CN116617328A - Traditional Chinese medicine composition for treating coronary heart disease stable angina pectoris phlegm-blood stasis syndrome - Google Patents

Abstract

The application discloses a traditional Chinese medicine composition for treating coronary heart disease stability angina pectoris phlegm stasis syndrome, which is prepared from the following medicinal materials in parts by weight: 1-8 parts of snakegourd fruit, 1-4 parts of allium macrostemon, 1-4 parts of fructus aurantii, 1-3 parts of cassia twig, 1-3 parts of poria cocos, 1-3 parts of peach kernel, 1-3 parts of moutan bark and 1-3 parts of red paeony root. The traditional Chinese medicine is named as trichosanthes, allium macrostemon and cassia twig decoction, is prepared from traditional Chinese medicine classical formulas of 'immature bitter orange, allium macrostemon and cassia twig and poria cocos pill', is strict in formula compatibility, plays roles of resolving phlegm, releasing arthralgia, removing stasis and dredging collaterals together, has obvious treatment effect on coronary heart disease stability angina pectoris phlegm stasis syndrome, has small side effect and is worthy of clinical popularization.

Description

Traditional Chinese medicine composition for treating stable angina pectoris with coronary heart disease

technical field

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating coronary heart disease with stable angina pectoris and syndrome of intertwined phlegm and blood stasis.

Background technique

Coronary atherosclerotic heart disease (coronary heart disease for short) refers to a heart disease caused by myocardial ischemia, hypoxia or necrosis due to narrowing or occlusion of the lumen due to coronary atherosclerosis. At present, coronary heart disease is clinically divided into chronic myocardial ischemia syndrome and acute coronary syndrome. The former is also called stable coronary heart disease, and its most representative disease is stable angina pectoris.

According to the data released by the International Cooperative Research on Global Burden of Disease in 2017, coronary heart disease is the number one cause of death in the world. Standardized drug treatment has significantly improved the quality of life and long-term prognosis of patients. However, there are many risk factors for coronary heart disease, the pathophysiological process is complex, and the target of Western medicine is single, so it is difficult to intervene in all aspects of the disease, and some patients Intolerable side effects of drug therapy.

Coronary heart disease belongs to the category of "chest pain and heart pain" in traditional Chinese medicine, with "Yang Wei Yin string" as the basic pathogenesis, and it is a syndrome of deficiency in origin and excess in excess. Among them, deficiency in origin involves qi deficiency, blood deficiency, yin deficiency and yang deficiency; Reality includes cold coagulation, qi stagnation, blood stasis, phlegm turbidity. According to clinical investigation data, the syndrome of mixed phlegm and blood stasis has become one of the main clinical syndromes of stable angina pectoris. If there is no active intervention, it will greatly affect the quality of life and life expectancy of the people, and at the same time increase the economic burden of disease treatment.

Contents of the invention

The present invention intends to provide a traditional Chinese medicine composition for the treatment of stable angina pectoris with phlegm and blood stasis syndrome in coronary heart disease. The therapeutic effect of angina pectoris with mixed phlegm and blood stasis syndrome is remarkable, and the side effects are small.

The present invention provides following technical scheme:

The traditional Chinese medicine composition for treating stable angina pectoris of coronary heart disease with phlegm-stasis intertwining syndrome consists of the following medicinal materials in parts by weight: 1-8 parts of Trichosanthes mellifera, 1-4 parts of Scallops, 1-4 parts of Citrus aurantium, 1-4 parts of Guizhi 3 parts, 1-3 parts of poria cocos, 1-3 parts of peach kernel, 1-3 parts of Moutan bark, 1-3 parts of red peony root.

Further, the traditional Chinese medicine composition is composed of the following medicinal materials in parts by weight: 6 parts of fennel, 3 parts of scallion, 3 parts of citrus aurantium, 2 parts of cassia twig, 2 parts of poria cocos, 2 parts of peach kernel, 2 parts of Moutan bark, and red peony 2 servings.

Another object of the present invention is to provide the application of the traditional Chinese medicine composition in the preparation of medicines for treating stable angina pectoris of coronary heart disease with intertwined phlegm and blood stasis syndrome.

Another object of the present invention is to provide a medicine for treating stable angina pectoris with phlegm and blood stasis syndrome of coronary heart disease, using the traditional Chinese medicine composition as a raw material, including or not including pharmaceutically acceptable excipients, through conventional methods in the field Prepared into clinically acceptable preparations.

Further, the preparation is decoction or granule preparation.

Further, the preparation method of described decoction comprises the following steps:

Washing the raw materials of the traditional Chinese medicine, mixing with water, soaking, decocting, and filtering to obtain the first medicinal residue and the first decoction;

mixing the first medicinal residues with water, decocting, and filtering to obtain the second medicinal residues and the second decoction;

Mix the first decoction and the second decoction to obtain a decoction.

Further, when making the decoction, the mass ratio of the total mass of the traditional Chinese medicine raw materials to water is 1:10, and the soaking time is 30-60 minutes; 30-60 minutes; the mass ratio of the first medicinal residues to water is 1:5.

Gualou: Sweet in taste, slightly bitter, cold in nature, returns to lung, stomach and large intestine meridian. "Compendium of Materia Medica": "The main chest pain, Yueze people's face. The stems and leaves are used to treat heat and summer heat." "Changsha Yaojie": "It tastes sweet, slightly bitter, and slightly cold, and it starts with the Taiyin Lung Meridian. It clears the heart and moistens the lungs, washes away dirt and troubles, opens the numbness of the chest and diaphragm, washes away the stickiness of saliva, and cleanses turbidity best. Relieve regret". Pharmacological studies have shown that Trichosanthes can dilate coronary arteries and increase coronary blood flow. In larger doses, it can inhibit the heart, reduce myocardial contractility, and slow down heart rate. Trichosanthes can improve the hypoxia tolerance of animals. Trichosanthenic acid contained in Trichosanthes can inhibit platelet aggregation.

Xie Bai: pungent in taste, bitter, warm in nature, returns to the large intestine meridian. "Shen Nong's Materia Medica": "It tastes pungent and warm. It is mainly used for gold sores and sores. Light body, not hungry, and resistant to old age." "Changsha Yaojie": "Pungent in taste, warm in temperature, starts with Taiyin Lung and Hand Yangming Large Intestine Meridian. Opens chest obstruction and lowers adverse events, removes heavy and ascends depression, best relieves swelling and pain, and is good at stopping slippery diarrhea." Pharmacological studies have shown that the ethanol extract of Xiebai has the effects of anti-platelet aggregation, lowering blood lipid, anti-atherosclerosis, anti-oxidation and anti-inflammation.

Citrus aurantium: bitter in taste, pungent, sour, warm in nature, returns spleen, stomach meridian. "Leigong Pao Medicine Properties Solution": "It tastes bitter and sour, slightly cold in nature, non-toxic, enters the four meridians of lung, liver, stomach, and large intestine. It controls the highest qi in the lower chest, eliminates the phlegm in the heart, and vents the stagnation in the abdomen. Qi, remove the food in the middle of the stomach, reduce the accumulated accumulation in the abdomen for many years, relieve the disease of skin, hair, chest and diaphragm, dispel wind-qi, itching and numbness, unblock the large intestine, relieve cholera, treat intestinal wind, attack hemorrhoids, eliminate edema, and relieve wind pain .Remove the flesh and core, stir-fry the bran, good for a long time.” Pharmacological studies have shown that Fructus Aurantii has the functions of regulating gastrointestinal function and lowering blood fat.

Cinnamomum twig: acrid in the mouth, warm. "Compendium of Materia Medica": "Spicy, warm, non-toxic. Indications for upper Qi cough, stagnation, sore throat, vomiting and inhalation. Heartache, hypochondriac pain, hypochondriac pain, warming tendons, dredging veins, relieving restlessness and sweating, sharpening joints, Tonify the middle and replenish qi. Take it for a long time to improve the mind, lighten the body, and not grow old." "Changsha Yaojie": "It tastes sweet, pungent, fragrant, and warm in nature. It enters the liver of the foot Jueyin and the bladder meridian of the foot sun. It enters the liver to circulate the blood, and goes through the meridians to reach the stagnation of the camp. Regulate wood qi, elevate clear yang and relieve depression, reduce turbidity and yin, reverse and reverse, relax tendons and arteries, sharpen joint blockage, enter liver and gallbladder to dissipate and restrain, extremely relieve pain, dredge meridians and collaterals, relieve numbness and astringency, and even remove dampness and cold , can stop running dolphin, more peace of mind." Pharmacological studies have shown that cinnamon oil contained in cassia twigs can dilate blood vessels and improve blood circulation. In addition, cinnamon twigs also have anti-inflammatory effects, increase or decrease coronary blood flow, and improve heart function.

Poria cocos: sweet in taste, light in taste, flat in nature, returns to the heart, lung, spleen and kidney channels. "Shen Nong's Materia Medica": "Taste sweet, flat. Administers adverse qi in the chest and hypochondrium, anxiety, shock, palpitations, pain in the heart, cold and heat, irritability, cough, burning mouth and tongue, diuresis. Take it for a long time Replenish the soul, nourish the mind, not be hungry, and prolong life." "Changsha Yaojie": "Sweet in taste, calm in Qi, enters the stomach of foot Yangming, spleen of foot Taiyin, kidney of foot Shaoyin, and bladder of foot Taiyang. It can diure water and dry soil, relieve drink and eliminate phlegm, be good for throbbing and relieve depression. Fullness. Eliminates irritability under sweating, relieves dryness and thirst with drinking water, a magic product for phlegm and dysentery, a wonderful medicine for metrorrhagia and metrorrhagia. Effective in a thousand ways." Pharmacological studies have shown that Poria cocos mainly contains two compounds, triterpenoids and polysaccharides, which have diuretic, anti-inflammatory and increased myocardial contractility effects.

Peach kernel: bitter, sweet, flat in nature. "Shen Nong's Materia Medica": "Bitter, flat. Main blood stasis, blood stasis, lump in the abdomen, evil spirit. Kill small insects." "Lei Gong Pao Medicinal Properties Solution": "Bitter and sweet, flat in nature, non-toxic. It enters the liver and large intestine two meridians, and controls blood stasis and blood closure, lumps in the abdomen, ghost evil, blood dryness and stool knot, kills three insects, and relieves heartache." Pharmacological studies have shown that peach kernel water extract, amygdalin, and peach kernel fat can inhibit platelet aggregation.

Cortex Moutan: bitter, pungent, slightly cold in nature. "Shen Nong's Materia Medica": "Pungent, cold. Mainly cold and heat, stroke, convulsions, convulsions, convulsions, epilepsy, evil spirits, symptom removal, blood stasis and left in the stomach. Soothe the five internal organs, treat carbuncle wounds." "Changsha Yaojie": "bitter, pungent, slightly cold, enters the Liver Meridian of Foot Jueyin. Relieves wood stagnation and cools the wind, promotes blood stasis and relieves heat, expels pus and blood of carbuncle and gangrene, and transforms abdominal mass in viscera." Pharmacological studies have shown that Cortex Moutan has the functions of anti-myocardial ischemia, anti-atherosclerosis, regulating arrhythmia and lowering blood pressure.

Radix Paeoniae Rubra: Bitter in the mouth, slightly cold in nature. "Shen Nong's Materia Medica": "Bitter taste, flat. Mainly evil abdominal pain, eliminate blood numbness, break hard accumulation, cold and heat, hernia, relieve pain, facilitate urination, and replenish qi." "Book of Materia Medica": ""Book of Materia Medica" does not distinguish between red and white. Dongyuan said: the red one can benefit the urine and lower the qi, and the white one can relieve pain and disperse qi and blood. The common saying: white tonic and red diarrhea. "Compendium of Materia Medica" says: white peony root to benefit the spleen , can expel wood in the soil, red peony disperses evil, and can promote stagnation in blood. Postpartum qi and blood are deficient and cannot be more diarrhea. .And stir-fry with suitable wine after giving birth. If you are not stupid, don't use it for stability." Pharmacological studies have shown that Radix Paeoniae Rubra has anti-platelet aggregation, anti-thrombosis, anti-myocardial ischemia, improvement of microcirculation and anti-oxidation effects.

Beneficial effects of this side:

Zhishi Xiebai Guizhi Decoction and Guizhi Fuling Pills are both from the classic Chinese medicine book "Synopsis of the Golden Chamber". The former is a highly effective prescription for treating chest pain and heartache, while the latter is known as "Oriental Aspirin". Gualou Xiebai Guizhi Decoction is made from the above two prescriptions. Its medicines are: Gualou, Xiebai, Citrus aurantium, Guizhi, Poria, peach kernel, moutan bark and red peony root. Coronary heart disease belongs to the category of "chest obstruction and heart pain" in traditional Chinese medicine. Deficiency in origin and excess in superficiality are its main pathogenesis. Clinical syndromes mainly include qi deficiency, blood deficiency, yin deficiency, yang deficiency, cold coagulation, stagnation of qi, blood stasis and phlegm turbidity. Clinical studies have shown that with the prevalence of unhealthy lifestyles among residents, the syndrome of intertwined phlegm and blood stasis has become one of the main syndromes of stable angina. Gualou, clears phlegm and dissipates stagnation, opens the chest and unblocks numbness; peach kernel, promotes blood circulation and dredges collaterals, dispels blood stasis and relieves pain, and together with Gualou is a king drug. Scallions, clearing yang and dispelling stagnation, dispelling numbness and subduing adverse events, can dissolve phlegm turbidity accumulated in the upper energizer, relieve qi stagnation in the chest to widen the chest; moutan bark, red peony root, promote blood circulation and dredge collaterals, enhance the power of peach kernels to remove blood stasis; scallions, peonies Cortex and Radix Paeoniae Rubra are used in combination to enhance the effect of the monarch drug for clearing phlegm and removing blood stasis, and it is a ministerial drug. Phlegm turbidity and blood stasis are tangible evils that can easily block the body's Qi. Citrus aurantii, can lower the highest Qi in the chest, relieve the phlegm of the fullness in the heart, vent the stagnant Qi in the abdomen, remove the food in the stomach, reduce the accumulation of years in the abdomen, and thin the skin, hair, and chest. medicine. If the blood is unfavorable, then it is water, Poria cocos, diuresis, eliminating phlegm and expelling dampness, used together with blood-activating medicine, bringing into play the merit of treating blood and water together, is to make medicine. This prescription is derived from classics, and the compatibility of drugs is strict. The combination of various drugs has the effect of "eliminating phlegm and blood stasis, dredging collaterals and relieving pain".

Detailed ways

The technical solution will be described below in conjunction with specific implementation examples.

Example 1:

A traditional Chinese medicine composition for treating stable angina pectoris of coronary heart disease with phlegm and blood stasis syndrome. 2 parts, 2 parts of peach kernel, 2 parts of Moutan bark and 2 parts of red peony root, 5g each.

Wash the above-mentioned Chinese medicine raw materials, put them into a container and soak for 30 minutes, and then decoct them. After taking it, 1 month is a course of treatment, generally 1-3 courses of treatment.

Example 2:

A traditional Chinese medicine composition for treating stable angina pectoris of coronary heart disease with phlegm and blood stasis syndrome. 2 parts, 2 parts of peach kernel, 2 parts of Moutan bark and 2 parts of red peony root, 5g each.

Each traditional Chinese medicine adopts full-ingredient granules, and according to the above weight ratio, the obtained full-ingredient granules are fully mixed and then divided into 3 equal parts. 3 times a day, 1 serving each time, take with boiled water after meal, 1 month is 1 course of treatment, generally 1-3 courses of treatment.

case one

Zhang, male, 67 years old, body mass index 26.52kg/m ² . Chief complaint: intermittent chest pain for more than 6 years, aggravated for 1 week. The patient underwent coronary angiography in 2015 due to chest pain, which indicated: severe stenosis in the proximal and middle sections of the anterior descending artery, moderate stenosis in the proximal section of the first diagonal branch, moderate stenosis in the proximal section of the circumflex branch, and moderate stenosis in the proximal section of the right coronary artery. Two stents were implanted in the anterior descending artery, and medication was prescribed after the operation, and heart rate and blood lipids were controlled up to standard. In the past 1 week, the patient experienced precordial pain again during activities, accompanied by shortness of breath, which can be relieved by itself after rest. Body of the tongue is dark red, sublingual collaterals are tortuous, and the fur is white and moist. Deep pulse. He had a history of "type 2 diabetes and hypertension grade 3" in the past. The western medicine diagnosis is: coronary heart disease-stable angina pectoris-coronary stent implantation postoperative state, and the traditional Chinese medicine diagnosis is: chest obstruction and heart pain (syndrome of intertwined phlegm and blood stasis). The prescription consists of 6 parts of Gualou, 3 parts of Scallops, 3 parts of Citrus aurantii, 2 parts of Guizhi, 2 parts of Poria cocos, 2 parts of peach kernel, 2 parts of Moutan bark and 2 parts of red peony root, 5g each. Advise on the basis of standard western medicine treatment, take 7 pairs of above-mentioned prescriptions, during the period of taking the medicine, fasting fat, sweet, thick and greasy products. During follow-up consultation, the patient complained that the number of episodes of chest pain decreased, without dizziness, and continued to give the upper 14 doses.

case two

Xiong, female, 64 years old, body mass index 24.97kg/m ² . Chief complaint: Chest pain for 1 month. For more than a month, the patient has repeatedly experienced dull pain in the precordial area, which is related to activities, accompanied by dizziness, shortness of breath, and fatigue. %, because he refused to perform stent placement, he usually took aspirin enteric-coated tablets, atorvastatin calcium tablets, metoprolol succinate sustained-release tablets, isosorbide mononitrate sustained-release tablets and other drugs. The body of the tongue is dark red, the coating is white and greasy, and the pulse is deep and slow. The skin of the lower extremities is wrong. Western medicine diagnosis is: stable angina pectoris, and Chinese medicine diagnosis is: chest obstruction and heart pain (syndrome of mutual accumulation of phlegm and blood stasis). The prescription consists of 7 parts of Gualou, 3 parts of Scallops, 3 parts of Citrus aurantii, 2 parts of Guizhi, 2 parts of Poria cocos, 2 parts of peach kernel, 2 parts of Moutan bark and 2 parts of red peony root, 5g each. Advise on the basis of standardized Western medicine treatment, and give the top 14 pays, fasting fat, sweet and thick greasy products during the medication. During follow-up consultation, the patient complained that there was no obvious chest pain outbreak in recent days, advised to continue to take traditional Chinese medicine treatment, and gave 14 of the above prescriptions.

case three

Yu, male, 77 years old, body mass index 34.16kg/m ² . Chief complaint: intermittent chest pain for more than 9 years, recurring for 2 days. The patient began to experience intermittent chest pain in 2013, which was related to activities and gradually relieved after rest, which was not taken seriously. In 2017, due to sudden chest pain that persisted and did not relieve, he went to the hospital and was diagnosed with acute inferior wall myocardial infarction. Emergency coronary angiography showed that the middle segment of the right coronary artery was occluded, and the proximal segment of the anterior descending artery was moderately narrowed. One stent was placed in the occlusion treatment, and the medication was continued after the operation, but the blood lipid control was not up to standard. In the past 2 days, the patient experienced discomfort in the mid-section of the retrosternum again, which was related to activities and could be relieved after taking nitroglycerin. It was accompanied by palpitation, fatigue, nausea from time to time, loss of appetite, lack of appetite, excessive sleepiness, and two stools were okay. Dark lips, dark red tongue, sublingual ecchymosis, white and greasy fur. Slow pulse. The western medicine diagnosis is: old myocardial infarction-stable angina pectoris-coronary stent implantation postoperative state, and the traditional Chinese medicine diagnosis is: chest obstruction and heart pain (syndrome of intertwined phlegm and blood stasis). The prescription consists of 7 parts of Gualou, 3 parts of Allium, 3 parts of Citrus aurantium, 2 parts of Guizhi, 2 parts of Poria, 2 parts of peach kernel, 2 parts of Moutan bark and 2 parts of red peony. Advise on the basis of standardized Western medicine treatment, and give the top 14 pays, fasting fat, sweet and thick greasy products during the medication. During the follow-up consultation, the patient complained of chest pain after taking the medicine, the duration was shortened, the consumption of nitroglycerin was reduced, and the feeling of fatigue was relieved. At the next follow-up visit, the patient complained of occasional episodes of chest pain, which could be relieved by itself after rest, and felt that he was in good spirits. The body of the tongue is dark red, the fur is thin and white, ecchymosis can be seen under the tongue, and the pulse is deep and slow. Order to continue taking the top 14 payment.

Precautions while taking the medicine: fasting of fatty, sweet and greasy products, fasting of cold drinks, quitting smoking and drinking, avoid staying up late, insist on exercising, 3 to 5 times a week.

What is described above is only an embodiment of the present invention, and common knowledge such as specific technical solutions and/or characteristics known in the solutions will not be described here too much. It should be pointed out that for those skilled in the art, without departing from the technical solutions of the present invention, some modifications and improvements can also be made, which should also be regarded as the protection scope of the present invention, and these will not affect the implementation of the present invention effect and utility of the patent. The scope of protection required by this application shall be based on the content of the claims, and the specific implementation methods and other records in the specification may be used to interpret the content of the claims.

Claims (7)

1. The traditional Chinese medicine composition for treating the coronary heart disease stable angina pectoris phlegm stasis syndrome is characterized by comprising the following medicinal materials in parts by weight: 1-8 parts of snakegourd fruit, 1-4 parts of allium macrostemon, 1-4 parts of fructus aurantii, 1-3 parts of cassia twig, 1-3 parts of poria cocos, 1-3 parts of peach kernel, 1-3 parts of moutan bark and 1-3 parts of red paeony root.

2. The traditional Chinese medicine composition for treating coronary heart disease stability angina pectoris phlegm stasis syndrome according to claim 1, which is characterized by comprising the following medicinal materials in parts by weight: 6 parts of snakegourd fruit, 3 parts of allium macrostemon, 3 parts of fructus aurantii, 2 parts of cassia twig, 2 parts of poria cocos, 2 parts of peach kernel, 2 parts of tree peony bark and 2 parts of red paeony root.

3. The use of the Chinese medicinal composition according to claim 1 or 2 in the preparation of a medicament for treating coronary heart disease stability angina pectoris phlegm stasis syndrome.

4. A medicine for treating coronary heart disease stable angina pectoris phlegm stasis syndrome is prepared from the Chinese medicinal composition according to claim 1 or 2, including or not including pharmaceutically acceptable auxiliary materials, through conventional methods in the art.

5. The medicament of claim 4, wherein the formulation is a decoction or a granule formulation.

6. The medicine according to claim 5, wherein the preparation method of the decoction comprises the following steps:

cleaning the traditional Chinese medicine raw materials, mixing with water, soaking, decocting, and filtering to obtain first decoction dregs and first decoction;

mixing the first medicinal residue with water, decocting, and filtering to obtain second medicinal residue and second decoction;

and mixing the first decoction and the second decoction to obtain decoction.

7. The medicine according to claim 6, wherein the mass ratio of the total mass of the raw materials of the traditional Chinese medicine to the water is 1:10, the soaking time is 30-60 min; the decoction is carried out by boiling with strong fire and then decocting with slow fire for 30-60 min; the mass ratio of the first medicine residues to the water is 1:5.