CN117805358A

CN117805358A - Sample analyzer and liquid injection control method

Info

Publication number: CN117805358A
Application number: CN202211174653.2A
Authority: CN
Inventors: 张云飞; 孙娟娟; 鞠文涛
Original assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Current assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Priority date: 2022-09-26
Filing date: 2022-09-26
Publication date: 2024-04-02

Abstract

The embodiment of the application provides a sample analyzer and a liquid injection control method, wherein the sample analyzer comprises: the reaction device is provided with at least one reaction site and is used for incubating a reaction liquid in the reaction cup at the reaction site; the magnetic separation device comprises a magnetic separation component and a liquid injection component, wherein the magnetic separation component is provided with a magnetic separation position and is used for magnetically separating reaction liquid in a reaction cup arranged in the magnetic separation position, and the liquid injection component is used for injecting cleaning liquid into the reaction cup in the magnetic separation position; control means for: and before the liquid injection assembly injects the cleaning liquid into the reaction cup positioned in the magnetic separation position, controlling the liquid injection assembly to at least drain the cleaning liquid positioned in the liquid injection assembly. The sample analyzer provided by the application can improve the magnetic separation cleaning effect of the magnetic separation device, and further improve the precision of sample analysis results.

Description

Sample analyzer and liquid injection control method

Technical Field

The application relates to the technical field of medical instruments, in particular to a sample analyzer and a liquid injection control method.

Background

The sample analyzer is exemplified by an immunoassay analyzer, which is a type of high-sensitivity and high-specificity analyzer commonly used in clinical laboratories to detect various immune indexes of blood, urine or other body fluids. The principle is to combine the two technologies of antibody antigen reaction and chemiluminescence, so as to achieve high specificity and high sensitivity.

The main operation flow in the immunity analyzer comprises a magnetic separation cleaning flow, wherein the magnetic separation cleaning flow uses the surface of small particles with magnetic materials to adsorb required substances through a certain treatment, then the magnetic separation cleaning flow uses a magnet to adsorb and enrich the substances, then the waste liquid is discarded, and the liquid injection assembly is used for injecting liquid to clean the enriched magnetic beads so as to remove impurities and other unnecessary substances, so that the biological substances of interest are retained due to the adsorption on the magnetic beads.

However, in the magnetic separation cleaning process, the temperature of the cleaning liquid output by the liquid injection assembly and the amount of the cleaning liquid may affect the accuracy of the final sample detection.

Disclosure of Invention

The embodiment of the application mainly aims at providing a sample analyzer and a liquid injection control method, and aims at improving the accuracy of sample detection.

In a first aspect, embodiments of the present application provide a sample analyzer, comprising:

the reaction device is provided with at least one reaction site and is used for incubating a reaction liquid in the reaction cup at the reaction site;

the magnetic separation device comprises a magnetic separation component and a liquid injection component, wherein the magnetic separation component is provided with a magnetic separation position and is used for magnetically separating reaction liquid in a reaction cup arranged in the magnetic separation position, and the liquid injection component is used for injecting cleaning liquid into the reaction cup in the magnetic separation position;

control means for:

and before the liquid injection assembly injects the cleaning liquid into the reaction cup positioned in the magnetic separation position, controlling the liquid injection assembly to at least drain the cleaning liquid positioned in the liquid injection assembly.

In a second aspect, embodiments of the present application further provide a method for controlling liquid injection, applied to a sample analyzer, the method including: before a liquid injection component of the sample analyzer injects cleaning liquid into a reaction cup to be subjected to magnetic separation cleaning in a magnetic separation position of a magnetic separation device of the sample analyzer, controlling the liquid injection component to at least drain the cleaning liquid in the liquid injection component.

The embodiment of the application provides a sample analyzer and a liquid injection control method, in an implementation manner, the sample analyzer comprises: the reaction device is provided with at least one reaction site and is used for incubating a reaction liquid in the reaction cup at the reaction site; the magnetic separation device comprises a magnetic separation component and a liquid injection component, wherein the magnetic separation component is provided with a magnetic separation position and is used for magnetically separating reaction liquid in a reaction cup arranged in the magnetic separation position, and the liquid injection component is used for injecting cleaning liquid into the reaction cup in the magnetic separation position; control means for: and before the liquid injection assembly injects the cleaning liquid into the reaction cup positioned in the magnetic separation position, controlling the liquid injection assembly to at least drain the cleaning liquid positioned in the liquid injection assembly.

Based on the fact that the cleaning liquid in the liquid injection component of the sample analyzer is easily affected by the environment, the temperature of the cleaning liquid in the liquid injection component is lower than the preset temperature, or the amount of the cleaning liquid in the liquid injection component is reduced due to the fact that the cleaning liquid in the liquid injection component is evaporated or volatilized in the air, if the magnetic separation cleaning is performed by using the cleaning liquid in the liquid injection component at the moment, the accuracy of a sample analysis result can be affected due to the fact that the liquid discharge amount of the cleaning liquid is insufficient or the temperature of the cleaning liquid is low. Based on this, this embodiment of the application is through before annotating the liquid subassembly of sample analysis appearance and pour into the washing liquid into the reaction cup that is arranged in the magnetic separation position into, control annotate the liquid subassembly and carry out the flowing back to the washing liquid that is arranged in annotating the liquid subassembly at least to discharge the washing liquid that the temperature is lower, and supplied annotate the washing liquid that reduces because volatilize or evaporation in the liquid subassembly, improve magnetic separation cleaning effect of magnetic separation device, and then promote the precision of sample analysis result.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the disclosure of embodiments of the present application.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings needed in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are some embodiments of the present application, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

FIG. 1 is a block diagram of components of a sample analyzer in one embodiment;

FIG. 2 is a schematic diagram of components of a sample analyzer in one embodiment;

FIG. 3 is a schematic diagram of components of a dispensing device of a sample analyzer in one embodiment;

FIG. 4 is a schematic diagram of the schematic components of a magnetic separation device of a sample analyzer in one embodiment;

FIG. 5 is a schematic diagram of the fluid circuit structure of the fluid injection assembly of the magnetic separation device according to one embodiment;

FIG. 6 is a test schematic of an immunoassay;

FIG. 7A is a schematic diagram illustrating the timing relationship of the sample detection period T according to one embodiment;

FIG. 7B is a schematic diagram showing parallel operation timing relationship of a plurality of sample detection periods T according to another embodiment;

FIGS. 7C and 7D are schematic diagrams of the timing relationship of the addition of the empty cup operation flow before the magnetic separation actuation sub-period of the sample detection period T in one embodiment;

FIG. 8A is a timing diagram illustrating the flow of an insert empty cup operation prior to a magnetic separation sub-action cycle of a sample detection cycle in one embodiment;

FIG. 8B is a timing diagram illustrating an insert empty cup operation process prior to a magnetic separation sub-action cycle of a sample detection cycle in another embodiment.

Detailed Description

The following description of the embodiments of the present application will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the described embodiments are some, but not all, examples of the present application. All other embodiments, which can be made by one of ordinary skill in the art without undue burden from the present disclosure, are within the scope of the present disclosure.

In the description of the present application, unless explicitly stated and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the terms in this application will be understood by those of ordinary skill in the art in a specific context.

The flow diagrams depicted in the figures are merely illustrative and not necessarily all of the elements and operations/steps are included or performed in the order described. For example, some operations/steps may be further divided, combined, or partially combined, so that the order of actual execution may be changed according to actual situations.

Some embodiments of the present application will be described in detail below with reference to the accompanying drawings, and the features of the following examples and embodiments may be combined with each other without conflict.

Referring to fig. 1, a sample analyzer 100 is provided for analyzing a sample to be tested to obtain a corresponding analysis result.

In some embodiments, the sample analyzer includes, but is not limited to, at least one of: biochemical analyzer, immunity analyzer, coagulation analyzer, urine analyzer.

As shown in fig. 1, the sample analyzer 100 includes a dispensing device 10, a sample supply device 20, a reagent supply device 30, a reaction device 40, a mixing device 50, a detection device 60, and a controller 70.

The sample supply device 20 is used for providing a sample to be tested, the reagent supply device 30 is used for providing a reagent reacting with the sample, and the reaction device 40 is provided with at least one reaction site for placing a liquid container, wherein the liquid container comprises, but is not limited to, a reaction cup. For convenience of description, in the embodiments of the present application, a liquid container is taken as an example of a reaction cup. The dispensing device 10 is used for injecting a sample supplied from the sample supply device 20 and a reagent supplied from the reagent supply device 30 into a reaction cup so that the sample and the reagent are mixed to form a reaction solution. The sample analyzer is provided with a mixing position, a mixing device 50, and is used for mixing the sample and the reagent placed in the reaction cup of the mixing position, so that the sample and the reagent fully react to form a reaction solution. The detection device 60 is used for detecting the reaction liquid to obtain a corresponding detection result.

Referring to fig. 2-3, in some embodiments, the sample supply 20 may include a sample distribution module (SDM, sample Delivery Module) and a front end rail; the sample supply 20 may also be a sample tray comprising a plurality of sample locations where sample, such as sample tubes, may be placed, the sample tray being capable of dispensing samples to corresponding locations, such as to the point where the sample is aspirated by the dispensing device 10, by rotating its tray assembly. The dispensing device 10 is used to aspirate and discharge a sample into a cuvette 4011 to be loaded.

In some embodiments, the dispensing device 10 includes a sample dispensing device 10a, wherein the sample dispensing device 10a is configured to aspirate a sample supplied by the sample supply device 20 and transfer the sample to a predetermined location, e.g., the sample dispensing device 10a aspirates the sample from the sample supply device 20 and discharges the sample to the cuvette 4011 to be loaded.

The sample dispensing device 10a includes a sample needle 101, a first driving unit 102, and a first pipetting driving unit 103, where the first driving unit 102 is configured to support the sample needle 101 and drive the sample needle 101 to move. For example, the sample needle 101 is spatially moved in two or three dimensions by a two or three dimensional first drive assembly 102 so that the sample needle 101 can be moved to aspirate a sample carried by the sample supply 20.

The first pipetting driving unit 103 is configured to quantitatively aspirate a sample, for example, a blood sample to be measured by the sample needle 101, wherein the sample needle 101 is driven by the first driving component 102 to move into a sample tube loaded with the blood sample on the sample supplying device 20, aspirate the blood sample to be measured by the driving of the first pipetting driving unit 103, and convey the blood sample to be measured into the reaction cup 4011 of the reaction device 40, so that the blood sample to be measured aspirated by the dispensing device 10 and a reagent provided by the reagent supplying device 20 are mixed in the reaction cup 4011 to prepare a sample to be measured.

As shown in fig. 3, in some embodiments, the first driving assembly 102 includes a support frame 1021, the support frame 1021 is fixed on the support rod 1022, the support rod 1022 can move vertically and rotate, and the support frame 1021 is driven by the support rod 1022 to realize vertical movement and horizontal rotation. The sample needle 101 is disposed on the support 1021, and driven by the support 1021, can reach a target position. The first drive assembly 102 also includes a driver 1023 for driving the movement of the support pole 1022, such as, but not limited to, a stepper motor. Alternatively, the sample needle 101 may be detachably connected to the first drive assembly 102, or may be fixedly connected.

In some embodiments, the first pipetting drive unit 103 includes a line 1031 and a power assembly 1033, wherein the line 1031 is used for transporting the fluid medium, one end of the line 1031 is communicated with the sample needle 101, and the other end is communicated with the power assembly 1033, so that the flow direction of the fluid medium in the line 1031 is changed under the action of the power assembly 1033, so that the sample needle 101 can transfer the sample.

In some embodiments, the dispensing device 10 includes a reagent dispensing device 10b, the reagent supplying device 30 includes a reagent carrying member 301 for carrying a reagent, and the reagent dispensing device 10b of the dispensing device 10 sucks the reagent carried by the reagent supplying device 30 and supplies the reagent to the reaction device 40, wherein the reagent includes but is not limited to a chromogenic reagent, a diluent, a substrate solution, an enzyme-labeled reagent, and the like.

In some embodiments, the reagent carrier 301 may be a reagent disk, which is provided as a disk-shaped assembly having a plurality of positions for carrying reagent containers, and the reagent carrier 301 is capable of rotating and driving the reagent containers carried thereby to rotate the reagent containers to a specific position, such as a position where reagent is sucked by the reagent dispensing device 10 b. Wherein the number of reagent carrying members 301 may be one or more.

In some embodiments, the reagent dispensing device 10b may include a reagent needle, a second drive assembly, and a second pipetting drive unit. The reagent needle performs a two-dimensional or three-dimensional motion in space by the two-dimensional or three-dimensional second driving assembly, so that the reagent needle can move and cooperate with the second pipetting drive part to suck the reagent carried by the reagent carrying member 301 and move to the cuvette 4011 to be filled with the reagent and discharge the reagent to the cuvette 4011.

In some embodiments, the second driving component and the first driving component 102 have the same structure, and are not described herein.

In some embodiments, the second pipetting driving unit and the first pipetting driving unit 103 have the same structure, and are not described here.

In some embodiments, the reagent dispensing device 10b does not add reagent by means of a reagent needle, but adds reagent in a reagent tube to the cuvette 4011 by means of a dedicated line. In such embodiments, only sample needle 101 is provided, without a reagent needle.

It will be appreciated that depending on the body fluid to be tested and the item to be tested, the sample and reagent may be added in different ways, for example, both the sample and reagent may be added using the sample needle 101, or the sample may be added using the sample needle 101, the reagent may be added using the reagent needle, or only the sample may be added using the sample needle 101, or the reagent may be added using other means. That is, the sample dispensing device 10a of the dispensing device 10 is used for both transferring a sample and transferring a reagent; or the sample dispensing device 10a of the dispensing device 10 is used for transferring a sample, and the reagent dispensing device 10b is used for transferring a reagent; or the sample dispensing device 10a of the dispensing device 10 is used for transferring a sample, and the reagent is connected to a reagent container for holding the reagent through a dedicated line so as to be added to the cuvette 4011. Thus, the sample needle 101 and/or the reagent needle are also referred to as pipetting needle, i.e. the pipetting needle comprises at least either of the sample needle 101 and the reagent needle.

In some embodiments, the reaction device 40 has a support 401, and the support 401 is provided with at least one reaction site for placing a reaction cup 4011, the reaction cup 4011 is for receiving a sample supplied by the sample supply device 20 and a reagent supplied by the reagent supply device 30 and providing a reaction site for the sample and the reagent to mix to form a reaction liquid, and the reaction device 40 is also for incubating the reaction liquid within the reaction cup 4011.

For example, the support portion 401 of the reaction device 40 may be a reaction disk, as shown in fig. 2, which is configured as a disk-shaped component, and has one or more reaction sites for placing reaction cups 4011, where the reaction disk may incubate the reaction liquid in the reaction cups 4011 and can rotate to drive the reaction cups 4011 placed in the reaction sites to rotate, so as to implement the dispatching of the reaction cups 4011 in a preset area in the reaction disk.

It will be appreciated that the reaction sites for the reaction cups may be provided not only on the reaction tray of the reaction apparatus 40 but also independently of the reaction tray of the reaction apparatus 40. The arrangement of the reaction sites independently of the reaction plate means that the arrangement of the reaction sites does not interfere with the rotation of the reaction plate itself. Alternatively, when the mixing device 50 does not perform the mixing operation, the mixing bits are multiplexed as temporary storage bits of the cuvette 4011.

In some embodiments, the detection device 60 is used for measuring the reaction liquid in the reaction cup or the sample to be tested incubated by the reaction liquid, so as to obtain the reaction data of the sample. For example, the detection device 60 includes a photometry mechanism for detecting the luminous intensity of a sample to be measured, and calculates the concentration of the component to be measured in the sample, etc. by a calibration curve. Alternatively, the detecting device 60 is separately provided on the peripheral side of the reaction device 40.

In further embodiments, the detection device 60 includes an electrical detection mechanism (e.g., an impedance measurement mechanism) or other principle detection mechanism (e.g., an imaging measurement mechanism).

In some embodiments, the sample analyzer further includes a dispatching device (not shown) for performing dispatching of the reaction cup, specifically, the dispatching device may grab the target object and drive the target object to move in a two-dimensional or three-dimensional space, so as to implement dispatching of the target object. For example, the scheduler may schedule the cuvette 4011 to a sample site in the sample analyzer so that the sample dispensing device 10a performs a sample filling operation on the cuvette 4011 placed in the sample site, or may schedule the cuvette 4011 to a reagent site in the sample analyzer so that the reagent dispensing device 10b performs a reagent filling operation on the cuvette 4011 placed in the reagent site, or may schedule the cuvette 4011 filled with the sample and the reagent to a mixing site of the mixing device 50 so that the solution in the cuvette 4011 is mixed at the mixing site, or may schedule the cuvette 4011 having completed the mixing operation on the mixing site of the mixing device 50 to the reaction device 40 for incubation.

In some embodiments, the sample analyzer 100 further includes a magnetic separation device 80 for performing magnetic separation and cleaning on the reaction solution, so as to extract the magnetic particles enriched with the analyte in the reaction solution, and clean impurities attached to the surface of the magnetic particles, so as to improve the purity of the analyte in the sample to be detected, and further improve the accuracy of the sample detection result.

Referring to FIG. 4, magnetic separation device 80 illustratively includes a magnetic separation assembly 801, a priming assembly 802. The magnetic separation unit 801 is provided with a magnetic separation site and is used for magnetically separating a reaction liquid in the reaction cup 4011 placed in the magnetic separation site, and the liquid injection unit 802 is used for injecting a cleaning liquid into the reaction cup 4011 in the magnetic separation site.

Optionally, the magnetic separation device 80 comprises a wicking assembly 803 for wicking waste liquid generated by the magnetic separation device 80 during performance of the magnetic separation.

Specifically, the magnetic separation module 801 includes a magnetic separation disk 8011 and an adsorption module 8012. The magnetic separation disk 8011 is provided with at least one magnetic separation position, and the magnetic separation disk 8011 is of a rotatable structure and is provided with at least one filling level and at least one sucking level along the rotation path thereof; the adsorption component 8012 is provided with at least one magnetic adsorption component capable of adsorbing magnetic particles in the reaction liquid in the reaction cup at the magnetic separation position; the liquid injection assembly 802 is used for injecting a cleaning liquid into the reaction cup 4011 which moves to the liquid injection level so as to clean impurities attached to the surface of the magnetic particles; the pipetting assembly 803 is used to perform pipetting operations on the cuvette 4011 moved to the pipetting position.

For example, after the magnetic separation device 80 receives the cuvette 4011, the cuvette 4011 is subjected to N-order magnetic separation cleaning, where N is an integer greater than or equal to 1; for any one order of magnetic separation cleaning, it includes: after the reaction cup 4011 reaches the filling level, the filling component 802 adds a cleaning liquid into the reaction cup 4011, performs magnetic separation cleaning on the reaction liquid in the reaction cup 4011, transfers the reaction cup 4011 after the magnetic separation cleaning to a liquid suction position, and performs liquid suction on the reaction cup 4011 through the liquid suction component 803 to complete the magnetic separation cleaning of the first stage, and circulates in this way until the reaction cup 4011 after the magnetic separation cleaning of the N-stage waits for dispatching out the magnetic separation disk 8011 of the magnetic separation device 80.

In some embodiments, the magnetic separation device 80 further comprises a substrate injection assembly 804 for adding substrate to the cuvette 4011 undergoing magnetic separation cleaning, e.g., the substrate injection assembly 804 injects substrate into the cuvette 4011 after the pipetting assembly 803 has performed an N-up pipetting operation on the cuvette 4011 at the pipetting level.

Illustratively, after the reaction cup 4011 carrying the reaction solution formed by mixing the sample and the reagent is transferred to the reaction device 40, the reaction device 40 incubates the sample and the reagent in the reaction cup 4011, the incubated reaction cup 4011 is transferred to the magnetic separation device 80 for magnetic separation and cleaning, the reaction cup 4011 after the magnetic separation and cleaning is injected with the substrate and transferred to the reaction device 40 for incubation, and the incubated reaction cup 4011 is transferred to the corresponding photometric position to enable the detection device 60 to perform luminescence detection on the object to be detected, so as to obtain the corresponding parameters of the sample. The transfer of cuvette 4011 may be performed by a scheduler within sample analyzer 100.

To facilitate understanding of the sample and reagent stage names, the sample and reagent stage names are described in detail herein: the sample in the cuvette 4011 is mixed with the reagent and then referred to as a mixture, also referred to as a reaction solution, and the reaction device 40 is capable of incubating the mixture in the cuvette 4011 to allow the sample to react with the reagent sufficiently to obtain a sample to be tested, and at this time, the sample to be tested in the cuvette 4011 is an object to be tested and impurities. The mixture is a substance formed by mixing a sample with a reagent, and is referred to as a mixture herein regardless of the ratio or concentration of the sample to the reagent. The incubated mixture is presented as the analyte and impurities in the cuvette 4011. The impurities may be insufficiently reacted substances, side reaction products generated by side reactions, other substances affecting the detection by the detection device 60, or the like, or a combination of at least two of the above. The magnetic separator 80 cleans the sample and impurities in the cuvette 4011 to remove the impurities in the cuvette 4011 and retain the sample in the cuvette 4011. The detection device 60 can detect the object to be detected in the reaction cup 4011 to obtain various parameters of the sample. When a substrate is added to the cuvette 4011 after separation and washing, the substrate is mixed with the sample in the cuvette 4011, and the substrate does not change the property of the sample, but only increases the luminescence value of the sample, so that the substrate is still called the sample after being mixed with the sample.

Referring to fig. 5, in some embodiments, a fill assembly 802 is provided with a fill port 8020 and is used to perform a fill of a target device, including but not limited to a reaction cup, through the fill port 8020.

Specifically, the priming assembly 802 includes a priming line 8022, a reservoir 8023, a power assembly 8024, and a temperature control assembly 8025, wherein the target devices include, but are not limited to, a cuvette and a wash bowl of a wash apparatus of a sample analyzer. The liquid storage container 8023 is used for storing liquid (such as cleaning liquid), the temperature control component 8025 is communicated between the liquid injection port 8020 and the liquid storage container 8023, the power component 8024 is communicated with the liquid injection port 8020 through a liquid injection pipeline 8022 and is used for providing power for the liquid to flow in the liquid injection pipeline 8022, and the temperature control component 8025 is at least used for adjusting the temperature of the liquid flowing through the liquid injection pipeline 8022.

It can be appreciated that the temperature control component 8025 is provided with a liquid circulation component which is communicated with the liquid injection pipeline 8022, and a preheating component which is used for preheating the liquid circulated in the liquid circulation component, wherein the liquid circulation component can be integrally formed with the liquid injection pipeline 8022, can be respectively and independently formed with the liquid injection pipeline 8022 and then connected through a connecting piece or through welding, gluing and other modes, and can be used for directly heating the liquid circulation component, can also be used for heating the heat-conducting medium, and can be used for indirectly heating the liquid circulation component through the heat-conducting medium.

For example, the liquid filling pipe 8022 and the liquid circulation component are integrally formed, the liquid circulation component is wound around the heat conducting medium, and the preset component of the temperature control assembly 8025 heats the heat conducting medium, so that the heat conducting medium is used to heat the liquid in the liquid circulation component. The temperature of the liquid in the liquid circulation member may be collected by a temperature sensor, for example, a temperature sensor is provided on an outer wall of the liquid circulation member to collect the temperature of the liquid in the liquid circulation member.

In some embodiments, the power assembly 8024 is connected to the liquid storage container 8023 and the temperature control assembly 8025 through a pipeline, and the power assembly 8024 comprises a switch unit arranged on the pipeline and used for controlling the on-off of the pipeline and a power unit used for driving the cleaning liquid to flow in a preset direction in the pipeline. The control device 70 is communicatively coupled to a switch unit including, but not limited to, a solenoid valve and/or a throttle valve, and a power unit including, but not limited to, a pump, a syringe, to control the power unit to provide cleaning fluid to the cuvette 4011 through the fluid inlet 8020 when fluid is being injected into a target device (e.g., the cuvette 4011).

In some embodiments, the infusion assembly 802 further includes an infusion needle 8021 in communication with the infusion line 8022, and the infusion port 8020 is disposed at an end of the infusion needle 8021, the infusion assembly 802 performing infusion through the infusion needle 8021 to a target device. Alternatively, the port of the priming line 8022 is used as the priming port 8020, and priming is directly performed to the target device through the priming line 8022.

The controller 70 is communicatively connected to the dispensing device 10, the sample supply device 20, the reagent supply device 30, the reaction device 40, the mixing device 50, the magnetic separation device 80, and the detection device 60, so that at least one of the dispensing device 10, the sample supply device 20, the reagent supply device 30, the reaction device 40, the mixing device 50, the magnetic separation device 80, and the detection device 60 can perform a predetermined operation, such as performing a mixing operation of the sample, a magnetic separation washing operation of the sample, or a detection operation of the sample.

In some embodiments, the controller 70 includes at least a processor 701, a memory 702, a communication interface (not shown), and an I/O interface (not shown). The processor 701, memory 702, communication interfaces, and I/O interfaces communicate over a bus. The processor 701 may be a central processing unit (Central Processing Unit, CPU) which may also be other general purpose processors, digital signal processors (Digital Signal Processor, DSP), application specific integrated circuits (Application Specific Integrated Circuit, ASIC), field-programmable gate arrays (Field-Programmable Gate Array, FPGA) or other programmable logic devices, discrete gate or transistor logic devices, discrete hardware components, or the like. Wherein the general purpose processor may be a microprocessor or the processor may be any conventional processor or the like.

Various computer programs to be executed by the processor 701, such as an operating system and application programs, are stored in the memory 702, and data necessary for executing the computer programs. During analysis of the sample under test, data stored locally, if needed, may be stored in memory 702. The I/O interface includes, but is not limited to, serial interfaces such as USB, IEEE1394, or RS-232C, parallel interfaces such as SCSI, IDE, or IEEE1284, and analog signal interfaces composed of D/a converters, and the like. An input assembly is coupled to the I/O interface and a user may directly input data to the controller 70 using the input assembly, including but not limited to a keyboard, mouse, touch screen, or control buttons. The display assembly may be communicatively coupled to the controller 70 via an I/O interface for relevant information prompting. The communication interface may be an interface of any communication protocol known at present, the communication interface communicates with the outside through a network, and the controller 70 may transmit data with any component connected through the network through the communication interface in a preset communication protocol.

In some embodiments, the controller 70 is configured to at least: the liquid injection unit 802 of the magnetic separation device 80 is controlled to drain at least the cleaning liquid in the liquid injection unit 802 before the cleaning liquid is injected into the cuvette 4011 in the magnetic separation position.

Illustratively, a sample analyzer is taken as an immunoassay analyzer, which is a type of high-sensitivity and high-specificity analyzer commonly used in clinical laboratories to detect various analysis indexes of blood, urine or other body fluids. Conventional immunoassays have various implementation principles such as chemiluminescence, electrochemiluminescence, etc.

Referring to fig. 6, taking a chemiluminescent immunoassay analyzer as an example, the main working principle is as follows: when it is desired to measure a component in a sample, the corresponding antibody/antigen may be coated on a magnetic bead to form a magnetic bead reagent, and a specific label may be labeled on the antibody to form a labeled reagent (the reagent for measuring an analyte item generally has various components, such as a magnetic bead reagent component, a labeled reagent component, etc., herein, and different components of the same item may be packaged in different reagent containers or different chambers of the same reagent container). Firstly, mixing a sample containing an object to be tested with a magnetic bead reagent, a labeling reagent and other reagents to form a sample reagent reaction solution (simply referred to as reaction solution), and incubating under certain conditions to react to form a mixture, wherein the mixture comprises the object to be tested and impurities, and then removing the impurities (such as unbound labeling substance, other reagents and samples) in the mixture by a washing separation (generally abbreviated as B/F) technology; then adding a signal reagent (also called a substrate) into the sample, enabling the marker on the sample to react with the signal reagent (or catalyze the signal reagent) to emit light, detecting the luminous intensity of the sample, and calculating the concentration of the sample component in the sample by using a calibration curve. Wherein the signal reagent can be one or more of luminescent substrate liquid, pre-excitation liquid, luminescence enhancing liquid, etc.

In the process of detecting a sample to be detected by the sample analyzer, the magnetic separation device 80 is used for performing magnetic separation cleaning on the reaction liquid in the reaction cup 4011, wherein the magnetic separation component 801 of the magnetic separation device 80 is used for performing magnetic separation on the reaction cup 4011 carrying the reaction liquid, and the liquid injection component 802 of the magnetic separation device 80 is used for cleaning the surface of the magnetic particles enriched with the substance to be detected in the reaction liquid in the process of performing magnetic separation on the reaction cup 4011 carrying the reaction liquid by the magnetic separation device 80.

In the magnetic separation process of the magnetic separation device 80, the magnetic particles are magnetically adsorbed and fixed on the wall of the reaction cup 4011 by the adsorption component 8012, and at this time, the cleaning liquid is injected into the reaction cup 4011 through the injection component 802 to clean impurities attached to the surface of the magnetic particles, so that the accuracy of the sample detection result is improved.

Based on the fact that the to-be-detected object in the reaction solution is sensitive to the change of the environmental temperature, in order to ensure the accuracy of the sample detection result, the temperature of the first washing solution injected into the reaction cup 4011 by the liquid injection component 802 must be controlled within a preset temperature range in the process of performing the washing operation, and if the temperature fluctuation of the washing solution is large in the process of performing the washing operation by the magnetic separation device 80, the accuracy of the final sample detection result may be affected.

Before the liquid injection component 802 performs the liquid injection operation on the reaction cup 4011 in the magnetic separation position, the cleaning liquid stored in the liquid injection pipeline 8022 of the liquid injection component 802 is affected by the environment, a certain temperature difference may exist between the temperature of the cleaning liquid and the preset temperature, or the cleaning liquid in the liquid injection component 802 is evaporated or volatilized in the air so that the amount of the cleaning liquid in the liquid injection component 802 is reduced, if the cleaning liquid in the liquid injection component 802 is used for performing the magnetic separation cleaning at this time, the accuracy of the sample analysis result may be affected due to insufficient liquid discharge amount of the cleaning liquid or lower temperature of the cleaning liquid.

Therefore, before the liquid injection component 802 of the sample analyzer 100 injects the cleaning liquid into the reaction cup 4011 located in the magnetic separation position, the liquid injection component 802 is controlled to drain the cleaning liquid at least in the liquid injection component 802, so as to drain the cleaning liquid with a lower temperature, and the cleaning liquid reduced by volatilization or evaporation in the liquid injection component 802 is supplemented, so that when the magnetic separation device 80 performs magnetic separation cleaning, the temperature of the cleaning liquid drained through the liquid injection component 802 and the amount of the cleaning liquid both meet the preset requirements, thereby improving the magnetic separation cleaning effect of the magnetic separation device 80, and further improving the accuracy of sample analysis.

In some embodiments, the controller 70 is further configured to perform: acquiring the current environmental temperature, and if the current environmental temperature is smaller than the preset temperature, controlling the liquid injection component 802 to drain at least the cleaning liquid in the liquid injection component 802 before the liquid injection component 802 injects the cleaning liquid into the reaction cup 4011 to be subjected to magnetic separation cleaning in the magnetic separation position;

or, when the time interval between the two liquid injection operations of the liquid injection assembly 802 is greater than the preset time interval, the liquid injection assembly 802 is controlled to drain the cleaning liquid in the liquid injection assembly 802 between the two liquid injection operations of the liquid injection assembly 802.

For example, if the ambient temperature is lower than a preset temperature, or the time interval between two priming operations performed by the priming member 802 is greater than a preset time interval, the priming member 802 may have the following two conditions:

first, the temperature of the cleaning fluid within the fluid injection assembly 802 is affected by the ambient temperature, resulting in that the temperature of a portion of the cleaning fluid within the fluid injection assembly 802 may not meet a predetermined temperature criterion, e.g., the cleaning fluid in the fluid injection line 8022 is affected by the ambient temperature, and the temperature difference between the cleaning fluid and the predetermined temperature may exceed a predetermined value.

Second, the longer time that the cleaning fluid in the fill assembly 802 can cause the cleaning fluid to evaporate or volatilize, affecting the accuracy of the next fluid discharge. For example, the amount of cleaning fluid in the fill line 8022 may decrease due to evaporation of the cleaning fluid in the fill line 8022, and at this time, if the fill assembly 802 performs a drain, the amount of cleaning fluid that is drained may be less than a preset amount.

Therefore, by controlling the liquid injection component 802 to drain the cleaning liquid located in the liquid injection component 802, the cleaning liquid with a lower temperature in the liquid injection component 802 is drained, and the amount of the cleaning liquid reduced by volatilization is replenished, so that when the liquid injection pipeline 8022 performs liquid injection cleaning on the reaction cup 4011, the accuracy of the amount of the emitted cleaning liquid meets the preset requirement, the temperature of the cleaning liquid is in the preset temperature range, and the accuracy of the sample analysis result is further improved.

For example, after the injection assembly 802 completes the injection operation of the cleaning liquid into the reaction cup 4011 located in the magnetic separation position for the kth time and before the injection operation of the cleaning liquid into the reaction cup 4011 located in the magnetic separation position for the kth time, a first time corresponding to the injection operation of the injection assembly 802 for the kth time into the reaction cup 4011 located in the magnetic separation position and a second time corresponding to the injection assembly 802 for the kth time into the reaction cup 4011 located in the magnetic separation position for the kth time are obtained, and if a time interval between the first time and the second time is greater than a preset time interval, the power assembly 8024 is controlled to perform liquid discharge through the liquid injection port 8011 before the injection assembly 802 performs the injection operation of the cleaning liquid into the reaction cup 4011 located in the magnetic separation position for the kth time and for the kth time is controlled to discharge at least a part of the cleaning liquid in the injection assembly 802.

Alternatively, when the ambient temperature is less than the preset temperature value, the power assembly 8024 is controlled to perform liquid draining through the liquid filling port 8011, so as to drain at least part of the cleaning liquid in the liquid filling assembly 802.

In some embodiments, the sample analyzer 100 further comprises: a dispensing device 10, a detection device 60, a scheduling device, wherein the dispensing device 10 is used for executing a sample and/or reagent dispensing operation; a detecting device 60 for performing a detecting operation on the reaction liquid in the reaction cup 4011; scheduling means for performing scheduling of the cuvette 4011;

the sample analyzer 100 performs a sample detection operation on a sample to be detected within a sample detection period, and the sample detection period T at least includes a sampling action sub-period, an incubation action sub-period, a magnetic separation action sub-period, and a cuvette processing action sub-period;

the control device 70 performs, during the sample analyzer 100 performs the sample detection operation on the sample to be detected in the sample detection period T: in a sampling operation sub-period of the sample detection period T, the dispensing device 10 is controlled to perform a sample and reagent dispensing operation to the cuvette 4011 so that the sample and the reagent are mixed in the cuvette 4011 to form a reaction liquid; in the incubation action sub-period of the sample detection period T, the reaction device 40 is controlled to incubate the reaction liquid in the reaction cup 4011 placed in the reaction position; in the magnetic separation action sub-period of the sample detection period T, controlling the magnetic separation device 80 to perform magnetic separation cleaning on the reaction liquid which is incubated and placed in the reaction cup 4011 at the magnetic separation position; in the reaction cup processing action sub-period of the sample detection period T, the detection device 60 is controlled to detect the reaction liquid in the reaction cup 4011 which is subjected to magnetic separation cleaning, and the scheduling device is controlled to process the reaction cup 4011 which is subjected to detection;

The control device 70 is also configured to: inserting a dummy cup operation flow before the sample analyzer 100 performs a magnetic separation action sub-cycle of a sample detection cycle;

in the empty cup operation flow, the control device 70 controls at least the dispatching device to dispatch the reaction cup 4011 without the reaction liquid to the magnetic separation position of the magnetic separation device 80, and controls the liquid injection component 802 of the magnetic separation device 80 to drain the cleaning liquid in the liquid injection component 802 to the reaction cup 4011 at the magnetic separation position.

Referring to fig. 7A and 7B, the sample analyzer 100 can perform detection of a sample to be detected in one sample detection period, for example. And to increase the throughput of sample testing, the sample analyzer 100 may perform testing of multiple samples under test simultaneously at the same time. The sample detection period T at least comprises a sampling action sub-period, an incubation action sub-period, a magnetic separation action sub-period and a reaction cup processing action sub-period.

Taking a single sample detection cycle as an example, the dispensing device 10 of the sample analyzer 100 performs a sample and reagent dispensing operation on the reaction cup 4011 in a sampling operation sub-cycle of the sample detection cycle, so that the sample and the reagent are mixed in the reaction cup 4011 to form a reaction liquid, for example, the sample analyzer 100 dispatches a new reaction cup to a preset sample adding position, the dispensing device 10 dispatches a sample to be tested to the reaction cup placed in the sample adding position, after the sample is completely filled, the reaction cup bearing the sample liquid is dispatched to a preset reagent position, then the dispensing device 10 dispatches a corresponding reagent to the reaction cup placed in the reagent position, after the sample and reagent dispensing operation is completed, the reaction cup 4011 bearing the reaction liquid formed by mixing the sample and the reagent is dispatched to the reaction position of the reaction device 40 in an incubation operation sub-cycle dispatching device so as to incubate the reaction liquid in the reaction cup 4011 in the reaction position. Or after the sample and reagent dispensing operation is completed, the reaction cup bearing the sample and reagent is dispatched to the mixing position of the mixing device 50 to perform the mixing operation so as to fully mix the sample and the reagent to form the reaction liquid, and after the mixing operation is completed, the reaction cup 4011 bearing the reaction liquid formed by mixing the sample and the reagent is dispatched to the reaction position of the reaction device 40 by the incubation action subcycle dispatching device so as to incubate the reaction liquid in the reaction cup 4011 in the reaction position.

After the incubation operation performed by the reaction device 40 is completed, the magnetic separation sub-cycle is performed by the internal dispatching device to dispatch the reaction cup 4011 completed with the incubation to the magnetic separation position of the magnetic separation device 80 so as to perform the magnetic separation cleaning operation on the reaction liquid in the reaction cup 4011 at the magnetic separation position, and after the magnetic separation cleaning is completed, the reaction cup 4011 completed with the magnetic separation cleaning is dispatched to the detection position by the dispatching device to enable the detection device 60 to detect the reaction liquid in the reaction cup 4011 completed with the magnetic separation cleaning at the detection position and control the dispatching device to process the reaction cup 4011 completed with the detection, for example, the reaction cup 4011 completed with the detection is dispatched to the recovery device to be recovered by the reaction cup 4011.

Because the operations performed by the sample analyzer 100 are different in each operation sub-cycle, the devices and components for performing the corresponding operations are also different, and in order to fully utilize the devices and components of the sample analyzer, when the sample analyzer 100 simultaneously performs a plurality of sample detection cycles, the operation sub-cycles correspondingly performed by the sample analyzer at the same time are different or the operation phases performed in the same operation sub-cycle are different.

As shown in fig. 7B, in a state where the sample analyzer 100 simultaneously performs two different sample detection periods test1, test2, for example, when the sample analyzer performs an operation of dispatching a new cuvette to a preset loading site for the first sample detection period test1, the second sample detection period test2 has not yet started to be performed.

For another example, when the sample analyzer performs a sample filling operation on a cuvette at a loading site in the first sample detection period test1, the sample analyzer performs an operation of scheduling a new cuvette to a preset loading site in the second sample detection period test 2.

As another example, when the sample analyzer performs a reagent filling operation on a cuvette located at a reagent level in the first sample detection period test1, the sample analyzer performs a sample filling operation on a cuvette located at a sample level in the second sample detection period test 2.

Or, for another example, when the sample analyzer is performing a magnetic separation operation on the reaction liquid of the cuvette in the first sample detection period test1, the sample analyzer is performing an incubation operation on the reaction liquid of the cuvette in the second sample detection period test 2.

Meanwhile, in order to reduce the influence of temperature on the magnetic separation device 80 during the execution of the sample detection period, the empty cup operation flow is inserted before the sample analyzer 100 executes the magnetic separation action sub-period of the sample detection period, and during the execution of the empty cup operation flow, the control device 70 at least controls the dispatching device to dispatch the reaction cup 4011 without the reaction liquid to the magnetic separation position of the magnetic separation device 80, and controls the liquid injection component 802 to drain the cleaning liquid in the liquid injection component 802 to the reaction cup 4011 at the magnetic separation position, so that the accuracy of the amount of the cleaning liquid emitted by the liquid injection component 802 during the magnetic separation action sub-period of the sample detection period of the sample analyzer meets the preset requirement, and the temperature of the cleaning liquid is within the preset temperature range, so as to reduce the influence of the temperature on the magnetic separation cleaning operation, and further improve the accuracy of the sample analysis result.

As shown in fig. 7C, if the cleaning liquid in the liquid injection unit 802 of the magnetic separator 80 needs to be discharged before the sample detection period test1, the empty cup operation flow K is inserted before the magnetic separation operation sub-period of the sample detection period test 1.

In some embodiments, the control device 70 is further configured to: the empty cup operation flow is performed in a target action sub-period before the magnetic separation action sub-period of the sample detection period is performed by the sample analyzer 100, wherein the target action sub-period at least comprises at least one of a sampling action sub-period and the incubation action sub-period.

Illustratively, to ensure that the sample analyzer 100 discharges the cleaning fluid within the fluid injection assembly 802 of the magnetic separation device 80 prior to performing the magnetic separation action sub-cycle of the sample detection cycle T, the time node at which the sample analyzer 100 performs the empty cup operation procedure may perform the empty cup operation procedure one target action sub-cycle of the person prior to the magnetic separation action sub-cycle of the sample detection cycle, i.e., at least one of the sampling action sub-cycle and the incubation action sub-cycle.

In some embodiments, the cuvette handling flow path includes a cuvette handling flow path and a cuvette handling flow path, and the magnetic separation device 80 further includes a pipetting assembly 803, where the pipetting assembly 803 is configured to aspirate a solution in the cuvette 4011;

In the empty cup scheduling sub-process, the control device 70 controls the scheduling device to schedule the reaction cup 4011 without the reaction liquid to the magnetic separation position, controls the liquid injection component 802 to drain the cleaning liquid in the liquid injection component 802 to the reaction cup 4011 at the magnetic separation position, and controls the liquid suction component 803 to suck the cleaning liquid in the reaction cup 4011 after the liquid injection, as shown in fig. 7D.

In the sub-process of processing the reaction cup, the control device 70 controls the dispatching device to dispatch the reaction cup 4011 in the magnetic separation position to a preset temporary storage position, wherein the reaction cup 4011 without reaction liquid can be an empty reaction cup 4011 placed in the temporary storage position or an empty reaction cup 4011 supplied by a cup supplying mechanism.

In some embodiments, the control device 70 is further configured to: in a reaction cup processing sub-process of the empty cup operation process, when the use times of the reaction cup 4011 are smaller than or equal to the preset times, controlling the dispatching device to dispatch the reaction cup 4011 from the magnetic separation position to the temporary storage position; when the number of times of using the reaction cup 4011 is larger than a preset number of times, controlling the dispatching device to dispatch the reaction cup 4011 from the magnetic separation position to the reaction cup recovery mechanism;

Or, when the number of times of use of the cuvette 4011 placed in the temporary storage position is greater than a preset number of times or the time of use of the cuvette 4011 reaches a preset time period, the scheduling device is controlled to schedule the cuvette 4011 in the temporary storage position to the cuvette recycling mechanism.

Illustratively, in the cuvette handling sub-process of the cuvette handling sub-process, if the number of times of use of the cuvette 4011 is less than or equal to the preset number of times, the cuvette 4011 is considered to be uncontaminated, the control scheduling device schedules the cuvette 4011 from the magnetic separation position to the temporary storage position, and when the number of times of use of the cuvette 4011 is greater than the preset number of times, the cuvette 4011 is considered to be contaminated, and in order to avoid the adverse effect of the contaminated cuvette 4011 on the detection result of the sample analysis, the control scheduling device schedules the cuvette 4011 from the magnetic separation position to the cuvette recovery mechanism of the sample analyzer 100, thereby realizing the recovery of the cuvette 4011.

Similarly, when the number of times of use of the cuvette 4011 placed in the temporary storage position is greater than the preset number of times or the time of use of the cuvette 4011 reaches the preset time, the cuvette 4011 is considered to be polluted, and at this time, the dispatching device is controlled to dispatch the cuvette 4011 from the magnetic separation position to the cuvette recycling mechanism of the sample analyzer 100, so as to recycle the cuvette 4011.

In some embodiments, the control device 70 is further configured to: if the temporary storage position is provided with the reaction cup 4011, in an empty cup scheduling sub-process of the empty cup operation process, the scheduling device is controlled to schedule the reaction cup 4011 arranged in the temporary storage position to a magnetic separation position of the magnetic separation device 80, and the cleaning liquid in the liquid injection component is discharged to the reaction cup 4011 in the magnetic separation position.

In some embodiments, the control device 70 is further configured to: if the temporary storage position is not provided with a reaction cup 4011, the control device controls the scheduling device to schedule the reaction cup 4011 in the cup supply mechanism to a preset sample adding position in a time period corresponding to a sampling action sub-period of the sample detection period in the empty cup scheduling sub-process, controls the dispensing device to not execute sample dispensing operation, controls the scheduling device to schedule the reaction cup 4011 positioned at the sample adding position to the reaction position, and controls the dispensing device 10 to not execute reagent dispensing operation; and controlling the dispatching device to dispatch the cuvette 4011 in the reaction position to the magnetic separation position in a time period corresponding to the incubation action sub-period of the sample detection period in the empty cuvette dispatching sub-flow.

In the empty cup scheduling process, before the reaction cup 4011 in the temporary storage position is scheduled to the magnetic separation position, it is determined whether the reaction cup 4011 is placed in the temporary storage position, if the reaction cup 4011 is placed in the temporary storage position, in the empty cup scheduling sub-process of the empty cup operation process, the priority control scheduling device schedules the reaction cup 4011 placed in the temporary storage position to the magnetic separation position of the magnetic separation device 80, and controls the liquid injection component 802 to perform a liquid discharge operation on the reaction cup 4011 placed in the magnetic separation position, so as to discharge the cleaning liquid in the liquid injection component 802 into the reaction cup 4011 in the magnetic separation position.

If the reaction cup 4011 is not placed in the temporary storage position, the reaction cup 4011 is transferred from the cup supply mechanism, and in the transferring process of the reaction cup 4011, the dispatching device is controlled to dispatch the reaction cup 4011 in the cup supply mechanism to a preset sample adding position, and the dispensing device 10 is controlled not to execute sample dispensing operation, so that no sample is injected into the reaction cup 4011. After the cuvette 4011 is dispatched to the sample adding position, controlling the dispatching device to dispatch the cuvette 4011 positioned at the sample adding position to the reaction position of the reaction device 40, and controlling the dispensing device 10 not to execute the reagent dispensing operation so as to ensure that no reagent is injected into the cuvette 4011; and in the empty cup scheduling sub-flow, controlling a scheduling device to schedule the reaction cup 4011 in the reaction position to the magnetic separation position in a time period corresponding to the incubation action sub-period of the sample detection period.

As shown in fig. 7B, in some embodiments, the sample analyzer further includes a mixing device 50, where the mixing device 50 is provided with at least one mixing position, and is configured to perform a mixing operation on the reaction solution in the reaction cup 4011 placed in the mixing position; the sample detection period and the cup empty operation flow further comprise a mixing action sub-period, and the control device is further used for:

in a mixing action sub-period of the sample detection period, controlling the scheduling device to schedule the reaction cup 4011 at the sample adding position to the mixing position, and controlling the mixing device to mix the reaction liquid in the reaction cup 4011 at the mixing position;

when the temporary storage position is a mixing position of the mixing device 50, if the mixing position is provided with a reaction cup 4011, in the empty cup scheduling sub-flow, a period corresponding to a mixing action sub-period of the sample detection period is controlled to not perform a mixing operation by the mixing device 50, and in the empty cup scheduling sub-flow, a period corresponding to an incubation action sub-period of the sample detection period is controlled to schedule the reaction cup 4011 positioned at the mixing position to a reaction position of the reaction device 40, and the reaction device 40 is controlled to not perform an incubation operation, and the reaction cup 4011 is controlled to schedule from the reaction position to a magnetic separation position of the magnetic separation device 80 by the scheduling device, and the cleaning liquid in the liquid injection component 802 is controlled to be discharged into the reaction cup 4011 of the magnetic separation position by the liquid injection component 802.

Based on the fact that the time node corresponding to the empty cup scheduling sub-flow scheduling device when the scheduling task is executed is matched with the time node of the scheduling device when the scheduling task is executed in the sample detection period, the scheduling device does not need to conduct time sequence adjustment after the empty cup scheduling sub-flow is finished, and the scheduling task in the next sample detection period can be directly executed.

In some embodiments, the magnetic separation device further comprises a substrate injection assembly for injecting a substrate into the reaction cup after completing magnetic separation washing in the magnetic separation site during a magnetic separation action sub-cycle of the sample detection cycle; the control device is also used for:

and controlling the substrate injection assembly not to execute the operation of injecting the substrate into the reaction cup in the empty cup dispatching sub-process of the empty cup operation process.

In some embodiments, the magnetic separation assembly comprises two magnetic separation assemblies, and the two magnetic separation assemblies are configured such that one receives the reaction cup loaded with the reaction liquid and magnetically separates the reaction liquid within the reaction cup during an odd number of sample detection periods, and the other receives the reaction cup loaded with the reaction liquid and magnetically separates the reaction liquid within the reaction cup during an even number of sample detection periods; the control device is also used for:

Determining that a sample detection period corresponding to the magnetic separation component meeting the preset condition when the magnetic separation component executes the magnetic separation operation is an odd number period or an even number period;

when the sample detection period corresponding to the magnetic separation assembly meeting the preset conditions is an odd number period when the magnetic separation assembly executes the magnetic separation operation, inserting an empty cup operation flow before the magnetic separation action sub-period of the current odd number period;

when the sample detection period corresponding to the magnetic separation assembly meeting the preset conditions is an even number period when the magnetic separation assembly executes the magnetic separation operation, inserting an empty cup operation flow before the magnetic separation action sub-period of the current even number period;

the preset condition comprises at least one of that the current ambient temperature is smaller than a preset temperature and that the time interval between two liquid injection operations of the liquid injection assembly is larger than a preset time interval.

Illustratively, the two magnetic separation assemblies 801 operate independently of each other, and the two magnetic separation assemblies 801 are configured such that one receives the cuvette 4011 carrying the reaction liquid and magnetically separates the reaction liquid in the cuvette 4011 during an odd number of sample detection periods T, and the other receives the cuvette 4011 carrying the reaction liquid and magnetically separates the reaction liquid in the cuvette 4011 during an even number of sample detection periods T.

It can be understood that the liquid injection assembly 802 of the corresponding magnetic separation device 80 may be one liquid injection assembly 802 shared by two magnetic separation assemblies 801, or the magnetic separation device 80 may be provided with two independent liquid injection assemblies 802, and each magnetic separation assembly 801 is provided with one liquid injection assembly 802.

Based on two magnetic separation components 801, one of the magnetic separation components 801 works in an odd sample detection period and the other works in an even sample detection period, before the empty cup operation flow is inserted before the magnetic separation action sub-period of the corresponding sample detection period, the current sample detection period corresponding to the magnetic separation component 801 meeting the preset condition needs to be determined to be an odd period or an even period, wherein the preset condition comprises at least one of that the current ambient temperature is smaller than a preset temperature, and that the time interval between two liquid injection operations of the liquid injection component is larger than a preset time interval.

In some embodiments, the empty cup operation flow comprises at least one empty detection cycle, the empty detection cycle comprising at least a sampling action sub-cycle, an incubation action sub-cycle, a magnetic separation action sub-cycle, and a reaction cup processing action sub-cycle;

the control device is also used for: in the magnetic separation action sub-period of the empty detection period, controlling the dispatching device to dispatch the reaction cup 4011 which does not bear the reaction liquid to the magnetic separation position, and controlling the liquid injection component 802 to drain the cleaning liquid in the liquid injection component 802 so as to drain the cleaning liquid in the liquid injection component 802 to the reaction cup 4011 at the magnetic separation position; controlling the dispensing device 10 not to perform the sample dispensing operation and the reagent dispensing operation in the sampling operation sub-period of the empty detection period; and controlling the reaction device 40 not to perform incubation operation in the incubation action sub-period of the empty detection period; and a cuvette handling operation sub-cycle control and dispatch device for dispatching the cuvette 4011 in the magnetic separation position to a preset temporary storage position or dispatching the cuvette 4011 from the magnetic separation position to a cuvette recycling mechanism of the sample analyzer 100 in the empty detection cycle.

As shown in fig. 8A, the empty cup operation flow includes an empty detection period Tk including a sampling action sub-period, an incubation action sub-period, a magnetic separation action sub-period, and a cuvette processing action sub-period.

In some embodiments, the magnetic separation device 80 further comprises a pipetting assembly 803, the pipetting assembly 803 being for pipetting a solution in the cuvette 4011; after the liquid injection component 802 injects the cleaning liquid into the reaction cup 4011 without the reaction liquid in the magnetic separation position, the liquid suction component 803 is controlled to suck the cleaning liquid in the injected reaction cup 4011;

the control device 70 is also configured to: in the sub-period of the reaction cup processing action of the empty detection period, the control and dispatch device dispatches the reaction cup 4011 in the magnetic separation position to a preset temporary storage position.

In some embodiments, during the sub-cycle of the cuvette handling operation during the empty detection cycle, when the number of uses of the cuvette 4011 is less than or equal to a preset number of times, the control scheduling device schedules the cuvette 4011 from the magnetic separation position to the temporary storage position; when the using times of the reaction cup 4011 are larger than the preset times, controlling the dispatching device to dispatch the reaction cup 4011 from the magnetic separation position to the reaction cup recycling mechanism;

or, when the number of times of use of the cuvette 4011 placed in the temporary storage position is greater than the preset number of times or the time of use of the cuvette 4011 reaches the preset time, the control scheduling device schedules the cuvette 4011 in the temporary storage position to the cuvette recycling mechanism.

In some embodiments, if the cuvette 4011 is placed at the temporary storage position, the control and dispatch device dispatches the cuvette 4011 placed at the temporary storage position to the magnetic separation position and discharges the cleaning liquid in the liquid injection component 802 to the cuvette 4011 at the magnetic separation position in the magnetic separation action sub-period of the empty detection period.

In some embodiments, if the temporary storage position is not provided with the reaction cup 4011, the control device 70 controls the scheduling device to schedule the reaction cup 4011 in the cup supplying mechanism to a preset sample adding position in a sampling action sub-period of the empty detection period, controls the dispensing device to not perform a sample dispensing operation, and controls the scheduling device to schedule the reaction cup 4011 located at the sample adding position to the reaction position, and controls the dispensing device to not perform a reagent dispensing operation; and in the incubation action sub-period of the empty detection period, the control and dispatch device dispatches the cuvette 4011 in the reaction position to the magnetic separation position.

In some embodiments, the sample analyzer further comprises a mixing device 50, wherein the mixing device 50 is provided with at least one mixing position and is used for performing a mixing operation on the reaction solution in the reaction cup 4011 placed in the mixing position; the sample detection period and the null detection period further comprise a mixing action sub-period, and the control device 70 is further configured to:

In a mixing action sub-period of the sample detection period, controlling a scheduling device to schedule the reaction cup 4011 at the sample adding position to a mixing position, and controlling a mixing device 50 to mix the reaction liquid in the reaction cup 4011 at the mixing position;

when the temporary storage position is a mixing position of the mixing device 50, if the reaction cup 4011 is placed at the mixing position, the mixing device 50 is controlled not to perform mixing operation in a mixing action sub-period of an empty detection period, the reaction cup 4011 positioned at the mixing position is controlled to be scheduled to the reaction position by the control scheduling device in an incubation action sub-period of the empty detection period, the reaction device 40 is controlled not to perform incubation operation, and the reaction cup 4011 is controlled to be scheduled to the magnetic separation position from the reaction position by the control scheduling device in a magnetic separation action sub-period of the empty detection period, and the cleaning liquid in the liquid injection component is controlled to be discharged into the reaction cup 4011 of the magnetic separation position by the control liquid injection component.

As shown in fig. 8B, the empty detection period Tk includes a sampling operation sub-period, a mixing operation sub-period, an incubation operation sub-period, a magnetic separation operation sub-period, and a cuvette processing operation sub-period.

In some embodiments, the magnetic separation device further comprises a substrate injection assembly for injecting a substrate into the cuvette 4011 after completion of magnetic separation cleaning in the magnetic separation site during a magnetic separation action sub-cycle of the sample detection cycle; the control device 70 is also configured to:

In the magnetic separation operation sub-period of the empty detection period, the substrate injection unit is controlled not to perform the operation of injecting the substrate into the cuvette 4011.

A method for controlling injection according to the embodiment of the present application will be described below with reference to the working principle of the sample analyzer 100.

The liquid injection control method is applied to a sample analyzer, and comprises the following steps:

before a liquid injection component of the sample analyzer injects cleaning liquid into a reaction cup to be subjected to magnetic separation cleaning in a magnetic separation position of a magnetic separation device of the sample analyzer, controlling the liquid injection component to at least drain the cleaning liquid in the liquid injection component.

In some embodiments, the controlling the priming member to drain at least cleaning liquid located within the priming member comprises: acquiring a current environment temperature, and if the current environment temperature is smaller than a preset temperature, controlling the liquid injection assembly to drain at least the cleaning liquid in the liquid injection assembly before the liquid injection assembly injects the cleaning liquid into the reaction cup to be subjected to magnetic separation cleaning in the magnetic separation position;

or when the time interval of the two liquid injection operations of the liquid injection assembly is larger than the preset time interval, controlling the liquid injection assembly to drain the cleaning liquid in the liquid injection assembly between the two liquid injection operations of the liquid injection assembly.

In some embodiments, the sample analyzer further comprises:

a dispensing device for performing a sample and/or reagent dispensing operation;

the detection device is used for executing detection operation on the reaction liquid in the reaction cup;

the dispatching device is used for executing the dispatching of the reaction cups;

the sample analyzer executes sample detection operation on a sample to be detected in a sample detection period, wherein the sample detection period at least comprises a sampling action sub-period, an incubation action sub-period, a magnetic separation action sub-period and a reaction cup processing action sub-period;

the sample detection operation is executed on the sample to be detected in the sample detection period, and specifically includes:

in a sampling action sub-period of the sample detection period, controlling the dispensing device to perform sample and reagent dispensing operation on the reaction cup so as to mix the sample and the reagent in the reaction cup to form a reaction liquid; in an incubation action sub-period of the sample detection period, controlling the reaction device to incubate the reaction liquid in the reaction cup at the reaction position; in a magnetic separation action sub-period of the sample detection period, controlling the magnetic separation device to perform magnetic separation cleaning on the reaction liquid which is incubated and placed in the reaction cup at the magnetic separation position; in a reaction cup processing action sub-period of the sample detection period, controlling the detection device to detect reaction liquid in the reaction cup subjected to magnetic separation cleaning, and controlling the dispatching device to process the reaction cup subjected to detection;

The method further comprises the steps of: inserting an empty cup operation flow before the sample analyzer executes a magnetic separation action sub-period of the sample detection period;

the empty cup operation flow comprises at least controlling the dispatching device to dispatch the reaction cup without the reaction liquid to the magnetic separation position, and controlling the liquid injection assembly to drain the cleaning liquid in the liquid injection assembly so as to drain the cleaning liquid in the liquid injection assembly to the reaction cup at the magnetic separation position.

In some embodiments, inserting the empty cup operational flow before the sample analyzer performs the magnetic separation action sub-cycle of the sample detection cycle comprises:

the cup-empty operation flow is performed in a target action sub-period preceding a magnetic separation action sub-period in which the sample analyzer performs the sample detection period, wherein the target action sub-period includes at least one of the sampling action sub-period and the incubation action sub-period.

In some embodiments, the cuvette handling flow path includes a cuvette handling flow path and a cuvette handling flow path, and the magnetic separation device further includes a pipetting assembly for pipetting the solution in the cuvette; the method further comprises the steps of:

In the empty cup dispatching sub-process, controlling the dispatching device to dispatch the reaction cup without the reaction liquid to the magnetic separation position, controlling the liquid injection assembly to drain the cleaning liquid in the liquid injection assembly to the reaction cup at the magnetic separation position, and controlling the liquid suction assembly to suck the cleaning liquid in the reaction cup after the liquid injection;

and in the reaction cup processing sub-process, controlling the dispatching device to dispatch the reaction cups in the magnetic separation position to a preset temporary storage position.

In some embodiments, the method further comprises: when the using times of the reaction cup are smaller than or equal to the preset times in the reaction cup processing sub-process, controlling the dispatching device to dispatch the reaction cup from the magnetic separation position to the temporary storage position; when the using times of the reaction cup is larger than the preset times, controlling the dispatching device to dispatch the reaction cup from the magnetic separation position to the reaction cup recycling mechanism;

or when the using times of the reaction cups placed in the temporary storage position are larger than the preset times or the using time of the reaction cups reaches the preset time, controlling the dispatching device to dispatch the reaction cups in the temporary storage position to the reaction cup recycling mechanism.

In some embodiments, the method further comprises: if the reaction cup is placed at the temporary storage position, controlling the dispatching device to dispatch the reaction cup placed at the temporary storage position to the magnetic separation position in an empty cup dispatching sub-process of the empty cup operation process, and discharging the cleaning liquid in the liquid injection assembly to the reaction cup at the magnetic separation position.

In some embodiments, the method further comprises: if the temporary storage position is not provided with a reaction cup, controlling the dispatching device to dispatch the reaction cup in the cup supplying mechanism to a preset sample adding position in a time period corresponding to a sampling action sub-period of the sample detection period in the empty cup dispatching sub-process, controlling the dispensing device to not execute sample dispensing operation, controlling the dispatching device to dispatch the reaction cup positioned in the sample adding position to the reaction position, and controlling the dispensing device not to execute reagent dispensing operation; and controlling the dispatching device to dispatch the reaction cup in the reaction position to the magnetic separation position.

In some embodiments, the sample analyzer further comprises a mixing device, wherein the mixing device is provided with at least one mixing position and is used for performing mixing operation on the reaction liquid in the reaction cup placed in the mixing position; the sample detection period further includes a mixing action sub-period, the method further including:

In a mixing action sub-period of the sample detection period, controlling the scheduling device to schedule the reaction cup at the sample adding position to the mixing position, and controlling the mixing device to mix the reaction liquid in the reaction cup at the mixing position;

when the temporary storage position is a mixing position of the mixing device, if a reaction cup is placed at the mixing position, in the empty cup scheduling sub-process, a mixing operation is not executed by the mixing device in a time period corresponding to a mixing action sub-period of the sample detection period, in the empty cup scheduling sub-process, a reaction cup positioned at the mixing position is scheduled to the reaction position by the scheduling device in a time period corresponding to an incubation action sub-period of the sample detection period, the incubation operation is not executed by the reaction device, the reaction cup is scheduled to the magnetic separation position by the scheduling device from the reaction position, and the cleaning liquid in the liquid injection assembly is discharged to the reaction cup of the magnetic separation position by the liquid injection assembly.

In some embodiments, the magnetic separation device further comprises a substrate injection assembly for injecting a substrate into the reaction cup after completion of magnetic separation washing in the magnetic separation site during a magnetic separation action sub-cycle of the sample detection cycle;

The method further comprises the steps of: and controlling the substrate injection assembly not to execute the operation of injecting the substrate into the reaction cup in the empty cup dispatching sub-process of the empty cup operation process.

In some embodiments, the magnetic separation assembly comprises two magnetic separation assemblies, and the two magnetic separation assemblies are configured such that one receives the reaction cup loaded with the reaction liquid and magnetically separates the reaction liquid within the reaction cup during an odd number of sample detection periods, and the other receives the reaction cup loaded with the reaction liquid and magnetically separates the reaction liquid within the reaction cup during an even number of sample detection periods;

the method further comprises the steps of: determining that a sample detection period corresponding to the magnetic separation component meeting the preset condition when the magnetic separation component executes the magnetic separation operation is an odd number period or an even number period;

In some embodiments, the empty cup operation flow comprises at least one empty detection cycle, wherein the empty detection cycle comprises at least a sampling action sub-cycle, an incubation action sub-cycle, a magnetic separation action sub-cycle and a reaction cup processing action sub-cycle;

the method further comprises the steps of: in the magnetic separation action sub-period of the empty detection period, controlling the dispatching device to dispatch the reaction cup which does not bear the reaction liquid to the magnetic separation position, and controlling the liquid injection assembly to drain the cleaning liquid in the liquid injection assembly so as to drain the cleaning liquid in the liquid injection assembly to the reaction cup at the magnetic separation position;

controlling the dispensing device to not execute sample dispensing operation and reagent dispensing operation in a sampling action sub-period of the empty detection period; and controlling the reaction device to not perform incubation operation in an incubation action sub-period of the empty detection period; and controlling the dispatching device to dispatch the reaction cup in the magnetic separation position to a preset temporary storage position or to dispatch the reaction cup from the magnetic separation position to a reaction cup recycling mechanism of the sample analyzer in a reaction cup processing action subcycle of the empty detection period.

the method further comprises the steps of: in the sub-period of the reaction cup processing action of the empty detection period, the control and dispatch device dispatches the reaction cup 4011 in the magnetic separation position to a preset temporary storage position.

In some embodiments, the method further comprises: in the reaction cup processing action sub-period of the empty detection period, when the use times of the reaction cup 4011 are smaller than or equal to the preset times, controlling a dispatching device to dispatch the reaction cup 4011 from the magnetic separation position to the temporary storage position; when the using times of the reaction cup 4011 are larger than the preset times, controlling the dispatching device to dispatch the reaction cup 4011 from the magnetic separation position to the reaction cup recycling mechanism;

In some embodiments, the method further comprises: if the reaction cup 4011 is placed at the temporary storage position, the control and dispatch device dispatches the reaction cup 4011 placed at the temporary storage position to the magnetic separation position in the magnetic separation action sub-period of the empty detection period, and discharges the cleaning liquid in the liquid injection assembly 802 to the reaction cup 4011 at the magnetic separation position.

In some embodiments, the method further comprises: if the temporary storage position is not provided with the reaction cup 4011, the control device 70 controls the scheduling device to schedule the reaction cup 4011 in the cup supplying mechanism to a preset sample adding position in a sampling action sub-period of the empty detection period, controls the dispensing device to not execute sample dispensing operation, and controls the scheduling device to schedule the reaction cup 4011 positioned in the sample adding position to the reaction position, and controls the dispensing device not to execute reagent dispensing operation; and in the incubation action sub-period of the empty detection period, the control and dispatch device dispatches the cuvette 4011 in the reaction position to the magnetic separation position.

In some embodiments, the sample analyzer further comprises a mixing device 50, wherein the mixing device 50 is provided with at least one mixing position and is used for performing a mixing operation on the reaction solution in the reaction cup 4011 placed in the mixing position; the sample detection period and the null detection period further comprise a mixing action sub-period, the method further comprising:

when the temporary storage position is a mixing position of the mixing device 50, if the reaction cup 4011 is placed at the mixing position, the mixing device 50 is controlled not to perform the mixing operation in a mixing operation sub-period of the empty detection period, the reaction cup 4011 positioned at the mixing position is controlled to be scheduled to the reaction position by the control scheduling device in an incubation operation sub-period of the empty detection period, the reaction device 40 is controlled not to perform the incubation operation, and the reaction cup 4011 is controlled to be scheduled to the magnetic separation position from the reaction position by the control scheduling device in a magnetic separation operation sub-period of the empty detection period, and the cleaning liquid in the liquid injection component 802 is controlled to be discharged into the reaction cup 4011 of the magnetic separation position by the control liquid injection component 802.

In some embodiments, the magnetic separation device further comprises a substrate injection assembly for injecting a substrate into the cuvette 4011 after completion of magnetic separation cleaning in the magnetic separation site during a magnetic separation action sub-cycle of the sample detection cycle; the method further comprises the steps of:

It should be noted that, for convenience and brevity of description, specific working procedures of the above-described liquid injection control method may refer to corresponding working procedures of the above-described sample analyzer, and will not be described herein.

It is to be noted that the period is a fixed duration, but how to divide the start and end of each period may be divided according to the actual situation, for example, if a period is 7 seconds, the 1 st and 7 th seconds may be divided into one period, and the 3 rd and 9 th seconds may be divided into one period, which makes the operations performed in the corresponding periods slightly different, and some examples mentioned above illustrate the operations performed by some devices and components in each period, but only one division of the period, and those skilled in the art will understand how to divide the start of the period, and thus the changes in the operations performed by the devices and components in each period, as long as the duration of the period is unchanged, which is within the contemplation of the present invention.

It is to be understood that the terminology used in the description of the present application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used in this specification and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.

It should also be understood that the term "and/or" as used in this specification and the appended claims refers to any and all possible combinations of one or more of the associated listed items, and includes such combinations. It should be noted that, in this document, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or system that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or system. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article, or system that comprises the element.

The foregoing embodiment numbers of the present application are merely for describing, and do not represent advantages or disadvantages of the embodiments. While the invention has been described with reference to certain preferred embodiments, it will be understood by those skilled in the art that various changes and substitutions of equivalents may be made and equivalents will be apparent to those skilled in the art without departing from the scope of the invention. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.

Claims

1. A sample analyzer, comprising:

control means for:

2. The sample analyzer of claim 1, wherein the control device is further configured to: acquiring a current environment temperature, and if the current environment temperature is smaller than a preset temperature, controlling the liquid injection assembly to drain at least the cleaning liquid in the liquid injection assembly before the liquid injection assembly injects the cleaning liquid into the reaction cup to be subjected to magnetic separation cleaning in the magnetic separation position;

3. The sample analyzer of claim 1, further comprising:

The control device executes in the process that the sample analyzer executes sample detection operation on a sample to be detected in a sample detection period: in a sampling action sub-period of the sample detection period, controlling the dispensing device to perform sample and reagent dispensing operation on the reaction cup so as to mix the sample and the reagent in the reaction cup to form a reaction liquid; in an incubation action sub-period of the sample detection period, controlling the reaction device to incubate the reaction liquid in the reaction cup at the reaction position; in a magnetic separation action sub-period of the sample detection period, controlling the magnetic separation device to perform magnetic separation cleaning on the reaction liquid which is incubated and placed in the reaction cup at the magnetic separation position; in a reaction cup processing action sub-period of the sample detection period, controlling the detection device to detect reaction liquid in the reaction cup subjected to magnetic separation cleaning, and controlling the dispatching device to process the reaction cup subjected to detection;

the control device is also used for: inserting an empty cup operation flow before the sample analyzer executes a magnetic separation action sub-period of the sample detection period;

in the empty cup operation flow, the control device at least controls the dispatching device to dispatch the reaction cup without the reaction liquid to the magnetic separation position, and controls the liquid injection assembly to drain the cleaning liquid in the liquid injection assembly, so as to drain the cleaning liquid in the liquid injection assembly to the reaction cup at the magnetic separation position.

4. A sample analyser as claimed in claim 3 wherein the control means is further for: the cup-empty operation flow is performed in a target action sub-period preceding a magnetic separation action sub-period in which the sample analyzer performs the sample detection period, wherein the target action sub-period includes at least one of the sampling action sub-period and the incubation action sub-period.

5. The sample analyzer of claim 3, wherein the cuvette handling flow path includes a cuvette handling sub-flow path and a cuvette handling sub-flow path, the magnetic separation device further including a pipetting assembly for pipetting solution in the cuvette;

in the empty cup dispatching sub-process, the control device controls the dispatching device to dispatch the reaction cup without the reaction liquid to the magnetic separation position, controls the liquid injection assembly to drain the cleaning liquid in the liquid injection assembly to the reaction cup at the magnetic separation position, and controls the liquid suction assembly to suck the cleaning liquid in the reaction cup after the liquid injection;

6. The sample analyzer of claim 5, wherein the control device is further configured to:

in the reaction cup processing sub-flow, when the using times of the reaction cup is less than or equal to the preset times, controlling the dispatching device to dispatch the reaction cup from the magnetic separation position to the temporary storage position; when the using times of the reaction cup is larger than the preset times, controlling the dispatching device to dispatch the reaction cup from the magnetic separation position to the reaction cup recycling mechanism;

7. The sample analyzer of claim 5, wherein the control device is further configured to:

if the reaction cup is placed at the temporary storage position, controlling the dispatching device to dispatch the reaction cup placed at the temporary storage position to the magnetic separation position in an empty cup dispatching sub-process of the empty cup operation process, and discharging the cleaning liquid in the liquid injection assembly to the reaction cup at the magnetic separation position.

8. The sample analyzer according to claim 5, wherein if the temporary storage position is not provided with a reaction cup, the control device controls the scheduling device to schedule a reaction cup in the cup supply mechanism to a preset sample adding position, controls the dispensing device to not perform a sample dispensing operation, and controls the scheduling device to schedule a reaction cup in the sample adding position to the reaction position, and controls the dispensing device to not perform a reagent dispensing operation in a time period corresponding to a sampling action sub-period of the sample detection period in the empty cup scheduling sub-flow; and controlling the dispatching device to dispatch the reaction cup in the reaction position to the magnetic separation position.

9. The sample analyzer of claim 5, further comprising a mixing device provided with at least one mixing site and configured to perform a mixing operation on a reaction solution placed in a reaction cup of the mixing site; the sample detection period further comprises a mixing action sub-period, and the control device is further used for:

10. The sample analyzer of any one of claims 3-9, wherein the magnetic separation device further comprises a substrate injection assembly for injecting a substrate into the cuvette after completion of magnetic separation washing in the magnetic separation site during a magnetic separation action sub-cycle of the sample detection cycle; the control device is also used for:

11. The sample analyzer of any of claims 3-9, wherein the magnetic separation assembly comprises two magnetic separation assemblies, and wherein the two magnetic separation assemblies are configured such that one receives and magnetically separates reaction cuvettes loaded with reaction liquid during odd sample detection periods, and the other receives and magnetically separates reaction liquid within reaction cuvettes during even sample detection periods; the control device is also used for:

12. A sample analyzer according to claim 3, wherein the empty cup operation flow comprises at least one empty detection cycle comprising at least a sampling action sub-cycle, an incubation action sub-cycle, a magnetic separation action sub-cycle, and a cuvette handling action sub-cycle;

the control device is also used for: in the magnetic separation action sub-period of the empty detection period, controlling the dispatching device to dispatch the reaction cup which does not bear the reaction liquid to the magnetic separation position, and controlling the liquid injection assembly to drain the cleaning liquid in the liquid injection assembly so as to drain the cleaning liquid in the liquid injection assembly to the reaction cup at the magnetic separation position; controlling the dispensing device to not execute sample dispensing operation and reagent dispensing operation in a sampling action sub-period of the empty detection period; and controlling the reaction device to not perform incubation operation in an incubation action sub-period of the empty detection period; and controlling the dispatching device to dispatch the reaction cup in the magnetic separation position to a preset temporary storage position or to dispatch the reaction cup from the magnetic separation position to a reaction cup recycling mechanism of the sample analyzer in a reaction cup processing action subcycle of the empty detection period.

13. A method of controlling priming for a sample analyzer, the method comprising: