CN116898898B - Moxa stick with the effect of activating blood circulation, removing blood stasis and removing dampness, and preparation method thereof - Google Patents

Abstract

The invention discloses a moxa stick with the effect of activating blood circulation, removing blood stasis and removing dampness and a preparation method thereof, and relates to the technical field of moxa stick processing. The invention uses high-quality moxa as the main material, and adds moxa stick with the effect of activating blood circulation, removing blood stasis and removing dampness. Traditional Chinese medicine is used as an auxiliary material, and a simple and easy operation process is used to prepare moxa sticks. Under the condition of simplifying the formula of traditional Chinese medicine, it can not only reduce the cost of moxa sticks and improve the efficacy of moxibustion, but also solve the disclosed problem of directly adding moxa sticks to moxa sticks. Traditional Chinese medicine powder is used to improve the technical problems of moxibustion efficacy, improve the utilization rate of traditional Chinese medicine and the safety of moxibustion.

Description

Moxa stick with the effect of activating blood circulation, removing blood stasis and removing dampness, and preparation method thereof

Technical areas:

The present invention relates to the technical field of moxa stick processing, and specifically relates to a moxa stick with the effect of activating blood circulation, removing blood stasis and removing dampness, and a preparation method thereof.

Background technique:

Moxibustion, also known as moxibustion therapy or moxibustion, uses moxa sticks and moxa sticks made from moxa leaves to stimulate acupuncture points or specific parts of the human body. It regulates the disordered physiological and biochemical functions of the human body by stimulating the activity of meridian qi, thereby achieving prevention and control. A treatment method for the purpose of treating disease. The mechanism of action of moxibustion is similar to that of acupuncture, and it has complementary therapeutic effects with acupuncture. It has many advantages such as simple operation, low cost, and significant effects.

A moxa stick is a long cylindrical roll made of moxa velvet wrapped in rolling paper, and a moxa stick is a relatively short moxa stick. The choice of moxa stick or moxa column is mainly determined by the moxibustion device. If the moxibustion device is relatively large, moxa sticks are usually chosen; if the moxibustion device is small, moxa sticks are usually chosen.

Moxa velvet is obtained by repeatedly drying, beating, crushing, and sifting out impurities and dust from moxa leaves of the Asteraceae plant. It is as soft as velvet, flammable but does not cause flames, and has a fragrant smell. Moxa is the raw material for making moxa sticks and the main material used in moxibustion. It has the functions of stimulating menstruation, activating meridians, warming menstruation and stopping bleeding, dispersing cold and relieving pain, and maintaining health. Moxa sticks made of pure moxa velvet have the stimulating effect of burning acupuncture points and warm ironing. Although they also have certain health care effects, due to insufficient stimulation and permeability, the curative effect is not significant and the course of treatment is long.

Patent CN114306563A discloses a gynecological menopausal prescription moxibustion, including mugwort leaves, cinnamon, white peony root, dried ginger, licorice, dragon bone, oyster, Morinda officinalis, fairy spleen, aconite, Evodia, Poria, Magnolia officinalis, cardamom , Angelica sinensis, Ligusticum chuanxiong, Atractylodes macrocephala, Perilla leaf, Astragalus membranaceus, Rehmannia glutinosa, tangerine peel, Codonopsis pilosula, Cyperus rotunda, Corydalis corydalis, frankincense, turmeric, and its preparation method includes the following steps: S1. Weigh each component according to the formula, wash and dry, Crush to obtain crude drug powder; S2, blend the crude drug powder obtained in step S1 with moxibustion; S3, hydraulically press the mixture obtained in step S2, cut and package, to obtain the finished product. This patent adds a variety of traditional Chinese medicines to moxa to improve the therapeutic effect of moxibustion on various gynecological menopausal symptoms. However, because it uses dry crude drug powder and moxa to be physically mixed, the pressed molding properties are poor, and the prepared moxa sticks are not packaged. During the transportation process, the crude drug powder is easily scattered and cannot achieve the expected effect. During the moxibustion process, there is a safety hazard that the drug residue is easily dropped when burned, causing burns.

Contents of the invention:

The technical problem to be solved by the present invention is to provide a moxa stick with the effect of activating blood circulation, removing blood stasis and removing dampness, and a preparation method thereof. The moxa stick is mainly made of moxa velvet, and is added with traditional Chinese medicine having the effect of activating blood circulation and removing blood stasis, and simplifies the formula of traditional Chinese medicine. Under the conditions, the cost of moxa sticks can be reduced, the effect of moxibustion can be improved, and the course of treatment can be greatly shortened.

The technical problems to be solved by the present invention are achieved by adopting the following technical solutions:

The first object of the present invention is to provide a method for preparing moxa sticks with the effect of activating blood circulation, removing blood stasis and removing dampness, which includes the following preparation steps:

(1) Choose aged moxa velvet that is earthy or golden in color, soft as cotton, delicate and fluffy, and has a mellow moxa flavor;

(2) Mix Angelicae Sinensis, Ligusticum Chuanxiong, Milla Sinensis, Frankincense, Cinnamon, and Borneol in proportion, crush them into fine powder, and sift to obtain medicinal powder;

(3) Spray the adhesive into the medicinal powder and mix evenly to obtain the excipients;

(4) Add the auxiliary materials to the moxa velvet, mix thoroughly, spread it flatly on rolling paper, press it into a long strip, and dry it to obtain moxa sticks.

Preferably, the mass ratio of Angelicae Sinensis, Ligusticum Chuanxiong, Spatholobus, Frankincense, Cinnamon and Borneol is (5~20):(5~20):(5~20):(1~10):(1~10 ): (0.5～5).

Preferably, the mesh size of the sieve is 100 to 200 mesh.

Preferably, the mass ratio of the pharmaceutical powder to the binder is 1: (1-2).

Preferably, the adhesive is prepared from hydroxyethyl cellulose and water, with a mass concentration of 5 to 10% and a preparation temperature of 80 to 90°C.

Further preferably, the hydroxyethyl molar substitution degree of the hydroxyethyl cellulose is 1.8 to 2.0.

Preferably, the mass ratio of moxa down to medicinal powder is 100: (1-10).

Preferably, the rolling paper is one of moxa paper, mulberry paper, and tissue paper.

Preferably, the drying temperature is 50-60°C to reduce the moisture content of the moxa sticks to less than 5%.

The second object of the present invention is to provide a method for preparing moxa sticks with the effect of activating blood circulation, removing blood stasis and removing dampness, including the following preparation steps:

(1) Choose aged moxa velvet that is earthy or golden in color, soft as cotton, delicate and fluffy, and has a mellow moxa flavor;

(2) Mix the ethanol extracts of Angelicae Sinensis, Ligusticum chuanxiong, Millet Spatholobus, Frankincense, Cinnamon, Borneol and Platycodon in proportion, then grind them into fine powder, and sieve to obtain medicinal powder;

(3) Spray the adhesive into the medicinal powder and mix evenly to obtain the excipients;

(4) Add the auxiliary materials to the moxa velvet, mix thoroughly, spread it flatly on rolling paper, press it into a long strip, and dry it to obtain moxa sticks.

Preferably, the mass ratio of the ethanol extracts of Angelicae Sinensis, Ligusticum Chuanxiong, Millet Spatholobus, Frankincense, Cinnamon, Borneol and Platycodon is (5~20):(5~20):(5~20):(1~10 ):(1～10):(0.5～5):(0.01～0.1).

Lisianthus is a herbaceous plant of the genus Lisianthus in the family Gentianaceae. In the present invention, the blood-activating and blood-stasis-removing effect of moxa sticks is enhanced by adding an appropriate amount of the alcohol extract of Lisianthus.

Preferably, the preparation method of the lisianthus ethanol extract is: reflux extraction of dried lisianthus petals with ethanol, filtering, combining the filtrate, concentrating under reduced pressure, freeze-drying, and crushing to obtain the lisianthus ethanol extract.

Further preferably, the ethanol is an ethanol solution with a concentration of 75 to 85 Vol%, and the number of reflux extractions is 2 to 3 times. The amount of ethanol used in each reflux extraction is 5 to 10 times the dry weight of lisianthus petals, and the reflux extraction time is It is 1~5h.

Preferably, the mesh size of the sieve is 100 to 200 mesh.

Preferably, the mass ratio of the pharmaceutical powder to the binder is 1: (1-2).

Preferably, the adhesive is prepared from hydroxyethyl cellulose and water, with a mass concentration of 5 to 10% and a preparation temperature of 80 to 90°C.

Further preferably, the hydroxyethyl molar substitution degree of the hydroxyethyl cellulose is 1.8 to 2.0.

Preferably, the mass ratio of moxa down to medicinal powder is 100: (1-10).

Preferably, the rolling paper is one of moxa paper, mulberry paper, and tissue paper.

Preferably, the drying temperature is 50-60°C to reduce the moisture content of the moxa sticks to less than 5%.

Although the adhesive prepared by adding hydroxyethyl cellulose and water can promote the uniform dispersion of the medicinal powder on the moxa velvet, the viscosity drops significantly after drying and cannot guarantee the firm adhesion of the medicinal powder on the moxa velvet. Therefore, it cannot completely solve the problem of moxa velvet. During the packaging and transportation process of the strips, there is a problem that the crude drug powder is easily scattered and cannot achieve the expected effect. During the moxibustion process, there is a safety hazard that the drug residue is easily dropped when burned, causing burns. To this end, the present invention also prepares another adhesive, which can achieve uniform and firm adhesion of the medicinal powder on the moxa sticks under the same concentration and dosage of the adhesive, which can effectively solve the problem of packaging and transportation of moxa sticks. As well as the above-mentioned technical problems existing in the moxibustion process; and when fully burned, no toxic gas is produced, which will not affect the safety of the use of moxa sticks.

Preferably, the adhesive is prepared by adding water to a poloxamer-terminated condensation polymer, with a mass concentration of 5 to 10% and a preparation temperature of 80 to 90°C.

Further preferably, the poloxamer-terminated condensation polymer is formed by the polycondensation reaction of poloxamer and 1,3-bis(chloromethyl)-1,1,3,3-tetramethyldisiloxane. production.

The third object of the present invention is to provide a moxa stick prepared according to the aforementioned preparation method and having the effect of activating blood circulation, removing blood stasis and removing dampness.

Moxa Rong: Bitter, pungent, warm in nature, it has the effects of stimulating menstruation, activating meridians, warming menstruation and stopping bleeding, dispersing cold and relieving pain.

Angelica sinensis: pungent, sweet, warm in nature, has the effects of nourishing blood and activating blood circulation, regulating menstruation and relieving pain, and moistening intestines and laxative.

Ligusticum chuanxiong: pungent in flavor and warm in nature, it has the effects of promoting blood circulation and relieving pain, promoting qi and relieving depression, and dispelling wind and dampness.

Millet Spatholobi: bitter, sweet, warm in nature, has the effects of promoting blood circulation, regulating menstruation and relieving pain, relaxing menstruation and activating collaterals.

Frankincense: pungent, bitter, warm in nature, has the effects of promoting blood circulation, promoting qi, relieving pain, reducing swelling and promoting muscle growth.

Cinnamon: pungent, bitter, and very hot in nature. It has the effects of warming the meridians, dispersing cold and relieving pain, and inducing fire and replenishing energy.

Borneol: pungent, bitter, slightly cold in nature, has the effect of resuscitating the mind, increasing skin penetration, stimulating acupuncture points when burning moxa sticks, stimulating menstrual qi, opening up the local skin texture, introducing the medicine into the menstruation, promoting qi and blood circulation.

The beneficial effects of the present invention are: the present invention uses high-quality moxa as the main material, adds Chinese medicine with the effect of activating blood circulation, removing blood stasis and removing dampness as auxiliary materials, and adopts a simple and easy operation process to process and prepare moxa sticks, while simplifying traditional Chinese medicine Under the conditions of the formula, it can not only reduce the cost of moxa sticks and improve the efficacy of moxibustion, but also solve the technical problems existing in the disclosed method of directly adding Chinese medicine powder to moxa to improve the efficacy of moxibustion, improve the utilization rate of traditional Chinese medicine and the effectiveness of moxibustion. Safety of moxibustion.

Detailed ways:

In order to make it easy to understand the technical means, creative features, objectives and effects of the present invention, the present invention will be further elaborated below in conjunction with specific embodiments.

Description of the sources of raw materials in the following examples and comparative examples:

Aged mugwort was purchased from Nanyang Shennong mugwort Biological Products Co., Ltd., product grade SN06.

Hydroxyethyl cellulose was purchased from Shandong Tenasi Chemical Co., Ltd., the model is HE-40000S, and the hydroxyethyl molar substitution degree is 1.8 to 2.0.

Preparation of lisianthus ethanol extract: 500g of dried lisianthus petals were refluxed and extracted with ethanol. The ethanol was an ethanol solution with a concentration of 80 Vol%. The number of reflux extractions was 3 times. The amount of ethanol used in each reflux extraction was the dry weight of lisianthus petals. 5 times, each reflux extraction time is 3 hours, filter, combine the filtrate, concentrate under reduced pressure, freeze-dry, and grind into fine powder to obtain the alcohol extract of Platycodon grandiflorum.

Poloxamer 182 was purchased from Nantong Aches Chemical Co., Ltd., with an average molecular weight of 2500.

Synthesis of poloxamer-terminated condensation polymer A: Add 0.2 mol poloxamer 182 and 0.1 mol 1,3-bis(chloromethyl)-1,1,3,3-tetramethyldisiloxane to tetrahydrofuran Alkane, stir and dissolve completely, add 0.2 mol triethylamine, heat to boiling state and then reflux reaction, wait until TLC monitors 1,3-bis(chloromethyl)-1,1,3,3-tetramethyldisiloxane After the reaction is complete, stop heating, cool to room temperature naturally, wash with water at room temperature three times, filter, dry the filter residue at 80°C, grind into fine powder, and pass through a 100-mesh sieve to obtain poloxamer-terminated condensation polymer A.

Synthesis of poloxamer-terminated condensation polymer B: Add 0.2 mol poloxamer 182 and 0.1 mol dichloroethyl ether to tetrahydrofuran, stir and dissolve completely, add 0.2 mol triethylamine, heat to boiling state and then reflux for reaction. TLC monitors that after the reaction of dichloroethyl ether is complete, stop heating, cool to room temperature naturally, wash with water at room temperature three times, filter, dry the filter residue at 80°C, grind into fine powder, and pass through a 100-mesh sieve to obtain poloxamer-terminated condensation polymer B.

Example 1

(1) Choose aged moxa velvet that is earthy or golden in color, soft as cotton, delicate and fluffy, and has a mellow moxa flavor.

(2) Mix Angelica sinensis, Ligusticum chuanxiong, Milla sinensis, frankincense, cinnamon and borneol in proportion and grind them into fine powder. The mass ratio of angelica, chuanxiong, chicken bloodvine, frankincense, cinnamon and borneol is 15:15:15:5. :3:0.5, pass through a 100-mesh sieve to obtain medicinal powder.

(3) Spray adhesive into the medicinal powder. The mass ratio of medicinal powder to adhesive is 1:1. The adhesive is prepared from hydroxyethyl cellulose and water. The mass concentration is 10% and the preparation temperature is 80°C. , mix evenly to obtain auxiliary materials.

(4) Add the auxiliary materials to the moxa velvet. The mass ratio of moxa velvet to medicated powder is 100:5. Mix it thoroughly and spread it evenly on the moxa velvet paper. Press it into a long strip and dry it at 60°C to reduce the moisture content of the moxa stick to 100:5. Below 5%, moxa sticks are obtained.

Example 2

(1) Choose aged moxa velvet that is earthy or golden in color, soft as cotton, delicate and fluffy, and has a mellow moxa flavor.

(2) Mix Angelica sinensis, Ligusticum chuanxiong, Milla sinensis, frankincense, cinnamon and borneol in proportion and grind them into fine powder. The mass ratio of angelica, chuanxiong, chicken bloodvine, frankincense, cinnamon and borneol is 15:20:10:4. :4:0.5, pass through a 100-mesh sieve to obtain medicinal powder.

(3) Spray adhesive into the medicinal powder. The mass ratio of medicinal powder to adhesive is 1:2. The adhesive is prepared from hydroxyethyl cellulose and water. The mass concentration is 5% and the preparation temperature is 85°C. , mix evenly to obtain auxiliary materials.

(4) Add the auxiliary materials to the moxa sticks. The mass ratio of the moxa sticks to the medicinal powder is 100:5. Mix them thoroughly and spread them flatly on the mulberry paper. Press them into strips and dry them at 50°C to reduce the moisture content of the moxa sticks to 100:5. Below 5%, moxa sticks are obtained.

Example 3

(1) Choose aged moxa velvet that is earthy or golden in color, soft as cotton, delicate and fluffy, and has a mellow moxa flavor.

(2) Mix Angelica sinensis, Ligusticum chuanxiong, Milla sinensis, frankincense, cinnamon and borneol in proportions and grind them into fine powder. The mass ratio of angelica, chuanxiong, chicken bloodvine, frankincense, cinnamon and borneol is 20:10:15:3. :4:0.5, pass through a 100-mesh sieve to obtain medicinal powder.

(3) Spray adhesive into the medicinal powder. The mass ratio of medicinal powder to adhesive is 1:2. The adhesive is prepared from hydroxyethyl cellulose and water. The mass concentration is 5% and the preparation temperature is 80°C. , mix evenly to obtain auxiliary materials.

(4) Add the auxiliary materials to the moxa sticks. The mass ratio of moxa sticks to medicinal powder is 100:8. Mix them thoroughly and spread them flatly on mulberry paper. Press them into strips and dry them at 55°C to reduce the moisture content of the moxa sticks to 100:8. Below 5%, moxa sticks are obtained.

Example 4

(1) Choose aged moxa velvet that is earthy or golden in color, soft as cotton, delicate and fluffy, and has a mellow moxa flavor.

(2) Mix Angelica sinensis, Ligusticum chuanxiong, Milla sinensis, Frankincense, cinnamon and Borneol in proportion and grind them into fine powder. The mass ratio of Angelica sinensis, Ligusticum chuanxiong, Milla sinensis, Frankincense, cinnamon and Borneol is 15:10:20:4. :3:0.5, pass through a 100-mesh sieve to obtain medicinal powder.

(3) Spray adhesive into the medicinal powder. The mass ratio of medicinal powder to adhesive is 1:1. The adhesive is prepared from hydroxyethyl cellulose and water. The mass concentration is 10% and the preparation temperature is 90°C. , mix evenly to obtain auxiliary materials.

(4) Add the auxiliary materials to the moxa sticks. The mass ratio of moxa sticks to medicated powder is 100:8. Mix them thoroughly and spread them flatly on cotton paper. Press them into long strips and dry them at 60°C to reduce the moisture content of the moxa sticks to 100:8. Below 5%, moxa sticks are obtained.

Example 5

(1) Choose aged moxa velvet that is earthy or golden in color, soft as cotton, delicate and fluffy, and has a mellow moxa flavor.

(2) Mix Angelica sinensis, Ligusticum chuanxiong, Millaplasia sinensis, frankincense, cinnamon and borneol in proportion and grind them into fine powder. The mass ratio of angelica sinensis, Chuanxiong rhizome, chicken bloodvine, frankincense, cinnamon and borneol is 20:15:10:3. :3:0.5, pass through a 100-mesh sieve to obtain medicinal powder.

(3) Spray adhesive into the medicinal powder. The mass ratio of medicinal powder to adhesive is 1:1. The adhesive is prepared from hydroxyethyl cellulose and water. The mass concentration is 8% and the preparation temperature is 80°C. , mix evenly to obtain auxiliary materials.

(4) Add the auxiliary materials to the moxa sticks. The mass ratio of moxa sticks to medicinal powder is 100:5. Mix them thoroughly and spread them flatly on mulberry paper. Press them into strips and dry them at 55°C to reduce the moisture content of the moxa sticks to 100:5. Below 5%, moxa sticks are obtained.

Example 6

The difference between Example 6 and Example 1 is that the alcohol extract of Platycodon grandiflorum is also added in step (2).

(1) Choose aged moxa velvet that is earthy or golden in color, soft as cotton, delicate and fluffy, and has a mellow moxa flavor.

(2) Mix the ethanol extracts of Angelica sinensis, Ligusticum chuanxiong, Milla sinensis, frankincense, cinnamon, borneol and Lisianthus in proportion and grind them into fine powder. The mass ratio of the substances is 15:15:15:5:3:0.5:0.03. Pass through a 100-mesh sieve to obtain medicinal powder.

(3) Spray adhesive into the medicinal powder. The mass ratio of medicinal powder to adhesive is 1:1. The adhesive is prepared from hydroxyethyl cellulose and water. The mass concentration is 10% and the preparation temperature is 80°C. , mix evenly to obtain auxiliary materials.

(4) Add the auxiliary materials to the moxa velvet. The mass ratio of moxa velvet to medicated powder is 100:5. Mix it thoroughly and spread it evenly on the moxa velvet paper. Press it into a long strip and dry it at 60°C to reduce the moisture content of the moxa stick to 100:5. Below 5%, moxa sticks are obtained.

Example 7

The difference between Example 7 and Example 1 is that the alcohol extract of Platycodon grandiflorum is also added in step (2).

(1) Choose aged moxa velvet that is earthy or golden in color, soft as cotton, delicate and fluffy, and has a mellow moxa flavor.

(2) Mix the ethanol extracts of Angelica sinensis, Ligusticum chuanxiong, Milla sinensis, frankincense, cinnamon, borneol and Lisianthus in proportion and grind them into fine powder. The mass ratio of the substances is 15:15:15:5:3:0.5:0.05. Pass through a 100-mesh sieve to obtain medicinal powder.

(3) Spray adhesive into the medicinal powder. The mass ratio of medicinal powder to adhesive is 1:1. The adhesive is prepared from hydroxyethyl cellulose and water. The mass concentration is 10% and the preparation temperature is 80°C. , mix evenly to obtain auxiliary materials.

(4) Add the auxiliary materials to the moxa velvet. The mass ratio of moxa velvet to medicated powder is 100:5. Mix it thoroughly and spread it evenly on the moxa velvet paper. Press it into a long strip and dry it at 60°C to reduce the moisture content of the moxa stick to 100:5. Below 5%, moxa sticks are obtained.

Example 8

The difference between Example 8 and Example 1 is that the alcohol extract of Platycodon grandiflorum is also added in step (2).

(1) Choose aged moxa velvet that is earthy or golden in color, soft as cotton, delicate and fluffy, and has a mellow moxa flavor.

(2) Mix the ethanol extracts of Angelica sinensis, Ligusticum chuanxiong, Milla sinensis, frankincense, cinnamon, borneol and Lisianthus in proportion and grind them into fine powder. The mass ratio of the substances is 15:15:15:5:3:0.5:0.1. Pass through a 100-mesh sieve to obtain medicinal powder.

(3) Spray adhesive into the medicinal powder. The mass ratio of medicinal powder to adhesive is 1:1. The adhesive is prepared from hydroxyethyl cellulose and water. The mass concentration is 10% and the preparation temperature is 80°C. , mix evenly to obtain auxiliary materials.

(4) Add the auxiliary materials to the moxa velvet. The mass ratio of moxa velvet to medicated powder is 100:5. Mix it thoroughly and spread it evenly on the moxa velvet paper. Press it into a long strip and dry it at 60°C to reduce the moisture content of the moxa stick to 100:5. Below 5%, moxa sticks are obtained.

Comparative example 1

The difference between Comparative Example 1 and Example 1 is that no medicated powder was added.

Choose aged moxa velvet that is earthy or golden in color, soft as cotton, delicate and fluffy, and has a mellow moxa flavour. Spread it flat on moxa velvet paper, press it into a long strip, and dry it at 60°C to reduce the moisture content of the moxa stick to less than 5%. , get moxa sticks.

Example 9

The difference between Example 9 and Example 1 is that the hydroxyethyl cellulose used in formulating the adhesive is replaced by an equal amount of poloxamer-terminated condensation polymer A.

(1) Choose aged moxa velvet that is earthy or golden in color, soft as cotton, delicate and fluffy, and has a mellow moxa flavor.

(2) Mix Angelica sinensis, Ligusticum chuanxiong, Milla sinensis, frankincense, cinnamon and borneol in proportion and grind them into fine powder. The mass ratio of angelica, chuanxiong, chicken bloodvine, frankincense, cinnamon and borneol is 15:15:15:5. :3:0.5, pass through a 100-mesh sieve to obtain medicinal powder.

(3) Spray the adhesive into the medicinal powder. The mass ratio of the medicinal powder to the adhesive is 1:1. The adhesive is prepared from poloxamer-terminated condensation polymer A adding water. The mass concentration is 10%. The temperature is 80°C, mix evenly, and obtain the auxiliary materials.

(4) Add the auxiliary materials to the moxa velvet. The mass ratio of moxa velvet to medicated powder is 100:5. Mix it thoroughly and spread it evenly on the moxa velvet paper. Press it into a long strip and dry it at 60°C to reduce the moisture content of the moxa stick to 100:5. Below 5%, moxa sticks are obtained.

Randomly select 1,000 patients with varying degrees of chest tightness, shortness of breath, and insufficient Qi and blood symptoms, and randomly divide them into 10 groups, with 100 patients in each group and half of them male and female. Each group will moxibustion moxa sticks prepared in the above embodiments and control examples respectively. , moxibustion was performed on 3 acupoints (Hegu point, Sanyinjiao point, and Xuehai point) every day, each acupoint was moxibustion for 15 minutes, once a day, a course of 7 days, and 4 consecutive courses of moxibustion. The results are shown in Table 1.

Judgment of efficacy:

Cure: All symptoms disappear;

Improvement: Symptoms are significantly reduced;

Not cured: Symptoms have no obvious change.

Table 1

It can be seen from Table 1 that adding the alcohol extract of Platycodon grandiflorum to the medicinal powder when preparing moxa sticks can improve the efficacy of moxibustion, and the use of poloxamer-terminated condensation polymer A (composed of poloxamer and 1,3 -Bis(chloromethyl)-1,1,3,3-tetramethyldisiloxane (made by polycondensation reaction) and the adhesive prepared by adding water will not adversely affect the efficacy of moxibustion.

Comparative example 2

The difference between Comparative Example 2 and Example 9 is that the poloxamer-terminated condensation polymer A used in formulating the adhesive was replaced by an equal amount of poloxamer-terminated condensation polymer B.

(1) Choose aged moxa velvet that is earthy or golden in color, soft as cotton, delicate and fluffy, and has a mellow moxa flavor.

(2) Mix Angelica sinensis, Ligusticum chuanxiong, Milla sinensis, frankincense, cinnamon and borneol in proportion and grind them into fine powder. The mass ratio of angelica, chuanxiong, chicken bloodvine, frankincense, cinnamon and borneol is 15:15:15:5. :3:0.5, pass through a 100-mesh sieve to obtain medicinal powder.

(3) Spray the adhesive into the powder. The mass ratio of the powder to the adhesive is 1:1. The adhesive is prepared from poloxamer-terminated condensation polymer B adding water. The mass concentration is 10%. The temperature is 80°C, mix evenly, and obtain the auxiliary materials.

(4) Add the auxiliary materials to the moxa velvet. The mass ratio of moxa velvet to medicated powder is 100:5. Mix it thoroughly and spread it evenly on the moxa velvet paper. Press it into a long strip and dry it at 60°C to reduce the moisture content of the moxa stick to 100:5. Below 5%, moxa sticks are obtained.

Comparative example 3

The difference between Comparative Example 3 and Example 9 is that the poloxamer-terminated condensation polymer A used in formulating the adhesive was replaced by an equal amount of poloxamer 182.

(1) Choose aged moxa velvet that is earthy or golden in color, soft as cotton, delicate and fluffy, and has a mellow moxa flavor.

(2) Mix Angelica sinensis, Ligusticum chuanxiong, Milla sinensis, frankincense, cinnamon and borneol in proportion and grind them into fine powder. The mass ratio of angelica, chuanxiong, chicken bloodvine, frankincense, cinnamon and borneol is 15:15:15:5. :3:0.5, pass through a 100-mesh sieve to obtain medicinal powder.

(3) Spray the adhesive into the powder. The mass ratio of the powder to the adhesive is 1:1. The adhesive is prepared from poloxamer 182 and water. The mass concentration is 10% and the preparation temperature is 80°C. , mix evenly to obtain auxiliary materials.

(4) Add the auxiliary materials to the moxa velvet. The mass ratio of moxa velvet to medicated powder is 100:5. Mix it thoroughly and spread it evenly on the moxa velvet paper. Press it into a long strip and dry it at 60°C to reduce the moisture content of the moxa stick to 100:5. Below 5%, moxa sticks are obtained.

The adhesive prepared by adding water to the above-mentioned poloxamer-terminated condensation polymer uses its viscosity to act as a bridge between the moxa and the medicinal powder, and improves the adhesion and uniformity of the medicinal powder on the moxa. This requires The poloxamer-terminated condensation polymer for bonding needs to show good viscosity to both moxa and medicated powder. Since the surface physical properties of moxa and medicated powder are completely different, although the adhesive prepared from hydroxyethyl cellulose or poloxamer plus water also has a certain viscosity, it is not enough to make the prescribed amount of medicated powder adhere firmly and evenly. Attached to the moxa velvet, especially after the prepared moxa sticks have been dried and dehydrated, if they are not dried, the moxa sticks will be difficult to burn or burn very slowly due to excessive humidity, causing the moxibustion time to be too long, and at the same time it will Affect the effect of moxibustion.

Select moxa sticks with a length of 100mm prepared in the above embodiments and comparative examples respectively, tear off the outer roll paper, and then place them in a vibrating screen machine equipped with a single-layer screen. The sieving particle size is 0.15mm and the amplitude is 5mm, the vibration frequency is 960r/min, and the amount of material under the sieve is weighed after 5 minutes. Repeat the test three times, take the average value, and calculate the powder loss rate. The results are shown in Table 2. The formula for calculating the powder loss rate is as follows:

Powder loss rate = (mass of substances under sieve/mass of medicinal powder contained in moxa sticks) × 100%

Table 2

Powder loss rate/% Example 1 40.3 Example 2 41.5 Example 3 42.6 Example 4 39.2 Example 5 38.7 Example 9 15.4 Comparative example 2 52.8 Comparative example 3 47.6

As can be seen from Table 2, only the condensation polymer A blocked with poloxamer (composed of poloxamer and 1,3-bis(chloromethyl)-1,1,3,3-tetramethyldisiloxane Only the adhesive prepared by adding water can make the medicinal powder firmly adhere to the moxa velvet.

The basic principles and main features of the present invention and the advantages of the present invention have been shown and described above. Those skilled in the industry should understand that the present invention is not limited by the above embodiments. The above embodiments and descriptions only illustrate the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention will also have other aspects. Various changes and modifications are possible, which fall within the scope of the claimed invention. The scope of protection of the present invention is defined by the appended claims and their equivalents.

Claims (2)

1. A method for preparing moxa sticks with the effect of promoting blood circulation, removing blood stasis and removing dampness, which is characterized in that it includes the following preparation steps: (1) Choose aged moxa velvet that is earthy or golden in color, soft as cotton, delicate and fluffy, and has a mellow moxa flavor; (2) Mix Angelica sinensis, Ligusticum chuanxiong, Milla sinensis, frankincense, cinnamon, and borneol in proportion and grind into fine powder. The mass ratio of angelica, chuanxiong, millipedia, frankincense, cinnamon, and borneol is 15:15:15:5. : 3 : 0.5, pass through a 100-mesh sieve to obtain medicinal powder; (3) Spray the adhesive into the powder. The mass ratio of the powder to the adhesive is 1:1. The adhesive is prepared from poloxamer-terminated condensation polymer A adding water. The mass concentration is 10%. The temperature is 80°C, mix evenly to obtain the auxiliary materials; (4) Add the auxiliary materials to the moxa velvet. The mass ratio of moxa velvet to medicated powder is 100:5. Mix it thoroughly and spread it evenly on the moxa velvet paper. Press it into a long strip and dry it at 60°C to reduce the moisture content of the moxa stick to Below 5%, get moxa stick; The poloxamer-terminated condensation polymer A is made by the polycondensation reaction of poloxamer and 1,3-bis(chloromethyl)-1,1,3,3-tetramethyldisiloxane: Add 0.2 mol of poloxamer 182 and 0.1 mol of 1,3-bis(chloromethyl)-1,1,3,3-tetramethyldisiloxane to tetrahydrofuran, stir and dissolve completely, then add 0.2 mol of triethyl Amine, heat to boiling state and then reflux the reaction. Stop heating after TLC monitors the complete reaction of 1,3-bis(chloromethyl)-1,1,3,3-tetramethyldisiloxane, and cool to room temperature naturally. Wash three times with water at room temperature, filter, dry the filter residue at 80°C, grind into fine powder, and pass through a 100-mesh sieve to obtain poloxamer-terminated condensation polymer A. 2. The moxa stick prepared by the preparation method according to claim 1 and has the effect of activating blood circulation, removing blood stasis and removing dampness.