CN117379356A - Nose protecting ointment and preparation method thereof - Google Patents
Nose protecting ointment and preparation method thereof Download PDFInfo
- Publication number
- CN117379356A CN117379356A CN202311684502.6A CN202311684502A CN117379356A CN 117379356 A CN117379356 A CN 117379356A CN 202311684502 A CN202311684502 A CN 202311684502A CN 117379356 A CN117379356 A CN 117379356A
- Authority
- CN
- China
- Prior art keywords
- parts
- oil
- extract
- phase
- nasal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 239000002674 ointment Substances 0.000 title abstract description 7
- 239000000284 extract Substances 0.000 claims abstract description 40
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims abstract description 34
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 28
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims abstract description 26
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 21
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 20
- 229940041616 menthol Drugs 0.000 claims abstract description 20
- 239000003921 oil Substances 0.000 claims abstract description 20
- 239000006071 cream Substances 0.000 claims abstract description 19
- 235000021314 Palmitic acid Nutrition 0.000 claims abstract description 17
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims abstract description 17
- 240000004307 Citrus medica Species 0.000 claims abstract description 16
- 241000218394 Magnolia liliiflora Species 0.000 claims abstract description 16
- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 claims abstract description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 15
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 14
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 14
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- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims abstract description 14
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims abstract description 14
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- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims abstract description 14
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- SMYKBXMWXCZOLU-UHFFFAOYSA-N tris-decyl benzene-1,2,4-tricarboxylate Chemical compound CCCCCCCCCCOC(=O)C1=CC=C(C(=O)OCCCCCCCCCC)C(C(=O)OCCCCCCCCCC)=C1 SMYKBXMWXCZOLU-UHFFFAOYSA-N 0.000 claims description 11
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- GLVVKKSPKXTQRB-UHFFFAOYSA-N ethenyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC=C GLVVKKSPKXTQRB-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
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- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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Abstract
The invention discloses a nose protecting ointment and a preparation method thereof. The nasal cream comprises hydrogenated palm kernel oil, tridecyl alcohol trimellitate, avocado fruit lipid, hydrogenated polyisobutene, beeswax, microcrystalline wax, paraffin, butylhydroxytoluene, C12-16 alcohol, hydrogenated lecithin, palmitic acid, trehalose esters, limonene, blue eucalyptus oil, menthol, borneolum Syntheticum, magnolia lilacina bud extract, radix astragali extract, lavender oil, citron fruit oil, tocopheryl acetate, phenoxyethanol, and herba Xanthii extract. Compared with the prior art, the nasal care paste prepared by the invention is added with the magnolia liliflora bud extract, so that capillaries of nasal mucosa can be contracted, and nasal bleeding can be reduced. The radix astragali extract, citron fruit oil, lavender oil and herba Xanthii extract are used as skin conditioner, and can improve and balance skin state, and provide moisturizing, nourishing and relieving effects. Menthol, which helps clear nasal obstruction and alleviate nasal discomfort.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a nose protecting paste and a preparation method thereof.
Background
The nose protecting ointment is one kind of product for protecting and moistening the skin inside nasal cavity. It usually takes the form of a paste or wax, containing a series of ingredients, with soothing, moisturizing and protecting the nasal cavity.
CN116549542a discloses an external ointment for treating acute and chronic allergic rhinitis, which is characterized in that: the external nasal paste comprises the following raw materials in percentage by mass: flos Magnoliae, herba Centipedae, herba Taraxaci, cortex Phellodendri, radix Scutellariae, rhizoma Acori Tatarinowii, radix Angelicae Dahuricae, fructus Xanthii, fructus forsythiae, herba asari, herba Pogostemonis, mentholum, vaseline, vegetable oil, cera flava, and fatty acid monoglyceride. The external rhinitis ointment disclosed by the invention can dispel wind and free the lung, is spicy and fragrant to dredge orifices, and has obvious curative effects on allergic rhinitis, chronic rhinitis, atrophic rhinitis, nasosinusitis, nasal polyp and acute and chronic paranasal sinusitis, and the allergen amount inhaled into the nose is reduced through adsorption and blocking effects.
CN116459289a discloses a traditional Chinese medicine ointment composition for external application of nasal cavity for treating allergic rhinitis, which comprises the following raw materials in parts by weight: 33-40 parts of centipeda minima, 12-12.5 parts of perilla leaf, 12-12.5 parts of cocklebur fruit, 8-9 parts of mint, 8-9 parts of radix angelicae, 8-9 parts of magnolia flower, 8-9 parts of liquorice and 4-6 parts of ephedra; the composition has antiinflammatory, antibacterial, antiallergic, and immunity regulating effects. The Chinese medicine is applied to nasal cavity to treat the disease, so that the medicine is directly contacted with nasal mucosa from the contact, the capillary vessel of the mucosa is expanded, the local blood circulation is quickened, and nerve endings are stimulated to control symptoms such as nasal itching, watery nasal discharge, sneeze and the like caused by mucosa edema and hypersensitivity.
Disclosure of Invention
The invention provides a preparation method of nose protection paste, which comprises the following steps:
s1, weighing raw materials according to a formula, and cleaning and sterilizing equipment;
s2, stirring the phase A raw material at 70-90 ℃ for 5-30min at a rotating speed of 20-100 rpm; then preserving heat at 70-90 ℃ for 20-40min;
s3, cooling to 40-70 ℃, adding the B phase raw material and the C phase raw material, and stirring at the speed of 20-100rpm for 5-30min at the temperature of 40-70 ℃;
s4, filling the materials into various types of packing materials, and cooling to obtain the finished product.
The A phase raw materials comprise hydrogenated palm kernel oil, tridecyl alcohol trimellitate, avocado fruit fat, hydrogenated polyisobutene, beeswax, microcrystalline wax, paraffin, butylhydroxytoluene, C12-16 alcohol, hydrogenated lecithin, palmitic acid, trehalose ester compounds and limonene; the phase B raw materials are as follows: eucalyptus globulus oil, menthol and borneol; the C phase raw material is: magnolia liliflora bud extract, radix astragali extract, lavender oil, citron fruit oil, tocopheryl acetate, phenoxyethanol and Xanthium sibiricum extract.
It is further preferable that the phase A raw materials comprise, by weight, 180-220 parts of hydrogenated palm kernel oil, 100-120 parts of tridecyl trimellitate, 90-100 parts of avocado fruit fat, 80-90 parts of hydrogenated polyisobutene, 70-90 parts of beeswax, 90-110 parts of microcrystalline wax, 20-30 parts of paraffin wax, 0.001-0.005 part of butylhydroxytoluene, 1-2 parts of C12-16 alcohol, 0.5-1.5 parts of hydrogenated lecithin, 0.5-1.5 parts of palmitic acid, 3-6 parts of trehalose ester compounds and 3-6 parts of limonene; the phase B raw materials are as follows: 70-90 parts of eucalyptus globulus oil, 10-30 parts of menthol and 10-30 parts of borneol; the C phase raw material is: 90-110 parts of magnolia liliflora bud extract, 10-30 parts of astragalus root extract, 10-30 parts of lavender oil, 10-30 parts of citron fruit oil, 2-5 parts of tocopheryl acetate, 2-5 parts of phenoxyethanol and 0.1-0.5 part of xanthium sibiricum extract.
It is further preferable that the phase a raw materials are, in parts by weight, 200 parts of hydrogenated palm kernel oil, 110 parts of tridecyl trimellitate, 100 parts of shea butter, 85 parts of hydrogenated polyisobutene, 80 parts of beeswax, 100 parts of microcrystalline wax, 26 parts of paraffin, 0.003 part of butylhydroxytoluene, 1.8 parts of C12-16 alcohol, 0.6 part of hydrogenated lecithin, 0.6 part of palmitic acid, 5 parts of trehalose ester compound, and 4.797 parts of limonene; the phase B raw materials are as follows: 80 parts of eucalyptus globulus oil, 20 parts of menthol and 20 parts of borneol; the C phase raw material is: 100 parts of magnolia liliflora flower bud extract, 20 parts of astragalus root extract, 20 parts of lavender oil, 20 parts of citron fruit oil, 3 parts of tocopheryl acetate, 3 parts of phenoxyethanol and 0.2 part of xanthium sibiricum extract.
Preferably, the preparation method of the trehalose ester compound comprises the following steps: uniformly mixing trehalose, tertiary butanol and dihydro-L-glucosone, adding lipase and fatty acid vinyl ester, and reacting at 50-70deg.C and 100-300rpm for 24-72 hr; cooling, filtering, and concentrating the filtrate under reduced pressure to 1/4 of the original volume; adsorbing and eluting with silica gel column, and drying to obtain trehalose esters.
Further preferably, the preparation method of the trehalose ester compound comprises the following steps: uniformly mixing 0.5-3g of trehalose, 10-20mL of tertiary butanol and 10-20mL of dihydro-L-glucosone, adding 0.5-3g of lipase and 1.5-6g of fatty acid vinyl ester, and reacting for 24-72h at 50-70 ℃ and 100-300 rpm; cooling, filtering, and concentrating the filtrate under reduced pressure to 1/4 of the original volume; adsorbing and eluting with silica gel column, and drying to obtain trehalose esters.
Preferably, the fatty acid vinyl ester is any one of palmitic acid vinyl ester, stearic acid vinyl ester, oleic acid vinyl ester, lauric acid vinyl ester or capric acid vinyl ester. Still more preferably, the fatty acid vinyl ester is vinyl palmitate.
Preferably, the eluent adopted in the elution is dichloromethane and methanol according to the volume ratio of 5-9:1, and mixing.
Hydrogenated palm kernel oil, avocado oil (avocado oil), hydrogenated polyisobutene, beeswax as emollients for providing skin moisturizing, moisturizing and softening effects. A protective film can be formed on the skin surface to prevent evaporation of water and provide moisturization.
Tridecyl trimellitate is a dispersing agent commonly used in cosmetics, has good lubricity, can be used for improving the lubricity and ductility of the cosmetics, and enables the products to be more easily applied and pushed away.
Microcrystalline wax, paraffin wax, and butylhydroxytoluene are used as thickening agents to increase the viscosity, and rheological properties of the paste.
C12-16 alcohol, hydrogenated lecithin and palmitic acid are used as emulsifying agents to improve the texture and touch of the paste, so that the paste is easier to smear and absorb. The softness, smoothness and viscosity of the paste can also be increased, and better use experience is provided.
Borneol, which is one of skin conditioning agents, can provide a pleasant feel to the skin.
The radix astragali extract, citron fruit oil, lavender oil and herba Xanthii extract are used as skin conditioner, and can improve and balance skin state, and provide moisturizing, nourishing and relieving effects.
Tocopheryl acetate, one of the antioxidants, helps to protect the skin from oxidative stress by protecting against free radical damage. Also has antiinflammatory and relieving effects, and can relieve skin discomfort and inflammatory reaction.
The phenoxyethanol, which is one of the preservatives, has broad-spectrum antibacterial and antifungal properties, can effectively inhibit the growth of microorganisms in cosmetics, and prolongs the shelf life of the products.
The magnolia liliflora flower bud extract can shrink capillaries of nasal mucosa, so that nasal hemorrhage can be reduced, and an antiallergic effect can be achieved, so that the auxiliary treatment of allergic rhinitis can be achieved.
The eucalyptus globulus oil contains abundant antibacterial and antiseptic components, and can effectively inhibit acne. It has histamine inhibiting effect and can be used as antiallergic agent. In addition, it has effects of promoting keratinocyte proliferation, scavenging free radicals, and preventing aging.
Menthol, derived from a natural herbal extract, can be used for nasal care. It can help clear nasal obstruction and alleviate nasal discomfort. The peppermint essential oil also has sedative and relaxing effects, and can help you relax mind and body and relieve stress and anxiety. Meanwhile, menthol has good effect of promoting skin penetration.
The limonene has good permeability, can help other active ingredients to better permeate into skin, and improves the absorption effect of the active ingredients of the paste.
The invention has the beneficial effects that:
1. compared with the prior art, the magnolia liliflora flower bud extract can shrink capillaries of nasal mucosa, so that nasal hemorrhage can be reduced, and an antiallergic effect can be achieved, so that the auxiliary treatment of allergic rhinitis can be achieved. The radix astragali extract, citron fruit oil, lavender oil and herba Xanthii extract are used as skin conditioner, and can improve and balance skin state, and provide moisturizing, nourishing and relieving effects. Menthol, which helps clear nasal obstruction and alleviate nasal discomfort. Meanwhile, menthol has good effect of promoting skin penetration.
2. Compared with the prior art, the invention can effectively improve the skin permeation effect of the nose-protecting cream by the synergistic use of the trehalose palmitate compound synthesized by the trehalose and the palmitic acid and the limonene.
Detailed Description
The invention is further illustrated with reference to specific embodiments.
The magnolia liliflora flower bud extract, the astragalus root extract and the xanthium sibiricum extract in the embodiment of the invention are all products obtained by a conventional water extraction method.
Example 1
A preparation method of the nose protection paste comprises the following steps:
the raw materials are divided into a phase A, a phase B and a phase C, and the total weight of the raw materials is 1000 g:
the A phase raw material is: 209.797g of hydrogenated palm kernel oil, 110g of tridecyl trimellitate, 100g of avocado fruit fat, 85g of hydrogenated polyisobutene, 80g of beeswax, 100g of microcrystalline wax, 26g of paraffin, 0.003g of butylhydroxytoluene, 1.8g of C12-16 alcohol, 0.6g of hydrogenated lecithin and 0.6g of palmitic acid;
the phase B raw materials are as follows: 80g of eucalyptus globulus oil, 20g of menthol and 20g of borneol;
the C phase raw material is: 100g of magnolia liliflora bud extract, 20g of astragalus root extract, 20g of lavender oil, 20g of citron fruit oil, 3g of tocopheryl acetate, 3g of phenoxyethanol and 0.2g of xanthium sibiricum extract;
s1, weighing raw materials according to a formula, and cleaning and sterilizing equipment;
s2, sequentially adding the phase A raw materials into a stirring pot, and stirring at the temperature of 85 ℃ for 10min at the rotating speed of 50 rpm; then preserving the temperature at 85 ℃ for 25min;
s3, cooling to 60 ℃, adding the B phase raw material and the C phase raw material, and stirring at the temperature of 60 ℃ for 10min at the rotating speed of 50 rpm;
s4, filling the materials into various types of packing materials, and cooling to obtain the finished product.
Example 2
A preparation method of the nose protection paste comprises the following steps:
the raw materials are divided into a phase A, a phase B and a phase C, and the total weight of the raw materials is 1000 g:
the A phase raw material is: 200g of hydrogenated palm kernel oil, 110g of tridecyl trimellitate, 100g of avocado fruit lipid, 85g of hydrogenated polyisobutene, 80g of beeswax, 100g of microcrystalline wax, 26g of paraffin, 0.003g of butylhydroxytoluene, 1.8g of C12-16 alcohol, 0.6g of hydrogenated lecithin, 0.6g of palmitic acid and 9.797g of trehalose ester compound;
the phase B raw materials are as follows: 80g of eucalyptus globulus oil, 20g of menthol and 20g of borneol;
the C phase raw material is: 100g of magnolia liliflora bud extract, 20g of astragalus root extract, 20g of lavender oil, 20g of citron fruit oil, 3g of tocopheryl acetate, 3g of phenoxyethanol and 0.2g of xanthium sibiricum extract;
s1, weighing raw materials according to a formula, and cleaning and sterilizing equipment;
s2, sequentially adding the phase A raw materials into a stirring pot, and stirring at the temperature of 85 ℃ for 10min at the rotating speed of 50 rpm; then preserving the temperature at 85 ℃ for 25min;
s3, cooling to 60 ℃, adding the B phase raw material and the C phase raw material, and stirring at the temperature of 60 ℃ for 10min at the rotating speed of 50 rpm;
s4, filling the materials into various types of packing materials, and cooling to obtain the finished product.
The preparation method of the trehalose ester compound comprises the following steps: 1g of trehalose, 15mL of tertiary butanol and 15mL of dihydro-L-glucosone are uniformly mixed, 1g of lipase and 3.3g of vinyl palmitate are added for reaction for 48 hours at 60 ℃ and 200 rpm; cooling, filtering, and concentrating the filtrate under reduced pressure to 1/4 of the original volume; adsorbing and eluting with silica gel column, and drying to obtain trehalose esters.
The eluent adopted by the elution is dichloromethane and methanol according to the volume ratio of 9:1, and mixing.
Example 3
A preparation method of the nose protection paste comprises the following steps:
the raw materials are divided into a phase A, a phase B and a phase C, and the total weight of the raw materials is 1000 g:
the A phase raw material is: 200g of hydrogenated palm kernel oil, 110g of tridecyl trimellitate, 100g of avocado fruit lipid, 85g of hydrogenated polyisobutene, 80g of beeswax, 100g of microcrystalline wax, 26g of paraffin, 0.003g of butylhydroxytoluene, 1.8g of C12-16 alcohol, 0.6g of hydrogenated lecithin, 0.6g of palmitic acid and 9.797g of trehalose ester compound;
the phase B raw materials are as follows: 80g of eucalyptus globulus oil, 20g of menthol and 20g of borneol;
the C phase raw material is: 100g of magnolia liliflora bud extract, 20g of astragalus root extract, 20g of lavender oil, 20g of citron fruit oil, 3g of tocopheryl acetate, 3g of phenoxyethanol and 0.2g of xanthium sibiricum extract;
s1, weighing raw materials according to a formula, and cleaning and sterilizing equipment;
s2, sequentially adding the phase A raw materials into a stirring pot, and stirring at the temperature of 85 ℃ for 10min at the rotating speed of 50 rpm; then preserving the temperature at 85 ℃ for 25min;
s3, cooling to 60 ℃, adding the B phase raw material and the C phase raw material, and stirring at the temperature of 60 ℃ for 10min at the rotating speed of 50 rpm;
s4, filling the materials into various types of packing materials, and cooling to obtain the finished product.
The preparation method of the trehalose ester compound comprises the following steps: 1g of trehalose, 15mL of tertiary butanol and 15mL of dihydro-L-glucosone are uniformly mixed, and then 1g of lipase and 3.3g of vinyl decanoate are added for reaction for 48 hours at 60 ℃ and 200 rpm; cooling, filtering, and concentrating the filtrate under reduced pressure to 1/4 of the original volume; adsorbing and eluting with silica gel column, and drying to obtain trehalose esters.
The eluent adopted by the elution is dichloromethane and methanol according to the volume ratio of 9:1, and mixing.
Example 4
A preparation method of the nose protection paste comprises the following steps:
the raw materials are divided into a phase A, a phase B and a phase C, and the total weight of the raw materials is 1000 g:
the A phase raw material is: 200g of hydrogenated palm kernel oil, 110g of tridecyl trimellitate, 100g of avocado fruit lipid, 85g of hydrogenated polyisobutene, 80g of beeswax, 100g of microcrystalline wax, 26g of paraffin, 0.003g of butylhydroxytoluene, 1.8g of C12-16 alcohol, 0.6g of hydrogenated lecithin, 0.6g of palmitic acid and 9.797g of trehalose;
the phase B raw materials are as follows: 80g of eucalyptus globulus oil, 20g of menthol and 20g of borneol;
the C phase raw material is: 100g of magnolia liliflora bud extract, 20g of astragalus root extract, 20g of lavender oil, 20g of citron fruit oil, 3g of tocopheryl acetate, 3g of phenoxyethanol and 0.2g of xanthium sibiricum extract;
s1, weighing raw materials according to a formula, and cleaning and sterilizing equipment;
s2, sequentially adding the phase A raw materials into a stirring pot, and stirring at the temperature of 85 ℃ for 10min at the rotating speed of 50 rpm; then preserving the temperature at 85 ℃ for 25min;
s3, cooling to 60 ℃, adding the B phase raw material and the C phase raw material, and stirring at the temperature of 60 ℃ for 10min at the rotating speed of 50 rpm;
s4, filling the materials into various types of packing materials, and cooling to obtain the finished product.
Example 5
A preparation method of the nose protection paste comprises the following steps:
the raw materials are divided into a phase A, a phase B and a phase C, and the total weight of the raw materials is 1000 g:
the A phase raw material is: 200g of hydrogenated palm kernel oil, 110g of tridecyl trimellitate, 100g of avocado fruit lipid, 85g of hydrogenated polyisobutene, 80g of beeswax, 100g of microcrystalline wax, 26g of paraffin, 0.003g of butylhydroxytoluene, 1.8g of C12-16 alcohol, 0.6g of hydrogenated lecithin, 0.6g of palmitic acid and 9.797g of limonene;
the phase B raw materials are as follows: 80g of eucalyptus globulus oil, 20g of menthol and 20g of borneol;
the C phase raw material is: 100g of magnolia liliflora bud extract, 20g of astragalus root extract, 20g of lavender oil, 20g of citron fruit oil, 3g of tocopheryl acetate, 3g of phenoxyethanol and 0.2g of xanthium sibiricum extract;
s1, weighing raw materials according to a formula, and cleaning and sterilizing equipment;
s2, sequentially adding the phase A raw materials into a stirring pot, and stirring at the temperature of 85 ℃ for 10min at the rotating speed of 50 rpm; then preserving the temperature at 85 ℃ for 25min;
s3, cooling to 60 ℃, adding the B phase raw material and the C phase raw material, and stirring at the temperature of 60 ℃ for 10min at the rotating speed of 50 rpm;
s4, filling the materials into various types of packing materials, and cooling to obtain the finished product.
Example 6
A preparation method of the nose protection paste comprises the following steps:
the raw materials are divided into a phase A, a phase B and a phase C, and the total weight of the raw materials is 1000 g:
the A phase raw material is: 200g of hydrogenated palm kernel oil, 110g of tridecyl trimellitate, 100g of avocado fruit lipid, 85g of hydrogenated polyisobutene, 80g of beeswax, 100g of microcrystalline wax, 26g of paraffin, 0.003g of butylhydroxytoluene, 1.8g of C12-16 alcohol, 0.6g of hydrogenated lecithin, 0.6g of palmitic acid, 5g of trehalose ester compound and 4.797g of limonene;
the phase B raw materials are as follows: 80g of eucalyptus globulus oil, 20g of menthol and 20g of borneol;
the C phase raw material is: 100g of magnolia liliflora bud extract, 20g of astragalus root extract, 20g of lavender oil, 20g of citron fruit oil, 3g of tocopheryl acetate, 3g of phenoxyethanol and 0.2g of xanthium sibiricum extract;
s1, weighing raw materials according to a formula, and cleaning and sterilizing equipment;
s2, sequentially adding the phase A raw materials into a stirring pot, and stirring at the temperature of 85 ℃ for 10min at the rotating speed of 50 rpm; then preserving the temperature at 85 ℃ for 25min;
s3, cooling to 60 ℃, adding the B phase raw material and the C phase raw material, and stirring at the temperature of 60 ℃ for 10min at the rotating speed of 50 rpm;
s4, filling the materials into various types of packing materials, and cooling to obtain the finished product.
The preparation method of the trehalose ester compound comprises the following steps: 1g of trehalose, 15mL of tertiary butanol and 15mL of dihydro-L-glucosone are uniformly mixed, 1g of lipase and 3.3g of vinyl palmitate are added for reaction for 48 hours at 60 ℃ and 200 rpm; cooling, filtering, and concentrating the filtrate under reduced pressure to 1/4 of the original volume; adsorbing and eluting with silica gel column, and drying to obtain trehalose esters.
The eluent adopted by the elution is dichloromethane and methanol according to the volume ratio of 9:1, and mixing.
Test example 1
By follow-up tests on the population (children 50, adults 50) using the nasal cream of example 6. The paste has obvious curative effect, especially faster and better effect for children.
Test example 2
Transdermal absorption test: cutting Corii Sus Domestica to size of about 2.5cm×2.5cm, fixing on vertical Franz diffusion cell equipped with magnetic stirrer, facing horny layer side toward supply cell, facing dermis side toward receiving cell (volume 18mL, inner diameter 2 cm), and applying nasal cream (application amount 0.1 g/cm) on horny layer side 2 ) The supply tank and the receiving tank are connected and fixed, the pH7.4 phosphate buffer preheated to 37 ℃ is added into the receiving tank, the constant temperature 37 ℃ water bath and magnetic stirring are started, timing is started, 2mL is sampled from the receiving tank after 2h, and the same amount of pH7.4 phosphate buffer at 37 ℃ is timely supplemented. The received solution was filtered through a 0.45 μm filter, and the content of menthol in each sample solution was calculated by measuring, and the cumulative passage of menthol was calculated from the measured content.
TABLE 1
| 2h cumulative transmittance | |
| Example 1 | 4.12% |
| Example 2 | 7.27% |
| Example 3 | 6.18% |
| Example 4 | 3.18% |
| Example 5 | 7.06% |
| Example 6 | 9.31% |
As can be seen from the above table, the transdermal absorption effect of the nasal cream of example 6 is significantly better than that of the nasal cream of example 2 or 5. The reasons for this may be: meanwhile, compared with the independently added trehalose ester compound or limonene, the added trehalose ester compound and limonene have better synergistic effect. Meanwhile, the nasal cream of example 5 had a better percutaneous absorption effect than that of example 2. The possible reasons for this are: compared with trehalose ester compounds synthesized by trehalose and palmitic acid, the trehalose ester compounds synthesized by trehalose and palmitic acid have stronger destructiveness on the integrity of cell monolayers, can better promote the redistribution of linker proteins, and realize better permeation promotion.
Test example 3
Stability test
The phenomenon of alcohol-oil separation of pastes is due to the presence of oil and alcohol components in some pastes, which may separate after a long period of time. Typically, the surface is a layer of apparent grease on the surface of the paste.
100g of the pastes of examples 1 to 6 were each placed in a transparent glass bottle and sealed, and stored at 48℃and the time for the paste to exhibit an alcohol-oil separation phenomenon was recorded.
TABLE 2
| Occurrence of oil-alcohol separation | |
| Example 1 | 42 days |
| Example 2 | 125 days |
| Example 3 | 96 days |
| Example 4 | 45 days |
| Example 5 | 41 days |
| Example 6 | 116 days |
From the above table, it can be seen that the addition of trehalose esters in the nasal cream in examples 2, 3 and 6 can effectively improve the oleyl alcohol separation effect of the nasal cream. The possible reasons for this are: the trehalose ester compound can form a colloid structure with other components in the nose protecting cream, increase the viscosity of the cream, and prevent the deposition and phase separation of the components. The trehalose ester compound may form a film on the liquid interface, reduce the surface tension of the liquid interface, reduce the mutual attraction between liquid drops, prevent the aggregation and sedimentation of oil drops, and increase the stability of paste.
The foregoing describes in detail preferred embodiments of the present invention. It should be understood that numerous modifications and variations can be made in accordance with the concepts of the invention by one of ordinary skill in the art without undue burden. Therefore, all technical solutions which can be obtained by logic analysis, reasoning or limited experiments based on the prior art by the person skilled in the art according to the inventive concept shall be within the scope of protection defined by the claims.
Claims (9)
1. The preparation method of the nose protection paste is characterized by comprising the following steps:
s1, weighing raw materials according to a formula, and cleaning and sterilizing equipment;
s2, stirring the phase A raw material at 70-90 ℃ for 5-30min at a rotating speed of 20-100 rpm; then preserving heat at 70-90 ℃ for 20-40min;
s3, cooling to 40-70 ℃, adding the B phase raw material and the C phase raw material, and stirring at the speed of 20-100rpm for 5-30min at the temperature of 40-70 ℃;
s4, filling the materials into various types of packaging materials, and cooling to obtain the finished product;
the A phase raw materials comprise hydrogenated palm kernel oil, tridecyl alcohol trimellitate, avocado fruit fat, hydrogenated polyisobutene, beeswax, microcrystalline wax, paraffin, butylhydroxytoluene, C12-16 alcohol, hydrogenated lecithin, palmitic acid, trehalose ester compounds and limonene; the phase B raw materials are as follows: eucalyptus globulus oil, menthol and borneol; the C phase raw material is: magnolia liliflora bud extract, radix astragali extract, lavender oil, citron fruit oil, tocopheryl acetate, phenoxyethanol and Xanthium sibiricum extract.
2. The method for preparing the nasal cream according to claim 1, wherein: the A phase raw materials comprise, by weight, 180-220 parts of hydrogenated palm kernel oil, 100-120 parts of tridecyl trimellitate, 90-100 parts of shea butter, 80-90 parts of hydrogenated polyisobutene, 70-90 parts of beeswax, 90-110 parts of microcrystalline wax, 20-30 parts of paraffin, 0.001-0.005 part of butylhydroxytoluene, 1-2 parts of C12-16 alcohol, 0.5-1.5 parts of hydrogenated lecithin, 0.5-1.5 parts of palmitic acid, 3-6 parts of trehalose ester compounds and 3-6 parts of limonene; the phase B raw materials are as follows: 70-90 parts of eucalyptus globulus oil, 10-30 parts of menthol and 10-30 parts of borneol; the C phase raw material is: 90-110 parts of magnolia liliflora bud extract, 10-30 parts of astragalus root extract, 10-30 parts of lavender oil, 10-30 parts of citron fruit oil, 2-5 parts of tocopheryl acetate, 2-5 parts of phenoxyethanol and 0.1-0.5 part of xanthium sibiricum extract.
3. The method for preparing the nasal cream according to claim 2, wherein: the A phase raw materials comprise, by weight, 200 parts of hydrogenated palm kernel oil, 110 parts of tridecyl trimellitate, 100 parts of avocado fruit lipid, 85 parts of hydrogenated polyisobutene, 80 parts of beeswax, 100 parts of microcrystalline wax, 26 parts of paraffin, 0.003 part of butylhydroxytoluene, 1.8 parts of C12-16 alcohol, 0.6 part of hydrogenated lecithin, 0.6 part of palmitic acid, 5 parts of trehalose ester compounds and 4.797 parts of limonene; the phase B raw materials are as follows: 80 parts of eucalyptus globulus oil, 20 parts of menthol and 20 parts of borneol; the C phase raw material is: 100 parts of magnolia liliflora flower bud extract, 20 parts of astragalus root extract, 20 parts of lavender oil, 20 parts of citron fruit oil, 3 parts of tocopheryl acetate, 3 parts of phenoxyethanol and 0.2 part of xanthium sibiricum extract.
4. A method for preparing the nasal cream as claimed in claim 1, 2 or 3, wherein: the preparation method of the trehalose ester compound comprises the following steps: uniformly mixing trehalose, tertiary butanol and dihydro-L-glucosone, adding lipase and fatty acid vinyl ester, and reacting at 50-70deg.C and 100-300rpm for 24-72 hr; cooling, filtering, and concentrating the filtrate under reduced pressure to 1/4 of the original volume; adsorbing and eluting with silica gel column, and drying to obtain trehalose esters.
5. The method for preparing the nasal cream according to claim 4, wherein: the preparation method of the trehalose ester compound comprises the following steps: uniformly mixing 0.5-3g of trehalose, 10-20mL of tertiary butanol and 10-20mL of dihydro-L-glucosone, adding 0.5-3g of lipase and 1.5-6g of fatty acid vinyl ester, and reacting for 24-72h at 50-70 ℃ and 100-300 rpm; cooling, filtering, and concentrating the filtrate under reduced pressure to 1/4 of the original volume; adsorbing and eluting with silica gel column, and drying to obtain trehalose esters.
6. The method for preparing the nasal cream according to claim 1, wherein: the fatty acid vinyl ester is any one of palmitic acid vinyl ester, stearic acid vinyl ester, oleic acid vinyl ester, lauric acid vinyl ester or capric acid vinyl ester.
7. The method for preparing the nasal cream according to claim 6, wherein: the fatty acid vinyl ester is palmitic acid vinyl ester.
8. The method for preparing the nasal cream according to claim 5, wherein: the eluent adopted by the elution is dichloromethane and methanol according to the volume ratio of 5-9:1, and mixing.
9. A nasal cream, characterized in that: prepared by the method of any one of claims 1-8.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202311684502.6A CN117379356B (en) | 2023-12-11 | 2023-12-11 | Nose protecting ointment and preparation method thereof |
| KR1020240039409A KR102662792B1 (en) | 2023-12-11 | 2024-03-21 | A nasal care ointment and its preparation method |
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| CN202311684502.6A CN117379356B (en) | 2023-12-11 | 2023-12-11 | Nose protecting ointment and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1761450A (en) * | 2003-02-13 | 2006-04-19 | 株式会社林原生物化学研究所 | External preparation for skin characterized by containing saccharide derivative of α,α-trehalose |
| CN104274633A (en) * | 2014-01-13 | 2015-01-14 | 北京德默高科医药技术有限公司 | Composition for cleaning and protecting nose |
| CN116536379A (en) * | 2023-06-19 | 2023-08-04 | 暨南大学 | A kind of preparation method and application of trehalose fatty acid monoester and diester |
-
2023
- 2023-12-11 CN CN202311684502.6A patent/CN117379356B/en active Active
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1761450A (en) * | 2003-02-13 | 2006-04-19 | 株式会社林原生物化学研究所 | External preparation for skin characterized by containing saccharide derivative of α,α-trehalose |
| CN104274633A (en) * | 2014-01-13 | 2015-01-14 | 北京德默高科医药技术有限公司 | Composition for cleaning and protecting nose |
| CN116536379A (en) * | 2023-06-19 | 2023-08-04 | 暨南大学 | A kind of preparation method and application of trehalose fatty acid monoester and diester |
Non-Patent Citations (1)
| Title |
|---|
| 乐比（广州）健康产业有限公司: "乐比护鼻膏", pages 324 - 326, Retrieved from the Internet <URL:https://hzpba.nmpa.gov.cn/gccx/chakan.html?prodId=1150802861416775680&gb=G> * |
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