CN117224171A - Sampling capsule, sampling capsule system and control method - Google Patents

Abstract

A sampling capsule, a sampling capsule system and a control method. The sampling capsule comprises a shell, a partition wall arranged in the shell, a sampling pool formed by the partition wall and the shell arranged on the first side of the partition wall in a surrounding manner, an inner sample inlet arranged on the partition wall, an outer sample inlet arranged on the shell and on the second side of the partition wall, a sampling channel communicated with the outer sample inlet and the inner sample inlet, and a switch assembly for opening or closing the sampling channel. When the sampling capsule reaches the digestive tract part to be detected, the sampling channel is opened through the switch assembly, so that sample injection is realized; after the sample injection is finished, closing the sampling channel to prevent the sample from leaking or being polluted; and the sampling amount can be precisely controlled by controlling the opening time of the sampling channel. In addition, the switch component actively controls the opening or closing of the sampling channel, so that the sampling device can be used for any digestive tract part and has high universality.

Description

Sampling capsule, sampling capsule system, and control method

Technical field

This application relates to the technical field of medical devices, and in particular to a sampling capsule, a sampling capsule system, and a control method that are highly versatile, can accurately control sampling time and sampling volume, and can prevent samples from being leaked or contaminated after sampling.

Background technique

The sampling capsule is a smart capsule that enters the digestive tract to sample digestive juice. Normally, the sampling capsule includes a sampling cavity, a sampling port connected to the sampling cavity, and a sampling port; after reaching a specific part of the digestive tract, the sampling port opens, and the digestive juice enters the sampling cavity; after the sampling capsule is removed from the body, it exits from the sampling port The digestive juices were removed for pathological analysis.

In existing sampling capsules, the sampling port is made of materials that are degradable under the environment of a specific part of the digestive tract. When the sampling capsule reaches the corresponding part of the digestive tract, the material degrades to form a sampling hole, allowing the digestive fluid to enter the sample under the pressure difference between the inside and outside. inside the capsule. However, this kind of sampling capsule, on the one hand, has different environments in different digestive tracts, so the versatility of this kind of sampling capsule is poor; on the other hand, the sampling volume is uncontrollable, and after the sampling is completed, the sampling hole cannot be closed again, and the sample is easy to leak or be Contamination from other liquids.

In view of this, it is necessary to provide an improved sampling capsule, sampling capsule system, and control method to solve the above problems.

Contents of the invention

The purpose of the present invention is to provide a sampling capsule, a sampling capsule system and a control method that are highly versatile, can accurately control the sampling time and sampling volume, and can prevent the sample from being leaked or contaminated after sampling.

In order to achieve the above object, the present invention provides a sampling capsule, which includes a shell, a partition wall provided in the shell, and a sampling capsule formed by the partition wall and the shell located on the first side of the partition wall. Pool; It is characterized in that the sampling capsule also includes: an inner sampling inlet provided on the partition wall, an outer sampling inlet provided on the outer shell located on the second side of the partition wall, and an outer sampling inlet connected to the The sampling channel of the outer sampling port and the inner sampling port, and the switch assembly that opens or closes the sampling channel;

Wherein, the wall surrounding the sampling channel includes a first wall and a second wall arranged oppositely, and at least part of the first wall is an elastic wall; the switch assembly exerts force on the elastic wall to adjust the The distance between the elastic wall and the second wall is such that the elastic wall is close to the second wall to close the sampling channel or to open the sampling channel away from the second wall;

The switch assembly includes a driving unit that drives the elastic wall close to the second wall and a control unit that is communicatively connected to the driving unit; the driving unit includes a micromotor that is communicatively connected to the control unit and the The rotor of the micromotor is threadedly connected to the top block; when the rotor rotates, the thread fit is converted into linear motion of the top block, thereby exerting force on the elastic wall.

As a further improvement of the present invention, the top block is not connected to the elastic wall; or the top block is connected to the elastic wall.

As a further improvement of the present invention, the switch assembly further includes a slide rail disposed on the inner wall of the housing to limit the linear movement of the top block.

As a further improvement of the present invention, the micromotor is a motor or a stepper motor, and the micromotor is located on the side of the top block facing away from the elastic wall.

As a further improvement of the present invention, the switch assembly also includes:

A sensor that is communicatively connected to the control unit, the sensor is used to collect physiological parameters and/or image information in the digestive tract; the sensor is at least one of an image sensor, a pH sensor, or an ultrasonic sensor; the sensor When an image sensor is included, part of the housing is transparent; when the sensor includes a pH sensor, the housing has a window, and the pH sensor contacts the digestive tract fluid through the window;

A storage module communicatively connected to the control unit, the storage module is used to store normal physiological parameters and/or image information of different parts of the digestive tract, and physiological parameters and/or image information of possible lesions;

A wireless transmission module used to communicate with external processing terminals.

As a further improvement of the present invention, the partition wall and the shell located on the first side of the partition wall are integrally arranged; or the partition wall and the shell located on the first side of the partition wall are separately arranged. The sealing of the connection should ensure that the sampling pool can maintain the required vacuum degree of -90kPa ~ -80kPa.

As a further improvement of the present invention, the second wall is provided close to the partition wall, the first wall is provided on a side of the sampling channel away from the partition wall, and the outer sampling inlet is provided on the third wall. between one wall and said second wall;

Or, the partition wall constitutes the second wall, the first wall is an elastic wall spaced apart from the partition wall, and the outer sample inlet is provided between the partition wall and the elastic wall, The sampling channel is formed between the elastic wall and the partition wall;

Or, both the first wall and the second wall are elastic walls, and the first wall and the second wall are integrally provided, and the sampling channel is a multi-pass tube, and part of the tube opening is connected to the inner wall. The injection port is connected, and some other pipe ports are connected to the external injection port.

The invention also provides a sampling capsule system, which includes the sampling capsule and an external processing terminal that is communicatively connected to the switch assembly.

The invention also provides a control method based on the sampling capsule, which includes the following steps: determine whether sampling is required, and if so, the switch component opens the sampling channel; after sampling is completed, the switch component closes the sampling channel .

As a further improvement of the present invention, the switch assembly further includes: a sensor that is communicatively connected to the control unit, and the sensor is used to collect physiological parameters and/or image information in the digestive tract; a storage device that is communicatively connected to the control unit. Module, the storage module is used to store normal physiological parameters and/or image information of different parts of the digestive tract, and physiological parameters and/or image information of possible lesions; a wireless transmission module used to communicate with external processing terminals; in,

The sensor is an image sensor, and part of the housing is transparent; an external image of the digestive tract is obtained through the image sensor, and the wireless transmission module transmits the obtained image to an external processing terminal, and the external processing terminal processes the obtained image. Processing, identifying the part of the digestive tract where the sampling capsule is located, whether there is a lesion, and deciding whether to sample based on the information about the part of the digestive tract and whether there is a lesion;

Or, the sensor is a pH sensor, and the housing has a window, and the pH sensor contacts the digestive tract liquid through the window; the pH value of the digestive juice of the digestive tract is obtained through the pH sensor, and the obtained pH value is passed through the The wireless transmission module transmits it to the external processing terminal to process the obtained pH value to determine the position of the sampling capsule, and decide whether to sample according to the location of the digestive tract;

Or, the sensor is an ultrasonic sensor; the external digestive tract image is obtained through the ultrasonic sensor, and the wireless transmission module transmits the obtained image to an external processing terminal, and the external processing terminal processes the obtained image to identify the sample The part of the digestive tract where the capsule is located and whether there is a lesion, and whether to take a sample is decided based on the information about the part of the digestive tract and whether there is a lesion.

Compared with the prior art, the beneficial effects of the present invention are: the sampling capsule of the present invention passes through the switch assembly, and when the sampling capsule reaches the part of the digestive tract to be detected, the sampling channel is opened, and the digestive juice flows in through the outside. The sample port, sampling channel, and inner sampling port enter the sampling pool to implement sampling; after the sampling is completed, the sampling channel is closed to prevent sample leakage or contamination; and by controlling the opening time of the sampling channel, The injection volume can be precisely controlled. In addition, the switch assembly actively controls the opening or closing of the sampling channel, which is not affected by the environment of the digestive tract part, and can be used in any part of the digestive tract, with high versatility.

Description of drawings

Figure 1 is a schematic structural diagram of the sampling capsule according to a preferred embodiment of the present invention when the sampling channel is closed;

Figure 2 is a schematic structural diagram of the sampling capsule shown in Figure 1 when the sampling channel is opened;

Figure 3 is a schematic cross-sectional view of a multi-pass pipe in a preferred embodiment of the present invention;

Figure 4 is a schematic cross-sectional view of a multi-pass pipe in another preferred embodiment of the present invention;

Figure 5 is a schematic structural diagram of the sampling capsule when the sampling channel is opened according to another preferred embodiment of the present invention;

Figure 6 is a schematic structural diagram of the sampling capsule shown in Figure 5 when the sampling channel is closed;

Figure 7 is a schematic structural diagram of the sampling capsule when the sampling channel is opened according to another preferred embodiment of the present invention;

Figure 8 is a schematic structural diagram of the sampling capsule shown in Figure 7 when the sampling channel is closed.

Specific embodiments

The present application will be described in detail below with reference to the specific embodiments shown in the accompanying drawings. However, these embodiments do not limit this application, and any structural, method, or functional changes made by those of ordinary skill in the art based on these embodiments are included in the protection scope of this application.

In the various drawings of this application, certain dimensions of structures or portions are exaggerated relative to other structures or portions for ease of illustration and, therefore, are only used to illustrate the basic structures of the subject matter of this application.

In addition, terms used herein such as "on", "above", "down", "below" and other terms indicating relative positions in space are used for convenience of explanation to describe the relative position of one unit or feature as shown in the drawings. A relationship to another unit or feature. The spatially relative terms may be intended to encompass different orientations of the device in use or operation in addition to the orientation illustrated in the figures. For example, if the device in the diagram is turned over, elements described as "below" or "beneath" other elements or features would then be oriented "above" the other elements or features. Thus, the exemplary term "below" may encompass both upper and lower orientations. The device may be otherwise oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.

Please refer to FIGS. 1 to 8 , which are schematic diagrams of the sampling capsule 100 and its internal structure according to the preferred embodiment of the present invention.

Please refer to Figures 1 to 2 and Figures 5 to 8. The sampling capsule 100 includes a shell 1, a partition wall 2 provided in the shell 1, and the partition wall 2 and the partition wall 2. The housing 1 on the first side surrounds the sampling pool 3 , the inner sampling port 41 provided on the partition wall 2 , and the outer sampling port 41 provided on the housing 1 on the second side of the partition wall 2 . The sampling port 42 , the sampling channel 43 connecting the outer sampling port 42 and the inner sampling port 41 , and the switch assembly 5 that opens or closes the sampling channel 43 .

Generally, when the sampling capsule 100 is in a part of the digestive tract that needs to be inspected, or reaches a part of the digestive tract that has a disease, sampling needs to be performed. When the sampling capsule 100 reaches the part of the digestive tract that needs sampling, the sampling channel 43 is opened through the switch assembly 5 , and the digestive fluid enters the sampling port through the outer sampling port 42 , the sampling channel 43 , and the inner sampling port 41 Pool 3 implements sampling; after the sampling is completed, the sampling channel 43 is closed to prevent sample leakage or contamination; and by controlling the opening time of the sampling channel 43, the injection volume can be accurately controlled. In addition, the switch assembly 5 actively controls the opening or closing of the sampling channel 43, which is not affected by the special environment of the digestive tract, and can be used in any part of the digestive tract, with high versatility.

After the sampling capsule 100 is taken out of the body, the solution for taking out the digestive fluid includes but is not limited to: opening the sampling channel 43 so that the digestive fluid passes through the inner sampling port 41, the sampling channel 43, and the external sampling port. Outflow from port 42 is used for pathological analysis. Alternatively, the sampling capsule 100 further includes a sampling port 6 located on the shell 1 on the first side of the partition wall 2 and connected to the sampling pool 3. The sampling port 6 is made of soft materials such as rubber. Insert a syringe or other equipment into the sampling pool 3 from the sampling port 6 to take a sample.

Specifically, the shell 1 is made of any material that is harmless to the human body and will not be corroded by digestive juices. The length is within 30 mm, such as 27 mm; the diameter is within 12 mm, such as 11.6 mm; so as to be able to enter the digestive tract well. Take samples from any part. Moreover, the housing 1 is formed by splicing at least two parts, which facilitates the installation and installation of the internal structure. For example, as shown in Figure 1, the shell 1 is composed of three parts: a first shell 11, a second shell 12 and a third shell 13 distributed along the length direction of the sampling capsule 100, and the three parts are connected by threads, glue, etc. connect.

The partition wall 2 and the shell 1 located on the first side of the partition wall 2 are integrally arranged, so that the sealing performance of the sampling pool 3 formed is better; or the partition wall 2 and the shell 1 located on the first side of the partition wall 2 are The shell 1 on one side is arranged separately, and the sealing performance of the connection between the two should ensure that the sampling pool 3 can maintain its required vacuum degree.

The sampling pool 3 is a vacuum chamber with a volume greater than 0.3mL, such as 0.4mL~0.7mL; the vacuum degree can be -90kPa~-80kPa, ensuring that the volume of collected digestive fluid is greater than 0.3mL. Before use, the sampling channel 43 is opened, and the air in the sampling pool 3 is extracted through a vacuum. After reaching the required vacuum degree, the sampling channel 43 is closed so that the sampling pool 3 maintains the required vacuum. Spend. During use, when the sampling capsule 100 reaches the required part of the digestive tract, the sampling channel 43 is opened, and the digestive fluid enters the sampling pool 3 under the action of the internal and external pressure difference to complete sampling.

Preferably, the sampling pool 3 is located at one end of the housing 1 in the length direction, and the sampling pool 3, the sampling channel 43, and the switch assembly 5 are arranged in sequence along the length direction of the housing 1, resulting in high space utilization. , and easy to install.

In the present invention, the number of the inner sampling port 41 and the outer sampling port 42 is not limited. Those skilled in the art can understand that "closing the sampling channel" means cutting off all channels between the inner sampling port 41 and the outer sampling port 42 .

When the number of the external sampling inlets 42 is at least two, at least two external sampling inlets 42 are evenly distributed on the housing 1 along the circumferential direction of the housing 1 , and the sampling capsule 100 is surrounded by All digestive juices can enter the sampling pool 3, which can avoid sampling failure caused by the temporary absence of digestive juices or insufficient amount of digestive juices in a specific part of the digestive tract. Of course, at least two external sampling inlets 42 can also be randomly distributed on the housing 1 along the circumferential direction of the housing 1 .

When the number of the inner sampling ports 41 is at least two, at least two of the inner sampling ports 41 are evenly distributed on the partition wall 2; the sampling speed is fast, and the sample entering the sampling pool 3 is The digestive juices are evenly distributed and will not affect the injection due to local stacking of digestive juices. Of course, at least two inner sampling ports 41 can also be randomly distributed on the partition wall 2 .

When the number of the inner sampling port 41 is one and the number of the outer sampling ports 42 is at least two, the inner sampling port 41 and all the external sampling channels are connected simultaneously through one sampling channel 43 . Inlet 42. Specifically, the sampling channel 43 includes several ports that are connected one by one with the inner sampling port 41 and the outer sampling port 42, and are connected through communication tubes in between. Taking an inner sampling port 41 and two outer sampling ports 42 as an example, the sampling channel 43 is T-shaped as shown in FIG. 3 .

When the number of the inner sampling ports 41 is at least two, and the number of the outer sampling ports 42 is at least two, one sampling channel 43 can be used to connect all the inner sampling ports 41 and All external inlets 42. Specifically, the sampling channel 43 has several ports that are connected to the inner sampling port 41 and the outer sampling port 42 one by one, and are connected through connecting pipes in the middle. Taking two inner sampling ports 41 and two outer sampling ports 42 as an example, the sampling channel 43 is connected to the two inner sampling ports 41 and the two outer sampling ports 42 at the same time. The sampling channel 43 is as shown in 4 shown.

When the number of the inner sampling ports 41 is at least two, and the number of the outer sampling ports 42 is at least two, all the inner sampling ports 41 may also be connected through multiple sampling channels 43 At least one inner sampling port 41 and at least one outer sampling port 42 are connected to all the outer sampling ports 42 and each sampling channel 43 . Taking two inner sample inlets 41 and two outer sample inlets 42 as an example, the connection can be achieved through two independent sampling channels 43. One end of each of the sampling channels 43 is connected to one of the inner sample inlets. The port 41 is connected, and the other end is connected with one of the external sampling ports 42 . When the number of the inner sampling ports 41 and the outer sampling ports 42 is inconsistent, the structure of multiple independent sampling channels 43 is determined according to the number of the inner sampling ports 41 and the outer sampling ports 42 connected thereto. For corresponding modifications, reference may be made to the above embodiments for specific structures, which will not be described again here.

In addition, the wall surrounding the sampling channel 43 includes a first wall 431 and a second wall 432 arranged oppositely. At least part of the first wall 431 is an elastic wall; the switch assembly 5 exerts force on the elastic wall. , to adjust the distance between the elastic wall and the second wall 432, so that the elastic wall is close to the second wall 432 to close the sampling channel 43 or to open the sampling channel 43 away from the second wall 432. Describe sampling channel 43. Those skilled in the art can understand that "the switch component 5 exerts force on the elastic wall to adjust the separation distance between the elastic wall and the second wall 432" includes the following two situations: the elasticity The wall adjusts the distance between the elastic wall and the second wall 432 completely under the active control of the switch assembly 5; or in view of the elasticity of the elastic wall itself, the elastic wall adjusts the distance between the elastic wall and the second wall 432 under the active control of the switch assembly 5; The distance between the elastic wall and the second wall 432 is jointly adjusted under the control and the elastic force.

Those skilled in the art can understand that part of the structure of the first wall 431 is an elastic wall, or the entire structure is an elastic wall. When the switch assembly 5 drives the elastic wall to fit with the second wall 432, the switch assembly 5 closes the elastic wall. Sampling channel 43; when the switch assembly 5 does not act on the elastic wall, the elastic wall returns to its original shape under its own elastic force, leaves the second wall 432, and opens the sampling channel 43; or the switch assembly 5 Directly drive the elastic wall away from the second wall 432 to open the sampling channel 43 .

Wherein, as shown in Figures 1 to 4, the first wall 431 and the second wall 432 are both elastic walls, and the first wall 431 and the second wall 432 are integrally provided, and the sampling channel 43 is a multi-pass tube, part of the tube port is connected to the inner sampling port 41, and the other part of the tube port is connected to the outer sampling port 42. The digestion liquid will not cause corrosion to other structures during the entry process. For example, as shown in FIG. 3 , when the sampling capsule 100 is provided with one inner sampling port 41 and two outer sampling ports 42 , the multi-pass tube is T-shaped, and one of its nozzles is connected to the outer sampling port 42 . The inner sampling port 41 is connected, and the other two pipe ports are connected to the two outer sampling ports 42 .

Preferably, the second wall 432 is disposed close to the partition wall 2 , the first wall 431 is disposed on a side of the sampling channel 43 away from the partition wall 2 , and the switch assembly 5 is located on the first wall 431 On the side away from the partition wall 2 , the distance between the first wall 431 and the housing 1 is relatively large, which facilitates the installation and installation of the switch assembly 5 .

In this embodiment, the first shell 11 and the second shell 12 are separated at the outer sampling port 42, and the parts where the sampling port 42 is not provided are bonded through interference fit, threaded connection or glue. The first wall 431 is fixed on the second housing 12, and the second wall 432 is fixed on the first housing 11 to facilitate the installation of the multi-pass pipe.

Alternatively, as shown in FIGS. 5 and 6 , the second wall 432 is the partition wall 2 , the first wall 431 is the elastic wall spaced apart from the partition wall 2 , and the outer sample inlet 42 is provided on The sampling channel 43 is formed between the partition wall 2 and the elastic wall, and between the elastic wall and the partition wall 2 . When the switch assembly 5 drives the elastic wall to fit against the partition wall 2 , the sampling channel 43 can be closed. Preferably, the portion of the elastic wall corresponding to the inner sampling port 41 is fit into place. On the partition wall 2, the inner sampling port 41 can be shielded at the same time, thereby ensuring that the sampling pool 3 is a sealed cavity. In this embodiment, the first housing 11 and the second housing 12 can be arranged in one piece. In the embodiment shown in Figure 1 or 2, they are arranged separately at the outer sampling port 42 to facilitate the first wall 431 installation.

Please refer to Figures 1-2 and 5-6. The switch assembly 5 includes a driving unit 51 that drives the elastic wall close to the second wall 432, and a control unit communicatively connected with the driving unit 51. 52. The control unit 52 is used to control the working state of the switch assembly 5 .

The driving unit 51 includes a micromotor 511 that is communicatively connected to the control unit 52, and a top block 513 that is threadedly connected to the rotor 512 of the micromotor 511; when the rotor 512 rotates, it is transformed into the top block through threaded fit. The linear movement of block 513 exerts force on the elastic wall.

The load and displacement generated by the micromotor 511 are small, which reduces the performance requirements of the micromotor, making the entire system structurally complete, compact, simple, and easy to seal and sample. The micromotor 511 includes but is not limited to an ordinary motor or a stepper motor, and can actively open or close the sampling channel 43 .

In an embodiment in which the top block 513 is not connected to the elastic wall, when the rotor 512 rotates forward, the top block 513 is threaded along the length direction of the sampling capsule 100 and toward the The second wall 432 moves in one direction and pushes the elastic wall to fit against the second wall 432 to close the sampling channel 43; when the rotor 512 rotates reversely, the top block 513 moves away from the second wall 432. When the second wall 432 moves in one direction, the elastic wall returns to its original shape under its own elastic force, leaves the second wall 432, and opens the sampling channel 43 to implement sampling.

Those skilled in the art can understand that by controlling the displacement of the top block 513 along the length direction, the conduction amount of the sampling channel 43 can be controlled, thereby controlling the flow rate of sampling; The displacement controls the duration of sampling, thereby enabling precise control of the injection volume.

In the embodiment where the top block 513 is connected to the elastic wall, the only difference between the two is not connected is that when the rotor 512 rotates forward, the top block 513 is threaded along the The sampling capsule 100 moves in the length direction and toward the second wall 432, and pushes the elastic wall to fit against the second wall 432, closing the sampling channel 43; when the rotor 512 rotates reversely , the top block 513 moves away from the second wall 432, and at the same time actively pulls the elastic wall away from the second wall 432, opening the sampling channel 43; therefore, the distance between the elastic wall and the second wall is 432 and the opening time of the sampling channel 43 are statistically more accurate, so that the injection volume can be controlled more accurately.

Furthermore, the switch assembly 5 further includes a slide rail 514 provided on the inner wall of the housing 1 to limit the linear movement of the top block 513 to prevent the top block 513 from rotating with the rotor 512 .

In another type of embodiment, please refer to FIGS. 7 and 8 . The difference from the embodiment shown in FIGS. 1 to 6 mainly lies in the difference of the driving unit 51 . The same numbers in the figures represent the same structure.

Specifically, the driving unit 51 includes a moving block 51a that drives the elastic wall close to or away from the second wall 432, and a driving mechanism that drives the moving block 51a to move. The driving mechanism includes one end connected to the moving block 51a and the other end connected to a fixed The shape memory alloy 51b connected to the block 51d and the temperature control element 51c are communicatively connected with the control unit 52 to control the temperature of the shape memory alloy 51b. The control unit 52 is further used to control the working state of the switch assembly 5 by controlling the temperature control element 51c.

Those skilled in the art can understand that the position of the fixed block 51d in the sampling capsule is fixed, and the position of the elastic wall is adjusted by the movement of the moving block 51a; the moving block 51a is connected to the elastic wall Or both can be installed separately, and the way in which the moving block 51a exerts force on the elastic wall to move is the same as the way in which the top block 513 applies force on the elastic wall to move, which will not be described again here.

The moving block 51a and the fixed block 51d used in conjunction with each other are called a set of moving blocks 51a and fixed blocks 51d. A set of moving blocks 51a and fixed blocks 51d corresponds to one shape memory alloy 51b; or multiple sets of moving blocks 51a and fixed blocks 51d correspond to one shape memory alloy 51b, that is, one shape memory alloy 51b can drive multiple sets of moving blocks at the same time. 51a and fixed block 51d; of course, multiple moving blocks 51a can also correspond to one fixed block 51d, or one moving block 51a can correspond to multiple fixed blocks 51d, and the number and placement position of the shape memory alloy 51b can be determined according to the moving blocks. The arrangement of 51a has been adjusted accordingly.

One shape memory alloy 51b corresponds to one temperature control element 51c, or multiple shape memory alloys 51b correspond to one temperature control element 51c, that is, one temperature control element 51c controls the temperature changes of multiple shape memory alloys 51b. The number and arrangement of the temperature control elements 51c are adaptively adjusted according to the arrangement of the plurality of shape memory alloys 51b.

The two ends of the shape memory alloy 51b are respectively connected to the moving block 51a and the fixed block 51d in a manner including but not limited to: the shape memory alloy 51b is provided between the moving block 51a and the fixed block 51d, and the shape memory alloy 51b is Both ends are connected to opposite sides of the moving block 51a and the fixed block 51d respectively. Or the shape memory alloy 51b is provided on the same side of the moving block 51a and the fixed block 51d, and the two ends of the shape memory alloy 51b are respectively opposite to the side of the moving block 51a and the fixed block 51d facing the shape memory alloy 51b. connect. Or the shape memory alloy 51b is provided on the same side of the moving block 51a and the fixed block 51d, and the two ends of the shape memory alloy 51b are respectively connected to the opposite sides of the moving block 51a and the fixed block 51d through connecting pieces. Therefore, when the length of the shape memory alloy 51b changes, the moving block 51a can be driven to move closer to or away from the fixed block 51d.

When the temperature is lower than the shape recovery threshold, the shape memory alloy 51b has the first shape state, and the distance between the moving block 51a and the fixed block 51d is the first distance; when the temperature is higher than the shape recovery threshold, the shape memory alloy 51b has a second shape state, the distance between the moving block 51a and the fixed block 51d is the second distance, the first distance is smaller than or larger than the second distance; and the larger of the first distance and the second distance is configured as , the moving block 51a exerts force on the elastic wall to make the elastic wall adhere to the second wall 432 and close the sampling channel 43; the smaller of the first distance and the second distance is configured as, The elastic wall is driven by the moving block 51a or under its own elastic force and is separated from the second wall 432 to open the sampling channel 43.

In one type of embodiment, the temperature control element 51c is a heating element, and the first distance is greater than the second distance. When the temperature is lower than the shape recovery threshold, the shape memory alloy 51b is in an elongated first shape state, the moving block 51a is away from the fixed block 51d, and the moving block 51a exerts force on the elastic wall to make it fit. On the second wall 432, the sampling channel 43 is in a closed state; when the heating element is turned on to heat the shape memory alloy 51b, so that the temperature of the shape memory alloy 51b rises above the shape recovery threshold, The shape memory alloy 51b returns to the compressed, bent, or wavy second shape state, and drives the moving block 51a to move toward the fixed block 51d. The distance between the two is reduced, and the elastic wall moves in the moving block 51a. It is separated from the second wall 432 under the driving force or its own elastic force, and the sampling channel 43 is opened to realize sample injection; and when the heating element is turned off, the temperature of the shape memory alloy 51b drops to the shape recovery threshold temperature. After that, due to the two-way effect of the shape memory alloy 51b, the shape memory alloy 51b returns to the first shape state, driving the moving block 51a to move away from the fixed block 51d, and at the same time pushing the elastic wall to fit the On the second wall 432, the sampling channel 43 is closed to seal the sample.

In another type of embodiment, the temperature control element 51c is a cooling element, and the first distance is smaller than the second distance. When the temperature is higher than the shape recovery threshold, the shape memory alloy 51b is in an elongated second shape state, the moving block 51a is away from the fixed block 51d, and the moving block 51a exerts force on the elastic wall to make it fit. On the second wall 432, the sampling channel 43 is in a closed state; when the cooling element is turned on to cool down the shape memory alloy 51b, so that the temperature of the shape memory alloy 51b drops below the shape recovery threshold, The shape memory alloy 51b returns to the compressed, bent, or wavy first shape state, and drives the moving block 51a to move toward the fixed block 51d. The distance between the two is reduced, and the elastic wall moves in the moving block 51a. It is separated from the second wall 432 under the driving force or its own elastic force, and the sampling channel 43 is opened to realize sample injection; and when the cooling element is closed, the temperature of the shape memory alloy 51b rises to the shape recovery threshold. After the temperature is above the temperature, due to the two-way effect of the shape memory alloy 51b, the shape memory alloy 51b returns to the second shape state, driving the moving block 51a to move away from the fixed block 51d, and at the same time pushing the elastic wall to fit On the second wall 432, the sampling channel 43 is closed to seal the sample.

Further, the switch assembly 5 further includes an auxiliary block 56 disposed on the inner wall of the housing 1 to limit the linear movement of the moving block 51a to prevent the moving block 51a from being displaced. At the same time, the auxiliary block 56 can also play a role in assisting in the installation of other structural components.

Not limited to the embodiment shown in FIGS. 7 and 8 , the driving unit 51 with the shape memory alloy 51b is also suitable for the sampling channel 43 shown in FIGS. 5 and 6 .

In addition, please refer to FIGS. 1 to 2 and 5 to 8 . The switch assembly 5 also includes a sensor 53 , a storage module 54 , etc. that are communicatively connected to the control unit 52 . The sensor 53 is used to collect physiological parameters and/or image information in the digestive tract. The information collected can be used for system positioning to determine the location of the sampling capsule 100 and whether sampling needs to be performed. The storage module 54 is used to store normal physiological parameters and/or image information of different parts of the digestive tract, and physiological parameters and/or image information of possible lesions. The control unit 52 can store the information obtained by the sensor 53 Compare with stored physiological parameters and/or image information to determine the location of the sampling capsule 100 and whether sampling needs to be performed.

The sensor 53 is at least one of an image sensor, a pH sensor, or an ultrasonic sensor; when there are multiple sensors 53 , the judgment is more accurate.

Specifically, when the sensor 53 includes an image sensor, part of the housing 1 is transparent, and the image sensor can obtain an external image of the digestive tract.

Or when the sensor 53 includes an ultrasonic sensor, the physiological parameters of the digestive tract are obtained through ultrasonic waves. At this time, the housing 1 serves as an acoustic medium between the ultrasonic sensor and the object to be imaged, such as the inner wall of the digestive tract, and its acoustic performance enables it to Provides good acoustic coupling effect and improves ultrasound imaging quality.

Or when the sensor 53 includes a pH sensor, the housing 1 has a window through which the pH sensor contacts the digestive tract fluid. Those skilled in the art can understand that the window is configured such that the digestive tract fluid can only come into contact with the detection site of the pH sensor and cannot come into contact with other components.

Further, the sampling capsule 100 also includes a wireless transmission module 55 for communicating with an external processing terminal. The information collected by the sensor 53 is transmitted to the external processing terminal through the wireless transmission module 55. The external processing terminal processes The data information can more accurately determine the location of the sampling capsule 100 and whether sampling needs to be performed; or the external processing terminal updates the information of the memory and controller through the wireless transmission module 55. In addition, the information obtained through the sensor 53 will also be displayed on the display instrument in real time for the doctor to view, and the doctor can actively send sampling instructions for sampling.

In this embodiment, the storage module 54 is also used to store information transmitted from the external processing terminal.

The following will take an embodiment with a wireless transmission module 55 as an example to describe how to assist in controlling the working state of the sampling capsule 100 through each sensor 53 .

When the sensor 53 is an image sensor, the obtained image is transmitted to an external processing terminal through the wireless transmission module 55. The external processing terminal processes the obtained image and identifies the sampling capsule 100 through human eyes and computer vision algorithms. The part of the digestive tract where it is located. In addition, doctors or algorithms can also determine the presence or absence of some lesions through images to determine whether sampling is needed. If sampling is required, the external processing terminal transmits the information that needs sampling to the control unit 52 through the wireless transmission module 55, and the control unit 52 controls the switch component 5 to open the sampling channel 43 to perform sampling. Specifically, when a special image is recognized or other special comprehensive information appears, the sampling requirements are met. The external processing terminal can send prompt information to the doctor to wait for the doctor's confirmation, or directly send the sample to the sampling capsule 100 through the wireless transmission module 55 Send the sampling command to start sampling.

When the sensor 53 is an ultrasonic sensor, the usage process is similar to the above-mentioned image sensor. The only difference is that the image is a B-ultrasound image, which will not be described again.

When the sensor 53 is a pH sensor, the obtained pH value is transmitted to the external processing terminal through the wireless transmission module 55 to process the obtained pH value to determine the position of the sampling capsule 100, thereby deciding whether to perform sampling. . If sampling is required, the external processing terminal transmits the information that needs sampling to the control unit 52 through the wireless transmission module 55, and the control unit 52 controls the switch component 5 to open the sampling channel 43 to perform sampling. Specifically, when a special pH value or special pH value curve fluctuation occurs, the sampling requirements are met. The external processing terminal can send prompt information to the doctor to wait for the doctor's confirmation, or directly send it to the sampling capsule 100 through the wireless transmission module 55 Sampling command to start sampling.

The sampling capsule 100 also includes a battery (not shown) that provides power to each structure of the switch assembly 5 to ensure that the control unit 52, the driving unit 51, the wireless transmission module 55, and the storage Module 54 and the sensor 53 work normally.

The present invention also provides a sampling capsule system, including any one of the above sampling capsules 100 and an external processing terminal communicatively connected to the switch assembly 5 . Specifically, the switch assembly 5 at least includes a control unit 52 that controls the working state of the switch assembly 5 and a wireless transmission module 55 that is communicatively connected to the control unit 52. The external processing terminal communicates with the external processing terminal through the wireless transmission module 55. The control unit 52 is connected through communication to control the working state of the sampling capsule 100; other structures are as described above and will not be described again.

The present invention also provides a control method based on the above-mentioned sampling capsule 100, which includes the following steps: determine whether sampling is required, and if so, the switch component 5 opens the sampling channel 43; after sampling is completed, the switch component 5 closes the sampling channel 43. Sample channel 43. Determining whether sampling is required can be determined by any of the above description methods, and will not be described again here. The switch component 5 can open or close the sampling channel 43 in any of the above ways, which will not be described again here.

To sum up, the sampling capsule 100 of the present application passes through the switch assembly 5. When the sampling capsule 100 reaches the part of the digestive tract to be detected, the sampling channel 43 is opened, and the digestive fluid is sampled through the external sampling port 42. The channel 43 and the inner sampling port 41 enter the sampling pool 3 to implement sampling; after the sampling is completed, the sampling channel 43 is closed to prevent the sample from leaking or being contaminated; and by controlling the opening time of the sampling channel 43 , can accurately control the injection volume. In addition, the opening or closing of the sampling channel 43 is actively controlled by the switch assembly 5 and is not affected by the environment of the digestive tract. It can be used in any part of the digestive tract and has high versatility.

It should be understood that although this specification is described in terms of implementations, not each implementation only contains an independent technical solution. This description of the specification is only for the sake of clarity. Persons skilled in the art should take the specification as a whole and understand each individual solution. The technical solutions in the embodiments can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

The series of detailed descriptions listed above are only specific descriptions of feasible implementations of the present application. They are not intended to limit the protection scope of the present application. Any equivalent implementations or implementations that do not deviate from the technical spirit of the present application or All changes should be included in the protection scope of this application.

Claims (10)

1. A sampling capsule, comprising a shell, a partition wall provided in the shell, and a sampling pool formed by the partition wall and the shell located on the first side of the partition wall; characterized in that, The sampling capsule further includes: an inner sample inlet provided on the partition wall, an outer sample inlet provided on the outer shell located on the second side of the partition wall, connecting the outer sample inlet and the The sampling channel of the inner sampling port and the switch component that opens or closes the sampling channel; Wherein, the wall surrounding the sampling channel includes a first wall and a second wall arranged oppositely, and at least part of the first wall is an elastic wall; the switch assembly exerts force on the elastic wall to adjust the The distance between the elastic wall and the second wall is such that the elastic wall is close to the second wall to close the sampling channel or to open the sampling channel away from the second wall; The switch assembly includes a driving unit that drives the elastic wall close to the second wall and a control unit that is communicatively connected to the driving unit; the driving unit includes a micromotor that is communicatively connected to the control unit and the The rotor of the micromotor is threadedly connected to the top block; when the rotor rotates, the thread fit is converted into linear motion of the top block, thereby exerting force on the elastic wall. 2. The sampling capsule according to claim 1, characterized in that: the top block is not connected to the elastic wall; or the top block is connected to the elastic wall. 3. The sampling capsule according to claim 1, wherein the switch assembly further includes a slide rail disposed on the inner wall of the housing to limit the linear movement of the top block. 4. The sampling capsule according to claim 1, wherein the micromotor is a motor or a stepper motor, and the micromotor is located on the side of the top block facing away from the elastic wall. 5. The sampling capsule according to claim 1, characterized in that: the switch assembly further includes: A sensor that is communicatively connected to the control unit, the sensor is used to collect physiological parameters and/or image information in the digestive tract; the sensor is at least one of an image sensor, a pH sensor, or an ultrasonic sensor; the sensor When an image sensor is included, part of the housing is transparent; when the sensor includes a pH sensor, the housing has a window, and the pH sensor contacts the digestive tract fluid through the window; A storage module communicatively connected to the control unit, the storage module is used to store normal physiological parameters and/or image information of different parts of the digestive tract, and physiological parameters and/or image information of possible lesions; A wireless transmission module used to communicate with external processing terminals. 6. The sampling capsule according to any one of claims 1 to 5, characterized in that: the partition wall and the shell located on the first side of the partition wall are integrally arranged; or the partition wall and the shell located on the first side of the partition wall are integrally arranged; The shell on the first side of the partition wall is arranged separately, and the sealing performance of the connection between the two should ensure that the sampling pool can maintain its required vacuum degree of -90kPa ~ -80kPa. 7. The sampling capsule according to any one of claims 1 to 5, characterized in that: the second wall is provided close to the partition wall, and the first wall is provided on the sampling channel away from the partition wall. On one side, the outer sample inlet is disposed between the first wall and the second wall; Or, the partition wall constitutes the second wall, the first wall is an elastic wall spaced apart from the partition wall, and the outer sample inlet is provided between the partition wall and the elastic wall, The sampling channel is formed between the elastic wall and the partition wall; Or, both the first wall and the second wall are elastic walls, and the first wall and the second wall are integrally provided, and the sampling channel is a multi-pass tube, and part of the tube opening is connected to the inner wall. The injection port is connected, and some other pipe ports are connected to the external injection port. 8. A sampling capsule system, comprising the sampling capsule according to any one of claims 1 to 7, and an external processing terminal communicatively connected to the switch assembly. 9. A control method based on the sampling capsule according to any one of claims 1 to 7, characterized in that it includes the following steps: determining whether sampling is required, and if so, the switch component opens the sampling channel; after sampling is completed , the switch component closes the sampling channel. 10. The control method according to claim 9, characterized in that: the switch assembly further includes: a sensor communicatively connected to the control unit, the sensor is used to collect physiological parameters and/or image information in the digestive tract; A storage module that is communicatively connected to the control unit. The storage module is used to store normal physiological parameters and/or image information of different parts of the digestive tract, and physiological parameters and/or image information of possible lesions; used to communicate with the outside world. A wireless transmission module that handles terminal communication connections; among which, The sensor is an image sensor, and part of the housing is transparent; an external image of the digestive tract is obtained through the image sensor, and the wireless transmission module transmits the obtained image to an external processing terminal, and the external processing terminal processes the obtained image. Processing, identifying the part of the digestive tract where the sampling capsule is located, whether there is a lesion, and deciding whether to sample based on the information about the part of the digestive tract and whether there is a lesion; Or, the sensor is a pH sensor, and the housing has a window, and the pH sensor contacts the digestive tract liquid through the window; the pH value of the digestive juice of the digestive tract is obtained through the pH sensor, and the obtained pH value is passed through the The wireless transmission module transmits it to the external processing terminal to process the obtained pH value to determine the position of the sampling capsule, and decide whether to sample according to the location of the digestive tract; Or, the sensor is an ultrasonic sensor; the external digestive tract image is obtained through the ultrasonic sensor, and the wireless transmission module transmits the obtained image to an external processing terminal, and the external processing terminal processes the obtained image to identify the sample The part of the digestive tract where the capsule is located and whether there is a lesion, and whether to take a sample is decided based on the information about the part of the digestive tract and whether there is a lesion.