CN118477145A - Gastrodia elata compound composition for treating dizziness and preparation method thereof - Google Patents
Gastrodia elata compound composition for treating dizziness and preparation method thereof Download PDFInfo
- Publication number
- CN118477145A CN118477145A CN202410634638.4A CN202410634638A CN118477145A CN 118477145 A CN118477145 A CN 118477145A CN 202410634638 A CN202410634638 A CN 202410634638A CN 118477145 A CN118477145 A CN 118477145A
- Authority
- CN
- China
- Prior art keywords
- parts
- gastrodia elata
- compound composition
- dizziness
- treating dizziness
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000002173 dizziness Diseases 0.000 title claims abstract description 69
- 241000305491 Gastrodia elata Species 0.000 title claims abstract description 35
- 239000000203 mixture Substances 0.000 title claims abstract description 34
- 150000001875 compounds Chemical class 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 206010062717 Increased upper airway secretion Diseases 0.000 claims abstract description 29
- 208000026435 phlegm Diseases 0.000 claims abstract description 29
- 210000004185 liver Anatomy 0.000 claims abstract description 17
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 14
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 14
- 235000008434 ginseng Nutrition 0.000 claims abstract description 14
- 240000000249 Morus alba Species 0.000 claims abstract description 13
- 235000008708 Morus alba Nutrition 0.000 claims abstract description 13
- 208000013403 hyperactivity Diseases 0.000 claims abstract description 13
- 235000002722 Dioscorea batatas Nutrition 0.000 claims abstract description 12
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims abstract description 12
- 240000001811 Dioscorea oppositifolia Species 0.000 claims abstract description 12
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims abstract description 12
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 10
- 241000045403 Astragalus propinquus Species 0.000 claims abstract description 8
- 235000006533 astragalus Nutrition 0.000 claims abstract description 8
- 244000241838 Lycium barbarum Species 0.000 claims abstract description 3
- 235000015459 Lycium barbarum Nutrition 0.000 claims abstract description 3
- 235000015468 Lycium chinense Nutrition 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 30
- 239000000284 extract Substances 0.000 claims description 25
- 239000003814 drug Substances 0.000 claims description 24
- 239000000843 powder Substances 0.000 claims description 15
- 241001522129 Pinellia Species 0.000 claims description 12
- 244000183685 Citrus aurantium Species 0.000 claims description 11
- 235000007716 Citrus aurantium Nutrition 0.000 claims description 11
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims description 11
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims description 11
- 235000009685 Crataegus X maligna Nutrition 0.000 claims description 11
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims description 11
- 235000009486 Crataegus bullatus Nutrition 0.000 claims description 11
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims description 11
- 235000009682 Crataegus limnophila Nutrition 0.000 claims description 11
- 240000000171 Crataegus monogyna Species 0.000 claims description 11
- 235000004423 Crataegus monogyna Nutrition 0.000 claims description 11
- 235000002313 Crataegus paludosa Nutrition 0.000 claims description 11
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims description 11
- 241000207925 Leonurus Species 0.000 claims description 11
- 235000004347 Perilla Nutrition 0.000 claims description 11
- 244000124853 Perilla frutescens Species 0.000 claims description 11
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 235000017784 Mespilus germanica Nutrition 0.000 claims description 10
- 235000000560 Mimusops elengi Nutrition 0.000 claims description 10
- 235000007837 Vangueria infausta Nutrition 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 10
- 238000010298 pulverizing process Methods 0.000 claims description 10
- 235000006484 Paeonia officinalis Nutrition 0.000 claims description 9
- 241001106477 Paeoniaceae Species 0.000 claims description 9
- 241000112528 Ligusticum striatum Species 0.000 claims description 8
- 240000005001 Paeonia suffruticosa Species 0.000 claims description 8
- 235000003889 Paeonia suffruticosa Nutrition 0.000 claims description 8
- 239000000706 filtrate Substances 0.000 claims description 8
- 241000217407 Margaritifera Species 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000002552 dosage form Substances 0.000 claims description 2
- 241000208340 Araliaceae Species 0.000 claims 3
- 244000088415 Raphanus sativus Species 0.000 claims 3
- 244000182216 Mimusops elengi Species 0.000 claims 2
- 210000004369 blood Anatomy 0.000 abstract description 19
- 239000008280 blood Substances 0.000 abstract description 19
- 210000000952 spleen Anatomy 0.000 abstract description 10
- 230000001737 promoting effect Effects 0.000 abstract description 7
- 210000002784 stomach Anatomy 0.000 abstract description 7
- 230000017531 blood circulation Effects 0.000 abstract description 4
- 230000017423 tissue regeneration Effects 0.000 abstract description 4
- 230000001717 pathogenic effect Effects 0.000 abstract description 3
- 238000005728 strengthening Methods 0.000 abstract description 3
- 230000003213 activating effect Effects 0.000 abstract 2
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 230000001914 calming effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 15
- 208000024891 symptom Diseases 0.000 description 12
- 230000007812 deficiency Effects 0.000 description 11
- 240000004371 Panax ginseng Species 0.000 description 10
- 208000012886 Vertigo Diseases 0.000 description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 10
- 231100000889 vertigo Toxicity 0.000 description 9
- 240000002624 Mespilus germanica Species 0.000 description 8
- 241000220259 Raphanus Species 0.000 description 8
- 201000010099 disease Diseases 0.000 description 8
- 229940079593 drug Drugs 0.000 description 7
- 241000489492 Arisaema Species 0.000 description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
- 238000009825 accumulation Methods 0.000 description 6
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 5
- 241000305492 Gastrodia Species 0.000 description 5
- 206010020772 Hypertension Diseases 0.000 description 5
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 description 5
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 5
- 229940107666 astragalus root Drugs 0.000 description 5
- 210000003128 head Anatomy 0.000 description 5
- 206010022437 insomnia Diseases 0.000 description 5
- 241000700199 Cavia porcellus Species 0.000 description 4
- 206010019233 Headaches Diseases 0.000 description 4
- 241000212322 Levisticum officinale Species 0.000 description 4
- 208000009205 Tinnitus Diseases 0.000 description 4
- 231100000869 headache Toxicity 0.000 description 4
- 208000034783 hypoesthesia Diseases 0.000 description 4
- 239000001645 levisticum officinale Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 206010029864 nystagmus Diseases 0.000 description 4
- 231100000886 tinnitus Toxicity 0.000 description 4
- 241000700198 Cavia Species 0.000 description 3
- 208000000059 Dyspnea Diseases 0.000 description 3
- 206010013975 Dyspnoeas Diseases 0.000 description 3
- 206010044565 Tremor Diseases 0.000 description 3
- 206010047700 Vomiting Diseases 0.000 description 3
- 210000000133 brain stem Anatomy 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 210000003414 extremity Anatomy 0.000 description 3
- 206010016256 fatigue Diseases 0.000 description 3
- 231100000862 numbness Toxicity 0.000 description 3
- 208000013220 shortness of breath Diseases 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 230000001720 vestibular Effects 0.000 description 3
- 208000000044 Amnesia Diseases 0.000 description 2
- 208000031091 Amnestic disease Diseases 0.000 description 2
- 206010063659 Aversion Diseases 0.000 description 2
- 208000004044 Hypesthesia Diseases 0.000 description 2
- 206010022998 Irritability Diseases 0.000 description 2
- 208000002720 Malnutrition Diseases 0.000 description 2
- 206010033557 Palpitations Diseases 0.000 description 2
- 206010041591 Spinal osteoarthritis Diseases 0.000 description 2
- 206010047513 Vision blurred Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000006986 amnesia Effects 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 208000036319 cervical spondylosis Diseases 0.000 description 2
- 239000010135 fructus aurantii immaturus Substances 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000003127 knee Anatomy 0.000 description 2
- 230000001071 malnutrition Effects 0.000 description 2
- 235000000824 malnutrition Nutrition 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 208000015380 nutritional deficiency disease Diseases 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 235000019615 sensations Nutrition 0.000 description 2
- 208000005801 spondylosis Diseases 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 1
- 241000185686 Apocynum venetum Species 0.000 description 1
- 241000132012 Atractylodes Species 0.000 description 1
- 208000001573 Cataplexy Diseases 0.000 description 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 241000241550 Cyathula Species 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 235000002723 Dioscorea alata Nutrition 0.000 description 1
- 235000007056 Dioscorea composita Nutrition 0.000 description 1
- 235000009723 Dioscorea convolvulacea Nutrition 0.000 description 1
- 235000005362 Dioscorea floribunda Nutrition 0.000 description 1
- 235000004868 Dioscorea macrostachya Nutrition 0.000 description 1
- 235000005361 Dioscorea nummularia Nutrition 0.000 description 1
- 235000005360 Dioscorea spiculiflora Nutrition 0.000 description 1
- 206010014020 Ear pain Diseases 0.000 description 1
- 241000402754 Erythranthe moschata Species 0.000 description 1
- 208000032974 Gagging Diseases 0.000 description 1
- 244000111489 Gardenia augusta Species 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 239000009636 Huang Qi Substances 0.000 description 1
- 206010020710 Hyperphagia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 235000006350 Ipomoea batatas var. batatas Nutrition 0.000 description 1
- 206010024642 Listless Diseases 0.000 description 1
- 241000361919 Metaphire sieboldi Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241001080798 Polygala tenuifolia Species 0.000 description 1
- 244000046146 Pueraria lobata Species 0.000 description 1
- 235000010575 Pueraria lobata Nutrition 0.000 description 1
- 206010040026 Sensory disturbance Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 244000228451 Stevia rebaudiana Species 0.000 description 1
- 235000006092 Stevia rebaudiana Nutrition 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 208000030886 Traumatic Brain injury Diseases 0.000 description 1
- 241000157352 Uncaria Species 0.000 description 1
- 206010047571 Visual impairment Diseases 0.000 description 1
- 208000031975 Yang Deficiency Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000007244 Zea mays Nutrition 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000003276 anti-hypertensive effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229940116229 borneol Drugs 0.000 description 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 229940089639 cornsilk Drugs 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 235000004879 dioscorea Nutrition 0.000 description 1
- 229960003520 diphenidol Drugs 0.000 description 1
- OGAKLTJNUQRZJU-UHFFFAOYSA-N diphenidol Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(O)CCCN1CCCCC1 OGAKLTJNUQRZJU-UHFFFAOYSA-N 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 1
- 210000003027 ear inner Anatomy 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000000763 evoking effect Effects 0.000 description 1
- 208000027993 eye symptom Diseases 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 208000018997 giddiness Diseases 0.000 description 1
- 229940095686 granule product Drugs 0.000 description 1
- 244000237330 gutta percha tree Species 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 208000017971 listlessness Diseases 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 235000020830 overeating Nutrition 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 201000006302 peripheral vertigo Diseases 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000272 proprioceptive effect Effects 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 210000002385 vertebral artery Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000001231 zea mays silk Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8884—Arisaema, e.g. Jack in the pulpit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Otolaryngology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a gastrodia elata compound composition for treating dizziness, which is prepared from, by weight, 30-50 parts of gastrodia elata, 20-30 parts of ginseng, 15-25 parts of astragalus mongholicus, 18-22 parts of wolfberry fruit, 20-30 parts of Chinese yam, 15-25 parts of sea-ear shell, 20-30 parts of mulberry leaf and the like, and the preparation method of the gastrodia elata compound composition is used for jointly treating dizziness caused by liver yang hyperactivity due to turbid phlegm by tonifying qi and blood, strengthening spleen and stomach, calming liver and suppressing yang, clearing pathogenic fire and expelling wind, eliminating dampness and eliminating phlegm, removing stasis and promoting tissue regeneration, activating blood circulation and dredging collaterals, strengthening spleen and promoting transportation, and activating stomach qi.
Description
Technical Field
The invention relates to a gastrodia elata compound composition for treating dizziness and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines.
Background
Dizziness is a subjective sensory disturbance that a patient feels himself or herself rotating or swaying in the environment. It can be classified into rotability and non-rotability, and can be classified into spontaneity and inducibility. Rotary vertigo includes rotation, tumbling sensations of the body itself or the surrounding environment, while non-rotary vertigo includes rocking, tilting, drifting, sliding sensations. Common causes of vertigo include disease factors (e.g., vestibular peripheral vertigo and vestibular central vertigo), pharmaceutical factors, environmental factors, and lifestyle. Specific groups such as the elderly or persons with diseases of the visual system, vestibular organ and proprioceptive system are more prone to vertigo.
Dizziness is regarded as a general term of dizziness and dizziness by traditional Chinese medicine, and dizziness is regarded as dizziness due to blurred vision and darkness; the traditional Chinese medicine compound composition for treating the hypertension dizziness is characterized by dialectical treatment of the traditional Chinese medicine treatment diseases, so that the treatment of the dizziness also needs dialectical treatment, and different treatment means CN117679476A are disclosed for treating the dizziness with various symptoms. The traditional Chinese medicine compound composition for treating hypertension dizziness comprises the following raw materials in parts by weight: 30-120 parts of calcined magnetite, 15-60 parts of eucommia ulmoides, 20-180 parts of gastrodia elata, 15-120 parts of apocynum venetum leaves, 10-40 parts of medicinal cyathula root, 8-30 parts of rhizoma pinellinae praeparata, 15-120 parts of stir-fried bighead atractylodes rhizome, 10-120 parts of rhizoma alismatis, 30-120 parts of kudzuvine root, 10-60 parts of corn silk and 10-40 parts of stevia rebaudiana. The traditional Chinese medicine compound composition has good antihypertensive curative effect on patients with hypertension dizziness, can obviously improve clinical symptoms of dizziness, blurred vision, tinnitus, bitter taste, nausea and vomiting, limb numbness, vexation and insomnia of patients with hypertension dizziness, has definite curative effect on treating hypertension dizziness (wind phlegm disturbance syndrome), and is safe and reliable to use. CN116459315A discloses a traditional Chinese medicine composition for treating dizziness caused by cervical spondylosis and application thereof. The composition is prepared from the following raw materials in parts by weight: 10-20 parts of gastrodia elata, 10-20 parts of bubali, 10-30 parts of ligusticum wallichii, 10-20 parts of earthworm, 10-15 parts of musk, 20-30 parts of notopterygium root, 10-20 parts of polygala tenuifolia, 20-25 parts of borneol, 20-40 parts of rhizoma acori graminei and 10-15 parts of gardenia. The composition can be used as filling component of medicated pillow to make medicated pillow. The traditional Chinese medicine composition and the traditional Chinese medicine pillow prepared by the traditional Chinese medicine composition have good treatment effect on dizziness symptoms caused by cervical spondylosis, and have good application prospects. The composition aims at dizziness caused by diseases, does not occur from the treatment method of traditional Chinese medicine, and analyzes the cause caused by the dizziness, so that the composition has narrow adaptation range and is not beneficial to the treatment of the dizziness diseases.
Disclosure of Invention
The invention aims to provide a gastrodia elata compound composition for treating dizziness and a preparation method thereof. The invention aims at dizziness caused by liver yang hyperactivity due to turbid phlegm and internal accumulation according to the therapeutic rules of the traditional Chinese medicine, has obvious medicinal effect and good clinical curative effect.
In order to solve the technical problems, the invention is realized by adopting the following technical scheme: the gastrodia elata compound composition for treating dizziness is prepared from, by weight, 30-50 parts of gastrodia elata, 20-30 parts of ginseng, 15-25 parts of astragalus membranaceus, 18-22 parts of wolfberry fruit, 20-30 parts of Chinese yam, 15-25 parts of concha haliotidis, 20-30 parts of mulberry leaf, 15-25 parts of mother-of-pearl, 18-22 parts of dried orange peel, 20-30 parts of pinellia ternate, 10-20 parts of arisaema tuber, 15-25 parts of rhizoma atractylodis, 20-30 parts of motherwort herb, 18-22 parts of red paeony root, 20-30 parts of tree peony bark, 18-22 parts of ligusticum wallichii, 25-35 parts of hawthorn fruit, 20-30 parts of radish seed, 18-22 parts of immature bitter orange and 20-30 parts of perilla seed.
The gastrodia elata compound composition for treating dizziness is prepared from 40 parts of gastrodia elata, 25 parts of ginseng, 20 parts of astragalus membranaceus, 20 parts of medlar, 25 parts of Chinese yam, 20 parts of concha haliotidis, 25 parts of mulberry leaves, 20 parts of mother-of-pearl, 20 parts of dried orange peel, 25 parts of pinellia ternate, 15 parts of rhizoma arisaematis, 20 parts of rhizoma atractylodis, 25 parts of leonurus, 20 parts of radix paeoniae rubra, 25 parts of cortex moutan, 20 parts of ligusticum wallichii, 30 parts of hawthorn, 25 parts of radish seed, 20 parts of immature bitter orange and 25 parts of perilla seed.
The gastrodia elata compound composition for treating dizziness is prepared from, by weight, 30 parts of gastrodia elata, 20 parts of ginseng, 25 parts of astragalus membranaceus, 18 parts of medlar, 30 parts of Chinese yam, 25 parts of concha haliotidis, 20 parts of mulberry leaves, 25 parts of mother-of-pearl, 18 parts of dried orange peel, 30 parts of pinellia ternate, 10 parts of rhizoma arisaematis, 25 parts of rhizoma atractylodis, 20 parts of leonurus, 22 parts of radix paeoniae rubra, 20 parts of cortex moutan, 22 parts of ligusticum wallichii, 25 parts of hawthorn, 30 parts of radish seeds, 18 parts of immature bitter oranges and 30 parts of perilla seeds.
The gastrodia elata compound composition for treating dizziness is prepared from 50 parts of gastrodia elata, 30 parts of ginseng, 15 parts of astragalus membranaceus, 22 parts of medlar, 20 parts of Chinese yam, 15 parts of concha haliotidis, 30 parts of mulberry leaves, 15 parts of mother-of-pearl, 22 parts of dried orange peel, 20 parts of pinellia ternate, 20 parts of rhizoma arisaematis, 15 parts of rhizoma atractylodis, 30 parts of leonurus, 18 parts of red paeony root, 30 parts of cortex moutan, 18 parts of ligusticum wallichii, 35 parts of hawthorn, 20 parts of radish seeds, 22 parts of immature bitter orange and 30 parts of perilla.
The preparation method of the gastrodia elata compound composition for treating dizziness comprises the following steps:
(1) Decocting Concha Haliotidis and Concha Margaritifera with ten times of water for 1-3 hr, adding other Chinese medicinal materials, adding water ten times of all materials, decocting for 2 times and 2 hr each time, mixing decoctions, filtering, concentrating the filtrate to obtain extract with relative density of 1.10 at 80deg.C;
(2) Adding ethanol to make the ethanol content reach 50% -75%, continuously stirring, standing for 12-48 hr, filtering, recovering ethanol under reduced pressure to clean, concentrating to obtain extract with relative density of 1.05-1.10 at 50deg.C, drying, and pulverizing into dry extract powder to obtain dry extract powder;
(3) Pulverizing the dry extract powder, adding adjuvants, and making into pharmaceutical preparation.
The gastrodia elata compound composition for treating dizziness has the advantage that the dosage form of the pharmaceutical preparation is one of tablets, capsules and granules.
The application of the gastrodia elata compound composition for treating dizziness in preparing medicines for treating dizziness.
The application of the gastrodia elata compound composition for treating dizziness in preparing a medicine for treating dizziness belongs to liver-yang hyperactivity caused by turbid phlegm in the body.
Vertigo is recurrent and the course of the disease is longer, and usually the deficiency of the root causes is marked by the excess and excess, and usually the deficiency and excess are transformed. If the disease is in the early stage of onset, the disease is usually manifested as excessive syndrome, i.e. phlegm turbidity with middle energizer, blood stasis with internal resistance, or liver yang hyperactivity due to yin-yang imbalance, and if it is not healed for a long time, it can be transformed into deficiency syndrome of qi and blood deficiency and kidney essence deficiency; it is also manifested as dizziness due to deficiency of qi and blood and deficiency of kidney essence, repeated attacks, unsmooth qi-blood-body fluids running, and phlegm turbidity with blood stasis, which is accompanied by deficiency and excess. For the stagnation of turbid phlegm, the excessive upward movement of liver yang or the upward disturbance of turbid phlegm due to the stagnation of phlegm and transformation of fire can be translated into the excessive upward movement of liver yang; because of the accumulation of turbid phlegm, qi and blood are repressed, and phlegm and blood stasis can be caused in a long time. The most common is the hyperactivity of liver-yang due to turbid phlegm.
Based on the principle of treating both principal and secondary aspect of disease, the symptoms of hyperactivity of liver yang caused by turbid phlegm in the body are often caused in the elderly and weak patients, and the symptoms of deficiency of qi and blood and malnutrition of the brain are as follows: vertigo, sudden movement, fatigue, shortness of breath, pale complexion, tinnitus, headache, irritability, insomnia and dreaminess, slippery or wiry pulse, or soreness of the waist and knees, amnesia, dizziness, aversion to vomiting, headache such as tug, limb numbness and tremors, unfavorable language, and walking. Because of deficiency of qi and blood, listlessness and lazy speaking, pale complexion, deficiency of spleen and lung qi, shortness of breath, heart-mind malnutrition, palpitation and insomnia, qi and blood are firstly tonified, and spleen and stomach are healthy; in addition, liver yang hyperactivity is manifested as top-up, so dizziness, tinnitus, wiry pulse, need to calm liver, subdue yang, clear fire and stop wind; meanwhile, turbid phlegm obstructing the middle energizer and clearing orifices, so dizziness; phlegm is accumulation of dampness, heavy turbidity of dampness and repression of clear yang, so lassitude and heavy head are as good as one; turbid phlegm obstructing the middle energizer and causing adverse qi movement, chest distress; for yang deficiency failing to transform water, cold-retained fluid failing to flow upwards and over-center, palpitations due to heart down-flow, dry dampness and eliminate phlegm. At the same time, blood stasis blocks collaterals, qi and blood cannot flow normally, brain fails to nourish, so the medicine is used for treating dizziness, and is required to remove blood stasis, promote tissue regeneration, promote blood circulation and remove meridian obstruction. The stomach qi is reversed, so that phlegm and saliva are spitted; spleen yang is the repression of phlegm-dampness and not vibrating, so the symptoms of overeating and insomnia are all symptoms of phlegm-dampness accumulation, and spleen strengthening, transportation assisting, stomach qi dredging and descending are also needed.
The invention adopts ginseng, astragalus root, medlar and yam to invigorate qi and blood, strengthen spleen and stomach, tall gastrodia tuber, sea-ear shell, mulberry leaf and mother-of-pearl to calm liver and suppress yang, clear fire and stop wind, and are all monarch drugs; dried orange peel, pinellia tuber, arisaema tuber and rhizoma atractylodis are used as ministerial drugs for eliminating dampness and eliminating phlegm; herba Leonuri, radix Paeoniae Rubra, cortex moutan, and rhizoma Ligustici Chuanxiong with effects of removing blood stasis, promoting tissue regeneration, promoting blood circulation, and dredging collaterals as adjuvant drugs; fructus crataegi, raphani semen, fructus Aurantii Immaturus, su Zijian and spleen assist transportation, and remove gastric qi, and the whole formula contains Ginseng radix, radix astragali, fructus Lycii, rhizoma Dioscoreae, rhizoma Gastrodiae, concha Haliotidis, folium Mori, concha Margaritifera, pericarpium Citri Tangerinae, rhizoma Pinelliae, rhizoma arisaematis, rhizoma Atractylodis, herba Leonuri, radix Paeoniae Rubra, cortex moutan, rhizoma Ligustici Chuanxiong, fructus crataegi, raphani semen, fructus Aurantii Immaturus, and fructus Perillae, and can be used for treating giddiness due to liver yang hyperactivity caused by turbid phlegm by invigorating qi and blood, nourishing spleen and stomach, suppressing hyperactive liver yang, clearing pathogenic fire and expelling pathogenic wind, eliminating dampness and phlegm, removing blood stasis and promoting tissue regeneration, promoting blood circulation and removing obstruction in collaterals, invigorating spleen and promoting transportation, and removing gastric qi.
Detailed Description
The application is further described below in conjunction with the detailed description. It is to be understood that these examples are illustrative of the present application and are not intended to limit the scope of the present application. Further, it is understood that various changes and modifications of the present application may be made by those skilled in the art after reading the description of the present application, and that such equivalents are intended to fall within the scope of the application as defined in the appended claims.
Example 1: 40g of gastrodia tuber, 25g of ginseng, 20g of astragalus root, 20g of medlar, 25g of Chinese yam, 20g of concha haliotidis, 25g of mulberry leaf, 20g of mother-of-pearl, 20g of dried orange peel, 25g of pinellia tuber, 15g of arisaema tuber, 20g of rhizoma atractylodis, 25g of motherwort herb, 20g of red paeony root, 25g of tree peony bark, 20g of szechuan lovage rhizome, 30g of hawthorn fruit, 25g of radish seed, 20g of immature bitter orange and 25g of perilla seed, and the preparation method comprises the following steps:
(1) Decocting Concha Haliotidis and Concha Margaritifera with ten times of water for 2 hr, adding other Chinese medicinal materials, adding water ten times of all materials, decocting for 2 times and 2 hr each time, mixing decoctions, filtering, concentrating the filtrate to obtain extract with relative density of 1.10 at 80deg.C;
(2) Adding ethanol to reach ethanol content of 65%, stirring, standing for 36 hr, filtering, recovering ethanol from filtrate under reduced pressure to clean and concentrating to obtain extract with relative density of 1.08 at 50deg.C, drying, and pulverizing into dry extract powder to obtain dry extract powder;
(3) Pulverizing the dry extract powder, adding dextrin, and making into granule.
Example 2: 40g of gastrodia tuber, 25g of ginseng, 20g of astragalus root, 20g of medlar, 25g of Chinese yam, 20g of concha haliotidis, 25g of mulberry leaf, 20g of mother-of-pearl, 20g of dried orange peel, 25g of pinellia tuber, 15g of arisaema tuber, 20g of rhizoma atractylodis, 25g of motherwort herb, 20g of red paeony root, 25g of tree peony bark, 20g of szechuan lovage rhizome, 30g of hawthorn fruit, 25g of radish seed, 20g of immature bitter orange and 25g of perilla seed, and the preparation method comprises the following steps:
(1) Decocting Concha Haliotidis and Concha Margaritifera with ten times of water for 1 hr, adding other Chinese medicinal materials, adding water ten times of all materials, decocting for 2 times and 2 hr each time, mixing decoctions, filtering, concentrating the filtrate to obtain extract with relative density of 1.10 at 80deg.C;
(2) Adding ethanol to make ethanol content reach 75%, continuously stirring, standing for 12 hr, filtering, recovering ethanol from filtrate under reduced pressure to clean and concentrating to extract with relative density of 1.10 at 50deg.C, drying the extract, and pulverizing into dry extract powder to obtain dry extract powder;
(3) Pulverizing the dry extract powder, adding starch, and making into tablet.
Example 3: 40g of gastrodia tuber, 25g of ginseng, 20g of astragalus root, 20g of medlar, 25g of Chinese yam, 20g of concha haliotidis, 25g of mulberry leaf, 20g of mother-of-pearl, 20g of dried orange peel, 25g of pinellia tuber, 15g of arisaema tuber, 20g of rhizoma atractylodis, 25g of motherwort herb, 20g of red paeony root, 25g of tree peony bark, 20g of szechuan lovage rhizome, 30g of hawthorn fruit, 25g of radish seed, 20g of immature bitter orange and 25g of perilla seed, and the preparation method comprises the following steps:
(1) Decocting Concha Haliotidis and Concha Margaritifera with ten times of water for 3 hr, adding other Chinese medicinal materials, adding water ten times of all materials, decocting for 2 times and 2 hr each time, mixing decoctions, filtering, concentrating the filtrate to obtain extract with relative density of 1.10 at 80deg.C;
(2) Adding ethanol to make the ethanol content reach 50%, continuously stirring, standing for 48 hr, filtering, recovering ethanol from filtrate under reduced pressure to clean and concentrating to extract with relative density of 1.05 at 50deg.C, drying the extract, and pulverizing into dry extract powder to obtain dry extract powder;
(3) Pulverizing the dry extract powder, adding microcrystalline cellulose, and making into capsule.
Example 4: the invention tests the dizziness caused by the guinea pig chloroform
Taking qualified guinea pigs, wherein the male and female parts are half, the quality of the guinea pigs is 250-300 g, the guinea pigs are randomly divided into 5 groups, namely a control group, the groups (10 g/kg) of the embodiment 1-3 of the invention, the groups (12.5 mg/kg) of the difenidol hydrochloride serving as a positive drug, 10 animals in each group, and the corresponding drugs are given to each group, wherein the administration volume is 10mL/kg, 1 time a day and 14 times a total administration. The last administration was carried out for 30min, 15. Mu.L of chloroform was dropped from the right ear of guinea pig, and the latency and duration of appearance of nystagmus were observed, the duration being bounded by 60min, and the results are shown in Table 1.
TABLE 1 Effect of the invention on chloroform-induced guinea pig nystagmus latency and duration of tremor (x+ -s, n=10)
Comparison to the control group: *P<0.05,** P is less than 0.01
As can be seen from Table 1, the groups of examples 1-3 of the present invention significantly prolonged guinea pig nystagmus latency and shortened nystagmus duration, and the differences were significant (P < 0.05, 0.01) compared with the control group, and the effects were similar to those of the positive drugs.
Example 5: the invention relates to a clinical curative effect evaluation for treating dizziness caused by liver yang hyperactivity due to turbid phlegm and internal accumulation
1. Case origin: 120 cases of dizziness caused by liver yang hyperactivity due to phlegm accumulation in the patients who visit the patients in 2022, 1 month and 2023, 1 month are selected.
2. Diagnostic criteria: ① Dizziness is a visual disturbance or a sense of rotation of the user, and is often induced by head or body position changes. ② Dizziness, dizziness with other symptoms of transient ischemia such as brainstem, etc., such as eye symptoms, inner ear pain, numbness of limbs, weakness, cataplexy, syncope, etc. ③ The brain stem injury sign such as cornea or pharyngeal reflex decline or disappearance, regulation and auxiliary disorder, spontaneous or inflammation induced after cervical compression of one side vertebral artery, positive pathological reflex and the like ④ are used for measuring blood pressure, blood checking hemoglobin, erythrocyte count and electrocardiogram, electric measurement and hearing, brain stem evoked potential, cervical vertebra x-ray shooting, transcranial Doppler ultrasound and the like, which are helpful for definite diagnosis and conditional ct examination. ⑤ Except for dizziness patients caused by tumor, swelling trauma, brain trauma, blood, cerebral infarction, cerebral hemorrhage, etc.
3. Case selection: (1) meets the diagnosis standard of Western vertigo; (2) Meets the diagnosis standard of dizziness caused by liver yang hyperactivity due to phlegm turbidity in traditional Chinese medicine; the method comprises the following steps: the clinical symptoms are as follows: vertigo, sudden movement, fatigue, shortness of breath, pale complexion, tinnitus, headache, irritability, insomnia and dreaminess, slippery or wiry pulse, or soreness of the waist and knees, amnesia, dizziness, aversion to vomiting, headache such as tug, limb numbness and tremors, unfavorable language, and walking.
4. Efficacy assessment criteria: and (3) healing: the symptoms such as dizziness disappear, and the curative effect index is more than or equal to 90%. The effect is shown: the symptoms such as dizziness and the like are obviously reduced, the head is slightly faint or the dizziness is slight but not accompanied with rotation and shaking sense of the head and the scenery, and the head can normally live and work. The curative effect index is more than or equal to 70 percent and is less than 90 percent. The method is effective: dizziness or dizziness is relieved, only slight rotation or shaking feeling of scenery is accompanied, and life and work are affected although work can be adhered to. The curative effect index is more than or equal to 30 percent and is less than 70 percent. Invalidation: symptoms such as dizziness, dizziness and the like are not improved or aggravated, and the curative effect index is less than 30 percent.
5. The treatment process comprises the following steps: the granule product prepared in the embodiment 1 of the invention (the daily prescription dose is 40g of tall gastrodia tuber, 25g of ginseng, 20g of astragalus root, 20g of medlar, 25g of Chinese yam, 20g of sea-ear shell, 25g of mulberry leaf, 20g of mother-of-pearl, 20g of dried orange peel, 25g of pinellia tuber, 15g of arisaema tuber, 20g of rhizoma atractylodis, 25g of motherwort, 20g of red paeony root, 25g of tree peony bark, 20g of szechuan lovage rhizome, 30g of hawthorn fruit, 25g of radish seed, 20g of immature bitter orange and 25g of perilla seed) is taken for 1 month in 2 bags each time 3 times per day; the control group takes Jiuzhitang Gastrodia elata Uncaria granule (without sucrose) approval document number is national medicine standard character Z51021084, and the production enterprise is Jiuzhitang Jinding medical industry Co., ltd, one bag (10 g) at a time, 3 times a day, and 1 month.
6. The treatment results are shown in Table 2.
Table 2 comparison of two clinical efficacy
Group of | Healing of the wound | Has obvious effect | Effective and effective | Invalidation of | Total effective rate (%) |
Control group | 15 | 14 | 14 | 17 | 71.7 |
Example 1 group | 28 | 13 | 15 | 4 | 93.3 |
7. Conclusion: the clinical efficacy of the two groups is compared, the clinical effective rate of the example 1 group after treatment is 93.3 percent and is obviously higher than that of the control group by 71.7 percent, which proves that the invention has better clinical treatment effect on dizziness caused by liver yang hyperactivity due to turbid phlegm.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. A gastrodia elata compound composition for treating dizziness is characterized in that: the gastrodia elata compound composition is prepared from, by weight, 30-50 parts of gastrodia elata, 20-30 parts of ginseng, 15-25 parts of astragalus membranaceus, 18-22 parts of wolfberry fruit, 20-30 parts of Chinese yam, 15-25 parts of concha haliotidis, 20-30 parts of mulberry leaf, 15-25 parts of mother-of-pearl, 18-22 parts of dried orange peel, 20-30 parts of pinellia ternate, 10-20 parts of rhizoma arisaematis, 15-25 parts of rhizoma atractylodis, 20-30 parts of leonurus, 18-22 parts of red paeony root, 20-30 parts of tree peony bark, 18-22 parts of ligusticum wallichii, 25-35 parts of hawthorn fruit, 20-30 parts of radish seed, 18-22 parts of immature bitter orange and 20-30 parts of perilla fruit.
2. The gastrodia elata compound composition for treating dizziness according to claim 1, wherein: the gastrodia elata compound composition is prepared from 40 parts of gastrodia elata, 25 parts of ginseng, 20 parts of astragalus membranaceus, 20 parts of medlar, 25 parts of Chinese yam, 20 parts of concha haliotidis, 25 parts of mulberry leaves, 20 parts of mother-of-pearl, 20 parts of dried orange peel, 25 parts of pinellia ternate, 15 parts of rhizoma arisaematis, 20 parts of rhizoma atractylodis, 25 parts of leonurus, 20 parts of red paeony root, 25 parts of tree peony bark, 20 parts of ligusticum wallichii, 30 parts of hawthorn, 25 parts of radish seed, 20 parts of immature bitter orange and 25 parts of perilla seed.
3. The gastrodia elata compound composition for treating dizziness according to claim 1, wherein: the gastrodia elata compound composition is prepared from, by weight, 30 parts of gastrodia elata, 20 parts of ginseng, 25 parts of astragalus mongholicus, 18 parts of medlar, 30 parts of Chinese yam, 25 parts of concha haliotidis, 20 parts of mulberry leaf, 25 parts of mother-of-pearl, 18 parts of dried orange peel, 30 parts of pinellia ternate, 10 parts of rhizoma arisaematis, 25 parts of rhizoma atractylodis, 20 parts of leonurus, 22 parts of red paeony root, 20 parts of tree peony bark, 22 parts of ligusticum wallichii, 25 parts of hawthorn, 30 parts of radish seed, 18 parts of immature bitter orange and 30 parts of perilla seed.
4. The gastrodia elata compound composition for treating dizziness according to claim 1, wherein: the preparation method comprises the following steps:
(1) Decocting Concha Haliotidis and Concha Margaritifera with ten times of water for 1-3 hr, adding other Chinese medicinal materials, adding water ten times of all materials, decocting for 2 times and 2 hr each time, mixing decoctions, filtering, concentrating the filtrate to obtain extract with relative density of 1.10 at 80deg.C;
(2) Adding ethanol to make the ethanol content reach 50% -75%, continuously stirring, standing for 12-48 hr, filtering, recovering ethanol under reduced pressure to clean, concentrating to obtain extract with relative density of 1.05-1.10 at 50deg.C, drying, and pulverizing into dry extract powder to obtain dry extract powder;
(3) Pulverizing the dry extract powder, adding adjuvants, and making into pharmaceutical preparation.
5. The gastrodia elata compound composition for treating dizziness according to claim 4, wherein: the dosage form of the pharmaceutical preparation is one of tablets, capsules and granules.
6. The use of the gastrodia elata compound composition for treating dizziness according to claim 1 in preparing a medicament for treating dizziness.
7. The application of the gastrodia elata compound composition for treating dizziness according to claim 1 in preparing a medicament for treating dizziness, which is characterized in that: the pattern of dizziness belongs to the pattern of hyperactivity of liver yang caused by turbid phlegm in the interior.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202410634638.4A CN118477145A (en) | 2024-05-22 | 2024-05-22 | Gastrodia elata compound composition for treating dizziness and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202410634638.4A CN118477145A (en) | 2024-05-22 | 2024-05-22 | Gastrodia elata compound composition for treating dizziness and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN118477145A true CN118477145A (en) | 2024-08-13 |
Family
ID=92192648
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202410634638.4A Pending CN118477145A (en) | 2024-05-22 | 2024-05-22 | Gastrodia elata compound composition for treating dizziness and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN118477145A (en) |
-
2024
- 2024-05-22 CN CN202410634638.4A patent/CN118477145A/en active Pending
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102727779B (en) | Pharmaceutical composition for treating ovarian cysts and preparation method thereof | |
CN104547622A (en) | Traditional Chinese medicine preparation for treating cataract and preparation method of traditional Chinese medicine preparation | |
CN104491236A (en) | Traditional Chinese medicine preparation for treating essential hypertension and preparation method for traditional Chinese medicine preparation | |
CN101204515A (en) | Medicine for insomnia | |
CN101095886B (en) | Chinese traditional medicine for treating heart neurosis and method for preparing the same | |
CN106421432A (en) | Traditional Chinese medicine for treating aged body deficiency syndrome and delaying senescence | |
CN102293964B (en) | Medicine for treating gastric ulcer, and preparation method thereof | |
CN105311492A (en) | Medicine for treating coronary atherosclerotic heart disease | |
CN105596551A (en) | Traditional Chinese medicine composition having asthenopia relieving function and preparation method thereof | |
CN112741890B (en) | Traditional Chinese medicine composition for treating vertigo and preparation method thereof | |
CN104042981A (en) | Medicament for treating postnatal constipation and preparation method thereof | |
CN104367926A (en) | Traditional Chinese medicine preparation for treating predawn diarrhea and preparation method thereof | |
CN118477145A (en) | Gastrodia elata compound composition for treating dizziness and preparation method thereof | |
CN104524479B (en) | A kind of Chinese medicine composition for treating premenstrual syndrome and preparation method thereof | |
CN103920102A (en) | Traditional Chinese medicine for treating primary hypotension | |
CN112451601A (en) | Comprehensive prevention and treatment medicine for middle-aged and elderly chronic diseases | |
CN111388625A (en) | Traditional Chinese medicine composition for regulating and treating blood stasis constitution and preparation and application thereof | |
CN105343688A (en) | Medicine composition for treating myocardial infarction and application thereof | |
CN104958677A (en) | Traditional Chinese medicine preparation for treating membranous nephropathy and preparation method of traditional Chinese medicine preparation | |
CN112386634A (en) | Traditional Chinese medicine composition for treating senile constipation | |
CN117018150B (en) | A Chinese medicine composition with marrow-opening and rehabilitation effects, and its preparation method and application | |
CN117442681B (en) | A Chinese medicine composition for preventing or treating constipation and its preparation method and application | |
CN105920409A (en) | Medicinal preparation for treating Alzheimer disease and application of medicinal preparation | |
CN105796815A (en) | Kidney-reinforcing and bone-strengthening liquor and preparation method thereof | |
CN103845447A (en) | Pure traditional Chinese medicine life-preserving preparation with functions of tonifying qi, tonifying spleen, nourishing liver, nourishing blood and tranquilizing mind by nourishing heart |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination |