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CN116898773A - A plant composition with relieving effect - Google Patents

A plant composition with relieving effect Download PDF

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CN116898773A
CN116898773A CN202310965851.9A CN202310965851A CN116898773A CN 116898773 A CN116898773 A CN 116898773A CN 202310965851 A CN202310965851 A CN 202310965851A CN 116898773 A CN116898773 A CN 116898773A
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plant
fermentation
mass
fermentation extract
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韦国裕
林取妹
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Guangzhou Xinsimei Scientific Research Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Biotechnology (AREA)
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  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

本发明涉及护肤品技术领域,提供了一种具有舒缓作用的植物组合物,该植物组合物主要为植物复合发酵提取物,所用的植物原料为以下重量份组分:苦参根6‑8质量份、黄芩1‑3质量份、母菊花3‑5质量份、山金车花1‑3质量份、粉防己3‑6份;所述的组合物无副作用,经皮吸收效性强,能有效舒缓皮肤泛红瘙痒等症状。The invention relates to the technical field of skin care products, and provides a plant composition with a soothing effect. The plant composition is mainly a plant compound fermentation extract, and the plant raw materials used are the following components by weight: Sophora flavescens root 6-8 mass 1-3 parts by mass of Scutellaria baicalensis, 3-5 parts by mass of Matricaria chamomile, 1-3 parts by mass of Arnica flower, and 3-6 parts by mass of Fangfengji; the composition has no side effects, strong transdermal absorption effect, and can Effectively relieves skin redness and itching.

Description

一种具有舒缓作用的植物组合物A soothing plant composition

技术领域Technical field

本发明涉及护肤品技术领域,具体涉及一种具有舒缓作用的植物组合物。The present invention relates to the technical field of skin care products, and in particular to a plant composition with soothing effect.

背景技术Background technique

生活中人们感觉皮肤不适的情况很多,用了不合适的护肤品可能造成皮肤敏感,换季皮肤可能也会敏感,生活习惯不恰当也可能造成皮肤敏感等,当皮肤敏感时最先应该做的就是对皮肤进行舒缓修复,日常维护皮肤稳定也是护肤的关键。在选择护肤品上,应选择有对皮肤进行修复舒缓成分的护肤品,在所有护肤品和洗护用品中应该添加舒缓修复成分,因为在清洁或者美白等功效作用时,起舒缓作用达到保持原有的皮肤稳定状况也同样重要。There are many situations in life where people feel skin discomfort. Using inappropriate skin care products may cause skin sensitivity. Skin may also be sensitive when the seasons change. Improper living habits may also cause skin sensitivity. The first thing you should do when your skin is sensitive is Soothing and repairing the skin and maintaining skin stability daily are also the keys to skin care. When choosing skin care products, you should choose skin care products that have ingredients that repair and soothe the skin. Soothing and repair ingredients should be added to all skin care products and toiletries, because they have a soothing effect to maintain the original appearance when cleaning or whitening. Some skin stability conditions are equally important.

但是很多产品都缺乏有效舒缓成分,当人们在想改善皮肤时,反而让皮肤受到刺激,造成泛红瘙痒肿胀等现象,而且大部分产品添加的为化学成分,并不天然,可能给皮肤造成负担。However, many products lack effective soothing ingredients. When people want to improve their skin, they instead irritate the skin, causing redness, itching, and swelling. Moreover, most products contain chemical ingredients that are not natural and may burden the skin. .

发明内容Contents of the invention

发明目的:本发明目的在于解决现有技术不足,提供一种具有舒缓作用的植物组合物。Purpose of the invention: The purpose of the present invention is to solve the deficiencies of the existing technology and provide a plant composition with a soothing effect.

本发明通过多次试验证明,本发明添加的植物复合发酵提取物能有效缓解皮肤炎症,达到舒缓镇静皮肤的效果,其中添加五重具有舒缓功效的植物原料,并对其进行多重发酵,具有协同递增舒缓功效的作用。The present invention has proven through multiple tests that the plant compound fermentation extract added in the present invention can effectively relieve skin inflammation and achieve the effect of soothing and calming the skin. Five layers of plant raw materials with soothing effects are added to it and subjected to multiple fermentation, which has synergistic effect. Increased soothing effect.

本发明的技术方案如下:The technical solution of the present invention is as follows:

本发明提供一种具有舒缓作用的植物组合物,其特征在于,包含植物复合发酵提取物。The invention provides a plant composition with a soothing effect, which is characterized in that it contains a plant complex fermentation extract.

优选地,所述的植物复合发酵提取物由以下重量份植物原料制备而成:苦参根6-8质量份、黄芩1-3质量份、母菊花3-5质量份、山金车花1-3质量份、粉防己3-6份。Preferably, the plant composite fermentation extract is prepared from the following parts by weight of plant raw materials: 6-8 parts by weight of Sophora flavescens root, 1-3 parts by weight of Scutellaria baicalensis, 3-5 parts by weight of Chamomile flower, and 1 part by weight of Arnica flower. -3 parts by mass, 3-6 parts by mass of Fangji.

优选地,所述的植物复合发酵提取物由以下重量份植物原料制备而成:苦参根7质量份、黄芩2质量份、母菊花4质量份、山金车花2质量份、粉防己5份。Preferably, the plant composite fermentation extract is prepared from the following parts by weight of plant raw materials: 7 parts by weight of Sophora flavescens root, 2 parts by weight of Scutellaria baicalensis, 4 parts by weight of Chamomile flower, 2 parts by weight of Arnica flower, and 5 parts by weight of Radix Fructus. share.

优选地,所述的植物复合发酵提取物的制备方法为:将植物原料加入质量倍数为4-7倍的水进行破碎处理成匀浆,灭菌后放入发酵罐加入复合菌进行有氧发酵提取,发酵温度为27-35°C,发酵时间为14-18天,搅拌速率为150-160rpm,再灭菌,通入二氧化碳和双歧杆菌进行无氧发酵9-13天,再对发酵提取物进行过滤,将过滤液提纯,得到植物复合发酵提取物。Preferably, the preparation method of the plant composite fermentation extract is as follows: add plant raw materials to water with a mass multiple of 4-7 times, crush and process them into homogenates, and after sterilization, put them into a fermentation tank and add composite bacteria for aerobic fermentation. Extraction, the fermentation temperature is 27-35°C, the fermentation time is 14-18 days, the stirring rate is 150-160rpm, then sterilized, carbon dioxide and bifidobacteria are introduced for anaerobic fermentation for 9-13 days, and then the fermentation is extracted The material is filtered, and the filtrate is purified to obtain a plant compound fermentation extract.

优选地,所述的复合菌为酵母菌和木醋杆菌,质量比为1-3:5-8,复合菌的浓度为104-106CFU。Preferably, the composite bacteria are yeast and Acetobacter xylinum, the mass ratio is 1-3:5-8, and the concentration of the composite bacteria is 10 4 -10 6 CFU.

更优选地,所述的提纯的步骤为:将过滤液进行常压蒸馏1-2h,反应温度为60-70°C,再减压蒸馏2-4h,控制反应压力为-0.01-0MPa、反应温度为35.5-59.9°C。More preferably, the purification step is: distill the filtrate under normal pressure for 1-2h, the reaction temperature is 60-70°C, and then distill under reduced pressure for 2-4h, and control the reaction pressure to -0.01-0MPa. The temperature is 35.5-59.9°C.

优选地,所述的一种具有舒缓作用的植物组合物在护肤品中的应用。Preferably, the plant composition with soothing effect is used in skin care products.

有益效果:本发明制备得到的组合物无副作用,经皮吸收效性强,能有效舒缓皮肤泛红瘙痒等症状。Beneficial effects: The composition prepared by the present invention has no side effects, has strong transdermal absorption effect, and can effectively relieve symptoms such as skin redness and itching.

具体实施方式Detailed ways

下面以具体实施例对本发明进行说明,特此申明,此处所选实施例仅用于说明和解释本发明,并不用于限定本发明。 The present invention will be described below with specific embodiments. It is hereby stated that the embodiments selected here are only used to illustrate and explain the present invention and are not intended to limit the present invention.

实施例1Example 1

本实施例提供一种具有舒缓作用的植物组合物,所述的植物组合物为植物复合发酵提取物。This embodiment provides a plant composition with a soothing effect, and the plant composition is a plant complex fermentation extract.

所述的植物复合发酵提取物由以下重量份植物原料制备而成:苦参根7质量份、黄芩2质量份、母菊花4质量份、山金车花2质量份、粉防己5份。The plant composite fermentation extract is prepared from the following plant raw materials in parts by weight: 7 parts by mass of Sophora flavescens root, 2 parts by mass of Scutellaria baicalensis, 4 parts by mass of Chamomile flower, 2 parts by mass of Arnica flower, and 5 parts by mass of Radix Fructus.

所述的植物复合发酵提取物的制备方法为:将植物原料加入质量倍数为6倍的水进行破碎处理成匀浆,灭菌后放入发酵罐加入复合菌进行有氧发酵提取,发酵温度为31°C,发酵时间为16天,搅拌速率为155rpm,再灭菌,通入二氧化碳和双歧杆菌进行无氧发酵11天,再对发酵提取物进行过滤,将过滤液提纯,得到植物复合发酵提取物。The preparation method of the plant compound fermentation extract is as follows: add plant raw materials to water with a mass multiple of 6 times, crush and process it into a homogenate, put it into a fermentation tank after sterilization, add compound bacteria for aerobic fermentation extraction, and the fermentation temperature is 31°C, the fermentation time is 16 days, the stirring rate is 155rpm, then sterilize, introduce carbon dioxide and bifidobacteria for anaerobic fermentation for 11 days, then filter the fermentation extract, purify the filtrate, and obtain plant compound fermentation Extract.

所述的复合菌为酵母菌和木醋杆菌,质量比为2:7,复合菌的浓度为105CFU。The composite bacteria are yeast and Acetobacter xylinum, the mass ratio is 2:7, and the concentration of the composite bacteria is 10 5 CFU.

所述的提纯的步骤为:将过滤液进行常压蒸馏1h,反应温度为65°C,再减压蒸馏3h,控制反应压力为-0.05MPa、反应温度为40°C。 The purification steps are: distill the filtrate under normal pressure for 1 hour, the reaction temperature is 65°C, and then distill under reduced pressure for 3 hours, controlling the reaction pressure to -0.05MPa and the reaction temperature to 40°C.

实施例2Example 2

本实施例提供一种具有舒缓作用的植物组合物,所述的植物组合物为植物复合发酵提取物。This embodiment provides a plant composition with a soothing effect, and the plant composition is a plant complex fermentation extract.

所述的植物复合发酵提取物由以下重量份植物原料制备而成:苦参根6质量份、黄芩1质量份、母菊花3质量份、山金车花1质量份、粉防己3份。The plant composite fermentation extract is prepared from the following plant raw materials in parts by weight: 6 parts by mass of Sophora flavescens root, 1 part by mass of Scutellaria baicalensis, 3 parts by mass of Chamomile flower, 1 part by mass of Arnica flower, and 3 parts by mass of Fangjie root.

所述的植物复合发酵提取物的制备方法为:将植物原料加入质量倍数为4倍的水进行破碎处理成匀浆,灭菌后放入发酵罐加入复合菌进行有氧发酵提取,发酵温度为27°C,发酵时间为14天,搅拌速率为150rpm,再灭菌,通入二氧化碳和双歧杆菌进行无氧发酵9天,再对发酵提取物进行过滤,将过滤液提纯,得到植物复合发酵提取物。The preparation method of the plant composite fermentation extract is as follows: add plant raw materials to water with a mass multiple of 4 times, crush and process it into a homogenate, put it into a fermentation tank after sterilization, add composite bacteria for aerobic fermentation extraction, and the fermentation temperature is 27°C, the fermentation time is 14 days, the stirring rate is 150rpm, then sterilize, introduce carbon dioxide and bifidobacteria for anaerobic fermentation for 9 days, then filter the fermentation extract, purify the filtrate, and obtain plant compound fermentation Extract.

所述的复合菌为酵母菌和木醋杆菌,质量比为1:5,复合菌的浓度为104CFU。The composite bacteria are yeast and Acetobacter xylinum, the mass ratio is 1:5, and the concentration of the composite bacteria is 10 4 CFU.

所述的提纯的步骤为:将过滤液进行常压蒸馏1h,反应温度为60°C,再减压蒸馏2h,控制反应压力为-0.01MPa、反应温度为35.5°C。 The purification steps are: distill the filtrate under normal pressure for 1 hour, the reaction temperature is 60°C, and then distill under reduced pressure for 2 hours, controlling the reaction pressure to -0.01MPa and the reaction temperature to 35.5°C.

实施例3Example 3

本实施例提供一种具有舒缓作用的植物组合物,所述的植物组合物为植物复合发酵提取物。This embodiment provides a plant composition with a soothing effect, and the plant composition is a plant complex fermentation extract.

所述的植物复合发酵提取物由以下重量份植物原料制备而成:苦参根8质量份、黄芩3质量份、母菊花5质量份、山金车花3质量份、粉防己6份。The plant composite fermentation extract is prepared from the following plant raw materials in parts by weight: 8 parts by mass of Sophora flavescens root, 3 parts by mass of Scutellaria baicalensis, 5 parts by mass of Chamomile flower, 3 parts by mass of Arnica flower, and 6 parts by mass of Radix Fructus.

所述的植物复合发酵提取物的制备方法为:将植物原料加入质量倍数为7倍的水进行破碎处理成匀浆,灭菌后放入发酵罐加入复合菌进行有氧发酵提取,发酵温度为35°C,发酵时间为18天,搅拌速率为160rpm,再灭菌,通入二氧化碳和双歧杆菌进行无氧发酵13天,再对发酵提取物进行过滤,将过滤液提纯,得到植物复合发酵提取物。The preparation method of the plant compound fermentation extract is as follows: add plant raw materials to water with a mass multiple of 7 times, crush and process it into a homogenate, put it into a fermentation tank after sterilization, add compound bacteria for aerobic fermentation extraction, and the fermentation temperature is 35°C, the fermentation time is 18 days, the stirring rate is 160rpm, then sterilize, introduce carbon dioxide and bifidobacteria for anaerobic fermentation for 13 days, then filter the fermentation extract, purify the filtrate, and obtain plant compound fermentation Extract.

所述的复合菌为酵母菌和木醋杆菌,质量比为3:8,复合菌的浓度为106CFU。The composite bacteria are yeast and Acetobacter xylinum, the mass ratio is 3:8, and the concentration of the composite bacteria is 10 6 CFU.

所述的提纯的步骤为:将过滤液进行常压蒸馏2h,反应温度为70°C,再减压蒸馏4h,控制反应压力为-0.2MPa、反应温度为45.5°C。 The purification steps include: distilling the filtrate under normal pressure for 2 hours, with a reaction temperature of 70°C, and then distilling under reduced pressure for 4 hours, controlling the reaction pressure to -0.2MPa and the reaction temperature to 45.5°C.

对比例1Comparative example 1

对比例1与实施例1的不同之处在于,对比例1的植物复合发酵提取物中的植物原料不添加意大利蜡菊。The difference between Comparative Example 1 and Example 1 is that the plant raw materials in the plant composite fermentation extract of Comparative Example 1 do not add Helichrysum italia.

对比例2Comparative example 2

对比例2与实施例1的不同之处在于,对比例2的植物复合发酵提取物中的植物原料不添加粉防己。The difference between Comparative Example 2 and Example 1 is that the plant raw materials in the plant composite fermentation extract of Comparative Example 2 do not add tetragaloside.

对比例3Comparative example 3

对比例3与实施例1的不同之处在于,对比例3的植物复合发酵提取物的发酵方法不同,发酵方法为:将植物原料加入质量倍数为6倍的水进行破碎处理成匀浆,灭菌后放入发酵罐加入复合菌进行有氧发酵提取,发酵温度为31°C,发酵时间为16天,搅拌速率为155rpm再对发酵提取物进行过滤得到植物复合发酵提取物。The difference between Comparative Example 3 and Example 1 is that the fermentation method of the plant compound fermentation extract of Comparative Example 3 is different. The fermentation method is: add the plant raw materials to water with a mass multiple of 6 times, crush it into a homogenate, and sterilize it. After the bacteria are put into the fermentation tank, compound bacteria are added to perform aerobic fermentation extraction. The fermentation temperature is 31°C, the fermentation time is 16 days, the stirring rate is 155rpm, and the fermentation extract is filtered to obtain a plant compound fermentation extract.

所述的复合菌为酵母菌和木醋杆菌,质量比为2:7,复合菌的浓度为105CFU。The composite bacteria are yeast and Acetobacter xylinum, the mass ratio is 2:7, and the concentration of the composite bacteria is 10 5 CFU.

功效验证Efficacy verification

准备50只实验大鼠,分成10组,在每只实验大鼠的耳廓处涂抹二甲苯,使大鼠的耳廓产生过敏肿胀现象,再用实施例和对比例制备得到的产品分别对大鼠耳廓进行涂抹,用生理盐水做空白对照,之后每6h进行复涂一次,24h后处死大鼠,用7mm的打孔器取下大鼠的耳片,放在天平上称量,用左耳的耳片进行对照,得到大鼠的耳廓肿胀率(%),对实验结果进行记录,记录结果如表1所示。Prepare 50 experimental rats and divide them into 10 groups. Apply xylene to the auricles of each experimental rat to cause allergic swelling in the auricles of the rats. Then use the products prepared in the Examples and Comparative Examples to treat the rats respectively. The rat auricle was smeared, and normal saline was used as a blank control, and then re-coated every 6 hours. The rats were killed after 24 hours, and the ear pieces of the rats were removed with a 7mm puncher, weighed on a balance, and weighed with the left The ear pieces of the ear were compared to obtain the auricular swelling rate (%) of the rat, and the experimental results were recorded. The recorded results are shown in Table 1.

表1Table 1

由表1试验结果可知,本发明制备得到的组合物具有有效的抗敏舒缓效果,作用快,在24h的时间里对过敏皮肤进行修复,消肿镇静效果显著;It can be seen from the test results in Table 1 that the composition prepared by the present invention has an effective anti-allergic and soothing effect, acts quickly, repairs allergic skin within 24 hours, and has a significant swelling and sedation effect;

由对比例1-3可知,本发明的植物复合发酵提取物采用多重植物原料进行复合发酵提纯,比缺少其中某一原料,以及采用其他发酵方法,舒缓效果更为显著;It can be seen from Comparative Examples 1-3 that the plant compound fermentation extract of the present invention uses multiple plant raw materials for compound fermentation and purification. Compared with the absence of one of the raw materials and the use of other fermentation methods, the soothing effect is more significant;

最后所应当说明的是,以上实施例仅用于说明本发明的技术方案而非对本发明保护范围进行限制,尽管参照较佳实施例对本发明作了详细说明,本领域的普通技术人员应当理解,可以对本发明的技术方案进行修改或者等同替换,而不脱离本发明技术方案的实质和范围。Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and do not limit the protection scope of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art will understand that The technical solution of the present invention may be modified or equivalently substituted without departing from the essence and scope of the technical solution of the present invention.

Claims (7)

1. A plant composition with soothing effect, characterized by comprising a plant complex fermentation extract.
2. The plant composition with relieving effect according to claim 1, wherein the plant composite fermentation extract is prepared from the following plant raw materials in parts by weight: 6-8 parts of kuh-seng root, 1-3 parts of baikal skullcap root, 3-5 parts of mother chrysanthemum, 1-3 parts of arnica and 3-6 parts of tetrandra root.
3. The plant composition with relieving effect according to claim 1, wherein the plant composite fermentation extract is prepared from the following plant raw materials in parts by weight: 7 parts of kuh-seng root, 2 parts of baical skullcap root, 4 parts of mother chrysanthemum, 2 parts of arnica and 5 parts of tetrandra root.
4. The plant composition with soothing function according to claim 1, wherein the preparation method of the plant composite fermentation extract comprises the following steps: adding water with the mass multiple of 4-7 times into plant raw materials, crushing into homogenate, sterilizing, putting into a fermentation tank, adding compound bacteria, performing aerobic fermentation and extraction, wherein the fermentation temperature is 27-35 ℃, the fermentation time is 14-18 days, the stirring speed is 150-160rpm, sterilizing, introducing carbon dioxide and bifidobacterium, performing anaerobic fermentation for 9-13 days, filtering the fermentation extract, and purifying filtrate to obtain the plant compound fermentation extract.
5. The plant composition with relieving effect according to claim 4, wherein the composite bacteria are saccharomycetes and acetobacter xylinum, the mass ratio is 1-3:5-8, and the concentration of the composite bacteria is 10 4 -10 6 CFU。
6. The plant composition with soothing function according to claim 4, wherein the purification step comprises: distilling the filtrate under normal pressure for 1-2h at 60-70deg.C, and distilling under reduced pressure for 2-4h under-0.01-0 MPa at 35.5-59.9deg.C.
7. Use of a phytochemical with soothing action according to any one of claims 1 to 6 in skin care products.
CN202310965851.9A 2023-08-02 2023-08-02 A plant composition with relieving effect Pending CN116898773A (en)

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