CN117158964B - Sampling assembly, blood quantitative sampling device and sampling method - Google Patents
Sampling assembly, blood quantitative sampling device and sampling method Download PDFInfo
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- CN117158964B CN117158964B CN202311445394.7A CN202311445394A CN117158964B CN 117158964 B CN117158964 B CN 117158964B CN 202311445394 A CN202311445394 A CN 202311445394A CN 117158964 B CN117158964 B CN 117158964B
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- 239000008280 blood Substances 0.000 title claims abstract description 87
- 210000004369 blood Anatomy 0.000 title claims abstract description 87
- 238000000034 method Methods 0.000 title description 21
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 86
- 238000001514 detection method Methods 0.000 claims abstract description 26
- 230000000149 penetrating effect Effects 0.000 claims abstract description 4
- 238000010241 blood sampling Methods 0.000 claims description 25
- 230000003014 reinforcing effect Effects 0.000 claims description 16
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- 230000009471 action Effects 0.000 claims description 9
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- 239000007788 liquid Substances 0.000 description 11
- 238000007789 sealing Methods 0.000 description 10
- 239000003814 drug Substances 0.000 description 9
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
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- 208000015181 infectious disease Diseases 0.000 description 3
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- 208000027418 Wounds and injury Diseases 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 238000002405 diagnostic procedure Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
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- 230000006978 adaptation Effects 0.000 description 1
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Abstract
The invention discloses a sampling assembly, which comprises a sampling tube and a sampling shell, wherein the sampling shell is provided with a sampling space for accommodating a reagent strip, the sampling tube is provided with a first end, a second end and a sampling cavity, the sampling cavity penetrates through the first end and the second end, the first end is provided with a first connector, and the second end is provided with a second connector; the second end is connected to the sampling space through the sampling shell in a penetrating way. The sampling assembly of the invention can directly connect the syringe with the catheter and can also realize the rapid detection of quantitative blood samples.
Description
Technical Field
The invention relates to the technical field of sampling instruments, in particular to a sampling assembly, a blood quantitative sampling device and a sampling method.
Background
With the improvement of medical technology, diagnostic test papers capable of analyzing human health information with only a small amount of blood have begun to be widely used. Particularly, for hospitalized patients, regular blood sampling is needed for health monitoring, but regular blood sampling can cause a plurality of wounds on the body of the patient, and although catheters, indwelling needles and injection needles implanted into the human body solve the problem of excessive wounds, the catheters, indwelling needles and injection needles implanted into the human body simultaneously have tube sealing liquid or medicine residues, and the conventional microsampling equipment cannot directly connect the syringe with the catheters, so before the syringe is used for extracting blood samples, in order to avoid the influence of the tube sealing liquid or the medicine residues on the detection result, a blood discarding method or a push-pull mixing method is usually adopted, 5-25ml of blood is required to be sucked by the syringe for discarding by adopting the blood discarding method, the blood discarding amount is large, and anemia easily occurs to the patient if frequent operation is performed. The syringe is required to be taken down after the sucked and pushed back blood is mixed by adopting a push-pull mixing method and then connected with a blood taking device or a new syringe, and the syringe is connected for a plurality of times, so that the infection risk is increased.
Disclosure of Invention
In order to overcome the shortcomings of the prior art, it is an object of the present invention to provide a sampling assembly that enables direct connection of a syringe to a catheter and also enables rapid detection of a quantitative blood sample.
One of the purposes of the invention is realized by adopting the following technical scheme:
The sampling assembly comprises a sampling tube and a sampling shell, wherein the sampling shell is provided with a sampling space for accommodating a reagent strip, the sampling tube is provided with a first end, a second end and a sampling cavity, the sampling cavity penetrates through the first end and the second end, the first end is provided with a first connector, and the second end is provided with a second connector; the second end is connected to the sampling space through the sampling shell in a penetrating way.
Further, the sampling cavity extends along a first direction, the sampling space is provided with a first opening and a second opening, the first opening penetrates through the second opening along a second direction, and the second direction is perpendicular to the first direction.
Further, the sampling shell comprises a connecting section, a first extending section and a second extending section, wherein the connecting section is vertically arranged on the outer peripheral surface of the sampling tube, the first extending section and the second extending section are respectively extended from two opposite sides of the connecting section towards the direction away from the first end, and the first extending section and the second extending section are arranged at intervals and form the sampling space.
Further, a first buckle is arranged on the end face, close to the second extension section, of the first extension section, a second buckle is arranged on the end face, close to the first extension section, of the second extension section, and the first buckle and the second buckle are arranged oppositely; the first buckle and the second buckle are used for abutting with the bottom end of the reagent strip after the reagent strip is clamped in the sampling space, so that the reagent strip is limited to be separated from the sampling space from the first direction.
Further, the first extension section is close to the terminal surface of second extension section is equipped with first enhancement section, the second extension section is close to the terminal surface of first extension section is equipped with the second enhancement section, first enhancement section and second enhancement section be used for after reagent strip joint in sample space with the top butt of reagent strip.
Further, the sampling cavity comprises a first cavity and a second cavity, wherein the inner diameter of the first cavity is larger than that of the second cavity.
Further, a bench stage is arranged at the bottom end of the first cavity, and the bench stage extends from the inner wall of the sampling cavity towards the central axis direction of the sampling cavity and encloses to form the second cavity.
The second object of the present invention is to provide a blood quantitative sampling device, which integrates the functions of blood sampling and quantitative sampling detection, and realizes the rapid detection of quantitative blood samples.
The second purpose of the invention is realized by adopting the following technical scheme:
A blood quantitative sampling device comprises a syringe, the sampling assembly and a catheter, wherein one end of the syringe is detachably connected with the first connector, and one end of the catheter is detachably connected with the second connector; the reagent strip is provided with a sample inlet, and the sampling space is used for guiding the reagent strip to be introduced after the second connector is detached from the catheter, so that the sampling cavity is communicated with the sample inlet.
Further, the first connector is a first luer connector, the syringe comprises a push-pull rod and a barrel, one end of the push-pull rod is slidably arranged in the barrel, one end of the barrel, far away from the push-pull rod, is provided with a second luer connector, and the first luer connector is in locking connection with the second luer connector so that the sampling cavity is communicated with the barrel.
Further, the second connector is a third luer connector, the first end of the catheter is provided with a fourth luer connector, and the third luer connector is in locking connection with the fourth luer connector.
The third object of the present invention is to provide a sampling method, which can simplify the steps of blood sampling and quantitative sampling detection by adopting the sampling method, and realize the rapid detection of quantitative blood samples.
The third purpose of the invention is realized by adopting the following technical scheme:
a method for quantitatively sampling blood using the above-mentioned quantitative blood sampling device, comprising the steps of:
S1, pulling the push-pull rod to suck part of blood to a barrel of the syringe through the catheter and the sampling cavity;
S2, pressing the push-pull rod to push part of blood of the cylinder back into the catheter;
s3, repeating the steps S1 and S2 for at least 2 cycles;
s4, removing the syringe and the sampling assembly from the catheter together;
S5, introducing the reagent strip into a sampling space of the sampling assembly along a first direction or a second direction;
s6, horizontally placing the reagent strip and taking down the injector, so that blood in the sampling cavity drops to a sample inlet of the reagent strip under the action of gravity.
Compared with the prior art, the invention has the beneficial effects that:
1. The sampling component of the application is used for respectively connecting two ends of the sampling component with the injector and the catheter when blood is sampled, and can realize quantitative sampling from the sampling cavity by keeping the connection of the injector, the sampling component and the catheter for sucking and injecting, when the device is used for quantitative blood sample detection, only the blood to be detected is injected into the sampling cavity, then the reagent strip is led into the sampling space, the quantitative blood sample is dropped into the reagent strip by the gravity of the blood in the sampling cavity, and the rapid detection of the quantitative blood sample can be realized without being sent to a laboratory.
2. The quantitative blood sampling device comprises the injector and the catheter which are connected through the sampling component, so that the steps from blood sampling to quantitative blood sampling are simplified, the reagent strip can be directly led into the sampling space after the injector and the sampling component are taken off from the catheter, and the first direction is placed to be parallel to the vertical surface, so that the blood in the sampling cavity drops into the reagent strip under the action of gravity, and the quantitative blood sample can be rapidly detected without other tools such as microsampling equipment and the like.
3. According to the sampling method, by using the blood quantitative sampling device, when blood is sampled, the connection of the injector, the sampling assembly and the catheter is kept for at least two times of circulating sucking and pushing back operations, so that tube sealing liquid or residual medicine in the catheter can be eliminated, waste blood and replacement of the injector are not needed, and the volume of the sampling cavity is quantitative, and the sample is not needed to be sent to a laboratory for sampling by using micro quantitative sampling equipment.
Drawings
FIG. 1 is a schematic diagram of a sampling assembly according to the present invention;
FIG. 2 is a schematic diagram of a sampling assembly according to the present invention in semi-section;
FIG. 3 is a schematic view of a blood sampling mode of the quantitative blood sampling device of the present invention;
FIG. 4 is a schematic diagram of a sample detection mode according to the present invention;
FIG. 5 is a schematic structural view of the reagent strip of the present invention.
In the figure:
1. A sampling assembly; 10. a sampling cavity; 100 sampling spaces; 101. a first cavity; 102. a second cavity; 11. a sampling tube; 12. a sampling housing; 120. a connection section; 121. a first extension; 122. a second extension; 123. a first reinforcing section; 124. a second reinforcing section; 1211. a first buckle; 1221. a second buckle;
2. A syringe; 21. a cylinder; 22. a push-pull rod;
3. A conduit;
41. a first luer fitting; 42. a second luer fitting; 43. a third luer fitting; 44. a fourth luer fitting;
5. A reagent strip; 50. and a sample inlet.
Detailed Description
For a better understanding and implementation, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention.
In the description of the present invention, it should be noted that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, only for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the apparatus or elements to be referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present invention.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
As shown in fig. 1-2, the application discloses a sampling assembly 1, which comprises a sampling tube 11 and a sampling housing 12, wherein the sampling housing 12 is provided with a sampling space 100 for accommodating a reagent strip 5, the sampling tube 11 is provided with a first end, a second end and a sampling cavity 10, the sampling cavity 10 penetrates through the first end and the second end, the first end is provided with a first connector, the second end is provided with a second connector, and the second end is connected to the sampling space 100 through the sampling housing 12 in a penetrating way.
The sampling cavity 10 extends along a first direction (X direction shown in fig. 1), the sampling space 100 has a first opening and a second opening, the first opening penetrates to the second opening along a second direction (Y direction shown in fig. 1), and the second direction is perpendicular to the first direction.
Thus, when the reagent strip 5 is introduced into the sampling space 100, the reagent strip 5 is pushed along the second direction to be guided to the sampling space 100, so that the blood sample in the sampling cavity 10 can quantitatively fall onto the reagent strip 5 along the first direction, and quantitative sampling detection is realized.
Specifically, the sampling housing 12 includes a connection section 120, a first extension section 121 and a second extension section 122, the connection section 120 is vertically disposed on an outer peripheral surface of the sampling tube 11, the first extension section 121 and the second extension section 122 extend from opposite sides of the connection section 120 toward a direction away from the first end, the first extension section 121 and the second extension section 122 are disposed at intervals and form the sampling space 100, the sampling space 100 has a first opening and a second opening, and the first opening penetrates to the second opening along the second direction.
On the basis of the above structure, when the reagent strip 5 is introduced into the sampling space 100, one end of the reagent strip 5 sequentially passes through the first opening and the second opening along the second direction, and two opposite sides of the reagent strip 5 respectively attach to and slide with the first extension section 121 and the second extension section 122 until the sampling cavity 10 is aligned with a proper position of the reagent strip 5.
The embodiment is described with two usage modes of sampling and sampling detection of the sampling assembly 1:
In the blood sampling mode, as shown in fig. 3, the syringe 2 is connected to the first connector of the sampling tube 11, the catheter 3 inserted into the blood vessel is connected to the second connector of the sampling tube 11, and after the connection is completed, suction is started by using the syringe 2, and blood flows from the catheter 3 to the filling catheter 3, the sampling chamber 10, and the syringe 2, thereby completing blood sampling.
The existing blood collection tools are usually implemented by using a syringe or a blood drawing needle, and due to the tube sealing liquid or medicine residue in the catheter, the method of taking blood by using the syringe through the catheter is generally carried out by two methods: firstly, the blood discarding method needs to suck partial blood discard by using a syringe, and the blood discarding amount is large. Secondly, the push-pull mixing method is used for sucking blood to be mixed with the tube sealing liquid or the residual medicine and then replacing a new syringe, so that the connection is carried out for a plurality of times, and the infection risk is easily increased.
In the blood sampling mode of this embodiment, only the syringe 2, the sampling assembly 1 and the intravascular catheter 3 are required to be connected in sequence, and under the condition of not disconnecting, after the syringe 2 is used for sucking blood to the syringe 2, part of the blood is pushed back to the catheter 3 by the syringe 2, so that after the tube sealing liquid or the residual medicine is eliminated, quantitative blood can be directly obtained in the sampling cavity 10.
Compared with the existing blood collection tool, the blood collection device of the embodiment is connected between the syringe 2 and the catheter 3 by using the sampling assembly 1, so that the step of disconnecting the syringe 2 from the catheter 3 to replace the syringe 2 is omitted, the infection risk caused by multiple connection is avoided, and the sucked blood can be pushed back to the sampling cavity 10 and the catheter 3 completely without discarding the blood.
The sample detection mode is shown in fig. 4, and has two methods of use:
Based on the structure of the blood sampling mode, the syringe 2 and the sampling assembly 1 are taken down together from the catheter 3, then the reagent strip 5 is guided into the sampling space 100 from the first direction or the second direction, after the reagent strip 5 is guided into the sampling space 100, the reagent strip 5 is horizontally placed until the reagent strip extends along the horizontal plane, namely, the second direction is parallel to the horizontal plane, the first direction is parallel to the vertical plane, then the syringe 2 is taken down from the sampling assembly 1, and at the moment, blood in the sampling assembly 1 drops into the reagent strip 5 corresponding to the sampling space 100 under the action of gravity, so that quantitative sampling detection is realized.
The other method is to inject other blood sampling devices into the sampling cavity 10 to obtain blood to be tested, then directly introduce the reagent strip 5 into the sampling space 100, and make the blood to be tested in the sampling cavity 10 drop a quantitative blood sample into the reagent strip 5 under the action of gravity after the reagent strip 5 is laid flat, so that quantitative sampling detection can be realized.
Compared with the existing microsampling device, the existing microsampling device cannot be directly connected with the catheter 3 (infusion catheter, indwelling needle, injection needle and the like) inserted into a blood vessel, so that blood to be measured cannot be directly extracted and quantitatively sampled, and the blood to be measured cannot be directly sampled, and the blood to be measured cannot be quantitatively sampled.
Thus, with the sampling assembly 1 of the present application, on the one hand, for taking blood, quantitative sampling can be achieved from the sampling chamber 10 by holding the syringe 2, the sampling assembly 1 and the catheter 3 connected for aspiration and injection, and on the other hand, for detecting quantitative blood samples, only the blood to be detected needs to be injected into the sampling chamber 10, then the reagent strip 5 is introduced into the sampling space 100, and quantitative blood samples are dropped into the reagent strip 5 by the gravity of the blood itself in the sampling chamber 10, and rapid detection of quantitative blood samples can be achieved without being sent to a laboratory.
It should be noted that, in order to adapt to various test tools in the prior art, such as a reagent card, a diagnostic test paper, etc., in other embodiments, the structure of the sampling housing 12 may be reasonably designed according to the structure of the test tool, so long as the finally formed sampling assembly 1 can connect the syringe 2 and the catheter 3, and after the sampling assembly 1 is removed, the test tool may be directly introduced into the sampling space 100 of the sampling housing 12 for quantitative detection.
As shown in fig. 2, further, a first buckle 1211 is disposed on an end surface of the first extension section 121 near the second extension section 122, a second buckle 1221 is disposed on an end surface of the second extension section 122 near the first extension section 121, the first buckle 1211 and the second buckle 1221 are disposed opposite to each other, and the first buckle 1211 and the second buckle 1221 abut against a bottom end of the reagent strip 5 after the reagent strip 5 is clamped in the sampling space 100, so as to limit the reagent strip 5 from being separated from the sampling space 100 from the first direction.
Based on the above structure, when the reagent strip 5 is clamped in the sampling space 100, the reagent strip may be fastened by the first fastener 1211 and the second fastener 1221 along the first direction and then fixed in the sampling space 100, or may extend into the first opening and extend out of the second opening along the second direction, so that one end of the reagent strip 5 extends out of the first opening, the other end extends out of the second opening, and after the reagent strip 5 is introduced into the sampling space 100, the top end of the reagent strip 5 abuts against the sampling tube 11, and the bottom ends abut against the first fastener 1211 and the second fastener 1221, thereby limiting the reagent strip 5 from being separated from the sampling space 100 along the first direction.
In this regard, the first catch 1211 and the second catch 1221 of the present embodiment may be preferably of a convex structure having circular arc surfaces in both the first direction and the second direction, so that the circular arc surfaces and the surface of the reagent strip 5 may be slidably engaged to perform a guiding function when the reagent strip 5 is introduced, thereby realizing that the reagent strip 5 may be optionally introduced into the sampling space 100 from both the first direction and the second direction.
Of course, in other embodiments, the first catch 1211 and the second catch 1221 may be elastic snap-tab structures, and the specific deformation direction may be designed according to the direction of introduction of the selected reagent strip 5, so long as the deformation can be achieved when the reagent strip 5 is introduced, until the snap-tab returns to its original shape and fixes the reagent strip 5 in the sampling space 100 after the reagent strip 5 is introduced into the proper position.
Further, in order to make the introduction of the reagent strip 5 into the sampling space 100 smoother, the end surface of the first extension section 121 close to the second extension section 122 is provided with a first reinforcing section 123, the end surface of the second extension section 122 close to the first extension section 121 is provided with a second reinforcing section 124, and the first reinforcing section 123 and the second reinforcing section 124 are used for abutting against the top end of the reagent strip after the reagent strip 5 is clamped in the sampling space 100. It will be appreciated that the first stiffening segment 123 is spaced from the second stiffening segment 124 and that a space is reserved for the connection of the second connector to the conduit 3.
In the description of the introduction of the reagent strip 5 into the sampling space 100 along the second direction, on the basis of the above structure, the reagent strip 5 extends from the first opening and penetrates through the second opening, on the one hand, in the process, the bottom ends of the first reinforcing section 123 and the second reinforcing section 124 are respectively abutted against the corresponding two positions of the top end of the reagent strip 5, so that the reagent strip 5 can be introduced into the sampling space 100 in a stable state, and the first reinforcing section 123 and the second reinforcing section 124 can be matched with the first buckle 1211 and the second buckle 1221 to further fix the reagent strip 5 in the first direction, on the other hand, the thickness of the extending sections is increased, and the strength and the rigidity of the first extending section 121 and the second extending section 122 can be improved, thereby enhancing the structural strength of the sampling housing 12.
As shown in fig. 2, specifically, the sampling cavity 10 includes a first cavity 101 and a second cavity 102, where the inner diameter of the first cavity 101 is larger than the inner diameter of the second cavity 102, specifically, the sampling cavity 10 has a structure that a stage 103 is disposed at the bottom end of the first cavity 101, and the stage 103 extends from the inner wall of the sampling cavity 10 toward the central axis direction of the sampling cavity 10 and encloses to form the second cavity 102, so that, under the structure of the stage 103, the inner diameter of the first cavity 101 is larger than the inner diameter of the second cavity 102, and of course, in other embodiments, a cambered surface or inclined surface connection can be adopted between the inner wall of the first cavity 101 and the inner wall of the second cavity 102, so long as the connection of the syringe 2 to the sampling cavity 11 can be prevented from being too deep, so as to avoid affecting the capacity of the sampling cavity 10 in the use.
As shown in fig. 3, the present application further discloses a quantitative blood sampling device, which comprises a syringe 2, the above sampling assembly 1 and a catheter 3, wherein one end of the syringe 2 is detachably connected with the first connector, one end of the catheter 3 is detachably connected with the second connector, the reagent strip 5 has a sample inlet 50, and the sampling space 100 is used for guiding the introduction of the reagent strip after the second connector is detached from the catheter 3, so that the sampling cavity 10 can be communicated with the sample inlet 50.
On the basis of the structure, the syringe 2 is connected with the first connector of the sampling assembly 1, the intravascular catheter 3 is connected with the second connector of the sampling assembly 1, a proper amount of blood is sucked into the catheter 3, the sampling cavity 10 and the syringe 2 through the syringe 2, and then the blood of the syringe 2 is pushed back to the sampling cavity 10 and the catheter 3, so that the quantitative collection of the blood into the sampling cavity 10 is realized.
In the blood sampling device of the present embodiment, the syringe 2 is connected to the catheter 3 via the sampling unit 1, and the syringe is connected to the catheter 3 without sucking blood, so that the catheter-sealing liquid or the drug in the catheter is not required to remain in the syringe, and then the syringe is detached from the catheter to be replaced with a new syringe, and the syringe 2, the sampling unit 1 and the catheter 3 are connected to each other, so that the blood suitable for detection can be collected quantitatively into the sampling chamber 10 by sucking and pushing back the syringe 2.
In the process of sampling and detecting, the syringe 2 and the sampling assembly 1 of the quantitative blood sampling device of the present embodiment can be taken down together from the catheter 3, the reagent strip 5 is introduced into the sampling space 100 of the sampling housing 12, the reagent strip 5 is laid flat, and then the syringe 2 is taken down from the sampling tube 11, so that the quantitative blood sample in the sampling cavity 10 drops into the reagent strip 5 under the action of gravity, and the rapid detection of the quantitative blood sample on site is realized.
Compared with the existing blood sampling and quantitative detection device, the blood quantitative sampling device of the embodiment integrates the functions of blood sampling and quantitative sampling detection, not only simplifies the steps from blood sampling to quantitative blood sampling, but also can directly guide the reagent strip 5 into the sampling space 100 after the syringe 2 and the sampling assembly 1 are taken down from the catheter 3, and place the first direction in parallel with the vertical surface, so that the blood in the sampling cavity 10 drops into the reagent strip 5 under the action of gravity, and quantitative blood sample rapid detection can be realized without using other tools such as microsampling equipment and the like, and the operation is simple.
It should be noted that, in other embodiments, the syringe 2 may be a structure having a liquid transfer function in the prior art, such as a liquid transfer device.
Specifically, the first connector is a first luer connector 41, the syringe 2 includes a push-pull rod 22 and a barrel 21, one end of the push-pull rod 22 is slidably disposed in the barrel 21, one end of the barrel 21 far away from the push-pull rod 22 is provided with a second luer connector 42, and the first luer connector 41 is in locking connection with the second luer connector 42 so that the sampling cavity 10 can be communicated with the barrel 21. The second connector is a third luer connector 43, one end of the catheter 3 is provided with a fourth luer connector 44, and the third luer connector 43 and the fourth luer connector 44 are in locking connection so that the sampling cavity 10 can be communicated with the catheter 3.
The syringe 2 and the sampling tube 11 and the catheter 3 of the present embodiment are connected by luer connectors, and when the connection is broken, the luer connectors can prevent blood from overflowing, and have good sealing property.
The first luer connector 41 and the second luer connector 42 may be a male luer connector and a female luer connector in the prior art, and the third luer connector 43 and the fourth luer connector 44 may be a male luer connector and a female luer connector, respectively.
The embodiment also provides a blood quantitative sampling method using the blood quantitative sampling device, which comprises the following steps:
S1: firstly, connecting two ends of a sampling tube 11 with a cylinder 21 and an intravascular catheter 3 respectively, and sucking a proper amount of blood into the cylinder 21 through the catheter 3 and a sampling cavity 10 by a pull push-pull rod 22;
S2: pressing the push-pull rod 22 pushes part of the blood in the cylinder 21 back to the catheter 3 so that the sucked blood is mixed with the pushed back blood;
s3: repeating the steps S1 and S2 for at least 2 cycles until the blood in the cylinder 21 is completely pushed back into the sampling cavity 10 and the catheter 3, so as to eliminate the tube sealing liquid or the medicine residue in the catheter 3, thereby completing the quantitative collection of the blood in the sampling cavity 10;
S4: the syringe 2 and sampling assembly 1 are then removed from the catheter 3 by maintaining the barrel 21 in connection with the sampling assembly 1;
s5: introducing the reagent strip 5 into the sampling space 100 along the first direction or the second direction, so that the first reinforcing section 123 and the second reinforcing section 124 are abutted with the top end of the reagent strip 5, the first buckle 1211 and the second buckle 1221 are abutted with the bottom end of the reagent strip 5, and the two sides of the reagent strip 5 are respectively abutted with the first extending section 121 and the second extending section 122, so that the reagent strip 5 is fixed in the sampling space 100 until the sample inlet 50 is correspondingly communicated with the sampling cavity 10;
S6: finally, the first direction in which the sampling cavity 10 extends is set to be the vertical direction, the cylinder 21 is detached from the first connector, and blood in the sampling cavity 10 drops to the sample inlet of the reagent strip 5 under the action of gravity, so that quantitative sampling detection is completed.
The method uses the blood quantitative sampling device of the application, the connection of the injector 2, the sampling component 1 and the catheter 3 is kept for at least two times of circulating sucking and pushing back operations, so that the tube sealing liquid or residual medicine in the catheter 3 can be eliminated, the waste blood and the replacement of the injector 2 are not needed, and the volume of the sampling cavity 10 is quantitative, and the sample is not needed to be sent to a laboratory for sampling by using micro quantitative sampling equipment, so that the reagent strip 5 is directly led into the sampling space 100, and the blood sample can be dropped into the reagent strip 5 under the action of gravity to realize on-site sampling and rapid detection, and the operation is simple.
The technical means disclosed by the scheme of the invention is not limited to the technical means disclosed by the embodiment, and also comprises the technical scheme formed by any combination of the technical features.
It should be noted that modifications and adaptations to the invention may occur to one skilled in the art without departing from the principles of the present invention and are intended to be within the scope of the present invention.
Claims (6)
1. A quantitative blood sampling device is characterized by comprising a syringe, a sampling component and a catheter,
The sampling assembly comprises a sampling tube and a sampling shell, wherein the sampling shell is provided with a sampling space for accommodating a reagent strip, the sampling tube is provided with a first end, a second end and a sampling cavity, the sampling cavity penetrates through the first end and the second end, the first end is provided with a first connector, and the second end is provided with a second connector; the second end is connected to the sampling space through the sampling shell in a penetrating way; the sampling cavity extends along a first direction, the sampling space is provided with a first opening and a second opening, the first opening penetrates through the second opening along a second direction, and the second direction is perpendicular to the first direction;
One end of the injector is detachably connected with the first connector, and one end of the catheter is detachably connected with the second connector; the reagent strip is provided with a sample inlet, and the sampling space is used for guiding the reagent strip to be introduced after the second connector is detached from the catheter so that the sampling cavity is communicated with the sample inlet;
During sampling detection, the syringe is taken down from the sampling assembly, and the reagent strip is led into the sampling space along the second direction; the blood in the sampling component drops into the reagent strips corresponding to the sampling space under the action of gravity, so that quantitative sampling detection is realized;
The sampling shell comprises a connecting section, a first extending section and a second extending section, wherein the connecting section is vertically arranged on the outer peripheral surface of the sampling tube, the first extending section and the second extending section extend from two opposite sides of the connecting section towards the direction away from the first end, and the first extending section and the second extending section are arranged at intervals and form the sampling space;
The end face, close to the second extension section, of the first extension section is provided with a first buckle, the end face, close to the first extension section, of the second extension section is provided with a second buckle, and the first buckle and the second buckle are arranged oppositely; the first buckle and the second buckle are used for abutting with the bottom end of the reagent strip after the reagent strip is clamped in the sampling space, so that the reagent strip is limited to be separated from the sampling space from the first direction.
2. The quantitative blood sampling device of claim 1, wherein the end surface of the first extension section, which is close to the second extension section, is provided with a first reinforcing section, the end surface of the second extension section, which is close to the first extension section, is provided with a second reinforcing section, and the first reinforcing section and the second reinforcing section are used for abutting against the top end of the reagent strip after the reagent strip is clamped in the sampling space.
3. The blood quantitative sampling device of any one of claims 1 or 2, wherein the sampling lumen comprises a first lumen and a second lumen, the first lumen having an inner diameter that is greater than an inner diameter of the second lumen.
4. A blood quantitative sampling device according to claim 3 wherein the bottom end of the first cavity is provided with a stepped section extending from the inner wall of the sampling cavity towards the central axis of the sampling cavity and circumscribing to form the second cavity.
5. The quantitative blood sampling device of claim 1, wherein the first connector is a first luer connector, the syringe comprises a push-pull rod and a barrel, one end of the push-pull rod is slidably arranged in the barrel, one end of the barrel, which is far away from the push-pull rod, is provided with a second luer connector, and the first luer connector is in locking connection with the second luer connector so that the sampling cavity is communicated with the barrel.
6. The blood quantitative sampling device of claim 1, wherein the second connector is a third luer connector, the catheter first end is provided with a fourth luer connector, and the third luer connector is in locking connection with the fourth luer connector.
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| CN212679114U (en) * | 2020-07-06 | 2021-03-12 | 广东昊朗医疗科技有限责任公司 | Device for accurately and quantitatively extracting blood sample |
| CN112932480A (en) * | 2019-11-26 | 2021-06-11 | 武汉普渡生物医药有限公司 | Finger blood trace quantitative sampling device and analysis method for rapid quantitative detection |
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| US20070031293A1 (en) * | 2005-08-04 | 2007-02-08 | Beatty Christopher C | Method and apparatus for collecting and diluting a liquid sample |
| EP4225402A4 (en) * | 2020-10-12 | 2024-10-16 | Becton, Dickinson and Company | BLOOD COLLECTION SYRINGE WITH HEMOLYSIS PROTECTION |
| CN219109460U (en) * | 2022-08-23 | 2023-06-02 | 广东昊朗医疗科技有限责任公司 | Accurate quantitative sampling device of blood |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112932480A (en) * | 2019-11-26 | 2021-06-11 | 武汉普渡生物医药有限公司 | Finger blood trace quantitative sampling device and analysis method for rapid quantitative detection |
| CN212679114U (en) * | 2020-07-06 | 2021-03-12 | 广东昊朗医疗科技有限责任公司 | Device for accurately and quantitatively extracting blood sample |
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