CN117618810B - Closed-loop renal nerve ultrasonic ablation system - Google Patents
Closed-loop renal nerve ultrasonic ablation system Download PDFInfo
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- 210000005036 nerve Anatomy 0.000 title claims abstract description 168
- 238000002679 ablation Methods 0.000 title claims abstract description 157
- 230000009471 action Effects 0.000 claims abstract description 52
- 230000007274 generation of a signal involved in cell-cell signaling Effects 0.000 claims abstract description 20
- 230000000694 effects Effects 0.000 claims abstract description 16
- 230000008035 nerve activity Effects 0.000 claims abstract description 11
- 238000002604 ultrasonography Methods 0.000 claims description 20
- 210000002254 renal artery Anatomy 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 10
- 230000008569 process Effects 0.000 claims description 8
- 230000003321 amplification Effects 0.000 claims description 6
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 4
- 230000007383 nerve stimulation Effects 0.000 claims description 3
- 206010020772 Hypertension Diseases 0.000 description 11
- 230000001537 neural effect Effects 0.000 description 9
- 238000010586 diagram Methods 0.000 description 5
- 230000002889 sympathetic effect Effects 0.000 description 4
- 230000004007 neuromodulation Effects 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 239000000219 Sympatholytic Substances 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000008660 renal denervation Effects 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 210000002820 sympathetic nervous system Anatomy 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 206010037211 Psychomotor hyperactivity Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 238000007596 consolidation process Methods 0.000 description 1
- 230000002638 denervation Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 230000001631 hypertensive effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000004126 nerve fiber Anatomy 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000000948 sympatholitic effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/294—Bioelectric electrodes therefor specially adapted for particular uses for nerve conduction study [NCS]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/388—Nerve conduction study, e.g. detecting action potential of peripheral nerves
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/90—Identification means for patients or instruments, e.g. tags
- A61B90/98—Identification means for patients or instruments, e.g. tags using electromagnetic means, e.g. transponders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/04—Constructional details of apparatus
- A61B2560/0462—Apparatus with built-in sensors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
- A61N2007/0021—Neural system treatment
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Abstract
The invention provides a closed-loop renal nerve ultrasonic ablation system, which belongs to the field of medical appliances, and comprises: the device comprises an ablation catheter, a nerve regulation and control module, a circulating pump module and an ultrasonic signal generation module; the ablation catheter is provided with a balloon, a nerve electrode and an ultrasonic transducer; the nerve electrode is used for detecting nerve signals at the action position before and after ablation; the control module is used for judging whether the activity of the nerve signal at the action position before ablation is smaller than a nerve activity threshold, if yes, the ablation is not carried out, otherwise, the circulating pump module and the ultrasonic signal generation module are controlled to ablate the nerve at the action position; judging whether the activity of the nerve signal at the action position after ablation is greater than a preset nerve activity threshold, if so, controlling the circulating pump module and the ultrasonic signal generation module to ablate the nerve at the action position, otherwise, ending ablation. The invention improves the safety and effectiveness of renal nerve ablation.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a closed-loop renal nerve ultrasonic ablation system.
Background
Hypertension remains one of the major risk factors for cardiovascular disease and chronic kidney disease. Despite advances in drug therapy, many patients (about 8% -14% of hypertensive patients) continue to have elevated blood pressure despite reasonable multi-regimen therapy.
Since the beginning of the twentieth century, attempts have been made to modulate the sympathetic nervous system to treat hypertension, including surgical sympatholytic surgery and the use of sympatholytic drugs (central alpha receptor blockers, etc.). The renal sympathetic nervous system has a modulating effect on local and systemic sympathetic nervous activity of the kidneys and is involved in the development and progression of hypertension. The anatomical distribution characteristics of the main trunk of the renal artery enable catheter minimally invasive ablation of renal sympathetic nerve fiber treatment, so intravascular renal sympathetic nerve ablation (Renal Denervation, RDN) treatment aiming at blocking renal sympathetic nerves in recent years gradually becomes a research hot spot in the cardiovascular field.
Ultrasonic renal denervation (UltrasoundRenal Denervation, URDN) is a completely new treatment for refractory hypertension that utilizes ultrasonic energy to act on tissue surrounding the renal arteries to reduce nerve activity and thus blood pressure. The principle of a conventional ultrasound ablation system is shown in fig. 1, and the principle is that a specific excitation frequency of a specific catheter in readable elements on the catheter is read by a reader before ablation or a transducer on the catheter is excited at a low power over a specific frequency range by an ultrasonic source to monitor the response of the transducer to measure the operating frequency of the transducer. And (3) starting to output energy through an ultrasonic source at the acquired specific frequency to perform ablation, monitoring the pressure of liquid in the catheter through a circulating pump module in the ablation process, and circularly cooling the transducer and the vessel wall to reduce the heat of the transducer and the temperature of the renal artery wall.
However, the traditional ultrasonic ablation system directly ablates renal nerves, whether hypertension is caused by overactive nerves is not considered, and when the hypertension is not caused by overactive nerves, the ultrasonic ablation can not effectively treat the hypertension, and potential safety hazards can be caused.
Disclosure of Invention
The invention aims to provide a closed-loop renal nerve ultrasonic ablation system which can improve the safety and effectiveness of renal nerve ablation.
To achieve the above object, the present invention provides a closed loop renal nerve ultrasound ablation system including: the device comprises an ablation catheter, a nerve regulation and control module, a circulating pump module and an ultrasonic signal generation module;
the ablation catheter is provided with a balloon, a nerve electrode and an ultrasonic transducer; the nerve electrode is used for detecting nerve signals at the action position before and after ablation;
the nerve regulation and control module is respectively connected with the nerve electrode and the control module and is used for sending nerve signals at the action position before ablation and nerve signals at the action position after ablation to the control module;
The circulating pump module is connected with the ablation catheter and is used for controlling the pressure and the circulation of liquid in the ablation catheter in the ablation process;
the ultrasonic signal generation module is connected with the ultrasonic transducer and is used for generating an ultrasonic signal in an ablation process so as to control the ultrasonic transducer to generate ultrasonic energy and ablate nerves at the action position;
The control module is further connected with the circulating pump module and the ultrasonic signal generation module, and is used for judging whether the activity of the nerve signal at the action position before ablation is smaller than a preset nerve activity threshold, if yes, the circulating pump module and the ultrasonic signal generation module are controlled to stop running, otherwise, the circulating pump module and the ultrasonic signal generation module are controlled to start running so as to ablate the nerve at the action position; judging whether the activity of the nerve signal at the action position after ablation is greater than a preset nerve activity threshold, if so, controlling the circulating pump module and the ultrasonic signal generation module to start to operate so as to ablate the nerve at the action position, otherwise, controlling the circulating pump module and the ultrasonic signal generation module to stop operating and ending ablation.
Optionally, the nerve regulation module comprises a signal amplifier and a nerve signal converter;
The signal amplifier is connected with the nerve electrode, and the signal amplifying module is used for amplifying the nerve signal detected by the nerve electrode;
The nerve signal converter is respectively connected with the signal amplifier and the control module, and is used for sending the amplified nerve signal to the control module.
Optionally, the neuromodulation module further comprises a neural stimulator; the nerve stimulator is connected with the control module; the control module is also used for controlling the nerve stimulator to emit nerve stimulation energy before or after ablation so as to stimulate nerves at the action position.
Optionally, the number of nerve electrodes is 1 or more.
Optionally, the nerve electrodes are located on either side of the balloon and, when released, are inserted to a depth into the tissue at the site of action or against the renal artery wall.
Optionally, the nerve electrode is a sheet-shaped nerve electrode; the laminar nerve electrode is located on the outer wall of the balloon and, when released, bears against the renal artery wall at the site of action.
Optionally, the catheter is further provided with a plurality of basket; the net baskets are respectively positioned at two sides of the balloon; the nerve electrodes are located on branches of each basket and, when released, rest against the renal artery wall at the site of action.
Optionally, the catheter is further provided with a plurality of auxiliary balloons; the auxiliary balloons are respectively positioned at two sides of the balloon; the nerve electrodes are located on the outer wall of each auxiliary balloon and, when released, rest against the renal artery wall at the site of action.
Optionally, the ultrasonic signal generating module comprises a PWM generating sub-module and a power amplifying sub-module;
The PWM generation submodule is connected with the control module and is used for generating PWM wave signals under the action of the control module;
The power amplification submodule is respectively connected with the PWM generation submodule and the ultrasonic transducer, and is used for amplifying or converting the PWM wave signal into a sine wave to obtain an ultrasonic signal.
Optionally, a chip is arranged in the ablation catheter, and a unique number corresponding to the ablation catheter is prestored in the chip;
The closed loop renal nerve ultrasound ablation system further comprises an identification module; the identification module is respectively connected with the chip and the control module and is used for acquiring the unique number of the ablation catheter before ablation;
the control module is also used for determining the effective duration of the ablation catheter according to the unique number of the ablation catheter, and controlling the ultrasonic transducer to stop running after the ablation time reaches the effective duration of the ablation catheter.
According to the specific embodiment provided by the invention, the invention discloses the following technical effects: according to the method, the nerve signals at the action position are detected before ablation, whether the activity degree of the nerve signals at the action position before ablation is smaller than the preset nerve activity degree threshold value is judged, if yes, it is judged that hypertension is not caused by overactive nerves, ablation is abandoned, unnecessary operation is avoided, safety of renal nerve ablation is improved, and otherwise, the nerves at the action position are ablated. Detecting the nerve signal of the action position again after the ablation is finished, judging whether the activity of the nerve signal of the action position after the ablation is larger than a preset nerve activity threshold, if so, indicating that the nerve signal is still active, and performing the ablation again, otherwise, finishing the ablation, and improving the effectiveness of renal nerve ablation.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions of the prior art, the drawings that are needed in the embodiments will be briefly described below, it being obvious that the drawings in the following description are only some embodiments of the present invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of a conventional ultrasound ablation system;
Fig. 2 is a schematic diagram of a closed loop ultrasound ablation system provided by the present invention.
FIG. 3 is a schematic view of a first ablation catheter with a neural electrode;
FIG. 4 is a schematic view of a second ablation catheter with a neural electrode;
FIG. 5 is a schematic view of a third ablation catheter with a neural electrode;
FIG. 6 is a schematic view of a fourth ablation catheter with a neural electrode;
FIG. 7 is a flow chart of ablation using the closed loop ultrasound ablation system provided by the present invention;
FIG. 8 is a schematic diagram of neural signal overactivity;
Fig. 9 is a schematic diagram of neural signal not overactive.
Symbol description: the device comprises a 1-ablation catheter, a 2-nerve regulation and control module, a 3-control module, a 4-circulating pump module, a 5-ultrasonic signal generation module, a 6-PWM generation sub-module, a 7-power amplification sub-module, an 8-identification module, a 9-sweep frequency module, a 10-user interface, a 11-start-stop control module, a 12-balloon, a 13-nerve electrode, a 14-ultrasonic transducer, a 15-basket and a 16-auxiliary balloon.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The invention aims at the renal nerve ultrasonic ablation, provides a closed-loop renal nerve ultrasonic ablation system, optimizes the safety and effectiveness of clinical application of the renal nerve ultrasonic ablation, can be applied to the field of hypertension treatment caused by overactive renal nerves, and has wider prospects.
In order that the above-recited objects, features and advantages of the present invention will become more readily apparent, a more particular description of the invention will be rendered by reference to the appended drawings and appended detailed description.
As shown in fig. 2, the closed loop renal nerve ultrasound ablation system provided by the present invention includes: ablation catheter 1, nerve regulation and control module 2, control module 3, circulating pump module 4 and ultrasonic signal generation module 5.
As shown in fig. 3 to 6, the ablation catheter 1 is provided with a balloon 12, a nerve electrode 13 and an ultrasonic transducer 14. The nerve electrode 13 is used to detect nerve signals at the site of action before and after ablation. In this embodiment, the number of the nerve electrodes 13 is 1 or more. The following provides four ways of distributing the nerve electrodes 13.
(1) As shown in fig. 3, the nerve electrodes 13 are located on either side of the balloon 12 and are inserted to a depth into the tissue at the site of action or against the renal artery wall when released.
(2) As shown in fig. 4, the nerve electrode 13 is a sheet-like nerve electrode; the laminar nerve electrode 13 is located on the outer wall of the balloon 12 and, when released, abuts the renal artery wall at the site of action.
(3) As shown in fig. 5, the catheter is also provided with a plurality of basket 15; a plurality of basket 15 are positioned on either side of the balloon 12. The basket 15 is formed of two or more branches. The nerve electrodes 13 are located on branches of the respective basket 15, against the renal artery wall at the site of action when released. Specifically, one nerve electrode 13 is provided on each branch.
(4) As shown in fig. 6, the catheter is also provided with a plurality of auxiliary balloons 16. A plurality of auxiliary balloons 16 are located on either side of the balloon 12. The nerve electrode 13 is located on the outer wall of each auxiliary balloon 16 (e.g., against the outer wall of the auxiliary balloon 16) and, when released, abuts the renal artery wall at the site of action.
The nerve regulation and control module 2 is respectively connected with the nerve electrode 13 and the control module 3, and the nerve regulation and control module 2 is used for sending nerve signals at the action position before ablation and nerve signals at the action position after ablation to the control module 3.
Specifically, the neuromodulation module 2 includes a signal amplifier and a neural signal converter.
The signal amplifier is connected with the nerve electrode 13, and the signal amplifying module is used for amplifying the nerve signal detected by the nerve electrode 13.
The nerve signal converter is respectively connected with the signal amplifier and the control module 3, and is used for sending the amplified nerve signal to the control module 3. The neural signal converter may be an analog-to-digital conversion chip (Analog to Digital Converter, ADC), and converts the analog signal into a digital signal and sends the digital signal to the control module 3.
Further, the neuromodulation module 2 further comprises a neurostimulator. The neurostimulator is connected with the control module 3. The control module 3 is also used for controlling the nerve stimulator to send nerve stimulation energy before or after ablation so as to stimulate the nerve at the action position, thereby achieving the purposes of paralysis of the nerve and consolidation of ablation.
The circulating pump module 4 is connected with the ablation catheter 1, and the circulating pump module 4 is used for controlling the pressure and the circulation of liquid in the ablation catheter 1 in the ablation process so as to achieve the effects of cooling the ultrasonic transducer 14 and protecting the vascular wall.
The ultrasonic signal generating module 5 is connected with the ultrasonic transducer 14, and the ultrasonic signal generating module 5 is used for generating an ultrasonic signal in an ablation process so as to control the ultrasonic transducer 14 to generate ultrasonic energy and ablate nerves at the action position.
Specifically, the ultrasonic signal generating module 5 includes a PWM generating sub-module 6 and a power amplifying sub-module 7.
The PWM generation sub-module 6 is connected with the control module 3, and the PWM generation sub-module 6 is used for generating a high-speed PWM wave signal under the action of the control module 3, and the frequency can be 0MHz-10MHz. The chip of the PWM generation sub-module 6 may be a field programmable gate array (Field Programmable GATEARRAY, FPGA) or a digital signal processor (DIGITAL SIGNAL Processing, DSP) capable of generating high-speed stable PWM signals.
The power amplification sub-module 7 is respectively connected with the PWM generation sub-module 6 and the ultrasonic transducer 14, and the power amplification sub-module 7 is used for amplifying or converting the PWM wave signal into a sine wave to obtain an ultrasonic signal.
The control module 3 is also connected with the circulating pump module 4 and the ultrasonic signal generating module 5.
The control module 3 is used for judging whether the activity of the nerve signal at the action position before ablation is smaller than a preset nerve activity threshold value; if yes, judging that the nerve is not overactive and does not need ablation, and controlling the circulating pump module 4 and the ultrasonic signal generating module 5 to stop running so as to avoid unnecessary operation; otherwise, the circulating pump module 4 and the ultrasonic signal generating module 5 are controlled to start to operate so as to ablate the nerve at the action position.
The control module 3 is configured to determine whether the activity of the nerve signal at the location of action after ablation is greater than a preset nerve activity threshold, that is, determine that the nerve signal is overactive before ablation and detect the nerve signal at the distal end side of the ablation catheter 1 after ablation, and determine whether the nerve signal is still overactive; if so, the ablation is insufficient, the ablation needs to be performed again, and the circulating pump module 4 and the ultrasonic signal generating module 5 are controlled to start to operate so as to ablate the nerve at the action position; otherwise, the circulating pump module 4 and the ultrasonic signal generating module 5 are controlled to stop running, and ablation is finished.
As shown in fig. 7, during ablation, the renal artery is measured by contrast, an appropriate ablation catheter 1 is selected, the ablation catheter 1 is placed in the renal artery, each module is connected to the ablation catheter 1, and the circulation pump module 4 is started to pressurize and circulate the ablation catheter 1. The nerve electrode 13 is released, the nerve signal is measured by the nerve electrode 13, whether the nerve signal is overactive at this time is judged, if not, the ablation is ended, if yes, the nerve electrical stimulation (optional) is performed, and then the ablation is performed. And measuring the nerve signal again after the ablation is finished, judging whether the nerve signal is overactive at the moment, if so, carrying out ablation again, if not, carrying out nerve electrical stimulation (optional), judging whether all positions are ablated completely, if not, adjusting the positions to carry out ablation again, and if so, ending the ablation process.
Fig. 8 and 9 are schematic diagrams of nerve signal activity.
Specifically, the control module 3 may be a central processing unit (Central Processing Unit, CPU) or a micro-control unit (MicrocontrollerUnit, MCU) for controlling the operation of all modules, data acquisition, and the like.
Furthermore, a chip, such as an EEPROM, is provided in the ablation catheter 1. The unique number corresponding to the ablation catheter 1 is stored in the chip in advance.
The closed loop renal nerve ultrasound ablation system further includes an identification module 8. The identification module 8 is respectively connected with the chip and the control module 3, and the identification module 8 is used for acquiring the unique number of the ablation catheter 1 before ablation so as to output energy with accurate frequency.
The control module 3 is further configured to determine an effective duration (e.g. 8 hours or other time) of the ablation catheter 1 according to the unique number of the ablation catheter 1, and control the ultrasonic transducer 14 to stop running after the ablation time reaches the effective duration of the ablation catheter 1, so that the ablation catheter 1 fails, and safety is increased. The correspondence between the unique number of the ablation catheter 1 and the effective duration of the ablation catheter 1 is preset.
The closed loop renal nerve ultrasound ablation system further includes a sweep module 9. The sweep frequency module 9 is respectively connected with the ablation catheter 1 and the control module 3. The control module 3 is further configured to control the frequency sweep module 9 to emit a signal in a certain frequency range, such as 0MHz-10MHz, prior to ablation.
To further enhance the safety of the ablation, the closed loop renal nerve ultrasound ablation system further comprises a user interface 10 and a start-stop control module 11. The user can control the starting and stopping of each component through the starting and stopping control module 11 by interactively controlling the control module 3 through the user interface 10.
Compared with the traditional ultrasonic ablation system, the invention adds a nerve signal detection component (nerve electrode 13), and analyzes the necessity of renal nerve ablation and the effectiveness of renal nerve ablation by detecting the nerve signals before and after ultrasonic ablation. Detecting nerve signals before nerve ablation, judging whether the formation of hypertension is caused by overactive nerves, if not, giving up ablation, and avoiding unnecessary operation; if so, an ablative treatment is performed. Detecting nerve signals after nerve ablation, and adjusting treatment parameters and increasing ablation dosage according to feedback of the nerve signals if the nerve signals are still active until the activity of the nerve signals is reduced below a certain threshold. Thereby improving the safety and effectiveness of clinical application of renal nerve ablation.
The principles and embodiments of the present invention have been described herein with reference to specific examples, the description of which is intended only to assist in understanding the methods of the present invention and the core ideas thereof; also, it is within the scope of the present invention to be modified by those of ordinary skill in the art in light of the present teachings. In view of the foregoing, this description should not be construed as limiting the invention.
Claims (7)
1. A closed loop renal nerve ultrasound ablation system, the closed loop renal nerve ultrasound ablation system comprising: the device comprises an ablation catheter, a nerve regulation and control module, a circulating pump module and an ultrasonic signal generation module;
the ablation catheter is provided with a balloon, a nerve electrode and an ultrasonic transducer; the nerve electrode is used for detecting nerve signals at the action position before and after ablation;
the nerve regulation and control module is respectively connected with the nerve electrode and the control module and is used for sending nerve signals at the action position before ablation and nerve signals at the action position after ablation to the control module;
The nerve regulation and control module comprises a signal amplifier, a nerve signal converter and a nerve stimulator;
The signal amplifier is connected with the nerve electrode, and the signal amplifying module is used for amplifying the nerve signal detected by the nerve electrode;
The nerve signal converter is respectively connected with the signal amplifier and the control module and is used for sending the amplified nerve signal to the control module;
the nerve stimulator is connected with the control module;
The control module is also used for controlling the nerve stimulator to send out nerve stimulation energy before or after ablation so as to stimulate the nerve at the action position;
The circulating pump module is connected with the ablation catheter and is used for controlling the pressure and the circulation of liquid in the ablation catheter in the ablation process;
the ultrasonic signal generation module is connected with the ultrasonic transducer and is used for generating an ultrasonic signal in an ablation process so as to control the ultrasonic transducer to generate ultrasonic energy and ablate nerves at the action position;
The control module is further connected with the circulating pump module and the ultrasonic signal generation module, and is used for judging whether the activity of the nerve signal at the action position before ablation is smaller than a preset nerve activity threshold, if yes, the circulating pump module and the ultrasonic signal generation module are controlled to stop running, otherwise, the circulating pump module and the ultrasonic signal generation module are controlled to start running so as to ablate the nerve at the action position; judging whether the activity of the nerve signals at the action position after ablation is greater than a preset nerve activity threshold, if so, controlling the circulating pump module and the ultrasonic signal generation module to start to operate so as to ablate the nerves at the action position, otherwise, controlling the circulating pump module and the ultrasonic signal generation module to stop operating and ending ablation;
The closed loop renal nerve ultrasonic ablation system further comprises a sweep frequency module; the sweep frequency module is respectively connected with the ablation catheter and the control module; the control module is also used for controlling the sweep frequency module to emit signals with a certain frequency range before ablation;
a chip is arranged in the ablation catheter, and a unique number corresponding to the ablation catheter is prestored in the chip;
The closed loop renal nerve ultrasound ablation system further comprises an identification module; the identification module is respectively connected with the chip and the control module and is used for acquiring the unique number of the ablation catheter before ablation;
the control module is also used for determining the effective duration of the ablation catheter according to the unique number of the ablation catheter, and controlling the ultrasonic transducer to stop running after the ablation time reaches the effective duration of the ablation catheter.
2. The closed loop renal nerve ultrasound ablation system of claim 1, wherein the number of nerve electrodes is 1 or more.
3. The closed loop renal nerve ultrasound ablation system of claim 2, wherein the nerve electrodes are located on either side of the balloon and are inserted to a depth into tissue at the site of action or against the renal artery wall upon release.
4. The closed loop renal nerve ultrasound ablation system of claim 2, wherein the nerve electrode is a sheet-like nerve electrode; the laminar nerve electrode is located on the outer wall of the balloon and, when released, bears against the renal artery wall at the site of action.
5. The closed loop renal nerve ultrasound ablation system of claim 2, wherein the catheter is further provided with a plurality of basket; the net baskets are respectively positioned at two sides of the balloon; the nerve electrodes are located on branches of each basket and, when released, rest against the renal artery wall at the site of action.
6. The closed loop renal nerve ultrasound ablation system of claim 2, wherein the catheter is further provided with a plurality of auxiliary balloons; the auxiliary balloons are respectively positioned at two sides of the balloon; the nerve electrodes are located on the outer wall of each auxiliary balloon and, when released, rest against the renal artery wall at the site of action.
7. The closed loop renal nerve ultrasound ablation system of claim 1, wherein the ultrasound signal generation module comprises a PWM generation sub-module and a power amplification sub-module;
The PWM generation submodule is connected with the control module and is used for generating PWM wave signals under the action of the control module;
The power amplification submodule is respectively connected with the PWM generation submodule and the ultrasonic transducer, and is used for amplifying or converting the PWM wave signal into a sine wave to obtain an ultrasonic signal.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113453637A (en) * | 2019-12-26 | 2021-09-28 | 上海微创电生理医疗科技股份有限公司 | Ablation system and nerve detection equipment thereof |
| CN113855173A (en) * | 2020-06-29 | 2021-12-31 | 上海形状记忆合金材料有限公司 | Electrode catheter system |
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| WO2022000178A1 (en) * | 2020-06-29 | 2022-01-06 | 乐普（北京）医疗器械股份有限公司 | Electrode catheter system |
| CN115778522A (en) * | 2022-11-10 | 2023-03-14 | 上海佰川声生命科技有限公司 | Ablation catheter and ablation system |
| CN219042760U (en) * | 2022-11-18 | 2023-05-19 | 深圳市赛禾医疗技术有限公司 | Renal artery sympathetic nerve ultrasonic ablation catheter |
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| CN113453637A (en) * | 2019-12-26 | 2021-09-28 | 上海微创电生理医疗科技股份有限公司 | Ablation system and nerve detection equipment thereof |
| CN113855173A (en) * | 2020-06-29 | 2021-12-31 | 上海形状记忆合金材料有限公司 | Electrode catheter system |
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