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CN118477145A - Gastrodia elata compound composition for treating dizziness and preparation method thereof - Google Patents

Gastrodia elata compound composition for treating dizziness and preparation method thereof Download PDF

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Publication number
CN118477145A
CN118477145A CN202410634638.4A CN202410634638A CN118477145A CN 118477145 A CN118477145 A CN 118477145A CN 202410634638 A CN202410634638 A CN 202410634638A CN 118477145 A CN118477145 A CN 118477145A
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Prior art keywords
parts
gastrodia elata
compound composition
dizziness
treating dizziness
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CN202410634638.4A
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向陈
陈云
和嘉杰
焦慧良
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Yunnan Runcangsheng Technology Co ltd
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Yunnan Runcangsheng Technology Co ltd
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Abstract

The invention discloses a gastrodia elata compound composition for treating dizziness, which is prepared from, by weight, 30-50 parts of gastrodia elata, 20-30 parts of ginseng, 15-25 parts of astragalus mongholicus, 18-22 parts of wolfberry fruit, 20-30 parts of Chinese yam, 15-25 parts of sea-ear shell, 20-30 parts of mulberry leaf and the like, and the preparation method of the gastrodia elata compound composition is used for jointly treating dizziness caused by liver yang hyperactivity due to turbid phlegm by tonifying qi and blood, strengthening spleen and stomach, calming liver and suppressing yang, clearing pathogenic fire and expelling wind, eliminating dampness and eliminating phlegm, removing stasis and promoting tissue regeneration, activating blood circulation and dredging collaterals, strengthening spleen and promoting transportation, and activating stomach qi.

Description

Gastrodia elata compound composition for treating dizziness and preparation method thereof
Technical Field
The invention relates to a gastrodia elata compound composition for treating dizziness and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines.
Background
Dizziness is a subjective sensory disturbance that a patient feels himself or herself rotating or swaying in the environment. It can be classified into rotability and non-rotability, and can be classified into spontaneity and inducibility. Rotary vertigo includes rotation, tumbling sensations of the body itself or the surrounding environment, while non-rotary vertigo includes rocking, tilting, drifting, sliding sensations. Common causes of vertigo include disease factors (e.g., vestibular peripheral vertigo and vestibular central vertigo), pharmaceutical factors, environmental factors, and lifestyle. Specific groups such as the elderly or persons with diseases of the visual system, vestibular organ and proprioceptive system are more prone to vertigo.
Dizziness is regarded as a general term of dizziness and dizziness by traditional Chinese medicine, and dizziness is regarded as dizziness due to blurred vision and darkness; the traditional Chinese medicine compound composition for treating the hypertension dizziness is characterized by dialectical treatment of the traditional Chinese medicine treatment diseases, so that the treatment of the dizziness also needs dialectical treatment, and different treatment means CN117679476A are disclosed for treating the dizziness with various symptoms. The traditional Chinese medicine compound composition for treating hypertension dizziness comprises the following raw materials in parts by weight: 30-120 parts of calcined magnetite, 15-60 parts of eucommia ulmoides, 20-180 parts of gastrodia elata, 15-120 parts of apocynum venetum leaves, 10-40 parts of medicinal cyathula root, 8-30 parts of rhizoma pinellinae praeparata, 15-120 parts of stir-fried bighead atractylodes rhizome, 10-120 parts of rhizoma alismatis, 30-120 parts of kudzuvine root, 10-60 parts of corn silk and 10-40 parts of stevia rebaudiana. The traditional Chinese medicine compound composition has good antihypertensive curative effect on patients with hypertension dizziness, can obviously improve clinical symptoms of dizziness, blurred vision, tinnitus, bitter taste, nausea and vomiting, limb numbness, vexation and insomnia of patients with hypertension dizziness, has definite curative effect on treating hypertension dizziness (wind phlegm disturbance syndrome), and is safe and reliable to use. CN116459315A discloses a traditional Chinese medicine composition for treating dizziness caused by cervical spondylosis and application thereof. The composition is prepared from the following raw materials in parts by weight: 10-20 parts of gastrodia elata, 10-20 parts of bubali, 10-30 parts of ligusticum wallichii, 10-20 parts of earthworm, 10-15 parts of musk, 20-30 parts of notopterygium root, 10-20 parts of polygala tenuifolia, 20-25 parts of borneol, 20-40 parts of rhizoma acori graminei and 10-15 parts of gardenia. The composition can be used as filling component of medicated pillow to make medicated pillow. The traditional Chinese medicine composition and the traditional Chinese medicine pillow prepared by the traditional Chinese medicine composition have good treatment effect on dizziness symptoms caused by cervical spondylosis, and have good application prospects. The composition aims at dizziness caused by diseases, does not occur from the treatment method of traditional Chinese medicine, and analyzes the cause caused by the dizziness, so that the composition has narrow adaptation range and is not beneficial to the treatment of the dizziness diseases.
Disclosure of Invention
The invention aims to provide a gastrodia elata compound composition for treating dizziness and a preparation method thereof. The invention aims at dizziness caused by liver yang hyperactivity due to turbid phlegm and internal accumulation according to the therapeutic rules of the traditional Chinese medicine, has obvious medicinal effect and good clinical curative effect.
In order to solve the technical problems, the invention is realized by adopting the following technical scheme: the gastrodia elata compound composition for treating dizziness is prepared from, by weight, 30-50 parts of gastrodia elata, 20-30 parts of ginseng, 15-25 parts of astragalus membranaceus, 18-22 parts of wolfberry fruit, 20-30 parts of Chinese yam, 15-25 parts of concha haliotidis, 20-30 parts of mulberry leaf, 15-25 parts of mother-of-pearl, 18-22 parts of dried orange peel, 20-30 parts of pinellia ternate, 10-20 parts of arisaema tuber, 15-25 parts of rhizoma atractylodis, 20-30 parts of motherwort herb, 18-22 parts of red paeony root, 20-30 parts of tree peony bark, 18-22 parts of ligusticum wallichii, 25-35 parts of hawthorn fruit, 20-30 parts of radish seed, 18-22 parts of immature bitter orange and 20-30 parts of perilla seed.
The gastrodia elata compound composition for treating dizziness is prepared from 40 parts of gastrodia elata, 25 parts of ginseng, 20 parts of astragalus membranaceus, 20 parts of medlar, 25 parts of Chinese yam, 20 parts of concha haliotidis, 25 parts of mulberry leaves, 20 parts of mother-of-pearl, 20 parts of dried orange peel, 25 parts of pinellia ternate, 15 parts of rhizoma arisaematis, 20 parts of rhizoma atractylodis, 25 parts of leonurus, 20 parts of radix paeoniae rubra, 25 parts of cortex moutan, 20 parts of ligusticum wallichii, 30 parts of hawthorn, 25 parts of radish seed, 20 parts of immature bitter orange and 25 parts of perilla seed.
The gastrodia elata compound composition for treating dizziness is prepared from, by weight, 30 parts of gastrodia elata, 20 parts of ginseng, 25 parts of astragalus membranaceus, 18 parts of medlar, 30 parts of Chinese yam, 25 parts of concha haliotidis, 20 parts of mulberry leaves, 25 parts of mother-of-pearl, 18 parts of dried orange peel, 30 parts of pinellia ternate, 10 parts of rhizoma arisaematis, 25 parts of rhizoma atractylodis, 20 parts of leonurus, 22 parts of radix paeoniae rubra, 20 parts of cortex moutan, 22 parts of ligusticum wallichii, 25 parts of hawthorn, 30 parts of radish seeds, 18 parts of immature bitter oranges and 30 parts of perilla seeds.
The gastrodia elata compound composition for treating dizziness is prepared from 50 parts of gastrodia elata, 30 parts of ginseng, 15 parts of astragalus membranaceus, 22 parts of medlar, 20 parts of Chinese yam, 15 parts of concha haliotidis, 30 parts of mulberry leaves, 15 parts of mother-of-pearl, 22 parts of dried orange peel, 20 parts of pinellia ternate, 20 parts of rhizoma arisaematis, 15 parts of rhizoma atractylodis, 30 parts of leonurus, 18 parts of red paeony root, 30 parts of cortex moutan, 18 parts of ligusticum wallichii, 35 parts of hawthorn, 20 parts of radish seeds, 22 parts of immature bitter orange and 30 parts of perilla.
The preparation method of the gastrodia elata compound composition for treating dizziness comprises the following steps:
(1) Decocting Concha Haliotidis and Concha Margaritifera with ten times of water for 1-3 hr, adding other Chinese medicinal materials, adding water ten times of all materials, decocting for 2 times and 2 hr each time, mixing decoctions, filtering, concentrating the filtrate to obtain extract with relative density of 1.10 at 80deg.C;
(2) Adding ethanol to make the ethanol content reach 50% -75%, continuously stirring, standing for 12-48 hr, filtering, recovering ethanol under reduced pressure to clean, concentrating to obtain extract with relative density of 1.05-1.10 at 50deg.C, drying, and pulverizing into dry extract powder to obtain dry extract powder;
(3) Pulverizing the dry extract powder, adding adjuvants, and making into pharmaceutical preparation.
The gastrodia elata compound composition for treating dizziness has the advantage that the dosage form of the pharmaceutical preparation is one of tablets, capsules and granules.
The application of the gastrodia elata compound composition for treating dizziness in preparing medicines for treating dizziness.
The application of the gastrodia elata compound composition for treating dizziness in preparing a medicine for treating dizziness belongs to liver-yang hyperactivity caused by turbid phlegm in the body.
Vertigo is recurrent and the course of the disease is longer, and usually the deficiency of the root causes is marked by the excess and excess, and usually the deficiency and excess are transformed. If the disease is in the early stage of onset, the disease is usually manifested as excessive syndrome, i.e. phlegm turbidity with middle energizer, blood stasis with internal resistance, or liver yang hyperactivity due to yin-yang imbalance, and if it is not healed for a long time, it can be transformed into deficiency syndrome of qi and blood deficiency and kidney essence deficiency; it is also manifested as dizziness due to deficiency of qi and blood and deficiency of kidney essence, repeated attacks, unsmooth qi-blood-body fluids running, and phlegm turbidity with blood stasis, which is accompanied by deficiency and excess. For the stagnation of turbid phlegm, the excessive upward movement of liver yang or the upward disturbance of turbid phlegm due to the stagnation of phlegm and transformation of fire can be translated into the excessive upward movement of liver yang; because of the accumulation of turbid phlegm, qi and blood are repressed, and phlegm and blood stasis can be caused in a long time. The most common is the hyperactivity of liver-yang due to turbid phlegm.
Based on the principle of treating both principal and secondary aspect of disease, the symptoms of hyperactivity of liver yang caused by turbid phlegm in the body are often caused in the elderly and weak patients, and the symptoms of deficiency of qi and blood and malnutrition of the brain are as follows: vertigo, sudden movement, fatigue, shortness of breath, pale complexion, tinnitus, headache, irritability, insomnia and dreaminess, slippery or wiry pulse, or soreness of the waist and knees, amnesia, dizziness, aversion to vomiting, headache such as tug, limb numbness and tremors, unfavorable language, and walking. Because of deficiency of qi and blood, listlessness and lazy speaking, pale complexion, deficiency of spleen and lung qi, shortness of breath, heart-mind malnutrition, palpitation and insomnia, qi and blood are firstly tonified, and spleen and stomach are healthy; in addition, liver yang hyperactivity is manifested as top-up, so dizziness, tinnitus, wiry pulse, need to calm liver, subdue yang, clear fire and stop wind; meanwhile, turbid phlegm obstructing the middle energizer and clearing orifices, so dizziness; phlegm is accumulation of dampness, heavy turbidity of dampness and repression of clear yang, so lassitude and heavy head are as good as one; turbid phlegm obstructing the middle energizer and causing adverse qi movement, chest distress; for yang deficiency failing to transform water, cold-retained fluid failing to flow upwards and over-center, palpitations due to heart down-flow, dry dampness and eliminate phlegm. At the same time, blood stasis blocks collaterals, qi and blood cannot flow normally, brain fails to nourish, so the medicine is used for treating dizziness, and is required to remove blood stasis, promote tissue regeneration, promote blood circulation and remove meridian obstruction. The stomach qi is reversed, so that phlegm and saliva are spitted; spleen yang is the repression of phlegm-dampness and not vibrating, so the symptoms of overeating and insomnia are all symptoms of phlegm-dampness accumulation, and spleen strengthening, transportation assisting, stomach qi dredging and descending are also needed.
The invention adopts ginseng, astragalus root, medlar and yam to invigorate qi and blood, strengthen spleen and stomach, tall gastrodia tuber, sea-ear shell, mulberry leaf and mother-of-pearl to calm liver and suppress yang, clear fire and stop wind, and are all monarch drugs; dried orange peel, pinellia tuber, arisaema tuber and rhizoma atractylodis are used as ministerial drugs for eliminating dampness and eliminating phlegm; herba Leonuri, radix Paeoniae Rubra, cortex moutan, and rhizoma Ligustici Chuanxiong with effects of removing blood stasis, promoting tissue regeneration, promoting blood circulation, and dredging collaterals as adjuvant drugs; fructus crataegi, raphani semen, fructus Aurantii Immaturus, su Zijian and spleen assist transportation, and remove gastric qi, and the whole formula contains Ginseng radix, radix astragali, fructus Lycii, rhizoma Dioscoreae, rhizoma Gastrodiae, concha Haliotidis, folium Mori, concha Margaritifera, pericarpium Citri Tangerinae, rhizoma Pinelliae, rhizoma arisaematis, rhizoma Atractylodis, herba Leonuri, radix Paeoniae Rubra, cortex moutan, rhizoma Ligustici Chuanxiong, fructus crataegi, raphani semen, fructus Aurantii Immaturus, and fructus Perillae, and can be used for treating giddiness due to liver yang hyperactivity caused by turbid phlegm by invigorating qi and blood, nourishing spleen and stomach, suppressing hyperactive liver yang, clearing pathogenic fire and expelling pathogenic wind, eliminating dampness and phlegm, removing blood stasis and promoting tissue regeneration, promoting blood circulation and removing obstruction in collaterals, invigorating spleen and promoting transportation, and removing gastric qi.
Detailed Description
The application is further described below in conjunction with the detailed description. It is to be understood that these examples are illustrative of the present application and are not intended to limit the scope of the present application. Further, it is understood that various changes and modifications of the present application may be made by those skilled in the art after reading the description of the present application, and that such equivalents are intended to fall within the scope of the application as defined in the appended claims.
Example 1: 40g of gastrodia tuber, 25g of ginseng, 20g of astragalus root, 20g of medlar, 25g of Chinese yam, 20g of concha haliotidis, 25g of mulberry leaf, 20g of mother-of-pearl, 20g of dried orange peel, 25g of pinellia tuber, 15g of arisaema tuber, 20g of rhizoma atractylodis, 25g of motherwort herb, 20g of red paeony root, 25g of tree peony bark, 20g of szechuan lovage rhizome, 30g of hawthorn fruit, 25g of radish seed, 20g of immature bitter orange and 25g of perilla seed, and the preparation method comprises the following steps:
(1) Decocting Concha Haliotidis and Concha Margaritifera with ten times of water for 2 hr, adding other Chinese medicinal materials, adding water ten times of all materials, decocting for 2 times and 2 hr each time, mixing decoctions, filtering, concentrating the filtrate to obtain extract with relative density of 1.10 at 80deg.C;
(2) Adding ethanol to reach ethanol content of 65%, stirring, standing for 36 hr, filtering, recovering ethanol from filtrate under reduced pressure to clean and concentrating to obtain extract with relative density of 1.08 at 50deg.C, drying, and pulverizing into dry extract powder to obtain dry extract powder;
(3) Pulverizing the dry extract powder, adding dextrin, and making into granule.
Example 2: 40g of gastrodia tuber, 25g of ginseng, 20g of astragalus root, 20g of medlar, 25g of Chinese yam, 20g of concha haliotidis, 25g of mulberry leaf, 20g of mother-of-pearl, 20g of dried orange peel, 25g of pinellia tuber, 15g of arisaema tuber, 20g of rhizoma atractylodis, 25g of motherwort herb, 20g of red paeony root, 25g of tree peony bark, 20g of szechuan lovage rhizome, 30g of hawthorn fruit, 25g of radish seed, 20g of immature bitter orange and 25g of perilla seed, and the preparation method comprises the following steps:
(1) Decocting Concha Haliotidis and Concha Margaritifera with ten times of water for 1 hr, adding other Chinese medicinal materials, adding water ten times of all materials, decocting for 2 times and 2 hr each time, mixing decoctions, filtering, concentrating the filtrate to obtain extract with relative density of 1.10 at 80deg.C;
(2) Adding ethanol to make ethanol content reach 75%, continuously stirring, standing for 12 hr, filtering, recovering ethanol from filtrate under reduced pressure to clean and concentrating to extract with relative density of 1.10 at 50deg.C, drying the extract, and pulverizing into dry extract powder to obtain dry extract powder;
(3) Pulverizing the dry extract powder, adding starch, and making into tablet.
Example 3: 40g of gastrodia tuber, 25g of ginseng, 20g of astragalus root, 20g of medlar, 25g of Chinese yam, 20g of concha haliotidis, 25g of mulberry leaf, 20g of mother-of-pearl, 20g of dried orange peel, 25g of pinellia tuber, 15g of arisaema tuber, 20g of rhizoma atractylodis, 25g of motherwort herb, 20g of red paeony root, 25g of tree peony bark, 20g of szechuan lovage rhizome, 30g of hawthorn fruit, 25g of radish seed, 20g of immature bitter orange and 25g of perilla seed, and the preparation method comprises the following steps:
(1) Decocting Concha Haliotidis and Concha Margaritifera with ten times of water for 3 hr, adding other Chinese medicinal materials, adding water ten times of all materials, decocting for 2 times and 2 hr each time, mixing decoctions, filtering, concentrating the filtrate to obtain extract with relative density of 1.10 at 80deg.C;
(2) Adding ethanol to make the ethanol content reach 50%, continuously stirring, standing for 48 hr, filtering, recovering ethanol from filtrate under reduced pressure to clean and concentrating to extract with relative density of 1.05 at 50deg.C, drying the extract, and pulverizing into dry extract powder to obtain dry extract powder;
(3) Pulverizing the dry extract powder, adding microcrystalline cellulose, and making into capsule.
Example 4: the invention tests the dizziness caused by the guinea pig chloroform
Taking qualified guinea pigs, wherein the male and female parts are half, the quality of the guinea pigs is 250-300 g, the guinea pigs are randomly divided into 5 groups, namely a control group, the groups (10 g/kg) of the embodiment 1-3 of the invention, the groups (12.5 mg/kg) of the difenidol hydrochloride serving as a positive drug, 10 animals in each group, and the corresponding drugs are given to each group, wherein the administration volume is 10mL/kg, 1 time a day and 14 times a total administration. The last administration was carried out for 30min, 15. Mu.L of chloroform was dropped from the right ear of guinea pig, and the latency and duration of appearance of nystagmus were observed, the duration being bounded by 60min, and the results are shown in Table 1.
TABLE 1 Effect of the invention on chloroform-induced guinea pig nystagmus latency and duration of tremor (x+ -s, n=10)
Comparison to the control group: *P<0.05,** P is less than 0.01
As can be seen from Table 1, the groups of examples 1-3 of the present invention significantly prolonged guinea pig nystagmus latency and shortened nystagmus duration, and the differences were significant (P < 0.05, 0.01) compared with the control group, and the effects were similar to those of the positive drugs.
Example 5: the invention relates to a clinical curative effect evaluation for treating dizziness caused by liver yang hyperactivity due to turbid phlegm and internal accumulation
1. Case origin: 120 cases of dizziness caused by liver yang hyperactivity due to phlegm accumulation in the patients who visit the patients in 2022, 1 month and 2023, 1 month are selected.
2. Diagnostic criteria: ① Dizziness is a visual disturbance or a sense of rotation of the user, and is often induced by head or body position changes. ② Dizziness, dizziness with other symptoms of transient ischemia such as brainstem, etc., such as eye symptoms, inner ear pain, numbness of limbs, weakness, cataplexy, syncope, etc. ③ The brain stem injury sign such as cornea or pharyngeal reflex decline or disappearance, regulation and auxiliary disorder, spontaneous or inflammation induced after cervical compression of one side vertebral artery, positive pathological reflex and the like ④ are used for measuring blood pressure, blood checking hemoglobin, erythrocyte count and electrocardiogram, electric measurement and hearing, brain stem evoked potential, cervical vertebra x-ray shooting, transcranial Doppler ultrasound and the like, which are helpful for definite diagnosis and conditional ct examination. ⑤ Except for dizziness patients caused by tumor, swelling trauma, brain trauma, blood, cerebral infarction, cerebral hemorrhage, etc.
3. Case selection: (1) meets the diagnosis standard of Western vertigo; (2) Meets the diagnosis standard of dizziness caused by liver yang hyperactivity due to phlegm turbidity in traditional Chinese medicine; the method comprises the following steps: the clinical symptoms are as follows: vertigo, sudden movement, fatigue, shortness of breath, pale complexion, tinnitus, headache, irritability, insomnia and dreaminess, slippery or wiry pulse, or soreness of the waist and knees, amnesia, dizziness, aversion to vomiting, headache such as tug, limb numbness and tremors, unfavorable language, and walking.
4. Efficacy assessment criteria: and (3) healing: the symptoms such as dizziness disappear, and the curative effect index is more than or equal to 90%. The effect is shown: the symptoms such as dizziness and the like are obviously reduced, the head is slightly faint or the dizziness is slight but not accompanied with rotation and shaking sense of the head and the scenery, and the head can normally live and work. The curative effect index is more than or equal to 70 percent and is less than 90 percent. The method is effective: dizziness or dizziness is relieved, only slight rotation or shaking feeling of scenery is accompanied, and life and work are affected although work can be adhered to. The curative effect index is more than or equal to 30 percent and is less than 70 percent. Invalidation: symptoms such as dizziness, dizziness and the like are not improved or aggravated, and the curative effect index is less than 30 percent.
5. The treatment process comprises the following steps: the granule product prepared in the embodiment 1 of the invention (the daily prescription dose is 40g of tall gastrodia tuber, 25g of ginseng, 20g of astragalus root, 20g of medlar, 25g of Chinese yam, 20g of sea-ear shell, 25g of mulberry leaf, 20g of mother-of-pearl, 20g of dried orange peel, 25g of pinellia tuber, 15g of arisaema tuber, 20g of rhizoma atractylodis, 25g of motherwort, 20g of red paeony root, 25g of tree peony bark, 20g of szechuan lovage rhizome, 30g of hawthorn fruit, 25g of radish seed, 20g of immature bitter orange and 25g of perilla seed) is taken for 1 month in 2 bags each time 3 times per day; the control group takes Jiuzhitang Gastrodia elata Uncaria granule (without sucrose) approval document number is national medicine standard character Z51021084, and the production enterprise is Jiuzhitang Jinding medical industry Co., ltd, one bag (10 g) at a time, 3 times a day, and 1 month.
6. The treatment results are shown in Table 2.
Table 2 comparison of two clinical efficacy
Group of Healing of the wound Has obvious effect Effective and effective Invalidation of Total effective rate (%)
Control group 15 14 14 17 71.7
Example 1 group 28 13 15 4 93.3
7. Conclusion: the clinical efficacy of the two groups is compared, the clinical effective rate of the example 1 group after treatment is 93.3 percent and is obviously higher than that of the control group by 71.7 percent, which proves that the invention has better clinical treatment effect on dizziness caused by liver yang hyperactivity due to turbid phlegm.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (7)

1. A gastrodia elata compound composition for treating dizziness is characterized in that: the gastrodia elata compound composition is prepared from, by weight, 30-50 parts of gastrodia elata, 20-30 parts of ginseng, 15-25 parts of astragalus membranaceus, 18-22 parts of wolfberry fruit, 20-30 parts of Chinese yam, 15-25 parts of concha haliotidis, 20-30 parts of mulberry leaf, 15-25 parts of mother-of-pearl, 18-22 parts of dried orange peel, 20-30 parts of pinellia ternate, 10-20 parts of rhizoma arisaematis, 15-25 parts of rhizoma atractylodis, 20-30 parts of leonurus, 18-22 parts of red paeony root, 20-30 parts of tree peony bark, 18-22 parts of ligusticum wallichii, 25-35 parts of hawthorn fruit, 20-30 parts of radish seed, 18-22 parts of immature bitter orange and 20-30 parts of perilla fruit.
2. The gastrodia elata compound composition for treating dizziness according to claim 1, wherein: the gastrodia elata compound composition is prepared from 40 parts of gastrodia elata, 25 parts of ginseng, 20 parts of astragalus membranaceus, 20 parts of medlar, 25 parts of Chinese yam, 20 parts of concha haliotidis, 25 parts of mulberry leaves, 20 parts of mother-of-pearl, 20 parts of dried orange peel, 25 parts of pinellia ternate, 15 parts of rhizoma arisaematis, 20 parts of rhizoma atractylodis, 25 parts of leonurus, 20 parts of red paeony root, 25 parts of tree peony bark, 20 parts of ligusticum wallichii, 30 parts of hawthorn, 25 parts of radish seed, 20 parts of immature bitter orange and 25 parts of perilla seed.
3. The gastrodia elata compound composition for treating dizziness according to claim 1, wherein: the gastrodia elata compound composition is prepared from, by weight, 30 parts of gastrodia elata, 20 parts of ginseng, 25 parts of astragalus mongholicus, 18 parts of medlar, 30 parts of Chinese yam, 25 parts of concha haliotidis, 20 parts of mulberry leaf, 25 parts of mother-of-pearl, 18 parts of dried orange peel, 30 parts of pinellia ternate, 10 parts of rhizoma arisaematis, 25 parts of rhizoma atractylodis, 20 parts of leonurus, 22 parts of red paeony root, 20 parts of tree peony bark, 22 parts of ligusticum wallichii, 25 parts of hawthorn, 30 parts of radish seed, 18 parts of immature bitter orange and 30 parts of perilla seed.
4. The gastrodia elata compound composition for treating dizziness according to claim 1, wherein: the preparation method comprises the following steps:
(1) Decocting Concha Haliotidis and Concha Margaritifera with ten times of water for 1-3 hr, adding other Chinese medicinal materials, adding water ten times of all materials, decocting for 2 times and 2 hr each time, mixing decoctions, filtering, concentrating the filtrate to obtain extract with relative density of 1.10 at 80deg.C;
(2) Adding ethanol to make the ethanol content reach 50% -75%, continuously stirring, standing for 12-48 hr, filtering, recovering ethanol under reduced pressure to clean, concentrating to obtain extract with relative density of 1.05-1.10 at 50deg.C, drying, and pulverizing into dry extract powder to obtain dry extract powder;
(3) Pulverizing the dry extract powder, adding adjuvants, and making into pharmaceutical preparation.
5. The gastrodia elata compound composition for treating dizziness according to claim 4, wherein: the dosage form of the pharmaceutical preparation is one of tablets, capsules and granules.
6. The use of the gastrodia elata compound composition for treating dizziness according to claim 1 in preparing a medicament for treating dizziness.
7. The application of the gastrodia elata compound composition for treating dizziness according to claim 1 in preparing a medicament for treating dizziness, which is characterized in that: the pattern of dizziness belongs to the pattern of hyperactivity of liver yang caused by turbid phlegm in the interior.
CN202410634638.4A 2024-05-22 2024-05-22 Gastrodia elata compound composition for treating dizziness and preparation method thereof Pending CN118477145A (en)

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