CN118022864B - Microfluidic chip - Google Patents
Microfluidic chip Download PDFInfo
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- CN118022864B CN118022864B CN202410061525.XA CN202410061525A CN118022864B CN 118022864 B CN118022864 B CN 118022864B CN 202410061525 A CN202410061525 A CN 202410061525A CN 118022864 B CN118022864 B CN 118022864B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
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Abstract
The application discloses a micro-fluidic chip, which comprises: the micro-fluidic liquid drop driving device comprises a first driving electrode, a second driving electrode, a third driving electrode and an auxiliary electrode group, wherein the first driving electrode, the second driving electrode and the third driving electrode are arranged at intervals, a first moving path is arranged between the first driving electrode and the second driving electrode, a specific second moving path is arranged between the second driving electrode and the third driving electrode, at least one of the first moving path and the second moving path transversely extends, the other one of the first moving path and the second moving path longitudinally extends, a first diagonal path is arranged between the first driving electrode and the third driving electrode, the auxiliary electrode group is arranged on the first diagonal path, and voltage provided by the auxiliary electrode group is arranged between the first driving electrode and the third driving electrode so as to drive micro-fluidic liquid drops to move along the first diagonal path. The technical scheme of the application can effectively improve the movement efficiency of the liquid drops.
Description
Technical Field
The application belongs to the technical field of analysis and detection, and particularly relates to a microfluidic chip.
Background
The microfluidic chip can integrate multiple steps in biological, chemical and medical analysis processes on one micron-sized chip, and automatically complete the analysis process. Wherein the microfluidic chip typically drives the movement of the droplet by a dielectric wetting effect, i.e. by applying a voltage across the electrodes, changing the droplet contact angle, thereby driving the movement of the droplet.
The electrode arrangement is generally horizontally arranged or vertically arranged in the same plane, and the liquid drops can move horizontally or vertically in the same plane under the drive of the electrodes. It is sometimes necessary for the droplet to move in a diagonal direction, but the two electrodes are far apart in the diagonal direction, and generally cannot be driven effectively. For this reason, it is necessary to complete the movement in two steps by combining the horizontal and vertical movements, and the distance of movement is also long, resulting in a low efficiency of movement of the droplets.
Disclosure of Invention
The application aims to provide a microfluidic chip which can effectively improve the movement efficiency of liquid drops.
Other features and advantages of the application will be apparent from the following detailed description, or may be learned by the practice of the application.
According to an aspect of an embodiment of the present application, there is provided a microfluidic chip including: the microfluidic chip comprises a first driving electrode, a second driving electrode and a third driving electrode, wherein the first driving electrode, the second driving electrode and the third driving electrode are arranged at intervals, a first moving path is arranged between the first driving electrode and the second driving electrode, a specific second moving path is arranged between the second driving electrode and the third driving electrode, at least one of the first moving path and the second moving path transversely extends, the other one of the first moving path and the second moving path longitudinally extends, a first diagonal path is arranged between the first driving electrode and the third driving electrode, and the microfluidic chip further comprises:
The auxiliary electrode group is arranged on the first diagonal path, and the voltage provided by the auxiliary electrode group is positioned between the first driving electrode and the third driving electrode so as to drive the microfluidic liquid drops to move along the first diagonal path.
In one aspect, the auxiliary electrode group includes a first auxiliary electrode, and the first auxiliary electrode is disposed in the first diagonal path.
In one aspect, the microfluidic chip further comprises: and a fourth driving electrode, wherein a third moving path is arranged between the fourth driving electrode and the first driving electrode, a fourth moving path is arranged between the fourth driving electrode and the third driving electrode, at least one of the third moving path and the fourth moving path transversely extends, the other one longitudinally extends, a second diagonal path is arranged between the fourth driving electrode and the second driving electrode, the second diagonal path and the first diagonal path form a crossing point in a crossing way, and the first auxiliary electrode is arranged at the crossing point.
In one aspect, the microfluidic chip further includes a first response switch and a second response switch, wherein a first end of the first response switch is used for receiving a first data signal, a second end of the first response switch is connected with the first driving electrode, and a control end of the first response switch responds to a first scanning signal to load the first data signal to the first driving electrode;
the first end of the second response switch is used for receiving a second data signal, the second end of the second response switch is connected with the third driving electrode, and the control end of the second response switch responds to a second scanning signal and loads the second data signal to the third driving electrode;
The microfluidic chip further comprises a third response switch and a fourth response switch, wherein the first end of the third response switch is used for receiving a first data signal and a second data signal, the second end of the third response switch is connected with the first end of the fourth response switch, and the second end of the fourth response switch is connected with the first auxiliary electrode;
The control end of the third response switch responds to the first scanning signal and loads the first data signal and the second data signal to the first end of the fourth response switch, and the control end of the fourth response switch responds to the second scanning signal and loads the first data signal and the second data signal to the first auxiliary electrode so as to drive the microfluidic droplet to move along the first diagonal path;
the microfluidic chip further comprises a fifth response switch and a sixth response switch, wherein a first end of the fifth response switch is used for receiving a third data signal, a second end of the fifth response switch is connected with the second driving electrode, and a control end of the fifth response switch responds to a third scanning signal to load the third data signal to the second driving electrode;
The first end of the sixth response switch is used for receiving a fourth data signal, the second end of the sixth response switch is connected with the fourth driving electrode, and the control end of the sixth response switch responds to a fourth scanning signal and loads the fourth data signal to the fourth driving electrode;
The microfluidic chip further comprises a seventh response switch and an eighth response switch, wherein a first end of the seventh response switch is used for receiving a third data signal and a fourth data signal, a second end of the seventh response switch is connected with a first end of the eighth response switch, and a second end of the eighth response switch is connected with the first auxiliary electrode;
The control end of the seventh response switch responds to the third scanning signal to load the third data signal and the fourth data signal to the first end of the eighth response switch, and the control end of the eighth response switch responds to the fourth scanning signal to load the third data signal and the fourth data signal to the first auxiliary electrode so as to drive the microfluidic droplet to move along the second diagonal path.
In one aspect, the auxiliary electrode group includes two first auxiliary electrodes, the two first auxiliary electrodes are disposed at intervals, and the two first auxiliary electrodes are disposed symmetrically at the center point of the first diagonal path.
In one aspect, the microfluidic chip further comprises: a fourth driving electrode forming a third moving path between the fourth driving electrode and the first driving electrode, a fourth moving path between the fourth driving electrode and the third driving electrode, a second diagonal path between the fourth driving electrode and the second driving electrode, the second diagonal path crossing the first diagonal path to form a crossing point, the crossing point being a center point of the first diagonal path;
The auxiliary electrode group further comprises two second auxiliary electrodes, the two second auxiliary electrodes are arranged on the second diagonal paths and symmetrically arranged at the crossing points, and the two second auxiliary electrodes are used for driving the microfluidic liquid drops to move along the second diagonal paths.
In one aspect, the microfluidic chip further includes a first response switch and a second response switch, wherein a first end of the first response switch is used for receiving a first data signal, a second end of the first response switch is connected with the first driving electrode, and a control end of the first response switch is used for responding to a first scanning signal so as to load the first data signal to the first driving electrode;
the first end of the second response switch is used for receiving a second data signal, the second end of the second response switch is connected with the third driving electrode, and the control end of the second response switch responds to a second scanning signal and loads the second data signal to the third driving electrode;
The microfluidic chip further comprises a third response switch and a fourth response switch, wherein a first end of the third response switch is used for receiving a first data signal and a second data signal, a second end of the third response switch is connected with a first end of the fourth response switch, and a second end of the fourth response switch is respectively connected with two first auxiliary electrodes;
the control end of the third response switch responds to the first scanning signal and loads the first data signal and the second data signal to the first end of the fourth response switch, and the control end of the fourth response switch responds to the second scanning signal and loads the first data signal and the second data signal to the two first auxiliary electrodes.
In one aspect, the microfluidic chip includes a first substrate, a second substrate, and a common electrode disposed opposite to the first substrate, the common electrode disposed on a side of the first substrate facing the second substrate, and the first driving electrode, the second driving electrode, and the third driving electrode disposed on a side of the second substrate facing the first substrate.
In one aspect, the microfluidic chip includes a first hydrophobic layer and a second hydrophobic layer, the first hydrophobic layer is disposed on a surface of the common electrode facing the second substrate, the second hydrophobic layer is disposed on a surface of the first driving electrode facing the first substrate, and the second hydrophobic layer extends to cover the second driving electrode and the third driving electrode.
In one aspect, the microfluidic chip further includes two dielectric layers, one of which is disposed between the first hydrophobic layer and the common electrode, and the other of which is disposed between the second hydrophobic layer and the first driving electrode.
In the present application, a first diagonal path is provided between the first driving electrode and the third driving electrode, and the auxiliary electrode group is provided on the first diagonal path. Since the voltage supplied by the auxiliary electrode group is located between the first driving electrode and the third driving electrode. One of the first drive electrode and the third drive electrode has a higher voltage, and the other has a lower voltage. Under the cooperation of the auxiliary electrode group, the liquid drop microfluid can directly move along the first diagonal path, so that the moving distance is shortened, and the moving efficiency of liquid drops is improved.
It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the application as claimed.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the application and together with the description, serve to explain the principles of the application. It is evident that the drawings in the following description are only some embodiments of the present application and that other drawings may be obtained from these drawings without inventive effort for a person of ordinary skill in the art.
Fig. 1 schematically shows a schematic structure of a microfluidic chip of the present application.
Fig. 2 schematically shows another structural schematic of the microfluidic chip of the present application.
Fig. 3 schematically shows a schematic diagram of a driving circuit structure of the microfluidic chip of fig. 1 according to the present application.
Fig. 4 schematically shows another driving circuit structure of the microfluidic chip of fig. 1 according to the present application.
Fig. 5 schematically illustrates a driving circuit structure of a first auxiliary electrode of the microfluidic chip of fig. 2 according to the present application.
Fig. 6 schematically illustrates another driving circuit structure of the first auxiliary electrode of the microfluidic chip of fig. 2 according to the present application.
Fig. 7 schematically shows a schematic circuit configuration of the microfluidic chip of fig. 2 according to the present application in which two first auxiliary electrodes are separately powered.
Fig. 8 schematically illustrates a driving circuit structure of a second auxiliary electrode of the microfluidic chip of fig. 2 according to the present application.
Fig. 9 schematically illustrates a circuit configuration of the microfluidic chip of fig. 2 in which two second auxiliary electrodes are separately powered according to the present application.
Fig. 10 schematically shows a schematic cross-sectional structure of a microfluidic chip of the present application.
The reference numerals are explained as follows:
110. A first driving electrode; 120. a second driving electrode; 130. a third driving electrode; 140. a fourth driving electrode; 150. an auxiliary electrode group; 160. a common electrode; 210. a first movement path; 220. a second movement path; 230. a third movement path; 240. a fourth movement path; t1, a first response switch; t2, a second response switch; t3, a third response switch; t4, a fourth response switch; t5, a fifth response switch; t6, sixth response switch; t7, seventh response switch; t8, eighth responsive switch; dataA, a first data signal; a DataC, a second data signal; dataB, a third data signal; dataD, fourth data signals; gateA, a first scanning signal; gateC, a second scanning signal; gateB, a third scanning signal; gateD, fourth scan signals; 310. a first substrate; 320. a second substrate; 410. a first diagonal path; 420. a second diagonal path; vcom, common voltage; 510. a first hydrophobic layer; 520. a second hydrophobic layer; 530. a dielectric layer; 600. microfluidic of droplets; 710. a source electrode; 720. a drain electrode; 730. an active layer; 740. a gate; 810. a first insulating layer; 820. a second insulating layer; 151. a first auxiliary electrode; 152. and a second auxiliary electrode.
Detailed Description
Example embodiments will now be described more fully with reference to the accompanying drawings. However, the exemplary embodiments may be embodied in many forms and should not be construed as limited to the examples set forth herein; rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the concept of the example embodiments to those skilled in the art.
Referring to fig. 1, the present application provides a microfluidic chip, including: the first, second and third driving electrodes 110, 120 and 130 are generally located in the same plane. The first driving electrode 110, the second driving electrode 120 and the third driving electrode 130 are arranged at intervals, a first moving path 210 is arranged between the first driving electrode 110 and the second driving electrode 120, a specific second moving path 220 is arranged between the second driving electrode 120 and the third driving electrode 130, at least one of the first moving path 210 and the second moving path 220 extends transversely, the other one extends longitudinally, a first diagonal path 410 is arranged between the first driving electrode 110 and the third driving electrode 130, and the microfluidic chip further comprises: the auxiliary electrode set 150, the auxiliary electrode set 150 is disposed on the first diagonal path 410. In operation, power is supplied to the first driving electrode 110, the third driving electrode 130, and the auxiliary electrode group 150, respectively. The voltage provided by the auxiliary electrode set 150 is located between the first driving electrode 110 and the third driving electrode 130, a voltage difference is formed between the first driving electrode 110 and the auxiliary electrode set 150, and a voltage difference is also formed between the third driving electrode 130 and the auxiliary electrode set 150, so as to drive the microfluidic droplet to move along the first diagonal path 410 under the action of the voltage difference.
In the present embodiment, a first diagonal path 410 is provided between the first driving electrode 110 and the third driving electrode 130, and the auxiliary electrode group 150 is disposed on the first diagonal path 410. Since the voltage supplied from the auxiliary electrode group 150 is located between the first driving electrode 110 and the third driving electrode 130. One of the first driving electrode 110 and the third driving electrode 130 has a higher voltage, and the other has a lower voltage. Under the cooperation of the auxiliary electrode set 150, the droplet micro-flow 600 can directly move along the first diagonal path 410, the linear distance between two points is shortest, and compared with the middle of the droplet micro-flow passing through the second driving electrode 120, the moving distance is greatly shortened, and the moving efficiency of the droplet is improved.
For example, the voltage of the first driving electrode 110 is higher than that of the third driving electrode 130, and the voltage is from high to low, so that the liquid drops can move from the first driving electrode 110 to the auxiliary electrode 150 and then from the auxiliary electrode 150 to the third driving electrode 130.
For another example, the voltage of the third driving electrode 130 is higher than that of the first driving electrode 110, and the voltage is from high to low, so that the liquid drops can move from the third driving electrode 130 to the auxiliary electrode 150 and then from the auxiliary electrode 150 to the first driving electrode 110.
The number of electrodes in the auxiliary electrode group 150 in the present application includes at least two cases.
The first electrode arrangement number is that the auxiliary electrode set 150 includes a first auxiliary electrode 151, and a first auxiliary electrode 151 is disposed in the first diagonal path 410. The first auxiliary electrode 151 may be located at any position on the first diagonal path 410, may be adjacent to the first driving electrode 110, may be adjacent to the third driving electrode 130, or may be located between the first driving electrode 110 and the third driving electrode 130. The movement of the driving droplet is completed by supplying voltages of different magnitudes to the first auxiliary electrode 151.
Further, the microfluidic chip further includes: the fourth driving electrode 140, a third moving path 230 is provided between the fourth driving electrode 140 and the first driving electrode 110, a fourth moving path 240 is provided between the fourth driving electrode 140 and the third driving electrode 130, at least one of the third moving path 230 and the fourth moving path 240 extends transversely, the other extends longitudinally, a second diagonal path 420 is provided between the fourth driving electrode 140 and the second driving electrode 120, the second diagonal path 420 and the first diagonal path 410 intersect to form an intersection point, and the first auxiliary electrode 151 is disposed at the intersection point.
It is understood that, at this time, the first auxiliary electrode 151 is disposed at an intermediate point of the first driving electrode 110 and the third driving electrode 130. Meanwhile, the first auxiliary electrode 151 is also disposed at an intermediate point between the second driving electrode 120 and the fourth driving electrode 140. That is, the first auxiliary electrodes 151 are located at the crossing points, and the first auxiliary electrodes 151 are provided at the crossing points, so that the first auxiliary electrodes 151 can be used when the droplet moves in the first diagonal path 410 or the second diagonal path 420, and the number of auxiliary electrodes can be reduced. It should be noted that the first auxiliary electrode 151 can only complete the movement of the droplet in cooperation with one of the first diagonal path 410 and the second diagonal path 420 at the same time.
Referring to fig. 3, in order to smoothly drive the droplet to move, the microfluidic chip further includes a first response switch T1 and a second response switch T2, wherein a first end of the first response switch T1 is used for receiving a first data signal DataA, a second end of the first response switch T1 is connected to the first driving electrode 110, and a control end of the first response switch T1 responds to the first scanning signal GateA to load a first data signal DataA to the first driving electrode 110; the first end of the second response switch T2 is configured to receive the second data signal DataC, the second end of the second response switch T2 is connected to the third driving electrode 130, and the control end of the second response switch T2 is configured to load the second data signal DataC to the third driving electrode 130 in response to the second scan signal GateC; the first data signal DataA and the second data signal DataC may be understood as voltage signals, one of which is large and the other of which is small. Typically, one of the first data signal DataA and the second data signal DataC is positive and the other is negative. For example, the first data signal DataA is a positive voltage and the second data signal DataC is a negative voltage.
For the droplet to move along the first diagonal path 410, the microfluidic chip further includes a third response switch T3 and a fourth response switch T4, wherein a first end of the third response switch T3 is configured to receive the first data signal DataA and the second data signal DataC, a second end of the third response switch T3 is connected to a first end of the fourth response switch T4, and a second end of the fourth response switch T4 is connected to the first auxiliary electrode 151; the control terminal of the third response switch T3 responds to the first scan signal GateA to load the first data signal DataA and the second data signal DataC to the first terminal of the fourth response switch T4, the control terminal of the fourth response switch T4 responds to the second scan signal GateC to load the first data signal DataA and the second data signal DataC to the first auxiliary electrode 151, the first data signal DataA and the second data signal DataC jointly act on the first auxiliary electrode 151, a positive negative voltage, positive and negative cancellation, and the voltage on the first auxiliary electrode 151 is between the voltages of the first data signal DataA and the second data signal DataC to drive the microfluidic droplet to move along the first diagonal path 410.
The first terminal of the third response switch T3 is configured to receive the first data signal DataA and the second data signal DataC, and to make full use of the already provided data signal.
Referring to fig. 4, the first terminal of the third response switch T3 may also receive other voltage signals, such as a fifth data signal, so long as the voltage applied to the first auxiliary electrode 151 is ensured to be between the voltages of the first data signal DataA and the second data signal DataC, so as to effectively form a voltage difference.
For the droplet moving along the second diagonal path 420, the microfluidic chip further includes a fifth response switch T5 and a sixth response switch T6, wherein a first end of the fifth response switch T5 is configured to receive the third data signal DataB, a second end of the fifth response switch T5 is connected to the second driving electrode 120, and a control end of the fifth response switch T5 is configured to load the third data signal DataB to the second driving electrode 120 in response to the third scan signal GateB; the first end of the sixth response switch T6 is configured to receive the fourth data signal DataD, the second end of the sixth response switch T6 is connected to the fourth driving electrode 140, and the control end of the sixth response switch T6 is configured to respond to the fourth scan signal GateD and load the fourth data signal DataD to the fourth driving electrode 140; likewise, the third data signal DataB and the fourth data signal DataD may also be understood as voltage signals, where one of the voltages of the third data signal DataB and the fourth data signal DataD is large and the other is small. Typically, one of the third data signal DataB and the fourth data signal DataD is positive and the other is negative. For example, the third data signal DataB is a positive voltage and the fourth data signal DataD is a negative voltage.
The microfluidic chip further comprises a seventh response switch T7 and an eighth response switch T8, wherein a first end of the seventh response switch T7 is used for receiving the third data signal DataB and the fourth data signal DataD, a second end of the seventh response switch T7 is connected with the first end of the eighth response switch T8, and a second end of the eighth response switch T8 is connected with the first auxiliary electrode 151; the control terminal of the seventh response switch T7 responds to the third scan signal GateB to load the third data signal DataB and the fourth data signal DataD to the first terminal of the eighth response switch T8, the control terminal of the eighth response switch T8 responds to the fourth scan signal GateD to load the third data signal DataB and the fourth data signal DataD to the first auxiliary electrode 151, the third data signal DataB and the fourth data signal DataD act together on the first auxiliary electrode 151 with a positive negative voltage, positive and negative cancellation, and the voltage on the first auxiliary electrode 151 is between the voltages of the third data signal DataB and the fourth data signal DataD to drive the microfluidic droplet to move along the second diagonal path 420.
Referring to fig. 4, it is also known that the first end of the seventh response switch T7 may also receive other voltage signals, such as the sixth data signal, so long as the voltage applied to the first auxiliary electrode 151 is ensured to be between the voltages of the third data signal DataB and the fourth data signal DataD, so as to effectively form a voltage difference, and the driving droplet is moved from the third driving electrode 130 to the fourth driving electrode 140 along the second diagonal path 420.
Referring to fig. 2, in the case of the second electrode arrangement number, the auxiliary electrode set 150 includes two first auxiliary electrodes 151, the two first auxiliary electrodes 151 are arranged at intervals, and the two first auxiliary electrodes 151 are symmetrically arranged at the center point of the first diagonal path 410. The two first auxiliary electrodes 151 are used only in conjunction with the first diagonal path 410, so that the control process is simplified.
Further, the microfluidic chip further includes: the fourth driving electrodes 140, 140 form a third moving path 230 between the fourth driving electrode and the first 110 driving electrode, a fourth moving path 240 is formed between the fourth driving electrode 140 and the third driving electrode 130, a second diagonal path 420 is formed between the fourth driving electrode 140 and the second driving electrode 120, the second diagonal path 420 crosses the first diagonal path 410 to form a crossing point, and the crossing point is the center point of the first diagonal path 410; the auxiliary electrode set 150 further includes two second auxiliary electrodes 152, where the two second auxiliary electrodes 152 are disposed in the second diagonal path 420 and symmetrically disposed at the intersection, and the two second auxiliary electrodes 152 are used for driving the microfluidic droplet to move along the second diagonal path 420. The use of the second auxiliary electrode 152 and the first auxiliary electrode 151 does not conflict, so that the design of control lines is facilitated, and the line arrangement is simplified.
Referring to fig. 2 and 5, in case of the second electrode arrangement number, in order to drive the droplet to move, the microfluidic chip further includes a first response switch T1 and a second response switch T2, wherein a first end of the first response switch T1 is used for receiving the first data signal DataA, a second end of the first response switch T1 is connected to the first driving electrode 110, and a control end of the first response switch T1 is responsive to the first scan signal GateA to load the first data signal DataA to the first driving electrode 110; the first end of the second response switch T2 is configured to receive the second data signal DataC, the second end of the second response switch T2 is connected to the third driving electrode 130, and the control end of the second response switch T2 is configured to load the second data signal DataC to the third driving electrode 130 in response to the second scan signal GateC; the first data signal DataA and the second data signal DataC may be understood as voltage signals, one of which is large and the other of which is small. Typically, one of the first data signal DataA and the second data signal DataC is positive and the other is negative. For example, the first data signal DataA is a positive voltage and the second data signal DataC is a negative voltage.
The microfluidic chip further comprises a third response switch T3 and a fourth response switch T4, wherein a first end of the third response switch T3 is used for receiving a first data signal DataA and a second data signal DataC, a second end of the third response switch T3 is connected with a first end of the fourth response switch T4, and a second end of the fourth response switch T4 is respectively connected with two first auxiliary electrodes 151;
The control terminal of the third response switch T3 responds to the first scan signal GateA to load the first data signal DataA and the second data signal DataC to the first terminal of the fourth response switch T4, and the control terminal of the fourth response switch T4 responds to the second scan signal GateC to load the first data signal DataA and the second data signal DataC to the two first auxiliary electrodes 151. The first data signal DataA and the second data signal DataC act together on the two first auxiliary electrodes 151, a positive negative voltage, the positive and negative canceling, the voltage on the two first auxiliary electrodes 151 being between the voltages of the first data signal DataA and the second data signal DataC, thereby driving the droplet to move along the first diagonal path 410.
Referring to fig. 6, the first terminal of the third response switch T3 may receive a fifth data signal having a voltage between the voltages of the first data signal DataA and the second data signal DataC.
Referring to fig. 7, in the above embodiment, the voltages on the two first auxiliary electrodes 151 are equal, in order to drive the droplet to move between the two first auxiliary electrodes 151, the first terminal of the third responsive switch T3 receives the fifth data signal, the first terminal of the fourth responsive switch T4 receives the sixth data signal, one of the fifth data signal and the sixth data signal is high, and the other is low. Thereby driving the droplet to move between the two first auxiliary electrodes 151.
Referring to fig. 2 and 8, the microfluidic chip further includes a fifth response switch T5 and a sixth response switch T6, wherein a first end of the fifth response switch T5 is configured to receive the third data signal DataB, a second end of the fifth response switch T5 is connected to the second driving electrode 120, and a control end of the fifth response switch T5 is configured to respond to the third scan signal GateB to load the third data signal DataB to the second driving electrode 120; the first terminal of the sixth response switch T6 is configured to receive the fourth data signal DataD, the second terminal of the sixth response switch T6 is connected to the fourth driving electrode 140, and the control terminal of the sixth response switch T6 is configured to load the fourth data signal DataD to the fourth driving electrode 140 in response to the fourth scan signal GateD.
The microfluidic chip further comprises a seventh response switch T7 and an eighth response switch T8, wherein a first end of the seventh response switch T7 is used for receiving the third data signal DataB and the fourth data signal DataD, a second end of the seventh response switch T7 is connected with the first end of the eighth response switch T8, and a second end of the eighth response switch T8 is respectively connected with the two second auxiliary electrodes 152;
The control terminal of the seventh response switch T7 is responsive to the third scan signal GateB for loading the third data signal DataB and the fourth data signal DataD to the first terminal of the eighth response switch T8, and the control terminal of the eighth response switch T8 is responsive to the fourth scan signal GateD for loading the third data signal DataB and the fourth data signal DataD to the two second auxiliary electrodes 152.
Referring to fig. 9, the voltages on the two second auxiliary electrodes 152 are equal, and in order to drive the droplet to move between the two second auxiliary electrodes 152, the first terminal of the seventh responsive switch T7 receives the fifth data signal, the first terminal of the eighth responsive switch T8 receives the sixth data signal, one of the voltages of the fifth data signal and the sixth data signal is high, and the other is low. Thereby driving the droplet to move between the two second auxiliary electrodes 152. The response switch may be a TFT (thin film transistor switch) or a MOS transistor.
Referring to fig. 10, the microfluidic chip includes a first substrate 310, a second substrate 320, and a common electrode 160, wherein the first substrate 310 and the second substrate 320 are disposed opposite to each other, the common electrode 160 is disposed on a side of the first substrate 310 facing the second substrate 320, and the first driving electrode 110, the second driving electrode 120, and the third driving electrode 130 are disposed on a side of the second substrate 320 facing the first substrate 310. The first substrate 310 and the second substrate 320 are generally transparent materials, and glass or plastic is used. The first, second and third driving electrodes 110, 120 and 130 and the common electrode 160 may be ITO conductive layers or metal conductive layers. The common electrode 160 supplies a common voltage, and the first, second, third and fourth driving electrodes 110, 120, 130 and 140 generate voltage differences between the common electrodes 160, respectively, but the generated voltage differences are different in magnitude. The droplet moves from a position where the voltage difference is large to a position where the voltage difference is small.
The microfluidic chip includes a first hydrophobic layer 510 and a second hydrophobic layer 520, the first hydrophobic layer 510 is disposed on a surface of the common electrode 160 facing the second substrate 320, the second hydrophobic layer 520 is disposed on a surface of the first driving electrode 110 facing the first substrate 310, and the second hydrophobic layer 520 extends to cover the second driving electrode 120 and the third driving electrode 130. By providing the first and second hydrophobic layers 510 and 520, the contact angle of the droplet can be reduced, thereby facilitating driving of the droplet.
In one aspect, the microfluidic chip further includes two dielectric layers 530, one dielectric layer 530 being disposed between the first hydrophobic layer 510 and the common electrode 160, and the other dielectric layer 530 being disposed between the second hydrophobic layer 520 and the first driving electrode 110. The dielectric layer 530 can increase a capacitance value between the first driving electrode 110 and the common electrode 160 so as to maintain a moving state of the droplet. In the present application, the first response switch T1 includes a source electrode 710, a drain electrode 720, an active layer 730, and a gate electrode 740, the gate electrode 740 is disposed on the upper surface of the second substrate 320, the active layer 730 is disposed above the gate electrode 740, a first insulating layer 810 is disposed between the active layer 730 and the gate electrode 740, the source electrode 710 and the drain electrode 720 are disposed at both sides of the active layer 730, a second insulating layer 820 is disposed between the source electrode 710 and the drain electrode 720 and the first driving electrode 110, an opening is formed in the second insulating layer 820, and the first driving electrode 110 is connected through the opening drain electrode 720 so as to supply power to the first driving electrode 110.
Other embodiments of the application will be apparent to those skilled in the art from consideration of the specification and practice of the application disclosed herein. This application is intended to cover any variations, uses, or adaptations of the application following, in general, the principles of the application and including such departures from the present disclosure as come within known or customary practice within the art to which the application pertains.
It is to be understood that the application is not limited to the precise arrangements and instrumentalities shown in the drawings, which have been described above, and that various modifications and changes may be effected without departing from the scope thereof. The scope of the application is limited only by the appended claims.
Claims (5)
1. A microfluidic chip, the microfluidic chip comprising: the micro-fluidic chip comprises a first driving electrode, a second driving electrode and a third driving electrode, wherein the first driving electrode, the second driving electrode and the third driving electrode are arranged at intervals, a first moving path is arranged between the first driving electrode and the second driving electrode, a specific second moving path is arranged between the second driving electrode and the third driving electrode, at least one of the first moving path and the second moving path transversely extends, the other one of the first moving path and the second moving path longitudinally extends, and a first diagonal path is arranged between the first driving electrode and the third driving electrode, and the micro-fluidic chip is characterized in that the micro-fluidic chip further comprises: the auxiliary electrode group is arranged on the first diagonal path, and the voltage provided by the auxiliary electrode group is positioned between the first driving electrode and the third driving electrode so as to drive the microfluidic liquid drops to move along the first diagonal path;
the auxiliary electrode group comprises a first auxiliary electrode, and the first auxiliary electrode is arranged in the first diagonal path;
The microfluidic chip further includes: a fourth driving electrode, a third moving path is arranged between the fourth driving electrode and the first driving electrode, a fourth moving path is arranged between the fourth driving electrode and the third driving electrode, at least one of the third moving path and the fourth moving path extends transversely, the other one extends longitudinally, a second diagonal path is arranged between the fourth driving electrode and the second driving electrode, the second diagonal path and the first diagonal path form a crossing point in a crossing way, and the first auxiliary electrode is arranged at the crossing point;
The microfluidic chip further comprises a first response switch and a second response switch, wherein a first end of the first response switch is used for receiving a first data signal, a second end of the first response switch is connected with the first driving electrode, and a control end of the first response switch responds to a first scanning signal and loads the first data signal to the first driving electrode;
the first end of the second response switch is used for receiving a second data signal, the second end of the second response switch is connected with the third driving electrode, and the control end of the second response switch responds to a second scanning signal and loads the second data signal to the third driving electrode;
The microfluidic chip further comprises a third response switch and a fourth response switch, wherein the first end of the third response switch is used for receiving a first data signal and a second data signal, the second end of the third response switch is connected with the first end of the fourth response switch, and the second end of the fourth response switch is connected with the first auxiliary electrode;
The control end of the third response switch responds to the first scanning signal and loads the first data signal and the second data signal to the first end of the fourth response switch, and the control end of the fourth response switch responds to the second scanning signal and loads the first data signal and the second data signal to the first auxiliary electrode so as to drive the microfluidic droplet to move along the first diagonal path;
the microfluidic chip further comprises a fifth response switch and a sixth response switch, wherein a first end of the fifth response switch is used for receiving a third data signal, a second end of the fifth response switch is connected with the second driving electrode, and a control end of the fifth response switch responds to a third scanning signal to load the third data signal to the second driving electrode;
The first end of the sixth response switch is used for receiving a fourth data signal, the second end of the sixth response switch is connected with the fourth driving electrode, and the control end of the sixth response switch responds to a fourth scanning signal and loads the fourth data signal to the fourth driving electrode;
The microfluidic chip further comprises a seventh response switch and an eighth response switch, wherein a first end of the seventh response switch is used for receiving a third data signal and a fourth data signal, a second end of the seventh response switch is connected with a first end of the eighth response switch, and a second end of the eighth response switch is connected with the first auxiliary electrode;
The control end of the seventh response switch responds to the third scanning signal to load the third data signal and the fourth data signal to the first end of the eighth response switch, and the control end of the eighth response switch responds to the fourth scanning signal to load the third data signal and the fourth data signal to the first auxiliary electrode so as to drive the microfluidic droplet to move along the second diagonal path.
2. A microfluidic chip, the microfluidic chip comprising: the micro-fluidic chip comprises a first driving electrode, a second driving electrode and a third driving electrode, wherein the first driving electrode, the second driving electrode and the third driving electrode are arranged at intervals, a first moving path is arranged between the first driving electrode and the second driving electrode, a specific second moving path is arranged between the second driving electrode and the third driving electrode, at least one of the first moving path and the second moving path transversely extends, the other one of the first moving path and the second moving path longitudinally extends, and a first diagonal path is arranged between the first driving electrode and the third driving electrode, and the micro-fluidic chip is characterized in that the micro-fluidic chip further comprises: the auxiliary electrode group is arranged on the first diagonal path, and the voltage provided by the auxiliary electrode group is positioned between the first driving electrode and the third driving electrode so as to drive the microfluidic liquid drops to move along the first diagonal path;
the auxiliary electrode group comprises two first auxiliary electrodes, the two first auxiliary electrodes are arranged at intervals, and the two first auxiliary electrodes are symmetrically arranged at the center point of the first diagonal path;
the microfluidic chip further includes: a fourth driving electrode forming a third moving path between the fourth driving electrode and the first driving electrode, a fourth moving path between the fourth driving electrode and the third driving electrode, a second diagonal path between the fourth driving electrode and the second driving electrode, the second diagonal path crossing the first diagonal path to form a crossing point, the crossing point being a center point of the first diagonal path;
The auxiliary electrode group further comprises two second auxiliary electrodes, the two second auxiliary electrodes are arranged on the second diagonal paths and symmetrically arranged at the crossing points, and the two second auxiliary electrodes are used for driving the microfluidic liquid drops to move along the second diagonal paths;
the microfluidic chip further comprises a first response switch and a second response switch, wherein a first end of the first response switch is used for receiving a first data signal, a second end of the first response switch is connected with the first driving electrode, and a control end of the first response switch responds to a first scanning signal so as to load the first data signal to the first driving electrode;
the first end of the second response switch is used for receiving a second data signal, the second end of the second response switch is connected with the third driving electrode, and the control end of the second response switch responds to a second scanning signal and loads the second data signal to the third driving electrode;
The microfluidic chip further comprises a third response switch and a fourth response switch, wherein a first end of the third response switch is used for receiving a first data signal and a second data signal, a second end of the third response switch is connected with a first end of the fourth response switch, and a second end of the fourth response switch is respectively connected with two first auxiliary electrodes;
the control end of the third response switch responds to the first scanning signal and loads the first data signal and the second data signal to the first end of the fourth response switch, and the control end of the fourth response switch responds to the second scanning signal and loads the first data signal and the second data signal to the two first auxiliary electrodes.
3. The microfluidic chip according to claim 1 or 2, wherein the microfluidic chip comprises a first substrate, a second substrate, and a common electrode, the first substrate and the second substrate are disposed opposite to each other, the common electrode is disposed on a side of the first substrate facing the second substrate, and the first driving electrode, the second driving electrode, and the third driving electrode are disposed on a side of the second substrate facing the first substrate.
4. A microfluidic chip according to claim 3, comprising a first hydrophobic layer and a second hydrophobic layer, wherein the first hydrophobic layer is provided on a side of the common electrode facing the second substrate, the second hydrophobic layer is provided on a side of the first drive electrode facing the first substrate, and the second hydrophobic layer extends over the second drive electrode and the third drive electrode.
5. The microfluidic chip according to claim 4, further comprising two dielectric layers, one of the dielectric layers being disposed between the first hydrophobic layer and the common electrode, and the other of the dielectric layers being disposed between the second hydrophobic layer and the first driving electrode.
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