CN118216508A - A compound mosquito larvae killing composition and its application - Google Patents
A compound mosquito larvae killing composition and its application Download PDFInfo
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- CN118216508A CN118216508A CN202211647687.9A CN202211647687A CN118216508A CN 118216508 A CN118216508 A CN 118216508A CN 202211647687 A CN202211647687 A CN 202211647687A CN 118216508 A CN118216508 A CN 118216508A
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Abstract
The invention discloses a compound mosquito-killing larva composition and application thereof, wherein the compound mosquito-killing larva composition comprises 1-5% of active ingredient, 0-5% of liquid original drug adsorbent and 2-8% of slow-release coating agent (1-4 comprises active ingredient A and active ingredient B, wherein the active ingredient A is a piperonic acid derivative compound, the active ingredient B is selected from any one of pyriproxyfen, phoxim, dithiophos, fenoxycarb, S-methoprene, dinotefuran, thiamethoxam, acetamiprid, imidacloprid, nitenpyram, cyantraniliprole and chlorantraniliprole.
Description
Technical Field
The invention relates to a sanitary insecticide, in particular to a compound mosquito-killing young composition containing piperic acid derivative compounds and application thereof.
Background
Mosquitoes are the most familiar and main sanitary pests, and the mosquito control generally adopts the means of environmental control, biological control, chemical control and the like. Chemical control is a relatively large number of control methods currently in use. The outdoor space spraying which is commonly used for killing adult mosquitoes can rapidly reduce the density of the mosquitoes. The mosquito larva killing method is also an important auxiliary measure for controlling mosquitoes, and outdoor ponding places such as waste tires, cement grounds, fireproof barrels, sewage ditches, septic tanks, catch basins and the like are extremely easy to breed mosquito larva, can not remove or can not remove ponding at one time, and can kill the mosquito larva by using chemical means.
At present, mosquito larvae control mainly comprises two major types, namely hormone products, wherein the effect of killing mosquitoes is achieved by inhibiting normal molting or eclosion of mosquito larvae, and the other type of products directly kills the larvae by contact killing or stomach poisoning, so that the control purpose is achieved.
At present, the single dosage is still mainly used for preventing and treating mosquito larvae in China, and the effective components comprise pyriproxyfen, dithiophosphate, fenthion, methyl pyrimidine phosphorus, ethofenprox, imidacloprid, bacillus thuringiensis, bacillus sphaericus, S-methoprene and the like, so that the number of the compounded registration is small. The long-term single use of one medicament for preventing and controlling mosquito larvae inevitably leads mosquito larvae to generate certain drug resistance to part of medicaments, so that the preventing and controlling effect of the medicaments can be greatly reduced.
The Chinese patent CN112457288 discloses a piperic acid derivative and application thereof, wherein the compound I-72 has contact killing and stomach poisoning activities and good conduction activities, and can be used for preventing and controlling various pests such as lepidoptera, hemiptera, thysanoptera, coleoptera and the like. The structural formula of the compound is as follows:
At present, the mosquito larvae prevention and control method still takes granules as main materials, and the preparation of the granules mainly adopts a carrier coating method and a carrier adsorption method. The coating method is that solid raw medicine is coated on a carrier to prepare granules, and liquid raw medicine cannot be directly coated; the adsorption method mainly adopts a porous carrier to adsorb the liquid raw medicine, the solid raw medicine cannot be directly adsorbed, the raw medicine is simply adsorbed on the carrier, and the medicine is released quickly after the medicine is applied, so that the lasting effect is poor. The invention adopts the adsorbent to adsorb the liquid raw medicine, and the active ingredients are coated on the surface of the carrier through the slow-release coating agent, so that the problem that the liquid raw medicine cannot be coated is solved, and the slow-release effect is achieved.
Experiments show that the piperic acid derivative compound and part of pesticide are compounded to have synergistic effect on preventing and controlling mosquito larvae of sanitary pests, so that the problem of drug resistance of the mosquito larvae to single-agent long-term use can be effectively alleviated, the preventing and controlling effect is improved, the duration of effect is long, and the sustained-release effect is realized.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a compound mosquito-killing larva composition and application thereof, wherein a piperic acid derivative compound is compounded with part of insecticide, the two active ingredients are compounded, the insecticidal effect is good, and the dual mechanism is compounded to have synergy, has a slow release effect and is not easy to generate drug resistance.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
The invention firstly provides a compound mosquito-killing larva composition, wherein an active ingredient is formed by compounding an active ingredient A and an active ingredient B, the total weight of the active ingredient A and the active ingredient B accounts for 1-5% of the compound mosquito-killing larva composition by weight, and the balance is an auxiliary agent;
the active ingredient A is a piperic acid derivative compound shown in the formula I (compound I-72 for short);
the active ingredient B is selected from any one of pyriproxyfen, phoxim, dithiophosphate, fenoxycarb, S-methoprene, dinotefuran, thiamethoxam, acetamiprid, imidacloprid, nitenpyram, cyantraniliprole and chlorantraniliprole;
in the technical scheme, the weight ratio of the active ingredient A to the active ingredient B is 1: 12-12: 1.
In the technical scheme, the weight ratio of the piperonic acid derivative compound to the pyriproxyfen is 1:2 to 4:1.
In the technical scheme, the weight ratio of the piperic acid derivative compound to the phoxim is 1: 8-4: 1.
In the technical scheme, the weight ratio of the piperic acid derivative compound to thiamethoxam is 1:2 to 6:1.
In the technical scheme, the auxiliary agent comprises a liquid raw medicine adsorbent, a slow-release coating agent and a carrier; the compound mosquito-killing larva composition is in the form of granules; the granules comprise the following components in percentage by weight: 1 to 5 percent of active ingredient, 0 to 5 percent of liquid raw medicine adsorbent, 2 to 8 percent of slow release coating agent and carrier complement to 100 percent.
In the technical scheme, the 2% -8% of slow-release coating agent comprises 1% -4% of dispersing agent, 0.5% -2% of wetting agent and 0.5% -2% of binder.
In the technical scheme, the liquid raw material adsorbent is selected from one of white carbon black, diatomite, attapulgite and bentonite.
In the above technical scheme, the dispersant is selected from: sodium alkylbenzenesulfonate, sodium naphthalene sulfonate formaldehyde condensate, sodium methylene dinaphthyl sulfonate, sodium naphthalene sulfonate, sodium lignin sulfonate and sodium polyacrylate.
In the above technical solution, the wetting agent is selected from: sodium butylnaphthalene sulfonate, sodium dodecyl sulfate, sodium fatty acid ester sulfate, alkylphenol ethoxylate-50, and sodium dihydroxybiphenyl sulfonate.
In the above technical solution, the binder is selected from: one of polyvinyl acetate, polyvinyl alcohol, sodium carboxymethyl cellulose, gum arabic and sodium silicate.
In the above technical solution, the carrier is selected from: silica sand, quartz sand, marble, and granular calcium carbonate.
The invention also provides a preparation method of the compound mosquito-killing larva composition, which comprises the following steps:
(1) The dispersing agent, the wetting agent and the binding agent in weight percentage are mixed with a proper amount of water to prepare the slow-release coating agent (the water is dried in the later period, so the dosage is not particularly limited, and the dispersing agent, the wetting agent and the binding agent can be fully dissolved);
(2) If the active ingredient B is solid, uniformly mixing the active ingredient A and the active ingredient B in percentage by weight, and carrying out jet milling and mixing for later use; if the active ingredient B is liquid, adsorbing the active ingredient B with a liquid raw material adsorbent into powder, uniformly mixing the powder with the active ingredient A with the weight percentage, and carrying out air flow crushing and mixing for later use;
(3) Mixing the carrier with the slow-release coating agent according to the weight percentage, and then stirring and coating the mixture to ensure that the slow-release coating agent is uniformly coated on the surface of the carrier; then, the powder obtained in the step (2) is put into a carrier coated with a slow-release coating agent, and the particles are obtained after full stirring and coating; and finally, drying the coated granules to obtain granules.
The invention firstly provides an application of the compound mosquito larva killing composition in killing sanitary pests on breeding places of mosquito larvae.
In the technical scheme, the sanitary insect is mosquito larva.
In the technical scheme, the mosquito larva breeding places are sewage ditches, sewer and other places.
The technical scheme of the invention has the advantages that: the compound mosquito-killing larva composition has good insecticidal effect, is compounded by a double mechanism to have synergism, has a slow release effect and is not easy to generate drug resistance.
Detailed Description
The following detailed description of the technical scheme of the present invention is provided, but the present invention is not limited to the following descriptions:
the percentages in the examples below refer to weight percentages unless otherwise indicated.
The invention is illustrated below with reference to specific examples.
Formulation example 1:1.2% Compound I-72. Pyriproxyfen granule
Compound I-720.8%, pyriproxyfen 0.4%, sodium alkyl benzene sulfonate 3%, sodium butyl naphthalene sulfonate 1%, polyvinyl acetate 1% and silica sand to 100%.
Formulation example 2:2% compound I-72. Pyriproxyfen granule
The compound I-721%, pyriproxyfen 1%, naphthalene sodium sulfonate formaldehyde condensate 4%, sodium dodecyl sulfate 2%, polyvinyl alcohol 1.5% and quartz sand to 100%.
Formulation example 3:5% compound I-72. Times thiophosphorus granule
The composition comprises compound I-721%, phosphorus bisulfide 4%, sodium naphthalene sulfonate 4%, sodium fatty acid ester sulfate 2%, white carbon black 5%, sodium carboxymethylcellulose 2% and marble 100%.
Formulation example 4:3% compound I-72. Times thiophosphorus granule
The compound I-721.5%, phosphorus bisulfide 1.5%, sodium lignin sulfonate 2.5%, alkylphenol ethoxylate-501.5%, diatomite 3%, gum arabic 1.5% and granular calcium carbonate to 100%.
Formulation example 5:3.5% Compound I-72. Dithiophosphate granule
The compound I-720.5%, phosphorus disulfide 3%, sodium polyacrylate 4%, dihydroxydiphenyl sodium sulfonate 1%, attapulgite 3.5%, sodium silicate 1.5% and quartz sand to 100%.
Formulation example 6:4% compound I-72. Dithiophosphate granule
The composition comprises compound I-721.5%, phosphorus disulfide 2.5%, naphthalene sulfonate formaldehyde condensate 2.5%, alkylphenol ethoxylate-501.5%, bentonite 4%, polyvinyl alcohol 1% and granular calcium carbonate 100%.
Formulation example 7:4% compound I-72 fenoxycarb granule
Compound I-721%, fenoxycarb 3%, sodium lignin sulfonate 2.5%, sodium dodecyl sulfate 2%, polyvinyl acetate 1% and marble 100%.
Formulation example 8:2% of compound I-72. Fenoxycarb granule
Compound I-720.5%, fenoxycarb 1.5%, sodium polyacrylate 2%, sodium fatty acid ester sulfate 0.5%, sodium carboxymethylcellulose 0.5% and silica sand to 100%.
Formulation example 9:1% compound I-72.S-methoprene granule
The compound I-720.5%, S-methoprene 0.5%, sodium alkyl benzene sulfonate 1%, sodium butyl naphthalene sulfonate 0.5%, diatomite 2%, gum arabic 0.5% and quartz sand up to 100%.
Formulation example 10:1.5% Compound I-72.S-Enbenomyl granule
The compound I-721%, S-methoprene 0.5%, sodium polyacrylate 1.5%, sodium fatty acid sulfate 1%, attapulgite 2.5%, sodium silicate 2% and granular calcium carbonate to 100%.
Formulation example 11:1.6% compound I-72 dinotefuran granules
Compound I-721.2%, dinotefuran 0.4%, sodium lignin sulfonate 1.5%, dihydroxybiphenyl sodium sulfonate 1%, polyvinyl alcohol 0.8% and marble up to 100%.
Formulation example 12:2.4% Compound I-72 dinotefuran granules
The compound I-720.8%, dinotefuran 1.6%, sodium naphthalene sulfonate 3.5%, alkylphenol ethoxylate-501.5%, gum arabic 1.2% and quartz sand to 100%.
Formulation example 13:2% compound I-72 thiamethoxam granule
The compound I-721%, thiamethoxam 1%, methylene dinaphthyl sodium sulfonate 2.5%, butyl naphthalene sodium sulfonate 1%, gum arabic 0.8% and quartz sand accounting for 100%.
Formulation example 14:1.8% Compound I-72 thiamethoxam granule
The composition comprises compound I-720.6%, thiamethoxam 1.2%, sodium polyacrylate 3%, sodium dodecyl sulfate 1%, sodium silicate 1% and granular calcium carbonate to 100%.
Formulation example 15:3.2% Compound I-72 acetamiprid granule
Compound I-720.8%, acetamiprid 2.4%, sodium naphthalene sulfonate 4%, dihydroxydiphenyl sodium sulfonate 2%, sodium silicate 1.5% and granular calcium carbonate to 100%.
Formulation example 16:1.4% Compound I-72 acetamiprid granule
Compound I-720.7%, acetamiprid 0.7%, sodium alkyl benzene sulfonate 2.5%, sodium butyl naphthalene sulfonate 0.5%, polyvinyl acetate 0.6% and marble accounting for 100%.
Formulation example 17:2.5% Compound I-72 imidacloprid granules
Compound I-720.5%, imidacloprid 2%, sodium polyacrylate 3.5%, sodium dodecyl sulfate 0.6%, gum arabic 1.2% and silica sand to 100%.
Formulation example 18:3% compound I-72 imidacloprid granules
The compound I-721%, imidacloprid 2%, naphthalene sodium sulfonate formaldehyde condensate 4%, dihydroxybiphenyl sodium sulfonate 1.5%, polyvinyl acetate 1.2% and granular calcium carbonate to 100%.
Formulation example 19:3.6% of compound I-72 nitenpyram granules
The chemical compound I-721.2%, nitenpyram 2.4%, sodium lignin sulfonate 4%, sodium fatty acid ester sulfate 2%, sodium carboxymethylcellulose 1.5% and quartz sand to 100%.
Formulation example 20:1.2% of compound I-72 nitenpyram granule
Compound I-720.8%, nitenpyram 0.4%, sodium polyacrylate 3%, dihydroxybiphenyl sodium sulfonate 1%, sodium silicate 1% and marble 100%.
Formulation example 21:3.3% of compound I-72 cyantraniliprole granules
The compound I-722.2%, cyantraniliprole 1.1%, methylene dinaphthyl sodium sulfonate 2.5%, fatty acid ester sodium sulfate 1.5%, gum arabic 1.1% and granular calcium carbonate to 100%.
Formulation example 22:1.5% compound I-72 cyantraniliprole granule
Compound I-720.5%, cyantraniliprole 1%, sodium lignin sulfonate 2.5%, alkylphenol ethoxylate-500.5%, sodium carboxymethylcellulose 0.8% and quartz sand to 100%.
Formulation example 23:1.2% Compound I-72 Chlorantraniliprole granule
The compound I-720.9%, chlorantraniliprole 0.3%, sodium naphthalene sulfonate 3%, sodium butylnaphthalene sulfonate 1%, polyvinyl alcohol 1% and silica sand to 100%.
Formulation example 24:4.5% Compound I-72 Chlorantraniliprole granule
The compound I-721.5%, chlorantraniliprole 3%, methylene dinaphthyl sodium sulfonate 3.5%, fatty acid ester sodium sulfate 2%, sodium carboxymethylcellulose 2% and granular calcium carbonate to 100%.
Application example 1: drug efficacy test for preventing and controlling mosquito larvae
Test target: culex light color larva at 3 years old and at last 4 years old
The test method comprises the following steps: adding 5L of dechlorinated water into a plastic barrel, weighing granules, putting into a water body to enable the concentration of active ingredients to be 1mg/L, taking 200mL of the water body into a 250mL beaker after one day, putting 30 culex light-colored larvae, feeding the test insects under the experimental conditions of (25+/-1) DEG C and (60+/-10) percent of relative humidity, repeating for three times, and counting the death number after 7 days. The larvae were treated as dead by gently touching the tweezer tips, either immobile or just tremble, and the larvae had pupated, but were treated as dead by gently touching the tweezer tips, either immobile or just tremble.
Test treatment: preparation examples 1, 3, 7, 9, 13 and 21 treat water bodies with the total concentration of active ingredients of 1mg/L;
Control 1:5% of the compound I-72 granule (prepared by the method of the preparation example 1) is diluted to 1mg/L;
Control 2:5% pyriproxyfen granules (prepared according to the method of formulation example 1 of the present invention) were diluted to 1mg/L;
control 3:5% of the phoxim granules (prepared by the method of the preparation example 3) are diluted to 1mg/L;
control 4:5% fenoxycarb granules (prepared by the method of preparation example 7 according to the invention) are diluted to 1mg/L;
Control 5: 5%S-Enyl ester granule (prepared by the method of the preparation example 9) is diluted to 1mg/L;
control 6:5% thiamethoxam granules (formulated according to the method of formulation example 13) were diluted to 1mg/L;
Control 7:5% cyantraniliprole granules (prepared by the method of preparation example 21 according to the invention) are diluted to 1mg/L;
blank control: 200mL of dechlorinated water
Test results show that the lethality of the control samples 1-7 to mosquito larvae is worse than that of the preparation of the invention, and the preparation examples 1, 3, 7, 9, 13 and 21 of the invention have good lethality effect to mosquito larvae. (see Table 1)
Table 1 formulation examples 1, 3, 7, 9, 13, 21 efficacy test against mosquito larvae
| Treatment of | Mortality (%) |
| Formulation example 1 | 98.9 |
| Formulation example 3 | 100 |
| Formulation example 7 | 97.8 |
| Formulation example 9 | 100 |
| Formulation example 13 | 98.9 |
| Formulation example 21 | 97.8 |
| Control 1 | 93.3 |
| Control sample 2 | 91.1 |
| Control sample 3 | 88.9 |
| Control sample 4 | 90 |
| Control 5 | 87.8 |
| Control 6 | 86.7 |
| Control sample 7 | 87.8 |
| Blank control | / |
The other preparation examples are further subjected to the same drug effect test, and the lethal effect is good.
Application example 2: sustained release and effect-sustaining test for preventing and treating mosquito larvae
Test target: culex light color larva at 3 years old and at last 4 years old
The test method comprises the following steps: adding 5L of dechlorinated water into a plastic barrel, weighing granules, putting into a water body to enable the concentration of active ingredients to be 1mg/L, and measuring 200mL of the solution with the water body into a 250mL beaker after standing for 1 day; putting 30 culex pallidum larvae, breeding the test insects under the experimental conditions of (25+/-1) DEG C and (60+/-10) percent of relative humidity, repeating for three times, counting the death number after 7 days, lightly touching the larvae with forceps tips, wherein the larvae are regarded as dead without moving or only trembling, and the larvae are pupated, but lightly touching the larvae with forceps tips, and the larvae are regarded as dead without moving or only trembling. Pouring the water from the plastic bucket with the medicine on the 14 th day, leaving granules, adding fresh dechlorinated water, placing for 1 day, measuring 200mL of water with the medicine into a 250mL beaker, and performing a drug effect test of the same method; similarly, pouring the water body by 29 days, adding fresh dechlorinated water, standing for 1 day, and weighing 200mL of the water body with the medicine into a 250mL beaker for performing a medicine effect test.
Preparing a control sample: the preparation method of the test control sample is as follows: dissolving solid raw medicine with a certain amount of solvent, absorbing solution containing solid raw medicine and liquid raw medicine with porous carrier (zeolite particles), and fully mixing, stirring and absorbing to obtain the granule.
Test treatment: formulation examples 2, 5, 8, 10, 15, 23 treat water to form a total concentration of active ingredients of 1 mg/L;
Control 8: the granules (prepared by a porous carrier adsorption method) with the concentration of the preparation example 2 are diluted to 1mg/L;
control 9: the granules (prepared by a porous carrier adsorption method) with the concentration of the preparation example 5 are diluted to 1mg/L;
Control 10: the granules (prepared by a porous carrier adsorption method) with the concentration of the preparation example 8 are diluted to 1mg/L;
Control 11: the granules (prepared by a porous carrier adsorption method) with the concentration of the preparation example 10 are diluted to 1mg/L;
control 12: the granules (prepared by a porous carrier adsorption method) with the concentration of 15 in the preparation example are diluted to 1mg/L;
Control 13: the granules (prepared by a porous carrier adsorption method) with the concentration of the preparation example 23 are diluted to 1mg/L;
Test results:
Test results show that the preparation has good mortality rate in the lasting period of the 1 st day, the 15 th day and the 30 th day, has a slow-release effect, and the mortality rate of the 15 th day and the 30 th day is better than the mortality rate of the control sample 8-13 on mosquito larvae, and the mortality rate of the control sample 8-13 on the 1 st day is good, but the mortality rate of the active ingredients is relatively high due to the adoption of simple porous carrier adsorption, and the mortality rate of the active ingredients is relatively poor on the 15 th day and the 30 th day; in the preparation examples 2, 5, 8, 10, 15 and 23, the killing effect is good, the duration is good, and the sustained release effect is realized (see table 2)
Table 2 formulation examples 2, 5, 8, 10, 15, 23 slow release efficacy-sustaining test for controlling mosquito larvae
The other preparation examples are further subjected to the same drug effect test, so that the killing effect is good and the lasting effect is good.
Application example 3: outdoor pesticide effect test for breeding ground mosquito larvae
Test target: mosquito larvae
The test method comprises the following steps: in the sewage ditch partition, the medicament is spread into the sewage ditch, and the density reduction rate of 24h mosquito larvae is recorded;
Test treatment: formulation examples 4, 11, 17, 19, 22 were applied at 2g/m 2;
Test results:
the test result shows that the preparation of the invention has obvious effect of killing mosquito larvae, and the density drop rate of the mosquito larvae is high (see table 3)
Table 3 outdoor efficacy test of mosquito larvae on breeding ground
| Treatment of | Density reduction Rate (%) |
| Formulation example 4 | 96.5 |
| Formulation example 11 | 95.8 |
| Formulation example 17 | 96.9 |
| Formulation example 19 | 96.8 |
| Formulation example 22 | 97.1 |
Application example 4: determination of co-toxicity coefficient of Compound I-72 and other active ingredients on mosquito larvae
Test target: culex light color larva at 3 years old and at last 4 years old
The test method comprises the following steps: diluting the medicament into 5-7 concentration gradients by using acetone, sucking 1mL, adding the mixture into a beaker containing 149mL of dechlorinated water, uniformly stirring, and repeating for three times. Then, 30 culex pallidum and 50mL of dechlorinated water are sucked and added into the water body, and a total of 200mL of water body is subjected to a test. The test insects are raised under the experimental conditions of (25+/-1) ℃ and the relative humidity of (60+/-10)%, the death number is counted after 24 hours, the larvae are lightly touched by the nipper tips, the larvae are regarded as dead without moving or only trembling, if the larvae are pupated, but the larvae are lightly touched by the nipper tips, and the larvae are regarded as dead without moving or only trembling.
The data are subjected to a linear weighted regression method to calculate the median lethal concentration value, and the co-toxicity coefficient is calculated by referring to the grand cloud Peel method.
The test result shows that the insecticidal composition has good synergistic effect on the mortality of mosquito larvae after being compounded according to the indoor efficacy test and calculation, and the specific results are shown in the following table:
Table 4 determination of co-toxicity coefficient of Compound I-72 and pyriproxyfen (against culex pallidum larvae)
As shown in table 4, the compounding ratio of the compound I-72 to pyriproxyfen is 1: 6-6: 1, the co-toxicity coefficients for mosquito larvae are all greater than 100, especially when the compounding ratio is 1:2 to 4: when 1, the co-toxicity coefficient exceeds 120, and the synergistic effect is obvious.
Table 5 determination of co-toxicity coefficient of Compound I-72 and Phosphothioate (against culex light-colored larvae)
As shown in Table 5, the compounding ratio of the compound I-72 and the phosphorus sesquioxide is 1: 10-10: 1, the co-toxicity coefficients for mosquito larvae are all greater than 100, especially when the compounding ratio is 1: 8-4: when 1, the co-toxicity coefficient exceeds 120, and the synergistic effect is obvious.
Table 6 determination of co-toxicity coefficient of Compound I-72 and thiamethoxam (against culex light-colored larvae)
As shown in table 6, the compounding ratio of the compound I-72 to thiamethoxam is 1: 6-8: 1, the co-toxicity coefficients for mosquito larvae are all greater than 100, especially when the compounding ratio is 1:2 to 6: when 1, the co-toxicity coefficient exceeds 120, and the synergistic effect is obvious.
Table 7 Compound I-72 and the remaining active ingredient B optimal co-toxicity coefficient (against culex pallidum larvae)
As shown in Table 7, the optimal blending ratio co-toxicity coefficient of the compound I-72 and the rest of the active ingredient B reaches more than 120, and the synergistic effect is obvious.
The foregoing examples are merely illustrative of the technical concept and technical features of the present invention, and are not intended to limit the scope of the present invention. All equivalent changes or modifications made according to the essence of the present invention should be included in the scope of the present invention.
Claims (8)
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| CN101367748A (en) * | 2004-01-28 | 2009-02-18 | 三井化学株式会社 | Amide derivatives and methods for their preparation and use as pesticides |
| CN109206397A (en) * | 2017-06-29 | 2019-01-15 | 沈阳中化农药化工研发有限公司 | A kind of pepper acid derivative and its preparation and application |
| CN112457288A (en) * | 2019-09-06 | 2021-03-09 | 沈阳中化农药化工研发有限公司 | Piperine acid derivative and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101367748A (en) * | 2004-01-28 | 2009-02-18 | 三井化学株式会社 | Amide derivatives and methods for their preparation and use as pesticides |
| CN109206397A (en) * | 2017-06-29 | 2019-01-15 | 沈阳中化农药化工研发有限公司 | A kind of pepper acid derivative and its preparation and application |
| CN112457288A (en) * | 2019-09-06 | 2021-03-09 | 沈阳中化农药化工研发有限公司 | Piperine acid derivative and application thereof |
| WO2021043115A1 (en) * | 2019-09-06 | 2021-03-11 | 沈阳中化农药化工研发有限公司 | Piperic acid derivative and application thereof |
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| CN118058286A (en) * | 2023-12-08 | 2024-05-24 | 沈阳中化农药化工研发有限公司 | A pesticide preparation containing piperic acid derivatives |
| CN118058286B (en) * | 2023-12-08 | 2025-05-16 | 沈阳中化农药化工研发有限公司 | Pesticide preparation containing piperic acid derivative |
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Denomination of invention: A compound mosquito larvicidal composition and its application Granted publication date: 20250429 Pledgee: Industrial and Commercial Bank of China Yangzhou Branch Pledgor: JIANGSU YANGNONG CHEMICAL Co.,Ltd. Registration number: Y2025980067927 |