

The sample needle unit is located in a triangular area formed by the reaction disk unit 150, the sample disk unit 170 and the sample track unit 200; the sample needle unit includes two sample needle units with two sample needles 231 of different arm lengths, namely a first sample needle unit 220 and a second sample needle unit 230, and the two sample needles 231 take samples at the same point of the sample track unit 200; the sample needle with a longer arm length is used to take samples on the sample disk unit 170 or the sample track unit 200.

The biochemical analyzer also includes an ultrasonic cleaning module 210, a saccharification cleaning pool 240 and an ISE unit 190; the ultrasonic cleaning module 210 is located between the sample disk unit 170 and the sample track unit 200, and is located on the running route of the sample needle, and is used to perform deep cleaning on the sample needle; in the normal sampling process, ultrasonic cleaning is not required every time the sample needle sucks the sample to the reaction disk, but ultrasonic cleaning is performed only after the sample needle unit has been sampled for a certain time or frequency or each time it is turned on, so as to achieve the purpose of thoroughly cleaning the surface of the sample needle. The ultrasonic cleaning module 210 includes an ultrasonic cleaning tank 211, an ultrasonic cleaning pool body 212, an ultrasonic transducer 213 and an ultrasonic cleaning column 214.

The saccharification cleaning pool 240 is located between the reaction disk unit 150 and the sample track unit 200 and on the running route of the sample needle, and is used to clean the sample needle after the saccharification project test; when doing the saccharification project, the sample needle is inserted into the bottom of the sample tube 180, and the sample is sucked into the reaction cup 340 at the specified position of the reaction disk, and then the sample is spit out and sent to the special saccharification cleaning pool 240 for a clean and thorough cleaning.

The ISE unit 190 is composed of Na ⁺ , K ⁺ , Cl ^-selective electrodes, reference electrodes, injection and measurement channels, syringes, thermal stabilization units, degassing units and waste liquid discharge components. The ISE unit 190 is located on the right side of the sample needle unit and is mainly used to measure the concentration of sodium, potassium and chloride ions in serum, plasma and diluted urine. The measurement principle is the indirect ion electrode selection method.

The reaction disk unit 150 includes a reaction disk assembly, a reaction cup 340, and a constant temperature assembly; the reaction cup 340 is placed in the reaction disk assembly, and during the analysis process, the designated reaction cup 340 is transported to the corresponding reagent adding position, sample adding position, stirring position, and cleaning position. The reaction disk assembly is driven by a two-stage transmission method, which can greatly reduce noise and cost while ensuring accuracy. The reaction cup 340 uses a permanent reaction cup, which is used as a reaction container for colorimetric measurement. The constant temperature assembly provides a constant temperature environment for the reaction in the reaction cup 340 by heating in a water bath. The design of the reaction disk unit 150 has great advantages in terms of cost, accuracy, performance, etc.

The automatic cleaning unit 140 of the reaction cup includes a cleaning needle, a lifting motor and related liquid circuits; the lifting motor controls the cleaning needle to rise and fall, and automatically completes the cleaning of the reaction cup 340. After the test, the reaction cup 340 is automatically cleaned by eight groups of cleaning needles. Vertical range of motion: After the bottom of the cleaning needle touches the bottom, the steel needle can be lifted about 2mm, and there is no interference in the movement above the operating table; anti-collision protection: The cleaning needle with a scriber is pressed against the mounting surface by a spring. After the steel needle is hit and stressed, the scriber compresses the spring, passes through the sensor, and triggers the protection mechanism.

The mixing unit is distributed around the reaction disk unit 150. The mixing unit adopts a three-head mixing and stirring head design. The mixed liquid in the reaction cup 340 is stirred by combining the mechanical reciprocating motion of the stirring head with the rotary stirring, and the speed is adjustable in closed-loop control. The driving mechanism and the swing arm of the mixing unit are driven by a stepper motor synchronous belt and a linear guide rail to drive the lifting; the stepper motor and the synchronous belt drive the swing arm to rotate. This design can save space and cost to the greatest extent while meeting the needs. Preferably, the mixing unit includes a first mixing unit 160 and a second mixing unit 260, the first mixing unit 160 is located at the upper right of the reaction disk, and the second mixing unit 260 is located below the reaction disk. Each mixing unit has three stirring rods, and the three stirring rods are evenly distributed around the circumference. When one stirring rod is stirring, the other two stirring rods are rinsing at the same time.

In the optical detection unit, the transmission module 130 is located on one side of the reaction disk unit 150, and the detection optical axis of the transmission module 130 is perpendicular to the reaction cup 340 to be detected, and is used to test most biochemical items; the scattering module 250 is located on the other side of the reaction disk unit 150, and the detection optical axis of the scattering module 250 is perpendicular to the reaction cup 340 to be detected, and forms a certain pitch angle with the reactants in the reaction cup 340 in the horizontal direction, and is specifically located in the triangular area formed by the reaction disk unit 150, the sample needle unit and the mixing unit, and is used to test low-concentration biochemical items. The scattering module 250 includes a first scattering module, a second scattering module, a mounting plate 255 and a support column 256, the first scattering module includes a first photoelectric detection plate 251 and a first main body 252, and the second scattering module includes a second photoelectric detection plate 254 and a second main body 253; during detection, the reaction cup 340 is placed in the groove of the first main body 252 or the second main body 253.

The optical detection unit uses a photoelectric conversion method to convert the optical change signal caused by the chemical reaction into an electrical signal, and reflects the change in light intensity by detecting the change in the electrical signal. Compared with the traditional optical detection unit with only a transmission module 130, the combination of transmission and scattering can detect more test items.

The reagent disc unit includes a reagent disc assembly with a disc-type structure design, and the reagent disc assembly includes an inner ring and an outer ring that are individually controlled, and the inner ring and the outer ring are respectively equipped with different reagent needle units; the reagent disc assembly has a 24-hour uninterrupted refrigeration function; it is used to ensure that the reagents in the reagent bottle 310 are always stored in a low-temperature environment to keep the reagents stable and reduce volatility. The reagent barcode scanning component is used to automatically obtain reagent information; the reagent disc assembly adopts a tension adjustable mechanism, two sets of synchronous belts and a stepper motor drive structure, and has the freedom of rotation in one direction along the vertical direction, and can realize forward and reverse rotation through motor control.

There are two sets of reagent disk units, including a first reagent disk unit 290 and a second reagent disk unit 330. The first reagent disk unit 290 and the second reagent disk unit 330 are arranged side by side between the reaction disk unit 150 and the automatic reagent loading and unloading unit 320. Each set of reagent disk units is equipped with two sets of reagent needle units. Four sets of reagent needle units are distributed between the reagent disk unit and the reaction disk unit 150. The two sets of reagent needles that take reagents from the same reagent disk unit move in opposite directions during sampling to prevent collision during the sampling process.

The reagent needle unit is mainly composed of a reagent needle, a reagent needle rocker arm, a reagent needle drive shaft, a reagent syringe, a reagent needle cleaning pool and related liquid circuits; each reagent disk unit is equipped with two sets of reagent needle units with opposite movement directions. There are four sets of reagent needle units, including a first reagent needle unit 110, a second reagent needle unit 120, a third reagent needle unit 270 and a fourth reagent needle unit 280; wherein the first reagent needle unit 110 and the second reagent needle unit 120 are matched with the first reagent disk unit 290, and are respectively used to complete the absorption of reagents from the inner circle and the outer circle of the first reagent disk unit 290 to the reaction disk unit 150; the first reagent needle unit 110 and the second reagent needle unit 120 have opposite movement directions during sampling; in addition, the third reagent needle unit 270 and the fourth reagent needle unit 280 are matched with the second reagent disk unit 330, and are respectively used to complete the absorption of reagents from the inner circle and the outer circle of the second reagent disk unit 330 to the reaction disk unit 150; the third reagent needle unit 270 and the fourth reagent needle unit 280 have opposite movement directions during sampling.

The reagent needle unit has anti-collision protection function in both horizontal and vertical directions; the reagent disk is sampled in the horizontal direction, and the reaction disk is added, and the horizontal direction has anti-collision protection function. Through the code disk counting, the sensor alarm is triggered after receiving the obstruction, and the automatic protection system will be enabled to prevent the reagent needle from being damaged; the vertical lifting stroke, the high position meets the rotation of the reaction disk, and the low position meets the bottom of the reagent bottle 310 to absorb the sample, and the vertical direction has anti-collision protection function. After the reagent needle is lifted a certain distance, the anti-collision sensor alarm is triggered. If a collision occurs, the automatic protection system will be enabled to prevent the reagent needle from being damaged.

The reagent needle unit has the functions of liquid level detection, volume tracking and empty suction alarm. The liquid level in the reagent bottle 310 can be automatically detected, and the depth below the liquid level can be determined according to the amount of liquid sucked. When the reagent is insufficient or there are bubbles that cause the reagent needle to suck insufficient liquid or cannot suck liquid, the system will generate an alarm.

The automatic reagent loading and unloading unit 320 includes a horizontal rail 321, a vertical rail and a human-machine reagent exchange platform 300; the human-machine reagent exchange platform 300 includes a reagent replacement gripper 323 and a reagent platform placement plate 324. The horizontal rail 321 is responsible for horizontal movement, and the vertical rail is responsible for vertical movement, so as to realize taking out an empty reagent bottle 310 from a designated position of the reagent tray unit to the human-machine reagent exchange platform 300, and taking out a reagent bottle 310 from the human-machine reagent exchange platform 300 and putting it into a designated position of the reagent tray unit. This greatly reduces the time for human intervention in replacing reagents and greatly expands the number of reagents available for the instrument itself.

The sample tray unit 170 includes a sample tray assembly designed with a disc-type structure, which is used to load sample tubes 180, turn each sample tube 180 to the sample suction position, and wait for the sample needle to suck the sample. The sample tray assembly has a refrigeration function; the upper part of the sample tray assembly is used to load sample tubes 180, and the lower part is a refrigeration chamber, and the inside, outside and bottom are all provided with a heat preservation cotton structure to keep the sample at a low temperature; in addition to loading samples, the sample tray assembly can also be used to store quality control products. The sample barcode scanning assembly is used to automatically obtain sample information; the sample tray assembly adopts a tensioning adjustable mechanism, two sets of synchronous belts and a stepper motor drive structure, and has the freedom to rotate in one direction along the vertical direction, and can realize forward and reverse rotation through motor control.

When the sample track unit 200 is online, the sample tube 180 moves from left to right or from right to left driven by the sample tube transport track; when the sample tube 180 reaches the sampling point along the sample tube transport track, both sample needles can move to the same sampling point for sampling; the sample needle sampling efficiency is higher and the software interaction is less.

The sample needle unit is mainly composed of a sample needle 231, a sample needle rocker arm 232, a sample needle drive shaft, a sample syringe, a sample needle seat 234, a slide rail 235, a pipeline 236, a sample needle cleaning pool and related liquid circuits; the sample needle drive shaft adopts a spline bearing 233. The sample needle unit has a liquid aspiration detection function, and a liquid level detection plate is installed on the sample needle swing arm. When the liquid level detection fails, the needle is blocked, the suction is empty, or the clot occurs, the sample needle stops adding samples, and the system issues a warning. The sample needle unit has anti-collision protection functions in both horizontal and vertical directions; the horizontal direction stroke meets the sampling of the track sampling position and the sample disk sampling position; the horizontal direction has an anti-collision protection function, through the code disk counting, the sensor alarm is triggered after receiving the obstruction, and the automatic protection system will be enabled to prevent the sample needle from being damaged. The vertical lifting stroke meets the high position without affecting the rotation of the colorimetric disk; the low position meets the bottom of the test tube for aspiration; the vertical direction has an anti-collision protection function, after the sample needle is lifted a certain distance, the anti-collision sensor alarm is triggered, and the automatic protection system will be enabled to prevent the sample needle from being damaged. The sample needle unit has the functions of liquid level detection and volume tracking; it can automatically detect the liquid level in the sample tube 180 and determine the depth below the liquid level according to the amount of liquid aspirated. The combination of ultrasonic cleaning and conventional water flushing can achieve lower needle surface residues and significantly reduce the result errors caused by residue influence factors; the sample needle as a whole adopts a lightweight design and cost-reducing design.

The sample needle includes a first sample needle and a second sample needle, the arm length of the first sample needle is greater than the arm length of the second sample needle; the first sample needle is located at the right part of the sample needle unit, close to the sample disk unit 170, and the second sample needle is located at the left part of the sample needle unit, close to the reaction disk unit 150; the first sample needle meets the requirements of sampling in the sample disk unit 170 when in a stand-alone state and in the sample track unit 200 when in an online state.

The two sample needle units can be used to perform sampling at the same sampling point of the sample track unit 200. This effect is achieved mainly due to the following three reasons: first, the arm lengths of the two sample needle units are determined based on a comprehensive consideration of the sampling point, the sample addition point, and the sample needle installation position; second, in the structure of the sample needle, the lifting and lowering of the sample needle is guided by a combination of a guide rail and a spline bearing 233, and a mechanical directional limit is also performed in the rotation direction to ensure that the two sample needles run in opposite directions along a predetermined trajectory to prevent the two sample needles from colliding; third, based on the area between the sample track unit 200, the sample disk unit 170, and the reaction disk unit 150, the two sample needles are innovatively arranged in layout.

The first sample needle can satisfy the need of sampling in the sample disk unit 170 when in a stand-alone mode, and can also satisfy the need of sampling on the sample track unit 200 when in an online mode. There are three main reasons for achieving this effect: First, according to the positional relationship between the sample needle and the sample track unit 200, the sample disk unit 170 and the reaction disk unit 150, the first sample needle is determined to be the sample needle that satisfies the need of sampling from these two points at the same time during the design; second, in terms of structure, the arm length design of the first sample needle satisfies the need of taking samples from both points, and can also satisfy the need of injecting samples at the corresponding position of the reaction disk; third, while the length of the sample needle meets the position function requirements, the stability of the sample needle itself must also be taken into account. Compared with one-point sampling, multi-point sampling will inevitably increase the arm length of the sample needle. The longer the arm length, the greater the inertia and resistance during operation. In addition, due to the strict requirements on the working time of the sample needle, the larger the angle at which the sample needle runs, the greater its acceleration will be. These changes require a more stable sample needle structure to ensure the movement accuracy of the sample needle.

In addition, in order to meet the needs of saccharification testing, the sampling needle part of the sample needle of the present invention is designed to be thinner, and the material selection of the needle part of the sample needle is selected from materials with high comprehensive properties such as hardness, elasticity, and rust resistance, to ensure that the longitudinal anti-collision function of the sample needle will not fail when it touches the bottom for sampling, and that the needle performance will not decrease after long-term use.

The above implementation modes are only used to illustrate the present invention, but not to limit the present invention. Ordinary technicians in the relevant technical field can make various changes and modifications without departing from the spirit and scope of the present invention. Therefore, all equivalent technical solutions also belong to the scope of the present invention. The patent protection scope of the present invention should be defined by the claims.

Claims (13)

1. A fully automatic high-speed biochemical analyzer, characterized in that it comprises: The reaction tray unit is used to load the reaction cups and transport the reaction cups to the corresponding working positions for performing corresponding analysis operations; The reaction cup automatic cleaning unit is used to automatically clean the reaction cup that has reached the cleaning position; A mixing unit, located next to the stirring position, is used to stir the mixed solution in the reaction cup located on the stirring position after adding the sample and/or reagent; An optical detection unit, including a transmission module and a scattering module, is used to perform optical detection on the reactants in the reaction cup; The reagent disk unit is located on the left side of the reaction disk unit and is used to load reagent bottles of different specifications and transport the reagent bottles to the reagent suction position to cooperate with the reagent needle unit to suck the reagent; The reagent needle unit is located between the reagent disk unit and the reaction disk unit, and is mainly used to draw a specified amount of reagent from the reagent bottle and inject the reagent into the reaction cup located at the reagent adding position; An automatic reagent loading and unloading unit is arranged above the reagent tray unit, and automatically grabs reagent bottles from the track and places them in the reagent tray unit, or grabs reagent bottles in the reagent tray unit that are not to be tested by the instrument and places them on the track; The sample tray unit is located on the right side of the reaction tray unit and is used to load and transport samples or quality control products, transport the sample tube to the sample suction position, and cooperate with the sample needle unit to suck the sample; the sample tray unit is mainly used for single-machine sampling; The sample track unit includes at least one sample tube transport track, which is used to transport sample tubes from the sample centralized management area to the sampling position, and cooperates with the sample needle unit to absorb samples. The sample track unit is mainly used for online sampling, including being connected to the sample centralized management area or other automated testing instruments; The sample needle unit is located in a triangular area formed by the reaction disk unit, the sample disk unit and the sample track unit; the sample needle unit includes two sample needles with different arm lengths, and the two sample needles take samples at the same point of the sample track unit; the sample needle with a longer arm length is used to take samples on the sample disk unit or the sample track unit. 2. A fully automatic high-speed biochemical analyzer as described in claim 1, characterized in that: the biochemical analyzer also includes an ultrasonic cleaning module, a saccharification cleaning tank and an ISE unit; the ultrasonic cleaning module is located between the sample disk unit and the sample track unit, and is on the running route of the sample needle, and is used to deeply clean the sample needle; the saccharification cleaning tank is located between the reaction disk unit and the sample track unit, and is on the running route of the sample needle, and is used to clean the sample needle after the saccharification item test; the ISE unit is composed of Na ⁺ , K ⁺ , Cl ^- selective electrodes, a reference electrode, an injection and measurement channel, a syringe, a thermal stabilization unit, a degassing unit and a waste liquid discharge component. 3. A fully automatic high-speed biochemical analyzer as described in claim 1, characterized in that: the reaction disk unit includes a reaction disk assembly, a reaction cup, and a constant temperature assembly; the reaction cup is placed in the reaction disk assembly, the reaction disk assembly is driven by a two-stage transmission method, and the constant temperature assembly provides a constant temperature environment for the reaction in the reaction cup by water bath heating. 4. A fully automatic high-speed biochemical analyzer as described in claim 1, characterized in that: the automatic cleaning unit of the reaction cup includes a cleaning needle, a lifting motor and related liquid circuits; the lifting motor controls the cleaning needle to rise and fall, and automatically completes the cleaning of the reaction cup. 5. A fully automatic high-speed biochemical analyzer as described in claim 1, characterized in that: the mixing unit is distributed around the reaction disk unit, and the mixing unit adopts a three-head mixing stirring head design, and the mixed liquid in the reaction cup is stirred by combining the mechanical reciprocating motion of the stirring head with the rotary stirring. 6. A fully automatic high-speed biochemical analyzer as described in claim 1, characterized in that: in the optical detection unit, the transmission module is located on one side of the reaction disk unit, the detection optical axis of the transmission module is perpendicular to the reaction cup to be detected, and is used to test most biochemical items; the scattering module is located on the other side of the reaction disk unit, the detection optical axis of the scattering module is perpendicular to the reaction cup to be detected, and forms a certain pitch angle with the reactants in the reaction cup in the horizontal direction, specifically located in the triangular area formed by the reaction disk unit, the sample needle unit and the mixing unit, and is used to test low-concentration biochemical items. 7. A fully automatic high-speed biochemical analyzer as described in claim 1, characterized in that: the reagent disc unit includes a reagent disc assembly with a disc-type structure design, the reagent disc assembly includes an inner ring and an outer ring that are independently rotationally controlled, and the inner ring and the outer ring are respectively equipped with different reagent needle units for interactive liquid extraction; the reagent disc assembly has a 24-hour uninterrupted refrigeration function; the reagent barcode scanning assembly is used to automatically obtain reagent information; the reagent disc assembly adopts a tensioning adjustable mechanism, two sets of synchronous belts and a stepper motor drive structure, has the freedom of rotation in one direction along the vertical direction, and can achieve forward and reverse rotation through motor control. 8. A fully automatic high-speed biochemical analyzer as described in claim 1, characterized in that: the reagent needle unit is mainly composed of a reagent needle, a reagent needle rocker arm, a reagent needle drive shaft, a reagent syringe, a reagent needle cleaning tank and related liquid circuits; each of the reagent disk units is equipped with two sets of reagent needle units with opposite movement directions; the reagent needle unit has anti-collision protection functions in both horizontal and vertical directions; the reagent needle unit has liquid level detection, volume tracking and empty suction alarm functions. 9. A fully automatic high-speed biochemical analyzer as described in claim 1, characterized in that: the automatic reagent loading and unloading unit includes a horizontal rail, a vertical rail and a human-machine reagent exchange platform; the horizontal rail is responsible for horizontal movement, and the vertical rail is responsible for vertical movement, so as to realize taking out an empty reagent bottle from a specified position of the reagent disk unit to the human-machine reagent exchange platform, and taking a reagent bottle from the human-machine reagent exchange platform and putting it into a specified position of the reagent disk unit. 10. A fully automatic high-speed biochemical analyzer as described in claim 1, characterized in that: the sample tray unit includes a sample tray assembly with a disc-type structure design; the sample tray assembly has a refrigeration function, which is used to perform low-temperature temperature control on samples or quality control products in the central area; the sample barcode scanning assembly is used to automatically obtain sample information; the sample tray assembly adopts a tensioning adjustable mechanism, two sets of synchronous belts and a stepper motor drive structure, has the freedom to rotate in one direction along the vertical direction, and can achieve forward and reverse rotation through motor control. 11. A fully automatic high-speed biochemical analyzer as described in claim 1, characterized in that: when the sample track unit is in an online state, the sample tube moves from left to right or from right to left driven by the sample tube transport track; when the sample tube reaches the sampling point along the sample tube transport track, both sample needles can move to the same sampling point for sampling. 12. A fully automatic high-speed biochemical analyzer as described in claim 1, characterized in that: the sample needle unit is mainly composed of a sample needle, a sample needle rocker arm, a sample needle drive shaft, a sample syringe, a sample needle cleaning tank and related liquid circuits; the sample needle unit has anti-collision protection functions in both horizontal and vertical directions; the sample needle unit has liquid level detection and quantity tracking functions. 13. A fully automatic high-speed biochemical analyzer as described in claim 12, characterized in that: the sample needle includes a first sample needle and a second sample needle, the arm length of the first sample needle is greater than the arm length of the second sample needle; the first sample needle is located at the right part of the sample needle unit, close to the sample disk unit, and the second sample needle is located at the left part of the sample needle unit, close to the reaction disk unit; the first sample needle meets the requirements of sampling in the sample disk unit when the machine is stand-alone and in the sample track unit when the machine is online.