CN116525074A - Analysis method, device, equipment and storage medium of contrast medium injection rate based on intravenous injection - Google Patents

Abstract

This specification provides a contrast agent injection rate analysis method, device, equipment and storage medium based on intravenous injection, by obtaining relevant information of tomographic abnormal images and tomographic normal images based on intravenous contrast agent; The information is compared with the relevant information of the normal image to obtain the abnormal information; according to the abnormal information, the functional relationship between the injection rate of the contrast agent forming the abnormal image and the abnormal information is determined; according to the functional relationship, the injection rate of the contrast agent forming the abnormal image is calculated. Therefore, the above analysis method can accurately analyze the injection rate of the contrast agent that forms the abnormal image, and then adjust the injection rate of the contrast agent in time according to the analysis result to improve the imaging quality of the body.

Description

Analysis method, device, equipment and storage of contrast medium injection rate based on intravenous injection medium

technical field

This specification relates to the technical field of contrast media, in particular to a contrast media injection rate analysis method, device, equipment and storage medium based on intravenous injection.

Background technique

A contrast agent (also known as a contrast agent, Contrast Media) is a preparation that is injected (or taken) into the body to enhance the effect of image observation. The density of the preparation is higher or lower than that of the surrounding tissue. When used, the contrast of the body image can be increased, so that the body image can be observed more clearly. Therefore, there is an urgent need to improve the imaging quality of the body.

Contents of the invention

This specification provides a contrast medium injection rate analysis method, device, equipment and storage medium based on intravenous injection, which can help improve the imaging quality of the body.

In the first aspect, one or more embodiments of this specification provide a method for analyzing the injection rate of contrast medium based on intravenous injection, including:

Obtain information about abnormal tomographic images and normal tomographic images based on intravenous contrast agents;

Comparing the relevant information of the abnormal image with the relevant information of the normal image to obtain the abnormal information;

According to the abnormal information, determine the functional relationship between the injection rate of the contrast medium for forming the abnormal image and the abnormal information;

According to the functional relationship, the contrast agent injection rate for forming abnormal images is calculated.

According to one or more embodiments of the present specification, obtaining relevant information of abnormal tomographic images and normal tomographic images based on intravenous injection of contrast agents includes:

Select the abnormal image and the target area image in the normal image;

Get information about the image of the target area.

According to one or more embodiments of the present specification, the relevant information includes one or more of spatial resolution, density resolution, artifact, noise, and CT attenuation value.

According to one or more embodiments of the present specification, the abnormal information includes one or more of radiation hardening artifacts, particle noise, and CT attenuation values.

According to one or more embodiments of the present specification, according to the abnormal information, determining the functional relationship between the injection rate of the contrast medium for forming the abnormal image and the abnormal information includes:

Differentially process abnormal information and normal information to obtain differential information;

According to the difference information, the functional relationship between the injection rate and the difference information for forming the abnormal image is determined.

According to one or more embodiments of the present specification, the functional relationship is a positive correlation relationship.

According to one or more embodiments of this specification, the functional relationship is as follows:

Among them, V represents the injection rate, in mL/s;

SD is expressed as noise, and the unit is HU;

CT is expressed as the average value of CT attenuation value, the unit is HU;

The S _artifact is expressed as the area of the ray hardening artifact, and the unit is cm ² ;

t represents the time of the abnormal image, and the unit is s;

d represents the transmission thickness in cm.

In the second aspect, one or more embodiments of this specification provide a contrast medium injection rate analysis device based on intravenous injection, including:

An acquisition module, configured to acquire relevant information of tomographic abnormal images and tomographic normal images based on intravenous injection of contrast agents;

The comparison module is used to compare the relevant information of the abnormal image with the relevant information of the normal image to obtain the abnormal information;

A determination module, configured to determine the functional relationship between the injection rate of the contrast medium for forming the abnormal image and the abnormal information according to the abnormal information;

The calculation module is used to calculate the contrast agent injection rate for forming the abnormal image according to the functional relationship.

In a third aspect, one or more embodiments of this specification provide a contrast agent injection rate analysis device based on intravenous injection, including a memory and a processor coupled to the memory, the processor is configured to based on the According to the instruction in the instruction, the contrast agent injection rate analysis method according to the first aspect of the specification is executed.

In a fourth aspect, one or more embodiments of this specification provide a computer-readable storage medium, in which computer program instructions are stored, and when the computer program instructions are executed by a processor, the computer program instructions described in Clause 1 of this specification are implemented. In one aspect a method for analyzing a contrast agent injection rate.

The contrast medium injection rate analysis method, device, equipment and storage medium based on intravenous injection provided in this manual obtain relevant information of tomographic abnormal images and tomographic normal images based on intravenous contrast medium; combine the relevant information of abnormal images and The abnormal information is obtained by comparing the relevant information of the normal image; according to the abnormal information, the functional relationship between the injection rate of the contrast agent forming the abnormal image and the abnormal information is determined; according to the functional relationship, the injection rate of the contrast agent forming the abnormal image is calculated. Therefore, the above-mentioned analysis method can accurately analyze and obtain the injection rate of the contrast agent that forms the abnormal image, and then adjust the injection rate of the contrast agent in time according to the analysis result, so as to improve the imaging quality of the body.

Description of drawings

Various other advantages and benefits will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiment. The drawings are only for the purpose of illustrating the preferred embodiments and are not to be considered as limiting the description. Also, the same reference numerals are used to denote the same components throughout the drawings. In the attached picture:

Fig. 1 is a schematic flowchart of a contrast medium injection rate analysis method based on intravenous injection provided by one or more embodiments of the present specification;

Fig. 2 is a schematic flow chart of a contrast medium injection rate analysis method based on intravenous injection provided by one or more embodiments of the present specification;

Fig. 3 is a schematic flow chart of a contrast medium injection rate analysis method based on intravenous injection provided by one or more embodiments of the present specification;

Fig. 4 is a schematic structural diagram of a contrast medium injection rate analysis device based on intravenous injection provided by one or more embodiments of the present specification;

Fig. 5 is a schematic structural diagram of a contrast medium injection rate analysis device based on intravenous injection provided by one or more embodiments of the present specification.

The reference numerals in the specific embodiment are as follows:

10-analyzing device, 11-obtaining module, 12-comparing module, 13-determining module, 14-calculating module;

20-analysis equipment, 21-memory, 22-processor, 23-bus, 24-communication interface.

Detailed ways

Embodiments of the technical solutions of this specification will be described in detail below in conjunction with the accompanying drawings. The following examples are only used to more clearly illustrate the technical solutions of the present specification, and therefore are only examples, rather than limiting the scope of protection of the present specification.

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art of this specification; the terms used herein are only for the purpose of describing specific embodiments, and are not intended to Restrictions on this specification; the terms "comprising" and "having" and any variations thereof in the specification and claims of this specification and the above description of the drawings are intended to cover a non-exclusive inclusion.

In the description of the embodiments of this specification, technical terms such as "first" and "second" are only used to distinguish different objects, and should not be interpreted as indicating or implying relative importance or implicitly indicating the number, specificity or quantity of the indicated technical features. Sequential or primary-secondary relationship. In the description of the embodiments of this specification, "plurality" means two or more, unless otherwise specifically defined.

Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the specification. The occurrences of this phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. It is understood explicitly and implicitly by those skilled in the art that the embodiments described herein can be combined with other embodiments.

In the description of the embodiments of this specification, the term "and/or" is only an association relationship describing associated objects, which means that there may be three kinds of relationships, such as A and/or B, which may mean: A exists alone, and A exists at the same time and B, there are three cases of B alone. In addition, the character "/" in this article generally indicates that the contextual objects are an "or" relationship.

In the description of the embodiments of this specification, the term "plurality" refers to two or more (including two).

As described in the background art above, contrast agents can enhance image observation effects and are widely used in the field of medical imaging. However, in related technologies, the injection rate of the contrast agent will affect the imaging quality. For example, if the injection rate of the contrast agent exceeds or is lower than the normal injection rate, the imaging quality will be reduced, thereby affecting the judgment of the imaging. Therefore, there is an urgent need to provide a method for analyzing contrast agent injection efficiency to help improve imaging quality.

In view of this, one or more embodiments of the present specification provide a contrast agent injection rate analysis method, device, device and storage medium based on intravenous injection, which can help improve the imaging quality of the body.

The method for analyzing the injection rate of contrast medium based on intravenous injection provided by one or more embodiments of the present specification will be further described below by using computerized tomography to scan the body.

In the first aspect, please refer to FIG. 1 , one or more embodiments of the present specification provide a contrast medium injection rate analysis method based on intravenous injection, including:

S10. Obtain relevant information of abnormal tomographic images and normal tomographic images based on intravenous injection of contrast agents;

S20. Comparing the relevant information of the abnormal image with the relevant information of the normal image to obtain abnormal information;

S30. According to the abnormal information, determine the functional relationship between the injection rate of the contrast medium for forming the abnormal image and the abnormal information;

S40. Calculate and obtain a contrast agent injection rate for forming an abnormal image according to the functional relationship.

In this manual, the contrast agent is also called contrast agent, which is a kind of chemical substance that is injected or given to the patient during the examination, and it can enhance the observation effect of the image. After the contrast agent is injected intravenously, it will need to be combined with computerized tomography (X-CT or CT for short). The digital signal is calculated by the computer to calculate the attenuation coefficient of each pixel, and then the image is reconstructed, so that the tomographic structure of the human body can be displayed, that is, the above-mentioned tomographic image.

The method for analyzing the injection rate of contrast medium based on intravenous injection provided in this specification obtains relevant information of abnormal images of tomography and normal images of tomography based on intravenous injection of contrast medium; and compares the relevant information of abnormal images with the relevant information of normal images , to obtain the abnormal information; according to the abnormal information, determine the functional relationship between the contrast agent injection rate for forming the abnormal image and the abnormal information; according to the functional relationship, calculate the contrast agent injection rate for forming the abnormal image. Therefore, the above-mentioned analysis method can accurately analyze and obtain the injection rate of the contrast agent that forms the abnormal image, and then adjust the injection rate of the contrast agent in time according to the analysis result, so as to improve the imaging quality of the body.

Please refer to FIG. 2 , in one or more embodiments of the present specification, obtaining relevant information of abnormal tomographic images and normal tomographic images based on intravenous injection of contrast agent, that is, S10 may include:

S11. Selecting the abnormal image and the target area image in the normal image;

S12. Obtain relevant information of the image of the target area.

In the above-mentioned embodiments, the image of the target area is selected from each image, and the relevant information of the image of the target area is obtained, which can facilitate rapid analysis to obtain the injection rate of the contrast agent.

In one or more embodiments of the present specification, the relevant information includes one or more of spatial resolution, density resolution, artifacts, noise, and CT attenuation values.

In this specification, spatial resolution refers to the ability to distinguish subtleties at high contrast (density resolution greater than 10%), ie the ability to display the smallest volume lesions or structures.

Density resolution, also known as low contrast resolution, refers to the ability to distinguish the smallest density difference between tissues.

Artifacts refer to images that do not belong to the scanned body, or images that appear in the image because the subject does not exist.

Noise refers to the degree to which the CT value in the target area image deviates from the average value in the abnormal image.

The CT attenuation value is used to represent the relative density of tissue structures on the image.

In the above-mentioned embodiments, the relevant information includes the above-mentioned information, which can help to obtain the direct influencing factors of the abnormal image, and analyze the injection rate of the contrast agent through the influencing factors.

In one or more embodiments of the present specification, the abnormal information includes one or more of radiation hardening artifacts, particle noise, and CT attenuation values.

Please refer to FIG. 3 , in one or more embodiments of this specification, according to the abnormal information, determine the functional relationship between the injection rate of the contrast medium for forming the abnormal image and the abnormal information, that is, S30 includes:

S31. Perform differential processing on abnormal information and normal information to obtain differential information;

S32. Determine the functional relationship between the injection rate for forming the abnormal image and the difference information according to the difference information.

In one or more embodiments of this specification, the functional relationship is a positive correlation. This positive correlation can help to improve the accuracy of the obtained injection rate.

In one or more embodiments of this specification, the functional relationship is as follows:

Among them, V represents the injection rate, in mL/s;

SD is expressed as noise, and the unit is HU;

CT is expressed as the average value of CT attenuation value, the unit is HU;

The S _artifact is expressed as the area of the ray hardening artifact, and the unit is cm ² ;

t represents the time of the abnormal image, and the unit is s;

d represents the transmission thickness in cm.

In the above-mentioned embodiments, the functional relationship is as the above-mentioned formula, and the injection rate of the contrast agent can be accurately obtained, so that the injection rate can be accurately adjusted to reduce the occurrence of abnormal images.

In this specification, the relevant information of the target area, such as SD, CT, S _artifact , t, and d, can be obtained directly through the CT scanner.

In the second aspect, please refer to FIG. 4 , one embodiment or multiple embodiments of this specification provide a contrast agent injection rate analysis device 10 based on intravenous injection, including an acquisition module 11, a comparison module 12, and a determination module 13 and calculation module 14 . The obtaining module 11 is used for obtaining relevant information of abnormal tomographic images and normal tomographic images based on intravenous contrast agent injection. The comparison module 12 is used to compare the relevant information of the abnormal image with the relevant information of the normal image to obtain the abnormal information. The determination module 13 is used to determine the functional relationship between the contrast agent injection rate for forming an abnormal image and the abnormal information according to the abnormal information. The calculation module 14 is used to calculate the contrast agent injection rate for forming an abnormal image according to the functional relationship.

In one or more embodiments of the present specification, the acquisition module 11 may also be specifically configured to select an image of a target area in an abnormal image and a normal image, and acquire relevant information of the image of the target area.

In one or more embodiments of this specification, the determination module 13 can also be specifically configured to perform difference processing on abnormal information and normal information to obtain difference information; and, according to the difference information, determine the injection rate and difference information for forming an abnormal image functional relationship.

In the third aspect, please refer to FIG. 5 , one or more embodiments of this specification provide a contrast agent injection rate analysis device 20 based on intravenous injection, including a memory 21 and a processor coupled to the memory 21 22. The processor 22 is configured to execute the contrast medium injection rate analysis method according to the first aspect of the present specification based on the instructions stored in the memory 21.

Exemplarily, the memory 21 may include a high-speed random access memory (Random Access Memory, RAM), and may also include a non-volatile storage (Non-Volatile Memory, NVM), such as at least one disk storage, and may also be a USB flash drive , mobile hard disk, read-only memory, magnetic disk or optical disk, etc.

Optionally, the memory 21 can be independent or integrated with the processor 22 . When the memory 21 is a device independent of the processor 22 , the analysis device 20 may further include a bus 23 for connecting the memory 21 and the processor 22 .

Exemplarily, the bus 23 may be an Industry Standard Architecture (Industry Standard Architecture, ISA) bus, a Peripheral Component Interconnect (PCI) bus, or an Extended Industry Standard Architecture (Extended Industry Standard Architecture, EISA) bus, etc. The bus can be divided into address bus, data bus, control bus and so on. For ease of illustration, the bus 23 in Fig. 5 of this specification is not limited to only one bus or one type of bus.

Please continue to refer to FIG. 5 , in one or more embodiments of the present specification, the analysis device 20 may further include a communication interface 24 , and the communication interface 24 may be connected to the processor 22 through the bus 23 . The processor 22 can realize communication with various devices by controlling the communication interface 24 .

Please continue to refer to FIG. 5 , in one or more embodiments of the present specification, the analysis device 20 may further include a display screen 25 , and the display screen 25 may be connected to the processor 22 through the bus 23 .

In a fourth aspect, one or more embodiments of this specification provide a computer-readable storage medium, in which computer program instructions are stored, and when the computer program instructions are executed by a processor, the computer program instructions described in Clause 1 of this specification are implemented. In one aspect a method for analyzing a contrast agent injection rate.

Wherein, the computer-readable storage medium may be a computer storage medium or a communication medium. Communication media includes any medium that facilitates transfer of a computer program from one place to another. Computer storage media can be any available media that can be accessed by a general purpose or special purpose computer. For example, a computer-readable storage medium is coupled to the processor such that the processor can read information from, and write information to, the computer-readable storage medium. Of course, the computer-readable storage medium can also be an integral part of the processor. The processor and the computer-readable storage medium may reside in application specific integrated circuits (Application Specific Integrated Circuits, ASIC). Additionally, the ASIC may be located in the user equipment. Of course, the processor and the computer-readable storage medium can also exist in the communication device as discrete components.

The above-mentioned computer-readable storage medium can be realized by any type of volatile or non-volatile storage device or their combination, such as Static Random-Access Memory (Static Random-Access Memory, SRAM), Electrically Erasable and Programmable Electrically-Erasable Programmable Read-Only Memory (EEPROM), Erasable Programmable Read Only Memory (EPROM), Programmable Read-Only Memory (PROM), only Read memory (Read-OnlyMemory, ROM), magnetic memory, flash memory, magnetic disk or optical disk. A storage media may be any available media that can be accessed by a general purpose or special purpose computer.

In some embodiments provided in this specification, it should be understood that the disclosed devices and methods can be implemented in other ways. For example, the device embodiments described above are only illustrative. For example, the division of modules is only a logical function division. In actual implementation, there may be other division methods. For example, multiple modules can be combined or integrated into another A system, or some feature, can be ignored, or not implemented. In another point, the mutual coupling or direct coupling or communication connection shown or discussed may be through some interfaces, and the indirect coupling or communication connection of devices or modules may be in electrical, mechanical or other forms.

A module described as a separate component may or may not be physically separated, and a component shown as a module may or may not be a physical unit, that is, it may be located in one place, or may be distributed to multiple network units. Part or all of the modules can be selected according to actual needs to achieve the purpose of the solution of this embodiment.

In addition, each functional module in each embodiment of this specification may be integrated into one processing unit, each module may exist separately physically, or two or more modules may be integrated into one unit. The units formed by the above modules can be implemented in the form of hardware, or in the form of hardware plus software functional units.

The above-mentioned integrated modules implemented in the form of software function modules can be stored in a computer-readable storage medium. The above-mentioned software function modules are stored in a storage medium, and include several instructions to enable a computer device (which may be a personal computer, server, or network device, etc.) or a processor to execute some steps of the methods in various embodiments of this specification.

Those of ordinary skill in the art can understand that all or part of the steps for implementing the above method embodiments can be completed by program instructions and related hardware. The aforementioned program can be stored in a computer-readable storage medium. When the program is executed, the steps including the above-mentioned method embodiments are executed. The aforementioned storage medium includes various media capable of storing program codes such as ROM, RAM, magnetic disk or optical disk.

Example

The following examples describe the content disclosed in the present application more specifically, and these examples are for illustrative purposes only, since various modifications and changes within the scope of the disclosed content of the application will be apparent to those skilled in the art. Unless otherwise stated, all reagents used in the following examples are commercially available or synthesized according to conventional methods, and can be used directly without further treatment, and the instruments used in the examples are all commercially available.

Example 1

This embodiment provides a method for analyzing the injection rate of contrast medium based on intravenous injection, including:

(1) Select the abnormal image and the target area image in the normal image;

(2) Obtain relevant information of the image of the target area;

(3) comparing the relevant information of the abnormal image with the relevant information of the normal image to obtain the abnormal information;

(4) Differentially process abnormal information and normal information to obtain differential information, as shown in Table 1;

(5) According to the difference information, determine the functional relationship between the injection rate for forming the abnormal image and the difference information, wherein the functional relationship is as follows: Among them, V represents the injection rate, the unit is mL/s; SD represents the noise, the unit is HU; CT represents the average value of CT attenuation value, the unit is HU; S _artifact represents the area of the radiation hardening artifact, the unit is cm ² ; t represents the time of the abnormal image, the unit is s; d represents the transmission thickness, the unit is cm;

(6) According to the functional relationship, the injection rate of the contrast medium for forming the abnormal image is calculated, as shown in Table 1.

Example 2-5

The difference from Embodiment 1 is that the selected target area is different.

comparative example

This comparative example uses a flow meter to measure the injection rate of the contrast agent.

Table 1 lists the abnormal information in abnormal images and normal images, and the contrast agent injection rate in normal images, respectively.

Table 1

According to Table 1, the above-mentioned analysis method can accurately analyze the injection rate of the contrast agent that forms the abnormal image. Therefore, the injection rate of the contrast agent can be adjusted in time according to the analysis results to improve the imaging quality of the body.

Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this specification, rather than to limit them. Although the specification has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that: it is still possible to modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements for some or all of the technical features. . However, these modifications or replacements do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments in this specification.

Claims (10)

1. A contrast medium injection rate analysis method based on intravenous injection, characterized in that, comprising: Obtain information about abnormal tomographic images and normal tomographic images based on intravenous contrast agents; Comparing the relevant information of the abnormal image with the relevant information of the normal image to obtain abnormal information; determining a functional relationship between a contrast agent injection rate for forming the abnormal image and the abnormal information according to the abnormal information; According to the functional relationship, the contrast agent injection rate for forming the abnormal image is calculated. 2. The contrast medium injection rate analysis method according to claim 1, wherein said acquiring relevant information of abnormal tomographic images and normal tomographic images based on intravenous injection of contrast medium comprises: selecting an image of a target area in the abnormal image and the normal image; Relevant information of the target area image is acquired. 3. The contrast agent injection rate analysis method according to claim 1 or 2, wherein the relevant information includes one or more of spatial resolution, density resolution, artifacts, noise, and CT attenuation values . 4. The contrast medium injection rate analysis method according to claim 1, wherein the abnormal information includes one or more of radiation hardening artifacts, particle noise, and CT attenuation values. 5. The contrast medium injection rate analysis method according to claim 1, characterized in that, according to the abnormal information, determining the functional relationship between the contrast medium injection rate for forming the abnormal image and the abnormal information comprises: performing differential processing on the abnormal information and normal information to obtain differential information; According to the difference information, a functional relationship between the injection rate for forming the abnormal image and the difference information is determined. 6 . The contrast medium injection rate analysis method according to claim 5 , wherein the functional relationship is a positive correlation. 7. The contrast medium injection rate analysis method according to claim 5 or 6, wherein the functional relationship is as follows: Among them, V represents the injection rate, in mL/s; SD is expressed as noise, and the unit is HU; CT is expressed as the average value of CT attenuation value, the unit is HU; The S _artifact is expressed as the area of the ray hardening artifact, and the unit is cm ² ; t represents the time of the abnormal image, and the unit is s; d represents the transmission thickness in cm. 8. A contrast agent injection rate analysis device based on intravenous injection, characterized in that it comprises: An acquisition module, configured to acquire relevant information of tomographic abnormal images and tomographic normal images based on intravenous injection of contrast agents; A comparison module, configured to compare the relevant information of the abnormal image with the relevant information of the normal image to obtain abnormal information; A determining module, configured to determine the functional relationship between the contrast agent injection rate for forming the abnormal image and the abnormal information according to the abnormal information; The calculation module is used to calculate the contrast agent injection rate for forming the abnormal image according to the functional relationship. 9. A contrast medium injection rate analysis device based on intravenous injection, characterized in that it comprises: memory; and, A processor coupled to the memory, the processor configured to execute the contrast agent injection rate analysis method according to any one of claims 1 to 5 based on instructions stored in the memory. 10. A computer-readable storage medium, wherein computer program instructions are stored in the computer-readable storage medium, and when the computer program instructions are executed by a processor, the computer program instructions described in any one of claims 1 to 5 are implemented. Contrast agent injection rate analysis method.