CN117481340A - Special medical food for people with hypertension constipation and preparation method thereof - Google Patents

Abstract

The invention discloses a special medical food for people with hypertension and constipation, which comprises the following components in parts by weight: 30-50 parts of potato residue extract, 5-15 parts of resistant dextrin and 30-50 parts of fruit and vegetable powder. The potato residue extract is an aqueous extract of potato residue. The invention also discloses a preparation method of the special medical food. The special medical food component not only comprises water-soluble dietary fibers extracted from food materials, but also comprises vegetables and fruits rich in water-soluble dietary fibers and insoluble dietary fibers and having the effect of relaxing bowel, and can provide rich nutrition and excellent health care functions for organisms, and all the components are mutually matched in a synergistic way, so that the blood pressure value of patients is obviously reduced.

Description

A kind of special medical food for people with hypertension and constipation and its preparation method

Technical field

The invention belongs to the field of special medical food, and specifically relates to a special medical food for people with hypertension and constipation and a preparation method thereof.

Background technique

According to the latest "China Guidelines for the Prevention and Treatment of Hypertension" (revised version 2018), hypertension is defined as having blood pressure values higher than normal three times within the same day without the use of antihypertensive drugs, that is, systolic blood pressure ≥140mmHg and (or) Diastolic blood pressure ≥90mmHg.

Hypertension does not have obvious symptoms in the early stages. Common symptoms include dizziness, headache, stiff neck, fatigue, heart palpitations, etc. However, long-term hypertension can cause damage to blood vessels, especially to the heart, brain, and kidneys, which is very serious. The damage to the heart is that the heart will become diseased and cause stenosis or myocardial ischemia will cause angina pectoris. The damage to the brain is cerebral hemorrhage, cerebral infarction and transient cerebral ischemia.

It is worth noting that high blood pressure can easily lead to constipation. First, long-term fluctuations in blood pressure can easily lead to hardening of small arteries throughout the body, inducing chronic ischemia in intestinal smooth muscles, thereby weakening gastrointestinal motility and leading to constipation; second, nifedipine and ammonia are commonly used in patients with hypertension. Antihypertensive drugs such as dipine and nimodipine have side effects of slowing down intestinal peristalsis and causing constipation; third, patients with hypertension are prone to stress and anxiety, which can lead to constipation. On the contrary, constipation can easily cause blood vessels to be cleared of waste more slowly, thereby aggravating the increase in blood pressure and further causing various diseases, such as hemorrhoids, abdominal hernia, colon polyps, colon cancer, liver damage, etc.

Hypertension is a "lifestyle disease". The triggering factors include a high-sodium and low-potassium diet, excessive drinking, long-term mental stress, insufficient physical activity, etc. Other risk factors include age, family history of hypertension, combined diabetes, and dyslipidemia. . Therefore, lifestyle intervention can reduce blood pressure and the risk of disease to a certain extent, including eating potassium-rich foods, reducing mental stress, exercising appropriately, quitting smoking and drinking, etc.

The current treatment methods for hypertension are mainly drug therapy and surgical treatment. Among them, commonly used drugs used to treat hypertension include calcium channel blockers, beta blockers, ACEI, ARB, etc. These drugs can lower blood pressure and can also reduce the incidence of heart disease and stroke; for Patients with refractory hypertension or patients with other heart diseases can be treated with surgery. Drug therapy has a faster onset of effect and can control the patient's hypertension in a shorter period of time. However, drugs are often more toxic and have side effects, which can bring extra burden to the body of patients with hypertension; and surgery The treatment method carries certain risks and may cause certain damage to the human body, especially for older hypertensive patients with underlying diseases.

Contents of the invention

In view of the deficiencies in the above-mentioned prior art, the present invention provides a special medical food for people with hypertension and constipation and a preparation method thereof. Based on the efficacy, nutrition, taste, cold and heat balance of each component, the present invention develops food-grade raw materials, low antigenicity, safe and efficient, and suitable for a wide range of people, special medical food, which not only significantly reduces the blood pressure of patients, but also has the function of laxative and laxative. , relieve constipation in patients.

The specific technical solutions are as follows:

One of the objects of the present invention is to provide a special medical food for people with hypertension and constipation, which includes the following components in parts by weight:

30 to 50 parts of potato residue extract, 5 to 15 parts of resistant dextrin, and 30 to 50 parts of fruit and vegetable powder.

Wherein, the potato residue extract is a water extract of potato residue, the main component of which is water-soluble dietary fiber.

Wherein, the potato residue refers to the waste produced after potato produces starch.

The potato residue water extract and resistant dextrin in this combination are water-soluble dietary fibers. Compared with insoluble dietary fibers, water-soluble dietary fibers have less irritation to the gastrointestinal tract, better gastrointestinal tolerance, and are more effective. Yes, it is the main functional ingredient in this special medical food. In addition to water-soluble dietary fiber, fruit and vegetable powder also contains a large amount of insoluble dietary fiber. Each component cooperates with each other to achieve a perfect combination of the two dietary fibers, which significantly lowers the patient's blood pressure and also acts as a laxative. Effect.

Water-soluble dietary fiber is intertwined with carbohydrates such as starch in the gastrointestinal tract, delaying the absorption of the latter, thereby controlling the increase in blood sugar levels after meals; and there are many active groups on the surface of water-soluble dietary fiber, and these active groups can Chelate some organic molecules such as cholesterol and bile acids to change the metabolic pathway of cholesterol, excrete excess cholesterol from the body, keep blood vessels soft and elastic, and have the effect of preventing and treating cardiovascular and cerebrovascular diseases such as atherosclerosis, coronary heart disease, and hypertension. . At the same time, resistant dextrin, as a very soluble dietary fiber, can significantly reduce blood cholesterol and maintain postprandial blood sugar stability. It can also improve the utilization of nutrients and promote the absorption of trace elements such as calcium, iron, and zinc. absorb.

Further, the fruit and vegetable powder includes the following components in parts by weight:

30 to 50 parts of apple powder, 30 to 50 parts of banana powder, 30 to 50 parts of sweet potato powder, 20 to 40 parts of orange powder, 5 to 10 parts of konjac powder, and 15 to 35 parts of tomato powder.

Apples, bananas, oranges, and tomatoes contain more potassium ions, which can antagonize the effect of sodium ions on constricting blood vessels. They can combine with excess sodium in the body to be excreted from the body, maintaining sodium and potassium balance and acid-base balance in the body, so as to stimulate the nerves. Muscles remain normal and myocardial contractions are coordinated to prevent and treat high blood pressure; sweet potatoes contain folic acid and potassium needed by the human body, which can maintain the acid-base balance of body fluids, lower blood pressure, and prevent arteriosclerosis and other cardiovascular diseases; oranges can increase The body's resistance, increasing the toughness of capillaries, lowering cholesterol, preventing and treating hyperlipidemia, hypertension, arteriosclerosis, etc.; Lycopene in tomatoes can promote cholesterol excretion, prevent thrombosis, and reduce complications of hypertension.

Among them, the glucomannan content of the konjac powder is preferably 80 to 95%.

The main component of konjac is glucomannan, which is a soluble dietary fiber. Studies have shown that konjac has the effect of lowering blood pressure, lowering blood lipids and lowering postprandial blood sugar.

The recommended dosage of the above-mentioned special medical food is 20 to 30 grams each time, once a day.

The second object of the present invention is to provide a method for preparing the above-mentioned special medical food for people with hypertension and constipation, including a method for preparing potato residue extract, which includes the following steps:

(1) Impurity removal: Use amylase to remove starch from potato residue; then soak it in alkali or alkaline salt solution to remove impurities;

(2) Crushing: dry the impurity-removed potato residue and then crush it;

(3) Extraction: Use citric acid as a co-solvent to extract the crushed potato residue with water;

(4) Alcohol precipitation: Use ethanol to precipitate the leach solution.

Further, in step (1), the amylase is α-amylase, preferably a mesophilic α-amylase.

Specifically, the enzymatic hydrolysis conditions are preferably: mix potato residue and water according to a mass ratio of 1: (15~35), add 5~10 U/g α-amylase based on the mass of potato residue, and stir and hydrolyze at 60°C~70°C. 0.5~2.5h, remove residual starch.

Specifically, before starch removal, the potato residue is preferably thoroughly washed with water.

Further, in step (1), after removing starch, soak the potato residue with 1~5wt% NaHCO ₃ solution for 0.5~2.5h to remove residual proteins, lipids, etc.

Specifically, during the impurity removal process of soaking the NaHCO ₃ solution, intermittently stirring can be performed.

Specifically, after soaking, the potato residue is preferably washed with clean water.

Further, in step (2): after drying, coarse grinding is performed first, and then the coarse powder is ultra-finely ground.

Further, in step (3): add 2~6wt% citric acid solution to the potato residue powder, and microwave it at 250~550W for 2~6 minutes; the mass ratio of potato residue powder to citric acid solution is 1: (30~50) .

Specifically, after the extraction is completed, the supernatant is obtained by centrifugation, which is the extraction liquid. The centrifugation conditions are preferably 2500-4500 rpm for 5-10 minutes.

Further, in step (4): add ethanol to the extract and then refrigerate at 0~4°C for 10~30 hours.

Specifically, it is preferred to concentrate the leach liquid obtained in step (3) to 1/4 to 1/8 of the original volume before alcohol precipitation, and then add 4 to 8 times the volume of absolute ethanol to the concentrated liquid. .

Specifically, after alcohol precipitation, centrifuge to obtain a precipitate. The precipitate is washed 2 to 4 times with ethanol, dried and pulverized to obtain potato residue extract powder. The centrifugation conditions are preferably 2500-4500 rpm for 5-10 minutes. The drying method is preferably freeze-drying. The potato residue extract is preferably pulverized into coarse powder with a particle size of 60 to 90 mesh.

Further, the prepared dried potato residue extract powder, resistant dextrin powder, and fruit and vegetable powder are mixed according to the formula proportion and ground into a mixture of ultrafine powder with a particle size of 1 to 10 μm. The ultrafine powder of the mixture is packaged, and the packaging specification is 20~50g/bag.

Specifically, the preparation method of apple powder is preferably as follows:

Select high-quality apples with thin skin and thick flesh that are fully mature, clean them, peel and core them, and cut them into 7~8 mm thick round slices. Place the sliced apple slices in a 3~5wt% saline solution to protect the color. , to avoid oxidation and turning black, vacuum freeze-drying and then grind it into coarse powder with a particle size of 60~90 mesh.

Specifically, the preparation method of banana powder is preferably as follows:

Select a fully ripe banana, cut it in half, apply a layer of lemon juice on the cut surface, then peel it, apply a layer of lemon juice on the peeled area, vacuum freeze-dry it and crush it into a coarse powder with a particle size of 60 to 90 mesh.

Specifically, the preparation method of sweet potato flour is preferably as follows:

Select high-quality sweet potatoes with no erosion, no spots, clean them, peel them, slice them, put them in the drying room, and bake them at 70~90°C until they are crispy. Always drain the moisture during the drying process. After drying, grind it into coarse powder with a particle size of 60~90 mesh.

Specifically, the preparation method of orange powder is preferably as follows:

Select fresh and high-quality sweet oranges, clean them, peel them, slice them, vacuum freeze-dry them, and crush them into coarse powder with a particle size of 60 to 90 mesh.

Specifically, the preparation method of tomato powder is preferably as follows:

Select high-quality tomatoes with high maturity, clean them, peel them, slice them, vacuum freeze-dry them, and crush them into coarse powder with a particle size of 60 to 90 mesh.

The beneficial effects of the present invention are as follows:

1. The present invention uses waste potato residue as raw material to extract water-soluble dietary fiber. The potatoes produced in my country every year are mainly used for commercial sales and the production of potato starch. A large amount of potato residue is produced during the production of starch. After being discarded, it is easy to ferment under the action of microorganisms. After deterioration and putrefaction, stench is produced, and directly burying it will seriously harm the local environment. The invention turns waste potato residue into treasure, avoids waste of resources, and protects the ecological environment at the same time.

2. The special medical food of the present invention is specially designed for people with hypertension and constipation. Its ingredients not only include water-soluble dietary fiber extracted from food raw materials, but also are rich in water-soluble dietary fiber and insoluble dietary fiber. It has a significant laxative effect. It can also provide the body with vegetables and fruits with rich nutrition and excellent health care functions. The perfect combination of the two dietary fibers can significantly lower and stabilize blood pressure, and can also have a laxative effect.

3. The special medical food of the present invention is food-grade raw materials, has low antigenicity, is safe and efficient.

The ingredients of the special medical food of the present invention do not contain traditional Chinese medicine, are safer, and are widely applicable to various types of patients with hypertension and constipation and high-risk groups; the various raw materials used in the special medical food of the present invention are pure natural foods or natural extracts thereof. It has no toxic or side effects on the human body, does not cause diarrhea, is safe and reliable, and can be taken by patients with high blood pressure and constipation for a long time.

4. The present invention uses resistant dextrin instead of conventional maltodextrin. In addition to having the taste of maltodextrin, it also increases the unique effects of resistant dextrin.

5. The present invention selects raw materials and combines them with advanced technological processes to fully retain the nutrients in the original food materials, and to fully release the active ingredients in the cells of the raw materials, so that they can be digested, absorbed and utilized by the human body to the greatest extent.

Detailed ways

The principles and features of the present invention are described below with examples. The examples are only used to explain the present invention and are not intended to limit the scope of the present invention.

In a specific embodiment, konjac powder is commercially available, and its glucomannan content is 93%.

In the specific embodiment, the medium-temperature α-amylase was purchased from Nanjing Tongying Biotechnology Co., Ltd. and was food grade.

Example 1

A special medical food for people with hypertension and constipation, consisting of the following components in parts by weight: 30 parts of potato residue extract, 5 parts of resistant dextrin, and 50 parts of fruit and vegetable powder.

Among them, the fruit and vegetable powder consists of the following components in parts by weight: 50 parts of apple powder, 30 parts of banana powder, 30 parts of sweet potato powder, 40 parts of orange powder, 8 parts of konjac powder, and 35 parts of tomato powder.

The preparation method of the above special medical food is as follows:

S1. Preparation of potato pulp extract:

(1) Impurity removal: Take fresh potato residue, wash it thoroughly until the washing liquid is clear, mix the potato residue and water according to the mass ratio of 1:25, add 7 U/g of medium-temperature α-amylase based on the mass of potato residue, 60°C Stir and hydrolyze for 1 hour; after dehydration, use 2wt% NaHCO ₃ solution to soak the potato residue, submerge it, stir intermittently, and soak for 1 hour; wash with clean water.

(2) Grinding: After drying the impurity-free potato residue, use a high-speed universal grinder to coarsely grind the coarse powder, and then use an ultrafine grinder to ultrafinely grind the coarse powder to obtain ultrafine potato residue powder.

(3) Extraction: Add 4wt% citric acid solution to the potato residue ultrafine powder, and microwave it at 400W for 5 minutes; the mass ratio of the potato residue ultrafine powder to the citric acid solution is 1:35. After microwave treatment, centrifuge at 3000 rpm for 5 min to collect the supernatant.

(4) Alcohol precipitation: Concentrate the supernatant obtained in step (3) to 1/5 of the original volume, then add 4 times its volume of absolute ethanol to the concentrated solution, and leave it to be refrigerated at 3°C for 18 hours. Centrifuge at 3000 rpm for 5 min, wash the precipitate twice with ethanol, freeze-dry, and grind into coarse powder with a particle size of 60 to 90 mesh.

S2. Preparation of apple powder: Select high-quality apples with thin skin and thick flesh, fully mature, clean, peel and remove the core, cut into 7~8 mm thick round slices, put the cut apple slices in 3.5wt% salt The color is protected in the water solution to avoid oxidation and blackening, and then vacuum freeze-dried and crushed into coarse powder with a particle size of 60~90 mesh.

S3. Preparation of banana powder: Select a fully ripe banana, cut it in half, brush a layer of lemon juice on the cut surface, then peel it, brush a layer of lemon juice on the peeled area, vacuum freeze-dry it and crush it into a particle size of 60~90 mesh. of coarse powder.

S4. Preparation of sweet potato flour: Select high-quality sweet potatoes with no erosion, no spots, clean them, peel them, slice them, put them in the drying room, and bake them at 70~90°C until crispy. Always drain the moisture during the drying process. After drying, grind it into coarse powder with a particle size of 60~90 mesh.

S5. Preparation of orange powder: select fresh high-quality sweet oranges, clean them, peel them, slice them, vacuum freeze-dry them, and crush them into coarse powder with a particle size of 60 to 90 mesh.

S6. Preparation of tomato powder: Select high-quality tomatoes with high maturity, clean, peel, slice, vacuum freeze-dry, and crush into coarse powder with a particle size of 60~90 mesh.

S7. Mixing: Mix the potato extract coarse powder, fruit and vegetable coarse powder, purchased konjac powder, and resistant dextrin prepared above according to the formula proportion, and grind them into ultra-fine powder with a particle size of 1~10µm.

S8. Packaging: Pack the ultrafine powder of the mixture in step S7 with a packaging specification of 20~50g/bag.

Example 2

A special medical food for people with hypertension and constipation, consisting of the following components in parts by weight: 50 parts of potato residue extract, 10 parts of resistant dextrin, and 30 parts of fruit and vegetable powder.

Among them, the fruit and vegetable powder consists of the following components in parts by weight: 30 parts of apple powder, 50 parts of banana powder, 50 parts of sweet potato powder, 30 parts of orange powder, 10 parts of konjac powder, and 15 parts of tomato powder.

The preparation method of the above special medical food is the same as in Example 1.

Example 3

A special medical food for people with hypertension and constipation, consisting of the following components in parts by weight: 40 parts of potato residue extract, 15 parts of resistant dextrin, and 40 parts of fruit and vegetable powder.

Among them, the fruit and vegetable powder consists of the following components in parts by weight: 40 parts of apple powder, 40 parts of banana powder, 40 parts of sweet potato powder, 20 parts of orange powder, 5 parts of konjac powder, and 25 parts of tomato powder.

The preparation method of the above special medical food is the same as in Example 1.

Comparative example 1

Referring to Example 2, the difference from Example 2 is that the formula of the special medical food only includes 50 parts of potato residue extract and 10 parts of resistant dextrin.

Comparative example 2

Referring to Example 2, the difference from Example 2 is that the formula of the special medical food only includes 10 parts of resistant dextrin and 30 parts of fruit and vegetable powder.

Comparative example 3

Referring to Example 2, the difference from Example 2 is that the same amount of potato residue extract is replaced by sweet potato residue water extract. Wherein, the sweet potato residue is the waste produced after sweet potato produces starch.

Comparative example 4

Referring to Example 2, the difference from Example 2 is that the same amount of potato pulp extract is replaced by soybean pulp water extract. Among them, the soybean residue is the waste generated after the production of tofu.

Comparative example 5

Referring to Example 2, the difference from Example 2 is that the same amount of potato residue extract is replaced by lotus root residue water extract. Among them, the lotus root residue is the waste generated after the production of lotus root powder.

Note: The water extracts in Comparative Examples 3 to 5 are all water extracts obtained by using α-amylase to destarch the raw materials, removing impurities with NaHCO ₃ solution, and then using citric acid as a co-solvent.

Test 1

Effect of special medical food on blood pressure in spontaneously hypertensive rats.

1. Experimental materials

1. Test drug

The special medical food prepared in Examples 1 to 3 and Comparative Examples 1 to 5 is prepared into a solution of a certain concentration with distilled water.

2. Test animals

Animal sources: 90 male spontaneously hypertensive rats (SHR), weighing 180~220g; 9 male Wistar rats, weighing 180~220g, served as normal controls. All were provided by the Experimental Animal Center of Binzhou Medical College.

2. Experimental methods

1. Animal grouping and handling

The animals were adaptively raised for 5 days, during which their blood pressure was measured multiple times to adapt them to the pressure measurement environment. After 5 days, they were randomly divided into 10 groups according to body weight, with 9 animals in each group, which were respectively blank control group, model control group, Example 1 group, Example 2 group, Example 3 group, Comparative example group 1, and Comparative example group 2. , Comparative Example 3 Group, Comparative Example 4 Group, and Comparative Example 5 Group. The experimental group and the comparative group were given special medical food at a dose of 4g/kg. The prepared special medical food was administered to the rats according to the BW volume. The blank control group and the model control group were administered normal saline once a day. , for 30 consecutive days.

2. Determination of rat tail artery blood pressure

Place the rat in the holder, adjust the knobs on both sides of the holder and the tail cuff knob to make the rat in a relatively stable state. Place the high-sensitivity sensor under the tail cuff, close to the rat tail, and heat it to 37°C until the rat tail pulse The signal is very obvious and stable. Slowly pressurize the tail cuff until the pulse disappears and then slowly deflate it. Record each blood pressure value. The results are shown in Table 1.

3. Data statistics methods

The data are expressed as mean ± standard deviation (x ± s). The results were tested for significance using SPSS15.0 statistical software. p<0.05 means the difference is significant, and p<0.01 means the difference is extremely significant. Laboratory tests were carried out for each example and comparative example.

3. Experimental results

Note: Compared with the normal control group, # represents p<0.05, ## represents p<0.01; compared with the model control group, ★ represents p<0.05, ★★ represents p<0.01; compared with the Example 2 group, ▲ represents p<0.05, ▲▲ means p<0.01; compared with the same group before the experiment, $ means p<0.05, $$ means p<0.01.

It can be seen from Table 1 that before the experiment, the systolic blood pressure of the rats in the model control group, each example group, and each comparison group was higher than that of the normal control group, and the difference was extremely significant. After the experiment, the systolic blood pressure of the rats in the model control group, the example group, and the comparison group were all higher than the normal control group, and the differences with the control group were extremely significant; compared with the model control group, the systolic blood pressure of the rats in each example group was higher than that of the normal control group. The systolic blood pressure of the rats in each comparative group was lower than that of the model control group, and the difference was significant; compared with the Example 2 group, the systolic blood pressure of the rats in each comparative group was higher. In Example 2, Comparative Examples 1 and 2 are significantly different from Example 2, and Comparative Examples 3, 4, and 5 are significantly different from Example 2. Compared with the same group before the experiment, the difference in systolic blood pressure of the rats in the normal control group and the model control group was not significant. The differences in each example group were extremely significant. The differences in groups 1, 3, 4, and 5 of Comparative Examples were all significant. Comparative Example 2 Group differences were not significant.

Before the experiment, the diastolic blood pressure of rats in the model control group, each example group, and each comparison group was higher than that of the normal control group, and the differences were extremely significant. After the experiment, the diastolic blood pressure of the rats in the model control group, the example group, and the comparison group were all higher than the normal control group, and the differences with the control group were extremely significant; compared with the model control group, the diastolic blood pressure of the rats in each example group was higher than that of the normal control group. The diastolic blood pressure of rats in each comparative group was lower than that of the model control group, and the diastolic blood pressure of rats in each comparative group was significantly lower than that of the model control group. Among them, the difference between comparative group 1 and 3 and the model control group was extremely significant, and the diastolic blood pressure of rats in each comparative group was extremely significant. Compared with the model control group, the difference was significant; compared with the Example 2 group, the diastolic blood pressure of rats in each comparative group was higher than that of the Example 2 group, among which the Comparative Example Groups 2 and 4 were significantly different from the Example 2 group. The difference between the two groups is extremely significant, and the difference between the Comparative Example Group 1, Group 3 and Group 5 and the Example 2 Group is significant. Compared with the same group before the experiment, the difference in diastolic blood pressure of the rats in the normal control group and the model control group was not significant. The differences in each example group were extremely significant. The differences in groups 1, 3, 4, and 5 of Comparative Examples were all significant. Comparative Example 2 Group differences were not significant.

This shows that the special medical food in the present invention has significant blood pressure lowering effect, and the Example 2 group has the best blood pressure lowering effect.

Test 2

Effects of special medical foods on blood pressure in patients with hypertension and constipation.

Select 90 volunteers with hypertension and constipation, aged 25 to 65 years old, half and half men and women, and divided them into 3 groups, with 30 people in each group. They are Example 1 group, Example 2 group and Example 3 group respectively. Each embodiment group takes 20g each time, once a day. The blood pressure value was measured and recorded before the experiment. After taking the special medical food for 6 weeks, the blood pressure value was measured and recorded.

The effects after taking the special medical food are divided into the following 4 levels: Significant effect: After taking it for 6 weeks, the patient's blood pressure dropped by >10mmHg. Effective: After taking it for 6 weeks, the patient's blood pressure dropped by 5-10 mmHg. Ineffective: After taking it for 6 weeks, the patient’s blood pressure showed no significant change. Worsening: After taking it for 6 weeks, the patient's blood pressure showed no change and other adverse reactions occurred. The results are shown in Table 2.

Table 2 Effects of special medical foods on blood pressure in patients with hypertension and constipation

As can be seen from Table 2, in the Example 1 group, there were 20 cases with significant effects, 6 cases were effective, and 4 cases were ineffective; in the Example 2 group, there were 23 cases with significant effects, 5 cases were effective, and 2 cases were ineffective; in the Example 3 group, there were 19 cases with significant effects. 8 cases were effective and 3 cases were ineffective. There were no worsening cases in each group.

In Example 1, 66.67% of the results were significant, 20% were effective, 13.33% were ineffective, and the total effective rate was 86.67%. In Example 2, 76.67% of the results were significant, 16.67% were effective, 6.67% were ineffective, and the total effective rate was 93.33%. In Example 3, 63.33% of the results were significant, 26.67% were effective, 10% were ineffective, and the total effective rate was 90%.

It can be seen that the Example 2 group has the most significant effect in lowering blood pressure, followed by the Example 1 group and the Example 3 group, and there is no deterioration in any of the three groups.

The above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention shall be included in the protection of the present invention. within the range.

Claims (10)

1. A special medical food for people with hypertension and constipation, which is characterized in that it includes the following components in parts by weight: 30 to 50 parts of potato residue extract, 5 to 15 parts of resistant dextrin, and 30 to 50 parts of fruit and vegetable powder. 2. The special medical food according to claim 1, characterized in that the potato residue extract is a water extract of potato residue. 3. The special medical food according to claim 1 or 2, characterized in that the fruit and vegetable powder includes the following components in parts by weight: 30 to 50 parts of apple powder, 30 to 50 parts of banana powder, 30 to 50 parts of sweet potato powder, 20 to 40 parts of orange powder, 5 to 10 parts of konjac powder, and 15 to 35 parts of tomato powder. 4. The special medical food according to claim 3, characterized in that the glucomannan content of the konjac powder is 80~95%. 5. A method for preparing special medical food for people with hypertension and constipation according to any one of claims 1 to 4, characterized in that it includes a method for preparing potato residue extract, which includes the following steps: (1) Impurity removal: Use amylase to remove starch from potato residue; then soak it in alkali or alkaline salt solution to remove impurities; (2) Crushing: dry the impurity-removed potato residue and then crush it; (3) Extraction: Use citric acid as a co-solvent to extract the crushed potato residue with water; (4) Alcohol precipitation: Use ethanol to precipitate the leach solution. 6. The preparation method according to claim 5, characterized in that in step (1), the amylase is α-amylase. 7. The preparation method according to claim 5, characterized in that, in step (1), after removing starch, the potato residue is soaked with 1 to 5 wt% NaHCO ₃ solution for 0.5 to 2.5 hours. 8. The preparation method according to claim 5, characterized in that, in step (3): add 2~6wt% citric acid solution to the potato residue powder, and microwave it at 250~550W for 2~6 minutes; the potato residue powder and The mass ratio of citric acid solution is 1:(30~50). 9. The preparation method according to claim 5, characterized in that, in step (4): adding ethanol to the leach solution and then refrigeration at 0 to 4°C for 10 to 30 hours. 10. The preparation method according to claim 5, characterized in that the prepared dried potato residue extract powder, resistant dextrin powder, and fruit and vegetable powder are mixed according to the formula proportion and ground into a mixture with a particle size of 1 to 10 μm. powder.