CN116585219A - A kind of eye care composition for alleviating asthenopia and preparation method thereof - Google Patents

Abstract

The invention provides an eye care composition for relieving asthenopia and a preparation method thereof, and belongs to the field of eye care compositions. The eye care composition for relieving asthenopia and the preparation method thereof comprise the following steps: pretreatment, preparation of active hydrogels, preparation of eye care compositions. The eye care composition has small irritation to eyes and skin, has no toxic or side effect, and effectively avoids the irritation of components such as functional substances, preservatives and the like to eyes and skin and the discomfort of eyes or skin possibly occurring in long-term use; the effective components of the eye care composition are easy to absorb, and can effectively relieve visual fatigue; and further improves the long-term storage stability of the eye care composition.

Description

A kind of eye care composition for alleviating asthenopia and preparation method thereof

technical field

The invention relates to the field of eye care compositions, in particular to an eye care composition for relieving visual fatigue and a preparation method thereof.

Background technique

Asthenopia Syndrome is a state of continuous weakness of the eyes after long-term overload work. Its clinical manifestations mainly include eye soreness, eye swelling, dry eyes, tearing, and blurred vision. It belongs to the category of psychosomatic medicine. In recent years, due to changes in the social environment, the popularization of electronic products, the accelerated pace of work, and the increase in the number of people with refractive errors, there have been more and more cases of overloading the eyes, and the incidence of visual fatigue has increased year by year.

With the advancement of technology, there are more and more types of electronic products. Electronic products not only serve as entertainment tools, but also exist as indispensable tools for work, study and life. Therefore, people spend more and more time using electronic devices, so they need to bear excessive eye load, and then produce related symptoms of visual fatigue. At present, it is recognized that local health care methods can relieve visual fatigue and refractive errors. Most patients cannot get enough rest for their eyes due to work or study, and it is difficult to relieve related symptoms.

Therefore, the symptoms of visual fatigue are complex and changeable, and the severity of symptoms is closely related to personal personality, psychological state, living and working environment. At present, the treatment of asthenopia mainly includes correction of refractive error, correction of eye position, adjustment function training, and drug therapy. However, although surgical treatment, prism correction, functional training and other methods have good curative effects, they are limited in scope and cannot be applied to the vast majority of visual fatigue patients; and drug treatment not only has certain toxic and side effects, but may also cause drug dependence. While modern people are under tremendous work and life pressure, it is difficult to avoid overloading the eyes, and it is also difficult to effectively adjust the daily work and rest time, which also makes it difficult to effectively implement some effective preventive measures for visual fatigue in actual work and life.

For eye care, relieve visual fatigue, products such as eye care solution, artificial tears and eyewash are arranged in the prior art. Among them, artificial tears are physiological saline that simulates tears without other additives, but their ability to relieve eye care and visual fatigue is limited. Eyewash and eye care solutions are usually compounded with purified water or distilled water and functional substances, additives and other ingredients; by dripping into the eyelids or coating on the eyelids, the eye care function is realized, and then Relieve visual fatigue to a certain extent. However, the inventor has found through research that the functional substances, preservatives and other components added in the existing eye care composition have certain irritation to the eyes and skin, and long-term use may cause hyperemia and hair loss of the eyes and skin. Itching, redness and other side effects. At the same time, after the eye care composition is applied to the eyelids, the active ingredients are not easily absorbed by the skin, and the absorbability needs to be further improved. Moreover, after the existing eye care composition is opened, the stable storage time is relatively short, the active ingredients are prone to failure, and the long-term storage stability needs to be further improved.

Contents of the invention

In order to solve the technical problems existing in the prior art, the present invention provides an eye care composition for relieving visual fatigue and a preparation method thereof, which is less irritating to eyes and skin, has no toxic and side effects, and effectively avoids functional substances and preservatives The ingredients such as eye and skin irritation, and eye or skin discomfort that may occur after long-term use; the active ingredients of the eye care composition are easy to absorb, and can effectively relieve visual fatigue; further improve the long-term storage stability of the eye care composition.

For solving above technical problem, the technical scheme that the present invention takes is as follows:

A method for preparing an eye care composition for relieving visual fatigue, comprising the following steps: pretreatment, preparation of active hydrogel, and preparation of an eye care composition.

In the pretreatment, put sodium hyaluronate into 95-100 times the weight of deionized water, disperse evenly, cool down to 2-5°C, and keep it for 4-6h; adjust the pH value to 8-8.5, and keep the temperature Stir at 2-5°C for 20-30min; then put in methacrylic anhydride, and keep warm for 10-12h at a temperature of 2-5°C to obtain a pretreatment liquid; put the pretreatment liquid into 3-5 times the volume In dehydrated ethanol, until there is no precipitation, filter out the solid matter; after the solid matter is washed with 8-10 times the volume of dehydrated ethanol, it is put into 75-85 times the weight of deionized water, and after being stirred evenly, it is treated by dialysis , to obtain a pretreatment.

In the pretreatment, the weight ratio of sodium hyaluronate to methacrylic anhydride is 1:2.5-3.

In the pretreatment, the molecular weight cut-off during the dialysis treatment is 10-12KDa, and the dialysis treatment time is 20-24h.

To prepare the active hydrogel, put the active ingredient into deionized water and stir for 20-40 minutes; then put in the pretreated product, N-isopropylacrylamide, and continue stirring for 20-30 minutes; in a nitrogen atmosphere, 100- Under the condition of stirring at 200rpm, the temperature is raised to 30-35°C, ammonium persulfate is added, and the mixture is kept stirring for 1-3 hours to prepare the active hydrogel.

In the preparation of the active hydrogel, the weight ratio of the pretreatment, N-isopropylacrylamide, active ingredient, ammonium persulfate, and deionized water is 30-35:70-75:7-9:0.5- 0.6:1000-1200.

In the preparation of the active hydrogel, the active ingredient is composed of the following ingredients: Luo Han Guo extract, sweet potato leaf extract, and blueberry extract; preferably, the weight ratio of Luo Han Guo extract, sweet potato leaf extract, and blueberry extract is 12 -15:8-10:3-5.

Preferably, the specification of Luo Han Guo extract is 80-100 mesh, and the extraction ratio is 10-20:1;

The specification of sweet potato leaf extract is 80-100 mesh, and the extraction ratio is 10-20:1;

The specification of blueberry extract is 80-100 mesh, and the extraction ratio is 10-20:1.

To prepare the eye care composition, put disodium edetate, carbomer, hydrolyzed collagen, and glycerin into sterilized deionized water, and after dispersing evenly, continue to put in active hydrogel, 1, 2-pentanediol, glyceryl stearate, jojoba oil, L-serine, vitamin E, tocopheryl acetate and stearyl alcohol are uniformly mixed to prepare an eye care composition for relieving visual fatigue.

In the preparation of the eye care composition, deionized water, disodium edetate, carbomer, hydrolyzed collagen, glycerin, active hydrogel, 1,2-pentanediol, glyceryl stearate , jojoba oil, L-serine, vitamin E, tocopheryl acetate, stearyl alcohol in parts by weight ratio of 40-45:0.15-0.2:0.5-0.6:2-3:4-5:40-45: 6-7:2-3:0.8-1:1.5-2:0.15-0.2:0.05-0.06:0.8-1.

An eye care composition for relieving asthenopia, prepared by the aforementioned preparation method.

Compared with prior art, the beneficial effect of the present invention is:

(1) The preparation method of the eye care composition for relieving visual fatigue of the present invention, the eye care composition for relieving visual fatigue, pretreats sodium hyaluronate by using methacrylic anhydride; and uses the pretreatment, N-isopropylacrylamide and active ingredients are used in the step of preparing active hydrogel; the active hydrogel is combined with other specific raw materials to prepare an eye care composition for relieving visual fatigue and irritation to eyes and skin It has low toxicity, no toxic and side effects, and can effectively avoid eye and skin irritation by functional substances, preservatives and other ingredients, as well as eye or skin discomfort that may occur after long-term use; the active ingredients of the eye care composition are easy to absorb, and can effectively relieve vision loss. fatigue; and further improve long-term storage stability of eye care compositions.

(2) The eye care composition for relieving visual fatigue of the present invention, through the cosmetic sensitization test, the skin of the test animal has no erythema and eschar formation, no edema, the sensitization rate is 0%, no irritation to the skin, and is effective Avoid eye and skin irritation from functional substances, preservatives and other ingredients, as well as eye and skin discomfort that may occur after long-term use.

(3) The eye care composition for relieving visual fatigue of the present invention has obvious antibacterial effect on Staphylococcus aureus and Escherichia coli through in vitro antibacterial test, and has good antibacterial and antiseptic effects; it is specifically expressed as eye care composition After being diluted to 50%, it still has good antibacterial properties.

(4) According to tests, the eye care composition for relieving visual fatigue of the present invention can effectively relieve visual fatigue, and relieve eye tension, fuzziness, pain and fatigue caused by long-term use of electronic products The effect is good, the marked rate is 80-85%, and the effective rate is 15-20%.

(5) According to the test, the eye care composition for relieving visual fatigue of the present invention has no shape change, no delamination, precipitation, precipitation, etc. , good long-term storage stability.

Detailed ways

In order to have a clearer understanding of the technical features, purposes and effects of the present invention, specific implementations of the present invention are now described.

Example 1

A preparation method of an eye care composition for alleviating visual fatigue, specifically:

1. Pretreatment

Put sodium hyaluronate into 95 times the weight of deionized water, disperse evenly, cool down to 2°C, and keep it for 4 hours; use sodium bicarbonate-sodium carbonate buffer to adjust the pH value to 8, and keep the temperature at 2°C. Stir for 20 minutes; then put in methacrylic anhydride, heat preservation treatment at 2°C for 10 hours to obtain a pretreatment solution; put the pretreatment solution into 3 times the volume of absolute ethanol until no precipitation occurs, and filter out the solids After the solid matter is washed with 8 times the volume of absolute ethanol, it is dropped into 75 times the weight of deionized water, stirred for 30 minutes, transferred to a dialysis bag with a molecular weight cut-off of 10KDa, and carried out dialysis treatment with flowing deionized water for 20 hours , to obtain a pretreatment.

Wherein, the weight ratio of sodium hyaluronate to methacrylic anhydride is 1:2.5.

2. Preparation of active hydrogel

Put the active ingredient into deionized water and stir for 20 minutes; then put in the pretreated material and N-isopropylacrylamide and continue to stir for 20 minutes; in a nitrogen atmosphere, under the condition of 100rpm stirring, raise the temperature to 30°C, and put in ammonium persulfate , and kept stirring for 1 h to obtain an active hydrogel.

Wherein, the weight ratio of the pretreatment product, N-isopropylacrylamide, active ingredient, ammonium persulfate and deionized water is 30:70:7:0.5:1000.

The active ingredient is composed of the following components in parts by weight: 12 parts of Luo Han Guo extract, 8 parts of sweet potato leaf extract, and 3 parts of blueberry extract.

The specification of the Luo Han Guo extract is 80 mesh, and the extraction ratio is 10:1.

The specification of sweet potato leaf extract is 80 mesh, and the extraction ratio is 10:1.

The specification of blueberry extract is 80 mesh, and the extraction ratio is 10:1.

3. Preparation of eye care composition

Raise the temperature of deionized water to 85°C, keep it warm for 20 minutes, and naturally cool to room temperature, add disodium ethylenediamine tetraacetate, carbomer, hydrolyzed collagen, glycerin, and after dispersing evenly, continue to add active hydrogel, 1,2 - Pentylene glycol, glyceryl stearate, jojoba oil, L-serine, vitamin E, tocopheryl acetate, stearyl alcohol, mixed evenly to prepare an eye care composition for relieving visual fatigue.

Among them, deionized water, edetate disodium, carbomer, hydrolyzed collagen, glycerin, active hydrogel, 1,2-pentanediol, glyceryl stearate, jojoba oil, L-serine , vitamin E, tocopheryl acetate, and stearyl alcohol in parts by weight are 40:0.15:0.5:2:4:40:6:2:0.8:1.5:0.15:0.05:0.8.

Example 2

A preparation method of an eye care composition for alleviating visual fatigue, specifically:

1. Pretreatment

Put sodium hyaluronate into 97 times the weight of deionized water, disperse evenly, cool down to 3°C, keep the temperature for 5h; use sodium bicarbonate-sodium carbonate buffer to adjust the pH value to 8.2, keep the temperature at 3°C, Stir for 25 minutes; then put in methacrylic anhydride, heat preservation treatment at 3°C for 11 hours to obtain the pretreatment solution; put the pretreatment solution into 4 times the volume of absolute ethanol until no precipitation occurs, and filter out the solid After the solid matter is washed with 9 times the volume of absolute ethanol, it is dropped into 80 times the weight of deionized water, stirred for 40 minutes, transferred to a dialysis bag with a molecular weight cut-off of 11KDa, and carried out dialysis treatment with flowing deionized water for 22 hours , to obtain a pretreatment.

Wherein, the weight ratio of sodium hyaluronate to methacrylic anhydride is 1:2.7.

2. Preparation of active hydrogel

Put the active ingredient into deionized water and stir for 30 minutes; then put in the pretreated material and N-isopropylacrylamide and continue stirring for 25 minutes; in a nitrogen atmosphere, under the stirring condition of 150rpm, raise the temperature to 32°C, and put in ammonium persulfate , and kept stirring for 2 hours to obtain an active hydrogel.

Wherein, the weight ratio of the pretreatment product, N-isopropylacrylamide, active ingredient, ammonium persulfate and deionized water is 32:73:8:0.55:1100.

The active ingredient is composed of the following components in parts by weight: 13 parts of Luo Han Guo extract, 9 parts of sweet potato leaf extract, and 4 parts of blueberry extract.

The specification of the Luo Han Guo extract is 100 mesh, and the extraction ratio is 20:1.

The specification of sweet potato leaf extract is 100 mesh, and the extraction ratio is 20:1.

The specification of blueberry extract is 100 mesh, and the extraction ratio is 20:1.

3. Preparation of eye care composition

Raise the temperature of deionized water to 90°C, keep it warm for 25 minutes, and naturally cool it to room temperature. Add disodium edetate, carbomer, hydrolyzed collagen, and glycerin. - Pentylene glycol, glyceryl stearate, jojoba oil, L-serine, vitamin E, tocopheryl acetate, stearyl alcohol, mixed evenly to prepare an eye care composition for relieving visual fatigue.

Among them, deionized water, edetate disodium, carbomer, hydrolyzed collagen, glycerin, active hydrogel, 1,2-pentanediol, glyceryl stearate, jojoba oil, L-serine , vitamin E, tocopheryl acetate, and stearyl alcohol in parts by weight are 42:0.17:0.55:2.5:4.5:42:6.5:2.5:0.9:1.7:0.18:0.055:0.9.

Example 3

A preparation method of an eye care composition for alleviating visual fatigue, specifically:

1. Pretreatment

Put sodium hyaluronate into 100 times the weight of deionized water, disperse evenly, cool down to 5°C, keep it warm for 6h; use sodium bicarbonate-sodium carbonate buffer to adjust the pH value to 8.5, keep the temperature at 5°C, Stir for 30 minutes; then put in methacrylic anhydride, heat preservation treatment at 5°C for 12 hours to obtain the pretreatment solution; put the pretreatment solution into 5 times the volume of absolute ethanol until no precipitation occurs, and filter out the solid After the solid matter is washed with 10 times the volume of absolute ethanol, it is dropped into 85 times the weight of deionized water, stirred for 50 minutes, transferred to a dialysis bag with a molecular weight cut-off of 12KDa, and carried out dialysis treatment with flowing deionized water for 24 hours , to obtain a pretreatment.

Wherein, the weight ratio of sodium hyaluronate to methacrylic anhydride is 1:3.

2. Preparation of active hydrogel

Put the active ingredient into deionized water and stir for 40 minutes; then put in the pretreated material and N-isopropylacrylamide and continue stirring for 30 minutes; in a nitrogen atmosphere, under the condition of 200rpm stirring, raise the temperature to 35°C, and put in ammonium persulfate , and kept stirring for 3 hours to prepare an active hydrogel.

Wherein, the weight ratio of the pretreatment product, N-isopropylacrylamide, active ingredient, ammonium persulfate and deionized water is 35:75:9:0.6:1200.

The active ingredient consists of the following components in parts by weight: 15 parts of Luo Han Guo extract, 10 parts of sweet potato leaf extract, and 5 parts of blueberry extract.

The specification of the Luo Han Guo extract is 90 mesh, and the extraction ratio is 15:1.

The specification of sweet potato leaf extract is 90 mesh, and the extraction ratio is 15:1.

The specification of blueberry extract is 90 mesh, and the extraction ratio is 15:1.

3. Preparation of eye care composition

Raise the temperature of deionized water to 90°C, keep it warm for 25 minutes, and naturally cool it to room temperature. Add disodium edetate, carbomer, hydrolyzed collagen, and glycerin. - Pentylene glycol, glyceryl stearate, jojoba oil, L-serine, vitamin E, tocopheryl acetate, stearyl alcohol, mixed evenly to prepare an eye care composition for relieving visual fatigue.

Among them, deionized water, edetate disodium, carbomer, hydrolyzed collagen, glycerin, active hydrogel, 1,2-pentanediol, glyceryl stearate, jojoba oil, L-serine , vitamin E, tocopheryl acetate, and stearyl alcohol in parts by weight are 45:0.2:0.6:3:5:45:7:3:1:2:0.2:0.06:1.

Comparative example 1

Adopt the technical scheme of embodiment 2, its difference is: omit preparation active hydrogel step, and omit the addition of active hydrogel in the preparation eye care composition step of active hydrogel, and pretreatment thing, active ingredient , directly used in the step of preparing the eye care composition. In the step of preparing the eye care composition, deionized water, disodium edetate, carbomer, hydrolyzed collagen, glycerin, pretreatment, active ingredient, 1,2-pentanediol, glyceryl stearin Ester, jojoba oil, L-serine, vitamin E, tocopheryl acetate, stearyl alcohol ratio in parts by weight are 71.5:0.17:0.55:2.5:4.5:3:5:6.5:2.5:0.9:1.7: 0.18:0.055:0.9.

The skin irritation of the eye care composition for relieving visual fatigue of Examples 1-3 and Comparative Example 1 was tested, and the relevant test requirements refer to the relevant provisions of the national standard GB/T21608-2008 "Chemical Skin Sensitization Test Method" , the specific test method is as follows:

Select 100 albino guinea pigs of similar age and body weight of 280-300 g, including 50 male albino guinea pigs and 50 female albino guinea pigs. The albino guinea pigs were randomly divided into 5 groups, 20 in each group, and the control group was divided into male albino guinea pigs and female albino guinea pigs.

The hair on both sides of the back of each albino guinea pig in groups 1-5 was removed, and the area of hair removal on one side was 3cm*3cm. Among them, groups 1-4 correspond to the application of the eye care composition for relieving visual fatigue of Examples 1-3 and Comparative Example 1, and group 5 is a blank control group, corresponding to the application of deionized water.

Take 0.4mL of the eye care composition and physiological saline for relieving visual fatigue of Examples 1-3 and Comparative Example 1, and apply them to the left hair removal area of the albino guinea pigs corresponding to each group. The surface of the removed area was covered with two layers of gauze and a layer of cellophane, and then sealed and fixed with non-irritating tape for 6 hours; on the 7th and 14th day, the above operation was repeated once. At the same time, on the 14th day, take 0.5mL of the eye care composition for relieving visual fatigue and physiological saline of Example 1-3 and Comparative Example 1-2, and apply it to the depilatory area on the right side of the albino guinea pig corresponding to each group After the coating is completed, cover the surface of the hair removal area with two layers of gauze and a layer of cellophane, and then seal and fix it with non-irritating tape. At the 6h, 24h, and 48h, observe the skin allergic reaction and refer to GB /T21608-2008 in the relevant regulations for scoring. The specific test results are as follows:

It can be seen that the eye care composition for relieving visual fatigue of Examples 1-3 has no sensitization to animal skin, and the eye care composition of Comparative Example 1 has weak sensitization, showing barely visible slight erythema, The sensitization rate was 5%.

Further, the eye care composition for alleviating visual fatigue of Examples 1-3 and Comparative Example 1 was subjected to an in vitro antibacterial test, and the specific test methods were as follows:

The eye care compositions of Examples 1-3 and Comparative Example 1 were diluted to 50% respectively, and the undiluted eye care compositions and the eye care compositions diluted to 50% were used to carry out the antibacterial activity test in vitro The bacteria used in the test are Staphylococcus aureus and Escherichia coli; for the specific test method, refer to the relevant content in "Technical Specifications for Disinfection" - 2.1.7.3 Minimum Inhibitory Concentration Determination Test. The specific test results are as follows:

It can be seen that the eye care composition of Examples 1-3 has obvious antibacterial effect on Staphylococcus aureus, Escherichia coli, and has good antibacterial and antiseptic effects; it is specifically shown that the eye care composition is diluted to 50%. , still has good antibacterial properties.

Further, the eye care composition for relieving visual fatigue of Examples 1-3 and Comparative Example 1 was tested for relieving visual fatigue performance, and the specific test methods were as follows:

Select 80 volunteers aged 20-35 years old, with eyesight of 300-500 degrees, and use electronic products (such as computers, etc.) for no less than 7 hours a day. The number of male and female volunteers is 40. They were randomly divided into 4 groups, and each group was kept half male and half female. Groups 1-4 correspond to the application of the eye care compositions of Examples 1-3 and Comparative Example 1 for relieving visual fatigue. The application method is, after cleaning the face, remove the eye care composition of the size of mung bean grains and apply it evenly Apply to upper eyelid, lower eyelid and around the eyes. Apply twice a day, after continuous application for 20 days, investigate the application effect of the eye care composition, and count the corresponding number of people.

Among them, the judgment on the application effect includes the following three categories: markedly effective, effective, and ineffective.

The significant effect is that after using the electronic product for more than 2 hours, compared with before applying the eye care composition, the sense of tightness, fuzziness, pain and fatigue of the eyes are effectively relieved at the same time.

Effectively, after using the electronic product for more than 2 hours, compared with before applying the eye care composition, the eye tightness, blurring, pain and fatigue are relieved to a certain extent.

Ineffective means that there is no significant difference compared to before application of the eye care composition.

The specific test results are as follows:

It can be seen that the eye care compositions of Examples 1-3 can effectively relieve visual fatigue, and have a good effect on alleviating the tightness, fuzziness, pain and fatigue of the eyes caused by using electronic products for a long time.

Further, the storage stability of the eye care composition for relieving asthenopia of Examples 1-3 and Comparative Example 1 was tested respectively, and the specific test methods were as follows:

Put the eye care compositions for relieving visual fatigue of Examples 1-3 and Comparative Example 1 under the light environment, keep the temperature at 45°C, and after standing for 90 days, observe whether the properties of each eye care composition change, whether Separation, precipitation, precipitation and other phenomena appear. The specific test results are as follows:

It can be seen that the eye care composition for relieving visual fatigue in Examples 1-3 of the present invention uses methacrylic anhydride to pretreat sodium hyaluronate; and uses pretreatment, N-isopropylacrylamide 1. The active ingredient is used in the step of preparing the active hydrogel; the active hydrogel is combined with other specific raw materials to prepare an eye care composition for relieving visual fatigue, which is less irritating to the eyes, has no toxic and side effects, and effectively avoids functional Irritation to the eyes by ingredients such as sexual substances and preservatives, and eye discomfort that may occur after long-term use; the active ingredients of the eye care composition are easy to absorb, and can effectively relieve visual fatigue; and further improve the long-term storage stability of the eye care composition sex.

Unless otherwise specified, the percentages used in the present invention are all mass percentages.

Finally, it should be noted that: the above is only a preferred embodiment of the present invention, and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, for those skilled in the art, it still The technical solutions recorded in the foregoing embodiments may be modified, or some technical features thereof may be equivalently replaced. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included within the protection scope of the present invention.

Claims (9)

1. A method for preparing an eye care composition for relieving asthenopia, which is characterized by comprising the following steps: pretreatment, preparation of active hydrogel, preparation of eye care composition;

the pretreatment, namely adding sodium hyaluronate into deionized water, dispersing uniformly, cooling to 2-5 ℃, and keeping the temperature and standing for a certain time; regulating pH value to 8-8.5, maintaining the temperature to 2-5deg.C, and stirring for a certain time; then adding methacrylic anhydride, and carrying out heat preservation treatment for 10-12 hours at the temperature of 2-5 ℃ to obtain pretreatment liquid; adding the pretreatment liquid into absolute ethyl alcohol until no sediment is separated out, and filtering out solid matters; washing the solid with absolute ethyl alcohol, putting the solid into deionized water, stirring uniformly, and dialyzing to obtain a pretreated substance;

the active hydrogel is prepared, active ingredients are put into deionized water and stirred uniformly; then adding the pretreated matter and N-isopropyl acrylamide, and continuously stirring for a certain time; heating to 30-35 ℃ under the stirring condition in a nitrogen atmosphere, adding ammonium persulfate, and stirring for 1-3h under the heat preservation to obtain active hydrogel;

in the preparation of the active hydrogel, the active ingredients consist of the following components: fructus Siraitiae Grosvenorii extract, sweet potato leaf extract, and fructus Myrtilli extract;

the preparation of an eye care composition employs an active hydrogel to prepare an eye care composition.

2. The method for preparing the eye care composition for relieving asthenopia according to claim 1, wherein the eye care composition is prepared by adding disodium ethylenediamine tetraacetate, carbomer, hydrolyzed collagen and glycerin into sterilized deionized water, dispersing uniformly, adding active hydrogel, 1, 2-pentanediol, glycerol stearate, jojoba oil, L-serine, vitamin E, tocopheryl acetate and stearyl alcohol, and mixing uniformly.

3. The method for preparing the eye care composition for relieving asthenopia according to claim 1, wherein in the pretreatment, the weight ratio of sodium hyaluronate to deionized water is 1:95-100;

the weight ratio of the sodium hyaluronate to the methacrylic anhydride is 1:2.5-3.

4. The method for preparing the eye care composition for relieving asthenopia according to claim 1, wherein the molecular weight cut-off during the pretreatment is 10-12kDa and the dialysis treatment time is 20-24h.

5. The method for preparing the eye care composition for relieving asthenopia according to claim 1, wherein the weight ratio of the pretreatment, the N-isopropylacrylamide, the active ingredient, the ammonium persulfate and the deionized water in the preparation of the active hydrogel is 30-35:70-75:7-9:0.5-0.6:1000-1200.

6. The method for preparing the eye care composition for relieving asthenopia according to claim 1, wherein in the preparation of the active hydrogel, the weight ratio of the fructus momordicae extract to the sweet potato leaf extract to the blueberry extract in the active ingredients is 12-15:8-10:3-5.

7. The method for preparing an eye care composition for relieving asthenopia according to claim 1, wherein in the preparation of the active hydrogel, the specification of the momordica grosvenori extract is 80-100 meshes, and the extraction ratio is 10-20:1;

the specification of sweet potato leaf extract is 80-100 meshes, and the extraction ratio is 10-20:1;

the specification of the blueberry extract is 80-100 meshes, and the extraction ratio is 10-20:1.

8. The method for preparing the eye care composition for relieving asthenopia according to claim 2, wherein the weight ratio of deionized water, disodium edetate, carbomer, hydrolyzed collagen, glycerol, active hydrogel, 1, 2-pentanediol, glycerol stearate, jojoba oil, L-serine, vitamin E, tocopheryl acetate, stearyl alcohol is 40-45:0.15-0.2:0.5-0.6:2-3:4-5:40-45:6-7:2-3:0.8-1:1.5-2:0.15-0.2:0.05-0.06:0.8-1 in the eye care composition.

9. An eye care composition for relieving asthenopia, characterized by being prepared by the preparation method of any one of claims 1 to 8.