CN117883432B - New application of salvianolic acid B - Google Patents
New application of salvianolic acid B Download PDFInfo
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- CN117883432B CN117883432B CN202311806684.XA CN202311806684A CN117883432B CN 117883432 B CN117883432 B CN 117883432B CN 202311806684 A CN202311806684 A CN 202311806684A CN 117883432 B CN117883432 B CN 117883432B
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- lung cancer
- salvianolic acid
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- SNKFFCBZYFGCQN-UHFFFAOYSA-N 2-[3-[3-[1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]prop-2-enoyloxy]-3-(3,4-dihydroxyphenyl)propanoic acid Chemical compound C=1C=C(O)C=2OC(C=3C=C(O)C(O)=CC=3)C(C(=O)OC(CC=3C=C(O)C(O)=CC=3)C(O)=O)C=2C=1C=CC(=O)OC(C(=O)O)CC1=CC=C(O)C(O)=C1 SNKFFCBZYFGCQN-UHFFFAOYSA-N 0.000 title claims abstract description 48
- SNKFFCBZYFGCQN-VWUOOIFGSA-N Lithospermic acid B Natural products C([C@H](C(=O)O)OC(=O)\C=C\C=1C=2[C@H](C(=O)O[C@H](CC=3C=C(O)C(O)=CC=3)C(O)=O)[C@H](OC=2C(O)=CC=1)C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 SNKFFCBZYFGCQN-VWUOOIFGSA-N 0.000 title claims abstract description 45
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
The invention discloses a new application of salvianolic acid B. According to the invention, a lung cancer heart disease model experiment constructed by uratam and benzopyrene is used, and it is determined that salvianolic acid B and Panax notoginsenosides, especially salvianolic acid B combined with Panax notoginsenosides, can reduce the inner diameter of the end systole of the left ventricle and the left cardiac output, and reduce the thickness of the free wall of the right heart, the inner diameter of the end diastole of the right heart, the stroke volume of the right ventricle and the right cardiac output by increasing the ejection fraction of the left ventricle and the short axis shortening rate of the left ventricle, so that the heart function of a lung cancer heart disease mouse is improved. Under the condition that the heart function effect of a plurality of medicaments for treating heart-related diseases is poor for lung cancer heart diseases, the effect of improving the heart function of the salvianolic acid B combined with the total saponins of pseudo-ginseng is equivalent to that of the salmeterol xinafoate which is commonly used clinically at present, unexpected curative effects are obtained, and the medicament has wide application prospect.
Description
The application provides a split application of an application patent with application number 2023113872712, the application name of which is salvianolic acid B and/or total saponins of panax notoginseng composition and application thereof, and application date of which is 2023, 10 and 25.
Technical Field
The invention relates to a salvianolic acid B and/or pseudo-ginseng total saponin composition and application thereof.
Background
Heart disease is a type of disease involving the heart or blood vessels, including coronary heart disease, heart failure, cardiac hypertrophy, myocarditis, etc. Different heart diseases have different symptoms, such as palpitation, dyspnea, cyanosis, cough, chest pain, edema and the like, and serious pulmonary edema, respiratory failure, systemic water electrolyte disorder and the like. Heart disease is mainly caused by congenital heart disease, namely heart dysplasia in fetal period, lesions affecting heart tissues, and acquired heart disease, namely postnatal heart is caused by external or internal factors of organism. Such as coronary atherosclerotic heart disease, rheumatic heart disease, hypertensive heart disease, pulmonary heart disease, infectious heart disease, endocrine heart disease, hematopathy heart disease, nutritional metabolic heart disease, etc.
Lung cancer is also a malignant disease, and clinical studies have now found that lung cancer is very difficult to treat in combination with heart disease. At present, two treatment schemes are adopted for patients with lung cancer combined heart diseases, one is that the common medicines for treating heart diseases in clinic, such as a cardiotonic digoxin, a heart rate improving beta receptor blocker and the like, are adopted for treating the lung cancer combined heart diseases, the patients cannot benefit from the medicines, and the ARB medicines, such as the sabatistat, with better effects on treating the lung cancer combined heart diseases, have side effects of angioedema, hypotension, renal function damage and hyperkalemia. The other is mainly tumor treatment, and research shows that cisplatin which is a representative drug of the first-generation platinum anti-tumor chemotherapeutic drug is dripped into the pericardial cavity of the heart, so that the cisplatin can obviously prevent the recurrence of malignant pericardial effusion of a lung cancer patient. However, these chemotherapeutics often have certain cardiotoxicity, which may aggravate cardiac injury itself, and cisplatin instillation also has serious problems of difficult operation, high occurrence rate of adverse events and secondary loss to patients in clinic, resulting in difficult clinical application. Other targeted drugs, such as EGFR inhibitors, are less toxic and more targeted than chemotherapeutic drugs, but studies have found that they also have significant cardiotoxicity.
The natural source plant resources are rich, the method has great excavation potential in the aspect of treating lung cancer combined heart diseases, and the effective components for treating the lung cancer combined heart diseases with little side effect and good curative effect are necessary to be searched from medicinal plants, so that the medicaments for treating the lung cancer combined heart diseases are enriched, and the lung cancer combined heart diseases are benefited.
The salvianolic acid B is an active ingredient in the red sage root and has strong antioxidation, in vivo and in vitro experiments prove that the salvianolic acid B can remove oxygen free radicals and inhibit lipid peroxidation, is currently reported to be used for protecting heart or resisting tumor, and the total arasaponin is a main active substance of the pseudo-ginseng and has the effects of inhibiting platelet aggregation and increasing cerebral blood flow, and is currently used for cerebral vascular sequelae, central retinal vein occlusion, anterior ocular chamber hemorrhage and the like. There is no research evidence at present that active ingredients of the red sage root and the pseudo-ginseng have a protective effect on lung cancer combined heart diseases.
Disclosure of Invention
In order to solve the problems, the invention provides application of salvianolic acid B or total saponins of panax notoginseng in preparing medicines for preventing and/or treating lung cancer heart diseases.
The invention also provides application of the salvianolic acid B combined with the pseudo-ginseng total saponins in preparing medicines for preventing and/or treating lung cancer heart diseases.
The lung cancer heart disease refers to heart disease caused by lung cancer, and comprises the condition that the existing heart disease has progressive aggravation in the lung cancer treatment process. The research of the inventor shows that the heart disease caused by lung cancer is different from the common heart disease, and the main reason is that lung cancer cells are transferred to the pericardium, so that pericardial effusion can be caused, malignant arrhythmia, heart failure and the like can be caused, the effect of treating the heart disease by adopting the traditional heart disease treatment medicine is poor, the survival time of a patient is very short, and the clinical treatment is troublesome and the curative effect is poor.
Further, the mass ratio of the salvianolic acid B to the total saponins of panax notoginseng is 120-800:30-240, preferably 200:60.
Further, the medicament has an effect of improving cardiac function of heart disease caused by lung cancer.
Still further, the medicament has the effect of increasing left ventricular ejection fraction and left ventricular short axis shortening rate, decreasing left ventricular end systole inner diameter and left cardiac output.
Still further, the medicament has the effect of reducing the thickness of the free wall of the right heart, the inner diameter of the end diastole, the stroke volume of the right ventricle and the right cardiac output.
Further, the medicine is a medicine for preventing and treating heart failure caused by lung cancer.
The invention also provides a combined medicament for preventing and/or treating lung cancer heart disease, which is prepared from salvianolic acid B and total arasaponin which are used for simultaneous or separate administration, wherein the active ingredients of the combined medicament consist of the salvianolic acid B and the total arasaponin.
Further, the mass ratio of the salvianolic acid B to the total saponins of panax notoginseng is 120-800:30-240, preferably 200:60.
The invention finally provides a composition for preventing and/or treating lung cancer heart disease, wherein the active ingredients of the composition consist of salvianolic acid B and total saponins of pseudo-ginseng, and the composition is a preparation prepared by adding pharmaceutically acceptable auxiliary materials into the active ingredients.
Further, the mass ratio of the salvianolic acid B to the total saponins of panax notoginseng is 120-800:30-240, preferably 200:60.
The invention relates to application of salvianolic acid B and/or total arasaponin in preparing medicines for preventing and/or treating lung cancer heart diseases, and a lung cancer heart disease model experiment constructed by uratein and benzopyrene is used for determining that the salvianolic acid B and the total arasaponin, especially the salvianolic acid B combined with the total arasaponin, reduce the inner diameter of the end systole and the output of the left heart by increasing the ejection fraction of the left heart chamber and the short axis shortening rate of the left heart chamber, and reduce the thickness of the free wall of the right heart, the inner diameter of the end diastole of the right heart, the output of the right heart chamber and the output of the right heart, thereby improving the heart function of a lung cancer heart disease mouse. Under the condition that the heart function effect of a plurality of medicaments for treating heart-related diseases is poor for lung cancer heart diseases, the effect of improving the heart function of the salvianolic acid B combined with the total saponins of pseudo-ginseng is equivalent to that of the salmeterol xinafoate which is commonly used clinically at present, unexpected curative effects are obtained, and the medicament has wide application prospect.
It should be apparent that, in light of the foregoing, various modifications, substitutions and alterations can be made herein without departing from the spirit and scope of the invention as defined by the appended claims.
The above-described aspects of the present invention will be described in further detail below with reference to specific embodiments in the form of examples. It should not be understood that the scope of the above subject matter of the present invention is limited to the following examples only. All techniques implemented based on the above description of the invention are within the scope of the invention.
Drawings
Fig. 1 study roadmap.
Detailed Description
The materials, equipment and reagents used in the specific embodiments of the invention are all known products and are obtained by purchasing commercially available products.
Example 1 use of Danshen root and Sanchi monomer components in treating Lung cancer heart disease
1. Experimental reagent
Ulatin (sigma Co., USA), benzopyrene (Shanghai-derived leaf Biotechnology Co., ltd.), salvianolic acid B (Shanghai-derived leaf Biotechnology Co., ltd.), panax notoginseng saponins (Shanghai-derived leaf Biotechnology Co., ltd.), sha Kuba troxatan (Beijing Norhua pharmaceutical Co., ltd.), digoxin tablets (Chengbeide Noro pharmaceutical Co., ltd.), metoprolol succinate tablets (Ashikan pharmaceutical Co., ltd.), and physiological saline (Sichuan Korea pharmaceutical Co., ltd.).
Experimental animals and groups
The experimental group of SPF-grade Balb/c mice with age of 8 weeks were purchased from animal experiment centers in Guangdong province, 120 mice were divided into 8 groups, 15 mice each, 1 blank control group, 2 model group, 3 salvianolic acid B (200 mg/kg) group, 4 Panax notoginseng saponins (60 mg/kg) group, 5 salvianolic acid B+Panax notoginseng saponins (200 mg/kg+60 mg/kg), 6. Sha Kuba trovaptan group (60 mg/kg), 7 digoxin group (oral 0.1 mg/kg), and 8 metoprolol succinate (oral 20 mg/kg) group.
Experimental equipment
Ultrapure water machine (Feidi biotechnology Co., guangzhou), electronic balance (Germany BP 2215), high resolution small animal ultrasonic imaging system (visual Sonics Co., canada).
Experimental method
4.1 Preparation of a model of heart disease in mice lung cancer
SPF-class Balb/C mice are fed in an SPF-class environment with the temperature of 20-26 ℃ and the relative humidity of 40-70% and the brightness alternating for 12/12 hours, and can drink and ingest freely. The urapidan solution (physiological saline as solvent) and the benzopyrene solution (corn oil as solvent) were administered by intraperitoneal injection at a dose of 1 g/kg, 1 time per week for 4 weeks, and the benzopyrene solution was infused (i.g., 2 times per week for 8 weeks at a dose of 50 mg/kg). Control mice were given equal amounts of saline and corn oil in the same manner and time. The number of lung tumors was counted 10 weeks after administration, the lung tumor size was measured and the heart function was examined to evaluate whether the lung cancer heart disease mouse model was successfully constructed. Research evidence shows that the modeling success rate of the method is 100%.
Administration of drugs
The administration of the medicines comprises that a salvianolic acid B (200 mg/kg) group, a Panax notoginsenosides (60 mg/kg) group, a salvianolic acid B+Panax notoginsenosides group (200 mg/kg+60 mg/kg) group, a corresponding dosage of medicines are continuously administered by gastric lavage after the last administration of urapidan, a positive medicine group, a Sha Kuba troxartan group, a digoxin tablet, and a metoprolol succinate group, wherein the dosage of the medicines is 60mg/kg after the last administration of urapidan, the dosage of the digoxin tablet is 0.1mg/kg after the last administration of urapidan, and the dosage of the metoprolol succinate tablet is 20 mg/kg after the last administration of urapidan.
Mice in the blank group and the model group were subjected to gastric lavage with an equal volume of physiological saline and continuous gastric lavage administration was performed for 10 weeks.
After the end of the administration, 10 subsequent experiments were performed per group.
Echocardiography detects changes in cardiovascular function in mice:
The cardiovascular function of mice was measured with a model Vevo3100 high resolution small animal ultrasound imaging system manufactured by visual sonic company, canada. After the mice were anesthetized with 1% isoflurane, the hairs in front of the chest of the mice were removed, and the chest of the mice was applied with an ultrasonic couplant, and the right heart function (right heart free wall thickness (RVWT), right end diastole inner diameter (RVID; d), right Ventricular Stroke Volume (RVSV), right cardiac output (RVCO), and left heart function (left ventricular Ejection Fraction (EF), left ventricular short axis shortening rate (FS), left ventricular end systole inner diameter (LVID; s), left cardiac stroke volume (LVSV), left cardiac output (LVCO)) of the mice were examined.
Calculation of tumor number and volume in mouse lung tissue:
immediately after the end of the cardiac function test, each group of mice was sacrificed, the whole lung tissue was isolated, and the number of tumors (lung cancer tumor node number) and tumor volume in the lung tissue were detected.
Data processing
All data were statistically analyzed using SPSS 24.0. Data are expressed in mean+ -SD, t-test analysis is adopted between two groups of data, ANOVA single-factor analysis of variance is adopted between each group, and P is less than or equal to 0.05, so that significant difference is considered.
Study of technical routes:
See in particular fig. 1.
Experimental results:
4.7.1 influence of Danshen root and Notoginseng radix monomer components on left heart function of mice with heart disease caused by lung cancer
The results are shown in Table 1, after model injection of Ulatin+benzopyrene, the left heart function of the mice in the model group is obviously damaged, the left ventricular ejection fraction (EF%) and the left ventricular short axis shortening rate (FS%) are obviously reduced (P < 0.01), the left ventricular end-systole inner diameter (LVID; s) (P < 0.01) and the left cardiac output (LVCO) are obviously increased (P < 0.05), the left heart function of the mice is improved after treatment by salvianolic acid B, total arasaponin, salvianolic acid B+total arasaponin and Sha Kuba triptan respectively, the left heart function of the mice is obviously increased (P < 0.01), the left ventricular end-systole inner diameter (LVID; s) (P < 0.01) and the left cardiac output (LVCO) (P < 0.05) are obviously reduced, and the treatment effect of the salvianolic acid B+total arasaponin is superior to that of the salvianolic acid B and total arasaponin groups which are independently administered. The evidence shows that the salvianolic acid B and the panax notoginseng saponins can improve the left heart function of mice with lung cancer heart diseases, and the combined administration effect is better.
TABLE 1 left heart function of mice
| Group of | Left ventricular ejection fraction (EF%) | Short axis shortening of left ventricle (FS%) | Left ventricular end systole inner diameter (mm) (LVID; s) | Left heart beat volume (LV SV) | Left cardiac output (ml/min) (LV CO) |
| Blank control group | 83.34±4.06 | 61.87±4.99 | 1.40±0.11 | 32.24±1.06 | 13.14±1.10 |
| Model group | 66.72±5.39** | 42.69±6.27** | 2.16±0.15** | 34.16±1.78 | 15.51±0.70* |
| Salvianolic acid B group | 74.48±7.89## | 53.55±5.67## | 1.81±0.27## | 32.93±1.88 | 14.33±0.84# |
| Notoginseng radix total saponins group | 75.19±7.40## | 53.69±6.02## | 1.56±0.16## | 33.08±1.46 | 14.31±0.99# |
| Salvianolic acid B+Notoginseng radix total saponins group | 77.78±4.21## | 55.49±4.51## | 1.54±0.20## | 32.89±1.52 | 14.22±1.17# |
| Sha Kuba Trifloptan group | 77.89±4.95## | 55.09±6.33## | 1.54±0.20## | 32.88±1.62 | 14.21±1.12# |
| Digoxin group | 63.37±4.53 | 40.95±3.99 | 2.14±0.18 | 34.25±1.57 | 15.37±0.86 |
| Metoprolol group | 65.87±6.18 | 43.11±4.15 | 2.02±0.31 | 34.00±1.19 | 14.98±0.93 |
Note that ** P <0.01 was compared to the placebo group and ## P <0.01 was compared to the model group.
Influence of monomer components of radix Salviae Miltiorrhizae and radix Notoginseng on right heart function of mice with heart disease caused by lung cancer
The results are shown in Table 2, the right heart function of the mice in the model group was significantly impaired after model building with Ulatin+benzopyrene, in terms of right heart free wall thickness (RVWT) (P < 0.05), right end diastole inner diameter (RVID; d), right ventricular pacing (RVSV) (P < 0.05) and right cardiac output (RVCO) were significantly increased (P < 0.01), and the right heart function of the mice was significantly decreased (P < 0.05) after treatment with salvianolic acid B, total saponins of Panax notoginseng, sha Kuba triptan, respectively, in terms of right heart free wall thickness (RVWT) (P < 0.05), right end diastole inner diameter (RVID; d) (P < 0.01), right ventricular pacing (RVSV) (P < 0.05) and right cardiac output (RVCO). And the treatment effect of the salvianolic acid B plus the total arasaponin is better than that of the single administration of the salvianolic acid B and the total arasaponin. The evidence shows that the salvianolic acid B and the panax notoginseng saponins can improve the right heart function of mice with lung cancer heart diseases, and the combined administration effect is better.
TABLE 2 Right heart function of mice
| Group of | Right heart free wall thickness (mm) (RVWT) | Right end diastole inner diameter (mm) (RVID; d) | Right ventricular stroke volume (RV SV) | Right cardiac output (ml/min) (RV CO) |
| Blank control group | 0.6±0.035 | 3.07±0.14 | 29.70±1.22 | 13.10±1.12 |
| Model group | 0.664±0.048* | 3.52±0.09** | 31.94±2.36* | 14.86±1.50** |
| Salvianolic acid B group | 0.604±0.055# | 3.29±0.16## | 30.01±1.21# | 13.44±1.35# |
| Notoginseng radix total saponins group | 0.603±0.051# | 3.27±0.17## | 29.85±1.21# | 13.39±1.06# |
| Salvianolic acid B+Notoginseng radix total saponins group | 0.599±0.058# | 3.12±0.20## | 29.93±1.19# | 13.26±0.72# |
| Sha Kuba Trifloptan group | 0.601±0.035# | 3.14±0.17## | 29.86±1.20# | 13.23±1.14# |
| Digoxin group | 0.652±0.059 | 3.54±0.11 | 32.49±2.18 | 15.03±1.02 |
| Metoprolol group | 0.646±0.036 | 3.49±0.45 | 31.76±1.93 | 14.92±1.31 |
Note that *P＜0.05,** P <0.01 was compared to the placebo group and #P＜0.05,## P <0.01 was compared to the model group.
Influence of monomer components of red sage root and notoginseng on lung cancer heart disease mouse tumor
The results are shown in Table 3, and after modeling with Ulatan+benzopyrene, a large number of tumors (P < 0.01) can be detected in lung tissues of mice in the model group, which suggests that the lung cancer heart disease model is successfully constructed. After treatment with salvianolic acid B, panax notoginsenosides, sha Kuba troxartan, digoxin and metoprolol succinate, the number of tumors and the volume of tumors in the lung tissue of the mice are not obviously changed (P > 0.05), and the result indicates that the salvianolic acid B, the Panax notoginsenosides, sha Kuba troxartan, digoxin and metoprolol succinate have no effect on the treatment of lung cancer.
TABLE 3 number of tumors and tumor volumes in mouse lung tissue
| Group of | Number of tumors | Tumor volume (mm) |
| Blank control group | 0.00±0.00 | 0.00±0.00 |
| Model group | 6.6±1.07** | 1.54±0.42** |
| Salvianolic acid B group | 6.7±1.88 | 1.56±0.27 |
| Notoginseng radix total saponins group | 6.8±2.10 | 1.54±0.31 |
| Salvianolic acid B+Notoginseng radix total saponins group | 6.3±1.34 | 1.59±0.22 |
| Sha Kuba Trifloptan group | 6.4±1.07 | 1.51±0.44 |
| Digoxin group | 6.5±1.51 | 1.50±0.28 |
| Metoprolol group | 6.7±1.34 | 1.52±0.32 |
Note that ** P <0.01 was compared to the placebo group.
The results highly suggest that the salvianolic acid B and the panax notoginseng saponins can improve the heart function of mice with lung cancer heart disease, have better combined use effect, have no treatment effect on lung cancer, and mainly play a role in improving the heart function of the mice with lung cancer heart disease through the cardioprotection effect.
5. Discussion of the invention
With the progress of lung cancer, the human body can suffer from organ failure with different degrees, wherein heart injury is the most clinically concerned problem, namely, the heart is injured in the occurrence and development process of the lung cancer, serious arrhythmia and abnormal electrophysiological conduction of the heart are caused, the heart is enlarged, and finally heart failure is caused. Heart failure can cause the patient to feel hypoxia, chest distress, suffocation and dyspnea, and lung cancer itself can also cause reduced respiratory function. If the disease progress of heart failure caused by lung cancer is not controlled, chest water is generated, large-volume lung is occupied, ventilation is influenced, dyspnea is serious, and then respiratory failure is developed, so that if heart failure occurs to a patient suffering from lung cancer and heart disease, the condition usually means that the condition enters the final stage, the survival period is greatly shortened, the salvianolic acid B is combined with the panax notoginseng saponins, by increasing the left ventricular ejection fraction and the left ventricular short axis shortening rate, the inner diameter of the end systole of the left ventricle and the left cardiac output are reduced, and the thickness of the free wall of the right heart, the inner diameter of the end diastole of the right heart, the stroke volume of the right ventricle and the right cardiac output are reduced, so that the heart function of the lung cancer heart disease is improved, the effect of preventing and treating heart failure is achieved, and the effect is equivalent to that of the sakuba-trovaptan commonly used clinically at present. Early experiments also show that the effect of improving cardiac function can be achieved by proportionally and jointly reducing half dose, so that the salvianolic acid B and the total saponins of pseudo-ginseng are jointly applied to preventing and treating lung cancer heart diseases, and the method has clinical popularization and application prospects.
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