CN116712051B

CN116712051B - Noninvasive blood pressure measurement method and device, computer equipment and storage medium

Info

Publication number: CN116712051B
Application number: CN202310673295.8A
Authority: CN
Inventors: 何子军; 陈焱焱; 徐玉兵; 王彦彩; 李冕; 王翔; 曹庆庆; 王东; 王志成
Original assignee: Hefei Zhongke Boxie Technology Co ltd
Current assignee: Hefei Zhongke Boxie Technology Co ltd
Priority date: 2023-06-08
Filing date: 2023-06-08
Publication date: 2024-07-02
Anticipated expiration: 2043-06-08
Also published as: CN116712051A

Abstract

The invention is applicable to the field of electric digital data processing, and provides a noninvasive blood pressure measurement method, a noninvasive blood pressure measurement device, computer equipment and a storage medium, wherein the noninvasive blood pressure measurement method comprises the following steps of: changing the wall-crossing pressure of arterial blood vessels at the cuff binding part, wherein the maximum value of the changed wall-crossing pressure is smaller than or equal to a first pressure threshold value; acquiring cross-wall pressure information of a subject, and acquiring heart sound information and radial artery pulse wave information of the subject; identifying a second heart sound feature point in the heart sound information and identifying a descending isthmus feature point in the radial artery pulse wave information; obtaining pulse wave conduction time according to the difference of the second heart sound characteristic points and the descending isthmus characteristic points on time sequence; and establishing a corresponding relation between the pulse wave conduction time and the wall-crossing pressure information, and generating a change trend of the pulse wave conduction time. According to the invention, the blood pressure value is not inferred based on empirical data, and the diastolic pressure and the systolic pressure can be more accurately calculated through the change trend of PTT.

Description

Noninvasive blood pressure measurement method and device, computer equipment and storage medium

Technical Field

The invention belongs to the field of electric digital data processing, and particularly relates to a noninvasive blood pressure measurement method, a noninvasive blood pressure measurement device, computer equipment and a storage medium.

Background

Blood pressure is the pressure that acts on the vessel wall when blood flows in a blood vessel, is the motive force that pushes blood to flow in the blood vessel, and is one of important physiological parameters of the human body. The main principle of the current main stream noninvasive blood pressure measurement method is that the oscillometric method is adopted: by rapidly pressurizing the cuff tied to the limb, arterial blood flow is blocked, the pulsating oscillatory wave envelope derived from the vessel wall is detected during slow deflation of the cuff, and the inherent relationship between the envelope and arterial blood pressure is found out, and the systolic pressure, diastolic pressure and mean pressure of the artery are determined.

The method has the following main defects: determining the systolic pressure and the diastolic pressure according to the pulse wave vibration amplitude variation coefficient is based on empirical data, so that the accuracy of measurement is reduced; the method comprises the steps of completely blocking arterial blood flow by pressurizing a cuff, then, venting air to calculate the oscillation amplitude change coefficient of pulse wave to determine the blood pressure value, and measuring the systolic pressure easily affected by the complete blocking of arterial blood flow.

Disclosure of Invention

A first object of an embodiment of the present invention is to provide a noninvasive blood pressure measurement method, which can solve the following problems of the conventional oscillometric electronic blood pressure measurement method: 1. determining the systolic pressure and the diastolic pressure according to the pulse wave vibration amplitude variation coefficient is based on empirical data, so that the accuracy of measurement is reduced; 2. the arterial blood flow is completely blocked by pressurizing the cuff, then the pulse wave oscillation amplitude change coefficient is calculated by venting, the blood pressure value is determined, and the measurement result of the systolic pressure can be affected by the complete blocking of the arterial blood flow.

The embodiment of the invention is realized in such a way that a noninvasive blood pressure measurement method comprises the following steps:

changing the wall-crossing pressure of arterial blood vessels at the cuff binding part, wherein the maximum value of the changed wall-crossing pressure is smaller than or equal to a first pressure threshold value;

Acquiring cross-wall pressure information of a subject, and acquiring heart sound information and radial artery pulse wave information of the subject;

Identifying a second heart sound feature point in the heart sound information and identifying a descending isthmus feature point in the radial artery pulse wave information;

obtaining pulse wave conduction time according to the difference of the second heart sound characteristic points and the descending isthmus characteristic points on time sequence;

establishing a corresponding relation between the pulse wave conduction time and the wall-crossing pressure information, and generating a change trend of pulse wave conduction time (PTT);

and determining the arterial diastolic pressure and the arterial systolic pressure of the subject according to the change trend of the pulse wave conduction time, and outputting the arterial diastolic pressure and the arterial systolic pressure.

A second object of an embodiment of the present invention is to provide a non-invasive blood pressure measuring apparatus for a non-invasive blood pressure measuring method as described above, the non-invasive blood pressure measuring apparatus comprising: the system comprises a pressing module, an information acquisition module, a characteristic identification module, a PTT calculation module and a blood pressure value output module;

The pressure applying module is used for changing the wall-crossing pressure of the arterial vessel at the cuff binding part;

The information acquisition module is used for acquiring the cross-wall pressure information of the subject, and acquiring heart sound information and radial pulse wave information of the subject;

The characteristic recognition module is used for recognizing a second heart sound characteristic point in the heart sound information and recognizing a descending isthmus characteristic point in the radial artery pulse wave information;

The PTT calculation module is used for establishing a corresponding relation between the pulse wave conduction time and the wall-crossing pressure information and generating a change trend of the pulse wave conduction time;

And the blood pressure value output module is used for determining the arterial diastolic pressure and the arterial systolic pressure of the subject according to the change trend of the pulse wave transmission time and outputting the arterial diastolic pressure and the arterial systolic pressure.

Further, the non-invasive blood pressure measuring apparatus further comprises: the heart sound detection module, the radial artery detection module and the control module are electrically connected with the microprocessor;

The information acquisition module, the characteristic identification module, the PTT calculation module and the blood pressure value output module are all preset in the microprocessor;

the heart sound detection module is used for collecting heart sound signals of a subject, transmitting the heart sound signals to the information acquisition module as heart sound information, and processing the heart sound information by the characteristic recognition module to obtain second heart sound characteristic points;

The radial artery detection module is used for collecting radial artery pulse wave signals of a subject, transmitting the radial artery pulse wave signals to the information acquisition module as radial artery pulse wave information, and processing the radial artery pulse wave information by the characteristic recognition module to obtain characteristic points of the descending isthmus;

the microprocessor controls the operation of the pressing module through the control module.

A third object of an embodiment of the present invention is to provide a computer device, including a memory and a processor, where the memory stores a computer program or instructions that, when executed by the processor, cause the processor to perform the steps of the non-invasive blood pressure measurement method.

A fourth object of an embodiment of the present invention is to provide a computer-readable storage medium having stored thereon a computer program or instructions which, when executed by a processor, cause the processor to perform the steps of the non-invasive blood pressure measurement method.

According to the noninvasive blood pressure measurement method provided by the embodiment of the invention, the blood pressure value is not needed to be inferred based on empirical data, the arterial systolic pressure and arterial diastolic pressure (also called systolic pressure and diastolic pressure) of a subject are confirmed by the calculated change trend of PTT in the process of changing the transmural pressure in cooperation with the change of the transmural pressure, the influence of blood flow blocking on a blood pressure measurement result is avoided, and the diastolic pressure and the systolic pressure can be calculated more accurately and more accurately through the change trend of PTT.

Drawings

FIG. 1 is a block flow diagram of a method for noninvasive blood pressure measurement according to an embodiment of the present invention;

FIG. 2 is a flowchart of identifying a second heart sound feature point in the heart sound information and identifying a descending isthmus feature point in the radial pulse wave information according to an embodiment of the present invention;

FIG. 3 is a flowchart of determining the diastolic and systolic arterial pressures of a subject according to the trend of pulse transit time according to an embodiment of the present invention;

FIG. 4 is a schematic diagram showing the calculation of Pulse Transit Time (PTT) according to an embodiment of the present invention;

FIG. 5 is a graph showing the relationship between pulse transit time and cuff pressure in an embodiment of the present invention;

Fig. 6 is a block diagram of a noninvasive blood pressure measurement device according to an embodiment of the present invention;

FIG. 7 is a block diagram of another non-invasive blood pressure measurement apparatus according to an embodiment of the present invention;

FIG. 8 is a block diagram of the internal architecture of a computer device in one embodiment.

In the figure: 100-a pressing module; 200-an information acquisition module; 300-a feature recognition module; a 400-PTT computing module; 500-a blood pressure value output module; 1-a cuff; 2-an air valve; 3-an inflator; 4-an air pressure sensor; a 5-radial artery detection module; 6-a heart sound detection module; 7-a microprocessor; 8-a control module; 9-display module.

Detailed Description

The present invention will be described in further detail with reference to the drawings and examples, in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.

Fig. 1 is a flowchart of a non-invasive blood pressure measurement method according to an embodiment of the present invention, which specifically may include steps S101 to S111 shown in fig. 8:

step S101, changing the wall-crossing pressure of arterial blood vessels at the binding part of the cuff 1, wherein the maximum value of the changed wall-crossing pressure is smaller than or equal to a first pressure threshold value;

In this step, the change of the wall-crossing pressure can be achieved by means of the compression cuff 1, for example: implemented using the structure shown in fig. 7; other conventional ways of achieving an increase or decrease in the wall-spanning pressure may also be employed; when the wall-crossing pressure is changed, the pulse wave conduction path can change along with the change of the artery vessel inner diameter of the cuff binding part, and the pulse wave conduction time also changes; the principle thereof meets the following formula (1):

Setting the internal pressure of arterial blood vessels at the binding part of the cuff 1 as P ₁ and the cuff pressure as P ₂; and E is the Young's modulus of elasticity of the arterial vessel, h is the wall thickness of the vessel, r ₀ is the inner diameter of the vessel in a natural state, and r decreases as the cuff pressure P ₂ increases.

Step S103, obtaining cross-wall pressure information of a subject, and obtaining heart sound information and radial artery pulse wave information of the subject;

Wherein the wall-crossing pressure information can be characterized by cuff pressure information and can be acquired or acquired by an air pressure sensor 4 arranged in the cuff 1;

step S105, identifying a second heart sound characteristic point in the heart sound information and identifying a descending isthmus characteristic point in the radial pulse wave information;

In the step, the second heart sound characteristic point is marked as S2, and the S2 represents the time point when the aortic valve closes and the heart stops shooting; the characteristic point of descending the isthmus is marked as F, and the physiological meaning of F is the time point when the heart stops shooting; similarly, the first heart sound feature point is marked as S1; see in particular fig. 4.

Step S107, obtaining pulse wave conduction time according to the difference of the second heart sound characteristic point and the descending isthmus characteristic point in time sequence;

In this step, the pulse wave conduction time can be calculated by using the Moens-Korteweg formula (formula 2 below), and is recorded as PTT, so that the following conditions are satisfied:

Where ρ is the blood density, it is known that PTT decreases with decreasing inside diameter of the blood vessel. When the cuff pressure P ₂ reaches the diastolic pressure DBP, if the cuff pressure continues to increase, the arterial vessel inside diameter begins to appear below r ₀, young's modulus E increases, and PPT decreases with acceleration.

Thus, as can be seen from fig. 5, the relationship between PTT and cuff pressure P ₂ appears as:

When P ₂ is more than 0 and DBP is more than 0, PTT is slowly reduced along with the increase of P ₂;

When DBP is less than or equal to P ₂, PTT starts to accelerate to decrease along with the increase of P ₂;

P ₂ = SBP, the ptt down trend is not apparent as the vessel inside diameter approaches 0.

Step S109, establishing a corresponding relation between the pulse wave conduction time and the wall-crossing pressure information, and generating a change trend of the pulse wave conduction time;

In the step, the blood pressure measurement principle is creatively improved, the wall-crossing pressure of an arterial blood vessel is changed by using a cuff pressurization mode, the pulse wave conduction time is influenced by changing the radius of the blood vessel, and the arterial systolic pressure and the arterial diastolic pressure are determined by using the relation between the wall-crossing pressure P ₂ and the pulse wave conduction time, namely PTT; the corresponding relation between the pulse wave conduction time and the wall-crossing pressure information is the change process of the cuff pressure and the change process of the pulse wave conduction time. Because the process of determining the systolic pressure and the diastolic pressure does not involve the equation relationship between the pulse wave conduction time and the arterial blood pressure, no empirical data is needed, and the accuracy of measurement can be improved. In addition, the acquisition of data is different from the traditional oscillometric blood pressure measurement mode: firstly, pressurizing the cuff until the blood vessel is completely blocked, and then measuring the blood pressure value in the deflation process of the cuff; there is no measurement that a complete blockage of arterial blood flow might affect systolic pressure; therefore, the principle innovation in many aspects brings the effects of accuracy and convenience of the measurement result.

And step S111, determining the arterial diastolic pressure and the arterial systolic pressure of the subject according to the change trend of the pulse wave transmission time, and outputting the arterial diastolic pressure and the arterial systolic pressure.

In this step, as described above, the trend of the pulse wave conduction time is that the wall-crossing pressure of the arterial vessel is changed by the pressurization mode, so that the inner diameter of the arterial vessel is changed to influence the pulse wave conduction time, and in this process, the pressurization process of the wall-crossing pressure corresponds to the change of the pulse wave conduction time one by one;

In this embodiment, the noninvasive blood pressure measurement method does not need to infer a blood pressure value based on empirical data, confirms arterial systolic pressure and arterial diastolic pressure of a subject by the calculated change trend of PTT in the process of changing the transmural pressure in cooperation with the change of the transmural pressure, avoids blocking the influence of blood flow on a blood pressure measurement result, and can calculate the diastolic pressure and the systolic pressure more accurately through the change trend of PTT at the same time, so that the accuracy is higher.

In an example of an embodiment, the method comprises:

When the cuff pressure is 0, calculating pulse wave conduction time PTT (0) according to the acquired heart sound signals and radial artery pulse wave signals; the collected heart sound signals and radial artery pulse wave signals can be generated into the following signals through analog-to-digital conversion: heart sound information and radial pulse wave information;

Inflating and pressurizing the cuff, and recording pulse wave conduction time PTT (P) under the current cuff pressure condition;

The pulse wave conduction time PTT is reduced along with the increase of the cuff pressure, and when the pulse wave conduction time PTT is increased along with the increase of the cuff pressure, the cuff pressure at the moment of starting to accelerate and decline is the diastolic pressure (or arterial diastolic pressure); as the cuff pressure continues to increase, the cuff pressure at the point in time when the pulse transit time PPT changes minimally is the systolic pressure (or arterial systolic pressure).

As shown in fig. 2, in one embodiment, the step of identifying the second heart sound feature point in the heart sound information and identifying the descending isthmus feature point in the radial pulse wave information specifically includes:

s201, identifying a first heart sound characteristic point in the heart sound information, and judging a second heart sound characteristic point according to the first heart sound characteristic point;

s203, identifying the descending isthmus characteristic point in the radial pulse wave information by taking the second heart sound characteristic point as an identification starting point.

In this embodiment, as shown in fig. 5, PTT decreases as the inside diameter of the blood vessel decreases; when the cuff pressure P ₂ reaches the diastolic pressure DBP, if the cuff pressure continues to increase, the arterial vessel inner diameter begins to appear below r ₀, the Young's modulus E increases, and the PPT decreases rapidly.

In one example of the present embodiment, as shown in fig. 3, the step of determining the arterial diastolic pressure and the arterial systolic pressure of the subject according to the trend of the pulse wave transit time specifically includes:

s301, dividing the change trend of pulse wave conduction time into a plurality of change curve segments;

S303, comparing curvatures of adjacent change curve segments, and marking the position corresponding to the wall-crossing pressure information when the curvatures are suddenly changed for the first time as a first pressure value to serve as arterial diastolic pressure; and marking the position corresponding to the wall-crossing pressure information when the curvature is subjected to the second abrupt change as a second pressure value, and taking the second pressure value as arterial systolic pressure.

Of course, the curvature of the adjacent change curve sections can be compared, and the change trend of the established pulse wave conduction time can be realized by identifying images; in some cases, a one-to-one correspondence relationship between the pressurization process of the wall-crossing pressure and the change of the pulse wave conduction time can be generated according to the change trend of the pulse wave conduction time, so that a reference table is manufactured, conventional mathematical calculation is performed on the reference table, the moment at which the curvature is suddenly changed is obtained, and then the position corresponding to the wall-crossing pressure information is obtained; of course, the present example is not limited thereto.

In one embodiment, the heart sound information and radial pulse wave information are denoised in the step of identifying a second heart sound feature point in the heart sound information and identifying a descending isthmus feature point in the radial pulse wave information.

In this embodiment, the noise reduction of the heart sound information and the radial pulse wave information may be implemented by using a fourier transform equation.

In another embodiment, as shown in fig. 6, a non-invasive blood pressure measuring apparatus for use in a non-invasive blood pressure measuring method as described above, the non-invasive blood pressure measuring apparatus comprising: the device comprises a pressing module 100, an information acquisition module 200, a characteristic identification module 300, a PTT calculation module 400 and a blood pressure value output module 500;

the pressure applying module 100 is used for changing the wall-crossing pressure of the arterial vessel at the cuff binding part;

the information acquisition module 200 is configured to acquire wall pressure information of a subject, heart sound information of the subject, and radial pulse wave information;

The feature recognition module 300 is configured to recognize a second heart sound feature point in the heart sound information, and recognize a descending isthmus feature point in the radial artery pulse wave information;

the PTT calculation module 400 is configured to establish a correspondence between the pulse wave conduction time and the wall-crossing pressure information, and generate a trend of variation of the pulse wave conduction time;

the blood pressure value output module 500 determines the arterial diastolic pressure and the arterial systolic pressure of the subject according to the trend of the pulse wave transmission time, and outputs the arterial diastolic pressure and the arterial systolic pressure.

In one example of the present embodiment, the heart sound detection module 6 is a stethoscope, and the radial artery detection module 5 is a touch sensor; accordingly, the information acquisition module 200 may be a transmission line, a wireless network or a data interface, etc. connecting the stethoscope, the touch sensor and the microprocessor 7.

In an example of this embodiment, the PTT calculation module 400 may be configured based on the above formulas (1) and (2) to obtain Pulse Transit Time (PTT), and establish a correspondence between the pulse transit time and the wall-crossing pressure information to generate a trend of change in pulse transit time. The blood pressure value output module 500 may be a conventional data output bus, such as can bus, HDMI connection, etc.

For example, the modules above may be one or more integrated circuits configured to implement the methods above, such as: one or more Application SPECIFIC INTEGRATED Circuits (ASIC), or one or more digital signal processors (DIGITAL SIGNAL Processor, DSP), or one or more field programmable gate arrays (Field Programmable GATEARRAY, FPGA), etc. For another example, when a module above is implemented in the form of processing element scheduler code, the processing element may be a general purpose processor, such as a central processing unit (Central Processing Unit, CPU) or other processor that may invoke the program code. For another example, the modules may be integrated together and implemented in the form of a System-on-a-chip (SOC).

In the above embodiments, it may be implemented in whole or in part by software, hardware, firmware, or any combination thereof. When implemented in software, may be implemented in whole or in part in the form of a computer program product. The computer program product includes one or more computer instructions. When loaded and executed on a computer, produces, in whole or in part, the processes or functions described in accordance with embodiments of the present invention. The computer may be a general purpose computer, a special purpose computer, a computer network, or other programmable apparatus; the present embodiment includes but is not limited to this.

As shown in fig. 6 and 7, in one embodiment, the non-invasive blood pressure measurement apparatus further includes: the heart sound detection device comprises a microprocessor 7, a heart sound detection module 6, a radial artery detection module 5 and a control module 8, wherein the heart sound detection module 6, the radial artery detection module 5 and the control module 8 are electrically connected with the microprocessor 7;

The information acquisition module 200, the feature identification module 300, the PTT calculation module 400 and the blood pressure value output module 500 are all preset in the microprocessor 7;

the heart sound detection module 6 is configured to collect heart sound signals of the subject, transmit the heart sound signals as heart sound information to the information acquisition module 200, and obtain second heart sound feature points through processing by the feature recognition module 300;

The radial artery detection module 5 is configured to collect a radial artery pulse wave signal of the subject, transmit the radial artery pulse wave signal as radial artery pulse wave information to the information acquisition module 200, and obtain the characteristic points of the descending isthmus through processing by the characteristic recognition module 300;

the microprocessor 7 controls the operation of the pressing module 100 through the control module 8.

As shown in fig. 7, in one embodiment, the pressing module 100 includes: a cuff 1, and an air pressure sensor 4 provided in the cuff 1;

an air pressure cavity is arranged in the cuff 1, the volume of the air pressure cavity is variable, and the air pressure sensor 4 measures the arterial wall-crossing pressure of the binding part of the cuff 1 by measuring the air pressure of the air pressure cavity;

The air pressure cavity is connected with an inflator pump 3, and the inflator pump 3 is used for pressurizing the air pressure cavity;

The pneumatic cavity is provided with a pneumatic valve 2, and the pneumatic valve 2 is used for decompressing the pneumatic cavity.

In this embodiment, the microprocessor 7 controls the air pump 3 to inflate the air pressure chamber of the cuff 1, and the microprocessor 7 acquires and records the pulse wave conduction time PTT under the current cuff pressure condition through the air pressure sensor 4.

As shown in fig. 4, radial pulse wave signals of a subject are acquired through a radial artery detection module 5, heart sound signals are acquired through a heart sound detection module 6, and the cuff 1 and the inflator pump 3 cooperate to realize the function of pressurizing the wall pressure of an arterial vessel and block the arterial blood flow of the arm of the subject; the microprocessor 7 determines the time difference between the second heart sound time point and the radial descending isthmus, i.e., PTT, from the acquired radial artery signal and heart sound signal. The microprocessor 7 controls the inflator 3 to inflate until PTT is unchanged. And calculating the variation trend of the PTT according to the variation of the PTT in the inflation process, so as to determine the diastolic pressure and the systolic pressure of the subject. And the systolic pressure and the diastolic pressure of the subject are confirmed in the inflation process, the influence of blocking blood flow on a blood pressure measurement result can be avoided, and meanwhile, the diastolic pressure and the systolic pressure can be calculated more accurately through the change trend of PTT, so that the use experience and the test accuracy of the subject are improved.

As shown in fig. 7, in one embodiment, the non-invasive blood pressure measurement device further comprises: a display module 9;

The display module 9 is electrically connected to the microprocessor 7, and is configured to display the detection information of the heart sound detection module 6, the detection information of the radial artery detection module 5, and the blood pressure measurement result processed by the microprocessor 7.

In this embodiment, the display module 9 may be a display screen, a conventional oscilloscope, or other electronic devices with an image display function.

As shown in fig. 8, in one embodiment, a computer device includes a memory and a processor, the memory having stored therein a computer program or instructions that, when executed by the processor, cause the processor to perform steps S101-S111 of the non-invasive blood pressure measurement method;

Step S101, changing the wall-crossing pressure of arterial blood vessels at the cuff binding part, wherein the maximum value of the changed wall-crossing pressure is smaller than or equal to a first pressure threshold value;

In one embodiment, a computer readable storage medium has stored thereon a computer program or instructions that, when executed by a processor, cause the processor to perform steps S101 to S111 of the non-invasive blood pressure measurement method;

FIG. 8 illustrates an internal block diagram of a computer device in one embodiment. The computer device includes a processor, a memory, a network interface, an input device, and a display screen connected by a system bus. The memory includes a nonvolatile storage medium and an internal memory. The non-volatile storage medium of the computer device stores an operating system, and may also store a computer program that, when executed by the processor, causes the processor to implement a non-invasive blood pressure measurement method. The internal memory may also have stored therein a computer program which, when executed by the processor, causes the processor to perform a non-invasive blood pressure measurement method. The display screen of the computer equipment can be a liquid crystal display screen or an electronic ink display screen, the input device of the computer equipment can be a touch layer covered on the display screen, can also be keys, a track ball or a touch pad arranged on the shell of the computer equipment, and can also be an external keyboard, a touch pad or a mouse and the like.

It should be understood that, although the steps in the flowcharts of the embodiments of the present invention are shown in order as indicated by the arrows, these steps are not necessarily performed in order as indicated by the arrows. The steps are not strictly limited to the order of execution unless explicitly recited herein, and the steps may be executed in other orders. Moreover, at least some of the steps in various embodiments may include multiple sub-steps or stages that are not necessarily performed at the same time, but may be performed at different times, nor do the order in which the sub-steps or stages are performed necessarily performed in sequence, but may be performed alternately or alternately with at least a portion of the sub-steps or stages of other steps or other steps.

Those skilled in the art will appreciate that all or part of the processes in the methods of the above embodiments may be implemented by a computer program for instructing relevant hardware, where the program may be stored in a non-volatile computer readable storage medium, and where the program, when executed, may include processes in the embodiments of the methods described above. Any reference to memory, storage, database, or other medium used in embodiments provided herein may include non-volatile and/or volatile memory. The nonvolatile memory can include Read Only Memory (ROM), programmable ROM (PROM), electrically Programmable ROM (EPROM), electrically Erasable Programmable ROM (EEPROM), or flash memory. Volatile memory can include Random Access Memory (RAM) or external cache memory. By way of illustration and not limitation, RAM is available in a variety of forms such as Static RAM (SRAM), dynamic RAM (DRAM), synchronous DRAM (SDRAM), double Data Rate SDRAM (DDRSDRAM), enhanced SDRAM (ESDRAM), synchronous link (SYNCHLINK) DRAM (SLDRAM), memory bus (Rambus) direct RAM (RDRAM), direct memory bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM), among others.

The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above-described embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.

The foregoing examples illustrate only a few embodiments of the invention and are described in detail herein without thereby limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.

The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, and alternatives falling within the spirit and principles of the invention.

Claims

1. A non-invasive blood pressure measurement device for use in a non-invasive blood pressure measurement method, the non-invasive blood pressure measurement device comprising: the system comprises a pressing module, an information acquisition module, a characteristic identification module, a PTT calculation module and a blood pressure value output module;

The pressure applying module is used for changing the wall-crossing pressure of the arterial vessel at the cuff binding part, and the maximum value of the changed wall-crossing pressure is smaller than or equal to a first pressure threshold value;

The blood pressure value output module is used for determining the arterial diastolic pressure and the arterial systolic pressure of the subject according to the change trend of the pulse wave transmission time and outputting the arterial diastolic pressure and the arterial systolic pressure;

the step of identifying the second heart sound feature point in the heart sound information and identifying the descending isthmus feature point in the radial artery pulse wave information specifically comprises the following steps:

Identifying a first heart sound characteristic point in the heart sound information, and judging a second heart sound characteristic point according to the first heart sound characteristic point;

Identifying a descending isthmus feature point in the radial pulse wave information by taking the second heart sound feature point as an identification starting point;

In the step of identifying a second heart sound feature point in the heart sound information and identifying a descending isthmus feature point in the radial artery pulse wave information, denoising the heart sound information and the radial artery pulse wave information;

The step of determining the arterial diastolic pressure and the arterial systolic pressure of the subject according to the change trend of the pulse wave transmission time specifically comprises the following steps:

Dividing the change trend of pulse wave conduction time into a plurality of change curve segments;

Comparing curvatures of adjacent change curve sections, and marking the position corresponding to the wall-crossing pressure information when the curvatures are suddenly changed for the first time as a first pressure value to serve as arterial diastolic pressure; and marking the position corresponding to the wall-crossing pressure information when the curvature is subjected to the second abrupt change as a second pressure value, and taking the second pressure value as arterial systolic pressure.

2. The non-invasive blood pressure measurement device of claim 1, further comprising: the heart sound detection module, the radial artery detection module and the control module are electrically connected with the microprocessor;

3. The non-invasive blood pressure measurement device of claim 1, wherein the pressure application module comprises: a cuff and an air pressure sensor arranged in the cuff;

the cuff is internally provided with an air pressure cavity, the volume of the air pressure cavity is variable, and the air pressure sensor measures the arterial wall-crossing pressure of the cuff binding part by measuring the air pressure of the air pressure cavity;

the air pressure cavity is connected with an inflator pump, and the inflator pump is used for pressurizing the air pressure cavity;

The air pressure cavity is provided with an air valve, and the air valve is used for reducing pressure of the air pressure cavity.

4. The non-invasive blood pressure measurement device according to claim 2, further comprising: a display module;

The display module is electrically connected with the microprocessor and is used for displaying the detection information of the heart sound detection module, the detection information of the radial artery detection module and the blood pressure measurement result processed by the microprocessor;

the heart sound detection module is a stethoscope, and the radial artery detection module is a touch sensor.

5. A computer device comprising a memory and a processor, the memory having stored therein a computer program or instructions that, when executed by the processor, cause the processor to perform the steps of a non-invasive blood pressure measurement method comprising the steps of:

establishing a corresponding relation between the pulse wave conduction time and the wall-crossing pressure information, and generating a change trend of the pulse wave conduction time;

Determining the arterial diastolic pressure and the arterial systolic pressure of the subject according to the change trend of the pulse wave conduction time, and outputting the arterial diastolic pressure and the arterial systolic pressure;

6. A computer readable storage medium, wherein a computer program or instructions is stored on the computer readable storage medium, which when executed by a processor, causes the processor to perform the steps of a non-invasive blood pressure measurement method comprising the steps of: