CN118162225A - Pipettor, sample adding device and immunoassay appearance - Google Patents

Abstract

The application discloses a pipette, a sample adding device and an immunoassay analyzer. In the liquid dispenser, the nut is arranged into an integrated structure, namely is in threaded connection with the screw rod and is connected with the first end of the plug rod, so that the nut can move along the axial direction of the screw rod under the drive of the drawing and discharging driving device, and the plug rod is driven to move relative to the plug body so as to realize liquid drawing or liquid discharge. The nut is prevented from being installed on the special transmission block to install the nut and the connecting plug rod in the existing pipettor, so that the whole size of the pipettor can be effectively compressed, the space utilization rate of the pipettor is improved, the assembly steps of the pipettor are simplified, the assembly efficiency is improved, and the production cost is reasonably controlled.

Description

Pipettor, sample adding device and immunoassay appearance

Technical Field

The application relates to the technical field of sample detection and analysis, in particular to a pipette, a sample adding device and an immunoassay analyzer.

Background

When the immunoassay is carried out on a sample, a transmission block is usually arranged as a transmission part, a nut is arranged on the transmission block, a screw rod is in threaded connection with the nut, and a plug rod of a plunger device is connected with a rotating piece, so that when a driving device drives the screw rod to rotate, the nut can drive the transmission block to move, and then the plug rod is driven to move in the plug body through the movement of the transmission block to realize the suction or the spit injection of the sample. However, the provision of a dedicated driving block increases the number of parts and requires the assembly of the driving block with the nut, which increases the assembly effort and results in low assembly efficiency, while being disadvantageous in terms of cost control.

Disclosure of Invention

The application mainly aims to provide a liquid dispenser, a sample adding device and an immunoassay analyzer, which are used for solving the problem of low assembly efficiency caused by the fact that a special transmission block is required to be arranged on the liquid dispenser in the prior art.

According to one aspect of the present application, there is provided a pipette comprising:

a housing configured to form a mounting cavity;

the drawing and discharging driving module comprises a drawing and discharging driving device, a screw rod and a nut, wherein the drawing and discharging driving device is arranged on the shell, the screw rod is arranged in the mounting cavity, one end of the screw rod is connected with the output end of the drawing and discharging driving device, and the nut is sleeved on the screw rod and is in threaded connection with the screw rod;

The plunger comprises a plug rod and a plug body, wherein the plug body is connected to the shell, and one end of the plug rod extending out of the plug body is connected with the nut.

On the other hand, the application also provides a sample adding device, which comprises the pipette according to any one of the above books.

In still another aspect, the present application also provides an immunoassay analyzer, which includes the sample loading device described above.

According to the application, the nut is arranged into an integral structure which can be connected with the screw rod through threads and the first end of the plug rod, so that the nut can move along the axial direction of the screw rod under the drive of the drawing and discharging driving device, and the plug rod is driven to move relative to the plug body so as to realize liquid drawing or liquid discharging actions. The nut is prevented from being installed on the special transmission block to install the nut and the connecting plug rod in the existing pipettor, so that the whole size of the pipettor can be effectively compressed, the space utilization rate of the pipettor is improved, the assembly steps of the pipettor are simplified, the assembly efficiency is improved, and the production cost is reasonably controlled.

Drawings

The accompanying drawings, which are included to provide a further understanding of the application and are incorporated in and constitute a part of this specification, illustrate embodiments of the application and together with the description serve to explain the application and do not constitute a limitation on the application. In the drawings:

FIG. 1 is a schematic diagram of an immunoassay device according to an embodiment of the present disclosure.

Fig. 2 is a schematic diagram of a cartridge storage unit having an incubation unit, a detection unit, a cartridge scheduling mechanism, and five cartridge bins according to an embodiment of the present disclosure.

Fig. 3 is a schematic diagram of a cartridge storage unit having two incubation units, two detection units, a cartridge scheduling mechanism, and a cartridge having seven cartridge bins according to an embodiment of the disclosure.

Fig. 4 is a schematic diagram of a cartridge storage unit having an incubation unit, a detection unit, and five cartridge bins according to an embodiment of the present disclosure.

Fig. 5 A1 is a schematic diagram of an incubation unit according to an embodiment of the disclosure, and A2 is a schematic diagram of an incubation unit according to another embodiment of the disclosure.

FIG. 6 is a schematic diagram of a reagent card scheduling mechanism according to one embodiment of the present disclosure.

Fig. 7B 1 is a schematic diagram of a second horizontal driving set according to an embodiment of the disclosure, and B2 is another angular schematic diagram of B1.

Fig. 8 is a schematic diagram of a sample transporting unit carrying a sample rack according to an embodiment of the disclosure, and fig. 2 is a schematic diagram of a sample transporting unit according to another embodiment of the disclosure.

Fig. 9 is a schematic diagram of a sample rack separating mechanism according to an embodiment of the disclosure, and D2 is another angular schematic diagram of D1.

FIG. 10 is a schematic diagram of a sample filling unit according to an embodiment of the present disclosure.

Fig. 11 is a schematic view of a portion of a sample filling unit according to an embodiment of the disclosure, and E2 is a cross-sectional view of a portion of the sample filling unit.

Fig. 12 is a schematic diagram of a consumable supply unit according to an embodiment of the disclosure, and fig. 12 is a schematic diagram of a consumable supply unit according to another embodiment of the disclosure.

Detailed Description

It should be noted that, without conflict, the embodiments of the present application and features of the embodiments may be combined with each other. The application will be described in detail below with reference to the drawings in connection with embodiments.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of exemplary embodiments according to the present application. As used herein, the singular is also intended to include the plural unless the context clearly indicates otherwise, and furthermore, it is to be understood that the terms "comprises" and/or "comprising" when used in this specification are taken to specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof.

The relative arrangement of the components and steps, numerical expressions and numerical values set forth in these embodiments do not limit the scope of the present application unless it is specifically stated otherwise. Meanwhile, it should be understood that the sizes of the respective parts shown in the drawings are not drawn in actual scale for convenience of description. Techniques, methods, and apparatus known to one of ordinary skill in the relevant art may not be discussed in detail, but should be considered part of the authorization specification where appropriate. In all examples shown and discussed herein, any specific values should be construed as merely illustrative, and not a limitation. Thus, other examples of the exemplary embodiments may have different values. It should be noted that: like reference numerals and letters denote like items in the following figures, and thus once an item is defined in one figure, no further discussion thereof is necessary in subsequent figures.

Referring to fig. 1, the present application provides an immunoassay analyzer comprising an incubation unit 20, a reagent cartridge storage unit 30, and a reagent card scheduling mechanism 40. The incubation unit 20 is disposed on the workbench 10, and is used for incubating the reagent card 100 filled with the sample. The reagent cartridge storage unit 30 is disposed on the table 10, and is configured to carry a reagent cartridge 90 in which a reagent card 100 is accommodated. The reagent card dispatching mechanism 40 is provided on the table 10, and is used for dispatching the transfer of the reagent card 100.

Referring to fig. 2-5, in one embodiment, the incubation unit 20 is configured with a plurality of incubation bins 21 along a first horizontal direction. The incubation chamber 21 is used for incubating the reagent card 100 filled with the sample to simulate the reaction of the sample with the reagent in the original living environment temperature state. Further, each of the incubation compartments 21 has an incubation access opening for the reagent card 100 to enter and exit the incubation compartment 21. The incubation ports corresponding to the incubation chambers 21 are located on the first side of the incubation unit 20.

Through setting up along first horizontal direction incubation storehouse 21, and will a plurality of incubation storehouse 21 corresponds respectively incubation import and export is located incubation unit 20 first side, so that when carrying out the amplification to incubation unit 20, can directly with a plurality of incubation unit 20 stacks the setting and can realize, thereby only make full use of the available space of analysis appearance in the vertical direction when realizing incubating the productivity and amplifying, avoid area increase, that is, can not increase the volume of analysis appearance in the horizontal direction, lead to the analysis appearance area increase.

Further, in one embodiment, the incubation unit 20 includes an incubation member 22, a heating member 23, and an insulating layer 24. The incubation member 22 is configured to form a plurality of incubation bins 21 along the first horizontal direction, and the heating member 23 is attached to the outer side of the incubation member 22 and can heat the incubation member 22 so that the temperature in the incubation member 22 can be heated to an incubation temperature required for incubating the reagent card 100. The heat preservation layer 24 is wrapped on the outer sides of the incubation member 22 and the heating member 23, and is used for preserving heat of the incubation member 22, so that the incubation member 22 can keep the incubation temperature for incubating the reagent card. Preferably, the heating element 23 is attached to the bottom surface of the incubation element 22. The heating member 23 may be, but not limited to, a heating film, a heating wire, or the like.

In another embodiment, the incubation unit 20 includes an incubation member 22, a cooling fin 26, a heat sink 27, an air duct 28, and a fan 29. The incubation member is configured along the first horizontal direction to form a plurality of incubation bins 21, and the cooling sheet 26 is attached to the outer side of the incubation member 22 and can heat or cool the incubation member 22, so that the temperature of the incubation member 22 can be selectively regulated and controlled according to the incubation temperature requirement of the reagent card 100 and the external environment temperature condition.

The radiator 27 is connected with the cooling fin 26 and can be used for radiating heat generated by the cooling fin 26 during operation, so as to ensure that the heat generated by the cooling fin 26 during operation can be rapidly radiated. Further, the radiator 27 and the cooling fin 26 are both disposed in the air duct 28. The fan 29 is configured to exhaust or supply air to the air duct 28, so that air in the air duct 28 can flow rapidly, and heat generated when the cooling fin 26 works can be dissipated rapidly.

In a specific embodiment, the workbench 10 is provided with one incubation unit 20, and twenty incubation bins 21 are formed on the incubation unit 20 along the first horizontal direction.

In another specific embodiment, the immunoassay device further includes at least two incubation units 20, wherein one incubation unit 20 is disposed above the other incubation unit 20, and the kit storage unit 30 is disposed above the incubation unit 20.

Further, in one embodiment, the reagent cartridge storage unit 30 is provided on a second side of the incubation unit 20, the second side being an adjacent side to the first side. That is, the reagent cartridge storage unit 30 is disposed adjacent to the incubation unit 20.

In another embodiment, the reagent cartridge storage unit 30 is disposed on the incubation unit 20, so that the reagent cartridge storage unit 30 is reasonably prevented from occupying the space of the workbench 10 in the horizontal direction, and the occupied area of the analyzer can be effectively reduced.

Further, the reagent cartridge storage unit 30 is configured with a reagent cartridge magazine 31, the reagent cartridge magazine 31 is used for carrying a reagent cartridge 90, and the reagent cartridge 90 is used for carrying a reagent card 100. The reagent cartridge storage unit 30 has a plurality of reagent cartridge bins 31 along the first horizontal direction, and each reagent cartridge bin 31 can hold one reagent cartridge 90.

Through will reagent cartridge storage unit 30 locates incubation unit 20 top, and a plurality of reagent cartridge storehouse 31 is followed first horizontal direction sets up, thereby when needs are right reagent cartridge storage unit 30 is amplified, can be directly with at least two reagent cartridge storage unit 30 is followed first horizontal direction every two adjacent layout is in incubation unit 20 is last, thereby can make full use of incubation unit 20 top space, and can not increase the space occupation of analysis appearance in the horizontal direction.

Further, the reagent cartridge storage unit 30 is configured to form a reagent cartridge inlet/outlet 33 corresponding to the top of each reagent cartridge compartment 31, which communicates with the inside of the reagent cartridge compartment 31, and the reagent cartridge 90 is assembled and disassembled through the reagent cartridge inlet/outlet 33. Specifically, the reagent cartridge inlet and outlet 33 is formed at the top of the reagent cartridge storage unit 30 corresponding to each reagent cartridge bin 31, so that each reagent cartridge 90 can be assembled and disassembled along the vertical direction, occupation of the side space of the reagent cartridge storage unit 30 in the process of assembling and disassembling the reagent cartridge 90 can be effectively reduced, the space above the reagent cartridge storage unit 30 can be fully utilized to reasonably increase the height of the reagent cartridge 90 along the vertical direction, and accordingly the accommodating capacity of the reagent cartridge 90 is improved, and the frequency of replacing the reagent cartridge 90 is effectively reduced, and higher detection efficiency is realized.

Further, compared with the solution of the reagent cartridge storage unit 30 with the reagent cartridge inlet and outlet 33 opened at the side, the limiting effect on the reagent cartridge 90 can be effectively improved, and the upper end part of the reagent cartridge 90 is exposed out of the reagent cartridge storage unit 30, thereby being more convenient for the operator to visually carry out loading and unloading operations. Further, the cartridge storage unit 30 is configured with a cartridge outlet 32 corresponding to each cartridge compartment 31. The reagent card 100 and the reagent card outlet 32 are used for the supporting member 43 of the reagent card dispatching mechanism 40 to pass through so as to separate the reagent cards 100 carried in the reagent card case 90 one by one.

Further, the reagent card outlet 32 is on the same side as the incubation port. Specifically, the reagent card outlet 32 and the incubation port are both positioned on the first side of the incubation member 22, thereby facilitating the dispatching of the reagent cards 100 by the reagent card dispatching mechanism 40.

Referring to fig. 6-7, further, the reagent card dispatching mechanism 40 is disposed on the first side of the incubation unit 20 and is configured to transfer the reagent card 100 accommodated in the reagent cartridge 90 into the incubation compartment 21. By providing the reagent card dispatching mechanism 40 on the first side of the incubation unit 20, the reagent card dispatching mechanism can be facilitated to transfer the reagent card 100 for sample filling and transfer the sample filled reagent card 100 into one of the incubation compartments 21 for incubation.

Further, the immunoassay analyzer further comprises a detection unit 80, and the detection unit 80 is used for detecting the incubated reagent card 100. The detection unit 80 includes a detection chamber, and a detection inlet and outlet 81 connected to the detection chamber and located on the first side of the incubation unit 20, where the detection inlet and outlet 81 is used for the reagent card 100 to enter and exit the detection chamber.

Further, the reagent card dispatching mechanism 40 includes a first horizontal driving group, a second horizontal driving group and the supporter 43. In one embodiment, the detection unit 80 is disposed on the second side of the incubation unit 20, and the first horizontal driving set may drive the support 43 to move along the first horizontal direction, so as to drive the supported reagent card 100 to reach the detection port 81. The second horizontal driving set may drive the supporting member 43 to move along the second horizontal direction, so as to drive the supported reagent card 100 to enter the detecting unit 80 for detection, and remove the reagent card 100 from the detecting unit 80 after the detection is completed.

In another embodiment, the detection unit 80 is disposed above the incubation unit 20, so that the space above the incubation unit 20 is utilized to avoid occupying the space on the side surface of the incubation unit 20, thereby avoiding increasing the area of the workbench 10 in the horizontal direction, and realizing the space compression of the immunoassay analyzer in the horizontal direction, and reasonably controlling the space occupation of the immunoassay analyzer in the horizontal direction.

In one embodiment, the immunoassay device includes two detection cells 80 disposed along the first horizontal direction. The two detecting units 80 are respectively disposed on the incubation unit 20. By providing two detection units 80, the detection efficiency of the immunoassay device after amplification can be effectively improved.

In one embodiment, the detection principle of the two detection units 80 is the same. Specifically, both of the detection units 80 apply a fluorescence detection technique, or a colloidal gold detection technique, or the like.

In another embodiment, the detection principle of the two detection units 80 is different. Specifically, one of the detecting units 80 employs a fluorescence detecting technique, and the other detecting unit 80 employs a colloidal gold detecting technique.

In other embodiments, the immunoassay device may further include three or more detection units 80 according to the detection requirements.

The first horizontal driving set is used for driving the supporting member 43 to move along the first horizontal direction, the second horizontal driving set is used for driving the supporting member 43 to move along the second horizontal direction, and the supporting member 43 is configured with a supporting portion 431 for supporting the reagent card 100.

In one embodiment, the first horizontal driving set is used to drive the second horizontal driving set and the support 43 to move synchronously along the first horizontal direction.

In another embodiment, the second horizontal driving set is used to drive the first horizontal driving set and the support 43 to move synchronously along the second horizontal direction.

Further, the reagent card dispatching mechanism 40 further includes a first lifting driving set, which is used for driving the supporting member 43 to perform lifting movement, so as to drive the reagent card 100 carried by the supporting member to lift, or drive the supporting portion 431 to limit or release the target reagent card 100.

In one embodiment, the first lifting driving set is disposed at an output end of the first horizontal driving set, the second horizontal driving set is disposed at an output end of the first lifting driving set, and the supporting member 43 is disposed at an output end of the second horizontal driving set.

Further, the supporting member 43 has a first supporting position and a second supporting position along the second horizontal direction under the driving of the second horizontal driving set. The reagent card dispatching mechanism 40 further includes a reagent card transferring case 45, and the reagent card transferring case 45 is used for accommodating the reagent card 100 being transferred, so as to limit and protect the reagent card 100, and prevent the reagent card 100 from falling off during high-speed transfer.

Further, the reagent card transferring box 45 is disposed at the output end of the first lifting driving set and moves synchronously with the second horizontal driving set. When the supporting member 43 is at the first supporting position, the supporting portion 431 extends out of the reagent card transferring case 45. When the supporting member 43 is at the second supporting position, the supporting portion 431 withdraws to the reagent card transferring case 45.

In one embodiment, the support member 43 is provided with a first protrusion 432 and a second protrusion 433, and the first protrusion 432 and the second protrusion 433 are spaced apart from each other to form the support portion 431. Further, the first protrusion 432 is closer to the incubation unit 20 in the second horizontal direction. The first protrusion 432 is configured to limit the supported reagent card 100 during the process of transferring the reagent card 100 from the accommodating cavity 93, the incubation chamber 21, or the detection chamber to the accommodating chamber 453.

The second protruding portion 433 is configured to limit the supporting of the reagent card 100 during the process of transferring the reagent card 100 from the accommodating chamber 453 to the incubation chamber 21, or the detection chamber, or discarding the reagent card 100. Further, the distance between the first protrusion 432 and the second protrusion 433 is greater than the length of the reagent card 100 along the length direction, so that the reagent card 100 can be supported by the support 431 along the length direction.

Further, the reagent card transferring box 45 includes a base 451 and a cover plate 452, the cover plate 452 is covered on the base 451 and is matched with the base 451 to form a containing bin 453, and the reagent card 100 is contained in the containing bin 453 in the transferring process, so as to limit and protect the reagent card 100, thereby realizing high-speed transferring of the reagent card 100 and further improving transferring efficiency of the reagent card 100.

Further, the accommodating chamber 453 is provided with a reagent card inlet and outlet 4531 toward the first side of the incubation unit 20, and the reagent card inlet and outlet 4531 is used for the supporting member 43 to extend out of the accommodating chamber 453 or retract back into the accommodating chamber 453. The support 43 extends out of the receiving compartment 453 and can be used to transfer a reagent card 100 to be picked up into the incubation compartment 21, or into the detection compartment, or to discard the reagent card 100 after detection.

The holding member 43 is retracted to the accommodating chamber 453 to hold a reagent card 100 from the reagent cartridge 90, or hold a reagent card 100 from the incubation chamber 21 after incubation, or hold a reagent card 100 from the detection chamber after detection.

Further, the base 451 is provided with a first sensor 4511, and the first sensor 4511 is configured to detect whether the reagent card 100 carried on the support 43 reaches a specified position.

Further, an elastic structure 4532 is disposed on an inner side wall of the accommodating chamber 453 along the second horizontal direction, and in the process of accommodating the reagent card 100 in the accommodating chamber 453, the elastic structure 4532 pushes the reagent card 100 so that the reagent card 100 is accommodated in a designated position in the accommodating chamber 453, so that the first sensor 4511 is convenient for detecting whether the reagent card 100 reaches the designated position.

Further, the cover 452 is further provided with a sample filling hole 4521. When one of the reagent cards 100 is accommodated in a designated position in the accommodation compartment 453, the sample filling hole 4521 corresponds to a sample filling area on the reagent card 100, so as to facilitate sample filling.

In the first embodiment, the supporter 43 has a rack portion 434, and the rack portion 434 is located at the opposite side or adjacent side of the supporter 431. The second horizontal driving set includes a second horizontal sliding rail 421, a second horizontal driving device 422, a second driving gear 423, and a second horizontal sliding base 424. The reagent card dispatching mechanism 40 includes a second mounting plate 46. The second mounting plate 46 is mounted at the output end of the first lifting driving set, the second horizontal sliding rails 421 and the second horizontal driving devices 422 are respectively mounted on the second mounting plate 46, the second horizontal sliding rails 421 are arranged along the second horizontal direction, the second horizontal sliding seat 424 is slidably arranged on the second horizontal sliding rails 421, the second horizontal sliding seat 424 is connected with the supporting member 43, and the second driving gear 423 is rotatably connected with the output end of the second horizontal driving devices 422 and meshed with the rack portion 434.

Under the guiding and limiting actions of the second horizontal sliding rail 421 and the second horizontal sliding seat 424, and driven by the second horizontal driving device 422 through the second driving gear 423, the supporting member 43 can be stably switched between the first supporting position and the second supporting position.

Further, the second horizontal sliding seat 424 may also be a guide sleeve, and the second horizontal sliding rail 421 is a guide rod adapted to the guide sleeve. Further, the second mounting plate 46 is further provided with a second sensor 461, and the second sensor 461 is configured to detect whether the support 43 moves to the second supporting position.

Further, the second driving gear 423 is located below the reagent card transferring case 45 and near the reagent card inlet 4531, so that the supporting member 43 located at the first supporting position may be more stable under the support of the second driving gear 423.

In a second embodiment, the second horizontal driving set includes a ball screw pair and a driving motor, the ball screw pair includes a screw and a ball nut, the ball nut is connected to the screw and can move along the axial direction of the screw, the supporting member 43 is disposed on the ball nut, and the output end of the driving motor is connected to the screw. The screw is driven by the driving motor to rotate along the rotation axis so that the ball nut moves along the axial direction of the screw, and the bearing piece 43 is driven to switch positions between the first supporting position and the second supporting position.

In a third embodiment, the reagent card dispatching mechanism 40 includes a second mounting plate 46. The second horizontal driving group comprises a driving motor, a fourth driving gear, a fourth driven gear and a belt. The fourth driving gear and the fourth driven gear are respectively rotatably arranged on the second mounting plate 46, the belt is sleeved between the fourth driving gear and the fourth driven gear, the supporting piece 43 is connected with the belt, the driving motor is arranged on the two mounting plates 46, and the fourth driving gear can be driven to rotate to drive the belt to move so that the supporting piece 43 can be switched between the first supporting position and the second supporting position.

In a fourth embodiment, the second horizontal driving set includes a cylinder, and an output end of the cylinder is connected to the supporting member 43 and can drive the supporting member 43 to switch positions between the first supporting position and the second supporting position.

In one embodiment, the first lifting drive set includes a first vertical slide 441, a first vertical slide 442, and a first lifting drive 443. The reagent card dispatching mechanism 40 further includes a first mounting plate 47. The first mounting plate 47 is provided at the output end of the first horizontal driving group. The first vertical sliding rail 441 and the first lifting driving device 443 are respectively mounted on the first mounting plate 47, the first vertical sliding seat 442 is slidably disposed on the first vertical sliding rail 441, and the first vertical sliding seat 442 is also connected with the second mounting plate 46 and the output end of the first lifting driving device 443. The first lifting driving device 443 drives the first vertical sliding seat 442 to move along the first vertical sliding rail 441 to drive the second mounting plate 46 to synchronously lift, so as to drive the second horizontal driving set to synchronously lift.

In one embodiment, the first lifting driving device 443 is a motor, and a screw is connected to an output end of the motor, and the screw is in threaded connection with the first vertical sliding seat 442. The motor drives the screw rod to rotate to drive the first vertical sliding seat 442 to move along the first vertical sliding rail 441.

In another embodiment, the first lifting driving device 443 is an electric push rod, and an output end of the electric push rod is connected to the first vertical sliding seat 442. The electric push rod drives the first vertical sliding seat 442 to move along the first vertical sliding rail 441.

In other embodiments, the first lifting driving device 443 may also be a cylinder, and an output end of the cylinder is connected to the first vertical sliding seat 442. The cylinder drives the first vertical sliding seat 442 to move along the first vertical sliding rail 441.

Further, in one embodiment, the first vertical sliding rail 411 is disposed on a first side of the first mounting plate 47 along a vertical direction, the first lifting driving device 443 is mounted on a second side of the first mounting plate 47, and the first side and the second side are opposite to each other of the first mounting plate 47, so that the first lifting driving device 443 is more stable when driving the second horizontal driving group, the carrier 43, and the reagent card transferring case 45, and meanwhile, by mounting the first lifting driving device 443 on the second side, a space on the second side of the first mounting plate 47 can be effectively utilized.

The first horizontal driving set includes a first horizontal sliding rail 411, a first horizontal driving device 412, and a first horizontal sliding seat 414. The first horizontal sliding rail 411 and the first horizontal driving device 412 are respectively mounted on the workbench 10, the first horizontal sliding rail 411 is disposed along the first horizontal direction, and the first horizontal sliding seat 414 is slidably disposed on the first horizontal sliding rail 411.

Under the guiding and limiting actions of the first sliding rail and the first horizontal sliding seat 414, the first horizontal driving device 412 may drive the first lifting driving group, the second horizontal driving group, the first mounting plate 47, and the second mounting plate 46 to move stably along the first horizontal direction synchronously.

Referring to fig. 2-4, the second side of the incubation unit 20 is further provided with a reagent card discarding structure 25, and the reagent card discarding structure 25 includes a first guide plate 251, a second guide plate 252 and a third guide plate 253. The second guide plate 252 is engaged between the first guide plate 251 and the third guide plate 253 at a first angle inclined with respect to a horizontal plane, and the second guide plate 252 and the first guide plate 251 and the third guide plate 253 are configured to form a discarding passage along which the reagent card 100 is discarded.

The first guide plate 251 is engaged to the left of the second guide plate 252 in the first horizontal direction, and the third guide plate 253 is engaged to the right of the second guide plate 252 in the first horizontal direction.

The first guide plate 251 includes a first guide plate portion 2511 and a first limit plate portion 2512 that are engaged with each other in the second horizontal direction, and the first guide plate portion 2511 is close to the reagent card dispatching mechanism 40. So that the support 43 is configured such that when transferring a reagent card 100 from the first guide plate portion 2511 toward the first stopper plate portion 2512, the reagent card 100 is biased toward the third stopper plate portion 2533 by the first guide plate portion 2511.

The width of the second guide plate 252 in the first horizontal direction is smaller than the width of the reagent card 100 corresponding to the width direction. So that the reagent card 100 will move toward the third guide 253 when the supporter 43 moves downward by the first elevation driving unit. The third guide plate 253 includes a third connecting plate portion 2531, a third guide plate portion 2532, and two third limiting plate portions 2533, wherein the third connecting plate portion 2531 is vertically connected between the second guide plate 252 and the third guide plate portion 2532, and the two third limiting plate portions 2533 are horizontally arranged opposite to each other and are respectively connected to the third guide plate portion 2532.

Further, the third guide plate portion 2532 is disposed to be inclined at a second angle with respect to the horizontal plane. Preferably, the second angle is greater than the first angle so that the discarded reagent card 100 can be more smoothly dropped down.

Referring again to fig. 1-7, in one embodiment, the work flow of the support 43 is as follows: driven by the first horizontal driving set, the support 43 moves to the target reagent cartridge 90;

then, the support member 43 is moved from the second position to the first position by the second horizontal driving unit, and the support portion 431 is located in the movement channel of the support member 43 of the target reagent cartridge 90;

then, the support member 43 is moved upward by the first lifting driving unit to a height such that the target reagent card 100 positioned at the bottom of the accommodating cavity 93 of the reagent cartridge 90 is limited in the support portion 431;

Then, the supporting member 43 is driven by the second horizontal driving set to move from the first supporting position to the second supporting position, and at this time, the supporting portion 431 and the target reagent card 100 supported by it are both located in the accommodating bin 453;

Then, driven by the first lifting driving set, the supporting member 43 and the target reagent card 100 supported by the supporting member move downward by a certain height;

then, driven by the first horizontal driving set, the supporting member 43 drives the target reagent card 100 supported by the supporting member to move to the sample filling position for filling the sample;

Then, the support 43 moves to the outside of the target incubation compartment 21 along the first horizontal direction under the driving of the first horizontal driving group;

Then, under the driving of the second horizontal driving set, the supporting member 43 moves from the second supporting position to the first supporting position again, at this time, the supporting portion 431 is located at the bottom of the target incubation bin 21, and the target reagent card 100 incubates in the target incubation bin 21;

Then, the support 43 moves downward by a certain height under the driving of the first lifting driving set, so that the support 431 does not limit the target reagent card 100 any more;

Then, the bearing 43 is driven by the second horizontal driving set to move from the first supporting position to the second supporting position, and at this time, the bearing 43 is retracted into the accommodating bin 453; after the incubation of the target reagent card 100 is completed, the support 43 moves from the second picking position to the first picking position again under the driving of the second horizontal driving set;

then, the supporting member 43 moves upwards by a certain height under the driving of the first lifting driving set, so that the supporting portion 431 performs supporting and limiting on the target reagent card 100;

Then, the mail is moved again from the first picking position to the second picking position under the drive of the first lifting drive set, and at this time, the target reagent card 100 after incubation is moved from the incubation chamber 21 to the accommodating chamber 453;

then, at least under the cooperation of the first lifting driving set or the first lifting driving set and the first horizontal driving set, the supporting member 43 drives the target reagent card 100 supported by the supporting member to move to the outer side of the detection bin;

Then, under the driving of the second horizontal driving set, the supporting member 43 moves from the second supporting position to the first supporting position, at this time, the supporting portion 431 and the reagent card 100 carried by the supporting portion move into the detecting bin, and the detecting unit 80 detects the reagent card 100 to obtain a detection result;

After the detection, the supporting member 43 moves from the first supporting position to the second supporting position under the driving of the second horizontal driving set, and at this time, the detected reagent card 100 moves into the accommodating groove along with the supporting member 43 again;

then, at least under the cooperation of the first horizontal driving set or the first lifting driving set and the first horizontal driving set, the supporting member 43 drives the reagent card 100 supported by the supporting member to move to the position of the reagent card discarding structure 25;

Then, the mail is moved from the second picking position to the first picking position under the driving of the second horizontal driving set, and in the process, the reagent card 100 supported by the mail drops to the discarding channel;

Then, after the discarding of the reagent card 100 is completed, the supporter 43 is moved from the first picking position to the second picking position by the driving of the second horizontal driving set.

Referring to fig. 1, the immunoassay analyzer further includes a sample transfer unit 50 and a sample loading device 60. The loading device 60 may be used to load the sample delivered by the sample delivery unit 50 into the reagent card 100.

Referring to fig. 8-9, the sample transporting unit 50 is configured to transport the sample rack 200 carrying the sample containers 210 along the first horizontal direction, where the sample containers 210 hold samples.

In one embodiment, the sample rack 200 may carry a plurality of the sample containers 210, each of the sample containers 210 may hold one type of sample, or a portion of the sample containers 210 may hold one type of sample, or all of the sample containers 210 on the sample rack 200 may hold the same type of sample, respectively. Specifically, the number of sample containers 210 placed on one of the sample holders 200, and the type of sample contained in each sample container 210, may be selected according to the detection requirements.

Further, the sample delivery unit 50 includes a sample introduction channel 51, a sample introduction channel 52, and a sample rack separation mechanism 53. The sample rack separating mechanism 53 is configured to separate two sample racks 200 adjacent to each other on the sample channel 51 and the sample channel 52, and thereby avoid collision between the sample rack 200 that may reciprocate in the first horizontal direction on the sample channel 52 and the sample rack 200 located on the sample channel 51.

In one embodiment, the sample channel 51 and the sample channel 52 are in communication with each other, and the sample rack 200 on the sample channel 51 moves in the first horizontal direction, and the sample rack 200 on the sample channel 52 also moves in the first horizontal direction.

In another embodiment, the sample channel 51 and the sample channel 52 are in communication, the sample rack 200 on the sample channel 51 moves along the second horizontal direction, and the sample rack 200 on the sample channel 52 moves along the first horizontal direction.

Further, the sample introduction channel 51 includes a first sample rack inlet end 512 and a first sample rack outlet end 513. The sampling channel 52 includes a second sample rack inlet 521 and a second sample rack outlet 522. The first sample rack output 513 communicates with the second sample rack input 521.

In the second horizontal direction, the first sample rack output 513 is closer to the incubation unit 20 than the first sample rack input 512, thereby facilitating loading of the sample rack 200 onto the sample channel 51 by an operator from the first sample rack input 512.

The sample delivery unit 50 further includes a sample feeding driving mechanism, a sample feeding support plate 56, and a sample feeding support plate 57. The sample injection support plate 56 is configured to form the sample injection channel 51, and the sample injection support plate 57 is configured to form the sample injection channel 52. The sample feeding driving mechanism is used for driving a plurality of sample racks 200 to synchronously move towards the first sample output end along the second horizontal direction on the sample feeding channel 51 until the sample rack 200 at the forefront moves onto the sample feeding channel 52.

In one embodiment, the sample delivery unit 50 further includes a third mounting plate 48. The sample injection driving mechanism comprises a sample injection driving device 541, a third horizontal sliding rail 542, a third horizontal sliding seat 543, a sample injection pushing plate 544 and a sample injection pushing piece 545. The third horizontal sliding rail 542 and the sample injection driving device 541 are respectively disposed on the third mounting plate 48, the third horizontal sliding rail 542 is disposed along the second horizontal direction, the third horizontal sliding seat 543 is slidably connected to the third horizontal sliding rail 542, the sample injection pushing plate 544 is disposed on the third horizontal sliding seat 543 and can move synchronously with the third horizontal sliding seat 543, and the sample injection pushing member 545 is mounted on the sample injection pushing plate 544.

The output end of the sample feeding driving device 541 is connected to the third horizontal sliding seat 543, and the third horizontal sliding seat 543 moves along the second horizontal direction on the third horizontal sliding rail 542 under the driving of the sample feeding driving device 541, so as to convey the plurality of sample racks 200 onto the sampling track one by one.

In one embodiment, the third mounting plate 48 and the sample injection driving mechanism are disposed below the sample injection support plate 56, respectively. Along the second horizontal direction, two ends of the sample pushing plate 544 are respectively provided with a sample pushing member 545, the sample pushing member 545 includes sample pushing portions 5451, and the two sample pushing portions 5451 are respectively located in the sample channel 51 and are used for contacting with the sample rack 200 located on the sample channel 51, so that the sample rack 200 on the sample channel 51 is pushed toward the first sample rack output end 513 by the driving of the sample driving device 541.

Further, in a more specific embodiment, the output end of the sample feeding driving device 541 is provided with a third driving gear 546, and along the second horizontal direction, the third mounting plate 48 is further provided with a third driven gear 547 near the first sample frame output end 513. A driving belt 548 is sleeved between the third driving gear 546 and the third driven gear 547, and the third horizontal sliding seat 543 is connected to the driving belt 548. The sampling support plate 57 includes a limiting stopper 571, and the limiting stopper 571 is used for limiting the sample rack 200 that reciprocates on the sampling channel 52, so as to prevent the sample rack 200 from falling.

The limit stop 571 is provided with a sample container 210 detection sensor 572, and the sample container 210 detection sensor 572 is configured to detect the sample container 210 carried on the sample rack 200 moving on the sampling channel 52, so as to determine whether the sample container 210 is present on the sample rack 200.

In one embodiment, the sample delivery unit 50 further includes a fourth mounting plate 58. The sampling driving mechanism comprises a sampling driving device 551, a fourth horizontal sliding rail, a fourth horizontal sliding seat 553 and a sample rack clamping piece 554. The fourth horizontal sliding rail is mounted on the fourth mounting plate 58 along the first horizontal direction, the fourth horizontal sliding seat 553 is slidably connected to the fourth horizontal sliding rail, the sample rack clamping piece 554 is disposed on the fourth horizontal sliding seat 553, the sample driving device 551 is mounted on the fourth mounting plate 58, and can drive the sample rack clamping piece 554 to drive the sample rack 200 carried by the sample rack clamping piece 554 to move on the sample channel 52 along the first horizontal direction, so that the sample adding device 60 can take samples contained in the sample containers 210 carried by the sample rack 200.

Further, the sample transfer unit 50 further includes a fifth mounting plate 591, a recovery support plate 592, and a recovery drive mechanism. The recovery support plate 592 is configured with a recovery channel 594 formed thereon, the recovery channel 594 being in communication with the second sample rack output 522 for movement of the sample rack 200 after sampling is completed to facilitate recovery of the sample rack 200. The recovery driving mechanism is provided on the fifth mounting plate 591 and is located below the recovery support plate 592.

Further, the recycling driving mechanism includes a recycling driving device 5931, a fifth horizontal sliding rail, a fifth horizontal sliding seat, a recycling pushing plate 5934, and a recycling hooking member 5935. The fifth horizontal sliding rail is disposed on the fifth mounting plate 591 along the second horizontal direction, the fifth horizontal sliding seat is slidably disposed on the fifth horizontal sliding rail, the recovery pushing plate 5934 is mounted on the fifth horizontal sliding seat and can move synchronously with the fifth horizontal sliding seat, and the recovery hooking member 5935 is mounted on the recovery pushing plate 5934, and is used for hooking the sampled sample rack 200 from the second sample rack output end 522 and transferring along the recovery channel 594 under the drive of the recovery driving mechanism.

Further, the recovery hook 5935 has a hook position and a back-out position. The recovery support plate 592 is engaged with the sampling support plate 57, and is configured with a hooking member moving passage 5921 corresponding to the recovery hooking member 5935 in the second horizontal direction. When the recovery hook 5935 is in the hook position, the recovery hook 5935 at least partially passes through the hook movement channel 5921 and is positioned within the recovery channel 594. At this time, the recovery hooking member 5935 may hook the sample rack 200 at the second sample rack output end 522, and transfer the sample rack 200 onto the recovery passage 594 under the driving of the recovery driving device 5931. When the recovery hooking is to be at the avoidance position, the recovery hooking member 5935 does not extend out of the hooking member movement channel 5921.

In one embodiment, two hooking member moving channels 5921 are formed between the recovery support plate 592 and the sampling support plate 57, and one recovery hooking member 5935 is disposed on the recovery pushing plate 5934 corresponding to each hooking member moving channel 5921.

The sample rack separating mechanism 53 includes a separation driving device 531, a push plate 532, a hook 533, and a reset 534. The push plate 532 is disposed at an output end of the separation driving device 531, and the hooking member 533 is rotatably disposed on the push plate 532 and has a hooking position and a retracted position.

The sample introduction channel 51 is provided with a relief hole 511 corresponding to the hook 533, and when the hook 533 is at the hooking position, at least a portion of the hook 533 may extend out of the relief hole 511 and be located in the sample introduction channel 51. At this time, the hooking member 533 may hook the bottom of the sample rack 200 located in the sample introduction channel 51, and under the driving of the separation driving device 531, the hooking member 533 moves along with the push plate 532 synchronously toward the direction approaching the first sample rack entrance end 512, so as to separate the hooked sample rack 200 from another sample rack 200 conveyed to the adjacent sample introduction channel 52 by a certain distance.

When the hook 533 is in the retracted position, the hook 533 is rotated by a certain angle and is retracted below the sample channel 51, so that the sample driving mechanism drives the sample rack 200 to move toward the second sample rack inlet 521. Further, the reset member 534 is configured to drive the hooking member 533 to rotate from the retracted position to the hooking position.

In one embodiment, two relief holes 511 are formed on the sample-feeding support plate 56. The push plate 532 includes a first sub-board 5321 and two second sub-boards 5322, the first sub-board 5321 is connected to the output end of the separation driving device 531, and the two second sub-boards 5322 are disposed at two ends of the first sub-board 5321 along the first horizontal direction.

Further, each of the second sub-boards 5322 is provided with a hook 533 and a reset 534. One of the hooks 533 is disposed corresponding to one of the relief holes 511. When the hooking members 533 are at the hooking positions, the two hooking members 533 respectively extend out of the corresponding abdication holes 511 at least partially, and are respectively located in the sample injection channel 51 at least partially, so as to hook the sample rack 200 adjacent to the sample rack 200 on the sample injection channel 51 and the sample rack 52.

In one embodiment, the second daughter board 5322 is provided with a limiting element 5323 for limiting the hook 533. When the hooking member 533 is at the hooking position, the limiting member 5323 limits the hooking member 533 so that the hooking member is kept at the hooking position under the action of the resetting member 534.

In one embodiment, the return member 534 is a resilient return member. The second daughter board 5322 has a first connection portion 53221, the hook 533 has a second connection portion 5331, and the elastic restoring member is connected between the first connection portion 53221 and the second connection portion 5331. Further, when the hooking member 533 is at the hooking position, the elastic restoring member applies a force to the hooking member 533 so that the hooking member 533 at least partially extends out of the sample injection channel 51 and abuts against the positioning member. When the hook 533 is at the retracted position, the hook 533 is gradually retracted below the sample feeding support plate 56 under the limit of the sample feeding support plate 56, and the elastic restoring member is gradually stretched or compressed.

In another embodiment, the restoring member may be a gravity restoring member, and the gravity restoring member may drive the hooking member 533 to move to the hooking position by gravity thereof, and may be maintained in the hooking position by the limiting member 5323. Wherein, the gravity resetting piece and the hook 533 can be in an integrated structure; alternatively, the gravity restoring piece may be movably connected, such as hinged, locked, etc., to the hook 533.

By providing the reset member 534, the hooking member 533 can be driven to switch between the hooking position and the retracted position by the separation driving device 531. Thereby skillfully utilizing the separation driving device 531 to match with the elastic reset piece 534 to realize the position state switching of the hook 533, and thus, a power driving device special for driving the hook 533 to switch between the hooking position and the retreating position is not required to be arranged.

Further, an optocoupler baffle 53211 is further disposed on the first daughter board 5321, a slot-shaped optocoupler 5311 adapted to the optocoupler baffle 53211 is further disposed on the separation driving device 531, and the slot-shaped optocoupler 5311 and the optocoupler baffle 53211 are used for detecting the movement formation of the hook 533 in the hooking position under the driving of the separation driving device 531. When the slot-type optocoupler 5311 detects the optocoupler baffle 53211, the separation driving device 531 stops driving the push plate 532 to move, and at this time, the hook 533 separates the target sample rack 200 from the sample rack 200 adjacent to the sampling track by a preset distance.

The movement of the sample rack 200 on the sample transport unit 50 is as follows:

First, a plurality of sample holders 200 are placed on the sample introduction path 51; then, the sample introduction driving device 541 drives the plurality of sample holders 200 toward the sampling rail until one of the sample holders 200 located at the forefront moves to the second sample holder entry end 521 of the sampling passage 52; then, the sample rack separating mechanism 53 separates the sample rack 200 on the sample channel 51 from the sample rack 200 on the sample channel 52, and at the same time, the sample rack clamping piece 554 clamps the separated sample rack 200 on the second sample rack inlet end 521; then, the sampling driving mechanism drives the sample rack 200 to move on the sampling channel 52 and sample is carried out by the sample adding device 60; after sampling all the sample containers 210 carried by the sample rack 200, the sample rack 200 is driven by the sampling driving mechanism to move to the second sample rack output end 522; the recovery drive mechanism then drives the transfer of the sample rack 200 from the second sample rack output 522 onto the recovery channel 594.

Referring to fig. 10-11, further, after the sample is collected from the sample container 210 carried by the sample rack 200 on the sampling channel 52 by the sample application device 60, the sample application device 60 is movable in a second horizontal direction and applies the collected sample to the reagent card 100 at the sample application position.

Further, the sample loading device 60 comprises a drawing drive device 61, a screw 62, a nut 63 and a plunger 64. One end of the screw rod 62 is connected with the drawing and discharging driving device 61, the nut 63 is sleeved on the screw rod 62, the plunger 64 comprises a plunger rod 641 and a plunger body 642, and one end of the plunger rod 641 extending out of the plunger body 642 is connected with the nut 63.

The drawing drive device 61 drives the screw rod 62 to rotate forward so as to enable the nut 63 to move towards the direction approaching to the drawing drive device 61, and the nut 63 moves to drive the piston rod 641 to synchronously move so that the plunger 64 can draw the sample in the sample container 210. The drawing and discharging driving device 61 drives the screw rod 62 to reversely rotate so as to enable the nut 63 to move towards the direction away from the drawing and discharging driving device 61, and the nut 63 moves to drive the piston rod 641 to synchronously move so that the plunger 64 can spit and pour the sucked sample.

By extending the stopper 641 out of the first end of the stopper body 642 to be directly connected with the nut 63, the integral structure of the seat of the nut 63 can be in threaded connection with the screw rod 62 and also can be fixedly connected with the stopper 641, thereby avoiding the arrangement of a special transmission block to mount the nut 63 and connect the stopper 641, effectively compressing the overall size of the sample adding device 60, improving the space utilization rate thereof, simplifying the assembly step of the sample adding device 60, improving the assembly efficiency and reasonably controlling the production cost.

Further, the sample loading device 60 includes a housing 65, an installation cavity 651 is formed in the housing 65, the screw rod 62 and the nut 63 are disposed in the installation cavity 651, the plunger 64 is at least partially disposed in the installation cavity 651, the drawing and discharging driving device 61 is mounted outside the housing 65, and an output end of the drawing and discharging driving device 61 passes through the housing 65 and is connected with the screw rod 62.

Further, the sample loading device 60 further includes a guide rod 66, the guide rod 66 is parallel to the screw rod 62, wherein the nut 63 is provided with a guide hole 631 adapted to the guide rod 66, the guide rod 66 passes through the guide hole 631, and two ends of the guide rod 66 are fixed in the installation cavity 651.

In one embodiment, the screw rod 62 is located between the rod 641 and the guide rod 66, so that when the drawing and discharging driving device 61 drives the screw rod 62 to rotate, the acting forces of the guide rod 66 and the rod 641 on the screw rod 62 are balanced through the nut 63, so that the drawing and discharging driving device 61 drives the screw rod 62 to drive the nut 63 to move to suck and discharge a sample. By arranging the guide rod 66 to be matched with the guide hole 631 on the nut 63, the drawing and placing driving device 61 can drive the screw rod 62 to rotate so as to drive the nut 63 and the stopper rod 641 to move for drawing and placing, and the sample sucking and discharging efficiency is improved.

In one embodiment, the pipette tip 6421 of the plug 642 is loaded with a pipette tip for sample transfer. Since the pipetting head is a disposable consumable 310, it is also necessary to unload and reload the current pipetting head with a new one after each sample transfer. Further, the sample loading device 60 further comprises a push post 671, a push post reset 672 and an unloading push 673. The pushing post 671 is disposed on the housing 65 in a penetrating manner, a first end of the pushing post 671 is disposed in the mounting cavity 651, a second end of the pushing post 671 is connected to the unloading pushing member 673, and the unloading pushing member 673 is sleeved outside the plug body 642 and can move synchronously with the pushing post 671 to unload the pipetting head loaded at the suction head 6421.

Further, the push post 671 has a loading position and an unloading position. The push post resetting piece 672 is sleeved on the push post 671 and is used for driving the push post 671 to reset to the loading position. When the pipetting head needs to be unloaded, the drawing and discharging driving device 61 drives the screw rod 62 to rotate to drive the nut 63 to move towards the first end of the pushing post 671 until the nut 63 pushes the pushing post 671 to move synchronously with the unloading pushing piece 673 until the pipetting head is unloaded. During this process, the push post reset member 672 is gradually compressed. After the unloading of the target pipetting head is completed, the drawing and discharging driving device 61 drives the screw rod 62 to reversely rotate to drive the nut 63 to move towards the direction approaching to the drawing and discharging driving device 61, and in the process, the pushing post resetting piece 672 gradually drives the pushing post 671 to drive the unloading pushing piece 673 to reset.

Further, the pushing post 671 is further connected with a unloading sensing piece 6711, and an adaptive unloading sensor 652 is disposed in the mounting cavity 651 corresponding to the unloading sensing piece 6711. When the target pipetting head is unloaded, the unloading sensing tab 6711 is separated from the unloading sensor 652. When the pipette head is reloaded with a new one, the unloading sensing tab 6711 moves into the detection area of the unloading sensor 652 along with the push post 671.

Further, the nut 63 is provided with a pipetting sensor 632, and the mounting cavity 651 is further provided with a pipetting sensor 653. The pipetting sensor 653 corresponds to the pipetting sensor 653, and when the rod 641 is moved with the nut 63 in a direction towards the pipetting drive 61 for pipetting, the pipetting sensor 632 will leave the pipetting sensor 653. When the stopper 641 moves away from the drawing drive device 61 along with the nut 63 until the liquid discharge is completed, the liquid discharge sensing portion 632 is sensed again by the liquid discharge sensor 653.

Further, the sample loading device 60 further comprises a pressure sensor 654, and the pressure sensor 654 is in communication with the interior of the suction head 6421 via a pipeline, and is used for detecting the pressure inside the suction head 6421. When the air pressure sensor 654 detects that the pressure inside the suction head 6421 reaches the requirement of pipetting, the pipetting drive device 61 drives the screw 62 to rotate to drive the nut 63 to move towards the direction approaching to the pipetting drive device 61, so that the stopper 641 moves synchronously to enable the pipetting head to aspirate samples from the sample container 210.

Further, the loading device 60 further comprises a third horizontal driving set 68 and a second lifting driving set 69. The second lifting driving set 69 is configured to drive the pipettor to move in a vertical direction to drive the pipetting head to synchronously lift, so that the pipetting head can access the sample container 210 for sampling and move to the reagent card 100 for sample ejection. The third horizontal driving set 68 is configured to drive the housing 65 to move along the second horizontal direction, so that the housing 65 drives the pipetting head to move along the second horizontal direction synchronously, thereby transferring the sample along the second horizontal direction.

Referring to fig. 12 in combination with fig. 1, the immunoassay analyzer further includes a consumable supply unit 70 disposed between the reagent card dispensing mechanism 40 and the sample application device 60. The consumable supply unit 70 is used to supply consumable 310 required for testing. Further, the consumable supply unit 70 carries a consumable container 300, and the consumable container 300 carries the consumable 310.

In one embodiment, the consumable supply unit 70 is movable in the first horizontal direction between a consumable 310 initial position and a consumable loading position. When the consumable supply unit 70 is at the initial position of the consumable 310, the consumable supply unit 70 is visually located on the workbench 10, so that an operator can intuitively observe and judge the consumption of the consumable 310.

Further, the consumable container 300 may be assembled and disassembled in a vertical direction. Specifically, in this embodiment, by loading and unloading the consumable container 300 in the vertical direction, the space above the consumable supply unit 70 may be fully utilized, so as to reduce the requirement of the immunoassay analyzer on the side space thereof, and further effectively reduce the occupation of the immunoassay analyzer on the side space thereof in the installation and use process. When the consumable supply unit 70 is in the consumable loading position, the loading device 60 may load the consumable 310.

Further, the consumable supply unit 70 includes a consumable 310 transfer driving set and a consumable carrier, where the consumable 310 transfer driving set is used to drive the consumable carrier to move between the consumable 310 initial position and the consumable loading position.

In one embodiment, the consumable supply unit 70 includes a first consumable storage area 71 and a second consumable storage area 72 arranged along the first horizontal direction. The consumable carrier is configured with the first consumable storage area 71 and the second consumable storage area 72. Wherein, the first consumable storage area 71 is used for storing the pipetting head, which may be a TIP head. The second consumable storage area 72 is used for storing a reaction container 400 containing a reagent, and the reaction container 400 may be a microplate.

Further, the consumable loading positions comprise a first sub-consumable loading position and a second sub-consumable loading position. When the consumable supply unit 70 is in the first sub-consumable loading position, the loading device 60 may load the pipetting head from the first sub-consumable loading position. The loading device 60 may load the sucked sample into the reaction container 400 when the consumable supply unit 70 is in the second sub-consumable loading position.

In another embodiment, the second consumable storage area 72 is used to store a dilution plate 600, and the dilution plate 600 is configured with a plurality of dilution sites 610, each of the dilution sites 610 being used to perform dilution of one of the samples. Further, a third consumable storage area 73 is further configured on the consumable carrier, and the third consumable storage area 73 can be used for storing a diluent container 700 containing diluent.

The consumable loading position further includes a third sub-consumable loading position, and when the consumable supply unit 70 is in the third sub-consumable loading position, the sample loading device 60 may draw the diluent from the diluent container 700 at the third sub-consumable loading position, and fill the diluent into the dilution position 610, and fill the sample to be diluted into the dilution position 610.

Further, the sample adding device 60 also has a function of sucking, discharging and mixing. So as to facilitate the mixed solution of the sample and the diluent to be sucked and spitted for a plurality of times, thereby realizing the uniform mixing of the mixed solution. Further, for the detection item that needs to fill the sample into the microwell plate for the first incubation of the sample and the reagent, the sample filling device 60 controls the plunger 64 to perform multiple times of sucking and spitting on the sample and the reagent in the microwell after filling the sample into the microwell of the microwell plate, so as to realize the mixing treatment of the sample and the reagent.

Further, the working procedure of the loading device 60 and the consumable supply unit 70 are as follows;

Firstly, the consumable 310 working unit moves to the first sub-consumable loading position; then, the sample adding device 60 moves to the first sub-consumable loading position and loads one pipetting head; the loading device 60 is then moved over the sampling channel 52; then, the second elevation drive set 69 drives the pipetting head down and into a target reagent container; then, the pumping and discharging driving device 61 drives the plunger 64 to match the pipetting head to suck samples; after sampling is completed, the second lifting driving group 69 drives the pipetting head to leave the target reagent container again; then, the third horizontal driving group 68 drives the shell 65 to move so as to drive the pipetting head to move, thereby transferring the sucked sample to the second sub-consumable loading position; then, the drawing drive device 61 drives the plunger 64 to fill the sucked sample into one of the microwells of the microwell plate; then, the pumping and discharging driving device 61 drives the plunger device 64 to pump, discharge, suck and discharge the sample and the reagent in the micropores uniformly; after the drawing, discharging, sucking and spitting are completed, the third horizontal driving set 68 drives the shell 65 to move again to drive the pipetting head to move to the consumable 310 discarding position; then, the drawing and discharging driving device 61 drives the nut 63 to push the pushing post 671, so that the unloading pushing piece 673 is driven by the pushing post 671 to synchronously move to push the pipetting head away from the suction head 6421, and the unloading of the pipetting head is completed.

In some embodiments, after the first incubation of the mixture of the sample and the reagent on the microplate is completed, the pumping and discharging driving device 61 drives the plunger device 64 again to cooperate with the pipetting head to pump the mixture, and transfer the mixture to one of the reagent cards 100; the reagent card dispatching mechanism 40 then transfers the reagent card 100 to one of the incubation compartments 21 for a second incubation.

Further, the first horizontal direction and the second horizontal direction are two different directions. In a more specific embodiment, the first horizontal direction and the second horizontal direction are two mutually perpendicular directions. Therefore, in the present application, the plurality of incubation bins 21 are arranged along the first horizontal direction, the plurality of reagent cartridge bins 31 are arranged on the incubation unit 20 along the first horizontal direction, the consumable supply unit 70 is moved along the first horizontal direction, the sample rack 200 is transported along the first horizontal direction, and the sample loading device 60 is transferred along the second horizontal direction, so that each functional unit of the immunoassay analyzer is transferred along each straight line path, and irregular layout of each functional unit caused by a complicated and complicated movement path is avoided, thereby effectively improving the space utilization rate of the immunoassay analyzer.

In addition, in the present application, the reagent cartridge 90 is loaded and unloaded in the vertical direction, and the consumable container 300 is loaded and unloaded in the vertical direction, so that the space above the workbench 10 is fully utilized, and the occupation of the side space of the immunoassay analyzer is avoided. In the application, when the amplification is needed, at least two incubation units 20 are stacked, and at least one detection unit 80 and at least one reagent cartridge storage unit 30 are arranged on the incubation units 20, so that the space above the workbench 10 can be further fully utilized to realize the amplification, and the occupation of the side space of the immunoassay analyzer is avoided.

Spatially relative terms, such as "above … …," "above … …," "upper surface on … …," "above," and the like, may be used herein for ease of description to describe one device or feature's spatial location relative to another device or feature as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as "above" or "over" other devices or structures would then be oriented "below" or "beneath" the other devices or structures. Thus, the exemplary term "above … …" may include both orientations "above … …" and "below … …". The device may also be positioned in other different ways (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.

In addition, the terms "first", "second", etc. are used to define the components, and are only for convenience of distinguishing the corresponding components, and the terms have no special meaning unless otherwise stated, and therefore should not be construed as limiting the scope of the present application. The above is only a preferred embodiment of the present application, and is not intended to limit the present application, but various modifications and variations can be made to the present application by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application should be included in the protection scope of the present application.

Claims (10)

1. A pipette, comprising:

a housing (65), the housing (65) being configured with a mounting cavity (651);

The drawing and discharging driving module comprises a drawing and discharging driving device (61), a screw rod (62) and a nut (63), wherein the drawing and discharging driving device (61) is arranged on the shell (65), the screw rod (62) is arranged in the mounting cavity (651), one end of the screw rod (62) is connected with the output end of the drawing and discharging driving device (61), and the nut (63) is sleeved on the screw rod (62) and is in threaded connection with the screw rod (62);

plunger (64), plunger (64) include stopper rod (641) and cock body (642), cock body (642) are connected on casing (65), stopper rod (641) stretches out the one end of cock body (642) is connected with nut (63).

2. The pipette according to claim 1, further comprising a guide rod (66), wherein the nut (63) is provided with a guide hole (631) matched with the guide rod (66), the guide rod (66) is fixed in the mounting cavity (651) through the guide hole (631), and the guide rod (66) and the screw rod (62) are mutually parallel.

3. A pipette according to claim 2, wherein the screw (62) is located between the stopper rod (641) and the guide rod (66).

4. A pipette as recited in any one of claims 1-3, wherein a pipette tip is provided at a pipette tip (6421) of the plug body (642) during pipetting;

The pipette further comprises a pushing post (671), a pushing post reset piece (672) and an unloading pushing piece (673), wherein the pushing post (671) is arranged on the shell (65) in a penetrating mode, a first end of the pushing post (671) is located in the installation cavity (651), a second end of the pushing post (671) is connected with the unloading pushing piece (673), and the unloading pushing piece (673) is sleeved on the outer side of the plug body (642) and can move synchronously along with the pushing post (671) to unload the pipette head arranged at the suction head (6421).

5. The pipette of claim 4, wherein a first end of the push post (671) corresponds to the nut (63), the push post (671) having a loading position and an unloading position;

The push post reset piece (672) is sleeved on the push post (671) and is used for driving the push post (671) to reset from the unloading position to the loading position.

6. The pipette of claim 5, wherein the extraction drive (61) drives the screw (62) to rotate to move the nut (63) toward the first end of the push post (671) and to push the push post (671) from the loading position to the unloading position.

7. The pipette according to claim 4, wherein an unloading sensing piece (6711) is arranged on the pushing post (671), an unloading sensor (652) which is matched with the unloading sensing piece (6711) is arranged in the mounting cavity (651), and the pipette is loaded at the suction head (6421) of the plug body (642) when the unloading sensing piece (6711) is detected by the unloading sensor (652) in the process of loading the pipette.

8. The pipette according to claim 4, wherein the nut (63) comprises a pipetting induction part (632), a pipetting sensor (653) adapted to the pipetting induction part (632) is arranged in the mounting cavity (651), and the plunger (64) opens the pipette when the nut (63) moves towards the pipetting drive device (61) until the pipetting sensor (653) cannot detect the pipetting induction part (632).

9. A loading device comprising a pipette as defined in any one of claims 1 to 8.

10. An immunoassay analyzer comprising the sample application device of claim 9.