CN117599114A - Preparation method of traditional Chinese medicine composition and plaster for treating acute eczema - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating acute eczema and a preparation method of a plaster, and belongs to the technical field of traditional Chinese medicine external products. The invention provides a composition which comprises the following raw material medicines in parts by weight: 6-8 parts of purslane, 6-8 parts of fructus kochiae and 6-8 parts of radix sophorae flavescentis; the plaster is prepared by recovering ethanol from ethanol extract, concentrating water decoction, uniformly mixing the concentrated extract with carbomer, mixing the mixture with functional components, emulsifying, cooling to below 55 ℃, adding lactobacillus bacterial lysate with skin regulating effect, and stirring to room temperature. The external cream disclosed by the invention is mild to skin, easy to apply and good in absorption, can dispel dampness, relieve itching and resist inflammation, is beneficial to mass production, and has stable product quality.

Description

Preparation method of traditional Chinese medicine composition and plaster for treating acute eczema

Technical Field

The invention belongs to the technical field of external traditional Chinese medicine products, and in particular relates to a traditional Chinese medicine composition for treating acute eczema and a preparation method of a plaster.

Background

Acute eczema is a common inflammatory skin disease, and most of clinical manifestations are erythema, pimple or papule, accompanied by edema, and severe cases can appear bleedout. Patients with acute eczema often feel severe itching, are intolerable, and seriously affect the quality of life. If the acute eczema is repeatedly attacked and is not healed after a long time, the eczema is easily converted into chronic eczema, and the treatment is more difficult. The pathogenesis of acute eczema is complex, and modern medicine considers that the acute eczema is mostly caused by both internal factors and external factors, wherein the internal factors comprise heredity, immunity, metabolism, nerve, bacterial and fungal infection and the like; external factors such as environment, climate, diet and exposure to allergens. These factors cause delayed type allergic reactions (anaphylactic reactions) to the body, and various acute eczema symptoms such as erythema, edema and pruritus appear.

At present, the medicines for treating acute eczema mainly comprise external glucocorticoids, external calcineurin inhibitors and antihistamines, but the medicines have adverse reactions such as skin pigment change, skin atrophy, drowsiness, somnolence and the like, and once the medicines are stopped, the diseases are easy to relapse, so that the diseases are chronically prolonged; the traditional Chinese medicine extraction technology comprises water extraction and alcohol precipitation, supercritical extraction, ultrasonic extraction, microwave extraction and the like, and the preparation method from extraction to paste preparation is complicated, has multiple procedures, long working hours and high mass production cost; in the existing method for preparing the traditional Chinese medicine emulsifiable paste, the oil-in-water or water-in-oil mode is generally adopted, and incorrect selection of emulsifying agent, water phase, oil phase, emulsification operation and the like can cause the appearance of uneven product properties, and the cold-hot circulation test or the centrifugal test causes 'demulsification' to influence the smearing and absorption of the product. Therefore, a medicine which is mild to skin, easy to smear, good in absorption, capable of dispelling dampness, relieving itching and resisting inflammation, beneficial to mass production and stable in product quality is needed.

Disclosure of Invention

The invention provides a preparation method of a traditional Chinese medicine composition for treating acute eczema and a plaster, aiming at pathogenesis of the acute eczema, based on understanding of traditional Chinese medicine treatment of the eczema, the following are: the heat and dampness are generated by the pulse, so that sores on the head, face and body are generated, the sores are as pimples, the juice is generated, the heat winner becomes purulent and is accompanied by spasm, and eczema is considered to be caused by the intolerance of intrinsic endowment and rheumatism heat resistance on the skin. Among them, acute patients usually suffer from spleen and stomach damage, spleen failing to transport and get damp-heat, so it is mainly indicated for acute eczema with heat-clearing and damp-excreting effects. Providing the improvement of the extraction rate of purslane flavone, the extraction rate of total saponins of fructus kochiae and the extraction rate of matrine; a preparation method of plaster by adding radix Saposhnikoviae, cortex Dictamni Radicis, fructus forsythiae, scutellariae radix and rhizoma Atractylodis to Chinese medicinal composition for treating acute eczema and adding effective components and lactobacillus cell lysate with skin regulating effect is provided, so as to solve the above problems faced by acute eczema.

The invention aims at providing a traditional Chinese medicine composition for treating acute eczema, and the main technical scheme comprises the following steps: the composition comprises the following raw medicinal materials in parts by weight: 6-8 parts of purslane, 6-8 parts of fructus kochiae and 6-8 parts of radix sophorae flavescentis.

Further, the composition also comprises the following raw medicinal materials in parts by weight: 3-5 parts of radix scutellariae, 4-6 parts of fructus forsythiae, 0.8-1.0 part of cortex dictamni, 3-5 parts of rhizoma atractylodis and 3-5 parts of radix sileris.

Further, the composition is prepared by extracting 3 raw materials of purslane, fructus kochiae and radix sophorae flavescentis with ethanol under reflux, and then decocting with water.

Further, the composition is oily and fine; the particle size of the composition is 0.6-1.5 mu m.

The invention also aims at providing a plaster for treating acute eczema.

Further, the plaster is prepared by mixing the fluid extract of the traditional Chinese medicine composition obtained by recovering ethanol from ethanol extract with the fluid extract obtained by concentrating water decoction.

Further, the plaster is a cream, the cream is prepared by extracting ethanol to obtain an ethanol solution, concentrating a water decoction, uniformly mixing the extract with carbomer, mixing with the effective components, emulsifying, cooling to below 55 ℃, adding lactobacillus lysate with a regulating effect on skin, and stirring to room temperature.

The invention provides a preparation method of the plaster for treating acute eczema.

Further, the preparation method of the plaster for treating acute eczema comprises the following steps:

s1, taking 6-8 parts of purslane, 6-8 parts of fructus kochiae and 6-8 parts of radix sophorae flavescentis, and adding 3-10 times of ethanol with the mass concentration of 50% -80% for reflux extraction for more than 0.5 hours; recovering ethanol to obtain fluid extract 1; standby;

s2, taking 3 medicinal residues of purslane, fructus kochiae and radix sophorae flavescentis, extracting and decocting with water together with 3-5 parts of radix scutellariae, 4-6 parts of fructus forsythiae, 0.8-1.0 part of cortex dictamni, 3-5 parts of rhizoma atractylodis and 3-5 parts of radix sileris, mixing the decoctions, and concentrating under reduced pressure to a proper amount to obtain clear paste 2; standby;

s3, 4-5 parts of glycerin, 3-5 parts of trehalose, 4-5 parts of M68 cetostearyl alcohol, 2-3 parts of propylene glycol, 1-2 parts of pentanediol, 2-3 parts of polyalcohol, 1-2 parts of octanediol, 1-2 parts of butanediol and 0.1-0.2 part of glycerol caprylate; 0.01-0.05 part of ceramide, 0.1-0.15 part of glyceryl monostearate, 0.8-1.0 part of triethanolamine and 0.05-0.1 part of dipotassium glycyrrhizinate, and heating and dissolving the mixture in a container A to 65-90 ℃ to obtain a water phase for later use;

s4, weighing 6-8 parts of stearic acid, 6-8 parts of simethicone, 2-5 parts of squalane, 1.5-2 parts of azone, 2-3 parts of panthenol and 3-4 parts of shea butter; heating and dissolving the mixture in a container B to 65-90 ℃ to obtain an oil phase for later use;

s5, adding the clear paste 1 and the water decoction concentrated solution 2 into the container C, adding 0.05-0.10 part of carbomer, stirring and heating to 65-90 ℃, preserving heat, and uniformly mixing;

s6, adding the S3 water phase into the S5 container C, uniformly mixing, keeping the temperature at 50-90 ℃ and stirring to be uniform;

s7, adding the oil phase S4 into the container C, stirring while adding, and keeping the temperature of the oil phase at 65-90 ℃ during adding; continuously stirring until the oil phase is coagulated after the oil phase is added, and cooling to below 55 ℃;

s8, adding 1-3 parts of lactobacillus lysate into the S7, cooling and stirring to obtain the plaster.

Further, the preparation method of the plaster for treating acute eczema comprises the following steps:

s1, taking 6-8 parts of purslane, 6-8 parts of fructus kochiae and 6-8 parts of radix sophorae flavescentis, and adding 65% ethanol with the mass concentration of 6 times of the weight for reflux extraction for 1 time for 1.5 hours; recovering ethanol to obtain fluid extract 1; standby;

s2, taking 3 medicinal residues of purslane, fructus kochiae and radix sophorae flavescentis, extracting 2 times together with 3-5 parts of radix scutellariae, 4-6 parts of fructus forsythiae, 0.8-1.0 part of cortex dictamni, 3-5 parts of rhizoma atractylodis and 3-5 parts of radix sileris, adding water with the weight being 8 times of the total weight for the first time, and decocting for 1.5 hours; adding water with the weight 6 times of the total weight for the second time, decocting for 1 hour, mixing decoctions, and concentrating under reduced pressure to obtain a proper amount of fluid extract 2; standby;

s3, 4-5 parts of glycerin, 3-5 parts of trehalose, 4-5 parts of M68 cetostearyl alcohol, 2-3 parts of propylene glycol, 1-2 parts of pentanediol, 2-3 parts of polyalcohol, 1-2 parts of octanediol, 1-2 parts of butanediol and 0.1-0.2 part of glycerol caprylate; 0.01-0.05 part of ceramide, 0.1-0.15 part of glyceryl monostearate, 0.8-1.0 part of triethanolamine and 0.05-0.1 part of dipotassium glycyrrhizinate, and heating and dissolving the mixture in a container A to 75-80 ℃ to obtain a water phase for later use;

s4, weighing 6-8 parts of stearic acid, 6-8 parts of simethicone, 2-5 parts of squalane, 1.5-2 parts of azone, 2-3 parts of panthenol and 3-4 parts of shea butter; mixing, heating and dissolving in a container B to 75-85deg.C to obtain oil phase for use;

s5, adding recovered ethanol clear paste 1 and water decoction concentrated clear paste 2 into a container C, adding 0.05-0.10 part of carbomer, stirring and heating to 75-80 ℃, preserving heat for 20-30 minutes, and uniformly mixing;

s6, adding the water phase S3 into the container C of S5, uniformly mixing, keeping the temperature at 75-80 ℃ and stirring for 5-8 minutes to uniformly mix;

s7, adding the oil phase S4 into the container C, stirring while adding, and keeping the temperature of the oil phase at 75-85 ℃; continuously stirring until the oil phase is coagulated after the oil phase is added, and cooling to below 55 ℃;

s8, adding 1-3 parts of lactobacillus lysate into the S7, cooling and stirring to about 40 ℃ to obtain the plaster.

The technical scheme for solving the technical problems is based on the knowledge and treatment principle of traditional Chinese medicine on acute eczema, refers to the research result of modern Chinese medicine theory research on external treatment of internal diseases, breaks through the traditional medication contraindication according to the Chinese medicine theory prescription, and the external cream is mild to skin, easy to apply and absorb, can dispel dampness, relieve itching and resist inflammation, is beneficial to mass production, and has stable product quality.

Among the above raw material components, the drug property characteristics and efficacy of each component of the raw material medicine are as follows:

purslane mainly treats: purslane is annual herb of purslane family, has wide medicinal value, and is often used as a traditional Chinese medicine for treating urination, fever relieving, spasm relieving, antibacterial, insecticidal and the like. Modern pharmacological researches show that purslane has various effects of anti-inflammatory, antioxidant, blood sugar reducing, anti-tumor, immunity enhancing and the like, and the chemical components of purslane mainly comprise polysaccharide, flavone, terpenes, alkaloids, volatile oil, acid substances such as organic acid, unsaturated fatty acid and other bioactive substances, and are mainly used for treating skin diseases such as eczema, pruritus, skin inflammation and the like clinically. The Chinese medicinal composition is firstly carried in the 'herbal channel concentrated injection', is a clinically common Chinese medicament for clearing heat and detoxicating, has the effects of clearing heat and detoxicating, cooling blood and stopping bleeding and stopping diarrhea, and can be used for treating carbuncle, furuncle, eczema, erysipelas and other diseases; "New modified Ben Cao" refers to purslane as the main ingredient of the medicine for treating fistula, wart and mesh, and pounding and wiping; the juice is mainly used for regurgitation, stranguria, golden sore and blood flow, and blood stasis and mass are broken, so that the infant You Liang is provided; the skin is washed with the juice to tighten the lips and facial blebs, ma Han, and the patient is coated with the injection. It is recorded in the book of herbal medicine for food therapy that it is good to apply the paste to horse teeth if it is burnt out. In Yunnan Ben Cao, it is used to treat tinea, etc. by burning ash of herba Portulacae and applying the ointment. Qian jin Fang (Qian jin Fang) records infantile umbilical sores, those with long-term untwisting, purslane, burning and grinding Fu. The materia medica outline is called as furuncle swelling toxin herba leonuri dichotomae and lime dichotomae, which are powder, egg white and Fu; the sores in the ear and the outside are prepared by grinding one or two of the half of the phellodendron bark and one or two of the dry purslane into powder for coating. According to the description of Feng's Bright's book, purslane is cut up, baked, and then added with the medicines of yellow lead, phellodendron bark, dried alum, catechu, etc., so as to prepare the purslane ointment which can treat wind sore of both feet and wind sore of both shoulders and back, and pain and itching to bones. As can be seen, ancient doctors have already found that purslane has the effect of treating eczema, and can be smashed to obtain juice, or burnt to obtain ash, or dried to prepare paste for application on an affected part.

The belvedere fruit mainly treats: is a dry mature fruit of Kochia scoparia (L.) Schrad of Chenopodiaceae, which has pungent, bitter and cold taste, and has main functions and indications of clearing heat and promoting diuresis, dispelling pathogenic wind and relieving itching, and is used for relieving pain of urination, pudendum itch, leukorrhagia, rubella, eczema, skin itch, etc. Modern researches have shown that the triterpene saponin contained in the fructus kochiae is a main bioactive component, has remarkable anti-inflammatory pharmacological action, and is mainly used for treating various skin chronic diseases such as pruritus, eczema and the like. Kochiae fructus is originally carried in Shen nong Ben Cao Jing (Shen nong's herbal), and is listed as an upper product, and has the effects of treating bladder heat, promoting urination, replenishing essence and qi, and the like, and can be used for hearing and improving eyesight, reducing weight and resisting aging after long-term use. The Ming Yi Bie Ji (Ming's miscellaneous records) records that skin is peeled, heat in the skin is removed, malignant sores are dispersed, hernia is generated, yin is strengthened, and the skin is moistened. In Yunnan herbal, it is indicated for excessive heat in urinary bladder, wind washing skin, heat in the channels and collaterals of women, heat in Li Tai, damp-heat in the heat.

The kuh-seng is mainly used for the function: it is originally carried in Shennong Ben Cao Jing (Shennong's herbal meridian), and is also called Hanzhi, di Sophora, ye Sophora japonica, maackia amurensis seed, etc. The kuh-seng is an evaluation of kuh-seng by the name of kuh-seng and the name of kuh-seng, which is the compendium of materia medica, and has the functions of dispelling wind, reducing swelling and eliminating phlegm and toxin. In Yunnan Ben Cao, it is indicated for scabies and scabies with suppurative sore. Can be used for treating skin pruritus, tinea, chronic and chronic skin leukorrhagia, intestinal wind, and hematochezia. The kuh-seng has bitter taste in nature and cold, has the effects of clearing heat and drying dampness, promoting urination, dispelling wind, killing insects and the like, and is used for treating dysentery with heat, hematochezia, jaundice and uroschesis, leucorrhea with reddish discharge, swelling and itching of yin, eczema, sore, skin itch, mange leprosy. It is indicated for both skin itching and female pruritus vulvae with leukorrhagia due to wind-damp invasion of skin, eczema due to damp-heat accumulation and damp-sore. Modern researches have shown that the main ingredients of kuh-seng are matrine and total flavonoids of kuh-seng; matrine has antiinflammatory effect on various acute and chronic inflammations (including immune and non-immune inflammations). Matrine can exert an anti-inflammatory effect by down-regulating the expression of inflammatory cytokines such as Interleukin (IL), tumor necrosis factor-alpha (TNF-alpha), chemokine macrophage inflammatory protein-3 alpha, antibodies, etc., by phagocytes, lymphocytes and injured tissue cells.

The function of the baikal skullcap root is mainly as follows: purging excessive fire, removing dampness and heat, stopping bleeding and preventing miscarriage. For polydipsia due to strong heat, cough due to lung heat, diarrhea due to damp-heat, jaundice, stranguria due to heat, vomiting, epistaxis, metrorrhagia, conjunctival congestion, fetal irritability, carbuncle, swelling and furuncle. Bai Huang is indicated for damp-heat in upper, middle and lower three energizer.

The fructus forsythiae has the main functions of: is dry fruit of fructus forsythiae of Oleaceae. It is mainly indicated for warm heat, erysipelas, macula, carbuncle, ulcer, swelling and toxicity, scrofula and stranguria with urine, and is a key herb for sores.

Cortex dictamni function indication: dispelling wind, eliminating dampness, clearing heat and detoxicating. It is indicated for wind-heat sore, scabies, tinea, skin prurigo, arthralgia due to wind-dampness and jaundice.

The rhizoma atractylodis is mainly used for functional treatment: is rhizome of Atractylodes lancea or Atractylodes lancea in Compositae. For treating excessive dampness, spleen obstruction, listlessness, anorexia, emesis, diarrhea, dysentery, malaria, phlegm retention, edema, common cold, wind-cold-dampness arthralgia, foot flaccidity, and night blindness.

The wind-proof function mainly treats: is root of Ledebouriella root of Umbelliferae plant. Is mainly used for treating exogenous wind-cold, headache, dizziness, strong neck, wind-cold-dampness arthralgia, bone joint ache and limb spasm.

Compared with the prior art, the invention provides a preparation method of a traditional Chinese medicine composition and a plaster for treating acute eczema, which has the following beneficial effects:

1. the traditional Chinese medicine formula products are mostly used for external use, and are lotion, tincture, ointment, gel and the like, and the ointment and the gel are superior to the lotion and the tincture in terms of the action time and the effect of the medicines; the ointment is favorable for skin absorption and repair from the aspects of drug loading and transdermal absorption promotion of the addition of the components, so that the product adopts an ointment formulation.

2. The external cream disclosed by the invention is mild to skin, easy to apply and good in absorption, can dispel dampness, relieve itching and resist inflammation, is beneficial to mass production, and has stable product quality.

Drawings

FIG. 1 shows a preparation method diagram of a plaster for treating acute eczema according to an embodiment of the invention;

FIG. 2 is a diagram showing a comparison of the front and rear of a red sensitive site using a product according to an embodiment of the present invention; wherein A is before use, and B is after use;

fig. 3 shows a skin test experimental chart for relieving skin dryness and increasing moisturizing effect according to an embodiment of the present invention.

Detailed Description

For a better understanding of the present invention, specific examples will be given to further illustrate the invention, however, it should be understood that the illustrated examples are exemplary embodiments and that the invention may be embodied in various forms and should not be limited to the examples set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.

In the examples which follow, the technical means employed are conventional means well known to those skilled in the art, and the reagents and materials of the invention are commercially available or otherwise publicly available, unless otherwise indicated.

The product is prepared by extracting 3 medicinal materials of purslane, fructus kochiae and radix sophorae flavescentis with ethanol under reflux, and then decocting the medicinal residues, 5 medicinal materials of scutellaria baicalensis, fructus forsythiae, cortex dictamni, rhizoma atractylodis, radix sileris and the like with water for 2 times, wherein the water which is 8 times of the weight of the medicinal materials is added for 1.5 hours for the first time; adding water with the weight of 6 times of the weight of the medicinal materials for 1 hour. Mixing the fluid extract of ethanol extraction solution for recovering ethanol with the fluid extract of water decoction, concentrating, and making into cream.

When the product is used for preparing the emulsifiable paste, the ethanol extract is extracted and recycled, the water decoction is concentrated, the emulsifiable paste is uniformly mixed with carbomer, after the emulsifiable paste is mixed with the functional components, the temperature is reduced to below 55 ℃, and the lactobacillus lysate with the skin regulating effect is added and stirred to the room temperature, so that the emulsifiable paste is obtained. The product is easy to be smeared after cold and hot circulation tests and centrifugal tests, and the phenomenon of oil-water separation does not occur.

The preparation steps of the product mainly comprise (see figure 1):

step 1, taking 6-8 parts of purslane, 6-8 parts of fructus kochiae and 6-8 parts of radix sophorae flavescentis, and adding 70% ethanol with the mass concentration of 6 times of the weight for reflux extraction for 1 time for 1.5 hours; recovering ethanol to obtain fluid extract 1; and (5) standby.

Step 2, taking 3 medicinal residues of purslane, fructus kochiae and radix sophorae flavescentis, extracting 2 times together with 3-5 parts of radix scutellariae, 4-6 parts of fructus forsythiae, 0.8-1.0 part of cortex dictamni, 3-5 parts of rhizoma atractylodis and 3-5 parts of radix sileris, adding water with the weight being 8 times of the total weight for the first time, and decocting for 1.5 hours; adding water with the weight 6 times of the total weight for the second time, decocting for 1 hour, mixing decoctions, and concentrating under reduced pressure to obtain a proper amount of fluid extract 2; and (5) standby.

Step 3, 4-5 parts of glycerin, 3-5 parts of trehalose, 4-5 parts of M68 cetostearyl alcohol, 2-3 parts of propylene glycol, 1-2 parts of pentanediol, 2-3 parts of polyalcohol, 1-2 parts of octanediol, 1-2 parts of butanediol and 0.1-0.2 part of glycerol caprylate; 0.01-0.05 part of ceramide, 0.1-0.15 part of glyceryl monostearate, 0.8-1.0 part of triethanolamine and 0.05-0.1 part of dipotassium glycyrrhizinate, and heating and dissolving the mixture in a container A to 75-80 ℃ to obtain a water phase for later use;

step 4, weighing 6-8 parts of stearic acid, 6-8 parts of simethicone, 2-5 parts of squalane, 1.5-2 parts of azone, 2-3 parts of panthenol and 3-4 parts of shea butter; mixing, heating and dissolving in a container B to 75-85deg.C to obtain oil phase for use;

step 5, adding ethanol into the container C to recover the clear paste 1 and the water decoction concentrated solution clear paste 2, adding 0.05-0.10 part of carbomer, stirring and heating to 75-80 ℃, preserving heat for 20-30 minutes, and uniformly mixing;

step 6, adding the water phase in the step 3 into the container C in the step 5, uniformly mixing, keeping the temperature at 75-80 ℃ and stirring for 5-8 minutes to uniformly mix;

step 7, adding the oil phase in the step 4 into the container C, stirring while adding, and keeping the temperature of the oil phase at 75-85 ℃ during adding; continuously stirring until the oil phase is coagulated after the oil phase is added, and cooling to below 55 ℃;

and 8, adding 1-3 parts of lactobacillus lysate into the step 7, cooling and stirring to about 40 ℃ to obtain the lactobacillus lysate.

The invention provides a heating reflux method for extracting purslane, and the extraction rate of purslane flavone is increased. Purslane flavone increases the anti-inflammatory cytokine level, reduces the effect of the anti-inflammatory cytokine level, and is also an important component for playing an anti-inflammatory role.

The invention provides a method for extracting fructus kochiae by heating reflux, the extraction rate of total saponins of fructus kochiae is increased, and the total saponins have in-vitro alpha-glucosidase inhibitory activity.

The invention provides a heating reflux method for extracting kuh-seng, which increases the extraction rate of matrine. Research shows that matrine has good anti-inflammatory and antibacterial effects, and the content of matrine is used as an index for evaluating the quality of the radix sophorae flavescentis in Chinese pharmacopoeia.

The invention provides a product formula which is added with divaricate saposhnikovia root and has the effects of dispelling wind, relieving exterior syndrome, eliminating dampness, relieving pain and relieving spasm.

The invention provides a product formula, wherein the addition of the cortex dictamni has the effects of clearing heat, drying dampness, dispelling wind and detoxifying, and can be used for damp-heat sore toxin, yellow Shui Linli, eczema, rubella, scabies, sore, rheumatic fever arthralgia, jaundice and dark urine and the like. Modern researches have shown that the cortex dictamni contains chemical components such as alkaloids, limonoids and flavonoids, and has antibacterial, anti-inflammatory and antitumor effects.

The invention provides a product formula, which is added with weeping forsythia, has the effects of clearing heat and detoxicating, dispelling wind-heat, detumescence and resolving hard mass, and is mainly used for treating the symptoms of initial warm disease, wind-heat common cold, heat stranguria and pain, damp heat entering ying, scrofula, carbuncle and the like. The research of modern pharmacology shows that weeping forsythia has a plurality of functions of bacteriostasis, antivirus, antioxidation and the like, and is a common medicine for treating sores and scrofula.

The invention provides a formula of the product, which is added with rhizoma atractylodis, and has the effects of eliminating dampness, strengthening spleen, dispelling wind and dispelling cold. Can be used for treating damp obstruction of middle energizer, abdominal distention, diarrhea, edema, tinea pedis , rheumatalgia, etc., and the primordial is Zhuqiheng: zhu is indicated for damp, upper, middle and lower energizer. According to the research of modern pharmacology, rhizoma atractylodis has various effects of bacteriostasis, liver protection, hypoxia resistance, tumor resistance and the like, and is a common medicine for dispelling dampness.

The invention provides ethanol extract and water decoction concentrated extract which are extracted by ethanol and added into carbomer to form a good dispersion system, which is beneficial to quality requirements of product properties, spreadability, stability and the like after emulsification, and is beneficial to skin absorption and even coating.

The invention provides a lipid of squalane closest to sebum of human body in the cream prepared by the product, which has strong affinity, can be integrated with sebum membrane of human body, and forms a natural barrier on the skin surface; promote metabolism of cells and help repair damaged cells. Stimulating the growth of epithelial cells, accelerating the healing time of epidermal wounds and repairing tissue wounds; can be used for treating eczema, sunburn, and infantile diaper rash.

The invention provides the panthenol of the cream prepared by the product has the functions of stimulating the growth of epithelial cells, accelerating the healing time of epidermis wounds and repairing tissue wounds.

The invention provides a method for adding lactobacillus lysate into the product, adjusting the pH value state of skin, and protecting and repairing the skin.

Example 1

In some embodiments of the invention, a cold and hot cycling test of a plaster for treating acute eczema is provided.

The plaster for treating acute eczema is placed at different temperatures and times for cold and hot circulation tests.

Results: the corresponding properties are shown in Table 1.

TABLE 1 Cold and hot cycle test and corresponding Properties at different temperatures and times

Example 2

In some embodiments of the invention, an experiment is provided in which a product for treating acute eczema is observed under a microscope.

Results: smearing the product, wherein the product is oily and fine in character; the particle size was observed under a microscope to be mostly 0.6-1.5. Mu.m.

Example 3

In some embodiments of the invention, an accelerated test of a product for treating acute eczema is provided.

The product is placed in a constant temperature and humidity box, the properties of the product are observed after the product is placed for 6 months under the conditions that the temperature is 40+/-2 ℃ and the relative humidity is 75+/-5%, and the particle size is observed under a microscope.

Results: the character is unchanged; the particle size under the microscope was still largely in the range of 0.6-1.5 μm, unchanged (see Table 2). Because the properties and the particle size are not changed, the product quality is stable.

Table 2 results table of 6 month acceleration test of the product

Example 4

In some embodiments of the invention, a eczema effectiveness test of a product for treating acute eczema is provided.

Test protocol: the test is carried out on the people with light and moderate eczema and no exudative eczema, and whether the product is effective, has irritation and is convenient to smear is observed. The criteria include (significant effect: significant symptom improvement within 7 days, effective symptom improvement within 7 days, no significant improvement: no significant symptom improvement within 7 days, skin pigmentation, irritation, ease of application, and repeated illness within 10 days after treatment). Number of tests: 15 persons.

Results: the total effective rate is 100 percent (15 cases); has obvious effect of 93.4 percent (14 cases); 6.7% effective (1 case); no pigmentation and no recurrence after treatment. No skin irritation; is easy to wipe and is not greasy. The product is effective in treating eczema, and has no repeated treatment and pigmentation, which indicates that the product is effective in treating eczema, has no pigmentation, has no repeated treatment and does not irritate skin.

Example 5

In some embodiments of the invention, a set of test tests for reducing skin irritation is provided.

Test protocol: the red sensitive skin is selected, and the product is used for coating, so that whether the red sensitive condition of the skin is lightened, whether the red sensitive condition of the skin is irritated or not and whether the red sensitive condition of the skin is convenient to coat or not are observed.

The criteria included (effective: improvement of skin redness condition within 15 days: no significant improvement: no relief or no significant improvement of redness symptom within 15 days; simultaneous examination of whether there was skin pigmentation, whether there was irritation, and whether it was convenient to apply). Number of tests: 15 persons.

Results: the total effective rate is 100 percent (15 cases); no pigmentation after application; no skin irritation; is easy to wipe and is not greasy. The product is effective in treating skin red sensitization (see figure 2), and has no pigmentation, which indicates that the product is effective in skin red sensitization, has no pigmentation, and does not irritate skin.

Example 6

In some embodiments of the present invention, skin tests are provided that alleviate skin dryness, increase moisturization.

Test protocol: the product is used for coating dry and sensitive skin, and can be used for observing the dry and chipped skin, whether the moisture of the skin is improved, whether the skin is irritated or not and whether the application is convenient or not. The skin moisture tester was used for testing comparison.

Criteria included (skin moisture test every 2 hours, 4 hours, 6 hours).

Results: has obvious moisturizing effect (see figure 3). No skin irritation after application; is easy to wipe and is not greasy; the product is effective in relieving skin dryness; can improve skin moisture and enhance moisturizing effect.

The foregoing is merely exemplary of the present invention and is not intended to limit the present invention. Various modifications and variations of the present invention will be apparent to those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the scope of claims of the present application.

Claims (10)

1. The traditional Chinese medicine composition for treating acute eczema is characterized by comprising the following raw medicinal materials in parts by weight: 6-8 parts of purslane, 6-8 parts of fructus kochiae and 6-8 parts of radix sophorae flavescentis.

2. The traditional Chinese medicine composition for treating acute eczema according to claim 1, wherein the composition further comprises the following raw medicinal materials in parts by weight: 3-5 parts of radix scutellariae, 4-6 parts of fructus forsythiae, 0.8-1.0 part of cortex dictamni, 3-5 parts of rhizoma atractylodis and 3-5 parts of radix sileris.

3. The traditional Chinese medicine composition for treating acute eczema according to claim 1 or 2, wherein the composition is prepared by extracting 3 medicinal materials of purslane, fructus kochiae and radix sophorae flavescentis with ethanol under reflux, and decocting with water.

4. The traditional Chinese medicine composition for treating acute eczema according to claim 1 or 2, wherein the composition is oily and fine in character; the particle size of the composition is 0.6-1.5 mu m.

5. A plaster for treating acute eczema, which is characterized in that the plaster is prepared from the traditional Chinese medicine composition for treating acute eczema according to claim 1.

6. The plaster for treating acute eczema according to claim 5, wherein the plaster is prepared by combining a clear paste obtained by recovering ethanol from an ethanol extract of the traditional Chinese medicine composition with a clear paste obtained by concentrating a water decoction.

7. The plaster for treating acute eczema according to claim 6, wherein the plaster is a cream, the cream is ethanol extract back ethanol extract, the concentrated water decoction is mixed with carbomer uniformly, and the mixture is further mixed with the functional components, emulsified, cooled to below 55 ℃, added with lactobacillus lysate with regulating effect on skin and stirred to room temperature.

8. A method for preparing a plaster for treating acute eczema, which is characterized in that the plaster is a plaster for treating acute eczema according to claim 6.

9. A method for preparing a plaster for treating acute eczema according to claim 8, comprising the following steps:

s1, taking 6-8 parts of purslane, 6-8 parts of fructus kochiae and 6-8 parts of radix sophorae flavescentis, and adding 3-10 times of ethanol with the mass concentration of 50% -80% by weight for reflux extraction for more than 0.5 hours; recovering ethanol to obtain fluid extract 1; standby;

s2, taking 3 medicinal residues of purslane, fructus kochiae and radix sophorae flavescentis, extracting and decocting together with 3-5 parts of radix scutellariae, 4-6 parts of fructus forsythiae, 0.8-1.0 part of cortex dictamni, 3-5 parts of rhizoma atractylodis and 3-5 parts of radix sileris, mixing the decoctions, and concentrating under reduced pressure to a proper amount to obtain clear paste 2; standby;

s3, 4-5 parts of glycerin, 3-5 parts of trehalose, 4-5 parts of M68 cetostearyl alcohol, 2-3 parts of propylene glycol, 1-2 parts of pentanediol, 2-3 parts of polyalcohol, 1-2 parts of octanediol, 1-2 parts of butanediol and 0.1-0.2 part of glycerol caprylate; 0.01-0.05 part of ceramide, 0.1-0.15 part of glyceryl monostearate, 0.8-1.0 part of triethanolamine and 0.05-0.1 part of dipotassium glycyrrhizinate, and heating and dissolving the mixture in a container A to 65-90 ℃ to obtain a water phase for later use;

s4, weighing 6-8 parts of stearic acid, 6-8 parts of simethicone, 2-5 parts of squalane, 1.5-2 parts of azone, 2-3 parts of panthenol and 3-4 parts of shea butter; heating and dissolving the mixture in a container B to 65-90 ℃ to obtain an oil phase for later use;

s5, adding the clear paste 1 and the water decoction concentrated solution 2 into the container C, adding 0.05-0.10 part of carbomer, stirring and heating to 65-90 ℃, preserving heat, and uniformly mixing;

s6, adding the S3 water phase into the S5 container C, uniformly mixing, keeping the temperature at 50-90 ℃ and stirring to be uniform;

s7, adding the oil phase S4 into the container C, and stirring while adding, wherein the temperature of the oil phase is kept at 65-90 ℃; continuously stirring until the oil phase is coagulated after the oil phase is added, and cooling to below 55 ℃;

s8, adding 1-3 parts of lactobacillus lysate into the S7, cooling and stirring to obtain the plaster.

10. A method for preparing a plaster for treating acute eczema according to claim 9, comprising the steps of:

s1, taking 6-8 parts of purslane, 6-8 parts of fructus kochiae and 6-8 parts of radix sophorae flavescentis, and adding 65% ethanol with the mass concentration of 6 times of the weight for reflux extraction for 1 time for 1.5 hours; recovering ethanol to obtain fluid extract 1; standby;

s2, taking 3 medicinal residues of purslane, fructus kochiae and radix sophorae flavescentis, extracting 2 times together with 3-5 parts of radix scutellariae, 4-6 parts of fructus forsythiae, 0.8-1.0 part of cortex dictamni, 3-5 parts of rhizoma atractylodis and 3-5 parts of radix sileris, adding water with the weight being 8 times of the total weight for the first time, and decocting for 1.5 hours; adding water with the weight 6 times of the total weight for the second time, decocting for 1 hour, mixing decoctions, and concentrating under reduced pressure to obtain a proper amount of fluid extract 2; standby;

s3, 4-5 parts of glycerin, 3-5 parts of trehalose, 4-5 parts of M68 cetostearyl alcohol, 2-3 parts of propylene glycol, 1-2 parts of pentanediol, 2-3 parts of polyalcohol, 1-2 parts of octanediol, 1-2 parts of butanediol and 0.1-0.2 part of glycerol caprylate; 0.01-0.05 part of ceramide, 0.1-0.15 part of glyceryl monostearate, 0.8-1.0 part of triethanolamine and 0.05-0.1 part of dipotassium glycyrrhizinate, and heating and dissolving the mixture in a container A to 75-80 ℃ to obtain a water phase for later use;

s4, weighing 6-8 parts of stearic acid, 6-8 parts of simethicone, 2-5 parts of squalane, 1.5-2 parts of azone, 2-3 parts of panthenol and 3-4 parts of shea butter; mixing, heating and dissolving in a container B to 75-85deg.C to obtain oil phase for use;

s5, adding recovered ethanol clear paste 1 and water decoction concentrated clear paste 2 into a container C, adding 0.05-0.10 part of carbomer, stirring and heating to 75-80 ℃, preserving heat for 20-30 minutes, and uniformly mixing;

s6, adding the water phase S3 into the container C of S5, uniformly mixing, keeping the temperature at 75-80 ℃ and stirring for 5-8 minutes to uniformly mix;

s7, adding the oil phase S4 into the container C, stirring while adding, and keeping the temperature of the oil phase at 75-85 ℃; continuously stirring until the oil phase is coagulated after the oil phase is added, and cooling to below 55 ℃;

s8, adding 1-3 parts of lactobacillus lysate into the S7, cooling and stirring to about 40 ℃ to obtain the plaster.