CN117379096A - Superficial arterial flow velocity and fluctuation monitoring flexible array sensing device, signal acquisition method and system - Google Patents
Superficial arterial flow velocity and fluctuation monitoring flexible array sensing device, signal acquisition method and system Download PDFInfo
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Abstract
Description
技术领域Technical field
涉及生物医疗领域,具体涉及柔性阵列化传感器及其相关的采集分析系统。It involves the field of biomedicine, specifically flexible array sensors and related acquisition and analysis systems.
背景技术Background technique
随着生物医疗领域的发展,柔性阵列器件因其重量轻、易于轻便集成化且可贴合于多种复杂曲面等特性日渐成为研发重点。With the development of the biomedical field, flexible array devices have increasingly become the focus of research and development due to their light weight, easy integration, and ability to fit on a variety of complex curved surfaces.
目前常见的监测浅表层动脉流速的测量原理可分为有创式、无创式。其中有创式包含两种漂浮导管法(即普通型导管法以及Swan-Ganz导管法)通过测量右心室流入肺动脉血液的温升效应,经热敏电阻感知进而计算出心脏血流排出量,测量结果相对准确,但其缺点也相对明显,比如有创操作易于感染,不便于长期观察,且测试受到操作者操作误差影响,并且有创嵌入人体的部分也从一定程度上影响了血液循环。另外,无创操作的血液流速的测量包含体表置电极心电阻抗血流图和多普勒超声波技术方法。其中体表置电极心电阻抗测试中,受试者往往会被要求在不同位置佩戴电极,因此在人体位移时可能对测试结果产生一定的负面影响。Currently, common measurement principles for monitoring superficial arterial flow velocity can be divided into invasive and non-invasive. Among them, the invasive method includes two floating catheter methods (i.e., the ordinary catheter method and the Swan-Ganz catheter method). By measuring the temperature rise effect of blood flowing from the right ventricle into the pulmonary artery, the thermistor senses and then calculates the cardiac blood flow output, and measures The results are relatively accurate, but its shortcomings are also relatively obvious. For example, invasive operations are prone to infection and are not convenient for long-term observation, and the test is affected by operator errors, and the invasive parts embedded in the human body also affect blood circulation to a certain extent. In addition, non-invasive blood flow velocity measurement includes surface-mounted electrodes, electrocardiogram, impedance blood flow mapping and Doppler ultrasound technology. Among them, in the electrocardiographic impedance test with surface-mounted electrodes, subjects are often required to wear electrodes in different positions, so the displacement of the human body may have a certain negative impact on the test results.
目前常见的监测浅表层动脉波动的测量原理可分为压阻式、摩擦电式等。压阻式曲率应变传感器应用较为广泛,当该系统使用电阻率和应变传感器对浅表层动脉进行实施跟踪与采集,使用一个标准微型计算机用于接收电信号进行外部供电与计算,成本相对低廉,便于大批量生产。摩擦电式监测浅表层动脉波动的检测原理为正压电效应,当敏感材料沿一定方向受到动脉波动交变致作用而变形时,其内部会产生极化效应,在双侧表面上出现正负相反的电荷,当外力去掉后又重新恢复到零位状态。单独使用上述其中任意一种监测手段虽然灵敏度很高,但是生理信号与肢体运动信号解调困难,导致所需生理信号解耦不准确。Currently, the common measurement principles for monitoring superficial arterial fluctuations can be divided into piezoresistive and triboelectric methods. Piezoresistive curvature strain sensors are widely used. When the system uses resistivity and strain sensors to track and collect superficial arteries, it uses a standard microcomputer to receive electrical signals for external power supply and calculation. The cost is relatively low and convenient. Mass production. The detection principle of triboelectric monitoring of superficial arterial fluctuations is the positive piezoelectric effect. When the sensitive material is deformed by the alternating action of arterial fluctuations in a certain direction, a polarization effect will occur internally, and positive and negative phenomena will appear on both sides of the surface. The opposite charge returns to its zero position when the external force is removed. Although the sensitivity of using any of the above monitoring methods alone is high, it is difficult to demodulate physiological signals and limb movement signals, resulting in inaccurate decoupling of the required physiological signals.
在现实生活中,血液的流速往往会提供很多指导意义。例如当血液变得浓稠时,其流动速度就会变得缓慢,而脂肪就会沉淀在血管的内壁,从而引起管腔狭窄,供血不足。如果发生了严重的冠脉病变,将会引起严重的心脏缺血甚至是心肌梗塞。例如颅内血管变窄,成为脑梗死的重要诱因之一。在运动、静息的两种情况下,受试者的血管血流速率都不一样。对动脉血液流速进行测试,并理解它的变化规律,从而把握它的正常值范围与常见异常分析,这对我们进行人体器官的健康状态与动脉血液流速之间的关系的研究,并对多种心血管疾病的防治具有重要的指导作用。另外,在心脏停搏等紧急医疗抢救的过程中,脑组织的缺氧性损伤是较为常见的CPR预后脑死亡的重要原因之一。脑组织的动脉供血由4条大动脉完成,即颈内动脉系统和椎-基地动脉系统,其中大脑半球前3/5由颈内动脉系统供应。在心脏骤停后短时间内是否可以对大脑的血液灌注进行有效恢复,是患者的成功急救提供关键的评估与预测的黄金评判标准之一。因此在此种工况下,对于浅表层如颈动脉内流速实时监测对于CPR成功率进行实时评估,为自动心肺复苏仪提供实时的压力与节律变化提供指导。In real life, blood flow rate often provides a lot of guidance. For example, when blood becomes thicker, its flow speed will become slower, and fat will deposit on the inner wall of blood vessels, causing the lumen to become narrow and insufficient blood supply. If severe coronary artery disease occurs, it will cause severe cardiac ischemia or even myocardial infarction. For example, the narrowing of intracranial blood vessels has become one of the important causes of cerebral infarction. The subjects' vascular blood flow rates were different during exercise and rest. Testing the arterial blood flow velocity and understanding its changing rules, so as to grasp its normal value range and common abnormal analysis, will help us study the relationship between the health status of human organs and arterial blood flow velocity, and analyze various The prevention and treatment of cardiovascular disease plays an important guiding role. In addition, during emergency medical rescue such as cardiac arrest, hypoxic damage to brain tissue is one of the more common and important causes of brain death in the prognosis of CPR. The arterial blood supply to the brain tissue is completed by four large arteries, namely the internal carotid artery system and the vertebral-basal artery system, of which the first 3/5 of the cerebral hemisphere is supplied by the internal carotid artery system. Whether blood perfusion to the brain can be effectively restored within a short period of time after cardiac arrest is one of the gold standards that provides critical assessment and prediction for successful first aid for patients. Therefore, under such working conditions, real-time monitoring of the flow velocity in superficial layers such as the carotid artery can provide real-time assessment of the CPR success rate, and provide guidance for the automatic cardiopulmonary resuscitation instrument to provide real-time pressure and rhythm changes.
但是现有技术中,尚未提供一种柔性可穿戴阵列化传感器,可对浅表层如颈动脉内流速以及波动进行有效实时监测。However, the existing technology has not yet provided a flexible wearable arrayed sensor that can effectively monitor the flow velocity and fluctuations in superficial layers such as carotid arteries in real time.
发明内容Contents of the invention
针对现有技术中存在的,尚未提供一种可以对浅表层如颈动脉内流速进行有效实时监测的装置的技术问题,本发明提供的技术方案可以实现浅表层动脉流速及波动的监测,具体的技术方案为:In view of the technical problem existing in the prior art that a device that can effectively monitor the flow velocity in superficial layers such as carotid arteries in real time has not yet been provided. The technical solution provided by the present invention can realize the monitoring of flow velocity and fluctuations in superficial layers of arteries. Specifically, The technical solution is:
浅表层动脉流速及波动监测柔性阵列化传感装置,其特征在于,所述装置包括:A flexible array sensing device for monitoring superficial arterial flow velocity and fluctuations, characterized in that the device includes:
具有压阻探测能力的柔性背衬层,与所述柔性背衬层紧密贴合的柔性匹配层;A flexible backing layer with piezoresistive detection capability, and a flexible matching layer that closely fits the flexible backing layer;
设置在所述柔性匹配层和柔性背衬层之间的逆压电效应探测单元,所述逆压电效应探测单元为多普勒型超声探测阵列和B型超声探测阵列;An inverse piezoelectric effect detection unit provided between the flexible matching layer and the flexible backing layer, the inverse piezoelectric effect detection unit being a Doppler type ultrasonic detection array and a B-type ultrasonic detection array;
与所述柔性背衬层紧密贴合,且与所述柔性匹配层紧密相邻的摩擦电检测模块。A triboelectric detection module that is closely adhered to the flexible backing layer and closely adjacent to the flexible matching layer.
进一步,提供一个优选实施方式,所述多普勒型超声探测阵列设置在所述B型超声探测阵列和所述摩擦电检测模块之间。Furthermore, a preferred embodiment is provided, in which the Doppler-type ultrasonic detection array is disposed between the B-type ultrasonic detection array and the triboelectric detection module.
进一步,提供一个优选实施方式,所述多普勒型超声探测阵列中,存在与其他多普勒型超声探测单元倾角不同的多普勒型超声探测单元。Furthermore, a preferred embodiment is provided. In the Doppler ultrasonic detection array, there are Doppler ultrasonic detection units with different inclination angles from other Doppler ultrasonic detection units.
进一步,提供一个优选实施方式,所述摩擦电检测模块为摩擦电式传感单元。Furthermore, a preferred embodiment is provided, in which the triboelectric detection module is a triboelectric sensing unit.
进一步,提供一个优选实施方式,所述摩擦电式传感单元包括紧密贴合的敏感材料层和导电材料层。Furthermore, a preferred embodiment is provided, in which the triboelectric sensing unit includes a sensitive material layer and a conductive material layer that are in close contact with each other.
基于同一发明构思,本发明还提供了浅表层动脉流速及波动监测信号采集方法,所述方法包括:Based on the same inventive concept, the present invention also provides a method for collecting superficial arterial flow velocity and fluctuation monitoring signals. The method includes:
在统一的时钟信号下,采集待测信号的步骤;The steps of collecting the signal to be measured under a unified clock signal;
根据预设降噪方法,对所述待测信号的噪声和串扰进行处理的步骤;The step of processing the noise and crosstalk of the signal to be measured according to a preset noise reduction method;
提取所述待测信号中预设信号的步骤。The step of extracting a preset signal from the signal to be measured.
进一步,提供一个优选实施方式,所述待测信号包括B模式下动脉直径波动情况和多普勒模式下血流流速信息。Furthermore, a preferred embodiment is provided, in which the signal to be measured includes artery diameter fluctuations in B mode and blood flow velocity information in Doppler mode.
基于同一发明构思,本发明还提供了浅表层动脉流速及波动监测信号采集系统,所述系统包括:Based on the same inventive concept, the present invention also provides a superficial arterial flow velocity and fluctuation monitoring signal acquisition system. The system includes:
在统一的时钟信号下,采集待测信号的模块;A module that collects the signal to be tested under a unified clock signal;
根据预设降噪方法,对所述待测信号的噪声和串扰进行处理的模块;A module that processes the noise and crosstalk of the signal to be measured according to the preset noise reduction method;
提取所述待测信号中预设信号的模块。A module for extracting the preset signal from the signal to be measured.
基于同一发明构思,本发明还提供了计算机储存介质,用于储存计算机程序,当所述计算机程序被计算机读取时,所述计算机执行所述的方法。Based on the same inventive concept, the present invention also provides a computer storage medium for storing a computer program. When the computer program is read by a computer, the computer executes the method.
基于同一发明构思,本发明还提供了计算机,包括处理器和储存介质,当所述处理器读取所述储存介质中储存的计算机程序时,所述计算机执行所述的方法。Based on the same inventive concept, the present invention also provides a computer, including a processor and a storage medium. When the processor reads the computer program stored in the storage medium, the computer executes the method.
与现有技术相比,本发明提供的技术方案的有益之处在于:Compared with the existing technology, the technical solution provided by the present invention has the following benefits:
高度集成的系统:该系统包含了多个关键子系统,包括供电、采集、传输、预处理和信号处理,这些子系统紧密集成在一起,确保了高效的数据流和信号处理。Highly integrated system: The system contains multiple key subsystems, including power supply, acquisition, transmission, preprocessing and signal processing. These subsystems are tightly integrated to ensure efficient data flow and signal processing.
稳定的供电系统:主供电系统包括AC/DC市电转换和稳压系统,确保了系统的稳定供电,同时提供标准参考电压值,有助于提高采集的精确性和可靠性。Stable power supply system: The main power supply system includes AC/DC mains conversion and voltage stabilization systems, which ensures a stable power supply for the system and provides a standard reference voltage value, which helps improve the accuracy and reliability of collection.
信号处理和增强:系统在前端进行信号的必要放大、数模转换和滤波处理,这有助于提高信号质量,减少噪声干扰。Signal processing and enhancement: The system performs necessary signal amplification, digital-to-analog conversion and filtering processing at the front end, which helps to improve signal quality and reduce noise interference.
分布式高速采集:核心控制单元在统一时钟下进行分布式高速采集,确保了对多路采集的数据进行准确的同步采集,这对于时序相关的信号分析非常重要。Distributed high-speed acquisition: The core control unit performs distributed high-speed acquisition under a unified clock, ensuring accurate and synchronous acquisition of data collected from multiple channels, which is very important for timing-related signal analysis.
自适应降噪:中端的预处理单元具备硬件化的自适应降噪系统,能够处理噪声和串扰,尤其可以清晰的过滤掉肢体运动信号(大干扰信号),可提供较为清晰的生理信号结果,为后续的信号识别提供了更好的基础支持。Adaptive noise reduction: The mid-range pre-processing unit has a hardware-based adaptive noise reduction system, which can handle noise and crosstalk. In particular, it can clearly filter out body movement signals (large interference signals) and provide clearer physiological signal results. Provides better basic support for subsequent signal recognition.
多模式信号分析:系统能够处理不同模式下的信号,包括B模式下的动脉直径波动和多普勒模式下的血流流速信息。这种多模式分析有助于综合评估生理信号。Multi-mode signal analysis: The system can process signals in different modes, including artery diameter fluctuations in B mode and blood flow velocity information in Doppler mode. This multimodal analysis facilitates comprehensive assessment of physiological signals.
个性化的信号处理:系统能够根据不同人群类别的血液粘稠程度和血管壁的材料学特性参数进行特定化差异化分析,这意味着此系统尽可能得到最为接近的生理信号检测值。Personalized signal processing: The system can perform specific and differentiated analysis based on the blood viscosity of different groups of people and the material properties of the blood vessel wall, which means that the system can obtain the closest physiological signal detection value as possible.
准确的生理信号结果:通过多压电陶瓷倾斜角度阵列化多普勒流速超声计算等方法,系统能够提供较为精确的生理信号结果,这对于后续医疗诊断和分析研究非常有应用价值。Accurate physiological signal results: Through methods such as multi-piezoelectric ceramic tilt angle array Doppler flow velocity ultrasound calculation and other methods, the system can provide relatively accurate physiological signal results, which is very valuable for subsequent medical diagnosis and analysis research.
总的来说,本发明提供的技术方案的优点在于它的高度集成性、稳定性、信号处理能力以及多模式信号分析能力,这些特性使其在医学诊断、生物医学研究等领域具有广泛的应用前景。同时,个性化信号处理也使其更适用于不同个体和应用场景。In general, the advantages of the technical solution provided by the present invention lie in its high degree of integration, stability, signal processing capabilities and multi-mode signal analysis capabilities. These characteristics make it widely used in medical diagnosis, biomedical research and other fields. prospect. At the same time, personalized signal processing also makes it more suitable for different individuals and application scenarios.
适合应用于柔性阵列化传感器对于浅表层如颈动脉内流速实时监测的工作中。It is suitable for use in flexible array sensors for real-time monitoring of flow velocity in superficial layers such as carotid arteries.
附图说明Description of the drawings
图1为实施方式一提供的浅表层动脉流速及波动监测柔性阵列化传感装置的列基本组成与工作原理示意图;Figure 1 is a schematic diagram of the basic composition and working principle of a flexible arrayed sensing device for monitoring superficial arterial flow velocity and fluctuations provided in the first embodiment;
图2为实施方式五提到的摩擦电式传感单元的示意图;Figure 2 is a schematic diagram of the triboelectric sensing unit mentioned in the fifth embodiment;
图3为实施方式七提到的浅表层动脉流速及波动监测信号采集系统的系统示意图;Figure 3 is a system schematic diagram of the superficial arterial flow velocity and fluctuation monitoring signal acquisition system mentioned in the seventh embodiment;
图4为实施方式七提到的浅表层动脉流速及波动监测信号采集系统的技术路线示意图;Figure 4 is a schematic diagram of the technical route of the superficial arterial flow velocity and fluctuation monitoring signal acquisition system mentioned in the seventh embodiment;
图5为实施方式七提到的流速波动图结果示意图;Figure 5 is a schematic diagram of the results of the flow velocity fluctuation chart mentioned in the seventh embodiment;
图6为实施方式七提到的浅表层动脉流速及波动监测信号采集系统对按压实时评估与反馈的原理示意图。Figure 6 is a schematic diagram of the principle of real-time evaluation and feedback of compression by the superficial arterial flow velocity and fluctuation monitoring signal acquisition system mentioned in the seventh embodiment.
具体实施方式Detailed ways
为使本发明提供的技术方案的优点和有益之处体现得更清楚,现结合附图对本发明提供的技术方案进行进一步详细地描述,具体的:In order to make the advantages and benefits of the technical solutions provided by the present invention more clear, the technical solutions provided by the present invention are now described in further detail with reference to the accompanying drawings, specifically:
实施方式一、结合图1说明本实施方式,本实施方式提供了浅表层动脉流速及波动监测柔性阵列化传感装置,所述装置包括:Embodiment 1. This embodiment will be described with reference to Figure 1. This embodiment provides a flexible array sensing device for monitoring superficial artery flow velocity and fluctuations. The device includes:
具有压阻探测能力的柔性背衬层,与所述柔性背衬层紧密贴合的柔性匹配层;A flexible backing layer with piezoresistive detection capability, and a flexible matching layer that closely fits the flexible backing layer;
设置在所述柔性匹配层和柔性背衬层之间的逆压电效应探测单元,所述逆压电效应探测单元为多普勒型超声探测阵列和B型超声探测阵列;An inverse piezoelectric effect detection unit provided between the flexible matching layer and the flexible backing layer, the inverse piezoelectric effect detection unit being a Doppler type ultrasonic detection array and a B-type ultrasonic detection array;
与所述柔性背衬层紧密贴合,且与所述柔性匹配层紧密相邻的摩擦电检测模块。A triboelectric detection module that is closely adhered to the flexible backing layer and closely adjacent to the flexible matching layer.
柔性背衬层在摩擦电探测单元也被称之为柔性封装材料,既可以增加柔性超声器件探测部分的带宽,同时可以检测传感器被弯曲的角度,可增加声场的控制性并且有助于动脉波动的检测;The flexible backing layer in the triboelectric detection unit is also called a flexible packaging material. It can not only increase the bandwidth of the detection part of the flexible ultrasonic device, but also detect the angle at which the sensor is bent, which can increase the controllability of the sound field and contribute to arterial fluctuations. detection;
具体的,specific,
本实施方式描述了一种用于监测浅表层动脉流速及波动的柔性阵列化传感器,其结构示意图如图1所示。其中包含两种常见的逆压电效应测量模式,它们分别是B型超声以及多普勒超声(D型超声)两种方式。另外此阵列化传感器还包含正压电效应的摩擦电(TENG)检测部分以及具有压阻探测能力的柔性背衬层。This embodiment describes a flexible arrayed sensor for monitoring superficial arterial flow velocity and fluctuations, and its structural schematic diagram is shown in Figure 1. It includes two common inverse piezoelectric effect measurement modes, which are B-mode ultrasound and Doppler ultrasound (D-mode ultrasound). In addition, this arrayed sensor also includes a triboelectric (TENG) detection part with positive piezoelectric effect and a flexible backing layer with piezoresistive detection capability.
B型超声作为超声设备最常见的工作模式,在本实施方式中也被采用。工作在此模式下的阵列器件位于整个柔性传感系统的一侧,它可以观测直径波动。因其面阵化的设计,具有相控成像的能力。且当覆盖于人体皮肤上时,不易受到传感器轻微位移的影响,因为在采集系统中可以自动对焦于感兴趣的动脉区域。B-mode ultrasound, as the most common working mode of ultrasound equipment, is also used in this embodiment. The array device working in this mode is located on one side of the entire flexible sensing system, and it can observe diameter fluctuations. Because of its area array design, it has the capability of phased imaging. And when covered on human skin, it is not easily affected by slight displacement of the sensor because the acquisition system can automatically focus on the artery area of interest.
多普勒型超声(D型超声)使用多普勒技术检测血流速度时,其检出值受到声波波束、传播角度、以及血管倾斜度等因素的影响,可能造成结果不准确。在此专利中展示的多普勒超声阵列器件采用一些列不同的入射倾角(包括但不限于图中所示的两组倾角),并且使用同发同收脉冲多普勒的工作模式,对血液流速进行稳定准确的成像。同理,也因传感器阵元丰富且密集排布的设计,较大程度地规避了聚焦区域受限的问题。When Doppler ultrasound (D-mode ultrasound) uses Doppler technology to detect blood flow velocity, the detection value is affected by factors such as the sound wave beam, propagation angle, and blood vessel inclination, which may cause inaccurate results. The Doppler ultrasound array device shown in this patent adopts a series of different incident tilt angles (including but not limited to the two sets of tilt angles shown in the figure), and uses the simultaneous emission and simultaneous reception pulse Doppler working mode to detect blood Flow rate for stable and accurate imaging. In the same way, due to the rich and densely arranged design of sensor array elements, the problem of limited focus area is largely avoided.
实施方式二、本实施方式是对实施方式一提供的浅表层动脉流速及波动监测柔性阵列化传感装置的进一步限定,所述多普勒型超声探测阵列设置在所述B型超声探测阵列和所述摩擦电检测模块之间。Embodiment 2. This embodiment is a further limitation of the flexible arrayed sensing device for monitoring superficial arterial flow velocity and fluctuations provided in Embodiment 1. The Doppler-type ultrasonic detection array is disposed between the B-type ultrasonic detection array and between the triboelectric detection modules.
实施方式三、本实施方式是对实施方式一提供的浅表层动脉流速及波动监测柔性阵列化传感装置的进一步限定,所述多普勒型超声探测阵列中,存在与其他多普勒型超声探测单元倾角不同的多普勒型超声探测单元。Embodiment 3. This embodiment is a further limitation of the flexible arrayed sensing device for monitoring superficial arterial flow velocity and fluctuation provided in Embodiment 1. In the Doppler-type ultrasonic detection array, there are differences with other Doppler-type ultrasonic detection arrays. Doppler ultrasonic detection units with different inclination angles.
实施方式四、本实施方式是对实施方式一提供的浅表层动脉流速及波动监测柔性阵列化传感装置的进一步限定,所述摩擦电检测模块为摩擦电式传感单元。Embodiment 4. This embodiment is a further limitation of the flexible arrayed sensing device for monitoring superficial arterial flow velocity and fluctuation provided in Embodiment 1. The triboelectric detection module is a triboelectric sensing unit.
实施方式五、结合图2说明本实施方式,本实施方式是对实施方式一提供的浅表层动脉流速及波动监测柔性阵列化传感装置的进一步限定,所述摩擦电式传感单元包括紧密贴合的敏感材料层和导电材料层。Embodiment 5: This embodiment will be described with reference to Figure 2. This embodiment is a further limitation of the flexible arrayed sensing device for monitoring superficial arterial flow velocity and fluctuations provided in Embodiment 1. The triboelectric sensing unit includes a close-fitting Combined sensitive material layer and conductive material layer.
具体的,specific,
作为正压电效应测量振动的一种重要手段,摩擦电式传感单元被同样集成与本实施方式描述的阵列化系统之中。其具体组成单元如图2所示,图中蓝色部分为敏感材料PVDF或者其他具有良好压电性能的有机高分子多聚物,具有在受到振动的情况下产生电荷的功用。其产生的电荷通过图中黄橙色所示的导电材料导出,并实时检测与分析。同时上方覆盖一层柔性的压阻敏感材料封装层(如图中透明色框线)。此部分的测量可以相对有效的反应出动脉波动致传感器振动的变化规律。As an important means of measuring vibration by the positive piezoelectric effect, the triboelectric sensing unit is also integrated into the array system described in this embodiment. Its specific components are shown in Figure 2. The blue part in the figure is the sensitive material PVDF or other organic polymers with good piezoelectric properties, which have the function of generating charges when subjected to vibration. The charge generated is exported through the conductive material shown in yellow and orange in the picture, and is detected and analyzed in real time. At the same time, the upper part is covered with a flexible piezoresistive sensitive material encapsulation layer (transparent color frame in the picture). The measurement of this part can relatively effectively reflect the changing pattern of sensor vibration caused by arterial fluctuations.
另外,图1中所示的具有压阻探测能力的背衬层(或称为封装层),可以感知此传感阵列本身被弯曲的角度,以及受到的拉伸变化。此压阻式传感单元也可以用于探测器件本身附着与人体表皮上曲率的变化,有助于对于超声传感部分声场的控制。In addition, the backing layer (or encapsulation layer) with piezoresistive detection capability shown in Figure 1 can sense the angle at which the sensing array itself is bent and the tensile changes it undergoes. This piezoresistive sensing unit can also be used to detect changes in the curvature of the device itself attached to the human body's skin, helping to control the sound field in the ultrasonic sensing part.
实施方式六、本实施方式提供了浅表层动脉流速及波动监测信号采集方法,所述方法包括:Embodiment 6. This embodiment provides a method for collecting superficial arterial flow velocity and fluctuation monitoring signals. The method includes:
在统一的时钟信号下,采集待测信号的步骤;The steps of collecting the signal to be measured under a unified clock signal;
根据预设降噪方法,对所述待测信号的噪声和串扰进行处理的步骤;The step of processing the noise and crosstalk of the signal to be measured according to a preset noise reduction method;
提取所述待测信号中预设信号的步骤。The step of extracting a preset signal from the signal to be measured.
具体的,specific,
步骤一:在统一的时钟信号下,采集待测信号;Step 1: Collect the signal to be tested under a unified clock signal;
步骤二:根据自适应降噪方法(包括但不限于自适应小波变换),对所述待测信号噪声、信道串扰以及传感器位移干扰进行处理;Step 2: Process the signal noise, channel crosstalk and sensor displacement interference of the signal to be measured according to the adaptive noise reduction method (including but not limited to adaptive wavelet transform);
步骤三:根据不同人群类别的血液粘稠程度和血管壁的材料学特性参数在B模式超声下监测浅表层动脉波动信息时,使用类别化差异化分析;Step 3: Use categorical differential analysis when monitoring superficial artery fluctuation information under B-mode ultrasound based on the blood viscosity of different groups of people and the material properties of the blood vessel wall;
其中,动脉致皮肤起伏波动的监测使用下列装置:摩擦电探测部分、柔性压阻式背衬层探测部分。动脉直径波动监测中使用:B模式超声传感部分。动脉流速监测中使用:多普勒模式超声传感部分。Among them, the following devices are used to monitor the skin undulations caused by arteries: triboelectric detection part and flexible piezoresistive backing layer detection part. Used in arterial diameter fluctuation monitoring: B-mode ultrasonic sensing part. Used in arterial flow velocity monitoring: Doppler mode ultrasound sensing part.
步骤四:提取所述待测信号中预设信号并且对动脉波动与流速在三组数据来源下同一化分析。Step 4: Extract the preset signal from the signal to be measured and analyze the arterial fluctuation and flow velocity uniformly under the three sets of data sources.
实施方式七、本实施方式是对实施方式六提供的浅表层动脉流速及波动监测信号采集方法的进一步限定,所述待测信号包括B模式下动脉直径波动情况和多普勒模式下血流流速信息,并且利用血管硬度以及血液黏稠度在不同类别人群中的分布值,对浅表层动脉内血流的流速以及动脉波动情况进行同一化分析,可以通过两者的互相校验对动脉的流速以及波动进行表征。Embodiment 7. This embodiment is a further limitation of the superficial artery flow velocity and fluctuation monitoring signal collection method provided in Embodiment 6. The signal to be measured includes the fluctuation of artery diameter in B mode and the blood flow velocity in Doppler mode. information, and use the distribution values of blood vessel hardness and blood viscosity in different categories of people to conduct a unified analysis of the flow rate of blood flow in superficial arteries and arterial fluctuations. The flow rate of arteries and arterial fluctuations can be verified through mutual verification of the two. Fluctuations are represented.
实施方式八、结合图3-6说明本实施方式,本实施方式提供了浅表层动脉流速及波动监测信号采集系统,所述系统包括:Embodiment 8: This embodiment will be described with reference to Figures 3-6. This embodiment provides a superficial artery flow velocity and fluctuation monitoring signal acquisition system. The system includes:
在统一的时钟信号下,采集待测信号的模块;A module that collects the signal to be tested under a unified clock signal;
根据预设降噪方法,对所述待测信号的噪声和串扰进行处理的模块;A module that processes the noise and crosstalk of the signal to be measured according to the preset noise reduction method;
提取所述待测信号中预设信号的模块。A module for extracting the preset signal from the signal to be measured.
具体的,specific,
本实施方式提供的系统包括:The system provided by this implementation includes:
AC/DC市电转换系统以及稳压系统的模块、前端的核心控制单元、后端的信号处理系统、交互界面与警告系统和外设控制与储存单元。Modules of AC/DC mains conversion system and voltage stabilization system, front-end core control unit, back-end signal processing system, interactive interface and warning system, and peripheral control and storage unit.
本实施方式描述的信号采集与分析系统如图3所示,其中包含以下几个关键子系统:主供电系统:由主要有AC/DC市电转换系统以及稳压系统组成,稳压后电源作为系统供电及标准参考电压值输入给阵列化传感器采集系统。同时辅助以一些必要的信号对多路采集的信号进行必要的放大、数模转换以及滤波处理。前端的核心控制单元,主要的共用是:在统一的时钟下,对采集及传输系统进行分布式高速采集。中端的预处理单元,作为硬件化的自适应降噪系统,对噪声与串扰进行处理,为下一步的信号识别提供基础支持。后端的信号处理系统,主要区分B模式下动脉直径波动情况以及多普勒模式下血流流速信息,对这两种信号进行特征化计算,提出可供读取的信息。根据不同人群的血液粘稠程度与血管壁的材学特性参数,可初步的从直径波动情况得到相关流速信息以及流速波动节律,并且辅助以多角度阵列化多普勒超声的计算而得出的信息数据,从而获得较为准确的生理信号结果。The signal acquisition and analysis system described in this implementation mode is shown in Figure 3, which includes the following key subsystems: Main power supply system: It mainly consists of an AC/DC mains conversion system and a voltage stabilizing system. The stabilized power supply serves as The system power supply and standard reference voltage value are input to the arrayed sensor acquisition system. At the same time, it assists in using some necessary signals to perform necessary amplification, digital-to-analog conversion and filtering processing of the multi-channel collected signals. The front-end core control unit mainly shares the following functions: distributed high-speed acquisition of the acquisition and transmission system under a unified clock. The mid-end pre-processing unit, as a hardware-based adaptive noise reduction system, processes noise and crosstalk to provide basic support for the next step of signal recognition. The back-end signal processing system mainly distinguishes between artery diameter fluctuations in B mode and blood flow velocity information in Doppler mode, performs characteristic calculations on these two signals, and proposes information that can be read. According to the blood viscosity of different groups of people and the material properties of the blood vessel wall, the relevant flow velocity information and flow velocity fluctuation rhythm can be initially obtained from the diameter fluctuations, and assisted by the calculation of multi-angle arrayed Doppler ultrasound. information data to obtain more accurate physiological signal results.
本实施方式所描述的两种血管直径变化信息与血液流速信息的互相关性用于对最后输出结果的。同时交互界面控制系统的集成后,可以对这些数据进行基础操作,例如日期编码以及新建或删除。警告部分:当柔性阵列化传感器受到变化且异于标准值时,传感器输出的电压信号被收集到放大模块中。可通过编写程序设定,当超过设定值时,扬声器开始报警。同时辅以必要的外设控制设备以及储存单元,对生理信号进行基础分析控制及储存,以便后续在医生的帮助下进行细致化分析。The cross-correlation between the two types of blood vessel diameter change information and blood flow velocity information described in this embodiment is used for the final output result. At the same time, after the integration of the interactive interface control system, basic operations can be performed on these data, such as date encoding and creating or deleting. Warning part: When the flexible arrayed sensor is changed and different from the standard value, the voltage signal output by the sensor is collected into the amplification module. It can be set by writing a program. When the set value is exceeded, the speaker will start to alarm. At the same time, it is supplemented by necessary peripheral control equipment and storage units to perform basic analysis, control and storage of physiological signals for subsequent detailed analysis with the help of doctors.
图4为传感器的采集分析系统技术路线图。Figure 4 is the technology roadmap of the sensor acquisition and analysis system.
本实施方式还提供了两个具体的实施例:This implementation also provides two specific examples:
本实施方式使用多种采集模式组成的柔性传感系统对浅表层动脉流速及波动进行采集与分析。使用B/D型超声进行同目标生理参数校准,高效稳定的得出流速及其波动规律。This embodiment uses a flexible sensing system composed of multiple acquisition modes to collect and analyze superficial artery flow velocity and fluctuations. Use B/D type ultrasound to calibrate the physiological parameters of the same target, and obtain the flow rate and its fluctuation pattern efficiently and stably.
实施例一:用主周脉搏波区分度、与心血管疾病建立联系。脉搏波速(PWV)是反映血管弹性模量(或硬化程度)的重要参量,是反映动脉粥样硬化发生发展的重要指标。临床上比较常见的PWV可由由肱-踝脉波(BA-PWV)、颈-股脉波(CF-PWV)两个部分组成,两个部分分别用两点时间差法测定;本实施方式中描述的柔性可穿戴阵列化易于贴合到人体的对应区域,并对传递时间关系实时监测,以此来反映心脑血管弹性指征的改变。图5为此种柔性传感系统附着于人体桡动脉的监测结果。可在图中清晰地观察导重搏波波峰,其生理学意义上,对应心动周期的舒张期波峰。重搏波的高度在生理上意味着动脉的弹性以及主动脉瓣膜关闭速度。若重搏波波峰越高,意味着动脉的弹性越好,主动脉瓣膜的关闭功能正常;若重搏波的高度低,意味着动脉的弹性越差,主动脉瓣膜的关闭功能不正常,有动脉硬化的趋势。Embodiment 1: Using peripheral pulse waves to differentiate and establish connections with cardiovascular diseases. Pulse wave velocity (PWV) is an important parameter reflecting the elastic modulus (or degree of hardening) of blood vessels and an important indicator reflecting the occurrence and development of atherosclerosis. The clinically common PWV can be composed of two parts: brachial-ankle pulse wave (BA-PWV) and carotid-femoral pulse wave (CF-PWV). The two parts are measured using the two-point time difference method; described in this embodiment. The flexible wearable array is easy to fit to the corresponding areas of the human body, and the delivery time relationship is monitored in real time to reflect changes in cardiovascular and cerebrovascular elasticity indicators. Figure 5 shows the monitoring results of this flexible sensing system attached to the human radial artery. The peak of the pulse wave can be clearly observed in the figure, which in a physiological sense corresponds to the peak of the diastolic phase of the cardiac cycle. The height of the dicrotic wave physiologically indicates the elasticity of the arteries and the closing speed of the aortic valve. If the dicrostic wave peak is higher, it means that the elasticity of the arteries is better, and the closing function of the aortic valve is normal; if the height of the dicrotic wave is lower, it means that the elasticity of the arteries is worse, and the closing function of the aortic valve is abnormal, and there are Arteriosclerotic tendencies.
实施例二:如图6所示,对于CPR成功率进行实时评估。颈动脉超声可以对进行实时的反应,可以对低心排血量和无射血两种情况进行有效的鉴别,并且在CRP时对颈动脉血流速度、流量进行测量是至关重要的。本实施方式在该场景下的应用主要分为两种:(1)提供抢救成功的预测:每5次按压循环后,本柔性传感器阵列评估患者是否恢复自主循环。如果实现自主循环恢复(ROSC)且稳定,则发出通知,医生可以停止CPR。否则,医生可继续按压。(2)本传感器可复合自动心肺复苏仪,并对提供实时的可变全自动按压节律以及按压压力调整。Embodiment 2: As shown in Figure 6, the CPR success rate is evaluated in real time. Carotid artery ultrasound can provide real-time response and can effectively differentiate between low cardiac output and no ejection, and it is crucial to measure carotid artery blood flow velocity and flow during CRP. The application of this implementation method in this scenario is mainly divided into two types: (1) Provide prediction of successful rescue: after every 5 compression cycles, the flexible sensor array evaluates whether the patient has restored spontaneous circulation. If return of spontaneous circulation (ROSC) is achieved and stable, a notification is sent and the physician can discontinue CPR. Otherwise, the doctor can continue compressions. (2) This sensor can be combined with an automatic cardiopulmonary resuscitation instrument and provide real-time variable automatic compression rhythm and compression pressure adjustment.
实施方式九、本实施方式提供了计算机储存介质,用于储存计算机程序,当所述计算机程序被计算机读取时,所述计算机执行实施方式六至七任意一项提供的方法。Embodiment 9. This embodiment provides a computer storage medium for storing a computer program. When the computer program is read by a computer, the computer executes the method provided in any one of Embodiments 6 to 7.
实施方式十、本实施方式提供了计算机,包括处理器和储存介质,当所述处理器读取所述储存介质中储存的计算机程序时,所述计算机执行实施方式六至七任意一项提供的方法。Embodiment 10. This embodiment provides a computer, including a processor and a storage medium. When the processor reads the computer program stored in the storage medium, the computer executes the method provided in any one of Embodiments 6 to 7. method.
以上通过几个具体实施方式对本发明提供的技术方案进行进一步详细地描述,是为了突出本发明提供的技术方案的优点和有益之处,不过以上所述的几个具体实施方式并不用于作为对本发明的限制,任何基于本发明的精神和原则范围内的,对本发明的合理修改和改进、实施方式的组合和等同替换等,均应当包含在本发明的保护范围之内。The technical solutions provided by the present invention are further described in detail through several specific embodiments in order to highlight the advantages and benefits of the technical solutions provided by the present invention. However, the several specific embodiments described above are not intended to serve as a reference to the technical solutions provided by the present invention. Limitations of the invention: Any reasonable modifications and improvements, combinations of embodiments and equivalent substitutions of the invention based on the spirit and principles of the invention shall be included in the protection scope of the invention.
在本说明书的描述中,仅为本发明的较佳实施例,不能以此限定本发明之权利范围;另外,参考术语“一个实施方式”、“一些实施方式”、“示例”、“具体示例”、或“一些示例”等的描述意指结合该实施例或示例描述的具体特征、结构、材料或者特点包含于本发明的至少一个实施例或示例中。在本说明书中,对上述术语的示意性表述不必须针对的是相同的实施例或示例。而且,描述的具体特征、结构、材料或者特点可以在任一个或N个实施例或示例中以合适的方式结合。此外,在不相互矛盾的情况下,本领域的技术人员可以将本说明书中描述的不同实施例或示例以及不同实施例或示例的特征进行结合和组合。此外,术语“第一”、“第二”仅用于描述目的,而不能理解为指示或暗示相对重要性或者隐含指明所指示的技术特征的数量。由此,限定有“第一”、“第二”的特征可以明示或者隐含地包括至少一个该特征。在本发明的描述中,“N个”的含义是至少两个,例如两个,三个等,除非另有明确具体的限定。流程图中或在此以其他方式描述的任何过程或方法描述可以被理解为,表示包括一个或更N个用于实现定制逻辑功能或过程的步骤的可执行指令的代码的模块、片段或部分,并且本发明的优选实施方式的范围包括另外的实现,其中可以不按所示出或讨论的顺序,包括根据所涉及的功能按基本同时的方式或按相反的顺序,来执行功能,这应被本发明的实施例所属技术领域的技术人员所理解。在流程图中表示或在此以其他方式描述的逻辑和/或步骤,例如,可以被认为是用于实现逻辑功能的可执行指令的定序列表,可以具体实现在任何计算机可读介质中,以供指令执行系统、装置或设备(如基于计算机的系统、包括处理器的系统或其他可以从指令执行系统、装置或设备取指令并执行指令的系统)使用,或结合这些指令执行系统、装置或设备而使用。就本说明书而言,“计算机可读介质”可以是任何可以包含、存储、通信、传播或传输程序以供指令执行系统、装置或设备或结合这些指令执行系统、装置或设备而使用的装置。计算机可读介质的更具体的示例(非穷尽性列表)包括以下:具有一个或N个布线的电连接部(电子装置),便携式计算机盘盒(磁装置),随机存取存储器(RAM),只读存储器(ROM),可擦除可编辑只读存储器(EPROM或闪速存储器),光纤装置,以及便携式光盘只读存储器(CDROM)。另外,计算机可读介质甚至可以是可在其上打印所述程序的纸或其他合适的介质,因为可以例如通过对纸或其他介质进行光学扫描,接着进行编辑、解译或必要时以其他合适方式进行处理来以电子方式获得所述程序,然后将其存储在计算机存储器中。应当理解,本发明的各部分可以用硬件、软件、固件或它们的组合来实现。在上述实施方式中,N个步骤或方法可以用存储在存储器中且由合适的指令执行系统执行的软件或固件来实现。如,如果用硬件来实现和在另一实施方式中一样,可用本领域公知的下列技术中的任一项或他们的组合来实现:具有用于对数据信号实现逻辑功能的逻辑门电路的离散逻辑电路,具有合适的组合逻辑门电路的专用集成电路,可编程门阵列(PGA),现场可编程门阵列(FPGA)等。The description in this specification is only a preferred embodiment of the present invention, which cannot limit the scope of rights of the present invention; in addition, refer to the terms "one embodiment", "some embodiments", "example", "specific example" "," or "some examples" or the like means that a specific feature, structure, material or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the schematic expressions of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the specific features, structures, materials or characteristics described may be combined in any suitable manner in any one or N embodiments or examples. Furthermore, those skilled in the art may combine and combine different embodiments or examples and features of different embodiments or examples described in this specification unless they are inconsistent with each other. In addition, the terms “first” and “second” are used for descriptive purposes only and cannot be understood as indicating or implying relative importance or implicitly indicating the quantity of indicated technical features. Therefore, features defined as "first" and "second" may explicitly or implicitly include at least one of these features. In the description of the present invention, "N" means at least two, such as two, three, etc., unless otherwise clearly and specifically limited. Any process or method descriptions in flowcharts or otherwise described herein may be understood to represent modules, segments, or portions of code that include one or more executable instructions for implementing customized logical functions or steps of the process. , and the scope of the preferred embodiments of the invention includes additional implementations in which functions may be performed out of the order shown or discussed, including in a substantially simultaneous manner or in the reverse order, depending on the functionality involved, which shall It should be understood by those skilled in the art to which embodiments of the present invention belong. The logic and/or steps represented in the flowcharts or otherwise described herein, for example, may be considered a sequenced list of executable instructions for implementing the logical functions, and may be embodied in any computer-readable medium, For use by, or in combination with, instruction execution systems, devices or devices (such as computer-based systems, systems including processors or other systems that can fetch instructions from and execute instructions from the instruction execution system, device or device) or equipment. For the purposes of this specification, a "computer-readable medium" may be any device that can contain, store, communicate, propagate, or transport a program for use by or in connection with an instruction execution system, apparatus, or device. More specific examples (non-exhaustive list) of computer readable media include the following: electrical connections with one or N wires (electronic device), portable computer disk cartridges (magnetic device), random access memory (RAM), Read-only memory (ROM), erasable and programmable read-only memory (EPROM or flash memory), fiber optic devices, and portable compact disc read-only memory (CDROM). Additionally, the computer-readable medium may even be paper or other suitable medium on which the program may be printed, as the paper or other medium may be optically scanned, for example, and subsequently edited, interpreted, or otherwise suitable as necessary. process to obtain the program electronically and then store it in computer memory. It should be understood that various parts of the present invention may be implemented in hardware, software, firmware, or a combination thereof. In the above embodiments, the N steps or methods may be implemented using software or firmware stored in a memory and executed by a suitable instruction execution system. For example, if it is implemented in hardware, as in another embodiment, it can be implemented by any one of the following technologies known in the art or their combination: discrete logic gate circuits with logic functions for implementing data signals. Logic circuits, application specific integrated circuits with suitable combinational logic gates, programmable gate arrays (PGA), field programmable gate arrays (FPGA), etc.
本技术领域的普通技术人员可以理解实现上述实施例方法携带的全部或部分步骤是可以通过程序来指令相关的硬件完成,所述的程序可以存储于一种计算机可读存储介质中,该程序在执行时,包括方法实施例的步骤之一或其组合。此外,在本发明各个实施例中的各功能单元可以集成在一个处理模块中,也可以是各个单元单独物理存在,也可以两个或两个以上单元集成在一个模块中。上述集成的模块既可以采用硬件的形式实现,也可以采用软件功能模块的形式实现。所述集成的模块如果以软件功能模块的形式实现并作为独立的产品销售或使用时,也可以存储在一个计算机可读取存储介质中。Those of ordinary skill in the art can understand that all or part of the steps involved in implementing the methods of the above embodiments can be completed by instructing relevant hardware through a program. The program can be stored in a computer-readable storage medium. The program can be stored in a computer-readable storage medium. When executed, one of the steps of the method embodiment or a combination thereof is included. In addition, each functional unit in various embodiments of the present invention can be integrated into a processing module, or each unit can exist physically alone, or two or more units can be integrated into one module. The above integrated modules can be implemented in the form of hardware or software function modules. If the integrated module is implemented in the form of a software function module and sold or used as an independent product, it can also be stored in a computer-readable storage medium.
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