CN116747158B - Cosmetic composition capable of resisting wrinkle and compacting through mitochondria and application thereof - Google Patents
Cosmetic composition capable of resisting wrinkle and compacting through mitochondria and application thereof Download PDFInfo
- Publication number
- CN116747158B CN116747158B CN202310955491.4A CN202310955491A CN116747158B CN 116747158 B CN116747158 B CN 116747158B CN 202310955491 A CN202310955491 A CN 202310955491A CN 116747158 B CN116747158 B CN 116747158B
- Authority
- CN
- China
- Prior art keywords
- extract
- cosmetic
- undaria pinnatifida
- skin
- cosmetic composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 86
- 239000000203 mixture Substances 0.000 title claims abstract description 49
- 210000003470 mitochondria Anatomy 0.000 title abstract description 21
- 230000037303 wrinkles Effects 0.000 title abstract description 7
- 241001261506 Undaria pinnatifida Species 0.000 claims abstract description 52
- NDVRKEKNSBMTAX-MVNLRXSJSA-N (2s,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O NDVRKEKNSBMTAX-MVNLRXSJSA-N 0.000 claims abstract description 27
- 239000011734 sodium Substances 0.000 claims abstract description 27
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 27
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 25
- 241001467355 Gigartina Species 0.000 claims abstract description 24
- 241001090156 Huperzia serrata Species 0.000 claims abstract description 14
- 239000006071 cream Substances 0.000 claims description 29
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 28
- 238000002360 preparation method Methods 0.000 claims description 27
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 20
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 20
- 230000001153 anti-wrinkle effect Effects 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- -1 polydimethylsiloxane Polymers 0.000 claims description 11
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 10
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 10
- 239000004475 Arginine Substances 0.000 claims description 10
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 10
- 229920002125 Sokalan® Polymers 0.000 claims description 10
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 10
- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 10
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 10
- 229930182478 glucoside Natural products 0.000 claims description 10
- 150000008131 glucosides Chemical class 0.000 claims description 10
- 235000011187 glycerol Nutrition 0.000 claims description 10
- 229920006007 hydrogenated polyisobutylene Polymers 0.000 claims description 10
- 239000000787 lecithin Substances 0.000 claims description 10
- 235000010445 lecithin Nutrition 0.000 claims description 10
- 229940067606 lecithin Drugs 0.000 claims description 10
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 10
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 10
- 229940101267 panthenol Drugs 0.000 claims description 10
- 235000020957 pantothenol Nutrition 0.000 claims description 10
- 239000011619 pantothenol Substances 0.000 claims description 10
- 229960005323 phenoxyethanol Drugs 0.000 claims description 10
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 10
- 229940032094 squalane Drugs 0.000 claims description 10
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 10
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 9
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 9
- 241000221095 Simmondsia Species 0.000 claims description 9
- 235000004433 Simmondsia californica Nutrition 0.000 claims description 9
- 229960001631 carbomer Drugs 0.000 claims description 9
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 9
- OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 claims description 8
- 238000009472 formulation Methods 0.000 claims description 7
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 6
- 241000218642 Abies Species 0.000 claims description 6
- 239000000686 essence Substances 0.000 claims description 6
- 241000195493 Cryptophyta Species 0.000 claims description 4
- 230000001815 facial effect Effects 0.000 claims description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 4
- 239000003921 oil Substances 0.000 claims description 4
- 235000019198 oils Nutrition 0.000 claims description 4
- 241000284156 Clerodendrum quadriloculare Species 0.000 claims description 3
- 235000018330 Macadamia integrifolia Nutrition 0.000 claims description 3
- 240000000912 Macadamia tetraphylla Species 0.000 claims description 3
- 235000003800 Macadamia tetraphylla Nutrition 0.000 claims description 3
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 3
- 239000002738 chelating agent Substances 0.000 claims description 3
- 239000003974 emollient agent Substances 0.000 claims description 3
- 239000003995 emulsifying agent Substances 0.000 claims description 3
- 239000003906 humectant Substances 0.000 claims description 3
- 239000010466 nut oil Substances 0.000 claims description 3
- 239000003755 preservative agent Substances 0.000 claims description 3
- 230000002335 preservative effect Effects 0.000 claims description 3
- 239000002562 thickening agent Substances 0.000 claims description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 2
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical group OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 2
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims description 2
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 2
- 229940075529 glyceryl stearate Drugs 0.000 claims description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 2
- 229960002216 methylparaben Drugs 0.000 claims description 2
- 239000002480 mineral oil Substances 0.000 claims description 2
- 235000010446 mineral oil Nutrition 0.000 claims description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 2
- 235000010241 potassium sorbate Nutrition 0.000 claims description 2
- 239000004302 potassium sorbate Substances 0.000 claims description 2
- 229940069338 potassium sorbate Drugs 0.000 claims description 2
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 229960005150 glycerol Drugs 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 239000001488 sodium phosphate Substances 0.000 claims 1
- 229910000162 sodium phosphate Inorganic materials 0.000 claims 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 abstract description 9
- 102000008186 Collagen Human genes 0.000 abstract description 9
- 229920001436 collagen Polymers 0.000 abstract description 9
- 230000004060 metabolic process Effects 0.000 abstract description 8
- 230000015572 biosynthetic process Effects 0.000 abstract description 5
- 238000003786 synthesis reaction Methods 0.000 abstract description 5
- 230000001413 cellular effect Effects 0.000 abstract description 2
- 230000036560 skin regeneration Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 48
- 238000012360 testing method Methods 0.000 description 41
- 230000000694 effects Effects 0.000 description 28
- 230000000052 comparative effect Effects 0.000 description 21
- 239000000047 product Substances 0.000 description 16
- 210000004027 cell Anatomy 0.000 description 13
- 150000003254 radicals Chemical class 0.000 description 13
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 9
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 9
- 206010013786 Dry skin Diseases 0.000 description 9
- 230000001976 improved effect Effects 0.000 description 9
- 241000251468 Actinopterygii Species 0.000 description 8
- 230000003078 antioxidant effect Effects 0.000 description 8
- 239000004480 active ingredient Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 239000003642 reactive oxygen metabolite Substances 0.000 description 7
- 230000002000 scavenging effect Effects 0.000 description 7
- 230000032683 aging Effects 0.000 description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 6
- 230000003647 oxidation Effects 0.000 description 6
- 238000007254 oxidation reaction Methods 0.000 description 6
- 239000001301 oxygen Substances 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- 230000006378 damage Effects 0.000 description 5
- 210000004207 dermis Anatomy 0.000 description 5
- 230000034659 glycolysis Effects 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 210000004927 skin cell Anatomy 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 241000252212 Danio rerio Species 0.000 description 4
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 4
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 description 4
- 230000003064 anti-oxidating effect Effects 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 4
- 230000001965 increasing effect Effects 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 230000002438 mitochondrial effect Effects 0.000 description 4
- 230000037393 skin firmness Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 229940006284 undaria pinnatifida extract Drugs 0.000 description 4
- 210000001325 yolk sac Anatomy 0.000 description 4
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 3
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 3
- 241001504070 Huperzia Species 0.000 description 3
- 108020005196 Mitochondrial DNA Proteins 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000003712 anti-aging effect Effects 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 230000032677 cell aging Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000001804 emulsifying effect Effects 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 210000002744 extracellular matrix Anatomy 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000014509 gene expression Effects 0.000 description 3
- NUHSROFQTUXZQQ-UHFFFAOYSA-N isopentenyl diphosphate Chemical compound CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 230000000241 respiratory effect Effects 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- 229940041603 vitamin k 3 Drugs 0.000 description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 2
- HYPYXGZDOYTYDR-HAJWAVTHSA-N 2-methyl-3-[(2e,6e,10e,14e)-3,7,11,15,19-pentamethylicosa-2,6,10,14,18-pentaenyl]naphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 HYPYXGZDOYTYDR-HAJWAVTHSA-N 0.000 description 2
- 102000009836 Aconitate hydratase Human genes 0.000 description 2
- 108010009924 Aconitate hydratase Proteins 0.000 description 2
- 102100040958 Aconitate hydratase, mitochondrial Human genes 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 102000016942 Elastin Human genes 0.000 description 2
- 108010014258 Elastin Proteins 0.000 description 2
- 101000965314 Homo sapiens Aconitate hydratase, mitochondrial Proteins 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 2
- MJVAVZPDRWSRRC-UHFFFAOYSA-N Menadione Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 description 2
- 206010040914 Skin reaction Diseases 0.000 description 2
- 230000006838 adverse reaction Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 230000019522 cellular metabolic process Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000005056 compaction Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 2
- 210000004177 elastic tissue Anatomy 0.000 description 2
- 229920002549 elastin Polymers 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 230000007760 free radical scavenging Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 229920002674 hyaluronan Polymers 0.000 description 2
- 229960003160 hyaluronic acid Drugs 0.000 description 2
- 230000007954 hypoxia Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 2
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 2
- 230000010627 oxidative phosphorylation Effects 0.000 description 2
- 230000036542 oxidative stress Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 229940107700 pyruvic acid Drugs 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000009759 skin aging Effects 0.000 description 2
- 230000035483 skin reaction Effects 0.000 description 2
- 231100000430 skin reaction Toxicity 0.000 description 2
- 230000035882 stress Effects 0.000 description 2
- 230000004102 tricarboxylic acid cycle Effects 0.000 description 2
- 150000003627 tricarboxylic acid derivatives Chemical class 0.000 description 2
- 235000019143 vitamin K2 Nutrition 0.000 description 2
- 239000011728 vitamin K2 Substances 0.000 description 2
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- QWGRWMMWNDWRQN-UHFFFAOYSA-N 2-methylpropane-1,3-diol Chemical compound OCC(C)CO QWGRWMMWNDWRQN-UHFFFAOYSA-N 0.000 description 1
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 description 1
- 230000002407 ATP formation Effects 0.000 description 1
- NBSCHQHZLSJFNQ-QTVWNMPRSA-N D-Mannose-6-phosphate Chemical compound OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]1O NBSCHQHZLSJFNQ-QTVWNMPRSA-N 0.000 description 1
- 230000033616 DNA repair Effects 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000195480 Fucus Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102100032742 Histone-lysine N-methyltransferase SETD2 Human genes 0.000 description 1
- 101000654725 Homo sapiens Histone-lysine N-methyltransferase SETD2 Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 1
- 230000002292 Radical scavenging effect Effects 0.000 description 1
- 206010050637 Skin tightness Diseases 0.000 description 1
- 208000010340 Sleep Deprivation Diseases 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical class [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- 108010031318 Vitronectin Proteins 0.000 description 1
- 102100035140 Vitronectin Human genes 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000008649 adaptation response Effects 0.000 description 1
- TTWYZDPBDWHJOR-IDIVVRGQSA-L adenosine triphosphate disodium Chemical compound [Na+].[Na+].C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O TTWYZDPBDWHJOR-IDIVVRGQSA-L 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000004103 aerobic respiration Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 230000010001 cellular homeostasis Effects 0.000 description 1
- 230000005754 cellular signaling Effects 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- MGJZITXUQXWAKY-UHFFFAOYSA-N diphenyl-(2,4,6-trinitrophenyl)iminoazanium Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1N=[N+](C=1C=CC=CC=1)C1=CC=CC=C1 MGJZITXUQXWAKY-UHFFFAOYSA-N 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 229940100524 ethylhexylglycerin Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 229940118127 fucus vesiculosus extract Drugs 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000006882 induction of apoptosis Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 229940100573 methylpropanediol Drugs 0.000 description 1
- 230000004065 mitochondrial dysfunction Effects 0.000 description 1
- 230000004898 mitochondrial function Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 230000008557 oxygen metabolism Effects 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 229940076788 pyruvate Drugs 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000025053 regulation of cell proliferation Effects 0.000 description 1
- 230000035806 respiratory chain Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 238000011076 safety test Methods 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 230000004215 skin function Effects 0.000 description 1
- 230000036558 skin tension Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 235000012711 vitamin K3 Nutrition 0.000 description 1
- 239000011652 vitamin K3 Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9717—Rhodophycota or Rhodophyta [red algae], e.g. Porphyra
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the technical field of cosmetics, and particularly relates to a cosmetic composition capable of resisting wrinkle and compacting through mitochondria and application thereof. The cosmetic composition comprises sodium mannose phosphate, a huperzia serrata (GIGARTINA STELLATA) extract and a undaria pinnatifida (Undaria Pinnatifida) extract, wherein the weight ratio of the sodium mannose phosphate is as follows: extract of huperzia serrata (GIGARTINA STELLATA): undaria pinnatifida (Undaria Pinnatifida) extract= (1-50): (1-50): (1-50). Research results show that the cosmetic composition provided by the invention can remove free radicals for aged skin, promote metabolism, promote collagen synthesis, accelerate skin regeneration, improve skin toughness from a cellular energy level, and enable the skin to be tough, smooth, elastic, compact and full, and thin and fade.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a cosmetic composition capable of resisting wrinkle and compacting through mitochondria and application thereof. The invention particularly relates to a cosmetic composition with the functions of optimizing skin energy regulation, establishing an autonomous anti-aging barrier of skin, improving youthful texture of skin and improving overall skin state and application thereof.
Background
Skin cells require energy to cope with external environmental pressure and repair skin damage, such as collagen synthesis in skin, DNA repair, regulation of cell proliferation, activation of apoptosis, etc., all of which require energy consumption.
About 95% of the energy required for vital cell activity is produced in the mitochondria within the cell. Mitochondria are used as an energy factory of cells, and nutrient substances are converted into chemical energy Adenosine Triphosphate (ATP) required for driving cell metabolism mainly through three stages of glycolysis, pyruvic acid circulation, tricarboxylic acid circulation and oxidative phosphorylation by aerobic respiration, and meanwhile, the growth and apoptosis of the cells are regulated and controlled.
Skin aging is triggered by internal and external factors, the accumulation of external pressure and internal dysfunction (such as cell aging, insufficient sleep, physiological pressure, external environment injury and the like caused by aging) changes the bioenergy circulation mechanism of skin cells, aggravates the loss of skin functions, and simultaneously affects the reduction of mitochondrial functions, so that ATP (adenosine triphosphate) produced by mitochondria is reduced, skin metabolism is reduced, and the 'electric power' required by collagen synthesis and damage repair of skin cells is insufficient; meanwhile, more Reactive Oxygen Species (ROS) and fewer endogenous antioxidants are generated in the process of generating ATP by mitochondria, so that unbalance of free radical metabolic capacity occurs, thereby increasing damage of mitochondrial DNA and further aggravating mitochondrial dysfunction. Cell aging is a core driving force for individual aging, and many studies in academia show that mitochondria are important triggers for cell aging, and accumulated damage of the mitochondria accelerates skin aging in the long term, so that skin loses the resistance and self-regulating adaptation stress which are needed by the skin, elasticity is reduced, tightness is lost, pigmentation, wrinkles and relaxation problems are more obvious, and obvious fatigue and aging signs appear.
The skin care agent acts on mitochondria of a cell energy station, is beneficial to restoring skin activity and solves the deep anti-aging problem. In view of this, the present invention provides a cosmetic composition for anti-wrinkle tightening through mitochondria.
Disclosure of Invention
In order to solve the technical problems and fill the blank in the prior art, the invention provides a cosmetic composition for anti-wrinkle and tightening through mitochondria and application thereof. The invention particularly provides a cosmetic composition with the functions of optimizing skin energy regulation, establishing an autonomous anti-aging barrier of skin, improving youthful texture of skin and improving the overall skin state and application thereof.
Specifically, the invention is realized through the following technical schemes:
in a first aspect, the present invention provides a cosmetic composition for anti-wrinkle compaction by mitochondria, comprising sodium mannose phosphate, an extract of huperzia serrata (GIGARTINA STELLATA) and an extract of undaria pinnatifida (Undaria Pinnatifida), wherein the sodium mannose phosphate is in weight ratio: extract of huperzia serrata (GIGARTINA STELLATA): undaria pinnatifida (Undaria Pinnatifida) extract= (1-50): (1-50): (1-50).
Alternatively, in the above cosmetic composition, the sodium mannose phosphate is: extract of huperzia serrata (GIGARTINA STELLATA): undaria pinnatifida (Undaria Pinnatifida) extract= (1-20): (1-20): (1-20).
Alternatively, in the above cosmetic composition, the sodium mannose phosphate is: extract of huperzia serrata (GIGARTINA STELLATA): undaria pinnatifida (Undaria Pinnatifida) extract= (1-5): (1-5): (1-5).
Alternatively, in the above cosmetic composition, the sodium mannose phosphate is: extract of huperzia serrata (GIGARTINA STELLATA): undaria pinnatifida (Undaria Pinnatifida) extract = 1:1:1.
alternatively, in the above cosmetic composition, the cosmetic composition is made of sodium mannose phosphate, a huperzia serrata (GIGARTINA STELLATA) extract, and a undaria pinnatifida (Undaria Pinnatifida) extract.
The cosmetic composition used in the cosmetic composition of the present invention is commercially available as a raw material for cosmetics from sodium mannose phosphate, extract of Abies stargarcinia (GIGARTINA STELLATA) and extract of Undaria pinnatifida (Undaria Pinnatifida).
Alternatively, in the above cosmetic composition, the cosmetic composition of the present invention is a cosmetic composition having a trade name of Decipiens AGE-Shine TM Is a product of (a).
In a second aspect, the present invention provides a cosmetic preparation for anti-wrinkle compaction by mitochondria, comprising the cosmetic composition according to the first aspect above and adjuvants conventional in the cosmetic field.
Alternatively, in the above cosmetic preparation, the cosmetic preparation is selected from a toner, an emulsion, an essence, a cream or a mask.
Alternatively, in the above cosmetic preparation, the cosmetic preparation comprises the following components in weight percent:
alternatively, in the above cosmetic preparation, the cosmetic preparation comprises the following components in weight percent:
alternatively, in the above cosmetic preparation, the humectant is selected from any one or a combination of two or more of methyl propylene glycol, 1, 3-butylene glycol, glycerin polyether-26, and panthenol.
Alternatively, in the above cosmetic preparation, the preservative is selected from any one or a combination of two or more of methyl ester, phenoxyethanol, potassium sorbate, ethylhexyl glycerol, methylparaben, and ethylparaben.
Alternatively, in the above cosmetic preparation, the chelating agent pack is selected from EDTA-2NA and/or p-hydroxyacetophenone.
Alternatively, in the above cosmetic formulation, the thickener is selected from carbomers and/or cetostearyl alcohol.
Alternatively, in the above cosmetic preparation, the pH adjuster is selected from triethanolamine and/or arginine.
Alternatively, in the above cosmetic preparation, the emulsifier is selected from any one or a combination of two or more of cetostearyl glucoside, lecithin, PEG-40, stearate or glyceryl stearate.
Alternatively, in the above cosmetic preparation, the emollient is selected from any one or a combination of two or more of macadamia nut oil, hydrogenated vegetable-derived oil, squalane, jojoba seed oil, hydrogenated polyisobutene, white mineral oil, and polydimethylsiloxane.
The cosmetic composition according to the first aspect may be formulated into any dosage form in the cosmetic field by a person skilled in the cosmetic field using a preparation method well known in the cosmetic field.
In a third aspect, the present invention provides the use of a cosmetic composition as described in the first aspect or a cosmetic preparation as described in the second aspect above for the preparation of a cosmetic having anti-wrinkle tightening efficacy.
It is understood that within the scope of the present invention, the above-described technical features of the present invention and technical features specifically described below (e.g., in the examples) may be combined with each other to constitute new or preferred technical solutions. Is limited to a space and will not be described in detail herein.
Compared with the prior art, the invention has the following beneficial effects:
(1) The three active ingredients of sodium mannose phosphate, the extract of the huperzia serrata (GIGARTINA STELLATA) and the extract of the undaria pinnatifida (Undaria Pinnatifida) in the cosmetic composition can respectively act on different stages of ATP aerobic respiratory chain generated by mitochondria, so that the three ingredients can play a synergistic effect.
(2) Aiming at links and metabolic mechanisms of skin cell energy production, the cosmetic composition takes mitochondria maintenance as a core thought, strengthens the capacity of autonomously producing energy of skin by effectively increasing mitochondrial activity and improving cell energy molecule ATP generation, establishes an self-anti-aging barrier of skin, autonomously repairs and resists aging, eliminates free radicals for aged skin, promotes metabolism, promotes collagen synthesis, accelerates skin renewal speed, improves the toughness of skin from a cell energy level, and makes the skin tough, smooth, elastic, compact and full, and thin lines fade.
Drawings
Fig. 1: typical pattern of antioxidant efficacy of the cosmetic compositions of the present invention. Wherein the yellow dotted line part is a quantitative region.
Detailed Description
In order to better understand the present invention, the action mechanism of the cosmetic composition of the present invention by mitochondrial wrinkle resistance and the action of the main active ingredient in the cosmetic composition of the present invention are further explained below.
Mitochondrial production ATP aerobic respiratory link corresponds to component mechanism:
the main energy supply material in the human body is sugar, and the way in which ATP energy is generated by decomposing sugar by the human body: aerobic oxidation and anaerobic oxidation, wherein aerobic oxidation is the primary energy supply.
The process of generating energy by aerobic oxidation is divided into three stages:
1. the first stage, glycolysis;
2. the second phase, pyruvate enters the mitochondria, producing acetyl CoA;
3. the third stage, acetyl CoA, is energized by tricarboxylic acid cycle and oxidative phosphorylation.
(II) the action of the main active ingredients in the cosmetic composition of the present invention:
the cosmetic composition of the invention is effective for stimulating mitochondrial energy circulation, increasing energy reserve in skin, promoting cell metabolism and renewal, and providing skin cells with more energy to resist stimulation of the surrounding environment.
1. Glycolysis-sodium mannose phosphate
The production of cellular energy requires carbohydrates, and glucose is decomposed in the cytoplasm by glycolysis to produce pyruvic acid and NADH during glycolysis, producing energy ATP. NADH produced by this process enters the mitochondria to participate in subsequent reactions to continue ATP production.
The mannose phosphate sodium feeds mannose-6-phosphate complex into cells for glycolysis, so that protein saccharification can not be caused, the activity of ATP synthase in aged cells can be increased by 3 times, and the metabolism of the cells can be promoted; and stimulates the expression of various proteins involved in the dermis structure, significantly increases the density of the dermis reticular layer, and sodium mannose phosphate has the effect of improving fish tail, neck and spot.
2. Tricarboxylic acid cycle-undaria pinnatifida extract
The tricarboxylic acid cycle has a key enzyme, namely mitochondrial aconitase, which is important for metabolism and can also protect the integrity of mitochondrial DNA; however, aconitase enzymes are specifically altered during aging by oxidative damage, resulting in loss of catalytic function. The Undaria pinnatifida extract has effects of activating aconitase, improving activity of mitochondrial aconitase, protecting mitochondrial DNA, regulating inflammatory reaction, and promoting collagen synthesis.
3. Undaria pinnatifida extract for improving cell respiration oxygen utilization rate
The "HIF respiratory signaling factor" was discovered by the young physiological or medical prize, 2019, revealing how cells perceived and adapted to the oxygen supply. Mitochondria are able to detect and respond to oxygen levels, and hypoxia is sensed to initiate a series of adaptive responses and activate Hypoxia Inducible Factor (HIF). Under the anoxic environment, mitochondria have a short-time energy synthesizing capacity, so that free radical release is reduced, undaria pinnatifida extract can wake up intracellular respiratory signal factors, up-regulate gene expression of HIF-1 alpha, convert aerobic metabolism into anaerobic metabolism, promote oxygenation capacity, promote cell life energy and improve metabolism of skin 4, matrix recombination facial extract-Cochinchinensis extract
The major biomechanical properties of skin, such as softness, firmness or elasticity, are related to some key extracellular matrix components: collagen, hyaluronic acid or elastin. As skin ages, one can observe an increase in the degradation rate of structural elements within the skin (collagen, hyaluronic acid, elastin, etc.), and a lack of regeneration, leading to skin sagging, lack of skin tension and firmness, and loss of clear facial contours.
The extract of Cochinotus nudus is a concentrated extract of Cochinotus nudus from sea, and is a unique effective component carrying strong algae bioactive substances, focusing on lower face relaxation, and used for resisting gravity effect on skin aging.
The preparation method of the Abies starburst algae extract comprises the steps of restarting the generation of key biomarkers in skin extracellular matrix, influencing the expression of a whole set of genes related to dermis structure, elastic fiber tissue and fiber degradation protection, restarting the production of collagen fibers, enhancing extracellular matrix and reconstructing dermis scaffolds (collagen and elastic fibers), improving dermis structure and skin elasticity, recovering softness, compactness and elasticity of skin, remodelling facial contours and solving the problem of skin relaxation.
The invention will be further illustrated with reference to specific examples. It should be understood that the detailed description and specific examples are intended for purposes of illustration only and are not intended to limit the scope of the invention.
The specific techniques or conditions are not identified in the examples and are described in the literature in this field or are carried out in accordance with the product specifications. The reagents or equipment used were conventional products available for purchase through regular channels, with no manufacturer noted.
The experimental methods in the following examples are conventional methods unless otherwise specified. The test materials used in the examples described below, unless otherwise specified, are all commercially available products.
Preparation examples:
example 1:
an anti-wrinkle tightening essence cream (product name is Sushengyuan AGE-Shine TM ) The composite material consists of the following components in percentage by weight: 2.5% of cetostearyl alcohol, 2% of cetostearyl glucoside, 1% of lecithin, 3% of hydrogenated polyisobutene, 1% of jojoba seed oil, 5% of squalane, 3% of polydimethylsiloxane, 0.05% of EDTA-2NA, 0.1% of Abies starburst algae (GIGARTINA STELLATA) extract, 0.1% of undaria pinnatifida (Undaria Pinnatifida) extract and phosphorus mannoseSodium oleate 0.1%, carbomer 0.45%, glycerin 2%, methyl propylene glycol 4%, panthenol 1%, arginine 0.3%, phenoxyethanol 0.25%, ethylhexyl glycerin 0.05%, p-hydroxyacetophenone 0.2%, and the balance water.
The preparation method of the anti-wrinkle tightening essence cream is as follows:
(1) Sequentially adding cetostearyl alcohol, cetostearyl glucoside, lecithin hydrogenated polyisobutene, jojoba seed oil, squalane and polydimethylsiloxane into an oil phase pot, heating to 80-85 ℃, and stirring for 10min at a constant temperature;
(2) Sequentially adding water, EDTA-2NA, carbomer, glycerol and methyl propylene glycol into a water phase pot, heating to 80-85 ℃, and stirring for 10min under heat preservation;
(3) Then extracting the raw materials of the water phase pot and the oil phase pot into an emulsifying pot, starting homogenizing emulsification, stirring for 10min, then cooling to 60 ℃, adding arginine into the emulsifying pot, stirring for neutralization completely, and continuously cooling to 45 ℃;
(4) Sequentially adding panthenol, phenoxyethanol, abies astrospora (GIGARTINA STELLATA) extract, undaria pinnatifida (Undaria Pinnatifida) extract, sodium mannose phosphate, ethylhexyl glycerol and p-hydroxyacetophenone into an emulsifying pot, and stirring uniformly;
(5) And discharging after the inspection is qualified.
Example 2:
an anti-wrinkle tightening essence cream consists of the following components in percentage by weight: cetostearyl alcohol 2.5%, cetostearyl glucoside 2%, lecithin 1%, hydrogenated polyisobutene 3%, macadamia nut oil 1%, squalane 5%, polydimethylsiloxane 3%, EDTA-2NA 0.05%, cochuria starchinesis (GIGARTINA STELLATA) extract 0.05%, undaria pinnatifida (Undaria Pinnatifida) extract 0.05%, sodium mannose phosphate 0.2%, carbomer 0.45%, glycerol 2%, 1, 3-butanediol 4%, panthenol 1%, arginine 0.3%, phenoxyethanol 0.25%, ethylhexyl glycerol 0.05%, p-hydroxyacetophenone 0.2%, and the balance water.
The preparation method of the anti-wrinkle tightening essence cream is the same as that of example 1.
Comparative example 1:
a face cream consists of the following components in percentage by weight: cetostearyl alcohol 2.5%, cetostearyl glucoside 2%, lecithin 1%, hydrogenated polyisobutene 3%, jojoba seed oil 1%, squalane 5%, polydimethylsiloxane 3%, EDTA-2NA 0.05%, sodium mannose phosphate 0.3%, carbomer 0.45%, glycerol 2%, methyl propylene glycol 4%, panthenol 1%, arginine 0.3%, phenoxyethanol 0.25%, ethylhexyl glycerol 0.05%, p-hydroxyacetophenone 0.2%, and the balance water.
The cream was prepared as in example 1, except that the extract of Huperzia serrata (GIGARTINA STELLATA) and the extract of undaria pinnatifida (Undaria Pinnatifida) were not added in the step (4).
Comparative example 2:
a face cream consists of the following components in percentage by weight: 2.5% of cetostearyl alcohol, 2% of cetostearyl glucoside, 1% of lecithin, 3% of hydrogenated polyisobutene, 1% of jojoba seed oil, 5% of squalane, 3% of polydimethylsiloxane, 0.05% of EDTA-2NA, 0.3% of Cochuria starchinense (GIGARTINA STELLATA) extract, 0.45% of carbomer, 2% of glycerol, 4% of methyl propylene glycol, 1% of panthenol, 0.3% of arginine, 0.25% of phenoxyethanol, 0.05% of ethylhexyl glycerol, 0.2% of p-hydroxyacetophenone and the balance of water.
The cream was prepared in the same manner as in example 1, except that sodium mannose phosphate and undaria pinnatifida (Undaria Pinnatifida) extract were not added in the step (4).
Comparative example 3:
a face cream consists of the following components in percentage by weight: 2.5% of cetostearyl alcohol, 2% of cetostearyl glucoside, 1% of lecithin, 3% of hydrogenated polyisobutene, 1% of jojoba seed oil, 5% of squalane, 3% of polydimethylsiloxane, 0.05% of EDTA-2NA, 0.3% of undaria pinnatifida (Undaria Pinnatifida) extract, 0.45% of carbomer, 2% of glycerol, 4% of methyl propylene glycol, 1% of panthenol, 0.3% of arginine, 0.25% of phenoxyethanol, 0.05% of ethylhexyl glycerol, 0.2% of p-hydroxyacetophenone and the balance of water.
The cream was prepared in the same manner as in example 1, except that sodium mannose phosphate and extract of huperzia starring (GIGARTINA STELLATA) were not added in step (4).
Comparative example 4:
a face cream consists of the following components in percentage by weight: 2.5% of cetostearyl alcohol, 2% of cetostearyl glucoside, 1% of lecithin, 3% of hydrogenated polyisobutene, 1% of jojoba seed oil, 5% of squalane, 3% of polydimethylsiloxane, 0.05% of EDTA-2NA, 0.1% of Abies starbuchneri (GIGARTINA STELLATA) extract, 0.1% of undaria pinnatifida (Undaria Pinnatifida) extract, 0.1% of vitronectin, 0.45% of carbomer, 2% of glycerol, 4% of methylpropanediol, 1% of panthenol, 0.3% of arginine, 0.25% of phenoxyethanol, 0.05% of ethylhexyl glycerol, 0.2% of p-hydroxyacetophenone and the balance of water.
The cream was prepared in the same manner as in example 1, except that sodium mannose phosphate in step (4) was replaced with a glassy agent.
Comparative example 5:
a face cream consists of the following components in percentage by weight: 2.5% of cetostearyl alcohol, 2% of cetostearyl glucoside, 1% of lecithin, 3% of hydrogenated polyisobutene, 1% of jojoba seed oil, 5% of squalane, 3% of polydimethylsiloxane, 0.05% of EDTA-2NA, 0.1% of Fucus vesiculosus extract, 0.1% of Undaria pinnatifida (Undaria Pinnatifida) extract, 0.1% of sodium mannose phosphate, 0.45% of carbomer, 2% of glycerol, 4% of methyl propylene glycol, 1% of panthenol, 0.3% of arginine, 0.25% of phenoxyethanol, 0.05% of ethylhexyl glycerol, 0.2% of p-hydroxyacetophenone and the balance of water.
The preparation of the cream was the same as in example 1, except that the extract of the huperzia serrata in step (4) was replaced with the extract of fucus.
Effect examples:
effect example 1: safety test
1. Test product:
example 1.
2. Negative control:
blank control.
3. The subject:
30 total, male 1, female 29, ages 20 to 59, average ages 45.6+ -9.7, and meets the subject's volunteer inclusion criteria.
4. The patch method comprises the following steps:
selecting a qualified patch tester, placing about 0.02-0.025mL of a test object into the patch tester by a closed patch test method, applying a medical adhesive tape for external use on the back of a subject, removing the test object after 24 hours, observing skin reactions after 0.5, 24 and 48 hours after removing the patch, and recording the results according to the skin reactions standard in cosmetic safety technical Specification (2015 edition).
Table 1: summarizing test results of cosmetic human skin patches
As is clear from table 1, the test results of the human skin closed patch showed that the skin adverse reaction occurred in 0 cases among 30 persons, and the test object did not cause skin adverse reaction to the subjects in the present lot according to the specification of the cosmetic safety technical Specification (2015 edition), so the cosmetic in example 1 was in accordance with the detection specification.
Effect example 2: free radical scavenging effect of the cosmetic compositions of the present invention
DPPH is a stable free radical with nitrogen as a center, and the determination of DPPH clearance is a simple, rapid and sensitive method for evaluating the antioxidant activity of natural active substances at present. The antioxidant activity of the creams prepared in examples 1-2 and comparative examples 1-5 was evaluated by constructing a DPPH radical scavenging reaction system.
Table 2: free radical scavenging effect of the cosmetic compositions of the present invention
As can be seen from the experimental results of Table 2, the creams prepared in examples 1-2 of the present invention were significantly superior to the creams prepared in comparative examples 1-5 and the blank cream base described in comparative example 6 in scavenging free radicals.
Also, as shown in the results of comparative examples 1 to 3 in table 2, when the cream contains only one of three active ingredients of the extract of huperzia starring (GIGARTINA STELLATA), the extract of undaria pinnatifida (Undaria Pinnatifida) or sodium mannose phosphate, the effect in scavenging free radicals is remarkably inferior to the combined group of the three, although the amount thereof in the cosmetic composition is the same. The results indicate that the combination of the three active ingredients produces a significant synergistic effect in scavenging free radicals.
It can also be seen from the results of comparative examples 4 and 5 that three components, namely, the extract of astrospora sinensis (GIGARTINA STELLATA), the extract of undaria pinnatifida (Undaria Pinnatifida) and sodium mannose phosphate, are special and irreplaceable, and the effect of scavenging free radicals of the corresponding face cream is remarkably reduced after being replaced with other components having similar effects in the cosmetic field.
In addition, as shown in comparative example 6, the conventional cosmetic base for preparing a face cream alone has substantially no effect of scavenging free radicals.
Effect example 3: antioxidant effect of the cosmetic composition of the present invention
1. Evaluation principle
Reactive Oxygen Species (ROS) are oxygen-containing chemically reactive chemicals. Including peroxides, superoxides, hydroxyl radicals, and the like. ROS are formed as natural byproducts of normal metabolism of oxygen and have important roles in cell signaling and homeostasis. However, ROS levels increase dramatically during uv exposure. This can cause serious damage to the cellular structure, which is known as oxidative stress. Oxidative stress occurs when the free radical production is greater than the body scavenging capacity. Menadione can generate active oxygen free radicals, and when the free radical generation amount is larger than the organism scavenging capacity, oxidation stress reaction occurs, and the antioxidation effect of the test sample is evaluated through the fluorescence intensity of the zebra fish yolk sac.
2. Experimental protocol
The tested zebra fish were divided into several groups, including normal control group, model control group, examples 1-2 and comparative examples 1-6. Wherein the normal control group was not treated with any treatment, the model control group and the groups of examples 1-2 and comparative examples 1-6 were all added with an equal amount of menaquinone. Examples 1-2 and comparative examples 1-6 samples prepared in examples 1-2 and comparative examples 1-6 were added at a concentration of menaquinone at the same time. After a period of time, the whole zebra fish is subjected to specific fluorescent staining, and the generation condition of active oxygen free radicals in the yolk sac of the zebra fish is observed.
3. Evaluation index
Yolk sac ROS fluorescence intensity
4. Experimental sample
Samples prepared in groups 1-2 and comparative examples 1-6.
5. Basis of judgment
And (3) statistically analyzing that p is less than 0.05, the efficacy value is more than or equal to 20%, and judging that the effect is effective.
6. Experimental results
The experimental results are shown in table 3. A representative antioxidant photograph of example 1 is shown in figure 1.
Table 3: results of antioxidant efficacy test of cosmetic compositions of the present invention
As can be seen from the experimental results of Table 3, the creams prepared in examples 1-2 of the present invention have significantly better antioxidant effect than the creams prepared in comparative examples 1-5 and the blank cream base described in comparative example 6.
Also, as shown in the results of comparative examples 1 to 3 in table 3, when the cream contains only one of three active ingredients of the extract of huperzia starring (GIGARTINA STELLATA), the extract of undaria pinnatifida (Undaria Pinnatifida) or sodium mannose phosphate, the effect on antioxidation is remarkably inferior to the combined group of the three although the amount is the same in the cosmetic composition. The results show that the combination of the three active ingredients produces a significant synergistic effect in terms of antioxidation.
It can also be seen from the results of comparative examples 4 and 5 that three components, namely, the extract of astrospora sinensis (GIGARTINA STELLATA), the extract of undaria pinnatifida (Undaria Pinnatifida) and sodium mannose phosphate, are special and irreplaceable, and the oxidation resistance effect of the corresponding cream is remarkably reduced after being replaced with other components having similar effects in the cosmetic field.
In addition, as shown in comparative example 6, the conventional cosmetic base used alone for preparing a face cream has substantially no effect on antioxidation.
As can be seen from fig. 1, the yolk sac fluorescence intensity of example 1 is significantly reduced compared with the control group of the residual model, indicating that the sample has significant antioxidant effect.
Effect example 4: human efficacy testing
1. Purpose of test
Skin tightness test was performed by using an instrument by using 4-week samples continuously from adult female volunteers under normal conditions, and the skin roughness and skin fish tail area ratio were photographed and analyzed to evaluate the anti-wrinkle and tightening effects of the test subjects.
2. Test article
Example 1, method of use: after the face is cleaned and the skin is refreshed, a proper amount of the product is evenly smeared on the face skin, and the product is gently massaged until the product is absorbed. The used part and frequency of the test are as follows: the face sample side is used once each after cleaning the face in the morning and evening.
3. Subject completion
Qualified subjects were enrolled 34 persons, aged 29-55 years. Of these, 4 subjects had fallen off because of non-compliance in usage. All 30 subjects were tested on demand for a trial of 28 days with an average age of 44.8.+ -. 7.69 years.
4. Evaluation, test item description
4.1 skin roughness:
photographs were taken using VISA-CR and analyzed with IPP.
Parameter description: texture duty cycle in the skin selection area; the larger the duty cycle, the rougher the skin.
And (3) result judgment: the skin roughness on the sample side is obviously reduced (P is less than 0.05) or the skin roughness difference on the sample side is obviously improved (P is less than 0.05) compared with the skin roughness on the control side before and after the test product, which shows that the test object has the effect of improving the skin roughness.
4.2 skin fish tail area ratio:
photographs were taken using VISA-CR and analyzed with IPP.
Parameter description: the area ratio of fish tail in the skin selected area; the smaller the ratio, the fewer wrinkles.
And (3) result judgment: the skin fish tail area of the sample side is obviously reduced (P is less than 0.05) before and after the test product is tested, or the skin fish tail area of the sample side is obviously improved (P is less than 0.05) compared with the control side, so that the test object has anti-wrinkle effect.
4.3 skin firmness F4 value:
the elastic tester was used to measure the overall amplitude log curve area of the skin during ten consecutive negative pressure cycles.
Parameter description: reflecting the degree of skin firmness; the smaller the measured value, the tighter the skin.
And (3) result judgment: after the product is tried out, the skin compactness F4 value of the sample side is obviously improved (P is less than 0.05), or the skin compactness F4 value difference of the sample side is obviously improved compared with the control side (P is less than 0.05), which shows that the test object has the compacting effect.
5. Test environment
Environmental requirements: temperature: (21+ -1) deg.C; relative humidity: (50.+ -. 10)%.
6. Test design
The test object is used on one side of the left side surface part and the right side surface part of the test object at random, the test object is not used on the other side, any product cannot be smeared on the test object on the same day, the clean water is uniformly used for cleaning the face, and the test is carried out after the test object is statically sitting in a constant temperature chamber for half an hour. The sample side and control side skin firmness F4 was tested before trial (D0) and after trial 28 days (D28); VISIA-CR photographs were taken and analyzed for sample side and control side skin roughness and fish tail area ratios using IPP image analysis software. The results or differences before and after use of the test object itself are compared with the comparison of the difference on the control side for statistical differences.
7. Test results
Table 4: instrument test results (30 person)
Note that: effectiveness is as follows: ". V" indicates effective (improved result and p < 0.05); "×" indicates no effect (improved results but p > 0.05 or p <0.05 but worse results).
8. Conclusion of the test
Under the test condition, after the product is tested for 28 days, the difference of the front and rear skin roughness of the side face of the sample is obviously improved compared with that of the control side (P is less than 0.05), so that the test object has the effect of improving the skin roughness.
Under the test condition, after the product is tested for 28 days, the difference of the front and rear skin fish tail area ratio of the side face of the sample is obviously improved compared with the comparison side (P is less than 0.05), so that the test object has anti-wrinkle effect.
Under the test condition, after the product is tested for 28 days, the F4 value of the skin compactness of the side face of the sample is obviously reduced (P is less than 0.05), and the difference value between the front and back is obviously improved compared with the comparison side (P is less than 0.05), so that the test object has the effect of improving the skin compactness.
In conclusion, under the test conditions, the test object has anti-wrinkle and tightening effects.
It will be apparent to those skilled in the art that various modifications and variations can be made to the present invention without departing from the spirit or scope of the invention. Thus, it is intended that the present invention also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (10)
1. An anti-wrinkle compact cosmetic composition characterized by: the cosmetic composition comprises sodium mannose phosphate, a huperzia serrata (GIGARTINA STELLATA) extract and a undaria pinnatifida (Undaria Pinnatifida) extract, wherein the weight ratio of the sodium mannose phosphate is as follows: extract of huperzia serrata (GIGARTINA STELLATA): undaria pinnatifida (Undaria Pinnatifida) extract= (1-50): (1-50): (1-50).
2. The cosmetic composition according to claim 1, characterized in that: sodium mannose phosphate, in weight ratio: extract of huperzia serrata (GIGARTI NASTELLATA): undaria pinnatifida (Undaria Pinnatifida) extract= (1-20): (1-20): (1-20).
3. A cosmetic preparation for anti-wrinkle tightening, characterized in that: the cosmetic preparation comprises the cosmetic composition according to claim 1 or claim 2 and conventional adjuvants in the cosmetic field.
4. A cosmetic formulation according to claim 3, characterized in that: the cosmetic preparation is selected from toner, lotion, essence, cream or facial mask.
5. A cosmetic formulation according to claim 3, characterized in that: the cosmetic preparation comprises the following components in percentage by weight:
mannose sodium phosphate 0.01-0.5%
0.01-0.5% of Abies starburst algae (GIGARTINA STELLATA) extract
0.01-0.5% Undaria pinnatifida (Undaria Pinnatifida) extract
Humectant 1-20%
Preservative 0.01-1%
Emulsifying agent 0.1-5%
Chelating agent 0.01-1%
0.1 to 10 percent of thickening agent
Emollient 1-20%
pH regulator 0.01-1%
The balance of water.
6. The cosmetic formulation of claim 5, wherein: the humectant is selected from any one or more than two of methyl propylene glycol, 1, 3-butanediol, glycerol polyether-26 or panthenol.
7. The cosmetic formulation of claim 5, wherein: the preservative is selected from any one or more than two of phenoxyethanol, potassium sorbate, ethylhexyl glycerol, methylparaben or ethylparaben; the chelating agent is selected from EDTA-2NA and/or p-hydroxyacetophenone; the thickener is selected from carbomer and/or cetostearyl alcohol; the pH regulator is selected from triethanolamine and/or arginine.
8. The cosmetic formulation of claim 5, wherein: the emulsifier is selected from one or more than two of cetostearyl glucoside, lecithin, PEG-40, stearate or glyceryl stearate.
9. The cosmetic formulation of claim 5, wherein: the emollient is selected from one or more of macadamia nut oil, plant-derived hydrogenated oil, squalane, jojoba seed oil, hydrogenated polyisobutene, white mineral oil or polydimethylsiloxane.
10. Use of the cosmetic composition according to claim 1 or claim 2 or the cosmetic preparation according to any one of claims 3 to 9 for the preparation of a cosmetic having anti-wrinkle tightening efficacy.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310955491.4A CN116747158B (en) | 2023-08-01 | 2023-08-01 | Cosmetic composition capable of resisting wrinkle and compacting through mitochondria and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310955491.4A CN116747158B (en) | 2023-08-01 | 2023-08-01 | Cosmetic composition capable of resisting wrinkle and compacting through mitochondria and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116747158A CN116747158A (en) | 2023-09-15 |
| CN116747158B true CN116747158B (en) | 2024-01-23 |
Family
ID=87957423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310955491.4A Active CN116747158B (en) | 2023-08-01 | 2023-08-01 | Cosmetic composition capable of resisting wrinkle and compacting through mitochondria and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116747158B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117618280B (en) * | 2024-01-26 | 2024-04-30 | 杭州译象生物科技有限公司 | Collagen anti-aging composition and application thereof |
| CN118436552B (en) * | 2024-04-18 | 2024-11-26 | 梅晔生物医药股份有限公司 | A mitochondrial composition and its application, daily chemical product |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150062624A (en) * | 2013-11-29 | 2015-06-08 | 한국콜마주식회사 | Cosmetic Composition Comprising Gracilaria verrucosa (Hudson) Paperfuss Extract, Undaria peterseniana Extract and Sargassum siliquastrum (Mertens) C. Agardh Extract |
| KR101716106B1 (en) * | 2016-04-18 | 2017-04-06 | 주식회사 단정바이오 | Seaweed mixed fermentation with an anti-inflammatory, anti-allergic and atopic skin improvement, a preparation method thereof and a cosmetic composition of the same |
| FR3061013A1 (en) * | 2016-12-22 | 2018-06-29 | Greenpharma | COMPOSITION COMPRISING DIGENEASIDE, PROCESS FOR OBTAINING SAME AND COSMETIC, VETERINARY OR NUTRACEUTICAL USE |
| CN113786362A (en) * | 2021-09-26 | 2021-12-14 | 湖北省麦诗特生物科技有限公司 | Toning lotion composition with effects of relieving, balancing and protecting skin and preparation method thereof |
| CN114557938A (en) * | 2022-02-09 | 2022-05-31 | 珠海伊斯佳科技股份有限公司 | Composition with brightening, compacting and anti-wrinkle functions and preparation method and application thereof |
| CN115844748A (en) * | 2022-12-16 | 2023-03-28 | 优颜皮肤科学研究(广州)有限公司 | Eye composition and preparation method and application thereof |
| CN116077410A (en) * | 2023-01-09 | 2023-05-09 | 广州颜朵化妆品科技有限公司 | Composition and preparation with skin barrier repairing function, and preparation and application thereof |
-
2023
- 2023-08-01 CN CN202310955491.4A patent/CN116747158B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150062624A (en) * | 2013-11-29 | 2015-06-08 | 한국콜마주식회사 | Cosmetic Composition Comprising Gracilaria verrucosa (Hudson) Paperfuss Extract, Undaria peterseniana Extract and Sargassum siliquastrum (Mertens) C. Agardh Extract |
| KR101716106B1 (en) * | 2016-04-18 | 2017-04-06 | 주식회사 단정바이오 | Seaweed mixed fermentation with an anti-inflammatory, anti-allergic and atopic skin improvement, a preparation method thereof and a cosmetic composition of the same |
| FR3061013A1 (en) * | 2016-12-22 | 2018-06-29 | Greenpharma | COMPOSITION COMPRISING DIGENEASIDE, PROCESS FOR OBTAINING SAME AND COSMETIC, VETERINARY OR NUTRACEUTICAL USE |
| CN113786362A (en) * | 2021-09-26 | 2021-12-14 | 湖北省麦诗特生物科技有限公司 | Toning lotion composition with effects of relieving, balancing and protecting skin and preparation method thereof |
| CN114557938A (en) * | 2022-02-09 | 2022-05-31 | 珠海伊斯佳科技股份有限公司 | Composition with brightening, compacting and anti-wrinkle functions and preparation method and application thereof |
| CN115844748A (en) * | 2022-12-16 | 2023-03-28 | 优颜皮肤科学研究(广州)有限公司 | Eye composition and preparation method and application thereof |
| CN116077410A (en) * | 2023-01-09 | 2023-05-09 | 广州颜朵化妆品科技有限公司 | Composition and preparation with skin barrier repairing function, and preparation and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN116747158A (en) | 2023-09-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN116747158B (en) | Cosmetic composition capable of resisting wrinkle and compacting through mitochondria and application thereof | |
| CN105125476B (en) | A kind of anti-wrinkle essence and preparation method thereof | |
| CN107213063B (en) | Fair and bright facial mask and preparation method thereof | |
| CN110742842B (en) | Essence composition for delaying skin aging and preparation method thereof | |
| CN111450010A (en) | Composition with anti-aging effect and application thereof in cosmetics | |
| CN107233236B (en) | Fair and bright whitening cream and preparation method thereof | |
| CN115040464B (en) | Essence composition with wrinkle-removing and anti-aging effects and preparation method thereof | |
| CN113576975B (en) | Easily-absorbed anti-aging composition and preparation method and application thereof | |
| CN109431914A (en) | Scalp care composition and application thereof | |
| CN113018230A (en) | Composition and preparation method and application thereof | |
| CN107412042A (en) | It is a kind of that there is the cosmetic composition for repairing and strengthening skin barrier function and application | |
| CN112842985A (en) | Moisturizing and repairing composition | |
| CN116327674B (en) | Anti-wrinkle and firming micro-nano essence lotion and preparation method thereof | |
| EP2763652B1 (en) | Use of glucans obtained from prunus persica as an anti-aging cosmetic agent | |
| CN111012699A (en) | Antioxidant oil-controlling emulsion containing fucoidan-kelp extract | |
| CN115844748A (en) | Eye composition and preparation method and application thereof | |
| CN109431910B (en) | Skin barrier repair composition and application thereof | |
| CN115844804A (en) | Composition for improving exogenous aging and preparation method and application thereof | |
| CN110801411A (en) | Moisturizing, moisturizing and whitening emulsion and preparation method thereof | |
| FR3003167A1 (en) | COSMETIC OR DERMATOLOGICAL COMPOSITION AND USE THEREOF | |
| CN116898790B (en) | Composition with anti-wrinkle repairing effect and application thereof | |
| CN112842987A (en) | Whitening effect composition, preparation method and application thereof, and whitening essence | |
| TW202106323A (en) | Use ofrosmarinus officinaliscallus extract for manufacturing composition inhibiting skin aging and a culture medium for inducingrosmarinus officinaliscallus | |
| CN110585079A (en) | Radiation-resistant composition containing food-borne peptide and radiation-resistant emulsion thereof | |
| CN116831971A (en) | Anti-aging nanometer composition, preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |