CN117282024B - Electric field emission system - Google Patents
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- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
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Abstract
The application relates to an electric field emission system, which comprises a detection device, an emission device, a control device and an electrode, wherein the electrode is connected with the detection device and the emission device, and the control device is connected with the detection device and the emission device, wherein: the detection device is used for detecting the target tissue through the electrode, determining the real-time state of the target tissue and sending the real-time state to the control device; the control device is used for receiving the real-time state, determining an electric field emission scheme based on the real-time state, generating a control signal based on the electric field emission scheme and sending the control signal to the emission device; the transmitting device is used for driving the electrode based on the control signal, so that the electrode applies a corresponding electric field to the target tissue. The electric field emission system of the application effectively improves the treatment efficiency and further improves the treatment effect. On the other hand, the electric field emission system of the application also makes the treatment process more efficient and simple, and improves the comfort level of patients in the treatment process to a certain extent.
Description
Technical Field
The application relates to the technical field of electronic equipment for medical treatment, in particular to an electric field emission system.
Background
Tumor electric field therapy (TTF) is a tumor therapy performed by portable, noninvasive medical devices, and is based on the principle that a low-intensity, medium-frequency alternating electric field acts on tubulin of proliferating cancer cells to interfere with tumor cell mitosis, so that the affected cancer cells apoptosis and inhibit tumor growth. Electrical impedance imaging (EIT) is a non-invasive technique for reconstructing in vivo tissue images targeting resistivity distributions inside the human body. The human body can be regarded as a large bioelectric conductor, each tissue and each organ have certain impedance, and when the local organ of the human body is diseased, the impedance of the diseased region can be correspondingly changed, so that the diseased condition of the human organ can be diagnosed by measuring the electrical impedance.
However, in the conventional technology, tumor electric field treatment and electrical impedance imaging are generally two independent processes, for example, after tumor electric field treatment is performed on a tumor patient, electrical impedance imaging is performed separately to determine a treatment result, and then tumor electric field treatment equipment and parameters are adjusted and set accordingly according to the treatment result. The treatment process is difficult to timely feed back the treatment effect, is tedious, and results in lower treatment efficiency, and then the treatment opportunity of the patient can be musied.
Disclosure of Invention
In view of the above, it is desirable to provide an electric field emission system capable of improving the therapeutic efficiency.
An electric field emission system, includes detection device, emitter, controlling means and electrode, the electrode with detection device and emitter link to each other, controlling means with detection device and emitter link to each other, wherein:
the detection device is used for detecting target tissues through the electrodes, determining the real-time state of the target tissues and sending the real-time state to the control device;
The control device is used for receiving the real-time state, determining an electric field emission scheme based on the real-time state, generating a control signal based on the electric field emission scheme and sending the control signal to the emission device;
The transmitting means is for driving the electrodes based on the control signal such that the electrodes apply a corresponding electric field to the target tissue.
In one embodiment, the detection device comprises an excitation selection module for detecting target tissue by the electrode based on a preset electrode excitation pattern, wherein the preset electrode excitation pattern comprises adjacent excitation or opposite excitation.
In one embodiment, the detection device comprises a receiving module for receiving a detection feedback signal to the target tissue based on a neighboring receiving mode.
In one embodiment, the emitting device includes a drive voltage control module for generating a voltage waveform that drives the electrodes.
In one embodiment, the voltage waveform comprises an SPWM waveform and the drive voltage control module comprises a direct digital frequency composite signal generator or FPGA.
In one embodiment, the system further includes a host computer, the host computer is connected with the control device, the control device is further configured to send the real-time status to the host computer, and the host computer is configured to generate a real-time image of the target tissue based on the real-time status.
In one embodiment, the electrodes comprise a first number of electrode pairs, and the transmitting means comprises a transmitting electrode selection module for driving a second number of electrode pairs based on the control signal, the second number being not greater than the first number.
In one embodiment, the real-time state comprises a current detected electrical impedance of the target tissue, the determining the electric field emission scheme based on the real-time state comprises,
The transmission scheme is determined based on the difference between the current detected electrical impedance and the previous detected electrical impedance.
In one embodiment, the real-time state includes a first detected electrical impedance of the target tissue in a current time domain, and the determining the electric field emission scheme based on the real-time state includes:
Determining a second detected electrical impedance of the target tissue in the historical time domain;
A transmission scheme is determined based on a first difference of the first detected electrical impedance and the second detected electrical impedance, the transmission scheme including an electric field strength.
In one embodiment, the real-time state includes a first detected electrical impedance difference value of a first preset frequency interval and a second detected electrical impedance difference value of a second preset frequency interval of the target tissue in a current frequency domain, and determining the electric field emission scheme based on the real-time state includes:
Determining a second difference of the first detected electrical impedance difference and a second detected electrical impedance difference;
Determining a third detected electrical impedance difference value of a third preset frequency interval and a fourth detected electrical impedance difference value of a fourth preset frequency interval of the target tissue in a historical frequency domain, and determining a third difference value of the third detected electrical impedance difference value and the fourth detected electrical impedance difference value;
And determining a transmission scheme based on a fourth difference value of the second difference value and the third difference value, wherein the transmission scheme comprises an electric field frequency, and the magnitude of the fourth difference value is inversely related to the magnitude of the electric field frequency.
In one embodiment, the emission scheme includes electrode excitation mode, emission voltage amplitude, electric field strength, electric field frequency.
In one embodiment, the electrodes include a third number of first electrode pads for detecting target tissue and a fourth number of second electrode pads for applying a corresponding electric field to the target tissue.
The electric field emission system comprises a detection device, an emission device, a control device and an electrode, wherein the electrode is connected with the detection device and the emission device, and the control device is connected with the detection device and the emission device, wherein: the detection device is used for detecting target tissues through the electrodes, determining the real-time state of the target tissues and sending the real-time state to the control device; the control device is used for receiving the real-time state, determining an electric field emission scheme based on the real-time state, generating a control signal based on the electric field emission scheme and sending the control signal to the emission device; the transmitting means is for driving the electrodes based on the control signal such that the electrodes apply a corresponding electric field to the target tissue. The application determines the state of the target tissue in real time through the detection device, adjusts the electric field emission scheme in time according to the real-time state, and then drives the electrode to apply an electric field to the target tissue by the emission device. The electric field emission system uses the same electrode to detect and treat the target tissue, and can timely adjust the treatment scheme according to the real-time state of the target tissue, thereby effectively improving the treatment efficiency and further improving the treatment effect. On the other hand, the electric field emission system of the application also makes the treatment process more efficient and simple, and improves the comfort level of patients in the treatment process to a certain extent.
The details of one or more embodiments of the application are set forth in the accompanying drawings and the description below to provide a more thorough understanding of the other features, objects, and advantages of the application.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments or the conventional techniques of the present application, the drawings required for the descriptions of the embodiments or the conventional techniques will be briefly described below, and it is apparent that the drawings in the following description are only some embodiments of the present application, and other drawings may be obtained according to the drawings without inventive effort for those skilled in the art.
FIG. 1 is a schematic diagram of an electric field emission system in one embodiment;
FIG. 2 is a schematic diagram of a detection device in one embodiment;
FIG. 3 is a schematic diagram of a transmitting device in one embodiment;
FIG. 4 is a schematic diagram of an electrode in one embodiment;
FIG. 5 is a schematic view of an electrode in another embodiment;
FIG. 6 is a schematic view of an electrode in another embodiment;
Fig. 7 is a schematic view of an electrode in another embodiment.
Detailed Description
In order that the application may be readily understood, a more complete description of the application will be rendered by reference to the appended drawings. Embodiments of the application are illustrated in the accompanying drawings. This application may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, technical or scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terms "a," "an," "the," "these" and similar terms in this application are not intended to be limiting in number, but may be singular or plural. The terms "comprising," "including," "having," and any variations thereof, as used herein, are intended to encompass non-exclusive inclusion; for example, a process, method, and system, article, or apparatus that comprises a list of steps or modules (units) is not limited to the list of steps or modules (units), but may include other steps or modules (units) not listed or inherent to such process, method, article, or apparatus. The terms "connected," "coupled," and the like in this disclosure are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. The term "plurality" as used herein means two or more. "and/or" describes an association relationship of an association object, meaning that there may be three relationships, e.g., "a and/or B" may mean: a exists alone, A and B exist together, and B exists alone. Typically, the character "/" indicates that the associated object is an "or" relationship. The terms "first," "second," "third," and the like, as referred to in this disclosure, merely distinguish similar objects and do not represent a particular ordering for objects.
Spatially relative terms, such as "under", "below", "beneath", "under", "above", "over" and the like, may be used herein to describe one element or feature's relationship to another element or feature as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use and operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements or features described as "under" or "beneath" other elements would then be oriented "on" the other elements or features. Thus, the exemplary terms "below" and "under" may include both an upper and a lower orientation. Furthermore, the device may also include an additional orientation (e.g., rotated 90 degrees or other orientations) and the spatial descriptors used herein interpreted accordingly.
It will be understood that when an element is referred to as being "connected" to another element, it can be directly connected to the other element or be connected to the other element through intervening elements. Further, "connection" in the following embodiments should be understood as "electrical connection", "communication connection", and the like if there is transmission of electrical signals or data between objects to be connected.
In an embodiment of the present application, as shown in fig. 1, there is provided an electric field emission system 100, the system including a detection device 101, an emission device 102, a control device 103, and an electrode 104, the electrode 104 being connected to the detection device 101 and the emission device 102, the control device 103 being connected to the detection device 101 and the emission device 102, wherein: the detection device 101 is configured to detect a target tissue through the electrode 104, determine a real-time state of the target tissue, and send the real-time state to the control device 103; the control device 103 is configured to receive the real-time status, determine an electric field emission scheme based on the real-time status, generate a control signal based on the electric field emission scheme, and send the control signal to the emission device 102; the transmitting means 102 is configured to drive the electrode 104 based on the control signal such that the electrode 104 applies a corresponding electric field to the target tissue.
In embodiments of the application, the target tissue may comprise a target treatment area, a target organ, or target cells within the living being. In some embodiments, the target tissue may include diseased organs, diseased tissue, tumor cells, etc., and in other embodiments, the target tissue may also include tissue that is free of organisms, etc., as the application is not limited in this regard.
In the embodiment of the application, the detection device is used for detecting the target tissue through the electrode and determining the real-time state of the target tissue. In some embodiments, detecting the target tissue with the electrode may include applying a measuring electric field to the target tissue with the electrode, acquiring a current detected electrical impedance of the target region, and determining a real-time state of the target tissue based on the current detected electrical impedance. The electrical impedance of the target region may be different at different growth states of the target region, such as the state of tumor cells at different times, and at different stages of tumor electric field treatment of the target region, so that the real-time state of the target tissue may be determined based on the current detected electrical impedance of the target region. In other embodiments, the detection device may also determine the real-time status by acquiring other current detection signals of the target area, such as the current detection voltage, the current detection current, and the like, which is not particularly limited by the present application. After the detection device determines the real-time state of the target tissue, the real-time state is sent to the control device.
In the embodiment of the application, the control device may include an MCU (micro control unit) for receiving the real-time state sent by the detection device and determining the electric field emission scheme based on the real-time state. In some embodiments, the real-time state comprises a current detected electrical impedance of the target tissue, and the determining the electric field emission scheme based on the real-time state comprises determining the emission scheme based on a difference between the current detected electrical impedance and a previous detected electrical impedance. The emission scheme comprises an electrode excitation mode, an emission voltage amplitude, an electric field strength and an electric field frequency. In some embodiments, after determining the difference Δz between the current detected electrical impedance and the previous detected electrical impedance, the control device determines a lesion level of the target tissue based on Δz, and then determines the emission plan based on the lesion level. For example, if the target tissue is tumor tissue, if Δz < 0, then determining that the target tissue is increased and the degree of lesions is increased; if ΔZ > 0, it is determined that the target tissue is decreased and the lesion degree is decreased. In other embodiments, positive and negative thresholds may also be set, and if the negative threshold < Δz < positive threshold, then the target tissue is considered unchanged and the extent of the lesion unchanged.
In some embodiments, if the target tissue is reduced and the lesion level is reduced, the pre-emission scheme may be considered to have better therapeutic effect, and a higher-intensity emission scheme is appropriately selected or the original emission scheme is kept unchanged; the target tissue may also be considered to be at the end of treatment, with a treatment regimen of greater intensity no longer being required and a lower intensity firing regimen being selected. If the target tissue is increased and the lesion degree is increased, the treatment intensity of the previous emission scheme can be considered to be not up to the treatment effect, and the emission scheme with higher intensity is properly selected; the previous firing regimen may also be considered less effective and other regimens replaced. If the target tissue is unchanged and the lesion degree is unchanged, the treatment intensity of the previous emission scheme can be considered to be not up to the treatment effect, and the emission scheme with higher intensity is properly selected; it is also contemplated that the previous firing protocol has no effect on the target tissue, replacing other treatment protocols; alternatively, the follow-up firing protocol may be determined after the treatment is continued and the real-time state of the target tissue is continuously observed. Selecting a higher intensity emission scheme may include increasing at least one of a voltage amplitude, an electric field strength, or an electric field frequency in the emission scheme; selecting a lower intensity emission scheme may include reducing at least one of a voltage amplitude, an electric field strength, or an electric field frequency in the emission scheme; changing other emission schemes may include changing electrode excitation patterns and determining voltage amplitude, field strength, or field frequency accordingly. After the control device determines the electric field emission scheme, a control signal is generated based on the electric field emission scheme and transmitted to the emission device.
In some embodiments, the transmission scheme may also be determined based on detecting changes in electrical impedance in different time domains or different frequency domains. The real-time state includes a first detected electrical impedance of the target tissue in a current time domain, and the determining an electric field emission scheme based on the real-time state includes: determining a second detected electrical impedance of the target tissue in the historical time domain; a transmission scheme is determined based on a first difference of the first detected electrical impedance and the second detected electrical impedance, the transmission scheme including an electric field strength.
The first detection electrical impedance of the target tissue in the current time domain and the second detection electrical impedance in the historical time domain are determined, then the change of the target tissue generated in the time domain can be reflected based on the first difference value delta Z1 of the first detection electrical impedance and the second detection electrical impedance, and then the emission scheme is timely adjusted according to the first difference value delta Z1, so that the treatment efficiency and the treatment effect can be effectively improved.
In some embodiments, the real-time state includes a first detected electrical impedance difference value of a first preset frequency interval and a second detected electrical impedance difference value of a second preset frequency interval of the target tissue in a current frequency domain, and determining the electric field emission scheme based on the real-time state includes: determining a second difference of the first detected electrical impedance difference and a second detected electrical impedance difference; determining a third detected electrical impedance difference value of a third preset frequency interval and a fourth detected electrical impedance difference value of a fourth preset frequency interval of the target tissue in a historical frequency domain, and determining a third difference value of the third detected electrical impedance difference value and the fourth detected electrical impedance difference value; and determining a transmission scheme based on a fourth difference value of the second difference value and the third difference value, wherein the transmission scheme comprises an electric field frequency, and the magnitude of the fourth difference value is inversely related to the magnitude of the electric field frequency. The first frequency interval and the second frequency interval may be set to be the same or different, and the third frequency interval and the fourth frequency interval may be set to be the same or different.
In some embodiments, if the current frequency domain is 200KHz and the first frequency interval and the second frequency interval are both set to 50KHz, it may be determined that the difference Δz12 between the first detected electrical impedance of the target tissue in the current frequency domain is 250KHz and the detected electrical impedance corresponding to 200KHz, and the difference Δz11 between the second detected electrical impedance is 200KHz and the detected electrical impedance corresponding to 150KHz, and further determining the second difference Δz2=Δz12- Δz11. Similarly, a third difference Δz3=Δz22- Δz21 is determined in the historical frequency domain. And determining an emission scheme based on a fourth difference Δz4=Δz2- Δz3 of the second difference Δz2 and the third difference Δz3, the emission scheme including an electric field frequency, the magnitude of the third difference being inversely related to the magnitude of the electric field frequency in the emission scheme.
In an embodiment of the application, the transmitting device is used for driving the electrode based on the control signal, so that the electrode applies the corresponding electric field to the target tissue. Wherein the electric field comprises a safe electric field applied to the target tissue that meets the therapeutic requirements. The transmitting means may also be adapted to determine information such as electrode status and target tissue temperature and feed it back to the control means, which may also be adapted to determine the transmission scheme based on this information.
The application determines the state of the target tissue in real time through the detection device, adjusts the electric field emission scheme in time according to the real-time state, and then drives the electrode to apply an electric field to the target tissue by the emission device. The electric field emission system uses the same electrode to detect and treat the target tissue, and can timely adjust the treatment scheme according to the real-time state of the target tissue, thereby effectively improving the treatment efficiency and further improving the treatment effect. On the other hand, the electric field emission system of the application also makes the treatment process more efficient and simple, and improves the comfort level of patients in the treatment process to a certain extent.
The detection device is further described below by way of an embodiment of the present application. As shown in fig. 2, the detection device includes an excitation selection module for detecting a target tissue through the electrode based on a preset electrode excitation pattern, wherein the preset electrode excitation pattern includes adjacent excitation or opposite excitation. Adjacent excitation may include controlling adjacent electrode pads to apply excitation signals to the target area continuously or at intervals. The counter-excitation may include controlling the opposing electrode pads to apply excitation signals to the target area continuously or at intervals. In some embodiments, the detection accuracy of adjacent excitations is higher if the tumor location is in a superficial region; if the tumor position is in the central area, the opposite excitation detection accuracy is higher. The detection device further includes a receiving module for receiving a detection feedback signal to the target tissue based on a neighboring reception mode. The adjacent receiving mode may include controlling adjacent electrode pads to receive the detection signal of the target tissue.
In some specific embodiments, as shown in fig. 2, the detection device may further include an excitation arm and a feedback arm, where the excitation arm is connected to the control device and the electrode, respectively, and the feedback arm is connected to the control device and the electrode, respectively. The excitation branch circuit comprises a digital-to-analog converter, a first filter, a first operational amplifier, a voltage-controlled constant current source and an excitation selection module which are sequentially connected. The feedback branch circuit comprises a receiving module, an instrument amplifier, a second filter, a second operational amplifier and an analog-to-digital converter which are sequentially connected from the electrode side to the control device side. The digital-analog converter is used for generating an excitation signal with a preset frequency based on the detection signal sent by the receiving control device and used for improving the precision of the excitation signal. The first filter is for filtering the excitation signal based on a low pass or band pass mode. The first operational amplifier is used for amplifying the excitation signal. The voltage controlled constant current source may be configured as a monopolar common ground or bipolar floating constant current source for providing a high output impedance for the excitation signal. The instrumentation amplifier is configured to receive the probe signal and provide a high CMRR (common mode rejection ratio) and a high input impedance for the probe signal. The second filter is used to filter the detection signal based on a low pass or band pass mode. The second operational amplifier is used for amplifying the detection signal, and the second operational amplifier can amplify the detection signal based on a VGA (Video GRAPHICS ARRAY) mode. The analog-to-digital converter is used for converting the detection signal into a digital signal and sending the digital signal to the control device, so that the signal transmission efficiency is improved.
The transmitting device is further described below by way of embodiments of the present application. As shown in fig. 3, the emitting device includes a driving voltage control module for generating a voltage waveform for driving the electrodes. The voltage waveform comprises an SPWM waveform, and the driving voltage control module comprises a direct digital frequency synthesis signal generator or FPGA and is used for generating a driving voltage with the waveform of the SPWM based on the direct digital frequency synthesis signal generator (DDS) or generating a driving voltage with the waveform of the SPWM based on the FPGA. In other embodiments, the voltage waveform may further include a PWM waveform, and the driving voltage control module may further include a single chip microcomputer or an FPGA, for generating a driving voltage having a waveform of PWM based on the single chip microcomputer or the FPGA. Accordingly, the drive voltage control module may include an SPWM waveform generator and a PWM waveform generator. The SPWM waveform generator is used for generating the driving voltage of the SPWM waveform, the target waveform and the triangular waveform can be generated through the DDS, the driving voltage of the SPWM waveform can be generated through the third operational amplifier, and the driving voltage of the SPWM waveform can be directly generated according to a preset algorithm based on the FPGA. The PWM waveform generator is used for generating the driving voltage of the PWM waveform, and can generate the PWM driving voltage based on the PWM generating chip, wherein the PWM chip can comprise a preset PWM chip or a singlechip, and can also directly generate the driving voltage of the PWM waveform based on the FPGA according to a preset algorithm.
In some embodiments, the electrodes include a first number of electrode pairs, and the transmitting device includes a transmitting electrode selection module for driving a second number of electrode pairs based on the control signal, the second number being no greater than the first number. The electrodes may apply an electric field to the target tissue in the form of electrode pairs. The transmitting device may control the second number of electrode pairs to apply an electric field to the target tissue, for example, if the electrodes include 6 pairs of electrodes (12 electrode pads), the transmitting device may control any one of 2 pairs of electrodes (4 electrode pads), 4 pairs of electrodes (8 electrode pads), 6 pairs of electrodes (12 electrode pads), and the like to apply an electric field to the target tissue.
In some specific embodiments, as shown in fig. 3, the transmitting device includes a driving voltage control module, a driver, an inverter, a filtering module, an isolation transformer, and a transmitting electrode selection module, which are sequentially connected, and the transmitting electrode selection module is connected with the electrode; the emission device further comprises an acquisition module, a power module and a buck-boost module, wherein the buck-boost module is respectively connected with the power module and the inverter, and the acquisition module is connected with the electrode. The step-up and step-down module, the acquisition module and the driving voltage control module are also connected with the control device. The power supply module is used for supplying power to the transmitting device, and can be used for supplying power to the external adapter or an internal battery. The step-up and step-down module is used for carrying out step-up or step-down processing on the power supply voltage provided by the power supply module, the step-up or step-down can be controlled by the control device, and a switching power supply can be used. The driver is used for increasing the driving voltage, and the SPWM waveform or PWM waveform driving voltage output by the driving voltage module is increased and then is transmitted to the inverter. The inverter is used for converting the direct-current driving voltage output by the driver into alternating-current driving voltage. The filtering module is used for filtering the alternating current driving voltage generated by the inverter, eliminating high-frequency voltage and filtering based on a low-pass filtering mode. The isolation transformer is used for boosting the alternating current driving voltage to enable the boosted alternating current driving voltage to reach the target voltage capable of acting on the target tissue, and is also used for isolating the primary and the secondary of the transformer to avoid the influence and harm to the target tissue caused by the action of a power supply connected with the primary network on the secondary electrode. The acquisition module is used for acquiring information such as electrode state and target tissue temperature.
The electrodes are further described below by way of examples of the present application. The electrode comprises a third number of first electrode pads for detecting a target tissue and a fourth number of second electrode pads for applying a corresponding electric field to the target tissue.
In the embodiment of the application, the electrode can comprise a preset number of electrode plates. In some embodiments, the electrode pads may be divided into a third number of electrode pads for detecting target tissue and a fourth number of electrode pads for applying a corresponding electric field to the target tissue. In other embodiments, all electrode pads may also be used for detection of target tissue or a corresponding electric field may be applied to the target tissue by timing control. For example, in some embodiments, the electrodes may be configured to stop for m time after the corresponding electric field is applied to the target tissue for n time, then detect the target tissue to determine a real-time state of the target tissue, then determine an electric field emission scheme based on the real-time state, apply the corresponding electric field to the target tissue, and repeat the steps described above. Wherein n may be set to not less than 1 minute.
In some embodiments, the electrodes may be arranged as shown in fig. 4, and the electrode pads for applying the corresponding electric field to the target tissue may include ceramic pad regions shown as TTF electrodes 1-9, the entire regions including biocompatible conductive glue, and the 9 ceramic pads are connected to the temperature measuring unit, respectively. The electrodes used to detect the target tissue include two separate electrodes E1 and E2, each provided with a biocompatible low impedance (50 KHz) conductive material, each provided with a separate electrode wire to prevent interference. The wiring arrangement may be 200KHz electric field input line, electrode temperature output line, and ground.
In other embodiments, the electrodes may also be arranged as shown in fig. 5, and the electrode pad for applying the corresponding electric field to the target tissue may comprise 1-7 ceramic pad areas, the entire areas comprising biocompatible conductive glue, the 7 ceramic pads being connected to the temperature measuring unit, respectively. The electrodes used for detecting the target tissue comprise two independent electrodes E1 and E2, each electrode is provided with a biocompatible low-impedance (50 KHz) conductive material, and each electrode is provided with an independent electrode wire to prevent interference. The wiring arrangement may be 200KHz electric field input line, electrode temperature output line, and ground.
In other embodiments, the electrodes may also be arranged as shown in fig. 6, and the electrode pads for applying the corresponding electric field to the target tissue may comprise ceramic pad areas shown by TTF electrodes 1-9, the entire areas comprising biocompatible conductive glue, the 9 ceramic pads being connected to the temperature measuring unit, respectively. The electrode for detecting the target tissue comprises 1-9 independent electrodes, each electrode is provided with an independent electrode wire for preventing interference, the front end of the electrode wire is fused with a TTF electrode wire, the 9 independent electrode wires and TTF electrode wire can be input for selection, and the EIT working mode is carried out in a ceramic plate mode.
In other embodiments, the electrodes may also be arranged as shown in fig. 7, and the electrode pad for applying the corresponding electric field to the target tissue may comprise 1-8 ceramic pad areas, the entire areas comprising biocompatible conductive glue, and the 8 ceramic pads are respectively connected to the temperature measuring unit. The electrodes used to probe the target tissue include individual electrodes E1, each of which is provided with a biocompatible low impedance (50 KHz) conductive material, and each of which is provided with individual electrode wires to prevent interference. The wiring arrangement may be 200KHz electric field input line, electrode temperature output line, and ground. In the embodiment, the electrodes are uniformly distributed, so that the positioning accuracy and the detection accuracy of target tissues can be improved.
In the embodiment of the application, the system further comprises an upper computer, the upper computer is connected with the control device, the control device is further used for sending the real-time state to the upper computer, and the upper computer is used for generating a real-time image of the target tissue based on the real-time state.
In some embodiments, the upper computer generating the real-time image of the target tissue based on the real-time state may include generating the real-time image of the target tissue based on a current detected impedance of the target tissue, and the user may determine a lesion degree of the target tissue and a treatment effect of the electric field emission scheme on the target tissue according to the real-time image. In other embodiments, the user may adjust the treatment plan after determining the lesion level of the target tissue from the real-time image, and the control device determines the electric field emission plan based on the control instruction transmitted from the host computer to the control device.
The operation of the electric field emission system of the present application will be further described with reference to specific examples. The control device can also be connected with an upper computer, and the upper computer is used for storing target tissue information, such as tumor information and the like. The upper computer is also used for sending control signals to the control device based on preset parameters, receiving feedback information sent by the control device and the like. Specifically, the upper computer program sets a working time interval (such as 1 minute) and a detection scheme (such as an excitation mode, an excitation size, electrode selection and the like) of the detection device, the upper computer generates a detection control signal based on the working time interval and the detection scheme and sends the detection control signal to the control device, the control device sends the detection scheme to the detection device based on the working time interval, and the detection device sets circuit output parameters and preset electrode excitation modes based on the detection scheme. The detection device excites the excitation signal to the excitation electrode of the composite electrode, and the other electrodes of the composite electrode receive the feedback signal and send the feedback signal to the detection device. And each electrode rounds a period, the detection device transmits all feedback signal data information to the control device, the control device calculates and analyzes the feedback signal, and the feedback signal is packed into a data packet and transmitted to the upper computer. The upper computer extracts data based on the feedback signals, calculates the electrical impedance variation delta Z according to a preset algorithm, draws images according to a preset imaging algorithm and completely displays the images. The upper computer determines the data characteristics of the target tissue based on the display image and sends the data characteristics to the control device. The control device determines the lesion degree of the target tissue according to the data characteristics and determines an electric field emission scheme. The control device generates a control signal based on the electric field emission scheme and transmits the control signal to the emission device. The transmitting device sets an electrode excitation mode, a transmitting voltage amplitude, an electric field strength and an electric field frequency according to the control signal, and applies an electric field to the target tissue. After a preset time interval, the transmitting device stops working, and the detecting device detects the target tissue again and feeds back information to coordinate with the transmitting device.
The respective devices, modules in the above-described electric field emission system may be implemented in whole or in part by software, hardware, and combinations thereof. The above devices or modules may be embedded in hardware or may be independent of a processor in the computer device, or may be stored in software in a memory in the computer device, so that the processor may call and execute operations corresponding to the above modules. It should be noted that, in the embodiment of the present application, the division of the devices or modules is schematic, which is merely a logic function division, and other division manners may be implemented in actual practice.
The user information (including but not limited to user equipment information, user personal information, etc.) and the data (including but not limited to data for analysis, stored data, presented data, etc.) related to the present application are information and data authorized by the user or sufficiently authorized by each party.
In the description of the present specification, reference to the terms "some embodiments," "other embodiments," "desired embodiments," and the like, means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, schematic descriptions of the above terms do not necessarily refer to the same embodiment or example.
The technical features of the above embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.
The above examples illustrate only a few embodiments of the application, which are described in detail and are not to be construed as limiting the scope of the application. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the application, which are all within the scope of the application. Accordingly, the scope of protection of the present application is to be determined by the appended claims.
Claims (9)
1. An electric field emission system, comprising a detection device, an emission device, a control device and an electrode, wherein the electrode is connected with the detection device and the emission device, and the control device is connected with the detection device and the emission device, wherein:
the detection device is used for detecting target tissues through the electrodes, determining the real-time state of the target tissues and sending the real-time state to the control device;
The control device is used for receiving the real-time state, determining an electric field emission scheme based on the real-time state, generating a control signal based on the electric field emission scheme and sending the control signal to the emission device;
the transmitting device is used for driving the electrode based on the control signal, so that the electrode applies a corresponding electric field to the target tissue;
The real-time state comprises a first detection electrical impedance difference value of a first preset frequency interval and a second detection electrical impedance difference value of a second preset frequency interval of the target tissue in a current frequency domain, and the determining the electric field emission scheme based on the real-time state comprises the following steps:
Determining a second difference of the first detected electrical impedance difference and a second detected electrical impedance difference;
Determining a third detected electrical impedance difference value of a third preset frequency interval and a fourth detected electrical impedance difference value of a fourth preset frequency interval of the target tissue in a historical frequency domain, and determining a third difference value of the third detected electrical impedance difference value and the fourth detected electrical impedance difference value;
And determining a transmission scheme based on a fourth difference value of the second difference value and the third difference value, wherein the transmission scheme comprises an electric field frequency, and the magnitude of the fourth difference value is inversely related to the magnitude of the electric field frequency.
2. The system of claim 1, wherein the detection device comprises an excitation selection module for detecting the target tissue through the electrode based on a preset electrode excitation pattern, wherein the preset electrode excitation pattern comprises adjacent excitation or opposite excitation.
3. The system of claim 1, wherein the detection device comprises a receiving module for receiving a sounding feedback signal to the target tissue based on a neighboring reception pattern.
4. The system of claim 1, wherein the emitting device comprises a drive voltage control module for generating a voltage waveform that drives the electrode.
5. The system of claim 4, wherein the voltage waveform comprises an SPWM waveform and the drive voltage control module comprises a direct digital frequency synthesis signal generator or FPGA.
6. The system of claim 1, further comprising a host computer coupled to the control device, the control device further configured to send the real-time status to the host computer, the host computer configured to generate a real-time image of the target tissue based on the real-time status.
7. The system of claim 1, wherein the electrodes comprise a first number of electrode pairs, and the transmitting means comprises a transmitting electrode selection module for driving a second number of electrode pairs based on the control signal, the second number being no greater than the first number.
8. The system of claim 1, wherein the emission scheme comprises an electrode excitation pattern, an emission voltage amplitude, an electric field strength, an electric field frequency.
9. The system of claim 1, wherein the electrodes comprise a third number of first electrode pads for detecting target tissue and a fourth number of second electrode pads for applying a corresponding electric field to the target tissue.
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