CN117503630B - Tooth care composition and toothpaste - Google Patents
Tooth care composition and toothpaste Download PDFInfo
- Publication number
- CN117503630B CN117503630B CN202311593625.9A CN202311593625A CN117503630B CN 117503630 B CN117503630 B CN 117503630B CN 202311593625 A CN202311593625 A CN 202311593625A CN 117503630 B CN117503630 B CN 117503630B
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- CN
- China
- Prior art keywords
- hydrated silica
- care composition
- toothpaste
- tooth care
- dextranase
- Prior art date
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- FCBUKWWQSZQDDI-UHFFFAOYSA-N rhamnolipid Chemical compound CCCCCCCC(CC(O)=O)OC(=O)CC(CCCCCCC)OC1OC(C)C(O)C(O)C1OC1C(O)C(O)C(O)C(C)O1 FCBUKWWQSZQDDI-UHFFFAOYSA-N 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical group C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 238000011218 seed culture Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229960002668 sodium chloride Drugs 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 229940079781 sodium cocoyl glutamate Drugs 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229940045944 sodium lauroyl glutamate Drugs 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 description 1
- 229940048109 sodium methyl cocoyl taurate Drugs 0.000 description 1
- IWIUXJGIDSGWDN-UQKRIMTDSA-M sodium;(2s)-2-(dodecanoylamino)pentanedioate;hydron Chemical compound [Na+].CCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC(O)=O IWIUXJGIDSGWDN-UQKRIMTDSA-M 0.000 description 1
- 239000012192 staining solution Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000001040 synthetic pigment Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a tooth care composition and toothpaste, belonging to the technical field of daily chemistry; the tooth care composition provided by the invention comprises hydrated silica, sodium phytate and dextranase, wherein the mass ratio of the hydrated silica to the sodium phytate to the dextranase is as follows: hydrated silica: sodium phytate: dextranase= (5-45): (0.2-3): (0.008-0.06). According to the tooth care composition, proper parts by mass of hydrated silica, sodium phytate and dextranase are selected for compounding, and when the composition is used as an efficacy component and a toothpaste basic formula is prepared into toothpaste in the later period, the obtained toothpaste has high-efficiency whitening and descaling effects, does not damage soft and hard tissues of teeth, and has an excellent plaque-resisting effect; significant effects are achieved. The raw materials of the tooth care composition provided by the invention are simple and easy to obtain, and the tooth care composition can be applied to the preparation of various types of toothpastes, namely, the tooth care composition has high practical application value.
Description
Technical Field
The invention belongs to the technical field of daily chemistry, and particularly relates to a tooth care composition and toothpaste.
Background
From the tissue structure, the tooth consists of enamel, dentin, dental pulp, periodontal tissue and the like; at present, as the attention degree of people on health consciousness is gradually increased, the attention degree on teeth is obviously improved; there is a great deal of attention to both the visual whitening of teeth and the health of the teeth themselves.
Plaque, a soft, unmineralized bacterial population that adheres to each other, or to the surfaces of the dental surfaces, dental or restorations, surrounded by a matrix, is a bacterial biofilm that cannot be rinsed or rinsed off by water; plaque can cause damage to the teeth or gums, causing two of the most common diseases, namely caries and periodontal disease, and the presence of plaque can also seriously affect aesthetics; wherein the dental plaque is a complex three-dimensional structure composed of a plurality of bacteria microorganism cells such as streptococcus, lactobacillus and actinomycetes in the oral cavity and extracellular polymeric matrix, and is adhered and planted on the surface of teeth; dental plaque is composed of a matrix and bacterial cells and contains inorganic components, organic components and functional components. Calculus, also known as tartar, is a milky soft scale that becomes hard due to gradual calcification, is composed of 75% calcium phosphate, 15-25% water, organics, manganese phosphate, calcium mineral, and trace amounts of potassium, sodium, and iron, and is yellow, brown, or black, so calculus can also seriously affect the appearance and is an important causative factor for periodontal disease development. The presence of plaque and calculus on teeth and the presence of salivary membranes provides a good place for the deposition of tooth pigments, and a layer of salivary protein organic membranes are deposited on the surfaces of teeth, so that various colored substances in tea stains, smoke stains and other foods containing pigments can be deposited on the surfaces of teeth and organic membranes by electrostatic force, van der Waals force and short-distance interactions such as hydration, hydrophobic interaction, hydrogen bonding and the like, thus forming exogenous stains which are difficult to remove. Since the presence of calculus, tartar, etc. may cause insufficient whiteness of teeth and affect the health of teeth, how to healthily whiten teeth has become a research hot spot. Moreover, a great number of researches prove that dental plaque is a main factor causing caries and periodontal diseases, and acid-producing bacteria such as streptococcus mutans in the dental plaque produce acid, so that teeth below the dental plaque are demineralized and disintegrated to form caries holes; bacteria and toxins within plaque cause periodontal tissue destruction and alveolar bone resorption. The research shows that dental plaque not only affects the health problem of the oral cavity, but also has a certain relation with cardiovascular diseases, diabetes mellitus, premature low birth weight infants and other systemic diseases. Thus, controlling plaque growth is of great importance in the control of caries and periodontal disease.
The existing tooth whitening methods are generally divided into a physical method and a chemical method; wherein, the physical method whitening mainly achieves the aim of cleaning teeth by the mechanical friction action of the friction agent, and the whitening mainly aims at exogenous pigmentation; the physical method has a certain whitening effect, but has larger damage to teeth, generally shows a tendency that the damage to dentin is larger if the whitening effect is better, and has no obvious effect on controlling the growth of dental plaque. The chemical method is mainly to treat the teeth by peroxide or other oxidizing substances so as to bleach the teeth and obtain the whitening effect; however, the chemical substances added in the chemical whitening generally have a certain irritation, so that the soft tissues of the teeth are damaged.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide the tooth care composition and the toothpaste which can not damage soft and hard tissues of teeth on the basis of achieving the effects of efficiently whitening and descaling teeth, resisting dental plaque and preventing periodontal diseases.
To achieve the above object, in a first aspect of the present invention, there is provided a tooth care composition comprising hydrated silica, sodium phytate and dextranase, wherein the mass ratio of hydrated silica, sodium phytate and dextranase is: hydrated silica: sodium phytate: dextranase= (5-45): (0.2-3): (0.008-0.06); the hydrated silica includes a hydrated silica A and a hydrated silica B, and the average dentin relative abrasion value RDA of the hydrated silica A < the average dentin relative abrasion value RDA of the hydrated silica B.
The tooth care composition provided by the invention is prepared by selecting the hydrated silica, the sodium phytate and the dextranase with proper mass ratio, and the inventor discovers that the composition is used as an efficacy component to prepare the toothpaste with a toothpaste basic formula at the later stage on the basis of the hydrated silica, the sodium phytate and the dextranase with proper mass ratio, the obtained toothpaste has high-efficiency whitening, descaling and cleaning effects, can not cause damage to soft and hard tissues of teeth, and has excellent control effect on the growth of dental plaque, thereby resisting the occurrence of periodontal disease; i.e. a remarkable effect is achieved.
Specifically, the hydrated silica is a mild and neutral soft abrasive, has more proper friction force, can be used for increasing the friction between toothpaste and teeth, and is a basic component for cleaning; the sodium phytate can act on the tooth surface to make the color spots fluffy, disintegrate and float, and the sodium phytate can also protect the tooth enamel from acid dissolution to a certain extent and has the positive effects of resisting dental calculus, and meanwhile, the sodium phytate has the characteristics of naturalness, environmental protection and safety; the dextranase is also called alpha-glucanase (dextranase), is a specific hydrolase for cutting alpha-1, 6 glycosidic bonds in dextran, can decompose alpha-1, 6 glycosidic bonds of polysaccharide in tartar and destroy polysaccharide structure, thereby achieving the effects of effectively removing and inhibiting tartar formation and reducing the combination of pigments and tartar. The inventor researches and discovers that when hydrated silica, sodium phytate and dextranase are selected to be compounded in the mass ratio range of the invention, excellent synergistic effect can be obtained, and the dental caries remover has the characteristics of moderate friction coefficient, no damage to hard tissues of teeth, no damage to soft tissues of teeth, no irritation to oral mucosa and mild and high efficiency on the basis of removing dental plaque, removing pigment and color spots.
As a preferred embodiment of the tooth care composition of the present invention, the mass ratio of hydrated silica, sodium phytate and dextranase in the tooth care composition is: hydrated silica: sodium phytate: dextranase= (15-35): (0.9-2.2): (0.015-0.05).
Preferably, the mass percentage of sodium phytate in the tooth care composition is 3-9%; more preferably, the mass percentage of the sodium phytate is 5-9%.
Preferably, the weight percentage of the dextranase in the tooth care composition is 0.08-0.2%; more preferably, the mass percent of the dextranase is 0.09-0.19%.
The inventors have found that the mass ratio of the components in the dental care composition affects the overall performance of the product, and that when the mass ratio of the components of the dental care composition is further selected to be within the above range, and the mass percentages of sodium phytate and dextranase are within the above range, the overall effect of the resulting product is optimal.
As a preferred embodiment of the tooth care composition of the present invention, the average dentin relative abrasion value RDA of the hydrated silica A is 100.ltoreq.RDA.ltoreq.180, and the average dentin relative abrasion value RDA of the hydrated silica B is 180 < RDA.ltoreq.220.
For example, the average dentin relative abrasion value RDA of the hydrated silica a may be any point value or any range of point values between 100 and 180, such as 100, 110, 120, 130, 135, 140, 145, 150, 155, 160, 165, 170, 175, 180, etc., and the average dentin relative abrasion value RDA of the hydrated silica B may be any point value or any range of point values between 180 < RDA less than 220, such as 181, 185, 190, 195, 200, 205, 210, 215, 220, etc., and is limited to a space, and not listed herein, excellent comprehensive effects can be obtained in the range of average dentin relative abrasion value RDA of the hydrated silica a and the range of average dentin relative abrasion value RDA of the hydrated silica B.
Hydrated silica is also known as silica, different silicas have different RDA values, which refer to the relative wear values of dentin, which represent the type of hydrated silica and also the wear properties of the hydrated silica on teeth; the inventor finds that when hydrated silica with different RDA values is further selected for compounding, a lower damage result of the hard tissues of the teeth can be realized on the basis of ensuring the whitening and cleaning effects; in particular, the combination effect obtained when the hydrated silica of the two RDA value ranges in the invention and even the two RDA value point values in the invention are selected for compounding is better.
As a preferred embodiment of the tooth care composition of the present invention, in the hydrated silica, the mass ratio of the hydrated silica a to the hydrated silica B is hydrated silica a: hydrated silica b= (10-25): (5-10).
As a preferred embodiment of the tooth care composition of the present invention, in the hydrated silica, the mass ratio of the hydrated silica a to the hydrated silica B is hydrated silica a: hydrated silica b= (10-15): 10.
Preferably, in the hydrated silica, the mass ratio of the hydrated silica a to the hydrated silica B is hydrated silica a: hydrated silica b=15: 10.
The inventors have found that the mass ratio of the hydrated silica A and the hydrated silica B specifically used in the hydrated silica also affects the overall properties of the product, and that when the mass ratio of the two kinds of hydrated silica in the hydrated silica is further selected to be within the range given in the present invention, particularly the point value given for the present invention, the overall properties of the resulting product are excellent.
The dextranase used in the invention is the dextranase produced by chaetomium, and the safety evaluation of the dextranase applied in oral products shows that the dextranase has high safety. Specifically, first was a safety assessment of the producer bacteria (chaetomium), showing chaetomium non-pathogenicity after intravenous injection into mice at a dose of 1.5 x 10 6 colony forming units each, and literature searches showed no chaetomium pathogenicity report. The toxicology and toxin assays were followed, and the reverse mutation test (Ames test) showed no mutagenicity; acute toxicity for oral administration: no toxicity was observed when administered at a dose of 1900mgTOS/kg body weight; sub-chronic feeding toxicity for 90 days: no visible deleterious effect levels (NOAEL) exceeding 1900mg TOS/kg-bw/days; aflatoxins B1, B2, G1, G2, ochratoxin a, petechinin, O-methyl-petechinin, T-2 toxin and patulin test negative; the antibacterial activity is negative; again, risk profile, daily intake of dextranase was 0.018 mg TOS per kg-body weight per day. 90-day recessive feeding studies on dextranase concentrate showed no visible detrimental effect levels exceeding 2000 mg (1900 mg TOS)/kg-body weight/day.
In a second aspect of the invention, the invention provides the use of the dental care composition in the preparation of a toothpaste.
The tooth care composition provided by the invention can be used as a main efficacy component or an auxiliary efficacy component to be added into the preparation of toothpaste. The tooth care composition can be used as a main efficacy component for being combined with other basic toothpaste matrixes, so that excellent whitening and cleaning effects and excellent periodontal disease resistance effects are achieved on the premise of not damaging soft and hard tissues of teeth; for example, the tooth care composition provided by the invention can be used as an auxiliary efficacy component to be added into the preparation of toothpaste with a certain efficacy, for example, the toothpaste is added into toothpaste with antibacterial efficacy, so that the prepared toothpaste can achieve excellent whitening effect on the premise of not damaging soft and hard tissues of teeth on the basis of achieving antibacterial efficacy, and the like, which is not listed here, namely, the application range of the tooth care composition provided by the invention is wide, and the tooth care composition can be used for preparing toothpastes with different efficacies.
In a third aspect of the present invention, there is provided a toothpaste comprising a tooth care composition according to the present invention.
As a preferred embodiment of the toothpaste according to the invention, the toothpaste comprises a mass percentage of the tooth care composition of 20-30%.
The inventor researches find that when the mass percentage of the tooth care composition in the invention is 20-30% in toothpaste, the excellent whitening effect can be achieved, and the soft and hard tissues of teeth are not damaged.
As a preferred embodiment of the toothpaste according to the present invention, the toothpaste further comprises at least one of a surfactant, a humectant, a thickener, a stabilizer, deionized water, a taste modifier, an appearance modifier, and a flavor.
The surfactant, the humectant, the thickener, the stabilizer, the taste modifier, the appearance modifier and the essence are substances conventionally used in the toothpaste field. Illustratively, the surfactant is selected from at least one of sodium lauryl sulfate, sodium lauroyl sarcosinate, cocamidopropyl betaine, lauryl glucoside, sodium lauroyl glutamate, potassium cocoyl glycinate, sodium cocoyl glutamate, sunflower glucoside, sodium methyl cocoyl taurate, sodium polyaspartate, rhamnolipid, soapberry extract, and soapberry extract; the humectant is at least one of glycerol, propylene glycol, sorbitol, xylitol and polyethylene glycol; the thickener is at least one selected from xanthan gum, cellulose gum, hydroxypropyl guar gum, carbomer, carrageenan (CHONDRUS CRISPUS), and hydroxyethyl cellulose; the stabilizer is at least one selected from sodium pyrophosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium carbonate and sodium bicarbonate; the taste modifier is at least one selected from saccharin sodium, trichlorogalactose xylitol, stevioside and sodium chloride; the appearance improver is at least one selected from titanium dioxide, natural pigment, synthetic pigment, lake, colored silica particles and pearlescent pigment; the essence is at least one selected from peppermint essence, spearmint essence, wintergreen essence, fruit essence, tea essence, medicinal essence, and essential oil.
In a fourth aspect of the present invention, there is provided a method of preparing the toothpaste, the method comprising the steps of:
(1) Adding deionized water into a premix pan, adding sodium phytate, other water-soluble stabilizer, taste modifier and appearance modifier, stirring for more than 15min until the raw materials are completely dissolved, preparing into aqueous phase solution, and sucking into a paste making machine under stirring;
(2) Weighing part of humectant, and adding into a paste making machine;
(3) Weighing dextranase, pre-dispersing into the rest humectant, stirring, mixing, and adding into paste making machine;
(4) Weighing hydrated silica, a thickener and a surfactant, and uniformly mixing for later use;
(5) Weighing essence for standby;
(6) Preparing paste:
1) Opening a jacket water inlet valve of the paste making pot, and introducing circulating water into the jacket;
2) Turning on a scraper of the paste maker, double stirring (the rotation speed is turned on to the maximum), turning on a vacuum pump, and controlling the vacuum degree to be within the range of-0.04 to-0.08 Mpa to suck all powder in a powder tank;
3) Double stirring for more than 25 min. (①, starting double stirring timing after the vacuum degree reaches-0.092 MPa, ② controlling the temperature of the paste preparation to be below 45 ℃ and timely controlling the opening and closing of cooling water, and not allowing the paste temperature to be too high);
4) Stopping the vacuum pump (continuously stirring and scraping plates), opening the fragrance inlet valve, sucking essence, closing the fragrance inlet valve, starting the vacuum pump after the essence is mixed into the paste, and timing for more than 15 minutes (starting timing after the vacuum degree reaches-0.094 MPa);
5) Stopping double stirring (without stopping a vacuum pump and a scraping plate), controlling the vacuum degree to be not lower than-0.096 Mpa, and continuously vacuumizing and degassing for more than 15 minutes until the paste is smooth, fine, compact and bubble-free;
6) Stopping the paste preparation machine, discharging paste and canning to obtain toothpaste.
Compared with the prior art, the invention has the beneficial effects that:
According to the tooth care composition, proper mass parts of hydrated silica, sodium phytate and dextranase are selected for compounding, the hydrated silica is limited to meet specific requirements, and when the composition is used as an efficacy component and a toothpaste basic formula to prepare the toothpaste in the later period, the obtained toothpaste has a high-efficiency whitening and descaling effect, does not damage soft and hard tissues of teeth, can control the growth of dental plaque and resist the formation of periodontal disease; significant effects are achieved. The raw materials of the tooth care composition provided by the invention are simple and easy to obtain, and the tooth care composition can be applied to the preparation of various types of toothpastes, namely, the tooth care composition has high practical application value.
Drawings
FIG. 1 is a chart showing histological observation of the toothpaste prepared in example 14 in soft tissue injury test.
Detailed Description
For a better description of the objects, technical solutions and advantages of the present invention, the present invention will be further described with reference to the following specific examples.
The reagents, methods and apparatus employed in the present invention are those conventional in the art unless otherwise indicated.
Hydrated silica a: RDA values of 100-180, orasil 116;
hydrated silica B: RDA values 181-220, orasil 107;
dextranase: enzyme activity (U/g) > 1000000, derived from Chaetomium gracile.
Examples 1 to 13 and comparative examples 1 to 7
Inventive examples 1-13 and comparative examples 1-7 provide a tooth care composition having components (parts by mass) as shown in tables 1-2;
TABLE 1
TABLE 2
Examples 14 to 26 and comparative examples 8 to 16
Inventive examples 14-26 and comparative examples 8-16 provided toothpastes having the compositions (mass%) shown in table 3; wherein examples 14-26 and comparative examples 8-16 were identical in the types of selection of the remaining components except for the dental care compositions;
TABLE 3 Table 3
Specifically, the selected surfactant is sodium lauryl sulfate, the humectant is sorbitol, the thickener is xanthan gum, the stabilizer is sodium pyrophosphate, the taste modifier is sodium saccharin, the appearance modifier is titanium dioxide, and the essence is peppermint essence.
Wherein the tooth care compositions in the toothpastes provided in examples 14-26 are the tooth care compositions in examples 1-13, respectively, the tooth care composition in the toothpaste provided in example 14 is the tooth care composition in example 1, the tooth care composition in the toothpaste provided in example 15 is the tooth care composition in example 2, and so on; the tooth care compositions in the toothpastes provided in comparative examples 8 to 14 were the tooth care compositions in comparative examples 1 to 7, respectively, and the tooth care compositions in the toothpastes provided in comparative examples 15 to 16 were the tooth care compositions in example 1;
The toothpaste of examples 14-26 and comparative examples 8-16 were prepared by:
(1) Adding deionized water into a premix pan, adding sodium phytate, other water-soluble stabilizer, taste modifier and appearance modifier, stirring for 20min until the raw materials are completely dissolved, making into aqueous phase solution, and sucking into a paste making machine under stirring;
(2) Weighing 50% of humectant, and adding into a paste making machine;
(3) Weighing dextranase, pre-dispersing into the rest humectant, stirring, mixing, and adding into paste making machine;
(4) Weighing hydrated silica, a thickener and a surfactant, and uniformly mixing for later use;
(5) Weighing essence for standby;
(6) Preparing paste:
1) Opening a jacket water inlet valve of the paste making pot, and introducing circulating water into the jacket;
2) Turning on a scraper of the paste maker, double stirring (the rotation speed is turned on to the maximum), turning on a vacuum pump, and controlling the vacuum degree to be within the range of-0.04 to-0.08 Mpa to suck all powder in a powder tank;
3) Double stirring for 30min. (①, starting double stirring timing after the vacuum degree reaches-0.092 MPa, ② controlling the temperature of the paste preparation to be below 45 ℃ and timely controlling the opening and closing of cooling water, and not allowing the paste temperature to be too high);
4) Stopping the vacuum pump (continuously stirring and scraping plates), opening the fragrance inlet valve, sucking essence, closing the fragrance inlet valve, starting the vacuum pump after the essence is mixed into the paste, and timing for 20min (starting timing after the vacuum degree reaches-0.094 MPa);
5) Stopping double stirring (without stopping a vacuum pump and a scraping plate), controlling the vacuum degree to be not lower than-0.096 Mpa, and continuously vacuumizing and degassing for 20min until the paste is smooth, fine, compact and bubble-free;
6) Stopping the paste preparation machine, discharging paste and canning to obtain toothpaste.
Effect example 1
Effect examples of the present invention the effect of the toothpastes prepared in examples 14 to 26 and comparative examples 8 to 16 was verified; meanwhile, a blank group is arranged in the effect verification, wherein the blank group is an aqueous solution; the effect test section specifically includes the following aspects:
1. Relative Dentin Abrasion (RDA): the RDA value of the toothpaste prepared by the ISO11609-2017 radioactive tracing method is specifically:
1) Tooth sample preparation: using human root dentin extracted from permanent teeth as a matrix, selecting active single teeth during extraction, and respectively mounting the specimens on a mold of cold curing methyl methacrylate resin, so that the cheek surface or the tongue surface is at least 2mm raised and parallel to the surface of the resin;
2) Preparing a reference diluent: the dilution used was a 0.5% carboxymethyl cellulose (7 MF CMC) 6 solution in 10% glycerol;
3) Preparing a friction agent slurry: diluting 10g of a particular batch of calcium pyrophosphate with 50mL of the above reference diluent;
4) Preparing toothpaste slurry: adding 25g of toothpaste into 40mL of water, and stirring to obtain slurry;
5) Pretreatment of tooth specimens: pretreatment is a brushing of the specimen with a slurry of a reference abrasive that does not contain the sample. Using the first dentin specimen, the pretreatment should be performed for 6000 strokes. The next daily pretreatment should be successively reduced by 1000 runs. The pressure at the root of the toothbrush is 150g;
6) Dentin test design: one set of reference slurries (pre-test) was tested after the test and one set of first test slurries was tested. This is followed by a second set of reference slurries (post-test) test. The second set of reference slurries was again used as the pre-test slurry for the next test set. And so on until all test groups have been tested. The pressure of the toothbrush is set to be 150g, and the stroke number of the toothbrush is 1500-3000 (depending on the radioactivity level of the specimen);
7) Sampling toothpaste slurry: aliquots were removed from each slurry immediately after brushing the specimen. The number of aliquots depends on the counting method and equipment, but in general 3mL is sufficient to provide a detectable level of radioactivity. One simple method of extracting a sample is to use a syringe with a blunt needle attached. Care was taken to ensure that no carryover was present between samples. This can be achieved by thoroughly flushing the syringe before drawing the different samples. At the same time, care should be taken to remove an equal amount of sample from each slurry. If a circular plate counter system is used to detect radioactivity, the sample is dried. If the sample needs to be dried, the sample is air-dried for at least 1 hour, and then is put into a forced air oven at 60 ℃ for drying overnight;
8) Obtaining RDA values through different counting methods and correction factors;
the results obtained are shown in Table 4; wherein, the numerical value of RDA reflects the damage of toothpaste to dentin to a certain extent, and when the RDA is below 250, the damage to dentin is not caused;
2. Film cleaning rate (PCR): the film cleaning capability of the prepared toothpaste is tested by adopting a test method for removing exogenous color spots, and the method specifically comprises the following steps:
1) Manufacturing a tooth grinding block: bovine incisors were cut into enamel blocks of approximately 5mm by 2mm in size and embedded in polymethyl methacrylate resin. The labial surface of the tooth enamel is polished by using 180-mesh abrasive paper wetted by water, and the tooth enamel surface with the arc-shaped structure is polished to be flat. After rinsing the sample with water, the enamel surface was polished smooth with 600 mesh sandpaper moistened with water. Washing with deionized water in an ultrasonic bath for 15 minutes;
2) Acid etching: immersing the tooth grinding block in 1% hydrochloric acid, stirring for 60s, taking out, and washing with clear water; then immersing in saturated sodium carbonate solution, stirring for 60s, taking out, and washing with clear water; finally, immersing the mixture into 1% phytic acid solution, stirring for 60s, taking out, and washing with clear water;
3) Preparing a staining solution: dissolving gastric mucin with hot water, adding coffee, soy sauce and black tea, stirring, standing, and cooling. FeCl3 solution stored at 4℃was added before use. The final concentration of each component is 2.5g/L gastric mucin, 4.0g/L coffee, 4.0g/L soy sauce, 4.0g/L black tea and 0.05g/L ferric chloride;
4) Dental plaque attachment and staining of dental mill blocks: streptococcus mutans BNCC336931 is inoculated into BHI (brain heart extract broth) culture medium and cultured at 37deg.C for 24 hr, and the culture is ready for use. Sterilizing the acid etched bovine teeth, placing in 5% sucrose BHI, adding cultured Streptococcus mutans bacterial solution, culturing at 37deg.C for 24 hr, taking out bovine teeth, staining with 1% crystal violet for 10min, and standing for drying. And putting the mixture into a dyeing machine for dyeing for 12 days. Numbering and marking the dyed dental grinding blocks, measuring the color of enamel (L is before tooth play) by using a color difference meter, selecting dental grinding blocks with the L value of 30-40, randomly distributing the dental grinding blocks into a sample group and a control group, and brushing and grinding 8 blocks in each group by using a test object and a control object respectively;
5) Preparation of experimental slurry: preparation of test sample slurry (product): weighing toothpaste and deionized water according to a ratio of 1:1.6 (toothpaste: water), stirring with a glass rod to disperse the toothpaste, and stirring with a magnetic stirrer to obtain homogenate; preparation of a reference substance slurry: preparation of 7% ADA standard calcium pyrophosphate (CPP): preparing 0.5% CMC aqueous solution, respectively weighing appropriate weight of ADA standard calcium pyrophosphate and 0.5% CMC aqueous solution according to the mass ratio of 1:5, mixing, stirring uniformly, and preparing for use at present;
6) Simulating a tooth brushing process: the tooth grinding block is placed into a sample fixing groove of an automatic mechanical tooth brushing machine for fixing, so that the tooth grinding block is higher than the sample fixing groove by about 2mm, and a screw is screwed down for fixing the tooth grinding block. The toothbrush head was mounted so that the bristles vertically contacted the enamel surface, and the total weight of the toothbrush head and the stem was 150g. About 70g of the sample slurry to be measured is weighed and added into a grinding liquid bottle, and the grinding liquid bottle is fixed on a tooth brushing machine, so that the slurry is buried in tooth grinding blocks, and tooth brushing is carried out for 800 times. After the tooth brushing is finished, taking out the tooth grinding block from the tooth brushing machine, washing the tooth grinding block with water, sucking the water with paper towel, and airing;
7) Measuring enamel color after brushing and calculating the difference Δl=l post-npre of the values before and after brushing, respectively, for the experimental and control groups;
8) The PCR value of the test sample was calculated as follows:
Wherein Δl avg represents the average of Δl=l×post-l×pre for the same test sample brushing;
The results obtained are shown in Table 4;
TABLE 4 Table 4
As can be seen from Table 4, when the compositions of the present invention are used, the resulting product has a moderate RDA value and a higher PCR value; namely, the whitening effect is achieved, and meanwhile, the damage to teeth is avoided; specifically, the PCR value of the obtained product is more than 169.98, and the RDA value is less than 197.03; when further selecting hydrated silica: sodium phytate: dextranase= (15-35): (0.9-2.2): (0.015-0.05), the obtained product has better whitening effect and lower damage to teeth, wherein the PCR value is 204.54-206.10, and the RDA value is 178.96-179.33;
As can be seen from examples 14 and examples 19 to 20, the mass ratio of hydrated silica A to hydrated silica B has an effect on the performance of the product, and when it is further preferable that the mass ratio of both is (10 to 25): (5-10), the comprehensive effect of the obtained product is better; as can be seen from example 14 and comparative example 8, when no hydrated silica was added to the tooth care composition, the resulting product hardly exhibited whitening and rubbing effects; as can be seen from examples 14 and comparative examples 12-13, when either only hydrated silica A or only hydrated silica B was added to the dental care composition, the PCR values of the resulting products were increased, but the RDA values were also significantly increased to 283.95, i.e., excessive friction against teeth, which resulted in damage; it can be seen from example 14 and comparative example 14 that the effect of the product on whitening teeth was reduced when the dextranase was changed to cellulase.
Effect example 2
Effect of the invention examples the effect of the toothpaste prepared in example 14, examples 23 to 26, comparative examples 9 to 11 on the removal rate of tartar was verified, specifically comprising the following aspects:
the method for testing the dental calculus removal rate comprises the following steps:
1) Test strain Streptococcus mutans BNCC336931 from Beijing North Biotechnology Co., ltd;
2) Reagent consumable material: brain heart extract broth; sucrose; physiological saline; 0.5mol/L sodium hydroxide solution; consumable and equipment: a water bath kettle; a pipette gun; a 96-well plate; a test tube; an enzyme-labeled instrument; an incubator;
3) Culturing strains:
3.1 seed culture: inoculating BNCC336931 to 5ml BHI broth, and standing and culturing at 37 deg.C under aerobic condition overnight for 20-24 hr;
3.2 fermentation culture: taking a 96-well plate, adding 20 microliters of bacterial liquid (with BHI for regulating the concentration to about 0.6) into each well, adding 180 microliters of BHI containing 5% sucrose, and carrying out aerobic culture at 37 ℃ for 20-24 hours;
4) The evaluation method comprises the following steps:
4.1, discarding the culture solution by using a 1mL pipetting gun, adding 200uL of physiological saline along the hole wall and cleaning for 1 time;
4.2 adding 200uL of 10-fold diluted homogenate supernatant (centrifuging at 5000rpm for 2 min) of toothpaste pre-incubated at 37 ℃ into each hole of the experimental group and the control group, keeping the temperature of the water bath kettle constant at 37 ℃ for 5min (sleeving a fresh-keeping bag water bath), and adding 200uL of physiological saline into the blank group according to the same operation;
4.3 washing 3 times with physiological saline after the heat preservation is finished, adding 200uL of physiological saline each time, and simultaneously washing 3 times with the physiological saline in a blank group and a control group;
4.4, adding 200uL of 0.5mol/L sodium hydroxide solution into each hole after cleaning, stirring for a while by using a gun head or a small spoon to uniformly disperse the bacterial film, and immediately measuring the absorbance value at 550nm by using an enzyme-labeled instrument;
5) And (3) calculating results: calculus removal rate= [ (absorbance of blank group-absorbance of experimental group or control group)/absorbance of blank group ] ×100%.
The results obtained are shown in table 5,
TABLE 5
The obtained results show that the toothpaste prepared by adopting the technical scheme of the invention has excellent tartar removal rate, wherein the tartar removal rate is more than 29%.
Effect example 3
Effect example of the present invention the toothpaste prepared in example 14 was tested for soft tissue injury, specifically: the prepared toothpaste is directly contacted with the buccal mucosa of the golden-yellow mice so as to evaluate the irritation of the toothpaste to the oral mucosa of the mice. The test is carried out according to the method in the pharmaceutical industry standard YY/T0127.13-2018 (oral mucosa irritation test part 13 of oral medical instrument biological evaluation) of the people's republic of China; specifically, taking 9 golden mice, dividing the golden mice into 3 groups (example 14, blank group and control group), after general anesthesia, cleaning left and right cheek mucous membranes, checking whether the cheek mucous membranes are abnormal or not, contacting the right cheek mucous membrane to prepare a toothpaste sample, contacting the left cheek mucous membrane with the control sample, fully contacting the sample with the cheek mucous membrane for 10min, removing the sample, repeating the stimulating step for 4 times per hour, visually observing the contact part of the tested sample and the mucous membrane, and recording the scoring value; after the sample is in last contact with the mucous membrane for 24 hours, performing histological evaluation on the contact part of the sample to be tested, and recording scoring values, wherein an oral mucosa scoring system is shown in tables 6-8;
TABLE 6 oral mucosa response scoring System
TABLE 7
TABLE 8 oral mucosa tissue reaction fractionation
| Response scoring | 0～4 | 5～8 | 9～11 | 12～16 |
| Grade | Without any means for | Mild and mild | Moderate degree | Heavy weight |
The three golden yellow mice oral mucosa histological photographs after 24 hours of administration of the toothpaste of example 14 are shown in fig. 1, and it can be seen from fig. 1 that the toothpaste of example 14 of the present invention does not damage the soft tissues;
Finally, it should be noted that the above-mentioned embodiments illustrate rather than limit the scope of the invention, and that those skilled in the art will understand that changes can be made to the technical solutions of the invention or equivalents thereof without departing from the spirit and scope of the technical solutions of the invention.
Claims (5)
1. A tooth care composition, characterized in that the tooth care composition consists of hydrated silica, sodium phytate and dextranase, wherein the mass ratio of the hydrated silica, the sodium phytate and the dextranase is as follows: hydrated silica: sodium phytate: dextranase= (5-45): (0.2-3): (0.008-0.06);
The hydrated silica comprises hydrated silica A and hydrated silica B, wherein the average dentin relative abrasion value RDA of the hydrated silica A is less than the average dentin relative abrasion value RDA of the hydrated silica B;
the average dentin relative abrasion value RDA of the hydrated silica A is more than or equal to 100 and less than or equal to 180, and the average dentin relative abrasion value RDA of the hydrated silica B is more than 180 and less than or equal to 220;
In the hydrated silica, the mass ratio of the hydrated silica A to the hydrated silica B is hydrated silica A: hydrated silica b= (10-25): (5-10).
2. The tooth care composition according to claim 1, characterized in that in the tooth care composition, a mass ratio of hydrated silica, sodium phytate and dextranase is: hydrated silica: sodium phytate: dextranase= (15-35): (0.9-2.2): (0.015-0.05).
3. Use of a dental care composition according to any one of claims 1-2 for the preparation of a toothpaste.
4. A toothpaste comprising a surfactant, a humectant, a thickener, a stabilizer, deionized water, a taste modifier, an appearance modifier, a flavour and a tooth care composition according to any one of claims 1 to 2;
The surface active agent is sodium lauryl sulfate, the humectant is sorbitol, the thickener is xanthan gum, the stabilizer is sodium pyrophosphate, the taste modifier is saccharin sodium, the appearance modifier is titanium dioxide, and the essence is peppermint essence.
5. The toothpaste according to claim 4, wherein the mass percentage of the tooth care composition in the toothpaste is 20-30%.
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| JPH10298049A (en) * | 1997-04-30 | 1998-11-10 | Lion Corp | Suppressant for formation of bacterial plaque and composition for oral cavity |
| US7306788B2 (en) * | 2004-11-24 | 2007-12-11 | J.M. Huber Corporation | High-cleaning/moderate abrasive silica materials and dentifrice containing such materials |
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| US7270803B1 (en) * | 2006-03-23 | 2007-09-18 | J.M. Huber Corporation | High-cleaning, low abrasion, high brightness silica materials for dentrifices |
| US20080138298A1 (en) * | 2006-12-12 | 2008-06-12 | The Procter & Gamble Company | Oral care compositions comprising zinc and phytate |
| JP5374863B2 (en) * | 2007-12-05 | 2013-12-25 | ライオン株式会社 | Oral composition and method for producing oral composition |
| US20140271900A1 (en) * | 2013-03-15 | 2014-09-18 | J.M. Huber Corporation | High Cleaning Silica with Low Abrasion and Method for Making Same |
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| BR112023016180A2 (en) * | 2021-02-11 | 2023-12-12 | Evonik Operations Gmbh | NON-POROUS AMORPHOUS SILICA |
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| CN115813799A (en) * | 2022-12-09 | 2023-03-21 | 云南白药集团健康产品有限公司 | A kind of whitening tooth care composition and its application in oral care products |
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| WO2016062450A1 (en) * | 2014-10-22 | 2016-04-28 | Henkel Ag & Co. Kgaa | Oral and dental care and cleaning agent having improved polishing agent combination |
| CN106619187A (en) * | 2017-01-24 | 2017-05-10 | 广州薇美姿实业有限公司 | Composition for preventing dental calculus and application |
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