CN117752481B - Completely degradable magnesium alloy cardiovascular stent - Google Patents
Completely degradable magnesium alloy cardiovascular stent Download PDFInfo
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- CN117752481B CN117752481B CN202311799480.8A CN202311799480A CN117752481B CN 117752481 B CN117752481 B CN 117752481B CN 202311799480 A CN202311799480 A CN 202311799480A CN 117752481 B CN117752481 B CN 117752481B
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- 229910000861 Mg alloy Inorganic materials 0.000 title claims abstract description 22
- 230000002526 effect on cardiovascular system Effects 0.000 title claims abstract description 10
- 230000002792 vascular Effects 0.000 claims abstract description 62
- 210000004204 blood vessel Anatomy 0.000 claims abstract description 53
- 230000015556 catabolic process Effects 0.000 claims abstract description 16
- 238000006731 degradation reaction Methods 0.000 claims abstract description 16
- 238000003825 pressing Methods 0.000 claims description 35
- 239000003814 drug Substances 0.000 claims description 29
- 239000011248 coating agent Substances 0.000 claims description 11
- 238000000576 coating method Methods 0.000 claims description 11
- 229940079593 drug Drugs 0.000 claims description 8
- 230000000712 assembly Effects 0.000 claims description 7
- 238000000429 assembly Methods 0.000 claims description 7
- 229920000642 polymer Polymers 0.000 claims description 6
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims description 6
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims description 6
- 229960002930 sirolimus Drugs 0.000 claims description 6
- 239000000956 alloy Substances 0.000 claims description 4
- 239000002131 composite material Substances 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 abstract description 4
- 230000008602 contraction Effects 0.000 abstract description 4
- 230000004855 vascular circulation Effects 0.000 abstract description 4
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 7
- 210000003205 muscle Anatomy 0.000 description 6
- 239000000969 carrier Substances 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 208000007536 Thrombosis Diseases 0.000 description 4
- 238000002513 implantation Methods 0.000 description 4
- 238000000554 physical therapy Methods 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 206010020718 hyperplasia Diseases 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 208000026740 Congenital cardiovascular disease Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 238000003698 laser cutting Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 230000007281 self degradation Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
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Abstract
The invention relates to the technical field of vascular stents, and provides a fully degradable magnesium alloy cardiovascular stent, which comprises a vascular stent body and a blood vessel for placing the vascular stent body, wherein the vascular stent body comprises an upper branch pipe and a lower branch pipe which are arranged in the blood vessel; the first support components are designed into a plurality of first support components, and the first support components are distributed between the circumferential outer wall of the upper branch pipe and the circumferential outer wall of the lower branch pipe in an annular mode at equal intervals. The invention enables the whole vascular stent body to self-expand in the blood vessel, and can not generate deformation problem after expansion, thereby avoiding the condition that the strength of the vascular stent is insufficient and the vascular stent collapses when the angiogenesis is refined, preventing the whole vascular stent body from generating radial contraction phenomenon, avoiding affecting the subsequent vascular circulation performance, further inhibiting the problem of vascular refinement, preventing the stent main body from loosening and falling off after degradation, and ensuring the fixing performance of the whole vascular stent body.
Description
Technical Field
The invention relates to the technical field of vascular stents, in particular to a fully degradable magnesium alloy cardiovascular stent.
Background
The magnesium alloy bracket can support the diseased blood vessel at the initial stage of implantation, and prevent the diseased blood vessel from negative reconstruction. Along with the improvement of the surrounding environment of the diseased blood vessel and the completion of the remodeling of the blood vessel structure, the magnesium alloy stent in the blood vessel wall can be slowly corroded until the magnesium alloy stent is completely degraded, so that the occurrence of intimal hyperplasia and restenosis caused by the stimulation of the stent to the blood vessel wall in the later stage of implantation can be avoided. The degradation performance of the magnesium alloy bracket has good treatment effect on common cardiovascular patients, and has important treatment significance on infants, teenagers and the like suffering from congenital cardiovascular diseases. The vascular stent is made of AZ31 magnesium alloy as a degradable stent material, and the vascular stent is self-designed and processed by adopting a laser cutting method.
Through retrieving, patent publication number CN115300195A has a vascular stent, includes a plurality of wave forms circle of arranging along the axial, all wave form circle's crest and trough are the same in the position of circumference, be provided with a plurality of straight muscle in the circumference of wave form circle, the length direction of straight muscle is on a parallel with the axial and in circumference even interval arrangement, and is single straight muscle is connected with wave form circle's crest or trough, and is single straight muscle is connected all wave form circle. In the above scheme, through straight muscle connection wave form circle, the wave form circle is when carrying out radial expansion like this, and straight muscle can not take place deformation, and the length of whole vessel support in the axial can not too much change, after the vessel support arrives the affected part, can directly expand and need not consider the axial dimension change after the vessel support expands, and the axial dimension of vessel support can only produce the reduction of the length of crest to trough at most, and the reduction of this kind of degree is compared with whole vessel support its dimensional change very little.
The prior art, in combination with the above patent, has been found to suffer from the following disadvantages: the support degree of the degradable magnesium alloy vascular stent is supported only by virtue of the expansion capacity of the stent, and when angiogenesis refines, the vascular stent is not strong enough to collapse, so that the problem of radial contraction is generated due to the change of blood vessels, the refinement problem of the blood vessels cannot be solved, and the circulation performance of the subsequent blood vessels is affected, so that the design of the completely degradable magnesium alloy vascular stent is needed to solve the problems.
Disclosure of Invention
The invention provides a fully degradable magnesium alloy cardiovascular stent, which aims to solve the problem that the strength of the vascular stent is not enough to collapse when angiogenesis is refined, so that the vascular stent is suitable for the radial contraction problem caused by the change of blood vessels, the refinement problem of the blood vessels is not solved, and the subsequent vascular circulation performance is influenced.
The invention is realized in such a way that a completely degradable magnesium alloy cardiovascular stent comprises a vascular stent body and a blood vessel for placing the vascular stent body, wherein the vascular stent body comprises an upper branch pipe and a lower branch pipe which are arranged in the blood vessel;
the first bracket components are designed into a plurality of first bracket components, and the first bracket components are distributed between the circumferential outer wall of the upper branch pipe and the circumferential outer wall of the lower branch pipe in an annular mode at equal intervals;
The number of the telescopic components is twice that of the first bracket components, and the telescopic components are distributed at the bottom of the circumferential outer wall of the upper branch pipe in an annular mode at equal intervals and at the top of the circumferential outer wall of the lower branch pipe in an annular mode at equal intervals;
The second bracket component is arranged between one ends of the telescopic components on the same vertical line, and the positions of the second bracket component and the first bracket component are staggered;
And the anti-falling assembly is arranged at the middle position of the second bracket assembly.
Through the technical scheme, the whole vascular stent body can be self-developed in the blood vessel, so that the deformation problem can not occur after the whole vascular stent body is expanded, the condition that the strength of the vascular stent is insufficient and the vascular stent collapses when the angiogenesis is refined is avoided, the radial contraction phenomenon of the whole vascular stent body is prevented, the influence on the follow-up vascular circulation performance is avoided, and the problem of vascular refinement is further restrained.
Furthermore, a guide pipe is inserted in the middle position of the upper branch pipe and the middle position of the lower branch pipe, and an outer pipe sleeve is sleeved outside the guide pipe.
Through the technical scheme, the whole vascular stent is automatically unfolded in a manner of separating from the outer sleeve, and the operation of unfolding the whole vascular stent body in the prior art by utilizing the expansion manner of the balloon is not needed.
Further, a connecting rod which is distributed in an annular shape at equal distance is fixed between the bottom of the upper branch pipe and the top of the lower branch pipe, notches which are distributed in an annular shape at equal distance are formed in the circumferential inner wall of the upper branch pipe and the circumferential inner wall of the lower branch pipe, and the positions of the notches are staggered with the positions of the connecting rod.
Through above-mentioned technical scheme, consolidate last branch pipe and lower branch pipe, guarantee the steadiness performance of whole vessel support body.
Further, first bracket component is including the equidistance is offered at the movable groove of last branch pipe circumference outer wall and lower branch pipe circumference outer wall, and the inner wall of movable groove all activity is provided with the movable seat, the cross section of movable seat and the cross section of movable groove all are the T type, be fixed with first spring between the top of movable seat and the top of movable groove, the one end of two adjacent movable seats rotates respectively and is connected with first expansion rod and second expansion rod, and be located and be provided with same first bracket pole between the one end of two first expansion rods on the same vertical line, be provided with same second bracket pole between the one end of two second expansion rods on the same vertical line, the mounting groove has all been seted up with the top and the bottom of second bracket pole to the top of first bracket pole, and the one end of first expansion rod and the one end of second expansion rod all rotate with the inner wall of mounting groove to be connected, one side of first bracket pole is fixed with the last support seat that the equidistance distributes, and one side of second bracket pole is fixed with the lower support seat that distributes, lower support seat and last support seat all are, the cross section that upper and lower support rod and lower support seat are the support seat is the integrative type L and the support seat is closed.
Through above-mentioned technical scheme, utilize the independently expansion performance of first spring to make first support subassembly can automatic expansion for first support subassembly laminating is on the blood vessel inner wall.
Further, the flexible subassembly is including the fixed frame at last branch pipe circumference outer wall bottom and lower branch pipe circumference outer wall top of equidistance, and the inside of fixed frame all is pegged graft and is had the telescopic link, is fixed with the second spring between the one end inner wall of telescopic link and fixed frame, the second support subassembly is including fixing the U type connecting rod at the telescopic link other end, and is located the both ends of two U type connecting rods on the same vertical line and be fixed with third cradling piece and fourth cradling piece respectively.
Through above-mentioned technical scheme, can make the second support subassembly automatic expansion through the independently expansion performance of flexible subassembly, be convenient for laminate the second support subassembly on the blood vessel inner wall.
Further, the anticreep subassembly is fixed in the briquetting of U type connecting rod inner wall including fixing, and one side of two briquetting on same perpendicular line is fixed with same anticreep clamp plate, and the anticreep clamp plate designs into the arc, and the both sides of anticreep clamp plate laminate with one side of third cradling piece and one side of fourth cradling piece mutually, the equidistance distributed's air vent has been seted up on the anticreep clamp plate, and the equidistance distributed's medicine filling groove has been seted up to one side of anticreep clamp plate, the position of medicine filling groove is crisscross with the position of air vent mutually, and the inside packing of medicine filling groove has the second to fill the medicine and carry out physiotherapy to the blood vessel inner wall, effectively reduces thrombosis.
Through above-mentioned technical scheme, prevent that the support main part from appearing becoming flexible and the problem that drops after the degradation, avoid causing other positions of blood vessel to produce the hindrance problem, guaranteed the fixed performance of whole vascular support body to through the second filling medicine.
Further, the first bracket pole, the second bracket pole, the third bracket pole and the fourth bracket pole are all designed into an arc shape and have the same specification, and one side of the first bracket pole, one side of the second bracket pole, one side of the third bracket pole and one side of the fourth bracket pole are all provided with medicine filling holes which are vertically distributed at equal distances, and the inside of the medicine filling holes is filled with first filling medicines.
Through the technical scheme, the physiotherapy effect on the inner wall of the blood vessel is increased, and the problem of thrombus formation is further reduced.
Further, the upper branch pipe, the lower branch pipe, the first support component, the second support component, the anti-falling component and the telescopic component are all made of degradable magnesium alloy materials, and the surfaces of the upper branch pipe, the lower branch pipe, the pressing block, the anti-falling pressing plate, the U-shaped connecting rod and the telescopic component are all coated with a mixed coating capable of reducing degradation speed, and the mixed coating is made of rapamycin and biodegradable high-molecular polymers serving as carriers.
Through the technical scheme, the mixed coating prepared by taking rapamycin and biodegradable high molecular polymer as carriers ensures that the degradation speed of the anti-drop component is obviously smaller than that of the first bracket component and the second bracket component, so that the anti-drop component is abutted on the inner wall of a blood vessel, and the bracket main body is prevented from loosening and falling after degradation.
After adopting the structure, compared with the prior art, the invention has the following advantages:
Firstly, the whole vascular stent body can be self-deployed in the blood vessel, the whole vascular stent body is not required to be deployed by using an expansion mode of a balloon, the problem of deformation can not occur after the whole vascular stent body is expanded, the condition that the strength of the vascular stent is insufficient and the vascular stent is collapsed when the blood vessel is thinned is avoided, the radial shrinkage phenomenon of the whole vascular stent body is prevented, the shape of the whole vascular stent body is prevented from being changed, the subsequent vascular circulation performance is prevented from being influenced, the excessive inflammation or excessive hyperplasia such as neointimal hyperplasia and the like are prevented from being caused, and the problem of thinning of the blood vessel is further restrained;
Secondly, the invention ensures that the contact area between the whole vascular stent body and the inner wall of the blood vessel is larger, and the support treatment is effectively carried out on most positions of the blood vessel, so that the support effect on the blood vessel is better, and the use effect of the whole vascular stent body is improved;
Thirdly, the degradation speed of the anti-falling component is obviously smaller than that of the first bracket component and the second bracket component, the anti-falling component is abutted against the inner wall of the blood vessel, the problem that the bracket main body loosens and falls off after degradation is prevented, the problem that other positions of the blood vessel are blocked is avoided, and the fixing performance of the whole blood vessel bracket main body is ensured.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the invention and together with the description, serve to explain the principles of the invention.
FIG. 1 is a state diagram of the present invention;
FIG. 2 is an overall view of the present invention;
FIG. 3 is a top view of the present invention;
FIG. 4 is a schematic view of the structure of the upper and lower branch pipes of the present invention;
FIG. 5 is a schematic view of a connecting rod according to the present invention;
FIG. 6 is a schematic view of the structure of the upper manifold and the notch of the present invention;
FIG. 7 is a schematic view of a first bracket assembly according to the present invention;
FIG. 8 is a schematic view of the structure of the upper and lower support of the present invention;
FIG. 9 is a schematic view of a first spring and movable seat structure according to the present invention;
FIG. 10 is a schematic view of a second bracket assembly according to the present invention;
FIG. 11 is a schematic view of the structure of the anti-drop pressure plate and the drug filling tank of the present invention;
FIG. 12 is a schematic illustration of a hybrid coating structure of the present invention;
Reference numerals:
1. A blood vessel; 2. a guide tube; 3. an upper branch pipe; 4. a lower branch pipe; 5. an outer tube sleeve; 6. a first bracket assembly; 601. a first expansion rod; 602. a first bracket bar; 603. a second expansion rod; 604. a second bracket rod; 605. a movable groove; 606. a first spring; 607. an upper support seat; 608. a lower support seat; 609. a mounting groove; 610. a movable seat; 7. a second bracket assembly; 701. a U-shaped connecting rod; 702. a third bracket bar; 703. a fourth bracket bar; 8. an anti-drop assembly; 801. pressing blocks; 802. an anti-falling pressing plate; 803. a vent hole; 804. a second fill drug; 805. filling a medicine tank; 9. a connecting rod; 10. a telescoping assembly; 1001. a fixed frame; 1002. a telescopic rod; 1003. a second spring; 11. a notch; 12. filling the medicine hole; 13. a first fill drug; 14. and (5) mixing the coating.
Detailed Description
The present invention will be described in further detail with reference to the drawings and examples, in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
In order to effectively explain the embodiments of the present application, the embodiments of the present application are explained in detail below with reference to the figures.
Referring to fig. 1-12, a fully degradable magnesium alloy cardiovascular stent comprises a vascular stent body and a blood vessel 1 for placing the vascular stent body, wherein the vascular stent body comprises an upper branch pipe 3 and a lower branch pipe 4 which are arranged in the blood vessel 1, a guide pipe 2 is inserted in the middle position of the upper branch pipe 3 and the middle position of the lower branch pipe 4, an outer pipe sleeve 5 is sleeved outside the guide pipe 2, the whole vascular stent is automatically unfolded in a manner of separating from the outer pipe sleeve 5, the operation of expanding the whole vascular stent body in the prior art by utilizing an expanding manner of a balloon is not needed, connecting rods 9 which are distributed in an annular mode at equal intervals are fixed between the bottom of the upper branch pipe 3 and the top of the lower branch pipe 4, notch 11 which are distributed in an annular mode at equal intervals are formed in the circumferential inner wall of the upper branch pipe 3 and the circumferential inner wall of the lower branch pipe 4, the positions of the notch 11 are staggered with the positions of the connecting rods 9, the material utilization rate and the thickness of the upper branch pipe 3 and the lower branch pipe 4 are reduced through the set notch 11, the degradation speed is ensured, the whole vascular stent can be rapidly circulated by blood, and the performance of the whole vascular stent is ensured to be stable through the connecting rods 9 and the lower branch pipe 4.
Referring to fig. 4-9, the first bracket component 6 is designed into a plurality of first bracket components 6, the plurality of first bracket components 6 are distributed between the circumference outer wall of the upper branch pipe 3 and the circumference outer wall of the lower branch pipe 4 in an annular shape at equal distance, the first bracket component 6 comprises a movable groove 605 which is formed at equal distance on the circumference outer wall of the upper branch pipe 3 and the circumference outer wall of the lower branch pipe 4, the inner wall of the movable groove 605 is movably provided with a movable seat 610, the cross section of the movable seat 610 and the cross section of the movable groove 605 are in a T shape, a first spring 606 is fixed between the top of the movable seat 610 and the top of the movable groove 605, one end of each adjacent two movable seats 610 is respectively connected with a first expansion rod 601 and a second expansion rod 603 in a rotating way, one end of each first expansion rod 601 positioned on the same vertical line is provided with the same first bracket rod 602, the same second bracket rod 604 is arranged between one ends of the two second expansion rods 603 positioned on the same vertical line, the top end and the bottom end of the first bracket rod 602 and the top end and the bottom end of the second bracket rod 604 are respectively provided with a mounting groove 609, one end of the first expansion rod 601 and one end of the second expansion rod 603 are respectively connected with the inner wall of the mounting groove 609 in a rotating way, one side of the first bracket rod 602 is fixedly provided with an upper bracket seat 607 which is equidistantly distributed, one side of the second bracket rod 604 is fixedly provided with a lower bracket seat 608 which is equidistantly distributed, the lower bracket seat 608 and the upper bracket seat 607 are arc-shaped, the cross section of the upper bracket seat 607 and the cross section of the lower bracket seat 608 are L-shaped, the upper bracket seat 607 and the lower bracket seat 608 are closed into a whole, when the whole vascular bracket body is unfolded, the first expansion rod 601, the second expansion rod 603 and the movable seat 610 in the first bracket component 6 can move in the movable groove 605 under the expansion action of the first spring 606, thereby pushing the first bracket rod 602 and the second bracket rod 604 to transversely spread, and synchronously driving the upper bracket seat 607 and the lower bracket seat 608 to transversely move and close into a whole, so that the first bracket rod 602, the second bracket rod 604, the upper bracket seat 607 and the lower bracket seat 608 are attached to the inner wall of the blood vessel 1;
The number of the telescopic assemblies 10 is twice that of the first bracket assemblies 6, the plurality of telescopic assemblies 10 are distributed at the bottom of the circumferential outer wall of the upper branch pipe 3 in an annular mode and distributed at the top of the circumferential outer wall of the lower branch pipe 4 in an annular mode at equal intervals, each telescopic assembly 10 comprises a fixed frame 1001 fixed at the bottom of the circumferential outer wall of the upper branch pipe 3 and at the top of the circumferential outer wall of the lower branch pipe 4 at equal intervals, telescopic rods 1002 are inserted into the fixed frames 1001, a second spring 1003 is fixed between one end of each telescopic rod 1002 and one end inner wall of each fixed frame 1001, when the whole vascular bracket body is unfolded, the second spring 1003 is not compressed any more, the telescopic rods 1002 are driven to move in the fixed frames 1001 under the expansion effect of the second spring 1003, and therefore the whole telescopic assemblies 10 are unfolded, and the second bracket assembly 7 is conveniently attached to the inner wall of a blood vessel;
The second bracket component 7, the second bracket component 7 is arranged between one ends of the telescopic components 10 on the same vertical line, the positions of the second bracket component 7 and the positions of the first bracket component 6 are staggered, the second bracket component 7 comprises a U-shaped connecting rod 701 fixed at the other end of the telescopic rod 1002, the two ends of the two U-shaped connecting rods 701 positioned on the same vertical line are respectively fixed with a third bracket rod 702 and a fourth bracket rod 703, when the second spring 1003 expands, the third bracket rod 702 and the fourth bracket rod 703 in the second bracket component 7 can be transversely unfolded, so that the third bracket rod 702 and the fourth bracket rod 703 are attached to the inner wall of the blood vessel 1.
Referring to fig. 1,2, 10-12, the anti-drop component 8 is arranged in the middle of the second bracket component 7, the anti-drop component 8 comprises pressing blocks 801 fixed on the inner wall of the U-shaped connecting rod 701, one side of each pressing block 801 on the same vertical line is fixed with the same anti-drop pressing plate 802, the two sides of each anti-drop pressing plate 802 are designed to be arc-shaped, two sides of each anti-drop pressing plate 802 are attached to one side of the third bracket rod 702 and one side of the fourth bracket rod 703, vent holes 803 distributed equidistantly are formed in each anti-drop pressing plate 802, drug filling grooves 805 distributed equidistantly are formed in one side of each anti-drop pressing plate 802, the positions of the drug filling grooves 805 are staggered with the positions of the vent holes 803, and the second drug filling grooves 804 are filled in the blood vessel bracket, when the blood vessel bracket is used, the whole magnesium alloy blood vessel bracket structure is implanted into a blood vessel 1 by adopting a coronary artery bracket implantation, after the outer tube sleeve 5 and the guide tube 2 are separated from the whole vascular stent body, the whole vascular stent body can be self-unfolded in the blood vessel 1, the pressing block 801 and the anti-drop pressing plate 802 in the anti-drop assembly 8 are synchronously driven to be transversely unfolded, the side surfaces of the first stent assembly 6, the second stent assembly 7 and the anti-drop assembly 8 are annularly attached to the inner wall of the blood vessel 1, the whole vascular stent body is not required to be unfolded by the expanding mode of a balloon in the prior art, deformation problems can not occur after the whole vascular stent body is expanded, the situation that the vascular stent body is not strong enough and collapses when the blood vessel 1 is thinned is avoided, the radial shrinkage phenomenon of the whole vascular stent body is prevented, the follow-up circulation performance of the blood vessel 1 is prevented from being influenced, and the thinning problem of the blood vessel 1 is further restrained.
In the invention, the upper branch pipe 3, the lower branch pipe 4, the first support component 6, the second support component 7, the anti-drop component 8 and the telescopic component 10 are all made of degradable magnesium alloy materials, the surface of the upper branch pipe 3, the surface of the lower branch pipe 4, the surface of the pressing block 801, the surface of the anti-drop pressing plate 802, the surface of the U-shaped connecting rod 701 and the surface of the telescopic component 10 are coated with a mixed coating 14 capable of reducing the degradation speed, the mixed coating 14 is made of rapamycin and a biodegradable high-molecular polymer as carriers, the upper branch pipe 3, the lower branch pipe 4, the first support component 6, the second support component 7, the anti-drop component 8 and the telescopic component 10 which are made of the degradable magnesium alloy materials can achieve the self-degradation performance, and the mixed coating 14 which is made of the rapamycin and the biodegradable high-molecular polymer as the carriers coats the surface of the upper branch pipe 3, the surface of the lower branch pipe 4, the surface of the pressing block 801, the surface of the anti-drop pressing plate 802, the surface of the U-shaped connecting rod and the surface of the telescopic component 10, and the surface of the telescopic component 802, and the anti-drop pressing block 801 are obviously lower than the degradation speed of the first support component 6 and the anti-drop pressing plate 7 and the anti-drop component 7 in the main body 1, and the anti-drop component 1 is degraded by the anti-drop component 1.
Referring to fig. 7,8, 10 and 11, the first bracket bar 602, the second bracket bar 604, the third bracket bar 702 and the fourth bracket bar 703 are all designed to be arc-shaped and have the same specification, and one side of the first bracket bar 602, one side of the second bracket bar 604, one side of the third bracket bar 702 and one side of the fourth bracket bar 703 are all provided with the medicine filling holes 12 which are vertically distributed at equal distances, the first medicine filling 13 is filled in the medicine filling holes 12, the first bracket bar 602, the second bracket bar 604, the third bracket bar 702 and the fourth bracket bar 703 with the same specification form a longitudinal supporting structure, and the physiotherapy effect on the inner wall of the blood vessel 1 is enhanced through the first medicine filling 13 arranged on the surfaces of the first bracket bar 602, the second bracket bar 604, the third bracket bar 702 and the fourth bracket bar 703, so that the problem of thrombus formation is further reduced.
In summary, by means of the above technical solution of the present invention: when in use, a user implants the whole magnesium alloy vascular stent structure into the blood vessel 1 by coronary stent implantation, after the outer tube sleeve 5 and the guide tube 2 are separated from the whole vascular stent body, the first expansion rod 601 and the second expansion rod 603 in the first stent component 6 and the movable seat 610 can move in the movable groove 605 under the expansion action of the first spring 606, so as to push the first stent rod 602 and the second stent rod 604 to transversely expand, synchronously drive the upper stent seat 607 and the lower stent seat 608 to transversely move and close into a whole, and the third stent rod 702 and the fourth stent rod 703 in the second stent component 7 can transversely expand under the expansion action of the second spring 1003 in the telescopic component 10, synchronously drive the pressing block 801 and the anti-release pressing plate 802 in the anti-release component 8 to transversely expand, so that the side surfaces of the first stent component 6, the second stent component 7 and the anti-release component 8 are annularly attached on the inner wall of the blood vessel 1, the whole vascular stent body is not required to be unfolded by adopting the balloon expansion mode in the prior art, the deformation problem of the whole vascular stent body can not occur after the expansion, the physical therapy treatment is carried out through the first filling medicine 13 and the second filling medicine 804, so that the thrombus formation is effectively reduced, the surface of the upper branch pipe 3, the surface of the lower branch pipe 4, the surface of the pressing block 801, the surface of the anti-falling pressing plate 802, the surface of the U-shaped connecting rod 701 and the surface of the telescopic component 10 are coated by the mixed coating 14 which is prepared by adopting rapamycin and a biodegradable high polymer as carriers before the use, the degradation speed of the pressing block 801 and the anti-falling pressing plate 802 is obviously smaller than that of the first stent component 6 and the second stent component 7, so that the anti-falling pressing plate 802 in the anti-falling component 8 is abutted on the inner wall of the blood vessel 1, prevent that the support main part from appearing becoming flexible and coming off after the degradation to through anticreep subassembly 8 butt on the inner wall of blood vessel 1, prevent that the support main part from appearing becoming flexible and coming off after the degradation, when using, reduce material usage and thickness of upper branch pipe 3 and lower branch pipe 4 through notch 11 that sets up, also can make blood circulate upper branch pipe 3 and lower branch pipe 4 fast in the time of guaranteeing degradation speed, and support upper branch pipe 3 and lower branch pipe 4 through connecting rod 9, guarantee the stability performance of whole vascular support.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, and alternatives falling within the spirit and principles of the invention.
Claims (2)
1. A fully degradable magnesium alloy cardiovascular stent body, which is characterized in that the vascular stent body comprises an upper branch pipe (3) and a lower branch pipe (4) which are arranged in a blood vessel (1);
The first bracket components (6) are designed into a plurality of first bracket components (6), and the first bracket components (6) are equidistantly distributed between the circumferential outer wall of the upper branch pipe (3) and the circumferential outer wall of the lower branch pipe (4) in an annular mode;
The number of the telescopic assemblies (10) is twice that of the first bracket assemblies (6), and the telescopic assemblies (10) are distributed at the bottom of the circumferential outer wall of the upper branch pipe (3) in an annular mode at equal intervals and at the top of the circumferential outer wall of the lower branch pipe (4) in an annular mode at equal intervals;
The second bracket component (7) is arranged between one ends of the telescopic components (10) on the same vertical line, and the positions of the second bracket component (7) and the first bracket component (6) are staggered;
The anti-falling assembly (8) is arranged at the middle position of the second bracket assembly (7);
The first bracket component (6) comprises movable grooves (605) which are formed in the circumferential outer wall of the upper branch pipe (3) and the circumferential outer wall of the lower branch pipe (4) at equal intervals, movable seats (610) are movably arranged on the inner walls of the movable grooves (605), the cross sections of the movable seats (610) and the cross sections of the movable grooves (605) are of T shapes, first springs (606) are fixed between the tops of the movable seats (610) and the tops of the movable grooves (605), one ends of two adjacent movable seats (610) are respectively connected with a first expansion rod (601) and a second expansion rod (603) in a rotating mode, one end of each first expansion rod (601) and one end of each second expansion rod (601) on the same vertical line are provided with the same first bracket rod (602), one end of each second expansion rod (603) on the same vertical line is provided with one second bracket rod (604), and the top end and the bottom end of each second bracket rod (604) are respectively provided with a mounting groove (609), and one end of each first expansion rod (601) and one end of each second expansion rod (603) are connected with the inner wall (609) in a rotating mode;
An upper supporting seat (607) which is equidistantly distributed is fixed on one side of the first supporting frame rod (602), a lower supporting seat (608) which is equidistantly distributed is fixed on one side of the second supporting frame rod (604), the lower supporting seat (608) and the upper supporting seat (607) are arc-shaped, the cross section of the upper supporting seat (607) and the cross section of the lower supporting seat (608) are L-shaped, and the upper supporting seat (607) and the lower supporting seat (608) are closed into a whole;
The second bracket component (7) comprises a U-shaped connecting rod (701) fixed at the other end of the telescopic rod (1002), and a third bracket rod (702) and a fourth bracket rod (703) are respectively fixed at two ends of the two U-shaped connecting rods (701) positioned on the same vertical line;
The anti-drop assembly (8) comprises pressing blocks (801) fixed on the inner wall of the U-shaped connecting rod (701), one side of each pressing block (801) on the same vertical line is fixed with the same anti-drop pressing plate (802), the anti-drop pressing plates (802) are designed to be arc-shaped, two sides of each anti-drop pressing plate (802) are attached to one side of each third support rod (702) and one side of each fourth support rod (703), vent holes (803) distributed equidistantly are formed in each anti-drop pressing plate (802), medicine filling grooves (805) distributed equidistantly are formed in one side of each anti-drop pressing plate (802), the positions of the medicine filling grooves (805) are staggered with the positions of the vent holes (803), and second filling medicines (804) are filled in the medicine filling grooves (805);
The first support rod (602), the second support rod (604), the third support rod (702) and the fourth support rod (703) are all designed into arc shapes and have the same specification, and one side of the first support rod (602), one side of the second support rod (604), one side of the third support rod (702) and one side of the fourth support rod (703) are all provided with medicine filling holes (12) which are vertically distributed at equal distances, and the inside of each medicine filling hole (12) is filled with a first filling medicine (13);
The middle position of the upper branch pipe (3) and the middle position of the lower branch pipe (4) are penetrated with guide pipes (2), the outer parts of the guide pipes (2) are sleeved with outer pipe sleeves (5), and the whole vascular stent body is automatically unfolded in a mode of separating from the outer pipe sleeves (5);
Connecting rods (9) which are distributed in an annular mode at equal distances are fixed between the bottom of the upper branch pipe (3) and the top of the lower branch pipe (4), notches (11) which are distributed in an annular mode at equal distances are formed in the circumferential inner wall of the upper branch pipe (3) and the circumferential inner wall of the lower branch pipe (4), and the positions of the notches (11) are staggered with the positions of the connecting rods (9);
The novel high-strength composite material is characterized in that the upper branch pipe (3), the lower branch pipe (4), the first support component (6), the second support component (7), the anti-falling component (8) and the telescopic component (10) are made of degradable magnesium alloy materials, and the surface of the upper branch pipe (3), the surface of the lower branch pipe (4), the surface of the pressing block (801), the surface of the anti-falling pressing plate (802), the surface of the U-shaped connecting rod (701) and the surface of the telescopic component (10) are coated with a mixed coating (14) capable of reducing the degradation speed, and the mixed coating (14) is made of rapamycin and biodegradable high-molecular polymer serving as a carrier.
2. The fully degradable magnesium alloy cardiovascular stent body according to claim 1, wherein the telescopic component (10) comprises a fixed frame (1001) fixed at the bottom of the outer circumferential wall of the upper branch pipe (3) and the top of the outer circumferential wall of the lower branch pipe (4) at equal distances, telescopic rods (1002) are inserted into the fixed frame (1001), and a second spring (1003) is fixed between one end of the telescopic rods (1002) and one end inner wall of the fixed frame (1001).
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| CN202311799480.8A CN117752481B (en) | 2023-12-26 | 2023-12-26 | Completely degradable magnesium alloy cardiovascular stent |
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| CN202311799480.8A CN117752481B (en) | 2023-12-26 | 2023-12-26 | Completely degradable magnesium alloy cardiovascular stent |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110801320A (en) * | 2019-11-15 | 2020-02-18 | 郑州美港高科生物科技有限公司 | Magnesium alloy renal artery stent |
| CN114366402A (en) * | 2022-02-08 | 2022-04-19 | 商丘市第一人民医院 | An intelligent cardiovascular expansion structure |
| CN115317769A (en) * | 2022-09-19 | 2022-11-11 | 李冬冬 | Cardiovascular dilator |
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| US8109987B2 (en) * | 2003-04-14 | 2012-02-07 | Tryton Medical, Inc. | Method of treating a lumenal bifurcation |
| US20090264988A1 (en) * | 2008-04-18 | 2009-10-22 | Medtronic Vascular, Inc. | Stent Graft Delivery System Including Support for Fenestration in Situ and a Mechanism for Modeling |
| CN106726034B (en) * | 2016-12-30 | 2017-10-13 | 河南亚都实业有限公司 | Support for treating hyperplasia of prostate |
| CN107670121A (en) * | 2017-11-09 | 2018-02-09 | 北京赛铂医药科技有限公司 | A kind of absorbable stent and preparation method thereof |
| CN112076013A (en) * | 2020-09-10 | 2020-12-15 | 广州明权科技有限公司 | Shape memory alloy stent for cardiovascular surgery |
| CN112618121B (en) * | 2020-12-16 | 2024-05-24 | 郑州美港高科生物科技有限公司 | Rapamycin drug eluting carotid artery stent |
| CN112618120A (en) * | 2020-12-31 | 2021-04-09 | 郑州美港高科生物科技有限公司 | Completely degradable magnesium alloy cardiovascular stent |
| WO2022178740A1 (en) * | 2021-02-25 | 2022-09-01 | 普利瑞医疗科技（苏州）有限公司 | Peripheral vascular stent, manufacturing method therefor, and application thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110801320A (en) * | 2019-11-15 | 2020-02-18 | 郑州美港高科生物科技有限公司 | Magnesium alloy renal artery stent |
| CN114366402A (en) * | 2022-02-08 | 2022-04-19 | 商丘市第一人民医院 | An intelligent cardiovascular expansion structure |
| CN115317769A (en) * | 2022-09-19 | 2022-11-11 | 李冬冬 | Cardiovascular dilator |
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