CN116672427A - Natural plant volatile oil for relieving dizziness and headache as well as preparation method and application thereof - Google Patents

Abstract

The invention discloses volatile oil extracted from natural plants for relieving dizziness and headache, a preparation method and application thereof, and relates to the technical field of traditional Chinese medicines. The invention comprises largehead atractylodes rhizome oil, swordlike atractylodes rhizome oil, magnolia bark oil, szechuan lovage rhizome oil, safflower oil, saffron oil, angelica sinensis oil, dahurian angelica root oil, storax oil, costus root oil, nutgrass galingale rhizome oil, heavy sesame oil, sandalwood oil, pricklyash peel oil, benzoin oil, rhodiola root oil, ginseng oil, camphor tree bark oil, camphor tree leaf oil, eucalyptus oil, patchouli oil, nutmeg oil, danshen oil, rosewood oil, peppermint oil, ginger oil, perilla leaf oil, magnolia flower oil, grassleaf sweetflag oil, ginkgo leaf oil, old bark oil, rose oil, clove bud oil, cinnamon oil, fennel oil, star anise oil, clove basil oil, thyme oil, menthol, ethanol and vitamin E oil. Compared with the traditional decoction and Chinese patent medicine, the invention has the characteristics of high medicine carrying quantity, less impurities and multidimensional medicine administration, and has trans-epoch significance.

Description

A kind of volatile oil extracted from natural plants for alleviating dizziness and headache, its preparation method and application

technical field

The invention relates to the technical field of traditional Chinese medicine, and more specifically relates to a natural plant-extracted volatile oil for relieving dizziness and headache, a preparation method and application thereof.

Background technique

Traditional Chinese medicine has a long history, and the application of aromatic Chinese medicine and aromatherapy has a long history and rich clinical experience in China. Now, with the promulgation of the first part of the 2020 edition of "Chinese Pharmacopoeia", vegetable oils and extracts have become a separate chapter, and The corresponding implementation standards and testing methods have been clarified, but compared with the vigorous development of aromatherapy in the world, aromatherapy in my country is still stuck in the traditional medical decoction extraction method or the application of a single effective substance, lacking in the research and application of modern preparations.

With the vigorous development of China's economy, the competition in modern society is becoming increasingly fierce, the intensity of work and study is constantly increasing, and the pressure is intensifying. According to the epidemiological report of "Guidelines for Diagnosis and Treatment of Migraine in China (2022 Edition)", previous studies have shown that migraine in ordinary adults The incidence rate is 0-33/1000 cases, and the incidence rate of women is higher than that of men as a whole. In the peak age group, the incidence rate of women is 2-3 times that of men. A 2016 GBD study showed that the annual prevalence of migraine was 14.4%, with 18.9% in women and 9.8% in men. It is estimated that about 40 million people in China suffer from different degrees of headaches, often accompanied by symptoms such as nausea, vomiting, photophobia, phonophobia, and dizziness, which seriously affect life, work, and study.

According to the "Guidelines for Diagnosis and Treatment of Migraine in China (2022 Edition)", previous data in my country show that the diagnosis and treatment of migraine are still insufficient, and the patient visit rate is only 52.9%, and there are generally insufficient preventive treatment or excessive use of analgesic drugs and so on. There are wide-spread (extensive) demands in the clinic and in the market. According to the literature search, essential oils made of lavender, Roman chamomile and other plants are often used in the world to relieve tension headaches through aromatherapy. Treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) or acetaminophen was equally effective.

The mechanism of action of aromatherapy has been shown by modern studies that after the aroma substances absorbed into the nasal cavity are recognized and combined, an action potential is first generated, and then transmitted to the olfactory conduction pathway. Regarding the pathway of the olfactory pathway, previous studies have shown that aromatic molecules can specifically bind to G-protein coupled receptors on olfactory sensory neurons, eliciting olfactory receptor potentials, which are transmitted from olfactory sensory neurons to the olfactory bulb, and the olfactory bulb then transmits the signal Through the olfactory tract, it projects to the primary olfactory cortex, and then from the primary olfactory cortex to the secondary cortical center of the sense of smell, and finally to the hippocampus. Magnetic resonance studies have shown that the brain regions of the sense of smell are mainly located in the frontal and temporal lobes. The possible mechanism is that the aromatic substances inhaled into the human body can activate the relevant brain regions through the olfactory pathway, thereby achieving the functions of improving cognitive ability and regulating emotions. The results of the study confirmed this point of view, and further explored the connection between AD and olfaction and the possibility of inhalation therapy for AD. Wilson et al. conducted pathological and immunohistochemical examinations on AD patients and found that there was a significant correlation between the behavioral olfactory function test results and the severity of pathological changes caused by AD in the brain, which confirmed the relationship between AD and olfactory dysfunction. At the same time as the inner connection, it also shows the prospect of inhalation to treat diseases. On the other hand, after the aromatic substances enter the nasal cavity, they can also enter the blood circulation along with the gas exchange function of the lungs, so as to reach the corresponding target area and play a role. It is worth mentioning that different aroma substances activate different brain areas and target areas of the human body, and their functions are not exactly the same.

Therefore, it is an urgent problem for those skilled in the art to provide a natural plant-extracted volatile oil.

Contents of the invention

In view of this, the present invention provides a volatile oil extracted from natural plants for relieving dizziness and headache, its preparation method and application.

In order to achieve the above object, the present invention adopts the following technical solutions:

A kind of natural plant extraction volatile oil, in parts by weight, said volatile oil comprises the following components:

5-10 parts of Atractylodes atractylodes oil, 1-5 parts of Atractylodes atractylodes oil, 1-10 parts of magnolia oil, 5-10 parts of Chuanxiong oil, 1-3 parts of safflower oil, 1-3 parts of saffron oil, 5-10 parts of angelica oil , 1-5 parts of Angelica oil, 1-5 parts of Suhe sesame oil, 1-10 parts of woody oil, 1-10 parts of Cyperus oil, 1-5 parts of agarwood oil, 1-10 parts of sandalwood oil, 1-10 parts of Zanthoxylum bungeanum oil 2-10 parts of benzoin oil, 5-10 parts of rhodiola oil, 1-5 parts of ginseng oil, 1-5 parts of camphor bark oil, 10-15 parts of camphor leaf oil, 5-15 parts of eucalyptus (tree) oil , 5-10 parts of patchouli oil, 1-5 parts of nutmeg oil, 5-10 parts of salvia oil, 1-10 parts of frankincense oil, 5-10 parts of peppermint oil, 5-10 parts of peppermint oil, 5 parts of ginger oil -10 parts, perilla leaf oil 1-5 parts, magnolia flower oil 1-5 parts, calamus oil 1-5 parts, ginkgo biloba oil 5-10 parts, tangerine peel oil 1-5 parts, rose oil 1-5 parts , 5-15 parts of clove bud oil, 1-5 parts of clove leaf oil, 1-5 parts of cinnamon oil, 1-3 parts of cumin oil, 5-10 parts of star anise oil, 5-15 parts of clove basil oil, menthol 5-10 parts, 10-30 parts of ethanol, 5-10 parts of thyme oil (thyme oil), 1-5 parts of linalool thyme oil, 1 part of vitamin E oil.

Further, in parts by weight, the volatile oil includes 1-5 parts of flavoring agent;

The flavoring agent is any one of linalool thyme oil, Roman chamomile oil, jasmine essential oil, claret oil, and lavender oil.

Further, in parts by weight, the volatile oil includes the following components:

10 parts of Atractylodes atractylodes oil, 5 parts of Atractylodes atractylodes oil, 10 parts of magnolia bark oil, 10 parts of Chuanxiong oil, 1 part of safflower oil, 1 part of saffron oil, 10 parts of angelica oil, 5 parts of angelica oil, 5 parts of storax oil, and woody oil 10 parts, cyperus oil 10 parts, agarwood oil 2 parts, sandalwood oil 10 parts, pepper oil 10 parts, benzoin oil 10 parts, rhodiola oil 10 parts, ginseng oil 3 parts, camphor tree bark oil 5 parts, camphor tree leaf oil 10 parts, 10 parts of eucalyptus (tree) oil, 10 parts of patchouli oil, 5 parts of nutmeg oil, 10 parts of salvia oil, 10 parts of frankincense oil, 5 parts of peppermint oil, 10 parts of peppermint oil, 10 parts of ginger oil, 1 part perilla leaf oil, 5 parts magnolia flower oil, 5 parts calamus oil, 10 parts ginkgo leaf oil, 5 parts tangerine peel oil, 1 part rose oil, 10 parts clove bud oil, 2 parts clove leaf oil, 1 cinnamon oil 1 part cumin oil, 5 parts star anise oil, 10 parts clove basil oil, 5 parts menthol, 10 parts ethanol, 5 parts thyme oil (thyme oil), 3 parts linalool thyme oil, 1 part vitamin E oil .

A preparation method for extracting volatile oil from natural plants, comprising the following steps:

1) Angelica sinensis, Angelica dahurica, Zanthoxylum bungeanum, Saffron, Atractylodes macrocephala, Chuanxiong, safflower, Cyperus cyperi, Atractylodes atractylodis, Magnolia officinalis, Styrax, Agarwood, sandalwood, and benzoin in the formula amount are extracted by supercritical _CO2 :

Wash and pulverize the raw materials respectively, put them into the supercritical extraction kettle, cool the storage tank, and heat the extraction kettle and the analysis kettle at the same time to a temperature of 60-160°C, open the _CO2 cylinder to supply air, and turn on the high-pressure pump Pressurize the extraction kettle and the analysis kettle, and when the pressure reaches 5.0-30MPa, start circular extraction; adjust the flow rate, keep constant temperature and pressure at 60°C/5.0MPa, extract for 2 hours, extract the volatile oil and collect it in a packaging container for later use;

2) Ginseng, patchouli, nutmeg, mint, ginger, perilla leaf, tangerine peel, clove leaf, clove flower bud, cinnamon, cumin, star anise, rhodiola rosea, salvia miltiorrhiza, ginkgo leaf, camphor bark , camphor leaves, frankincense, magnolia flowers, eucalyptus leaves, calamus, roses, thyme, Roman chamomile, clove basil using steam distillation extraction process:

The raw materials are cleaned and crushed separately, placed in the distillation tank, injected with clean water, heated and pressurized by steam, 700-1400Pa, 100-120℃ boiling and vaporized to form an oil-water mixture; when the temperature continues to rise, the oil-water mixture evaporates rapidly, and then The steam of the mixture is generated, and the mixture of essential oil and water is obtained through the condenser. The essential oil floats on the water, and the oil and water are separated. Take the above essential oil to obtain volatile oil, put it into an aluminum bottle, seal it and store it in a cool place for later use;

3) Vitamin E (tocopheryl acetate) oil, jasmine essential oil, menthol, and 95% ethanol are purchased raw materials as additives; and an ethanol menthol solution is prepared and dissolved in a ratio of ethanol:menthol weight ratio of 2:1 Menthol is used for standby, that is, 10 parts of ethanol dissolves 5 parts of menthol. Menthol is in a crystal form. Menthol can be directly and completely dissolved in vegetable oil. The purpose of preparing ethanol menthol solution in advance is to reduce the stirring time and minimize the volatilization of volatile oil;

4) According to the liquid fluidity of the extracted volatile oil, add the volatile oil with better liquid fluidity to the closed upper and lower conical normal temperature stirring tank, and use the anchor type or frame type stirring head to avoid stirring heat and reduce the stirring contact surface;

The volatile oils with better fluidity of the liquid are: clove bud oil, clove leaf oil, pepper oil, Atractylodes macrocephala oil, Chuanxiong oil, safflower oil, woody oil, Cyperus oil, ginseng oil, patchouli oil, nutmeg oil, Peppermint Oil, Peppermint Oil, Ginger Oil, Perilla Leaf Oil, Tangerine Peel Oil, Cinnamon Oil, Cumin Oil, Star Anise Oil, Salvia Oil, Ginkgo Biloba Oil, Camphor Bark Oil, Camphor Leaf Oil, Magnolia Flower Oil, Eucalyptus oil, calamus oil, clove basil oil, rhodiola rosea oil, thyme oil (thyme oil), agarwood thyme oil;

5) Put the closed upper and lower conical mixing tank at room temperature, turn on the frequency conversion regulator, set the speed at 10rpm to ensure that the previously added oil-filled liquid is in a stirring state, and then add volatile oil with poor liquid fluidity from the upper feed port to avoid sticking of raw materials. viscous loss;

The volatile oils with poor fluidity of the liquid are: angelica oil, angelica oil, atractylodes oil, magnolia oil, vitamin E oil; after adding viscous oily raw materials, the stirring speed is set to 15-25 revolutions per minute (rpm), Stirring time is set at 45-60 minutes, since the volatile oils are all fat-soluble liquids, with good solubility and no precipitation and impurities; ensure that the heat generated by the equipment during the stirring process will not cause heat volatilization, resulting in reduced effects or increased production losses;

6) After stirring, turn on the frequency conversion regulator, set a lower speed, 10 revolutions per minute (rpm), add storax oil, agarwood oil, sandalwood oil, benzoin oil, saffron oil, frankincense oil, For the ethanol menthol solution, add the corresponding flavoring agent according to the desired fragrance type. Since the last added raw materials are all liquid-fluid raw materials, they are also fat-soluble, so there is no need to adjust the speed. The stirring time is 30 minutes. Stand still for 60 minutes, take a sample, the finished product should be bright brown, dark brown fluid liquid, no stratification after standing;

7) Transfer from the closed upper and lower conical normal temperature stirring tanks to the automatic filling equipment or the blowing-filling-sealing machine (BFS, Technical Guideline of Infusion Production of BlowFill Seal-BFS) through the pipeline. It also needs to stand for 30 minutes before it can be filled, and the filling speed and heat sealing speed should be controlled to reduce. Since the fat-soluble liquid itself has the physical characteristics of pipeline adhesion, there may be a problem of inaccurate dosage due to the loss of production pipeline equipment. The designed filling should be 105%-115% of the marked filling volume (adjusted according to the number and length of the filling head), should try to avoid the generation of air bubbles or the loss of the efficacy of the extracted essential oil due to production heat;

Filling in brown glass bottle with glass bead roll-on smear bottle, brown glass bottle spray bottle, nasal suction-ball massage dual-purpose frosted bottle, frosted transparent BFS single-time packaging, any one of the above Packed for use.

The application of the volatile oil extracted from a natural plant in the preparation of a medicine for relieving dizziness and headache.

Zanthoxylum oil/essential oil, Zanthoxylum bungeanum (ZANTHOXYLUM BUNGEANUM) fruit extract, the fruit of Rutaceae plants, using supercritical CO ₂ extraction method; after extraction, it is a brownish-yellow oily liquid with good fluidity; the functions are: warming the middle and relieving pain, Killing insects and relieving itching; TCM indications: used for spleen and stomach deficiency, cold pain in the abdomen, vomiting and diarrhea, roundworm abdominal pain, dental caries and toothache, vaginal itching, eczema and itching; modern research on this product also has: antioxidant effect, Antibacterial effect, so this product is also used as a natural antioxidant and preservative. Supervision level: raw materials can be added to food, health products (supplies), cosmetics, and medicines. In different embodiments, about 1-10 parts, the minimum amount of ingredients can have an effect, and the adjustment of the number of parts is only due to the different supervision levels, which leads to the influence of the proportion of other ingredients.

Saffron oil/essential oil, crocus (CROCUS SATIVUS) flower oil or crocus (CROCUS SATIVUS) extract, flower of Iridaceae plant, using supercritical _CO2 extraction method; after extraction, it is yellow to pale yellow oily liquid, The fluidity of the liquid is good; the functions are: promoting blood circulation and removing blood stasis, dispelling stagnation and resolving knots. Traditional Chinese Medicine Indications: Governance of worry and depression, fullness of chest and diaphragm, vomiting blood, typhoid fever, trance, women's amenorrhea, postpartum blood stasis and abdominal pain, tumbling and swelling. Supervision level: raw materials can be added to food, health products (supplies), cosmetics, and medicines. Since the food standard is only used as a flavoring agent, the implementation plan needs to adjust the dosage. For different embodiments, about 1-3 servings, the minimum amount of ingredients can have an effect, and the adjustment of the number of servings is only due to the different regulatory levels, resulting in the influence of the proportion of other ingredients.

Atractylodes Atractylodes Oil/Essential Oil, Atractylodes macrocephala (ATRACTYLODES MACROCEPHALA) rhizome extract, the stem of Compositae, extracted by supercritical _CO2 . After extraction, it is a brown-red oily liquid with good liquid fluidity; functions are: tonify qi and strengthen the spleen, dry dampness and diuresis, solidify the surface, stop sweating, and prevent miscarriage; Chinese medicine indications: fatigue and loss of appetite due to spleen and stomach qi deficiency , abdominal distension, loose stool, and even edema, difficulty urinating, soreness due to arthralgia due to dampness, spontaneous sweating due to surface deficiency, restless fetal movement. The modern study of this product also has the effect of improving memory; regulatory level: raw materials can be added to food, health products (supplies), cosmetics, and medicines. For different embodiments, about 5-10 parts, the minimum amount of ingredients can have an effect, and the adjustment of the number of parts is only due to the different supervision levels, which leads to the influence of the proportion of other ingredients.

Ligusticum chuanxiong oil/essential oil, Ligusticum chuanxiong (LIGUSTICUM CHUANXIONG) extract, the stem of Umbelliferae, extracted by supercritical _CO2 . After extraction, it becomes a brown-red oily liquid with good fluidity; its functions are: promoting blood circulation and promoting Qi, dispelling wind and relieving pain. Indications of traditional Chinese medicine are: used for chest pain and heart pain, chest and hypochondrium pain, tumbling swelling pain, irregular menstruation, amenorrhea dysmenorrhea, headache, rheumatic arthralgia. The modern study of this product also has: anti-inflammatory, antipyretic, sedative and other effects. Regulatory level: raw materials can be added to health care products (supplies), cosmetics, and medicines. For different embodiments, about 5-10 parts, the minimum amount of ingredients can have an effect, and the adjustment of the number of parts is only due to the different supervision levels, which leads to the influence of the proportion of other ingredients.

Safflower oil/essential oil, Safflower (CARTHAMUS TINCTORIUS) flower extract, flower of Compositae plant, extracted by supercritical _CO2 . After extraction, it is a yellow to light yellow oily liquid with good liquid fluidity; its effects are: promoting blood circulation and promoting menstrual flow, removing blood stasis and relieving pain. Indications of traditional Chinese medicine are: used for blood stasis dysmenorrhea, amenorrhea, postpartum lochia, abdominal pain due to stasis, lumps in the abdomen, chest pain and heart pain, bruises and bruises, hypochondriac pain due to stasis. The modern study of this product also has: the effect of treating frostbite, analgesic effect, and the effect on the nervous system. Regulatory level: raw materials can be added to health care products (supplies), cosmetics, and medicines. In different embodiments, about 1-3 servings, the minimum amount of ingredients can have an effect, and the adjustment of the number of servings is only due to the different regulatory levels, resulting in the influence of the proportion of other ingredients.

Saussurea oil/essential oil, Saussurea Lappa root extract, root of Asteraceae, extracted by supercritical _CO2 . After extraction, it becomes a brown-red oily liquid with good fluidity; its effects are: promoting blood circulation and relieving pain, invigorating the spleen and eliminating food. Indications of traditional Chinese medicine are: used for distending pain in the chest and hypochondrium, abdominal distention, heavy after diarrhea, indigestion persists, and lack of appetite. Regulatory level: raw materials can be added to health care products (supplies), cosmetics, and medicines. In different embodiments, about 1-10 parts, the minimum amount of ingredients can have an effect, and the adjustment of the number of parts is only due to the different supervision levels, which leads to the influence of the proportion of other ingredients.

Cyperus oil/essential oil, root extract of Cyperus rotundus, the root of Cyperaceae plant, extracted by supercritical _CO2 . After extraction, it becomes a brownish-yellow oily liquid with good fluidity; its effects are: soothing the liver and regulating qi, regulating menstruation and relieving pain. Indications of traditional Chinese medicine are: fullness in the chest and hypochondrium, abdominal distension and pain, cold colic abdominal pain, abdominal pain during menstruation, breast distension and pain, amenorrhea, soothing the liver and relieving stagnation, promoting qi to relieve pain. Regulatory level: raw materials can be added to health care products (supplies), cosmetics, and medicines. In different embodiments, about 1-10 parts, the minimum amount of ingredients can have an effect, and the adjustment of the number of parts is only due to the different supervision levels, which leads to the influence of the proportion of other ingredients.

Styrax oil/essential oil, Styrax (LIQUIDAMBARORIENTALIS) extract, resin of Hamamelisaceae plant, extracted by supercritical _CO2 . After extraction, it is brownish-yellow to dark brown oily liquid with good fluidity; the effects are: resuscitating, eliminating filth, and relieving pain. Indications of traditional Chinese medicine are: used for apoplexy with phlegm, sudden fainting, chest obstruction and heart pain, cold pain in the chest and abdomen, and epilepsy. Regulatory level: raw materials can be added to cosmetics and medicines. In different embodiments, about 1-5 servings, the minimum amount of ingredients can have an effect, and the adjustment of servings is only due to the different regulatory levels, resulting in the influence of the proportion of other ingredients.

Agarwood Oil/Essential Oil, Aquilariae (AQUILARIAE LIGNUMRESINATUM) Extract, wood block of Daphneaceae plant, extracted by supercritical _CO2 . After extraction, it is a light yellow to light yellowish brown oily liquid with good fluidity; its effects are: promoting qi and relieving pain, warming the middle to stop vomiting, invigorating qi and relieving asthma. Indications of traditional Chinese medicine are: used for distension and pain in the chest and abdomen, chills, vomiting, hiccups, kidney deficiency and dyspnea. The modern study of this product also has: antibacterial and analgesic effects. Regulatory level: raw materials can be added to cosmetics and medicines. In different embodiments, about 1-5 servings, the minimum amount of ingredients can have an effect, and the adjustment of servings is only due to the different regulatory levels, resulting in the influence of the proportion of other ingredients.

Sandalwood Oil/Essential Oil, Sandalwood (SANTALUM ALBUM) oil, wood block of a plant in the family Sandalaceae, extracted by supercritical _CO2 . After extraction, it is a golden yellow oily liquid with good fluidity; its effects are: dampness and sores, cough and sore throat, diuresis and stranguria, sedation and tranquilization, and pain relief. Indications of traditional Chinese medicine are: relieve stress, anxiety, nervous tension. Modern studies of this product also have: anti-depressant, anti-inflammatory, antispasmodic, and sedative effects. Regulatory level: raw materials can be added to cosmetics and medicines. In different embodiments, about 1-10 parts, the minimum amount of ingredients can have an effect, and the adjustment of the number of parts is only due to the different supervision levels, which leads to the influence of the proportion of other ingredients.

Benzoin oil/essential oil, benzoin (STYRAX BENZOIN) resin extract, resin of benzoin family plant, using supercritical CO ₂ extraction method. After extraction, it becomes a brownish-red oily liquid with good fluidity; its effects are: resuscitating the mind, promoting qi and blood circulation, and relieving pain. Indications of traditional Chinese medicine are: used for apoplexy with phlegm syncope, qi depression violent syncope, middle-evil coma, subordinate pain, postpartum haemorrhage, and convulsions in children. Regulatory level: raw materials can be added to cosmetics and medicines. In different embodiments, about 2-10 parts, the minimum amount of ingredients can have an effect, and the adjustment of the number of parts is only due to the different supervision levels, which leads to the influence of the proportion of other ingredients.

Angelica Oil/Essential Oil, Angelica (ANGELICA POLYMORPHASINENSIS) root extract, root of Umbelliferae, extracted by supercritical _CO2 . After extraction, it is a brownish-red viscous oily liquid with poor fluidity, only thick, and can be completely dissolved in lipid solvents. Efficacy: nourishing blood and promoting blood circulation, regulating menstruation and relieving pain, moistening intestines and laxative. Indications of traditional Chinese medicine are: for blood deficiency and chlorosis, dizziness and palpitations, irregular menstruation, amenorrhea dysmenorrhea, abdominal pain due to deficiency and cold, rheumatic arthralgia, bruises, dryness of the intestine and constipation. Supervision level: raw materials can be added to food, health products (supplies), cosmetics, and medicines. For different embodiments, about 5-10 parts, the minimum amount of ingredients can have an effect, and the adjustment of the number of parts is only due to the different supervision levels, which leads to the influence of the proportion of other ingredients.

Angelica dahurica oil/essential oil, medicine use (food can also use) Angelica dahurica (ANGELICA DAHURICA)) extract, health care products, cosmetics mainly use coastal angelica (ANGELICA KEISKEI) extract, both belong to the root of Umbelliferae plants, regulatory adjustments In consideration of safety, the supercritical _CO2 extraction method is adopted. After extraction, it is a brown-yellow or brown-red viscous oily liquid with poor fluidity, only thick, and can be completely dissolved in lipid solvents. Efficacy: dry dampness and invigorate the spleen, dispel wind and cold, improve eyesight. Indications of traditional Chinese medicine are: used for blood deficiency and chlorosis, irregular menstruation, spontaneous sweating, night sweats, hypochondriac pain, abdominal pain, and spasms of limbs. The modern study of this product also has: anti-inflammatory, antipyretic and analgesic, antispasmodic, antihypertensive, anti-radiation and other functions. Supervision level: raw materials can be added to food, health products (supplies), cosmetics, and medicines. In different embodiments, about 1-5 servings, the minimum amount of ingredients can have an effect, and the adjustment of servings is only due to the different regulatory levels, resulting in the influence of the proportion of other ingredients.

Atractylodes oil/essential oil, atractylodes (ATRACTYLODESCHINENSIS) rhizome extract, the rhizome of Compositae plants, extracted by supercritical _CO2 . After extraction, it is a brown-yellow to brown-red viscous oily liquid with poor fluidity, only thick, and can be completely dissolved in lipid solvents. Efficacy: dry dampness and eliminate phlegm, lower Qi and relieve fullness. Indications of traditional Chinese medicine are: used for damp resistance in the middle burner, abdominal fullness, diarrhea, edema, beriberi flaccidity, rheumatic arthralgia, wind-cold cold, night blindness, and dizziness and astringency. The modern study of this product also has: effects on the central nervous system, and a small dose is a sedative effect. Regulatory level: raw materials can be added to cosmetics and medicines. In different embodiments, about 1-5 parts, the minimum amount of ingredients can have an effect, and the adjustment of the number of parts is only due to the difference in the supervision level, which leads to the influence of the proportion of other ingredients.

The raw materials used in the supercritical _CO2 extraction process are roughly cleaned and crushed respectively, and put into the supercritical extraction kettle respectively, and the storage tank is cooled, and the extraction kettle and the analysis kettle are heated at the same time. When the specified temperature is reached (60-160°C), turn on the CO ₂ cylinder to supply air, and turn on the high-pressure pump to pressurize the extraction kettle and the analysis kettle. When the pressure reaches the set value (5.0-30MPa), the circulation extraction starts. At this time, adjust the flow rate and maintain a constant temperature Constant pressure (60°C/5.0MPa), the extraction time is 2 hours, and the extracted material is collected into a packaging container for future use.

Rhodiola rosea oil/essential oil, Rhodiola rosea (RHODIOLA ROSEA) extract or Rhodiola rosea (RHODIOLA ROSEA) root extract, the root of the Rhodiola rosea plant, extracted by steam distillation; after extraction, it is colorless to light Yellow oily liquid with good fluidity; efficacy: nourishing qi and clearing lung; improving intelligence and nourishing heart; reducing astringency to stop bleeding; dispelling blood stasis and reducing swelling. Indications of traditional Chinese medicine are: Deficiency of qi and weakness; chills after illness; shortness of breath and fatigue; cough due to lung heat; hemoptysis; leucorrhea diarrhea; bruises; burns; neurosis; altitude sickness, etc. Regulatory level: raw materials can be added to health care products (supplies), cosmetics, and medicines. For different embodiments, about 5-10 parts, the minimum amount of ingredients can have an effect, and the adjustment of the number of parts is only due to the different supervision levels, which leads to the influence of the proportion of other ingredients.

Clove bud oil/essential oil, clove (EUGENIA CARYOPHYLLUS) bud oil, flower buds of Myrtaceae plants, using steam distillation extraction process; after extraction, it is a light yellow oily liquid with good fluidity; the effect is: cooling in temperature Inverse, invigorating the kidney and supporting yang. Indications of traditional Chinese medicine are: used for spleen and stomach deficiency, hiccups and vomiting, lack of food, vomiting and diarrhea, cold pain in trusted subordinates, impotence due to kidney deficiency, and cold uterus. Modern research on this product also has pharmacological effects such as antibacterial, analgesic, and inflammation control. Supervision level: raw materials can be added to food, health products (supplies), cosmetics, and medicines. In different embodiments, about 5-15 parts, the minimum amount of ingredients can have an effect, and the adjustment of the number of parts is only due to the different supervision levels, which leads to the influence of the proportion of other ingredients.

Clove oil/essential oil, clove (EUGENIA CARYOPHYLLUS) leaf oil, leaves of Myrtaceae plants, using steam distillation extraction process; after extraction, it is a light yellow oily liquid with good fluidity; the efficacy is the same as that of traditional Chinese medicine. Clove bud oil, increase clove bud and clove leaf oil at the same time to ensure the content of chromone and flavonoids in clove, the main components of antibacterial and analgesic effects. Supervision level: raw materials can be added to food, health products (supplies), cosmetics, and medicines. In different embodiments, about 1-5 servings, the minimum amount of ingredients can have an effect, and the adjustment of servings is only due to the different regulatory levels, resulting in the influence of the proportion of other ingredients.

Ginseng oil/essential oil, ginseng (PANAX GINSENG) root extract, the root of Araliaceae Panax genus, is extracted by steam distillation; after extraction, it is a light yellow oily liquid with good fluidity; the effect is: great tonic Vitality, solidification and fluid production, soothes the nerves. Indications of traditional Chinese medicine are: treatment of fatigue and injury, lack of food, fatigue, nausea and vomiting, slippery stool, cough and shortness of breath, spontaneous sweating, palpitations, forgetfulness, dizziness and headache, impotence, frequent urination, thirst, women's collapse Leakage, chronic shock in children, and long-term deficiency, all signs of insufficiency of Qi, blood and body fluid. Supervision level: raw materials can be added to food, health products (supplies), cosmetics, and medicines. In different embodiments, about 1-5 servings, the minimum amount of ingredients can have an effect, and the adjustment of servings is only due to the different regulatory levels, resulting in the influence of the proportion of other ingredients.

Patchouli oil/essential oil, patchouli (POGOSTEMON CABLIN) oil, the whole plant of Labiatae, is extracted by steam distillation; after extraction, it is a brown-red oily liquid with good fluidity; the effect is: aromatization Turbidity, and stop vomiting, release summer heat. Indications of traditional Chinese medicine are: used for dampness and turbidity in the middle, nausea and vomiting, symptoms of summer heat and dampness, early onset of dampness and temperature, fever and fatigue, chest tightness and discomfort, cold and damp closure, abdominal pain, vomiting and diarrhea, and vomiting. The modern study of this product also has: antiseptic and antibacterial effects. Supervision level: raw materials can be added to food, health products (supplies), cosmetics, and medicines. For different embodiments, about 5-10 parts, the minimum amount of ingredients can have an effect, and the adjustment of the number of parts is only due to the different supervision levels, which leads to the influence of the proportion of other ingredients.

Nutmeg oil/essential oil, nutmeg (MYRISTICAFRAGRANS) kernel oil, the fruit of Zingiberaceae plants, is extracted by steam distillation; after extraction, it is a colorless to light yellow oily liquid with good fluidity; the effect is: dampness Promoting qi, warming the middle to stop vomiting, appetizing and eliminating food. Indications of traditional Chinese medicine are: used for dampness and turbidity, no desire to eat, chest and abdomen distension and pain, food accumulation, early onset of dampness and temperature, chest tightness without hunger, cold and damp vomiting. Supervision level: raw materials can be added to food, health products (supplies), cosmetics, and medicines. In different embodiments, about 1-5 servings, the minimum amount of ingredients can have an effect, and the adjustment of servings is only due to the different regulatory levels, resulting in the influence of the proportion of other ingredients.

Peppermint oil/essential oil, peppermint (MENTHA HAPLOCALYX) oil, the leaves of Labiatae plants, using steam distillation extraction process; after extraction, it is a light yellow oily liquid with good fluidity; the effect is: evacuate wind heat, clear away Boss, sore throat, rash, soothes the liver and promotes qi. Indications of traditional Chinese medicine are: used for wind-heat cold, early onset of wind-temperature, headache, red eyes, sore throat, aphtha, rubella, measles, chest and hypochondrium swelling. According to modern studies, this product also has: analgesic, antipruritic, anti-irritant, and bactericidal effects. Supervision level: raw materials can be added to food, health products (supplies), cosmetics, and medicines. For different embodiments, about 5-10 parts, the minimum amount of ingredients can have an effect, and the adjustment of the number of parts is only due to the different supervision levels, which leads to the influence of the proportion of other ingredients.

Peppermint oil/essential oil, peppermint (MENTHA PIPERITA) oil, the whole plant of Labiatae, using steam distillation extraction process; after extraction, it is a light yellow oily liquid with good fluidity; the medicinal effect of this product and The raw materials of peppermint oil/essential oil have the same function, and the main function of adding it alone is: to use as a cooling agent or a skin feel regulator. Supervision level: raw materials can be added to food, health products (supplies), cosmetics, and medicines. For different embodiments, about 5-10 parts, the minimum amount of ingredients can have an effect, and the adjustment of the number of parts is only due to the different supervision levels, which leads to the influence of the proportion of other ingredients.

Menthol/menthol, menthol (MENTHOL)/menthol (MENTHOLUM), due to the different extraction equipment, the steam distillation extraction process only extracts the volatile oil components in the plant peppermint, and its extraction wastewater-water-soluble is menthol (menthol Dew type), even if the second distillation, the number of bacteria-colonies in the circulating water does not meet the most stringent regulations (pharmaceutical grade requirements), so this product uses purchased raw materials, that is, separately purified menthol crystals, and its medical effects are similar to those of peppermint oil/ The raw materials of essential oils have the same function, and the main function of adding them alone is: to use as a cooling agent or a skin conditioner. Supervision level: raw materials can be added to food, health products (supplies), cosmetics, and medicines. Because it is a crystal, 95% ethanol or 96% bisdealdehyde ethanol (odorless ethanol) is used, and it is used as an ethanol menthol solution in a ratio of 2:1. Different embodiments, about 5-10 parts, the lowest composition The quantity has already played an effect, and the adjustment of the number of copies is only due to the different supervision levels, which leads to the influence of the proportion of other ingredients.

Ginger oil/essential oil, ginger (ZINGIBER OFFICINALE) root oil, the rhizome of Zingiber officinale, is extracted by steam distillation; after extraction, it is a light brown to light brown red oily liquid with good fluidity; the effect is: Expelling cold from the outside, warming the middle to stop vomiting, resolving phlegm and relieving cough. Indications of traditional Chinese medicine are: used for wind-cold cold, stomach-cold vomiting, cold phlegm and cough. According to modern scientific research, this product also has: antiemetic effect. Supervision level: raw materials can be added to food, health products (supplies), cosmetics, and medicines. For different embodiments, about 5-10 parts, the minimum amount of ingredients can have an effect, and the adjustment of the number of parts is only due to the different supervision levels, which leads to the influence of the proportion of other ingredients.

Perilla leaf oil/essential oil, perilla (PERILLA OCYMOIDES) leaf extract, leaves of Labiatae plants, using steam distillation extraction process; after extraction, it is a brownish-yellow oily liquid with good fluidity; the effect is: Expelling cold, promoting qi and stomach. Indications of traditional Chinese medicine are: used for wind-cold cold, cough and nausea, vomiting of pregnancy, fish and crab poisoning. According to modern studies, this product also has the functions of: improving memory and promoting the growth of brain nerve cell synapses. Supervision level: raw materials can be added to food, health products (supplies), cosmetics, and medicines. In different embodiments, about 1-5 servings, the minimum amount of ingredients can have an effect, and the adjustment of servings is only due to the different regulatory levels, resulting in the influence of the proportion of other ingredients.

Tangerine peel oil/essential oil, citrus (CITRUS RETICULATA) peel extract, the peel of Rutaceae plants, using steam distillation extraction process; after extraction, it is a colorless to light yellow oily liquid with good fluidity; the effect is: regulating qi, Adjusting the middle, drying dampness, resolving phlegm. Indications of traditional Chinese medicine are: treating fullness in the chest and abdomen, loss of appetite, vomiting and regurgitation, and cough with excess phlegm. Also detoxifies fish and crabs. Supervision level: raw materials can be added to food, health products (supplies), cosmetics, and medicines. In different embodiments, about 1-5 servings, the minimum amount of ingredients can have an effect, and the adjustment of servings is only due to the different regulatory levels, resulting in the influence of the proportion of other ingredients.

Cinnamon oil/essential oil, cinnamon (CINNAMOMUM CASSIA) extract or cinnamon (CINNAMOMUM CASSIA) bark extract, bark of Lauraceae plants, using steam distillation extraction process; after extraction, it is light brown to light yellow green oily liquid, The fluidity of the liquid is good; the effects are: replenishing fire and supporting yang, drawing fire back to its original state, dispelling cold and relieving pain, and warming the meridians. Indications of traditional Chinese medicine are: cold impotence, cold pain in waist and knees, cold pain in trusted subordinates, sweating due to sweating, vomiting and diarrhea, cold colic, abdominal pain, dysmenorrhea, amenorrhea, arthralgia due to cold and dampness, bleeding from yin gangrene, panting due to kidney deficiency, rising and falling due to deficiency of yang, dizziness Muchi. According to modern studies, this product also has the functions of sterilization, sedation, antipyretic and anticonvulsant. Supervision level: raw materials can be added to food, health products (supplies), cosmetics, and medicines. In different embodiments, about 1-5 servings, the minimum amount of ingredients can have an effect, and the adjustment of servings is only due to the different regulatory levels, resulting in the influence of the proportion of other ingredients.

Fennel oil/essential oil, fennel (FOENICULUM VULGARE) oil, the seed of Umbelliferae, is extracted by steam distillation; after extraction, it is a light yellow oily liquid with good fluidity; the effects are: dispelling cold and relieving pain, regulating qi and stomach. Indications of traditional Chinese medicine are: cold colic, abdominal pain, testicular prolapse, dysmenorrhea, cold pain in the lower abdomen, distension and pain in the abdomen, and hematemesis due to lack of food. According to modern research, this product also has: antibacterial effect, especially against fungal spores, Mycobacterium avium tuberculosis, and Staphylococcus aureus. Supervision level: raw materials can be added to food, health products (supplies), cosmetics, and medicines. In different embodiments, about 1-3 servings, the minimum amount of ingredients can have an effect, and the adjustment of the number of servings is only due to the different regulatory levels, resulting in the influence of the proportion of other ingredients.

Star anise oil/essential oil, star anise (ILLICIUM VERUM) oil or star anise (ILLICIUM VERUM) fruit/seed oil, seeds of Magnoliaceae plants, using steam distillation extraction process; after extraction, it is light yellow oily liquid, liquid fluidity Better; the effects are: warming yang and expelling cold, regulating and harmonizing the stomach, regulating qi and relieving pain. Indications of traditional Chinese medicine are: used for cold colic abdominal pain, cold waist and knee pain, stomach cold vomiting, abdominal pain. According to modern scientific research, this product also has: antibacterial effect, analgesic effect, and antioxidant effect. Supervision level: raw materials can be added to food, health products (supplies), cosmetics, and medicines. For different embodiments, about 5-10 parts, the minimum amount of ingredients can have an effect, and the adjustment of the number of parts is only due to the different supervision levels, which leads to the influence of the proportion of other ingredients.

Salvia miltiorrhiza oil/essential oil, root extract of salvia miltiorrhiza (SALVIA MILTIORRHIZA), the root of Labiatae, steam distillation extraction process; after extraction, it is light brown-red to light yellow-green oily liquid with good fluidity; efficacy: blood circulation Dispelling blood stasis, promoting menstrual flow and relieving pain, clearing away heart-fire and relieving restlessness, cooling blood and eliminating carbuncle. Indications of traditional Chinese medicine are: used for chest pain and heartache, epigastric and hypochondriac pain, accumulation of lumps in the abdomen, heat arthralgia pain, upset and insomnia, irregular menstruation, dysmenorrhea and amenorrhea, and traumatic injuries. Regulatory level: raw materials can be added to health care products (supplies), cosmetics, and medicines. For different embodiments, about 5-10 parts, the minimum amount of ingredients can have an effect, and the adjustment of the number of parts is only due to the different supervision levels, which leads to the influence of the proportion of other ingredients.

Ginkgo biloba oil/essential oil, Ginkgo biloba (GINKGO BILOBA) leaf extract, leaves of Ginkgoaceae plants, steam distillation extraction process; after extraction, it is a colorless to light yellow oily liquid with good fluidity; efficacy: beneficial to the heart Constricting the lung, dispelling dampness and stopping diarrhea. Indications of traditional Chinese medicine are: controlling chest tightness and heartache, palpitations, cough with phlegm, dysentery, and leucorrhea. According to modern scientific research, this product also has the following functions: it can relieve the symptoms of cerebral hypoxia. Regulatory level: raw materials can be added to health care products (supplies), cosmetics, and medicines. In different embodiments, about 1-5 servings, the minimum amount of ingredients can have an effect, and the adjustment of servings is only due to the different regulatory levels, resulting in the influence of the proportion of other ingredients.

Camphor bark oil/essential oil, camphor (CINNAMOMUM CAMPHORA) bark oil, the bark of the Lauraceae plant camphora, extracted by steam distillation; after extraction, it is a colorless to light yellow oily liquid with good fluidity; the effect is: Opening the orifices and warding off the dirty, warming the middle-Jiao to relieve pain, promoting dampness and killing parasites. Indications of traditional Chinese medicine are: used for cold-damp vomiting and diarrhea, stomach and abdomen pain, beriberi, bruises, scabies, dental caries and pain. Raw materials can be added to cosmetics and medicines, and the dosage needs to be adjusted in the implementation plan. Cosmetics and pharmaceuticals can add raw materials. In different embodiments, about 1-5 servings, the minimum amount of ingredients can have an effect, and the adjustment of servings is only due to the different regulatory levels, resulting in the influence of the proportion of other ingredients.

Camphor tree leaf oil/essential oil, camphor tree (CINNAMOMUM CAMPHORA) leaf extract, the leaves of the family plant CAMPHORA, steam distillation extraction process; after extraction, it is a light yellow oily liquid with good fluidity; the functions and indications of this product are consistent with camphor bark The purpose of using this product and the above-mentioned camphor bark oil is mainly to replace the camphor of the drug standard, and the camphor is a granule formed by distillation and refining of the root, trunk, branch and leaf of Cinnamomumcamphora (L.) Presl. thing. The drug grade can be used normally, but considering the slight toxicity of camphor (the theory of camphor in traditional Chinese medicine: pungent; hot; slightly toxic; modern medicine believes that it has mucosal irritation), it is adjusted to the internationally evaluated safer camphor bark and leaves as Raw materials, first remove the roots and stems with higher content of dichlorobenzene and naphthalene. Cosmetics and pharmaceuticals can add raw materials. In different embodiments, about 10-15 parts, the minimum amount of ingredients can have an effect, and the adjustment of the number of parts is only due to the different supervision levels, which leads to the influence of the proportion of other ingredients.

Frankincense oil/essential oil, frankincense (BOSWELLIA CARTERII) oil, olive plant resin, steam distillation extraction process; after extraction, it is a colorless to light yellow oily liquid with good fluidity; effects: promoting blood circulation, relieving pain, reducing swelling muscle growth. Indications of traditional Chinese medicine are: for chest pain and heartache, epigastric pain, dysmenorrhea amenorrhea, postpartum stasis, rheumatic arthralgia. According to modern studies, this product also has the functions of calming the nerves, calming the nerves, relieving pain, reducing inflammation, and antibacterial. Cosmetics and pharmaceuticals can add raw materials. In different embodiments, about 1-10 parts, the minimum amount of ingredients can have an effect, and the adjustment of the number of parts is only due to the different supervision levels, which leads to the influence of the proportion of other ingredients.

Magnolia flower oil/essential oil, MAGNOLIA BIONDII flower extract, magnolia flower, steam distillation extraction process; after extraction, it is a light yellow oily liquid with good fluidity; the effect is: dispelling wind and cold, dredging nose orifice. Indications of traditional Chinese medicine are: used for wind-cold headache, nasal congestion, runny nose, rhinorrhea, and nasal sinusitis. According to modern studies, this product also has: local astringent, antibacterial, anti-inflammatory, analgesic, striated muscle relaxation, and anti-allergic effects. Cosmetics and pharmaceuticals can add raw materials. In different embodiments, about 1-5 servings, the minimum amount of ingredients can have an effect, and the adjustment of servings is only due to the different regulatory levels, resulting in the influence of the proportion of other ingredients.

Eucalyptus (leaf) oil/essential oil, blue eucalyptus (EUCALYPTUS GLOBULUS) leaf oil or blue eucalyptus (EUCALYPTUS GLOBULUS) oil, the pharmacopoeia name is: eucalyptus oil, the leaves of blue eucalyptus of Myrtaceae plant, steam distillation extraction process; after extraction, It is a colorless to pale yellow oily liquid with good fluidity; its effects are: dispelling wind and relieving exterior syndrome, clearing heat and detoxification, reducing phlegm and regulating qi, killing insects and relieving itching. Indications of traditional Chinese medicine are: cold, high fever, wheezing, whooping cough, abdominal pain, diarrhea, dysentery, hook, filariasis, malaria, rheumatism, eczema, mange, burns, traumatic bleeding. Cosmetics and pharmaceuticals can add raw materials. In different embodiments, about 5-15 parts, the minimum amount of ingredients can have an effect, and the adjustment of the number of parts is only due to the different supervision levels, which leads to the influence of the proportion of other ingredients.

Calamus calamus oil/essential oil, calamus calamus (ACORUS CALAMUS) root extract, root of Araceae plants, steam distillation extraction process; after extraction, it is light yellow oily liquid with good fluidity; efficacy: resuscitating phlegm, awakening God puzzles, eliminates dampness and appetizes. Indications of traditional Chinese medicine are: used for coma and epilepsy, forgetfulness and insomnia, tinnitus and deafness, abdominal pain without hunger, and dysentery. Cosmetics and pharmaceuticals can add raw materials. In different embodiments, about 1-5 servings, the minimum amount of ingredients can have an effect, and the adjustment of servings is only due to the different regulatory levels, resulting in the influence of the proportion of other ingredients.

Clove basil oil/essential oil, basil (OCIMUM BASILICUM) oil, the pharmacopoeia name is: clove basil oil, the whole plant of Labiatae, extracted by steam distillation; after extraction, it is light yellow oily liquid with good fluidity; Efficacy: local analgesia, antiseptic. Indications of traditional Chinese medicine are: use to treat dental caries, etc. A dual-purpose ingredient that, in addition to topical pain relief, also acts as a natural antiseptic. Cosmetics and pharmaceuticals can add raw materials. In different embodiments, about 5-15 parts, the minimum amount of ingredients can have an effect, and the adjustment of the number of parts is only due to the different supervision levels, which leads to the influence of the proportion of other ingredients.

Rose essential oil, Turkic rose (ROSA DAMASCENA) flower oil, the flower of Rosaceae, is extracted by steam distillation; after extraction, it is a light yellow oily liquid with good fluidity; its effects are: regulating qi and relieving stagnation, and dispelling blood stasis . Traditional Chinese medicine is mainly used to treat liver and stomach pain, Xinjiu wind arthralgia, hematemesis and hemoptysis, irregular menstruation, red and white vaginal discharge, dysentery, breast abscess, and swollen toxin. Dual-purpose ingredients, in addition to the efficacy of traditional Chinese medicine, are also used as flavoring (correcting) agents/fragrances. Supervision level: raw materials can be added to food, health products (supplies), cosmetics, and medicines. In different embodiments, about 1-5 servings, the minimum amount of ingredients can have an effect, and the adjustment of servings is only due to the different regulatory levels, resulting in the influence of the proportion of other ingredients.

Thyme oil/essential oil, thyme (THYMUS VULGARIS) flower/leaf/stem extract, steam distillation extraction process; after extraction, it is a colorless transparent to light yellow oily liquid with good liquid fluidity; The extract and thymol are regulated under the same conditions, so the pharmacological effects of thymol extract are: the bactericidal effect of thymol is stronger than that of phenol, and its toxicity is low. Antiseptic and local anesthetic, used for disinfection and sterilization of the mouth and throat, dermatophytosis, actinomycosis and otitis. It can promote the movement of tracheal cilia, which is beneficial to the secretion of tracheal mucus. It is easy to eliminate phlegm and has a bactericidal effect, so it can be used to treat bronchitis and whooping cough. Supervision level: raw materials can be added to food, health products (supplies), cosmetics, and medicines. For different embodiments, about 5-10 parts, the minimum amount of ingredients can have an effect, and the adjustment of the number of parts is only due to the different supervision levels, which leads to the influence of the proportion of other ingredients.

Linalool thyme oil/essential oil, thyme (THYMUS VULGARIS) flower/leaf oil, steam distillation extraction process; after extraction, it is a colorless transparent to light yellow oily liquid with good fluidity; this ingredient is a dual-purpose ingredient, It is used as flavoring (correcting) agent/fragrance agent, and enhances the taste of agarwood. It is mainly agarwood alcohol with the extract of agarwood. It is used in a specific fragrance type (model) and the proportion is relatively low. The ratio of each embodiment is 1-5 parts.

Roman chamomile oil/essential oil, white flower chamomile (ANTHEMIS NOBILIS) flower oil, steam distillation extraction process; after extraction, it is a light blue to light yellow oily liquid with good fluidity; this ingredient is mainly used for adjustment (correction) Flavoring agents/fragrances are used, and specific fragrance types (models) are used, and the proportion is relatively low. The ratio of each embodiment is 1-5 parts.

Clary perilla oil/essential oil, sage (SALVIA JAPONICA) extract, steam distillation extraction process; after extraction, it is a light yellow oily liquid with good fluidity; this ingredient is mainly used for flavoring (correcting) agents/ Fragrances are used, and specific fragrance types (models) are used, and the proportion is relatively low. The ratio of each embodiment is 1-5 parts.

Lavender oil/essential oil, lavender (LAVANDULA ANGUSTIFOLIA) flower/leaf/stem extract or lavender (LAVANDULA ANGUSTIFOLIA) flower extract, steam distillation extraction process; after extraction, it is a light yellow oily liquid with good fluidity; this ingredient It is mainly used as a flavoring (correcting) agent/fragrance, and the floral fragrance covers up other fragrances and is obviously not added as a basic formula. It is used in a specific fragrance type (model) and the proportion is relatively low. The ratio of each embodiment is 1-5 parts.

The raw materials and plants that are extracted by steam distillation are roughly cleaned and roughly crushed, respectively placed in distillation tanks, injected with clean water, heated and pressurized by steam (700-1400Pa), boiled (100-120°C) and vaporized to form oil and water The mixture, when the temperature continues to rise, the oil-water mixture evaporates rapidly, and then the steam of the mixture is generated, and the mixture of essential oil and water is obtained through the condenser. The essential oil floats on the water, separates the oil and water, takes the above essential oil, puts it into an aluminum bottle and seals it Store in a cool place for later use.

Jasmine oil/essential oil, jasmine (JASMINUM SAMBAC) flower oil, flower of Oleaceae plant, the standard of Chinese medicine decoction pieces is dried flower, and it is difficult to extract volatile oil components. This component is mainly used for flavoring (correcting) agent/fragrance, specific fragrance type (Model) used, the proportion is relatively low, and the floral fragrance covers up other fragrances, so it is obviously not added as a basic formula, so the purchased food or pharmaceutical grade raw materials are used. This raw material also has a certain effect of traditional Chinese medicine, and the effects are: regulating qi, dispelling depression, neutralizing, and warding off foulness. Indications of traditional Chinese medicine are: used for chest and diaphragm discomfort, diarrhea and abdominal pain, dizziness and headache, conjunctival congestion, and sores. Supervision level: raw materials can be added to food, health products (supplies), cosmetics, and medicines. The ratio of each embodiment is 1-5 parts.

Vitamin E oil, Vitamin E/Tocopheryl Acetate (TOCOPHERYL ACETATE), is used as a fat-soluble natural antioxidant and stabilizer, so it uses purchased food or pharmaceutical grade raw materials. Management level: raw materials can be added to food, health care products (supplies), cosmetics, and medicines, and no dosage adjustment is required for each implementation plan. The proportion of each embodiment is 1 part, about 0.06%-0.8% content.

It can be seen through the above-mentioned technical scheme that, compared with the prior art, the beneficial effects of the present invention are:

Theoretical basis of traditional Chinese medicine prescriptions: the formula science model of the present invention follows the theory of "junchenzuoshi" in traditional Chinese medicine prescriptions. As early as the Song Dynasty, similar prescriptions appeared and were used in clinical practice. A total of 82 articles were published with this similar prescription model TCM decoction , Japanese and Korean Chinese authors of English international journals have also published 39 articles, all of which can prove that this formula has therapeutic significance; Substance-volatile oil realizes this prescription model, and some modern researches consider slightly toxic substances to be eliminated (or replaced) through the prescription. Transdermal absorption, inhalation of bromine administration) characteristics, has trans-epochal significance.

Modern medical pharmacology basis:

Modern medical treatment of headache and dizziness generally also adopts analgesia, improvement of cerebrovascular blood flow and neurotransmitter receptor (dopamine, 5-hydroxytryptamine) levels and other programs, combined with multi-drug compound prescriptions, to treat primary (or intractable) biases. Headache. The modern research on some medicines that have been marked in the detailed formula of the present invention shows that the prescription ingredients of the present invention have better antispasmodic and analgesic effects, improved cerebral blood flow, and sedative effects. The active substances officially included in the Pharmacopoeia have a clear mechanism of action and have been clinically verified.

In addition, the active ingredients of aromatic plants (Chinese medicine) such as woody lactone and dehydro-woody lactone in woody, have good antibacterial, analgesic and antiviral activities; another example is the main active substance 6-zingiberene in ginger Phenol, 6-gingerol, 8-gingerol, 10-gingerol, etc. have good anti-oxidation, anti-inflammatory, and anti-rheumatic effects. These effective substances are all based on aromatic lipids or aromatic lipids (hydrogen on the aromatic ring A class of aromatic compounds substituted by hydroxyl) exists in the form and plays a role. The volatile oil component-aromatic compound is the best form of administration, and the physical properties should be like this. At present, soft capsule preparations are used for volatile oil in Chinese patent medicines. When administered through the gastrointestinal tract, gastric acid and digestive enzymes destroy the aromatic ring structure, which greatly affects the efficacy of the medicine; In order to exert its medicinal effect, the adjustment and invention of the dosage form is a milestone in the scientific research of natural medicines.

Description of drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description are only It is an embodiment of the present invention, and those skilled in the art can also obtain other drawings according to the provided drawings without creative work.

Accompanying drawing of Fig. 1 is vitamin E oil quality inspection report of the present invention;

Accompanying drawing of Fig. 2 is jasmine essential oil quality inspection report of the present invention;

Accompanying drawing of Fig. 3 is menthol quality inspection report of the present invention.

Detailed ways

The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

Example 1:

1) Take Angelica, Angelica dahurica, Zanthoxylum bungeanum, Saffron, Atractylodes macrocephala, Rhizoma Chuanxiong, Safflower, Woody, Rhizoma Cyperi, Atractylodes atractylodes, Magnolia officinalis, Styrax, Agarwood, Sandalwood, Benzoin, through the supercritical _CO2 extraction process, the composition ratio, The content is calculated according to the weight of the extract after extraction.

2) The operation of the supercritical _CO2 extraction process is as follows: the plants are roughly cleaned and coarsely crushed, respectively put into the supercritical extraction kettle, the storage tank is cooled, and the extraction kettle and the analysis kettle are heated at the same time. When the specified temperature ( 100°C), turn on the CO ₂ gas cylinder to supply air, and turn on the high-pressure pump to pressurize the extraction kettle and the analysis kettle. When the pressure reaches the set value (20MPa), the circular extraction starts. At this time, adjust the flow rate and maintain constant temperature and pressure (60°C /5.0MPa), the extraction time is 2 hours, and the extracted material is collected into a packaging container for future use.

3) Take ginseng, patchouli, nutmeg, mint leaves, mint whole plant, ginger, perilla leaves, tangerine peel, clove buds, clove leaves, cinnamon, cumin, star anise, rhodiola rosea, salvia, ginkgo leaves, Camphor tree bark, camphor tree leaves, frankincense, magnolia flower, eucalyptus leaves, calamus, rose, thyme, Roman chamomile, and clove basil are extracted by steam distillation. The ratio and content of ingredients are calculated by the weight of the extracted extract.

4) The operation of the steam distillation extraction process is as follows: the plants are roughly cleaned and roughly crushed, respectively placed in the distillation tank, injected with clean water, heated and pressurized by steam (1000Pa), boiled (110°C) and vaporized to form an oil-water mixture. As the temperature continues to rise, the oil-water mixture evaporates rapidly, and the steam of the mixture is generated, and the mixture of essential oil and water is obtained through the condenser. The essential oil floats on the water, separates the oil and water, takes the above essential oil, puts it into an aluminum bottle, and stores it in a cool place. place, spare.

5) Vitamin E (tocopheryl acetate) is used as a stabilizer and an additive is an outsourced raw material; menthol and 95% ethanol are used as a skin feel regulator (cool feeling) and then an outsourced raw material; and an ethanol menthol solution is configured, Dissolve menthol with ethanol at a ratio of 2:1 for later use, that is, dissolve 5 parts of menthol in 10 parts of ethanol. Menthol is in a crystal form, and menthol can be directly and completely dissolved in vegetable oil. The purpose of preparing ethanol menthol solution in advance is to reduce the stirring time. Reduce the evaporation of volatile oil as much as possible.

6) Firstly, it is distinguished according to the liquid fluidity of the extracted volatile oil, and the raw materials with better liquid fluidity are first added to the closed upper and lower conical normal temperature stirring tank, and the anchor type or frame type stirring head is used to avoid stirring heat and reduce stirring contact The raw materials that can be added for the first time are: 10 parts of Atractylodes macrocephala oil, 10 parts of Chuanxiong oil, 1 part of safflower oil, 10 parts of woody oil, 10 parts of Cyperus cyperus oil, 10 parts of Zanthoxylum bungeanum oil, 10 parts of Rhodiola rosea oil, ginseng oil 3 parts, 5 parts of camphor bark oil, 10 parts of camphor leaf oil, 10 parts of eucalyptus (tree) oil, 10 parts of patchouli oil, 5 parts of nutmeg oil, 10 parts of salvia oil, 5 parts of peppermint oil, 10 parts of peppermint oil 10 parts of ginger oil, 1 part of perilla leaf oil, 5 parts of magnolia flower oil, 5 parts of calamus oil, 10 parts of ginkgo leaf oil, 5 parts of tangerine peel oil, 10 parts of clove bud oil, 2 parts of clove leaf oil, cinnamon 1 part oil, 1 part cumin oil, 5 parts star anise oil, 10 parts clove basil oil, 5 parts thyme oil (thyme oil), 3 parts linalool thyme oil;

7) Put the closed upper and lower conical stirring tank at room temperature, turn on the frequency conversion regulator, set the lower speed, 10 revolutions per minute (rpm) to ensure that the previously added oil liquid is in a stirring state, and then add the liquid flow from the upper feed port The extraction of volatile oil is poor, avoiding the sticky loss of raw materials; the raw materials added in the second step are: 5 parts of atractylodes oil, 10 parts of magnolia oil, 10 parts of angelica oil, 5 parts of angelica oil, and 1 part of vitamin E oil; increase the viscous oiliness After the raw materials, the stirring speed is set to 20 revolutions per minute (rpm), and the stirring time is set to 50 minutes. Since the raw materials are all fat-soluble liquids, they have good solubility and no precipitation and impurities; Heat, resulting in heat volatilization, reduced effectiveness or increased production loss.

8) After the second step of stirring is completed, turn on the frequency conversion regulator, set a lower speed, 10 revolutions per minute (rpm), and finally add 1 part of saffron oil, 5 parts of storax oil, and 2 parts of agarwood oil from the upper feeding port. 10 parts of benzoin oil, 10 parts of sandalwood oil, 10 parts of benzoin oil, 10 parts of frankincense oil, 1 part of rose oil, and 15 parts of ethanol menthol solution prepared in advance. The raw materials are also fat-soluble, and there is no need to adjust the speed. The stirring time is 30 minutes. After the stirring is completed, let it stand for 60 minutes, and take a sample. The finished product should be bright brown or dark brown liquid liquid, and it should not be separated after standing.

9) Transfer from the closed upper and lower conical normal temperature stirring tanks to the automatic filling equipment or blowing-filling-sealing integrated machine (BFS, Technical Guideline of Infusion Production of BlowFill Seal-BFS) through pipelines. It also needs to stand for 30 minutes before it can be filled, and the filling speed and heat sealing speed should be controlled to reduce. Since the fat-soluble liquid itself has the physical characteristics of pipeline adhesion, there may be a problem of inaccurate dosage due to the loss of production pipeline equipment. The designed filling should be 105%-115% of the marked filling capacity (adjusted according to the number and length of the filling head), should try to avoid the generation of air bubbles or the loss of the efficacy of the extracted essential oil due to production heat.

10) Filling is a brown glass bottle with glass beads for smearing, or a brown glass bottle for spraying medication, or a dual-purpose frosted bottle for nasal suction and rolling ball massage, or a single-use package in a frosted transparent BFS package. Packed for use.

11) The present invention is a form of Chinese patent medicine for external use. It has the characteristics of high skin safety, high drug loading capacity of active ingredients in the same volume, easy to carry, and high compliance of patients with medication. It can relieve symptoms caused by colds by cooperating with specific acupuncture points of traditional Chinese medicine and massage and smearing balls. headache, tension headache, vascular headache or nausea, vomiting, dizziness and other symptoms caused by headache.

Example 2:

1) Take Angelica, Angelica dahurica, Zanthoxylum bungeanum, Saffron, Atractylodes macrocephala, Rhizoma Chuanxiong, Safflower, Woody, Rhizoma Cyperi, Atractylodes atractylodes, Magnolia officinalis, Styrax, Agarwood, Sandalwood, Benzoin, through the supercritical _CO2 extraction process, the composition ratio, The content is calculated according to the weight of the extract after extraction.

2) The extraction kettle and the desorption kettle reach the specified temperature (60° C.), and the pressure reaches the set value (5.0 MPa); the rest of the extraction process is the same as in Example 1.

3) Take ginseng, patchouli, nutmeg, mint leaves, whole mint plants, ginger, perilla leaves, tangerine peel, cloves, cinnamon, cumin, star anise, rhodiola rosea, salvia miltiorrhiza, ginkgo leaves, camphor bark, Camphor tree leaves, frankincense, magnolia flower, eucalyptus leaves, calamus, rose, thyme, Roman chamomile, and clove basil are extracted by steam distillation. The proportion and content of ingredients are calculated according to the weight of the extracted extract.

4) Heating and pressurizing (700 Pa) by steam, boiling (100° C.) and vaporizing to form an oil-water mixture, and the rest of the extraction process is the same as in Example 1.

5) Vitamin E (tocopheryl acetate), jasmine oil/essential oil are used as stabilizers, additives, flavoring (correcting) agents are purchased raw materials; menthol and 95% ethanol are used as skin feel regulators (cooling) It is an externally purchased raw material; and configure ethanol menthol solution, dissolve menthol in a ratio of 2:1 with ethanol for later use, that is, 10 parts of ethanol dissolve 5 parts of menthol, menthol is in a crystal form, and menthol can be directly and completely dissolved in vegetable oil. The purpose of configuring the ethanol menthol solution in advance is to reduce the stirring time and minimize the volatilization of volatile oil.

6) Firstly, it is distinguished according to the liquid fluidity of the extracted volatile oil, and the raw materials with better liquid fluidity are first added to the closed upper and lower conical normal temperature stirring tank, and the anchor type or frame type stirring head is used to avoid stirring heat and reduce stirring contact The raw materials that can be added for the first time are: 10 parts of Atractylodes macrocephala oil, 5 parts of Chuanxiong oil, 2 parts of safflower oil, 10 parts of woody oil, 10 parts of Cyperus oil, 5 parts of Zanthoxylum bungeanum oil, 10 parts of rhodiola oil, ginseng oil 2 parts, camphor tree bark oil 5 parts, camphor tree leaf oil 10 parts, eucalyptus (tree) oil 5 parts, patchouli oil 10 parts, nutmeg oil 2 parts, salvia oil 10 parts, peppermint oil 5 parts, peppermint oil 5 parts 5 parts of ginger oil, 3 parts of perilla leaf oil, 5 parts of magnolia flower oil, 1 part of calamus oil, 10 parts of ginkgo leaf oil, 3 parts of tangerine peel oil, 10 parts of clove bud oil, 2 parts of clove leaf oil, cinnamon 3 parts oil, 2 parts cumin oil, 5 parts star anise oil, 5 parts clove basil oil, 1 part thyme oil (thyme oil), 1 part linalool thyme oil.

7) Put the closed upper and lower conical stirring tank at room temperature, turn on the frequency conversion regulator, set the lower speed, 10 revolutions per minute (rpm) to ensure that the previously added oil liquid is in a stirring state, and then add the liquid flow from the upper feed port Extract volatile oil with poor performance to avoid sticky loss of raw materials; the raw materials added in the second step are: 2 parts of atractylodes oil, 2 parts of magnolia oil, 5 parts of angelica oil, 5 parts of angelica oil, and 1 part of vitamin E oil; increase the viscous oiliness After raw materials, set the stirring speed to 15-25 revolutions per minute (rpm), and the stirring time to 45-60 minutes. Since the raw materials are all fat-soluble liquids, they have good solubility and no precipitation or impurities; ensure that the stirring process It does not cause heat volatilization due to the heat generated by the equipment, which reduces the effect or increases the production loss.

8) After the second step of stirring is completed, turn on the frequency conversion regulator, set a lower speed, 10 revolutions per minute (rpm), and finally add 2 parts of saffron oil, 2 parts of storax oil, and 1.5 parts of agarwood oil from the upper feeding port. 2 parts of sandalwood oil, 2 parts of benzoin oil, 2 parts of frankincense oil, 5 parts of rose oil, 15 parts of ethanol menthol solution prepared in advance, or 1-5 parts of jasmine oil, 1-5 parts of rose oil 5 parts, 1-5 parts of linalool thyme oil, 1-5 parts of Roman chamomile oil, 1-5 parts of lavender oil, 1-5 parts of claret oil, etc. All the raw materials are those with good liquid fluidity. They are also fat-soluble, and there is no need to adjust the speed. The stirring time is 30 minutes. After the stirring is completed, let it stand for 60 minutes and take a sample. The finished product should be bright brown or dark brown liquid liquid. , no delamination after standing.

9) The filling method is the same as in Example 1.

10) Filling is a brown glass bottle with glass beads for smearing, or a brown glass bottle for spraying medication, or a dual-purpose frosted bottle for nasal suction and rolling ball massage, or a single-use package in a frosted transparent BFS package. Packed for use.

11) The present invention has a total of 7 fragrance types preset in the original medicine fragrance type (without adding flavoring agent), rose fragrance type, jasmine fragrance type, agarwood thyme fragrance type, chamomile fragrance type, clary perilla fragrance type, and lavender fragrance type , other fragrance types are adjusted and added according to the safety announcement of the administrative approval of raw materials.

12) The present invention is in the form of health products for external use (health care products). According to the 2022 administrative examination and approval announcement of food-grade raw materials, the proportion of prescriptions is adjusted. The ingredients that can be added from the same source of medicine and food account for more than 76.8%, and the skin feeling regulator accounts for 16.3%. The safety ingredients are more than 93%, and it is implemented with emphasis on safety. It is aimed at a large number of consumers; it can be combined with specific acupuncture points of traditional Chinese medicine and massage balls, or smeared in physical therapy, which can relieve mechanical fatigue such as brain fatigue and driving fatigue. Headache, muscle pain and other muscle strain, or the health care effect of relieving symptoms of motion sickness, seasickness, vomiting and nausea.

Example 3:

1) Take Angelica, Angelica dahurica, Zanthoxylum bungeanum, Saffron, Atractylodes macrocephala, Rhizoma Chuanxiong, Safflower, Woody, Rhizoma Cyperi, Atractylodes atractylodes, Magnolia officinalis, Styrax, Agarwood, Sandalwood, Benzoin, through the supercritical _CO2 extraction process, the composition ratio, The content is calculated according to the weight of the extract after extraction.

2) The extraction kettle and the desorption kettle reach the specified temperature (160°C), and the pressure reaches the set value (30MPa); the rest of the extraction process is the same as that of Example 1.

3) Take ginseng, patchouli, nutmeg, mint leaves, whole mint plants, ginger, perilla leaves, tangerine peel, cloves, cinnamon, cumin, star anise, rhodiola rosea, salvia, ginkgo leaves, camphor bark, Camphor tree leaves, frankincense, magnolia flower, eucalyptus leaves, calamus, rose, thyme, Roman chamomile, and clove basil are extracted by steam distillation. The proportion and content of ingredients are calculated according to the weight of the extracted extract.

4) Heating and pressurizing with steam (1400 Pa), boiling (120° C.) and vaporizing to form an oil-water mixture, and the rest of the extraction process is the same as in Example 1.

5) Vitamin E (tocopheryl acetate) and jasmine oil/essential oil are used as stabilizers, additives, and flavoring (correcting) agents; menthol and 95% ethanol are used as skin feel regulators (cooling) It is an externally purchased raw material; and configure ethanol menthol solution, dissolve menthol in a ratio of 2:1 with ethanol for later use, that is, 10 parts of ethanol dissolve 5 parts of menthol, menthol is in a crystal form, and menthol can be directly and completely dissolved in vegetable oil. The purpose of configuring the ethanol menthol solution in advance is to reduce the stirring time and minimize the volatilization of volatile oil.

6) Firstly, it is distinguished according to the liquid fluidity of the extracted volatile oil, and the raw materials with better liquid fluidity are first added to the closed upper and lower conical normal temperature stirring tank, and the anchor type or frame type stirring head is used to avoid stirring heat and reduce stirring contact The raw materials that can be added for the first time are: 5 parts of Atractylodes macrocephala oil, 5 parts of Chuanxiong oil, 1 part of safflower oil, 4 parts of woody oil, 1.5 parts of Cyperus oil, 2 parts of Zanthoxylum bungeanum oil, 5 parts of rhodiola oil, ginseng oil 3 parts, 2 parts of camphor bark oil, 15 parts of camphor leaf oil, 10 parts of eucalyptus (tree) oil, 10 parts of patchouli oil, 2 parts of nutmeg oil, 5 parts of salvia oil, 5 parts of peppermint oil, 5 parts of peppermint oil 5 parts of ginger oil, 1 part of perilla leaf oil, 3 parts of magnolia flower oil, 5 parts of calamus oil, 5 parts of ginkgo leaf oil, 5 parts of tangerine peel oil, 10 parts of clove bud oil, 2 parts of clove leaf oil, cinnamon 1 part oil, 1 part cumin oil, 5 parts star anise oil, 8 parts clove basil oil, 5 parts thyme oil (thyme oil), 5 parts linalool thyme oil.

7) Put the closed upper and lower conical stirring tank at room temperature, turn on the frequency conversion regulator, set the lower speed, 10 revolutions per minute (rpm) to ensure that the previously added oil liquid is in a stirring state, and then add the liquid flow from the upper feed port Extract volatile oil with poor performance to avoid sticky loss of raw materials; the raw materials added in the second step are: 3 parts of atractylodes oil, 5 parts of magnolia oil, 5 parts of angelica oil, 1 part of angelica oil, and 1 part of vitamin E oil; increase the viscous oiliness After raw materials, set the stirring speed to 15-25 revolutions per minute (rpm), and the stirring time to 45-60 minutes. Since the raw materials are all fat-soluble liquids, they have good solubility and no precipitation or impurities; ensure that the stirring process It does not cause heat volatilization due to the heat generated by the equipment, which reduces the effect or increases the production loss.

8) After the second step of stirring is completed, turn on the frequency conversion regulator, set a lower speed, 10 revolutions per minute (rpm), and finally add 1 part of saffron oil, 2 parts of storax oil, and 1.5 parts of agarwood oil from the upper feeding port. 2 parts of sandalwood oil, 3 parts of benzoin oil, 2 parts of frankincense oil, 2 parts of rose oil, 15 parts of ethanol menthol solution prepared in advance, or 1-5 parts of jasmine oil, 1-5 parts of rose oil 1-5 parts of thyme oil, 1-5 parts of linalool thyme oil, 1-5 parts of Roman chamomile oil, 1-5 parts of lavender oil, 1-5 parts of claret oil, etc. All the raw materials belong to the raw materials with good liquid fluidity. They are also fat-soluble, and there is no need to adjust the speed. The stirring time is 30 minutes. No delamination after standing.

9) The filling method is the same as in Example 1.

10) Filling in a brown glass bottle with glass bead smear bottle (including a large-capacity roll-on smear bottle), or a brown glass bottle spray-type medication bottle, or a nasal suction-roll-on massage dual-purpose frosted bottle, or frosted transparent BFS single-use packaging is used in single-dose packaging.

The present invention does not preset fragrance types, and can add fragrance types upon submission of raw materials approved by the administrative examination and approval, which are all finished fragrance types; the somatosensory regulator or cooling agent of the present invention can be adjusted in multiples and parts as a form of enhanced cooling sensation.

The present invention is in the form of aromatherapy cosmetics (aromatherapy daily chemical products) or massage plant essential oils. According to the administrative approval announcement in 2022, raw materials can be added to adjust the prescription ratio; cooperate with specific acupuncture points of traditional Chinese medicine and massage balls, and apply them in aromatherapy or physical therapy. It can relieve mechanical fatigue such as brain fatigue and driving fatigue, muscle strain such as headache and muscle pain, or relieve the health effects of motion sickness, seasickness, vomiting and nausea.

Use the product of Example 1 of the present invention to carry out animal experiments:

1. Safety test:

1) Multiple skin irritation tests, two groups of test rabbits, four in each group, the test dose is 3 times and 5 times the daily recommended dosage;

2) Test preparation, the test standard rabbits were raised for three days after purchase, and the skin (shaved) 2*3cm was used as the test area. Considering the safety of the follow-up healthy volunteer subjects, the control method was not used, but expanded Sample size, select two groups as the test;

3) Routine use 3 times a day, that is, administer once every 6 hours, and apply the medicine evenly with a cotton swab; 3 times the dose is administered every two hours, six times a day; 5 times the dose is administered every 1 hour One time, 12 times a day; use a cotton swab dipped in pure water to clean the skin preparation area before administration again.

Table 1: The test standards refer to the "Guiding Principles for Skin Irritation Tests" issued by the State Food and Drug Administration to formulate the scoring standards.

5) Test results

Table 2: Safety experiment results

The safety test results show that in multiple skin irritation tests, the safety of conventional 3-fold dosage administration test is 97.5%, the safety of conventional 5-fold dosage administration is 92.5%, and the average safety of two multiple skin irritation tests is 95%. %, it can be relatively proved that this product has good safety, almost no irritation to non-sensitive skin; some mild erythema (barely visible) most of them disappeared after the second day, and no edema reaction occurred in any case.

2. Headache effectiveness animal test

1) Test name: Nitroglycerin experimental migraine model (Model of injecting nitroglycerin)

2) Test method 6 healthy rats, male or female, weighing 250-300 g. The model was established by subcutaneous injection of nitroglycerin at a dose of 10 mg/kg body weight. After modeling for about 30 minutes, the animal appeared red ears, frequent forelimb head scratching, increased cage climbing times, and restlessness. This phenomenon lasted for about 5 hours, and then appeared curled up and decreased activity. From the time of modeling, every 1 hour was regarded as a time period, and the number of scratching and climbing cages of the rats in each time period after modeling was observed by using the method of segmental counting of duration.

3) Model characteristics and introduction Nitroglycerin produces NO in the body, and NO causes aseptic inflammation through a strong expansion of cerebral blood vessels; on the other hand, NO has neurotoxic effects, which can stimulate trigeminal nerve-vascular reflex and induce experimental migraine . This pain stimulus activates glutamate-NMDA receptors or other receptors, further activates neuron second messengers, such as Ca2 ⁺ , etc., and induces an abnormal increase in the expression of c-fos gene in the central nervous system. Clinical studies have found that when patients with angina pectoris receive 0.3-0.4 mg of nitroglycerin, more than 50% of patients may experience migraine-like headaches. Continuous intravenous injection of nitroglycerin can cause dose-dependent recurrent headache in healthy people, but no pain in any other parts of the body. Therefore, nitroglycerin may act as a trigger for experimental migraine. The symptoms and pathological changes of this model are similar to those of human migraine attacks, and the pathological and biochemical data are stable. Therefore, this modeling method is easy to obtain, economical, simple, good similarity and applicability. Strong and other characteristics. This model supports the vascular theory.

4) Test standard:

The occurrence time of head scratching was marked by the number of rats scratching their head and climbing the cage more than 5 times continuously, and the symptom incidence rate per hour was taken as the symptom incidence rate per hour after continuous observation for 2 hours; Signs of burnout and fatigue appear. Dosing once an hour, smear evenly with cotton swabs, observe the changes in the mice, observe the four times of dosing and the symptom elimination rate, as the reference value of the total effective rate.

5) Experimental results:

Table 3: Results of animal tests on headache effectiveness

The experimental results show that the symptoms basically disappeared from the fourth administration to about the fifth hour, the symptom elimination rate of the experimental mice was about 92.9%, and the total effective rate was about 79.3%. Symptoms basically disappeared from the third administration about the fourth hour, and the symptom elimination rate of the test mice was about 92.9%, and the total effective rate was about 89.1%; The effective rate is about 84.2%, which is equivalent to that of single-component nonsteroidal anti-inflammatory drugs (NSAIDs) in similar experimental literature.

3. Vertigo effectiveness animal experiments

1) Modeling materials Animals: 3 Wistar rats, male, weighing 150-180 g; drug: kaolin biscuits (mixed with kaolin and gum arabic at a weight ratio of 50:1 and appropriate amount of distilled water, the shape is the same as that of the feed ); equipment: rotating stimulator (mouse wheel fatigue instrument and acrylic box modification).

2) Modeling method A rotating stimulator is used to make an animal motion sickness inducing device to generate rotating stimulation. During the experiment, the rats were put into the plexiglass (acrylic) cage of the motion sickness inducing device without restraint, rotated clockwise around the horizontal axis, accelerated at an angular acceleration of 16°/s2, and the maximum speed reached 120°/s, and then rotated at 48°/s °/s2 decelerates to 0°/s, so that the rotation stimulation acceleration and deceleration is alternately carried out for 1h. The amount of soil eaten by the rats for 3 days was then recorded.

3) Modeling principle Abnormal motion stimulation causes motion sickness in animals.

4) Changes after modeling General state: Before the experiment, the rats were sensitive and active, and their fur was smooth. After 1 hour of rotating stimulation, with the prolongation of the stimulation time, the performance is slow, the activity is obviously reduced, the reaction is slow, the fur of the whole body is erect and fluffy, showing a morbid state, and the frequency of urination increases. 1h after the end of the stimulation is still sluggish.

Administer with cotton swabs on both sides of the head and nose, and spread evenly;

Experimental results:

Table 4: Results of animal experiments on vertigo effectiveness

The experimental results show that the three groups of tests are all 100% effective, the average effective rate on the first day is 30.2%, the average effective rate on the second day is 34.3%, the average effective rate on the third day is 33.7%, and the average effective rate on the third day is 32.7% .

4. Experiments on healthy volunteers

It has been proven safe and effective through laboratory tests. Avoid laboratory participants, publicize the safety results of multiple skin irritation tests, and search internally for employees or family members with a history of headaches and dizziness without disclosing other test results.

Fill 3ml brown glass roll-on smear bottles and distribute them to healthy volunteers, and tell them to use it when headache and dizziness attack. It can be applied to the temple or both sides of the nose (Yingxiang point). When the attack occurs, it can be applied every 15 minutes. One time, the total observation time is 45 minutes. If it is more than 45 minutes and it is ineffective, you can take the medicine yourself, and it will be summarized in the office statistics record.

evaluation standard:

1) Pain and dizziness are alleviated or symptoms relieved within 15 minutes, and the effect is obvious;

2) Pain and dizziness are relieved or symptoms relieved within 30 minutes, effective;

3) Pain and dizziness for more than 45 minutes, no relief or symptom relief, invalid;

Experimental results:

Table 5: Test results of healthy volunteers

After testing with six healthy volunteers, 83.3% of the people reported that it was effective; only one healthy volunteer reported that it had a certain effect after smearing it three times, the symptoms were relieved, and the body felt better, but the effect was not obvious.

The above description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the present invention will not be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (5)

1. a kind of natural plant extracts volatile oil, is characterized in that, by weight, described volatile oil comprises following component: 5-10 parts of Atractylodes atractylodes oil, 1-5 parts of Atractylodes atractylodes oil, 1-10 parts of magnolia oil, 5-10 parts of Chuanxiong oil, 1-3 parts of safflower oil, 1-3 parts of saffron oil, 5-10 parts of angelica oil , 1-5 parts of Angelica oil, 1-5 parts of Suhe sesame oil, 1-10 parts of woody oil, 1-10 parts of Cyperus oil, 1-5 parts of agarwood oil, 1-10 parts of sandalwood oil, 1-10 parts of Zanthoxylum bungeanum oil 2-10 parts of benzoin oil, 5-10 parts of rhodiola oil, 1-5 parts of ginseng oil, 1-5 parts of camphor bark oil, 10-15 parts of camphor leaf oil, 5-15 parts of eucalyptus oil, patchouli 5-10 parts of sesame oil, 1-5 parts of nutmeg oil, 5-10 parts of salvia oil, 1-10 parts of frankincense oil, 5-10 parts of peppermint oil, 5-10 parts of peppermint oil, 5-10 parts of ginger oil , 1-5 parts of perilla leaf oil, 1-5 parts of magnolia flower oil, 1-5 parts of calamus oil, 5-10 parts of ginkgo leaf oil, 1-5 parts of tangerine peel oil, 1-5 parts of rose oil, clove buds 5-15 parts of oil, 1-5 parts of clove leaf oil, 1-5 parts of cinnamon oil, 1-3 parts of cumin oil, 5-10 parts of star anise oil, 5-15 parts of clove basil oil, 5-10 parts of menthol 10-30 parts of ethanol, 5-10 parts of thyme oil, 1-5 parts of linalool thyme oil, and 1 part of vitamin E oil. 2. a kind of natural plant extraction volatile oil according to claim 1 is characterized in that, in parts by weight, said volatile oil comprises flavoring agent 1-5 part; The flavoring agent is any one of linalool thyme oil, Roman chamomile oil, jasmine essential oil, claret oil, and lavender oil. 3. a kind of natural plant extraction volatile oil according to claim 1 is characterized in that, in parts by weight, the volatile oil comprises the following components: 10 parts of Atractylodes atractylodes oil, 5 parts of Atractylodes atractylodes oil, 10 parts of magnolia bark oil, 10 parts of Chuanxiong oil, 1 part of safflower oil, 1 part of saffron oil, 10 parts of angelica oil, 5 parts of angelica oil, 5 parts of storax oil, and woody oil 10 parts, cyperus oil 10 parts, agarwood oil 2 parts, sandalwood oil 10 parts, pepper oil 10 parts, benzoin oil 10 parts, rhodiola oil 10 parts, ginseng oil 3 parts, camphor tree bark oil 5 parts, camphor tree leaf oil 10 parts, eucalyptus oil 10 parts, patchouli oil 10 parts, nutmeg oil 5 parts, salvia miltiorrhiza oil 10 parts, frankincense oil 10 parts, peppermint oil 5 parts, peppermint oil 10 parts, ginger oil 10 parts, perilla leaves 1 part of magnolia oil, 5 parts of magnolia flower oil, 5 parts of calamus oil, 10 parts of ginkgo leaf oil, 5 parts of tangerine peel oil, 1 part of rose oil, 10 parts of clove bud oil, 2 parts of clove leaf oil, 1 part of cinnamon oil, 1 part fennel oil, 5 parts star anise oil, 10 parts clove basil oil, 5 parts menthol, 10 parts ethanol, 5 parts thyme oil, 3 parts linalool thyme oil, 1 part vitamin E oil. 4. the preparation method of a kind of natural plant extraction volatile oil described in claim 1 is characterized in that, comprises the following steps: 1) Angelica sinensis, Angelica dahurica, Zanthoxylum bungeanum, Saffron, Atractylodes macrocephala, Chuanxiong, safflower, Cyperus cyperi, Atractylodes atractylodis, Magnolia officinalis, Styrax, Agarwood, sandalwood, and benzoin in the formula amount are extracted by supercritical _CO2 : Wash and pulverize the raw materials respectively, put them into the supercritical extraction kettle, cool the storage tank, and heat the extraction kettle and the analysis kettle at the same time to a temperature of 60-160°C, open the _CO2 cylinder to supply air, and turn on the high-pressure pump Pressurize the extraction kettle and the analysis kettle, and when the pressure reaches 5.0-30MPa, start circular extraction; adjust the flow rate, keep constant temperature and pressure at 60°C/5.0MPa, extract for 2 hours, extract the volatile oil and collect it in a packaging container for later use; 2) Ginseng, patchouli, nutmeg, mint, ginger, perilla leaf, tangerine peel, clove leaf, clove flower bud, cinnamon, cumin, star anise, rhodiola rosea, salvia miltiorrhiza, ginkgo leaf, camphor bark , camphor leaves, frankincense, magnolia flowers, eucalyptus leaves, calamus, roses, thyme, Roman chamomile, clove basil using steam distillation extraction process: The raw materials are cleaned and crushed separately, placed in the distillation tank, injected with clean water, heated and pressurized by steam, 700-1400Pa, 100-120℃ boiling and vaporized to form oil-water mixture steam, and the mixture of essential oil and water is obtained through the condenser, essential oil Float on water, separate the oil from water, take the above essential oil to get volatile oil, put it into an aluminum bottle, seal it and store it in a cool place for later use; 3) Vitamin E oil, jasmine essential oil, menthol, and 95% ethanol are used as additives; Configure ethanol menthol solution: dissolve the ethanol and menthol in a weight ratio of 2:1 to obtain an ethanol menthol solution for subsequent use; 4) According to the liquid fluidity of the extracted volatile oil, add the volatile oil with better liquid fluidity to the closed upper and lower conical normal temperature stirring tank, and use the anchor type or frame type stirring head to avoid stirring heat and reduce the stirring contact surface; The volatile oils with better fluidity of the liquid are: clove bud oil, clove leaf oil, pepper oil, Atractylodes macrocephala oil, Chuanxiong oil, safflower oil, woody oil, Cyperus oil, ginseng oil, patchouli oil, nutmeg oil, Peppermint Oil, Peppermint Oil, Ginger Oil, Perilla Leaf Oil, Tangerine Peel Oil, Cinnamon Oil, Cumin Oil, Star Anise Oil, Salvia Oil, Ginkgo Biloba Oil, Camphor Bark Oil, Camphor Leaf Oil, Magnolia Flower Oil, Eucalyptus oil, calamus oil, clove basil oil, rhodiola oil, thyme oil, agarwood thyme oil; 5) Put the closed upper and lower conical mixing tank at room temperature, turn on the frequency conversion regulator, set the speed at 10rpm to ensure that the previously added oil-filled liquid is in a stirring state, and then add volatile oil with poor liquid fluidity from the upper feed port to avoid sticking of raw materials. viscous loss; The volatile oils with poor fluidity of the liquid are: angelica oil, angelica oil, atractylodes oil, magnolia oil, vitamin E oil; after adding viscous oily raw materials, the stirring speed is set to 15-25 revolutions per minute (rpm), Stirring time is set at 45-60 minutes, since the volatile oils are all fat-soluble liquids, with good solubility and no precipitation and impurities; ensure that the heat generated by the equipment during the stirring process will not cause heat volatilization, resulting in reduced effects or increased production losses; 6) After stirring, turn on the frequency conversion regulator, set a lower speed, 10 revolutions per minute (rpm), add storax oil, agarwood oil, sandalwood oil, benzoin oil, saffron oil, frankincense oil, For the ethanol menthol solution, add the corresponding flavoring agent according to the desired fragrance type. Since the last added raw materials are all liquid-fluid raw materials, they are also fat-soluble, so there is no need to adjust the speed. The stirring time is 30 minutes. Stand still for 60 minutes, take a sample, the finished product should be bright brown, dark brown fluid liquid, no stratification after standing; 7) From the closed upper and lower conical stirring tank at normal temperature, it is transferred to the automatic filling equipment or the blowing-filling-sealing machine through the pipeline, and it needs to stand for 30 minutes before filling, and the filling speed and Heat sealing speed, because the fat-soluble liquid itself has the physical characteristics of pipeline adhesion, there may be the problem of inaccurate dosage due to the loss of production pipeline equipment, the design filling should be 105%-115% of the marked filling volume, and air bubbles or production heat should be avoided as much as possible For the loss of the efficacy of extracting essential oils; Filling in brown glass bottle with glass bead roll-on smear bottle, brown glass bottle spray bottle, nasal suction-ball massage dual-purpose frosted bottle, frosted transparent BFS single-time packaging, any one of the above Packed for use. 5. the application of a kind of natural plant extraction volatile oil described in claim 1 in the preparation relief dizziness, headache medicine.