CN118286330A

CN118286330A - Traditional Chinese medicine composition for treating pruritus vulvae and preparation method thereof

Info

Publication number: CN118286330A
Application number: CN202410509156.6A
Authority: CN
Inventors: 邓丹萍; 朱承慧; 刘向儒; 何平; 彭小飞; 廖标武; 孙智玲; 陈艳丽
Original assignee: Chenzhou Hospital Of Traditional Chinese Medicine
Current assignee: Chenzhou Hospital Of Traditional Chinese Medicine
Priority date: 2024-04-26
Filing date: 2024-04-26
Publication date: 2024-07-05

Abstract

The invention discloses a traditional Chinese medicine composition for treating colpitis and a preparation method thereof, wherein the traditional Chinese medicine composition mainly comprises 12 Chinese herbal medicines of radix sophorae flavescentis, cortex phellodendri, cortex dictamni, polygonum cuspidatum, dandelion, wild chrysanthemum, purslane, fructus cnidii, radix angelicae, verbena, peppermint and radix sileris, and also comprises salix chinensis, eucalyptus leaves, ephedra, anthocyanin quaternary ammonium salt, basil leaves, cordate houttuynia, polysialic acid, polydopamine, antibacterial polypeptide modified chitosan hydrochloride and artesunate hydrochloride, and various medicaments are prepared by mixing traditional Chinese medicines with antibacterial and bacteriostatic biocompatible materials. Can be used for treating pudendum itch and leukorrhagia due to yin fluid accumulation and burn caused by insect toxin, with symptoms of pudendum itch, leukorrhagia, and yellow and thick color; bacterial, fungal, trichomonas vaginitis, vulvitis. In clinical trials, the traditional Chinese medicine composition has remarkable treatment effect, and the cure rate reaches more than 95%.

Description

Traditional Chinese medicine composition for treating pruritus vulvae and preparation method thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition taking Chinese herbal medicines as raw materials and having the effect of treating pruritus vulvae and a preparation method thereof.

Background

Pudendum itch is a common disease of gynaecology, and can occur in various age groups, and refers to female pudendum itch, even itching and pain, restlessness, or increased leucorrhea, and the like, which is called as 'pudendum itch', also called as 'vulval pruritus'. Jin Daige Hongcheng (urgent prescription for elbow preparation) is described as follows: the pudendum itch is called as pudendum itch for the first time, the pudendum itch symptoms are specified, and the method for treating the pudendum itch is additionally provided. The following medical science inherits that the following medical science indicates that the "pruritus vulvae" is carried in the "Zhuan Yuan Zhi Lun" by Sui Dynasty Yuan Fang (the "disease source and condition of diseases"), and indicates that the disease is caused by the insect diet. Song Daichen from the 'Fu ren Daquan Liang Fang' is a special list of 'woman itching of the vagina' on the basis of the former, and the itching of the vagina is used as the independent gynecological disease. The pruritus vulvae symptoms of western medicine such as pruritus vulvae, vulvitis, colpitis, and hypopigmentation of vulva are related to the disease. The cause of pruritus vulvae is complex, and the disease can be caused by contact, allergy, chemical irritation, systemic chronic diseases and the like. The pruritus vulvae has a serious influence on the health of the female heart, and can cause a series of complications besides local discomfort, harm to the health of the female, and more importantly, anxiety of the patient. The occurrence of pruritus vulvae is considered to be related to the dysfunction of liver, kidney and spleen by traditional Chinese medicine. The liver meridian circulates around the yin device to store blood, which is the viscera of Fenghu; spleen governs transportation and transformation of water dampness; the Xue Ji is summarized in that the pruritus vulvae of women belongs to the liver meridian, and has symptoms of liver and spleen depression, liver and spleen qi deficiency, damp-heat downward flow, and is treated by addition and subtraction of radix gentianae liver-purging decoction, xiaoyao san, spleen-returning decoction, xiao chai Hu decoction, and the like, and is externally used with peach seed paste, realgar, and the like for disinsection. Kidneys store essence to govern reproduction and induce resuscitation in both yin. The theory of disease sources and the theory of women's miscellaneous diseases are: the kidney is nourished in the yin apparatus, kidney qi deficiency … … is the condition that pathogenic wind is carried over, pathogenic wind is carried over the striae and striae, healthy qi is not leaked, pathogenic qi is coherent, and skin itch exists. "modern medicine believes that irritating vaginal discharge is an important cause of pruritus vulvae.

At present, the treatment of pruritus vulvae mainly comprises antibiosis and antiphlogosis, and aims to improve the micro-ecological environment of the vagina in a patient, if the antibiosis and antiphlogosis medicines are used for a long time, the medicines are easy to generate drug dependence and have high incidence of adverse reactions. The symptoms and signs of the pruritus vulvae disease are complicated in most cases, especially deficiency of liver-yin and kidney-yin, downward flow of damp-heat and breeding of damp worms, and the treatment effect on single pathogenesis is limited. Therefore, finding a therapeutic method or drug with good therapeutic effect and low toxic and side effects has become an important research point in the field. The traditional Chinese medicine has obvious advantages through oral administration or external treatment. The traditional Chinese medicine and the compound preparation thereof have the characteristics of multiple ways and multiple targets, and according to the dialectical treatment method of the traditional Chinese medicine, the invention is based on the principle of combining the traditional Chinese medicine treatment of pruritus vulvae with dialectical treatment, and the invention starts from the whole body, follows the principle of 'treating the external and the internal of the essential points', combines the whole body with the local part to treat, thereby achieving the purpose of treating the root cause.

Disclosure of Invention

The invention aims to solve the technical problems and overcome the defects, and provides a traditional Chinese medicine composition for treating pruritus vulvae, which has the advantages of obvious curative effect, low cost and less side effect, and a preparation method thereof.

The technical problems to be solved by the invention are realized by the following technical scheme:

Through continuous practice, a core prescription for treating pruritus vulvae is gradually developed, and the core prescription comprises 12 Chinese herbal medicines of radix sophorae flavescentis, cortex phellodendri, cortex dictamni, polygonum cuspidatum, dandelion, wild chrysanthemum, purslane, fructus cnidii, radix angelicae, verbena, mint and radix sileris.

The invention relates to a core prescription of a traditional Chinese medicine composition for treating pruritus vulvae, which comprises 20-30 parts of radix sophorae flavescentis, 20-30 parts of cortex phellodendri, 20-30 parts of cortex dictamni, 20-30 parts of polygonum cuspidatum, 20-30 parts of dandelion, 20-30 parts of flos chrysanthemi indici, 20-30 parts of purslane, 20-30 parts of fructus cnidii, 30-40 parts of radix angelicae, 20-30 parts of verbena, 10-20 parts of mint and 6-15 parts of radix sileris.

The core prescription of the traditional Chinese medicine composition for treating pruritus vulvae comprises 24 parts of radix sophorae flavescentis, 24 parts of cortex phellodendri, 24 parts of cortex dictamni, 24 parts of polygonum cuspidatum, 24 parts of dandelion, 24 parts of wild chrysanthemum flower, 24 parts of purslane, 24 parts of fructus cnidii, 32 parts of radix angelicae, 24 parts of verbena, 16 parts of mint and 8 parts of radix sileris.

The traditional Chinese medicine composition for treating pudendum itch also comprises 3-8 parts of salix mongolica, 2-5 parts of eucalyptus leaves, 2-6 parts of ephedra, 1-4 parts of anthocyanin quaternary ammonium salt, 2-4 parts of basil leaves, 2-7 parts of cordate houttuynia, 5-18 parts of polysialic acid, 10-30 parts of polydopamine, 2-5 parts of antibacterial polypeptide modified chitosan hydrochloride and 1-1.5 parts of artesunate hydrochloride.

The preparation method of the traditional Chinese medicine composition for treating pruritus vulvae comprises the following steps:

(1) Weighing radix Sophorae Flavescentis, cortex Phellodendri, cortex Dictamni Radicis, rhizoma Polygoni Cuspidati, herba Taraxaci, flos Chrysanthemi Indici, herba Portulacae, fructus Cnidii, radix Angelicae Dahuricae, herba Verbenae, herba Menthae, and radix Saposhnikoviae, soaking in 5-10 times of water for 0.5-1.5 hr, decocting for 0.5-3.0 hr, and decocting for 0.5-2.0 hr to obtain decoction A;

(2) Weighing cyclocarya paliurus, eucalyptus leaf, ephedra herb, basil leaf and houttuynia cordata according to the formula proportion, soaking in 3-7 times of water for 0.5-1.5 hours, decocting for two times, wherein the first time is 0.5-1.5 hours, the second time is 2-4 times of water, decocting for 0.5-1.0 hour, cooling to room temperature, adding anthocyanin quaternary ammonium salt, polysialic acid and polydopamine, and stirring uniformly to obtain decoction B;

(3) Mixing the decoction A and the decoction B, filtering to obtain filtrate, leaching the filter residue with 1-2 times of water, filtering, mixing the filtrate with the washing liquid, and concentrating the mixed solution at low temperature under reduced pressure to 1/5-1/2 of the volume of the original filtrate;

(4) Adding sodium benzoate 0.3-0.8% by weight into the concentrated solution, stirring, mixing with antibacterial polypeptide modified chitosan hydrochloride and artesunate hydrochloride, adding into the concentrated solution, stirring again, filtering, and bottling the filtrate.

It is still another object of the present invention to provide a preparation containing the Chinese medicinal composition of the present invention, which is an external preparation-lotion.

The invention also aims at containing the application of the traditional Chinese medicine composition in preparing the medicine for treating pruritus vulvae.

The invention also aims at containing the application of the traditional Chinese medicine composition in preparing medicines for treating colpitis.

The traditional Chinese medicine composition for treating pruritus vulvae is mainly used for treating pruritus vulvae caused by internal accumulation of insect poison and yin fluid burn.

Pharmacological action and efficacy of traditional Chinese medicine in the raw materials:

Kuh-seng, bitter and cold. It enters heart, liver, stomach, large intestine and bladder meridians. Has the functions of clearing heat, eliminating dampness, killing parasites and promoting urination. Modern pharmacological research shows that the product has the functions of resisting pathogenic microbe, relieving fever, resisting inflammation, resisting allergic reaction, resisting tumor, resisting arrhythmia, etc.

Cortex Phellodendri, which is a medicinal material in Hunan province, bitter and cold. Enter kidney and bladder meridians. Has the functions of clearing heat and drying dampness, purging fire and removing steam, and detoxicating and treating sore. Modern pharmacological researches have shown that the product has the effects of resisting pathogenic microorganisms, resisting inflammation, inhibiting immunity, reducing blood pressure, resisting oxidation, resisting gout, improving energy metabolism and the like.

Cortex Dictamni Radicis, bitter and cold. Enter spleen, stomach and bladder meridians. Has the functions of clearing heat and eliminating dampness, dispelling wind and detoxicating. Modern pharmacological research shows that the product has the functions of resisting pathogenic microorganisms, resisting endotoxin, resisting inflammation, inhibiting immunity, protecting liver and the like.

Giant knotweed rhizome: slightly bitter and slightly cold. It enters liver, gallbladder and lung meridians. Has the functions of promoting diuresis, eliminating jaundice, clearing away heat and toxic material, eliminating blood stasis, relieving pain, relieving cough and eliminating phlegm. Modern pharmacological researches have shown that the product has wide pharmacological actions, including stabilizing blood pressure and shock, resisting myocardial ischemia and atherosclerosis, resisting thrombus, improving cerebral ischemia and protecting brain injury, resisting lung injury and fibrosis, reducing blood fat, benefiting gall bladder, protecting liver, resisting inflammation, resisting oxidation, resisting bacteria, resisting viruses, resisting tumor and the like.

Dandelion is bitter, sweet and cold. Enter liver and stomach meridians. Has the functions of clearing away heat and toxic material, detumescence, resolving hard mass, promoting urination and treating stranguria. Modern pharmacological research shows that the product has the functions of resisting pathogenic microorganisms, resisting inflammation, resisting ulcer and the like.

Wild chrysanthemum flower, bitter and pungent, and slightly cold. Enter liver and heart meridians. Has the functions of clearing away heat and toxic material, purging pathogenic fire and calming liver. Modern pharmacological research shows that the product has the functions of resisting pathogenic microorganisms, resisting inflammation, protecting liver and the like.

Purslane, sour and cold. Enter liver and large intestine meridians. Has effects in clearing away heat and toxic materials, cooling blood, stopping bleeding, and relieving dysentery. Modern pharmacological research shows that the product has the functions of resisting pathogenic microorganisms, resisting inflammation, reducing blood sugar, reducing blood fat and the like.

Fructus Cnidii, pungent and bitter, and warm; it is slightly toxic. Enter kidney meridian. Has the functions of eliminating dampness, dispelling wind, killing parasites, relieving itching, warming kidney and strengthening yang. Modern pharmacological research shows that the product has the functions of resisting pathogenic microorganisms, relieving itching, resisting allergic reaction, resisting inflammation, easing pain, resisting tumor and the like.

Xiang Bai Zhi is a Hunan province and a way of herb, pungent and warm. Enter stomach, large intestine and lung meridian. Has the functions of relieving exterior syndrome, dispelling cold, dispelling wind, relieving pain, freeing nasal orifices, eliminating dampness, stopping leukorrhagia, and relieving swelling and pus. Modern pharmacological researches have shown that the product has the effects of relieving fever, easing pain, resisting inflammation, inhibiting pathogenic microorganisms, resisting oxidation, resisting tumor and the like.

Herba Verbenae, bitter and cool. Enter liver and spleen meridians. Has the functions of promoting blood circulation, removing blood stasis, removing toxic substance, promoting diuresis, eliminating jaundice and checking malaria. Modern pharmacological researches have shown that this product has the effects of resisting early pregnancy, resisting tumor, resisting inflammation and relieving pain.

Peppermint, herba Menthae, pungent and cool. It enters lung and liver meridians. Has the functions of dispelling wind and heat, clearing head and eyes, relieving sore throat, promoting eruption, soothing liver and promoting qi circulation. Modern pharmacological researches have shown that it has the effects of inducing sweat, relieving fever, relieving pain, tranquilizing, resisting pathogen, relieving spasm, promoting bile flow and removing calculus.

Fang Feng, xin, gan and Weak temperature. It enters the urinary bladder, liver and spleen meridians. Has the functions of dispelling wind, relieving exterior syndrome, eliminating dampness, relieving pain and relieving spasm. Modern pharmacological researches have shown that the product has the effects of relieving fever, easing pain, resisting inflammation, resisting allergy, resisting tumor, resisting oxidation, regulating immunity, resisting coagulation and the like.

Cyclocarya paliurus, bitter and cold. The Chinese medicinal composition has the effects of clearing heat from liver, gall bladder and bladder channel, promoting urination and detoxifying. Modern pharmacological researches have proved that the product has the effects of treating acute and chronic hepatitis, cholecystitis, cholelithiasis, vesical calculus, gonorrhea, syphilis, hemorrhoid, traumatic injury, scald, etc.

Eucalyptus leaves, pungent taste; bitter; it is cold in nature. It enters lung, stomach, spleen and liver meridians. Modern pharmacological researches have proved that the product has the effects of dispelling wind, relieving exterior syndrome, clearing away heat and toxic materials, resolving phlegm, regulating qi-flowing, killing parasites and relieving itching. Is used for treating common cold, dyspnea and cough due to high fever, pertussis, abdominal distention and pain, diarrhea, dysentery, hook, filariasis, malaria, rheumatalgia, eczema, scabies, burn and scald, and traumatic hemorrhage.

Ma Huang is pungent and slightly bitter and warm. Enter lung meridian and bladder meridian. Modern pharmacological studies have indicated that it has the actions of inducing sweat, relieving dyspnea and inducing diuresis. Is mainly used for treating exterior excess caused by typhoid fever, aversion to cold, no sweat, headache, nasal obstruction and bone joint pain; cough and asthma; edema with wind and water, and difficult urination; wind evil is a persistent arthralgia, skin is not benevolent, and rubella is itchy.

Basil leaves are pungent, sweet and warm in nature. Enter lung, spleen, stomach and large intestine meridians. Modern pharmacological researches have proved that the product has the effects of dispelling wind, relieving exterior syndrome, eliminating dampness, regulating stomach, promoting qi and blood circulation, removing toxic substances and relieving swelling. It is commonly used for treating common cold, headache, fever, cough, heatstroke, indigestion, anorexia, abdominal distention, pain, emesis, dysentery, rheumatalgia, spermatorrhea, menoxenia, toothache, halitosis, pterygium, skin sore, urticaria, pruritus, traumatic injury, snake and insect bite.

Houttuynia cordata, pungent; cold. It enters liver meridian and lung meridian. Modern pharmacological studies show that this herb has the actions of clearing heat and removing toxicity, inducing diuresis and relieving swelling, etc. Can be used for treating pneumonia, lung abscess, dysentery, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, rectocele, eczema, tinea, and scabies.

Anthocyanin quaternary ammonium salt, anthocyanin is a powerful antioxidant which can protect the human body from damage by a harmful substance called free radical. The anthocyanin quaternary ammonium salt can also enhance vascular elasticity, improve circulatory system and smoothness of skin, inhibit inflammation and allergy, improve flexibility of joints, delay aging, protect joints, inhibit inflammation, prevent allergy and the like, and has remarkable antibacterial and bacteriostatic effects through quaternary ammonium salt derivatization.

Polysialic acid is a protein drug modified material with potential higher than polyethylene glycol, has better biocompatibility, biodegradability and high hydrophilicity, has the function of resisting human immune system identification, and has the effects of preventing pathogen invasion, promoting digestion, promoting nervous system development, promoting wound healing and the like.

Polydopamine is a high-stability substance obtained by polymerizing dopamine, and has multiple characteristics such as oxidation resistance, photothermal conversion, adhesiveness, biocompatibility, biodegradation and the like.

The antibacterial polypeptide modified chitosan hydrochloride has the substrate of natural polysaccharide chitin, is partially acetyl chitosan removed, has various physiological functions of biodegradability, biocompatibility, no toxicity, bacteriostasis, anticancer, lipid reduction, immunity enhancement and the like, and has obviously improved antibacterial effect after being modified by the antibacterial polypeptide and obviously improved water solubility after hydrochlorination.

Artesunate hydrochloride, wherein the antibacterial matrix is artemisinin, and in order to improve the water solubility of artemisinin, scientists replace the hydroxyl group on the 10-carbon of dihydroartemisinin with an ester group to obtain artemisinin ester derivatives. Among these ester derivatives, sodium salt of artesunate is the earliest water-soluble arteannuin derivative, and artesunate hydrochloride has various pharmacological effects such as anti-tumor, pulmonary hypertension treatment, diabetes resistance, embryotoxicity, antifungal, immunoregulation, antiviral, anti-inflammatory, anti-pulmonary fibrosis, antibacterial, cardiovascular effect and the like.

The pudendum itch is from volume five of the Ji Fang Ji Bei Zhu. Also known as vulval itching, vulvar itching. The disease refers to pruritus vulvae and pruritus vulvae of children and women, even the pruritus can affect anus, and pruritus pain and pain around anus, happiness and scratching, and severe people sit restlessness, and seriously affect normal life of individuals. The etiology of the disease is mainly the dysfunction of liver, kidney and spleen. The liver meridian bypasses the yin device during circulation, and the liver is a blood-storing organ and is easy to be invaded by pathogenic qi of wind, fire, damp and heat; the physiological function of the kidney is Tibetan essence; spleen is the viscera that transform water into dampness. The liver meridian is invaded by pathogenic qi of damp-heat or liver depression and spleen deficiency lead to internal pathogenic fire and dampness generation, and the pathogenic damp-heat has heavy nature and tends to be downward, so that the pathogenic qi is accumulated in the vulva along with downward flow of the meridian; Or infects insect disease, the insect disturbs pudendum, and the pudendum itch. In addition, the liver and kidney are deficient in essence and blood, and the primordial qi is deficient, so that the liver and kidney are easily weathered, however, the theory of traditional Chinese medicine states that the body is ill, the pain is not good, the essence and blood are deficient, and the pudendum skin is not good and itchy. Clinically, the disease is common in two factors of damp-heat in the liver and spleen and yin deficiency in the liver and kidney. The main mechanism can be discussed in terms of both the virtual and real aspects. Deficiency of essence and blood of liver and kidney, deficiency of primordial qi, easy wind generation and itching due to skin deficiency of pudendum, which belongs to deficiency syndrome; pathogenic fire and dampness are generated in the body due to invasion of liver meridian by pathogenic qi of damp-heat or liver depression and spleen deficiency, and pathogenic qi is accumulated in the vulva along with downward flow of damp-heat; the pudendum infection with damp worms is pudendum itching, which is an excess syndrome. The pathogenesis is mainly caused by the accumulation of damp-heat toxin in yin family, and the occurrence of the disease can be caused by unclean life; damp-heat toxin is accumulated in liver meridian and stagnates in yin to cause unsmooth local qi and blood circulation, qi and blood circulation is blocked, heat is removed for a long time to generate fire, and heat evil burns yin essence, so that sores and ulcers are easy to occur at the pudendum, and meat rot is caused by heat predominance and is suppurative for a long time. Therefore, the local redness and swelling, heat sensation and pain sensation, and even ulceration and purulence can be seen. If pathogenic qi of damp-heat is accumulated in the private parts of the family for a long time, the private parts are generally in the region of low dampness, which is easy to infect the pathogenic insects, and the damp-insects invade the private parts and can cause ulceration. Cold congeals phlegm and is stasis, even if the body is yang-deficiency or liver-kidney-deficiency is elucidated, in both cases, pathogenic qi of cold-dampness can take charge of yin, and "people with weak body feel and more accompanying people". If the body is deficient in healthy qi or the disease is lingering due to the deficiency of healthy qi, the damp toxin cannot be removed from the body, the tumor will be further broken, even the abscess will be dribbling, the disease will not be healed for a long time, or the ulcer in the yin will not be healed for a long time. Vulva is not clean, or is a place where yin is wet for a long time, so that damp worms can grow, and worms erode yin to cause pruritus vulvae. In the recipe, kuh-seng and phellodendron bark are bitter and cold, wherein the phellodendron bark selects genuine medicinal materials in Hunan province, is good at clearing down-jiao damp-heat and purging kidney deficiency fire, and is used as a monarch drug for clearing heat and drying dampness, killing parasites and relieving itching. Cortex Dictamni Radicis is bitter and cold, has effects of clearing heat and eliminating dampness, dispelling pathogenic wind and relieving itching, and has enhanced effect of eliminating dampness and relieving itching when combined with the monarch drug radix Sophorae Flavescentis; the giant knotweed rhizome is bitter and cold, purges damp-heat and passes through a water channel, and is a good medicine for clearing damp-heat; dandelion and wild chrysanthemum are bitter and cold, and they are used mutually to strengthen the actions of clearing heat and removing toxicity; purslane is cold in nature, clear heat and detoxify, clear damp-heat; fructus Cnidii is pungent and bitter in flavor and dry in nature, and has effects of eliminating dampness, dispelling pathogenic wind, killing parasites and relieving itching, and is used as a common drug for treating gynecological pudendum itch and other symptoms, and the above six drugs have effects of clearing heat and removing dampness, dispelling wind and removing toxicity, killing parasites and relieving itching, and are used as ministerial drugs. Hunan radix Angelicae Dahuricae is also a medicinal material in Hunan provincial region, and has effects of eliminating dampness, relieving leukorrhagia, dispelling pathogenic wind, relieving itching, and enhancing the effects of removing dampness, and relieving leukorrhagia when combined with heat-clearing and dampness-removing herbs; the verbena is bitter and cool in taste, enters blood system, promotes blood circulation to promote menstruation, prevents damp and heat from being generated for a long time, and is good in clearing heat and detoxicating to assist the principal and ministerial drugs; peppermint and radix sileris are used as adjuvant drugs for dispelling wind and relieving itching, and the four drugs are used as adjuvant drugs for clearing heat and removing dampness, dispelling wind and relieving itching, and activating blood and resolving stasis. The salix chinensis, eucalyptus leaves, ephedra, basil leaves and houttuynia cordata have the same bitter and cold taste, have the effects of diminishing inflammation, sterilizing, clearing heat and detoxicating, and the anthocyanin quaternary ammonium salt, polysialic acid, polydopamine, antibacterial polypeptide modified chitosan hydrochloride and artesunate hydrochloride are used as traditional Chinese medicine auxiliary additives, and have the functions of resisting oxidation, sterilizing and inhibiting bacteria, promoting wound healing, being good in biocompatibility and degradability and the like, and are used as adjuvant drugs.

In the whole formula, the medicines are combined by bitter and cold, and the medicines are combined to play roles of clearing heat and detoxicating, dehumidifying, killing parasites and relieving itching. Can be used for treating pudendum itch caused by internal accumulation of insect venom and yin burn, with symptoms of pudendum itch, excessive leucorrhea, and yellow and thick color; bacterial, mycotic and trichomonas vaginitis, vulvitis is seen in the above syndromes.

Compared with the prior art, the invention has the beneficial effects that:

1) Under the guidance of the theory and clinical experience of traditional Chinese medicine, the invention selects the raw materials and the proportion thereof, the compatibility accords with the theory of monarch, minister, assistant and guide, the compatibility is precise and appropriate, and the symptoms of pudendum itch, more leucorrhea and yellow and thick color are the symptoms of pudendum itch caused by internal accumulation of insect venom and yin burn.

2) The invention mainly aims at the pudendum itch disease dispatch medicine formula caused by the accumulation of insect venom and yin burn liquid which are common in modern clinic, accords with the basic theory of traditional Chinese medicine, has precise and appropriate compatibility, and has definite curative effect, good safety and no toxic or side reaction.

3) The polysialic acid, polydopamine and antibacterial polypeptide modified chitosan hydrochloride which have good biocompatibility and biodegradability, can promote wound healing, effectively sterilize and antibacterial are added into the traditional Chinese medicine components, so that the use effect of the traditional Chinese medicine is remarkably improved, and the traditional Chinese medicine has the advantages of no toxicity, no harm, no side effect and high safety.

4) The case patient cured by the traditional Chinese medicine composition does not have the phenomenon of repeated illness after being cured.

Detailed Description

In order that those skilled in the art will better understand the technical solution of the present invention, the present invention will be further described with reference to specific examples, but the examples are not intended to limit the present invention.

The Chinese herbal medicine raw materials used in the invention can be purchased from a pharmacy, and other components can be obtained into pharmaceutical products in related suppliers such as national chemical reagents or food additive reagents, and the specification of the pharmaceutical products accords with the national medical standard.

The invention is further illustrated by the following examples:

Example 1

The traditional Chinese medicine composition for treating the pudendum itch is applied to a lotion for treating the pudendum itch, and comprises the following components in parts by weight: 20-30 parts of kuh-seng, 20-30 parts of phellodendron amurense, 20-30 parts of cortex dictamni, 20-30 parts of polygonum cuspidatum, 20-30 parts of dandelion, 20-30 parts of wild chrysanthemum flower, 20-30 parts of purslane, 20-30 parts of fructus cnidii, 30-40 parts of radix angelicae sinensis, 20-30 parts of verbena, 10-20 parts of mint and 6-15 parts of radix sileris.

The preferable formula comprises the following components in parts by weight:

24 parts of kuh-seng, 24 parts of phellodendron amurense, 24 parts of cortex dictamni, 24 parts of polygonum cuspidatum, 24 parts of dandelion, 24 parts of wild chrysanthemum flower, 24 parts of purslane, 24 parts of fructus cnidii, 32 parts of radix angelicae, 24 parts of verbena, 16 parts of mint and 8 parts of radix sileris.

Preparation method examples

The lotion for treating pruritus vulvae is prepared by the following steps of dispensing 24 parts of radix sophorae flavescentis, 24 parts of cortex phellodendri, 24 parts of cortex dictamni, 24 parts of polygonum cuspidatum, 24 parts of dandelion, 24 parts of wild chrysanthemum, 24 parts of purslane, 24 parts of fructus cnidii, 32 parts of radix angelicae, 24 parts of verbena, 16 parts of peppermint and 8 parts of radix saposhnikoviae according to parts by weight, adding 8 times of water, soaking for 0.5 hour, decocting for 1.5 hours for the first time, adding 6 times of water for 1 hour for the second time, merging decoctions, filtering, concentrating the filtrate under reduced pressure, wherein the concentration temperature is 55 ℃, and the concentrated relative density is more than or equal to 1.05; adding 0.3% sodium benzoate, stirring, packaging, and bottling.

Example 2

A Chinese medicinal composition for treating pruritus vulvae comprises: the Chinese herbal medicine comprises the following components in parts by weight: 24 parts of kuh-seng, 24 parts of phellodendron amurense, 24 parts of cortex dictamni, 24 parts of polygonum cuspidatum, 24 parts of dandelion, 24 parts of wild chrysanthemum flower, 24 parts of purslane, 24 parts of fructus cnidii, 32 parts of radix angelicae, 24 parts of verbena, 16 parts of peppermint, 8 parts of radix sileris, 4 parts of salix, 3 parts of eucalyptus leaves, 4 parts of ephedra, 2 parts of anthocyanin quaternary ammonium salt, 3 parts of basil leaves, 5 parts of houttuynia cordata, 12 parts of polysialic acid, 25 parts of polydopamine, 4 parts of antibacterial polypeptide modified chitosan hydrochloride and 1 part of artesunate hydrochloride.

A preparation method of a traditional Chinese medicine composition for treating pruritus vulvae based on the above method comprises the following steps:

(1) Weighing radix Sophorae Flavescentis, cortex Phellodendri, cortex Dictamni Radicis, rhizoma Polygoni Cuspidati, herba Taraxaci, flos Chrysanthemi Indici, herba Portulacae, fructus Cnidii, radix Angelicae Dahuricae, herba Verbenae, herba Menthae, and radix Saposhnikoviae, soaking in 8 times of water for 0.5 hr, decocting for 1.5 hr for the first time, and decocting for 1.0 hr for the second time to obtain decoction A;

(2) Weighing salix chinensis, eucalyptus leaf, ephedra, basil leaf and houttuynia cordata according to the formula proportion, soaking in 6 times of water for 0.5 hour, decocting for 1.5 hours for the first time, decocting in 4 times of water for 1.0 hour for the second time, cooling to room temperature, adding anthocyanin quaternary ammonium salt, polysialic acid and polydopamine, and stirring uniformly to obtain decoction B;

(3) Mixing the decoction A and the decoction B, filtering to obtain filtrate, leaching the filter residue with 1-2 times of water, filtering, mixing the filtrate with the washing liquid, and concentrating the mixed solution at low temperature under reduced pressure to 1/2 of the volume of the original filtrate;

(4) Adding sodium benzoate with the mass of 0.8% into the concentrated solution, stirring uniformly, mixing the antibacterial polypeptide modified chitosan hydrochloride and artesunate hydrochloride, adding into the concentrated solution, stirring uniformly again, filtering, and filling and bottling the filtrate.

The beneficial effects of the invention are as follows: the traditional Chinese medicine composition mainly aims at the pudendum itch disease dispatch medicine composition which is caused by the accumulation of insect venom and yin burn liquid and is common in modern clinic, accords with the basic theory of traditional Chinese medicine, has precise compatibility, and has definite curative effect, good safety and no toxic or side effect. The traditional Chinese medicine decoction pieces are prepared into the lotion, so that the lotion is convenient to store and use, quick in effect and easy to carry, can improve the medication compliance of patients, and has the cure rate of more than 94%. The pharmaceutical research results show that the preparation process of the product is feasible, the quality is controllable, and the product is stable. In addition, the product has better market competitiveness through searching the varieties on the market without the same prescription.

The invention is further illustrated in the following in connection with specific example 1:

clinical trial

1. Clinical data

1.1 Female patients with gynecological pruritus vulvae (internal toxic insect fluid is burnt in yin fluid) and sexual life in 2022, 12 months to 2023, 12 months are randomly divided into an observation group and a control group, and 50 cases are respectively treated. The age of the observation group was 23 to 58 years, and the average age (36.5.+ -. 7.5) was. The control group was aged 23-58 years with an average age (35.9.+ -. 6.4). The difference between the general data of the two groups of patients is not statistically significant (P > 0.05), and the two groups of patients are comparable. Female patients with pruritus vulvae (downward flow of damp-heat) with sexual life are randomly divided into an observation group and a control group, 50 cases each. The age of the observation group was 23 to 50 years, and the average age (30.5.+ -. 4.5) years. The control group was aged 23-50 years with an average age (29.5.+ -. 5.4). All patients are subjected to strict examination and diagnosis, and the medicine is not contraindicated and accords with related diagnosis standards: as a result ①, a large amount of abnormal secretions appear in the vagina of the patient, and the vagina is painful and burnt, pruritus symptoms appear in the vulval part, such as worm-ant shape, even odd itching and hard, the pudendum skin becomes white, thickened or atrophic, even chapped and broken, and dyspareunia appears in the normal intercourse process; ② Abnormal secretions present inside the vagina of the patient are colored in a rock yellowish green, sticky and foul, in the form of foam or bean curd residue, and are accompanied by unpleasant fishy smell.

1.2 Diagnostic criteria

All patients are subjected to strict examination and diagnosis, and the medicine is not contraindicated and accords with the relevant diagnosis standard. ① history of disease: has bad hygiene habit, large amount of leukorrhagia, long-term stimulation of external pudendum, or history of vulva and colpitis; ② Clinical manifestations: itching of the vagina is not tolerated, sitting and lying down can be carried out easily, and the itching can be caused around the anus or inside the thigh; ③ Gynecological examination: rough skin of the vulva, scratch, pigment reduction, even chapping, huang Shuilin drips; ④ Laboratory examination: normal or visible candida, trichomonas, positive bacterial vaginosis, etc.

1.3 Inclusion criteria

① Women between 18 and 50 years of age; ② The secretion is increased, and peculiar smell or pruritus vulvae or causalgia are caused; ③ Clinical and laboratory tests prove that the medicine meets the diagnostic criteria of vulvovaginitis or colpitis; ④ No severe systemic or chronic disease; ⑤ The purpose of the study was understood and informed consent was signed.

1.4 Exclusion criteria

① In gestation or lactation; ② Women during menstrual periods; ③ Acute onset stage of diabetes or other serious chronic diseases; ⑤ A non-interviewee; ⑥ Patients with colpitis caused by sexually transmitted diseases such as mycoplasma, chlamydia, gonococcus, etc.

2. Therapeutic method

Bacterial and trichomonas vaginitis: patients in the control group were treated with single metronidazole 2 times/d, 0.4 g/time, and 1 course of treatment was followed for 1 week. The patient in the observation group adopts vaginal lotion, 80ml of lotion is treated, boiled water is heated according to the ratio of 1:1, and the vaginal douche of the vulva is carried out for 1 time a day; adding hot water into the Chinese medicinal materials, fumigating and washing for 1 time a day; 1 week is a course of treatment. Other medications are disabled during treatment, prohibiting sexual life.

Mycotic vaginitis: the control group adopts clotrimazole suppository, 1 granule each time, 1 time a day, and 7d of treatment and vaginal administration. The patient in the observation group adopts vaginal lotion, 80ml of lotion is treated, boiled water is heated according to the ratio of 1:1, and the vaginal douche of the vulva is carried out for 1 time a day; adding hot water into the Chinese medicinal materials, fumigating and washing for 1 time a day; 1 week is a course of treatment. Other medications are disabled during treatment, prohibiting sexual life.

3. Standard of efficacy

The obvious effect is that clinical symptoms of patients are completely eliminated, and pathogen examination is changed into negative; effectively eliminates clinical symptoms of patients basically, and changes pathogen examination into negative; invalidation is not achieved for all of the above criteria. Total effective rate= (significant effect + effective)/total case number x 100%. Vaginal health and inflammation scores were compared before and after treatment of both groups. Wherein, the score of colpitis can be divided into 0-8, the higher the score, the inflammation condition is about serious, the lower the score is divided into 0-3, the lower the score is divided into 4-6, and the higher the score is divided into 7-8. In the score of vaginal health, the total score is 24 points, the higher the score is, the higher the health degree is, wherein the health degree is lower in 0-8 points, the health degree is medium in 9-16 points, and the health degree is good in >16 points. Comparing the recurrence status and adverse reaction occurrence status of the two groups of diseases.

4. Statistical method

Data were processed using SPSS24.0 statistical software. The measurement data are expressed by mean ± standard deviation (x ± s), and t-test is adopted; count data is expressed as a rate (%) and is tested using x ². P <0.05 indicates that the difference is statistically significant.

5. The results of the clinical test are shown in Table 1.

Table 1 shows the comparison of the two therapeutic effects (n,%) (damp-heat downward flow type)

Note that: ^* P <0.05 compared to control group

Table 2 comparison of vaginal health and inflammation scores (x+ -s, min) before and after treatment (damp-heat downward flow)

Table 3 shows the comparison of the two therapeutic effects (n,%) (the pattern of the interior of insect venom and burn yin-fluid type)

Note that: ^* P <0.05 compared to control group

Table 4 comparison of vaginal health and inflammation scores (x+ -s, min.) before and after treatment (liver-kidney yin deficiency)

The comparison of the two therapeutic effects can be seen in table 1: the total effective rate of the observed group treatment is higher than that of the control group, and the difference is statistically significant (P < 0.05).

Pudendum itch (damp-heat downward flow) was scored by comparing the vaginal health and inflammation before and after treatment of the two groups in table 2: prior to treatment, the two groups of vaginal health and inflammation scores were compared, the differences were statistically significant (P > 0.05); after treatment, the vaginal health and inflammation scores of the observed group were superior to those of the control group, and the differences were statistically significant (P < 0.05).

After the recurrence of the two groups of diseases and the occurrence of adverse reactions are compared with the drug withdrawal for 4 weeks, the recurrence rate of the two groups of patients is observed to be 4.0 percent (2/50) which is lower than 16.0 percent (8/50) of the control group, and the difference is statistically significant (χ ² =4.000, p < 0.05). No significant adverse effects were observed during the treatment period for both groups of patients.

Compared with the treatment effect of pruritus vulvae (the type of yin fluid type of internal accumulation and burn of insect poison): the total effective rate of the observed group treatment is higher than that of the control group, and the difference is statistically significant (P < 0.05). See table 3.

Vaginal health and inflammation score contrast before and after treatment of pruritus vulvae (internal accumulation of insect venom, burn yin fluid): prior to treatment, the two groups of vaginal health and inflammation scores were compared, the differences were statistically significant (P > 0.05); after treatment, the vaginal health and inflammation scores of the observed group were superior to those of the control group, and the differences were statistically significant (P < 0.05). See table 4.

Comparison of recurrence of pruritus vulvae (internal toxic insect retention, burn yin fluid type) and occurrence of adverse reaction: after 4 weeks of withdrawal, the disease recurrence rate was observed to be 4.0% (2/50) lower than 16.0% (8/50) for the control group, with statistical significance for the differences (χ ² =4.000, p < 0.05). No significant adverse effects were observed during the treatment period for both groups of patients.

Typical cases

(1) Someone, female, 32 years old, chenzhou. Pudendum and vagina itching and weakness in the last week, excessive leucorrhea, yellow color, thick texture, foul smell, debilitation of the whole body, thin stool, sticky and greasy urine, reddish tongue with yellow and greasy coating and slippery pulse. Gynecological examination: the vulva is normal, has a small amount of white secretion, has smooth vagina, smooth cervix, and no pressure pain and rebound pain in bilateral accessory areas. Vaginal microecology detection: n-acetyl-beta-amino-galactosylglycanase (+), leucocyte esterase (+), PH value 5.4, mould detection, diagnosis of traditional Chinese medicine: itching of the yin, accumulation of insect-toxin in the yin fluid and burning of the yin fluid. Western diagnosis: colpitis mycotica. The external application of the pharmaceutical composition for treating colpitis, disclosed by the embodiment 1, takes 80ml of washing liquid, heats boiled water according to the ratio of 1:1, and washes the vulva vagina, 1 time a day, 1 week is a treatment course, and symptoms completely disappear after one treatment course of external washing, and the disease is cured.

(2) Some kind of plum, women, 32 years old, chenzhouxian district. As the swimming is performed in the public swimming pool in recent days, the pudendum itch and leucorrhea are more, the device is yellow green, the urine and the stool are normal, the tongue is red, the coating is greasy, and the pulse is wiry and slippery. Gynecological examination: the vulva flushes, the vagina is smooth, yellow green secretion flows out, the cervical is slightly eroded with fishy smell, and the bilateral accessory areas have no tenderness and rebound pain. Vaginal microecology detection: hydrogen peroxide (+), pH 5.1, microscopic examination of leucocyte (+), cleanliness III, clue cell detection, and diagnosis in traditional Chinese medicine: itching of the yin, accumulation of insect-toxin in the yin fluid and burning of the yin fluid. Western diagnosis: bacterial vaginitis. The external application of the pharmaceutical composition for treating colpitis, disclosed by the embodiment 1, takes 80ml of washing liquid, heats boiled water according to the ratio of 1:1, and washes the vulva vagina, 1 time a day, 1 week is a treatment course, and symptoms completely disappear after one treatment course of external washing, and the disease is cured.

(3) Some European, female, 27 years old, chenzhou. The vaginal itching repeatedly attacks in recent years, with the symptoms of pruritus vulvae, a small amount of subjective leucorrhea, white color, no peculiar smell, sometimes soreness of waist, sticky and uncomfortable stool, reddened tongue, greasy coating and wiry and slippery pulse. Gynecological examination: the vulva and vagina are flushed, the vagina is smooth, white bean curd residue-like secretion exists in the vagina, the cervix is smooth, the left accessory is provided with pressing pain and no rebound pain, and the right accessory is provided with (-). Vaginal microecology detection: n-acetyl-beta-amino-galactosylglycanase (+), hydrogen peroxide (+), PH value 5.3, mould detection, diagnosis of traditional Chinese medicine: itching of the yin, accumulation of insect-toxin in the yin fluid and burning of the yin fluid. Western diagnosis: colpitis mycotica. The external application of the pharmaceutical composition for treating colpitis, disclosed by the embodiment 1, takes 80ml of washing liquid, heats boiled water according to the ratio of 1:1, and washes the vulva vagina, 1 time a day, 1 week is a 1-treatment course, and symptoms completely disappear after two treatment courses of external washing, and the disease is cured.

(4) Peng Mou women, 41 years old, chenzhou. The white bands are more abundant in recent half a year, yellow in color, smelly and foul in smell, with slight pruritus vulvae, debilitation, sleepiness, sticky and greasy stool, yellow urine, red and dark tongue with slightly greasy coating, and wiry and slippery pulse. Gynecological examination: the vulva is slightly red and swollen, the vagina is smooth, a large amount of bean curd residue-like secretion exists, the cervical I degree is eroded, the left accessory area is lightly pressed and has no rebound pain, and the right accessory is (-). Vaginal microecology detection: hydrogen peroxide (+), pH 5.1, mold detection, hypha detection, and diagnosis in traditional Chinese medicine: itching of the yin, accumulation of insect-toxin in the yin fluid and burning of the yin fluid. Western diagnosis: colpitis mycotica. The external application of the pharmaceutical composition for treating colpitis, disclosed by the embodiment 1, takes 80ml of washing liquid, heats boiled water according to the ratio of 1:1, performs vulva vaginal irrigation, and takes 1 treatment course for 1 week every day, the symptoms completely disappear after two treatment courses of external washing, the disease is cured, and the vaginal microecology detection is normal after one month.

(5) Liu is somewhere, female, 28 years old. The white leucorrhea is large in plain leucorrhea, white in color and peculiar smell, and is accompanied with vaginal itching and is very bad in nearly two weeks, especially at night, with burning sensation in the yin, chest distress and anorexia, red tongue with white and greasy coating, and wiry and slippery pulse. Gynecological examination: the vulva is slightly red and swollen, white secretion is attached, the vagina is smooth, the cervix uteri is smooth, and the bilateral accessory area has no tenderness and rebound pain. And (3) detecting the vaginal microecology of the outer hospital: and detecting mould. The diagnosis of traditional Chinese medicine is as follows: itching of the yin, accumulation of insect-toxin in the yin fluid and burning of the yin fluid. Western diagnosis: colpitis mycotica. The external application of the pharmaceutical composition for treating colpitis, disclosed by the embodiment 1, takes 80ml of washing liquid, heats boiled water according to the ratio of 1:1, and washes the vulva vagina, 1 time a day, 1 week is a 1-treatment course, and symptoms completely disappear after two treatment courses of external washing, and the disease is cured.

(6) Liu somewhere, woman, 20 years old, chongqing, student, sexual life history. The pruritus vulvae is caused by nearly 3 days, the leucorrhea is subjective, the leucorrhea is white, no peculiar smell exists, the pain is caused by dry mouth and bitter taste, the lower abdomen is painful, the stool is thin, the urine is little yellow, the tongue is red, the tongue coating is yellow and greasy, and the pulse is wiry and slippery. Gynecological examination: the vulva and vagina are red and swollen, a small amount of white secretion is seen in the vagina, the vagina is smooth, the cervical I degree is eroded, and the bilateral accessory area has no tenderness and rebound pain. Vaginal microecology detection: PH 4.8, cleanliness III, clue cell detection. The diagnosis of traditional Chinese medicine is as follows: itching of the yin, accumulation of insect-toxin in the yin fluid and burning of the yin fluid. Western diagnosis: bacterial vaginitis. The external application of the pharmaceutical composition for treating colpitis, disclosed by the embodiment 1, takes 80ml of washing liquid, heats boiled water according to the ratio of 1:1, and washes the vulva vagina, 1 time a day, 1 week is a treatment course, and symptoms completely disappear after one treatment course of external washing, and the disease is cured.

(7) Cao is a certain, female, 35 years old, chenzhou. For 2 years, the pudendum itch is aggravated in nearly 10 days, the leucorrhea is large, the color is yellow, the bean curd residue is like, the odor exists, beriberi exists, the stool is sticky and difficult to solve, the urine is normal, the tongue is reddish, the coating is thick and greasy, and the pulse is wiry and slippery. Gynecological examination: the vulva is normal, the vagina is smooth, the cervix uteri is smooth, and the bilateral accessory area has no tenderness and rebound pain. Vaginal microecology detection: PH value is 4.8, mould is detected, and the diagnosis of traditional Chinese medicine is as follows: itching of the yin, accumulation of insect-toxin in the yin fluid and burning of the yin fluid. Western diagnosis: colpitis mycotica. The external application of the pharmaceutical composition for treating colpitis, disclosed by the embodiment 1, takes 80ml of washing liquid, heats boiled water according to the ratio of 1:1, and washes the vulva vagina, 1 time a day, 1 week is a treatment course, and symptoms completely disappear after one treatment course of external washing, and the disease is cured.

(8) Deng Mou, female, 39 years old. Two weeks after the back of the external travel, the vulva is itchy and burning, such as ant-shaped feeling, a large amount of white bands, foaming, white color, smelly smell, heavy and weak whole body, loose stool, frequent urination, reddish tongue with thick and greasy coating and slippery pulse. Gynecological examination: the vulva is flushed, a small amount of yellow green secretion exists, the vagina is smooth, the cervix is smooth, and the bilateral accessory areas have no tenderness and rebound pain. Vaginal microecology detection: n-acetyl-beta-amino-galactosamine enzyme (+), pH 5.2, trichomonas detection and cleanliness IV degree. The diagnosis of traditional Chinese medicine is as follows: itching of the yin, accumulation of insect-toxin in the yin fluid and burning of the yin fluid. Western diagnosis: trichomonas vaginitis. The external application of the pharmaceutical composition for treating colpitis, disclosed by the embodiment 1, takes 80ml of washing liquid, heats boiled water according to the ratio of 1:1, and washes the vulva vagina, 1 time a day, 1 week is a 1-treatment course, and symptoms completely disappear after two treatment courses of external washing, and the disease is cured.

(9) Some of the plums, women, 45 years old, teachers. The near half month has more bands, yellow color, burning shift, frequent pruritus vulvae, slight peculiar smell, dry mouth, bitter taste, dry stool, yellow urine, red tongue, thin and yellow coating and slippery pulse. Gynecological examination: the vulva and vagina are flushed, the vagina is unobstructed, the cervical is II-degree eroded, the left accessory area is lightly pressed and has no rebound pain, and the right accessory area is not pressed and has no rebound pain. Vaginal microecology detection: leukocyte esterase (+), pH 5.2, cleanliness IV, clue cell detection. The diagnosis of traditional Chinese medicine is as follows: itching of the yin, accumulation of insect-toxin in the yin fluid and burning of the yin fluid. Western diagnosis: bacterial vaginitis. The external application of the pharmaceutical composition for treating colpitis, disclosed by the embodiment 1, takes 80ml of washing liquid, heats boiled water according to the proportion of 1:1, and performs vulva vaginal irrigation, 1 time a day, 1 week is a treatment course, symptoms completely disappear after one treatment course of external washing, the disease is cured, and no recurrence occurs after one month of drug withdrawal following diagnosis.

(10) Li Mou women, 36 years old, leiyang people, staff. Itching, burning sensation, leucorrhea such as water sample, no peculiar smell, debilitation and heaviness, obesity, sticky stool, normal urine, red tongue with thin and yellow coating, wiry and slippery pulse of the vulva in nearly 10 days. Gynecological examination: the vulvar flush is accompanied by slight redness and swelling, the vagina is smooth, the cervix uteri is smooth, and the bilateral accessory area has no tenderness and rebound pain. Vaginal microecology detection: PH 4.6, epithelial cells+. The diagnosis of traditional Chinese medicine is as follows: itching of the yin, accumulation of insect-toxin in the yin fluid and burning of the yin fluid. Western diagnosis: vulvitis. The external application of the pharmaceutical composition for treating vulvitis of the embodiment 1 of the invention takes 80ml of washing liquid, heats boiled water according to the ratio of 1:1, washes the vulva 1 time a day, takes 1 week as a treatment course, completely eliminates symptoms after one treatment course of external washing, cures diseases, and orders to wear the pure cotton loose trousers during the period.

In the invention, the traditional Chinese medicine composition is prepared by carefully selecting the raw materials and the proportion thereof under the guidance of the theory and clinical experience of the traditional Chinese medicine, and the compatibility accords with the theory of monarch, minister, assistant and guide, the compatibility is precise and appropriate, and the symptoms of pruritus vulvae, large amount of leucorrhea and yellow and thick color are caused by the accumulation of the insect venom in the middle warmer and the burning of yin liquid; the invention mainly aims at the pudendum itch disease dispatch medicine formula caused by the accumulation of insect venom and yin burn liquid which are common in modern clinic, accords with the basic theory of traditional Chinese medicine, has precise and appropriate compatibility, and has definite curative effect, good safety and no toxic or side reaction after clinical application of the prescription for years; the polysialic acid, polydopamine and the antibacterial polypeptide modified chitosan hydrochloride which have good biocompatibility and biodegradability, can promote wound healing, effectively sterilize and antibacterial are added into the traditional Chinese medicine components, so that the use effect of the traditional Chinese medicine is remarkably improved, and the traditional Chinese medicine has the advantages of no toxicity, no harm, no side effect and high safety; the case patient cured by the traditional Chinese medicine composition does not have the phenomenon of repeated illness after being cured.

Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A traditional Chinese medicine composition for treating pruritus vulvae, which is characterized by comprising the following components: the Chinese herbal medicine comprises the following components in parts by weight: 20-30 parts of kuh-seng, 20-30 parts of phellodendron amurense, 20-30 parts of cortex dictamni, 20-30 parts of polygonum cuspidatum, 20-30 parts of dandelion, 20-30 parts of wild chrysanthemum flower, 20-30 parts of purslane, 20-30 parts of fructus cnidii, 30-40 parts of radix angelicae sinensis, 20-30 parts of verbena, 10-20 parts of mint and 6-15 parts of radix sileris.

2. The traditional Chinese medicine composition for treating pruritus vulvae according to claim 1, wherein the traditional Chinese medicine composition further comprises: 3-8 parts of salix chinensis, 2-5 parts of eucalyptus leaves, 2-6 parts of ephedra, 1-4 parts of anthocyanin quaternary ammonium salt, 2-4 parts of basil leaves, 2-7 parts of cordate houttuynia, 5-18 parts of polysialic acid and 10-30 parts of polydopamine.

3. The traditional Chinese medicine composition for treating pruritus vulvae according to claim 2, wherein the traditional Chinese medicine composition further comprises: 2-5 parts of antibacterial polypeptide modified chitosan hydrochloride.

4. The traditional Chinese medicine composition for treating pruritus vulvae according to claim 3, wherein the traditional Chinese medicine composition further comprises: artesunate hydrochloride 1-1.5 parts.

5. The traditional Chinese medicine composition for treating pudendum itch according to claim 4, wherein the traditional Chinese medicine composition comprises 24 parts of kuh-seng, 24 parts of cortex phellodendri, 24 parts of cortex dictamni, 24 parts of polygonum cuspidatum, 24 parts of dandelion, 24 parts of flos chrysanthemi indici, 24 parts of purslane, 24 parts of fructus cnidii, 32 parts of radix angelicae, 24 parts of verbena, 16 parts of peppermint, 8 parts of radix saposhnikoviae, 4 parts of salix, 3 parts of eucalyptus, 4 parts of ephedra, 2 parts of anthocyanin quaternary ammonium salt, 3 parts of basil leaf, 5 parts of houttuynia cordata, 12 parts of polysialic acid, 25 parts of polydopamine, 4 parts of antibacterial polypeptide modified chitosan hydrochloride and 1 part of artesunate hydrochloride.

6. A method for preparing a traditional Chinese medicine composition for treating pruritus vulvae according to any one of claims 1-5, comprising the following steps:

7. A lotion formulation for treating pruritus vulvae prepared from the traditional Chinese medicine composition according to any one of claims 1 to 4.

8. The use of a Chinese medicinal composition according to any one of claims 1-4 in the preparation of a medicament for treating pruritus vulvae.

9. The use of a Chinese medicinal composition according to any one of claims 1-4 in the preparation of a medicament for the treatment of vaginitis.