CN118141700A - Oil-controlling and anti-inflammatory composition and preparation method and application thereof - Google Patents

Abstract

The present invention relates to the field of cosmetics, and more particularly to a kind of oil-controlling and anti-inflammatory composition and its preparation method and application. The oil-controlling and anti-inflammatory composition of the present invention comprises the following components in parts by weight: 0.1-2 parts of capryloyl glycine, 0.1-1 parts of sea silt, 0.1-5 parts of grape (VITIS VINIFERA) flower extract, 0.1-5 parts of myrtle (RHODOMYRTUS TOMENTOSA) fruit extract, 0.1-5 parts of Antarctic stalk algae (DURVILLEA ANTARTICA) extract, 0.1-5 parts of redwood (BIXA ORELLANA) seed extract, and 1-35 parts of yeast/barley seed fermentation product filtrate. The oil-controlling and anti-inflammatory composition of the present invention solves the problem of oil-controlling and anti-inflammatory from multiple dimensions, is particularly suitable for oil-controlling care of human face, and the oil-controlling and anti-inflammatory composition is added to cosmetics to achieve safe and efficient oil-controlling and anti-inflammatory effects.

Description

Oil-controlling and anti-inflammatory composition and preparation method and application thereof

Technical Field

The present invention relates to the field of cosmetics, and in particular to an oil-controlling and anti-inflammatory composition and a preparation method and application thereof.

Background technique

Excessive facial oil secretion is basically seborrhea. The main cause of seborrhea is the overactive sebaceous glands on the face, which may lead to a large amount of sebum secretion. Areas with large pores will more easily secrete excess oil, which may cause symptoms of excessive facial oiliness. The main reason for the overactive sebaceous glands is the stimulation of dihydrotestosterone, which happens to be a component of male hormones. The formation of these male hormones is caused by genetic factors, and it may also be due to the lack of sleep due to staying up late, and often eating spicy and irritating foods, which will lead to excessive secretion of male hormones, especially the secretion of dihydrotestosterone, which will stimulate the sebaceous glands to form too much sebum. Excessive sebum secretion will then cause more skin diseases, which are common in the formation of open comedones, which further deteriorate to form inflammatory acne, and then accompanied by immune response. Acne will gradually deteriorate and cause chronic inflammation and exist for a long time.

Existing oil-control cosmetics have unsatisfactory oil-control effects and a high risk of allergy. The oil-control and anti-acne ingredients on the market are often acidic in pH. Although they are effective, they have high requirements for the compatibility of cosmetic dosage forms. If it is an emulsified system oil-control product, not only will it fail to achieve the oil-control effect, but it may also greatly increase the oil content of the skin due to improper oil matching, further worsening the formation of acne and inflammatory acne; or if the oil-absorbing powder is used improperly, the face will have local floating powder that affects the appearance, and may also clog the pores, destroy the water-oil balance of the skin, and then cause more skin diseases; and most of the plastic microparticles on the market are used as oil-absorbing powders. Such plastic microparticles are not biodegradable, and if they are not used in a controlled manner, they will seriously damage the environment. At present, some countries have banned their production.

In today's fast-paced society, more and more people stay up late and lack sleep, and often eat spicy and irritating foods, which causes the sebaceous glands to secrete a large amount of sebum. This makes it even more difficult to control oil secretion through diet and daily routine. Using cosmetics to solve this skin problem is more efficient and more tolerant.

Therefore, people have a strong demand for developing a cosmetic product that can reduce facial oil secretion, efficiently absorb facial oil, and control skin oil for a long time.

Summary of the invention

The purpose of the present invention is to overcome the shortcomings of the prior art and provide an oil-controlling and anti-inflammatory composition, which solves the oil-controlling and anti-inflammatory problems from multiple dimensions and is particularly suitable for oil-controlling care of the human face. The oil-controlling and anti-inflammatory composition is added to cosmetics to achieve safe and efficient oil-controlling and anti-inflammatory effects.

To achieve the above object, the technical solution adopted by the present invention is:

In a first aspect, the present invention provides an oil-controlling and anti-inflammatory composition, comprising the following components in parts by weight: 0.1-2 parts of capryloyl glycine, 0.1-1 parts of sea silt, 0.1-5 parts of grape (VITIS VINIFERA) flower extract, 0.1-5 parts of myrtle (RHODOMYRTUS TOMENTOSA) fruit extract, 0.1-5 parts of Antarctic thorn algae (DURVILLEA ANTARTICA) extract, 0.1-5 parts of redwood (BIXA ORELLANA) seed extract, and 1-35 parts of yeast/barley seed fermentation product filtrate.

The capryloyl glycine used in the present invention can provide free carboxyl groups, maintain the balance of the pH value of the skin, regulate the oil secretion of the skin, and rebuild the normal epidermal sebum membrane; the sea silt is an oil-absorbing powder, rich in minerals, environmentally friendly, and has excellent adsorption and oil absorption capabilities. It can also be used as a carrier of active substances to protect the active substances from being affected by light. When applied, the active substances and the excessive oil secreted by the skin can be replaced, thereby achieving a safe and efficient oil control effect; the grape (VITIS VINIFERA) flower extract promotes tissue reconstruction and inhibits the inflammatory cascade reaction, has a certain astringent effect, and refines pores and reduces oil production; the myrtle (RHODOMYRTUS TOMENTOSA) fruit extract is rich in acyl chloroglucitol, polyphenols (stilbene) and organic acids, and can effectively regulate the lipid production caused by changes in sebaceous cell hormones; the Antarctic stalk algae (DURVILLEA ANTARTICA) extract contains glycine betaine as a penetration resistance, which can protect the skin's sebum membrane in an unstable and stressful environment and maintain normal skin secretion; the redwood (BIXA ORELLANA) seed extract can reduce the number of active hair follicles, reduce COX-2 gene expression, 5α reductase activity, control oil output from the source, and thus reduce the formation of lipid droplets in sebaceous glands; the yeast/barley seed fermentation product filtrate is weakly acidic and can inhibit harmful bacteria on the skin. Because many harmful bacteria on the skin are more likely to survive in an alkaline environment, maintaining an acidic environment maintains a more monitored skin microecological environment and reduces oil production. The oil-control and anti-inflammatory composition of the present invention selects the above-mentioned specific components and controls them in a specific weight ratio, and solves the oil-control and anti-inflammatory problems from multiple dimensions, including basic hydration and moisturizing, inhibiting sebum oxidation, regulating sebum cell proliferation, improving enlarged pores, reducing excessive oil accumulation, optimizing sebum quality, and reducing inflammation. The interaction of the components enhances the overall oil-control and anti-inflammatory effect, and is particularly suitable for oil-control care of the human face.

Preferably, the oil-control and anti-inflammatory composition comprises the following components in parts by weight: 1 part of capryloyl glycine, 0.5 parts of sea silt, 3 parts of grape (VITIS VINIFERA) flower extract, 3 parts of myrtle (RHODOMYRTUS TOMENTOSA) fruit extract, 3 parts of Antarctic thorn algae (DURVILLEA ANTARTICA) extract, 3 parts of redwood (BIXA ORELLANA) seed extract, and 20 parts of yeast/barley seed fermentation product filtrate.

The oil-control and anti-inflammatory composition of the present invention has the strongest interaction effect among the components under the above-mentioned specific weight ratio, can reduce excessive oil accumulation, optimize sebum quality, and improve the overall skin condition with the best effect. At the same time, it has a more obvious anti-inflammatory effect and improves the overall skin condition with the best effect.

In a second aspect, the present invention provides use of the above-mentioned oil-controlling and anti-inflammatory composition in the preparation of cosmetics.

Preferably, the cosmetic is lotion.

In a third aspect, the present invention provides an oil-controlling and anti-inflammatory lotion, comprising the above-mentioned oil-controlling and anti-inflammatory composition; the weight percentage of the oil-controlling and anti-inflammatory composition in the oil-controlling and anti-inflammatory lotion is 1.6%-58%.

The oil-controlling and anti-inflammatory composition of the present invention is added into lotion to protect the active substances in the system and exert safe and efficient oil-controlling and anti-inflammatory effects.

Preferably, the oil-controlling and anti-inflammatory lotion further comprises an adsorbent, a chelating agent, a moisturizer, a pH regulator, an antioxidant and water.

Preferably, the oil-controlling and anti-inflammatory lotion comprises the following components in weight percentage: 1.6%-58% of the oil-controlling and anti-inflammatory composition, 0.1%-0.5% of the adsorbent, 0.03%-0.06% of the chelating agent, 6.51%-18.05% of the moisturizing agent, 0.1%-2% of the pH adjusting agent, 0.4%-0.6% of the antioxidant, and the remainder of water.

The components of the oil-controlling and anti-inflammatory lotion prepared by the present invention have a refreshing and comfortable skin feel under the above-mentioned ratio, and are suitable for people with oily skin. Under this ratio, the powder layer of the lotion can be controlled to reach a specific height after standing, thereby optimizing the oil control ability of the powder layer and allowing the powder layer to be easily and evenly dispersed in the water layer for application.

Preferably, the adsorbent is hectorite; the chelating agent is disodium EDTA; the moisturizing agent includes at least one of butanediol, 1,2-hexanediol, allantoin, β-glucan, and glycerol; the pH regulator is arginine; and the antioxidant is p-hydroxyacetophenone.

The hectorite used in the present invention is natural clay with excellent hydrophilicity. It can absorb water when dispersed in the system to form a honeycomb network and has good suspension ability. The clay particles are negatively charged and can balance the attraction and repulsion between charges when dispersed in water with silica. The weak bonds allow thixotropic flow, so the powder layer will not stick to the bottom of the bottle even if it settles for a long time. When in use, the powder layer can be evenly dispersed in the system by simply shaking and applying external force, giving an excellent user experience.

In a fourth aspect, the present invention provides a method for preparing the above-mentioned oil-controlling and anti-inflammatory lotion, comprising the following steps:

(1) mixing an adsorbent and 21%-79% of water, heating, homogenizing and stirring, then adding a chelating agent, 0.1%-1% of an oil-controlling and anti-inflammatory composition, and 1.1%-10.4% of a moisturizer, mixing evenly, stirring, and cooling to obtain a mixture A;

(2) mixing an antioxidant and 5.4% to 7.6% of a moisturizer, heating to dissolve, adding the mixture to the mixture A obtained in step (1), stirring, and cooling to obtain a mixture B;

(3) 0.1%-2% of the oil-controlling and anti-inflammatory composition, the pH regulator and the remaining water are mixed, heated to dissolve, added to the mixture B obtained in step (2), stirred, and the remaining oil-controlling and anti-inflammatory composition and the remaining moisturizer are added and mixed evenly, stirred, homogenized and cooled to obtain the oil-controlling and anti-inflammatory lotion.

The oil-controlling and anti-inflammatory composition provided by the present invention is dispersed in a dispersion liquid with hectorite and sea silt as the matrix, and the dosage form is designed as a water-powder layer, and the main additive of the powder layer is sea silt. When using the cosmetics prepared by the present invention, the powder layer can be evenly dispersed in the water phase by simply shaking, so that it is convenient and evenly applied to the skin.

Preferably, the above preparation method comprises at least one of the following (a)-(d):

(a) In step (1), the heating temperature is 80-85°C; the homogenization speed is 3000 rpm; and the cooling is to 60°C;

(b) In the step (2), the heating temperature is 60°C; the cooling is to 45°C;

(c) In the step (3), the heating temperature is 80°C; the homogenization condition is homogenization at a speed of 3000 rpm for 2 min; and the cooling is cooling to 38°C;

(d) In steps (1), (2) and (3), the stirring speed is 15-20 rpm.

The beneficial effects of the present invention are:

1. The oil-control and anti-inflammatory composition of the present invention selects specific components to solve the oil-control and anti-inflammatory problems from multiple dimensions, including basic moisturizing, inhibiting sebum oxidation, regulating sebum cell proliferation, improving enlarged pores, reducing excessive oil accumulation, optimizing sebum quality, and reducing inflammation. The interaction of each component enhances the overall oil-control and anti-inflammatory effect, and is particularly suitable for oil-control care of the human face;

2. The hectorite and sea silt used in the present invention form a powder-water system in a specific proportion: the appearance is a clear and transparent upper layer and a fluffy powder layer at the lower layer. After the sea silt absorbs substances in the system, the density of the powder layer increases and settles, and a fixed layer height can be reached after 24 hours, which ensures the aesthetic design of the product's appearance and also has a refreshing and comfortable skin feel. At the same time, after the powder layer has settled for a long time, it can be evenly dispersed in the system by simply shaking it with a little external force; in this powder-water system, the oil-controlling and anti-inflammatory composition can be protected by the silica carrier, and does not affect the stability and feel of the lotion, thereby more efficiently exerting the oil-controlling and anti-inflammatory effects;

3. The present invention starts from the manifestation of excessive facial oil secretion, inhibits androgen to control 5α-reductase to convert androgen, slows down excessive sebum secretion; regulates the acidic barrier of the skin, promotes the accelerated differentiation of immature cells, balances the skin microecology, forms a healthy stratum corneum, prevents disordered shedding to form closed comedones, inhibits inflammation, and prevents the stratum corneum surface near the pores from peeling off, thereby better improving and preventing the condition of enlarged pores; physically absorbs excessive oil secretion, strengthens moisturizing to achieve water-oil balance of the skin, and other aspects are taken into consideration to obtain cosmetics with high efficiency and long-lasting oil control and anti-inflammatory effects.

Detailed ways

In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

The capryloylglycine and yeast/barley seed fermentation product filtrate used in the present invention were purchased from Guangzhou Baihaobo Co., Ltd.; sea silt, grape (VITIS VINIFERA) flower extract, myrtle (RHODOMYRTUS TOMENTOSA) fruit extract, Antarctic thorn algae (DURVILLEA ANTARTICA) extract, and redwood (BIXA ORELLANA) seed extract were purchased from Guangzhou Feike Trading Co., Ltd.

Embodiment 1-3:

Examples 1-3 of the present invention are the oil-controlling and anti-inflammatory compositions of the present invention. The compositions and weight portions of the oil-controlling and anti-inflammatory compositions of Examples 1-3 are shown in Table 1.

Table 1

Comparative Examples 1-15:

Comparative Examples 1-15 are comparative examples of the oil-controlling and anti-inflammatory compositions of the present invention. The compositions and weight portions of the oil-controlling and anti-inflammatory compositions of Comparative Examples 1-15 are shown in Table 2; wherein the components missing in Comparative Examples 1-7 are supplemented with an equal amount of water.

Table 2

Application Examples 1-5:

Application Examples 1-5 are the oil-controlling and anti-inflammatory lotions described in the present invention. The formulas of the oil-controlling and anti-inflammatory lotions described in Application Examples 1-5 are shown in Table 3.

table 3

The preparation method of the oil-controlling and anti-inflammatory lotion comprises the following steps:

(1) Mix hectorite and an appropriate amount of water (21%-79% to dissolve the remaining components), heat to 80-85° C., start homogenization at a homogenization speed of 3000 rpm, stir at a speed of 20 rpm for 20 min, then add sea silt, disodium EDTA, allantoin and glycerol, mix well, stir at a speed of 20 rpm, and cool to 60° C. to obtain a mixture A;

(2) mixing butanediol, p-hydroxyacetophenone and 1,2-hexanediol, heating at 60° C. to dissolve, adding the mixture to the mixture A obtained in step (1), stirring at a speed of 20 rpm, and cooling to 45° C. to obtain a mixture B;

(3) Capryloylglycine, arginine and the remaining water are mixed, heated at 80° C. to dissolve, and added to the mixture B obtained in step (2), and stirred at a speed of 20 rpm for 3 min. Saccharomyces cerevisiae/barley seed fermentation product filtrate, grape (VITISVINIFERA) flower extract, myrtle (RHODOMYRTUS TOMENTOSA) fruit extract, Antarctic stalk algae (DURVILLEA ANTARTICA) extract, redwood (BIXA ORELLANA) seed extract, and β-glucan are added and mixed evenly, and stirred at a speed of 20 rpm for 3 min, and homogenized at a speed of 3000 rpm for 2 min; stirred at a speed of 15-20 rpm, and cooled to 38° C. to obtain the oil-controlling and anti-inflammatory lotion.

Application Comparative Example 1:

An application comparative example of the oil-controlling and anti-inflammatory lotion of the present invention is different from Application Example 1 in that the oil-controlling and anti-inflammatory composition of Example 1 is replaced with the oil-controlling and anti-inflammatory composition of Comparative Example 1; the rest is the same as Application Example 1.

The preparation method of the oil-controlling and anti-inflammatory lotion described in this comparative application example is the same as that of application example 1.

Application Comparative Example 2:

An application comparative example of the oil-controlling and anti-inflammatory lotion of the present invention is different from Application Example 1 in that the oil-controlling and anti-inflammatory composition of Example 1 is replaced with the oil-controlling and anti-inflammatory composition of Comparative Example 2; the rest is the same as Application Example 1.

The preparation method of the oil-controlling and anti-inflammatory lotion described in this comparative application example is the same as that of application example 1.

Application Comparative Example 3:

An application comparative example of the oil-controlling and anti-inflammatory lotion of the present invention is different from Application Example 1 in that the oil-controlling and anti-inflammatory composition of Example 1 is replaced with the oil-controlling and anti-inflammatory composition of Comparative Example 3; the rest is the same as Application Example 1.

The preparation method of the oil-controlling and anti-inflammatory lotion described in this comparative application example is the same as that of application example 1.

Application Comparative Example 4:

An application comparative example of the oil-controlling and anti-inflammatory lotion of the present invention is different from Application Example 1 in that the oil-controlling and anti-inflammatory composition of Example 1 is replaced with the oil-controlling and anti-inflammatory composition of Comparative Example 4; the rest is the same as Application Example 1.

The preparation method of the oil-controlling and anti-inflammatory lotion described in this comparative application example is the same as that of application example 1.

Application Comparative Example 5:

An application comparative example of the oil-controlling and anti-inflammatory lotion of the present invention is different from Application Example 1 in that the oil-controlling and anti-inflammatory composition of Example 1 is replaced with the oil-controlling and anti-inflammatory composition of Comparative Example 5; the rest is the same as Application Example 1.

The preparation method of the oil-controlling and anti-inflammatory lotion described in this comparative application example is the same as that of application example 1.

Application Comparative Example 6:

An application comparative example of the oil-controlling and anti-inflammatory lotion of the present invention is different from Application Example 1 in that the oil-controlling and anti-inflammatory composition of Example 1 is replaced with the oil-controlling and anti-inflammatory composition of Comparative Example 6; the rest is the same as Application Example 1.

The preparation method of the oil-controlling and anti-inflammatory lotion described in this comparative application example is the same as that of application example 1.

Application Comparative Example 7:

An application comparative example of the oil-controlling and anti-inflammatory lotion of the present invention is different from Application Example 1 in that the oil-controlling and anti-inflammatory composition of Example 1 is replaced with the oil-controlling and anti-inflammatory composition of Comparative Example 7; the rest is the same as Application Example 1.

The preparation method of the oil-controlling and anti-inflammatory lotion described in this comparative application example is the same as that of application example 1.

Application Comparative Example 8:

An application comparative example of the oil-controlling and anti-inflammatory lotion of the present invention is different from Application Example 1 in that 33.5% of the oil-controlling and anti-inflammatory composition of Example 1 is replaced with 80% of the oil-controlling and anti-inflammatory composition of Comparative Example 8; the rest is the same as Application Example 1.

The preparation method of the oil-controlling and anti-inflammatory lotion described in this comparative application example is the same as that of application example 1.

Application Comparative Example 9:

An application comparative example of the oil-controlling and anti-inflammatory lotion of the present invention is different from Application Example 1 in that 33.5% of the oil-controlling and anti-inflammatory composition of Example 1 is replaced with 39.5% of the oil-controlling and anti-inflammatory composition of Comparative Example 9; the rest is the same as Application Example 1.

The preparation method of the oil-controlling and anti-inflammatory lotion described in this comparative application example is the same as that of application example 1.

Application Comparative Example 10:

An application comparative example of the oil-controlling and anti-inflammatory lotion of the present invention is different from Application Example 1 in that 33.5% of the oil-controlling and anti-inflammatory composition of Example 1 is replaced with 39.5% of the oil-controlling and anti-inflammatory composition of Comparative Example 10; the rest is the same as Application Example 1.

The preparation method of the oil-controlling and anti-inflammatory lotion described in this comparative application example is the same as that of application example 1.

Application Comparative Example 11:

An application comparative example of the oil-controlling and anti-inflammatory lotion of the present invention is different from Application Example 1 in that 33.5% of the oil-controlling and anti-inflammatory composition of Example 1 is replaced with 39.5% of the oil-controlling and anti-inflammatory composition of Comparative Example 11; the rest is the same as Application Example 1.

The preparation method of the oil-controlling and anti-inflammatory lotion described in this comparative application example is the same as that of application example 1.

Application Comparative Example 12:

An application comparative example of the oil-controlling and anti-inflammatory lotion of the present invention is different from Application Example 1 in that 33.5% of the oil-controlling and anti-inflammatory composition of Example 1 is replaced with 39.5% of the oil-controlling and anti-inflammatory composition of Comparative Example 12; the rest is the same as Application Example 1.

The preparation method of the oil-controlling and anti-inflammatory lotion described in this comparative application example is the same as that of application example 1.

Application Comparative Example 13:

An application comparative example of the oil-controlling and anti-inflammatory lotion of the present invention is different from Application Example 1 in that 33.5% of the oil-controlling and anti-inflammatory composition of Example 1 is replaced with 53.5% of the oil-controlling and anti-inflammatory composition of Comparative Example 13; the rest is the same as Application Example 1.

The preparation method of the oil-controlling and anti-inflammatory lotion described in this comparative application example is the same as that of application example 1.

Application Comparative Example 14:

An application comparative example of the oil-controlling and anti-inflammatory lotion of the present invention is different from Application Example 1 in that 33.5% of the oil-controlling and anti-inflammatory composition of Example 1 is replaced with 34.5% of the oil-controlling and anti-inflammatory composition of Comparative Example 14; the rest is the same as Application Example 1.

The preparation method of the oil-controlling and anti-inflammatory lotion described in this comparative application example is the same as that of application example 1.

Application Comparative Example 15:

An application comparative example of the oil-controlling and anti-inflammatory lotion of the present invention is different from Application Example 1 in that 33.5% of the oil-controlling and anti-inflammatory composition of Example 1 is replaced with 35% of the oil-controlling and anti-inflammatory composition of Comparative Example 15; the rest is the same as Application Example 1.

The preparation method of the oil-controlling and anti-inflammatory lotion described in this comparative application example is the same as that of application example 1.

Test Example 1: Oil Control Efficacy Test

1. Test instrument: sebum tester; Antera-3D; Test environment conditions: temperature 21℃±1℃; humidity 50%±10%RH.

Test samples: samples of Example 1-5 and oil-controlling and anti-inflammatory lotions prepared by using Comparative Examples 1-15.

2. Selection of subjects

① Age 18-65 years old; ② Those with oily skin; ③ Those who are not sensitive to commonly used cosmetics; ④ Those with obvious acne, closed comedones, and acne-prone skin; ⑤ Those with no history of photosensitivity and those who have used drugs that affect photosensitivity recently; ⑥ The test site has no inflammation, scars, pigmented moles, hirsutism, etc. caused by etiology; ⑦ Those who have not participated in other clinical studies in the past three months, and the test site has not received skin treatment, beauty treatment, or other tests that may affect the results.

Exclusion criteria for subjects: ① Those with allergic constitution, allergic dermatitis, skin diseases or history of diseases (severe freckles, atopic dermatitis, psoriasis, eczema, severe acne, etc.), and those who are clinically judged to be unsuitable for participating in the project; ② Those with large birthmarks, scratches, white spots, pigmented moles, keloids, and other skin manifestations on the face that affect the test; ③ Pregnant or lactating women.

3. Testing process

(1) Test parts and test equipment

Table 4 Test parts and test equipment

(2) Test sample usage

(2.1) Application site: forehead test area; Frequency of use: single application; Directions: After cleansing, shake well according to the instructions and take an appropriate amount of this sample, apply evenly on the face, and gently massage or pat until absorbed.

(2.2) Test process

① Recruit volunteers according to the requirements and sign the written informed consent. Before enrollment, ask the subjects a series of questions about their medical history, health status, etc. according to the inclusion and exclusion criteria;

② The subjects selected for the formal test were divided into groups according to the stratified random method to ensure the balance of the amount of oil that may affect the test results. Ten subjects were assigned to each sample for testing, and they were randomly distributed on the left and right halves of the subject's face to ensure that there was no significant difference in the initial value; the tested area was the forehead;

③ Rest in a constant temperature and humidity chamber for 30 minutes. During this period, the subjects are not allowed to drink water or beverages. The forehead of the subjects is exposed. Keep relaxed and avoid touching the test area. During the rest period, use a skin marker pen to mark a 3cm*3cm square on the eyebrow arches on both sides of the forehead, with an interval of more than 1cm, as the control area;

④In a constant temperature and humidity room, the subjects cleaned their faces with alkaline soap, rinsed with water, and then dried their faces with non-chip absorbent facial tissue. Within 3 minutes after cleansing, the initial value of skin oil was tested, and then the product was evenly applied to half of the face according to the product usage instructions;

⑤ At the set measurement time points (2 hours, 4 hours, 8 hours), use a sebum meter to test the oil content of the marked parts;

⑥ During the test, if the subject experiences any adverse skin reaction during the use of the sample, the test should be terminated immediately and the subject should be given appropriate medical treatment. The adverse reaction should be recorded.

4. Result calculation

Oil control data collation: The output data is the average value of 10 people in each group, and the results are shown in Table 5.

Hemoglobin data collation: The data at 0d and 28d were measured, and the output data were the average values of 10 people in each group. The hemoglobin reduction rate was calculated according to formula (1). The results are shown in Table 6.

Hemoglobin reduction rate = (28d hemoglobin value - 0d hemoglobin value) / 0d hemoglobin value × 100% -

Formula 1)

Table 5 Analysis of differences in skin oil content

Table 6 Hemoglobin reduction rate results

Application Examples Hemoglobin reduction rate Application Example 1 -62.0% Application Example 2 -35.70% Application Example 3 -38.30% Application Example 4 -49.10% Application Example 5 -52.80% Application Comparative Example 1 -8.8% Application Comparative Example 2 1.2% Application Comparative Example 3 -12.7% Application Comparative Example 4 -17.9% Application Comparative Example 5 -21.7% Application Comparative Example 6 2.1% Application Comparative Example 7 -2.7% Application Comparative Example 8 -0.8% Application Comparative Example 9 -7.2% Application Comparative Example 10 -9.8% Application Comparative Example 11 0.5% Application Comparative Example 12 -4.3% Application Comparative Example 13 -3.4% Application Comparative Example 14 -11.1% Application Comparative Example 15 7.8%

From the results in Table 5, it can be seen that compared with comparative examples 1 to 15, the oil-controlling and anti-inflammatory lotions prepared using examples 1 to 5 have better oil-control effects on the subjects. Among them, the oil-controlling and anti-inflammatory lotion prepared using example 1 has the best effect of reducing excessive oil accumulation, optimizing sebum quality, and improving overall skin condition.

From the results in Table 6, it can be seen that compared with comparative examples 1 to 15, the oil-controlling anti-inflammatory lotions prepared using examples 1 to 5 have more obvious anti-inflammatory effects on the subjects. Among them, the oil-controlling anti-inflammatory lotion prepared using example 1 has the best anti-inflammatory effect and the best effect in improving the overall skin condition.

In summary, the most preferred formula of the oil-controlling and anti-inflammatory lotion of the present invention is the oil-controlling and anti-inflammatory lotion prepared in Example 1.

Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims (10)

1. The oil-control anti-inflammatory composition is characterized by comprising the following components in parts by weight: 0.1-2 parts of octanoylglycine, 0.1-1 part of sea sludge, 0.1-5 parts of grape (VITIS VINIFERA) flower extract, 0.1-5 parts of myrtle (RHODOMYRTUS TOMENTOSA) fruit extract, 0.1-5 parts of Antarctic arbuscular algae (DURVILLEA ANTARTICA) extract, 0.1-5 parts of rosewood (BIXA ORELLANA) seed extract and 1-35 parts of yeast/barley seed fermentation product filtrate.

2. The oil control anti-inflammatory composition according to claim 1, comprising the following components in parts by weight: 1 part of octanoylglycine, 0.5 part of sea sludge, 3 parts of grape (VITIS VINIFERA) flower extract, 3 parts of myrtle (RHODOMYRTUS TOMENTOSA) fruit extract, 3 parts of Antarctic arbuscular algae (DURVILLEA ANTARTICA) extract, 3 parts of rosewood (BIXA ORELLANA) seed extract and 20 parts of yeast/barley seed fermentation product filtrate.

3. Use of the oil-controlling anti-inflammatory composition according to any one of claims 1-2 for the preparation of cosmetics.

4. The use according to claim 3, wherein the cosmetic product is a lotion.

5. An oil-controlling anti-inflammatory lotion comprising the oil-controlling anti-inflammatory composition according to any one of claims 1 to 2; the weight percentage of the oil-control anti-inflammatory composition in the oil-control anti-inflammatory toning lotion is 1.6-58%.

6. The oil-controlling anti-inflammatory toning lotion according to claim 5, further comprising an adsorbent, a chelating agent, a humectant, a pH adjuster, an antioxidant, and water.

7. The oil-control anti-inflammatory toning lotion according to claim 6, comprising the following components in percentage by weight: 1.6 to 58 percent of oil-controlling anti-inflammatory composition, 0.1 to 0.5 percent of adsorbent, 0.03 to 0.06 percent of chelating agent, 6.51 to 18.05 percent of humectant, 0.1 to 2 percent of pH regulator, 0.4 to 0.6 percent of antioxidant and the balance of water.

8. The oil-controlling anti-inflammatory toning lotion according to claim 6 or 7, wherein the adsorbent is hectorite; the chelating agent is disodium EDTA; the humectant comprises at least one of butanediol, 1, 2-hexanediol, allantoin, beta-glucan and glycerol; the pH regulator is arginine; the antioxidant is p-hydroxyacetophenone.

9. A method for preparing the oil-control anti-inflammatory toning lotion according to any one of claims 5 to 8, comprising the steps of:

(1) Mixing the adsorbent with 21% -79% of water, heating, homogenizing and stirring, adding the chelating agent, 0.1% -1% of oil-control anti-inflammatory composition and 1.1% -10.4% of humectant, uniformly mixing, stirring and cooling to obtain a mixture A;

(2) Mixing an antioxidant and 5.4% -7.6% of humectant, heating for dissolution, adding the mixture into the mixture A obtained in the step (1), stirring, and cooling to obtain a mixture B;

(3) Mixing 0.1% -2% of oil-control anti-inflammatory composition, pH regulator and the rest of water, heating for dissolution, adding into the mixture B obtained in the step (2), stirring, adding the rest of oil-control anti-inflammatory composition and the rest of humectant, uniformly mixing, stirring, homogenizing and cooling to obtain the oil-control anti-inflammatory toning lotion.

10. The method for preparing oil-controlling anti-inflammatory toning lotion according to claim 9, comprising at least one of the following (a) - (d):

(a) In the step (1), the heating temperature is 80-85 ℃; the homogenization speed is 3000rpm; the temperature is reduced to 60 ℃;

(b) In the step (2), the heating temperature is 60 ℃; the temperature is reduced to 45 ℃;

(c) In the step (3), the heating temperature is 80 ℃; the homogenizing condition is homogenizing at 3000rpm for 2min; the temperature is reduced to 38 ℃;

(d) In the steps (1), (2) and (3), the stirring speed is 15-20rpm.