CN117017400A - Medical oncology medicine intervention treatment device - Google Patents
Medical oncology medicine intervention treatment device Download PDFInfo
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- CN117017400A CN117017400A CN202311060236.XA CN202311060236A CN117017400A CN 117017400 A CN117017400 A CN 117017400A CN 202311060236 A CN202311060236 A CN 202311060236A CN 117017400 A CN117017400 A CN 117017400A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12136—Balloons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
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- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
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- Hematology (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The invention discloses a medical oncology medicine interventional therapy device, which comprises a guide wire, an internal tube and a blood vessel bridge plug, wherein the guide wire extends into a blood supply aorta of a tumor and a blood return vein of the tumor; the end part of the built-in pipe extending to the outside of the body is provided with a mounting hole, a blood circulation joint and an oxygen supply joint; also comprises an external blood supply machine; the invention utilizes the guide wire to place the built-in tube and the vascular bridge plug along the blood vessel to the position close to the blood supply of the tumor, the oxygen membrane bag on the side wall of the vascular bridge plug is inflated by injecting oxygen for pressurization, the embolism of the blood supply aorta of the tumor is carried out, the built-in tube and the vascular bridge plug form an extracorporeal circulation pipeline at the two ends of the blood supply and blood return of the tumor, the blood supply and blood return system of the tumor are isolated independently, and simultaneously, the medicine treatment and the extracorporeal blood supply are carried out, the metastasis of cancer cells is avoided, and the rehabilitation effect of the interventional therapy of the tumor medicine is improved.
Description
Technical Field
The invention belongs to the technical field of other instruments for introducing media into a body, and particularly relates to a medical oncology drug interventional therapy device.
Background
In modern medicine, there are many pre-cancer treatment methods, wherein the main treatment methods include chemotherapy, radiation therapy and excision therapy, and the above methods achieve the purpose of treating cancer by directly or indirectly destroying tumor cells, and the corresponding medicines need to be injected into the tumor positions, so as to provide a medicine foundation for the subsequent treatment process.
In the treatment of gastroenterology and oncology, an interventional treatment method is generally adopted, and currently, tumor interventional treatment is a minimally invasive tumor treatment method for precisely treating tumors or relieving symptoms under the guidance of X-ray, CT, MRI or ultrasonic imaging equipment, wherein the tumor interventional treatment is divided into vascular interventional treatment and non-vascular interventional treatment.
The vascular intervention is that through super-selection, anticancer drugs and vascular obstructive positions are filled in the blood supply arteries of the tumor, the drugs are locally filled into the tumor, so that the concentration of the local antitumor drugs is improved, the blood supply arteries of the tumor can be embolized, the tumor killing effect is enhanced, and the toxic and side effects on the whole body are small; non-vascular intervention refers to percutaneous aspiration of viscera through a natural opening or diameter of a physiological cavity of a human body by using various instruments outside blood vessels under the guidance of medical imaging equipment, and mainly comprises percutaneous aspiration biopsy technology, endoprosthesis, percutaneous tumor ablation and radioactive particle implantation.
The vascular intervention comprises two vascular interventions, namely catheter arterial infusion chemotherapy (TAI) and catheter arterial chemotherapy embolism (TACE), which are gradually matured in the clinical operation process, wherein the anti-tumor drugs are selectively injected into the tumor blood supply arteries through the catheter by the catheter arterial infusion chemotherapy (TAI), so that the purposes of improving the concentration of the tumor tissue drugs and enhancing the anti-tumor effect of the perfusion area are achieved, the anti-tumor effect can be obviously provided compared with the conventional chemotherapy, the oxygen supply arteries of the tumor are found through the catheter arterial chemotherapy embolism (TACE), the anti-tumor drugs and the embolic agents are simultaneously injected into the oxygen supply arteries of the tumor by the catheter technology, the peripheral vascular branches of the blood supply arteries of the tumor tissue are occluded, the anti-tumor drugs are slowly released in the tumor area, and the local radiotherapy effect is achieved, and the vascular intervention has the advantages that: 1) The medicine is locked in local part to exert the maximum anti-tumor effect and under the effect of systemic toxicity, 2) the blood supply vessel of the tumor is blocked, so that the tumor loses blood supply, thereby inhibiting the growth of the tumor.
Among them, both transcatheter arterial infusion chemotherapy (TAI) which does not prevent cancer cells from transferring to other sites via blood, and Transcatheter Arterial Chemoembolization (TACE) which easily causes normal tissue near a tumor to die quickly by stopping blood supply and also embolizes peripheral vascular branches of blood supply arteries of tumor tissue with great difficulty, have significant drawbacks, and thus a new interventional therapeutic device is required.
Disclosure of Invention
Therefore, the invention aims to provide a medical oncology medicine interventional therapy device, which is provided with a guide wire and an inner catheter along a tumor blood supply artery and blood return veins in a patient, wherein the end part of the inner catheter is provided with a blood vessel bridge plug, the inner catheter and the blood vessel bridge plug are placed in a position close to the tumor blood supply along a blood vessel by using the guide wire, an oxygen membrane bag on the side wall of the blood vessel bridge plug is inflated by injecting oxygen for pressurizing, the tumor blood supply artery is embolized, an extracorporeal circulation pipeline is formed at the two ends of the tumor blood supply blood return by using the inner catheter and the blood vessel bridge plug, a tumor blood supply blood return system is isolated independently, medicine therapy and extracorporeal blood supply are carried out, cancer cell metastasis is avoided, and the rehabilitation effect of the tumor medicine interventional therapy is improved.
In order to achieve the aim, the medical oncology medicine interventional therapy device comprises a guide wire extending into a tumor blood supply aorta, an inner catheter sleeved on the guide wire, a guide wire I extending into a tumor blood return vein and an inner catheter I sleeved on the guide wire I, wherein the ends of the inner catheter and the inner catheter I are respectively provided with a vascular bridge plug for embolizing the blood supply aorta and a vascular bridge plug I for embolizing the blood return vein, the outer walls of the vascular bridge plug and the vascular bridge plug I are respectively provided with a containing groove, the containing groove is internally provided with an oxygen membrane bag for inflating oxygen,
a central channel is arranged in the built-in tube and around the guide wire, a liquid outlet cavity communicated with the central channel is arranged in the blood vessel bridge plug and around the guide wire, and a liquid outlet communicated with one side of the blood supply aorta close to the tumor is arranged at the end part of the blood vessel bridge plug;
a central channel I is arranged in the built-in tube I and around the guide wire I, a liquid inlet cavity communicated with the central channel I is arranged in the vessel bridge plug I and around the guide wire I, and a liquid inlet communicated with one side of a blood return vein close to a tumor is arranged at the end part of the vessel bridge plug I;
the end part of the built-in tube extending to the outside of the body is provided with a mounting hole for accommodating the insertion of a guide wire, and the side wall of the built-in tube extending to the outside of the body is provided with a blood circulation joint and an oxygen supply joint;
the end part of the built-in tube I extending to the outside of the body is provided with a mounting hole I for accommodating insertion of a guide wire I, and the side wall of the built-in tube I extending to the outside of the body is provided with a blood return circulation joint and an oxygen supply joint I;
the blood supply device also comprises an external blood supply machine, wherein an external circulation pipeline is arranged on the external blood supply machine, and two ends of the external circulation pipeline are communicated with a blood supply circulation joint and a blood return circulation joint.
Further, the guide wire is set to 0.8mm-1.2mm.
Further, the diameter of the inner tube and the inner tube I is set to be 1.8-2mm.
Further, the diameters of the blood vessel bridge plug and the blood vessel bridge plug I are set to be 2-2.4mm, a conical surface is arranged on the blood vessel bridge plug, which is close to the edge, at the end part of the other end of the blood vessel bridge plug, which is far away from the liquid outlet, a blood supply hole communicated with one end of the tumor blood supply aorta, which is far away from the tumor, is arranged on the conical surface, and a blood supply channel which is communicated with the blood supply hole and the liquid outlet cavity is arranged on the blood vessel bridge plug.
Further, the built-in tube and the vascular bridge plug are arranged into an integral molding body, and the vascular bridge plug is formed by laser processing of medical PC materials.
The invention has the beneficial effects that:
the medical oncology medicine interventional therapy device is provided with a guide wire and an internal tube in a patient along a tumor blood supply artery and a blood return vein, the end part of the internal tube is provided with a blood vessel bridge plug, the internal tube and the blood vessel bridge plug are placed in the position close to the tumor blood supply along a blood vessel by using the guide wire, an oxygen membrane bag on the side wall of the blood vessel bridge plug is inflated by injecting oxygen for pressurizing, the embolism tumor blood supply aorta is carried out, an extracorporeal circulation pipeline is formed at the two ends of the tumor blood supply blood return by using the internal tube and the blood vessel bridge plug, a tumor blood supply blood return system is isolated independently, medicine therapy and extracorporeal blood supply are carried out, cancer cell metastasis is avoided, and the rehabilitation effect of the tumor medicine interventional therapy is improved.
Drawings
FIG. 1 is a schematic structural view of a medical oncology drug interventional therapy device of the present invention;
FIG. 2 is a vertical partial enlarged view of a vascular bridge plug in the medical oncology drug interventional therapy device of the present invention;
FIG. 3 is a cross-sectional enlarged view of a vascular bridge plug in the medical oncology drug interventional therapy device of the present invention;
fig. 4 is a schematic structural diagram of an extracorporeal circulation pipeline of the medical oncology drug interventional therapy device.
Reference numerals: 1-tumor; 2-blood supply aorta; 3-blood return vein; 4-tumor blood capillaries; 5-normal blood capillaries; 6-a guide wire; 7-a built-in tube; 8-vessel bridge plug; 9-a guide wire I; 10-a built-in pipe I; 11-vascular bridge plug I; 12-a receiving groove; 13-oxygen membrane vesicles; 14-a central passage; 15-a liquid outlet cavity; 16-a liquid outlet; 17-blood supply channel; 18-supplying blood holes; 19-an oxygen manifold; 20-oxygen passage; 21-blood circulation joint; 22-oxygen supply joint; 23-a blood return circulation junction; 24-an oxygen supply joint I; 25-an extracorporeal circulation circuit; 26-an in vitro blood supply machine.
Description of the embodiments
Preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings.
1-4 are schematic structural views of the medical oncology drug interventional therapy device of the invention; the invention discloses a medical medicine interventional therapy device for oncology, which comprises a guide wire 6 extending into a blood supply aorta 2 of a tumor 1, an embedment tube 7 sleeved on the guide wire 6, a guide wire I9 extending into a blood return vein 3 of the tumor 1, and an embedment tube I10 sleeved on the guide wire I9, wherein the ends of the embedment tube 7 and the embedment tube I10 are respectively provided with a vascular bridge plug 8 for embolizing the blood supply aorta and a vascular bridge plug I11 for embolizing the blood return vein, the outer walls of the vascular bridge plug 8 and the vascular bridge plug I11 are respectively provided with a containing groove 12, the containing groove 12 is internally provided with an oxygen membrane bag 13 for inflating oxygen,
a central channel 14 is arranged in the inner tube 7 around the guide wire 6, a liquid outlet cavity 15 communicated with the central channel 14 is arranged in the blood vessel bridge plug 8 around the guide wire 6, and a liquid outlet 16 communicated with one side of the blood supply aorta 2 close to the tumor is arranged at the end part of the blood vessel bridge plug 8;
a central channel I is arranged in the built-in tube I10 and positioned around the guide wire I, a liquid inlet cavity communicated with the central channel I is arranged in the blood vessel bridge plug I and positioned around the guide wire I, and a liquid inlet communicated with one side of a blood return vein close to a tumor is arranged at the end part of the blood vessel bridge plug I;
the end part of the built-in tube 7 extending to the outside of the body is provided with a mounting hole for accommodating the insertion of the guide wire 6, and the side wall of the built-in tube 7 extending to the outside of the body is provided with a blood circulation joint 21 and an oxygen supply joint 22;
the end part of the built-in tube I extending to the outside of the body is provided with a mounting hole I for accommodating insertion of a guide wire I, and the side wall of the built-in tube I extending to the outside of the body is provided with a blood return circulation joint 23 and an oxygen supply joint I24;
the blood supply device further comprises an external blood supply machine 26, an external circulation pipeline 25 is arranged on the external blood supply machine 26, and two ends of the external circulation pipeline 25 are communicated with the blood supply circulation joint 21 and the blood return circulation joint 23.
In this embodiment, all be provided with seal wire and built-in pipe along tumour blood supply artery and back blood intravenous in the patient, built-in pipe tip sets up the blood vessel bridging plug, utilize the seal wire to put into built-in pipe and blood vessel bridging plug along the blood vessel and be close to tumour blood supply department, make the oxygen membrane bag inflation on the blood vessel bridging plug lateral wall through the injection oxygen pressurization, carry out embolism tumour blood supply aorta, utilize built-in pipe and blood vessel bridging plug to form the extracorporeal circulation pipeline at tumour blood supply back blood both ends, keep apart tumour blood supply blood return system alone, carry out the medicine treatment simultaneously and extracorporeal blood supply, avoid cancer cell metastasis, improve tumour medicine intervention treatment rehabilitation effect.
In a preferred embodiment, the guide wire 6 is set to be 0.8mm-1.2mm, the diameters of the built-in tube 7 and the built-in tube I10 are set to be 1.8-2mm, and the structure of the embodiment avoids thrombus and improves the interventional treatment efficiency.
In a preferred embodiment, the diameters of the blood vessel bridge plug 8 and the blood vessel bridge plug I11 are set to be 2-2.4mm, the end part of the other end of the blood vessel bridge plug 8, which is far away from the liquid outlet, is close to the edge, a conical surface is arranged, a blood supply hole 18 communicated with one end of the tumor blood supply aorta, which is far away from the tumor, is arranged on the conical surface, and a blood supply channel 17 communicated with the blood supply hole and the liquid outlet cavity is arranged on the blood vessel bridge plug, so that the blood vessel bridge plug 8 and the blood vessel bridge plug I11 can circulate blood at two sides of the blood vessel bridge plug 8 and the blood vessel bridge plug I11 before an embolic pipeline is not formed, and thrombus is avoided.
In a preferred embodiment, the inner tube 7 and the vascular bridge 8 are provided as an integral body, the vascular bridge is formed by laser processing of medical PC materials, and the structure is convenient for processing operation in the embodiment.
The medical oncology drug interventional therapy device of the embodiment performs interventional therapy training method under a transparent visual model as follows:
1) Constructing an interventional therapy training system: the interventional training system comprises an indwelling needle puncture kit and a puncture model, wherein,
the indwelling needle puncture kit comprises an indwelling needle, a guide wire and an indwelling tube;
the puncture model comprises a transparent simulation part for simulating tumor tissues, a vein tube for simulating vein vessels, a liquid supply box, an arterial tube for simulating vein vessels, a delivery pump for delivering simulated blood and a switch for controlling the start/stop of the delivery pump, wherein containers which are communicated with the vein tube and the arterial tube are arranged in the simulation part, and the container is used for tumor blood supply capillary vessels and normal blood supply capillary vessels.
2) Starting a delivery pump, so that simulated blood returns to the liquid supply box along the liquid supply box, the delivery pump, the arterial tube, the transparent simulation part and the venous tube, and setting the pressure of the arterial tube and the venous tube so as to simulate arterial pressure and veins;
3) Determining puncture points on arterial ducts and venous ducts, and sterilizing the puncture points;
4) On arterial and venous vessels; holding an indwelling needle in the puncture kit, performing puncture training according to the indwelling needle specification, and introducing a guide wire into the transparent simulation part to be positioned between a tumor blood-supply capillary and a normal blood-supply capillary;
5) Introducing an indwelling needle built-in tube between a tumor blood supply capillary and a normal blood supply capillary along a guide wire;
6) The external blood circulation joint and the return blood circulation joint of the built-in tube donors of the arterial tube and the venous tube are connected with a second circulation system, and the arterial tube and the venous tube are plugged by the vascular bridge plug and the vascular bridge plug I, so that internal circulation and external double circulation are realized.
In interventional therapy training of the interventional therapy device, the arterial tube and the venous tube are constructed in the puncture model, the venous tube passes through the simulation part, the purpose of simulating blood vessels can be achieved, the conveying pump and the container are constructed in the puncture model, the conveying pump, the arterial tube and the venous tube are communicated with the container, accordingly, a circulation channel for simulating blood can be established in the puncture model, the purpose of simulating blood flow in the blood vessels can be achieved, the puncture model and the puncture training method are enabled to be more vivid, the simulated blood in the arterial tube and the venous tube has certain pressure, the problem of simulating arterial blood and venous blood pressure can be solved, after the arterial tube and the venous tube are plugged by the vascular bridge plug I, internal and external double circulation of the transparent simulation part is achieved, different color liquids are added through the transparent simulation part, the change of the liquid color in the internal and external double circulation is observed, and the using state of the interventional therapy device for oncology medicine is mastered.
The medical oncology drug interventional therapy device of the embodiment performs interventional clinical therapy training under a mice experiment as follows:
1) Animals and groupings: randomly dividing 20 mice into an experimental group a (10) and a group b control group (10), and numbering and feeding;
2) And (3) establishing a model: taking tumor cells, washing the tumor cells with sterile physiological saline, properly diluting, adding 10 microliters of 0.4% phenol blue into 40 microliters of cell suspension, staining and microscopic examination and counting to obtain the tumor cell suspension with the concentration of 3 x 10 6 Tumor cell suspensions per ml, 0.1 ml of tumor cell suspension was inoculated at different sites of each 2 mice of the experimental group a (10) and the control group b (10), and the distribution thereof (1-2 cases of kidney, 3-4 cases of colon, 5-6 cases of uterus, 7-8 cases of abdomen and 9-10 cases of urethra);
3) Establishing an interventional therapy model: establishing a tumor drug interventional therapy device for mice in the experiment A group; forming an in-vivo and in-vitro double-circulation blood channel;
4) After inoculation, the inoculation part is observed daily for infection, and the tumor has natural regression after growth.
As a result, in the experimental process, the white mice die rapidly due to the thrombus arrival caused by the vascular bridge plug, wherein the tumor growth of the white mice in the experimental group a is obviously slower than that of the white mice in the control group b, thus adopting an in-vitro and in-vivo double-circulation blood channel, and the application of the drug intervention treatment in the extracorporeal circulation blood channel has obvious inhibition effect on the tumor growth and diffusion.
Finally, it is noted that the above-mentioned preferred embodiments are only intended to illustrate rather than limit the invention, and that, although the invention has been described in detail by means of the above-mentioned preferred embodiments, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the scope of the invention as defined by the appended claims.
Claims (5)
1. Medical oncology medicine intervenes treatment device, its characterized in that: comprises a guide wire extending into a tumor blood supply aorta, a built-in tube sleeved on the guide wire, a guide wire I extending into a tumor blood return vein and a built-in tube I sleeved on the guide wire I, wherein the ends of the built-in tube and the built-in tube I are respectively provided with a vascular bridge plug for embolizing the blood supply aorta and a vascular bridge plug I for embolizing the blood return vein, the outer walls of the vascular bridge plug and the vascular bridge plug I are respectively provided with a containing groove, an oxygen membrane bag for inflating oxygen is arranged in the containing groove,
a central channel is arranged in the built-in tube and around the guide wire, a liquid outlet cavity communicated with the central channel is arranged in the blood vessel bridge plug and around the guide wire, and a liquid outlet communicated with one side of the blood supply aorta close to the tumor is arranged at the end part of the blood vessel bridge plug;
a central channel I is arranged in the built-in tube I and around the guide wire I, a liquid inlet cavity communicated with the central channel I is arranged in the vessel bridge plug I and around the guide wire I, and a liquid inlet communicated with one side of a blood return vein close to a tumor is arranged at the end part of the vessel bridge plug I;
the end part of the built-in tube extending to the outside of the body is provided with a mounting hole for accommodating the insertion of a guide wire, and the side wall of the built-in tube extending to the outside of the body is provided with a blood circulation joint and an oxygen supply joint;
the end part of the built-in tube I extending to the outside of the body is provided with a mounting hole I for accommodating insertion of a guide wire I, and the side wall of the built-in tube I extending to the outside of the body is provided with a blood return circulation joint and an oxygen supply joint I;
the blood supply device also comprises an external blood supply machine, wherein an external circulation pipeline is arranged on the external blood supply machine, and two ends of the external circulation pipeline are communicated with a blood supply circulation joint and a blood return circulation joint.
2. The medical oncology drug intervention device of claim 2 wherein: the guide wire is arranged to be 0.8mm-1.2mm.
3. The medical oncology drug intervention device of claim 3 wherein: the diameters of the built-in pipe and the built-in pipe I are set to be 1.8-2mm.
4. The medical oncology drug intervention device of claim 1 wherein: the diameter of the blood vessel bridge plug and the diameter of the blood vessel bridge plug I are set to be 2-2.4mm, a conical surface is arranged on the blood vessel bridge plug, which is close to the edge, at the end part of the other end of the blood vessel bridge plug, which is far away from the liquid outlet, a blood supply hole communicated with one end of the tumor blood supply aorta, which is far away from the tumor, is arranged on the conical surface, and a blood supply channel which is communicated with the blood supply hole and the liquid outlet cavity is arranged on the blood vessel bridge plug.
5. The medical oncology drug intervention device of claim 1 wherein: the built-in tube and the vascular bridge plug are arranged as an integrated body, and the vascular bridge plug is formed by laser processing of medical PC materials.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311060236.XA CN117017400A (en) | 2023-08-22 | 2023-08-22 | Medical oncology medicine intervention treatment device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311060236.XA CN117017400A (en) | 2023-08-22 | 2023-08-22 | Medical oncology medicine intervention treatment device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117017400A true CN117017400A (en) | 2023-11-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311060236.XA Withdrawn CN117017400A (en) | 2023-08-22 | 2023-08-22 | Medical oncology medicine intervention treatment device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117017400A (en) |
-
2023
- 2023-08-22 CN CN202311060236.XA patent/CN117017400A/en not_active Withdrawn
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20231110 |