CN116413247A - Cleaning device for pipetting needle and sample analyzer - Google Patents

Abstract

The invention provides a cleaning device for pipetting needles, comprising: a body part; a first cleaning mechanism formed inside the body part, the first cleaning mechanism is provided with a first cleaning tank; The second cleaning mechanism inside the body part, the second cleaning mechanism is provided with a second cleaning tank; wherein, the pipette needle can be put into the first cleaning tank, and the pipetting needle can be cleaned by the first cleaning mechanism. The outer wall of the liquid needle is cleaned and can be put into the second cleaning tank, and the inner wall of the pipetting needle is cleaned by the second cleaning mechanism. The invention also provides a sample analyzer.

Description

Cleaning device and sample analyzer for pipetting needle

technical field

The invention belongs to the technical field of detection equipment, and in particular relates to a cleaning device and a sample analyzer for pipetting needles.

Background technique

Sample analyzer (biochemical analysis, immune analyzer) is an instrument used to detect specific substances in blood. Sample analyzers commonly used in testing equipment are usually equipped with pipettes, which are important equipment on medical analysis instruments, which are used to suck and release testing fluids required for testing, such as samples, reagents, diluents and General fluid etc. At present, most analytical instruments use hollow steel needles to transfer liquids, and in order to avoid cross-contamination between fluids, corresponding cleaning devices are usually provided to clean the steel needles. This means that the steel needle must be fully cleaned before each transfer of liquid to prevent cross-contamination of reagents or samples.

In the existing pipette cleaning system, the inside of the pipette needle can usually be connected with a purified water pipeline, which can rinse the inner wall of the pipette needle when there is no special need. However, the existing pipette cleaning system has a single flushing mode, which can only be cleaned with purified water or cleaning solution alone, and it is impossible to clean the inner and outer walls of the pipette needle with different cleaning solutions. This results in limited applicability and low cleaning efficiency, which is not conducive to the improvement of the detection efficiency of the sample analyzer.

Contents of the invention

In view of the above technical problems, the present invention aims to propose a cleaning device and a sample analyzer for pipetting needles, the cleaning device can provide different washing solutions and flushing modes for the inner wall and outer wall of the pipetting needle, And the pipetting needle can be fully cleaned, which is very beneficial to improving the cleaning effect and cleaning efficiency of the pipetting needle.

Therefore, according to the first aspect of the present invention, a cleaning device for pipetting needles is provided, comprising: a body part; a first cleaning mechanism formed inside the body part, and the first cleaning mechanism is provided with The first cleaning tank; the second cleaning mechanism formed inside the body part, the second cleaning mechanism is provided with a second cleaning tank; wherein, the pipetting needle can be put into the first cleaning tank, through the The first cleaning mechanism cleans the outer wall of the pipetting needle, and can be put into the second cleaning tank, and the inner wall of the pipetting needle is cleaned by the second cleaning mechanism.

In one embodiment, the first cleaning mechanism includes an upper cover seat arranged at the first end of the first cleaning tank, and a through hole communicating with the first cleaning tank is provided in the middle of the upper cover seat , for inserting the pipetting needle to be cleaned, wherein the upper cover seat is configured to generate a differential pressure water flow to clean the outer wall of the pipetting needle.

In one embodiment, a first liquid inlet is provided on the side wall area of the body part corresponding to the upper cover seat, and a first liquid waste interface is provided at the second end of the first cleaning tank.

In one embodiment, the upper cover seat is configured to include a cylindrical body portion and an annular protrusion extending radially outward, the annular protrusion is formed at a first end of the cylindrical body portion, the The first end of the first cleaning tank is configured as a stepped counterbore, and the upper cover seat is fitted with the stepped counterbore.

In one embodiment, an annular groove is provided on the outer wall of the cylindrical main part, thereby forming an annular cavity between the upper cover seat and the inner wall of the first cleaning tank, and the cylindrical main part The side wall area corresponding to the annular groove is provided with a plurality of through holes uniformly distributed along the circumferential direction, the annular cavity communicates with the through hole through the through holes, and the inner diameter of the through holes is smaller than the The inner diameter of the first liquid inlet, wherein the first liquid inlet communicates with the annular cavity, and the cleaning liquid from the first liquid inlet enters the annular cavity and forms a node through the through hole Flow pressure difference, so as to form jet cascading washing flow in the through hole.

In one embodiment, seals spaced apart from each other in the axial direction are provided between the upper cover seat and the first cleaning tank, and the seals are respectively located at two axial ends of the annular cavity. side.

In one embodiment, the second cleaning tank is configured as a blind hole extending axially along the body portion, and a second liquid inlet is provided at the second end of the second cleaning tank.

In one embodiment, the second cleaning mechanism further includes an overflow tank axially penetrating through the body part, the first end of the overflow tank and the first end of the second cleaning tank are formed through a communication hole The second end of the overflow tank is provided with a second waste liquid interface, wherein the cleaning liquid from the second liquid inlet can be sucked into the inside of the pipetting needle to be cleaned after entering the second cleaning tank , to clean the inner wall of the pipetting needle, and the cleaned waste liquid is spit out of the pipetting needle and moves upward along the second cleaning tank to enter the overflow tank through the communication hole.

In one embodiment, the inner diameter of the overflow tank is larger than the inner diameter of the second cleaning tank.

In one embodiment, an axially inward counterbore is provided at the first end of the body portion, and both the second cleaning tank and the overflow tank are formed at the bottom of the counterbore.

According to a second aspect of the present invention, there is provided a sample analyzer, comprising the cleaning device as described above, and the cleaning device is arranged at a position corresponding to the pipetting needle in the sample analyzer.

In one embodiment, the sample analyzer is a chemiluminescence analyzer, especially a light-activated chemiluminescence analyzer.

Compared with the prior art, the advantages of the present application are:

The washing device for pipetting needles according to the present invention can provide different washing liquids and washing modes for washing the inner wall and outer wall of the pipetting needle through the first washing mechanism and the second washing mechanism. The cleaning device can fully clean the inner and outer walls of the pipetting needle, which is very beneficial to ensure the cleaning effect of the pipetting needle, and can greatly improve the cleaning efficiency of the pipetting needle. As a result, cross-contamination between fluids can be effectively avoided, and the accuracy and detection efficiency of subsequent detection tests of the sample analyzer can be ensured. In addition, the cleaning device is simple in structure, small in size, easy to operate, and low in cost.

Description of drawings

The present invention will be described below with reference to the accompanying drawings.

Fig. 1 schematically shows the external structure of the cleaning device for pipetting needles according to the present invention.

Fig. 2 is a top view of the cleaning device shown in Fig. 1 .

Fig. 3 is a sectional view along line A-A in Fig. 2 .

Fig. 4 schematically shows the structure of the upper cover seat in the first cleaning mechanism shown in Fig. 3 .

Fig. 5 is a sectional view along line B-B in Fig. 2 .

In this application, all drawings are schematic drawings, merely illustrating the principles of the invention and not drawn to true scale.

Detailed ways

The present invention is introduced below by accompanying drawing.

In the present application, it should be noted that the directional terms or qualifiers "upper", "lower" and the like used in the present application all refer to the attached drawing 1 . They are not intended to define the absolute positions of the parts involved, but may vary on a case-by-case basis.

1 and 2 schematically show the external structure of a cleaning device 100 for pipetting needles according to the present invention. As shown in FIGS. 1 and 2 , the cleaning device 100 includes a body part 1 , a first cleaning mechanism 2 formed inside the body part 1 , and a second cleaning mechanism 3 formed inside the body part 1 . The first cleaning mechanism 2 includes a first cleaning tank 20 (see FIG. 3 ) distributed along the axial extension of the main body portion 1, and the second cleaning mechanism 3 includes a second cleaning tank 30 distributed along the axial extension of the main body portion 1 (see FIG. Figure 4). The pipetting needle 200 (reagent needle) can be put into the first cleaning tank 20, the outer wall of the pipetting needle 200 is cleaned by the first cleaning mechanism 2, and the pipetting needle 200 can be put into the second cleaning tank 30 , the inner wall of the pipetting needle 200 is cleaned by the second cleaning mechanism 3 . Thus, the cleaning device 100 can provide different cleaning modes for the outer wall and/or the inner wall of the pipette needle 200 .

In one embodiment, as shown in FIG. 2 , the body part 1 can be configured as a rectangular parallelepiped. The first cleaning mechanism 2 and the second cleaning mechanism 3 are arranged in parallel inside the body part 1, and they are distributed parallel to each other. This structure is very beneficial to improving the compactness of the cleaning device 100 and reducing the overall volume of the cleaning device 100 .

FIG. 3 schematically shows a cross-sectional view of the first cleaning mechanism 2 . As shown in FIG. 3 , the first cleaning mechanism 2 further includes an upper cover seat 23 disposed on the first end of the first cleaning tank 20 (the upper end in FIG. 3 ). A through hole 231 communicated with the first cleaning tank 20 is provided in the middle of the upper cover base 23 , and the through hole 231 extends axially through the upper cover base 23 for inserting the pipetting needle 200 to be cleaned. The upper cover seat 23 is configured to generate differential pressure water flow to clean the outer wall of the pipetting needle 200 .

According to the present invention, the first cleaning mechanism 2 further includes a first liquid inlet 21 and a first waste liquid interface 22 . As shown in FIG. 3 , the first liquid inlet 21 is arranged on the side wall area of the body part 1 corresponding to the upper cover seat 23 for connecting the liquid inlet pipe. The first waste liquid interface 22 is arranged at the second end (the lower end in FIG. 3 ) of the first cleaning tank 20 and is used for connecting a waste liquid pipe. Thus, the first liquid inlet 21 is arranged at a position close to the inlet of the pipette needle.

The cleaning liquid used by the first cleaning mechanism 2 is, for example, purified water, which can be passed through the first liquid inlet 21 to rinse the outer wall of the pipetting needle 200 . Of course, the cleaning liquid can also be a specially configured washing liquid. Thus, in the case of a flushing pipeline inside the pipetting needle 2000, the simultaneous flushing of the inner and outer walls can be realized in the first cleaning mechanism.

As shown in FIG. 4 , the upper cover seat 23 is configured to include a cylindrical body portion 234 and an annular protrusion 235 extending radially outward. The annular protrusion 235 is formed at a first end of the cylindrical body portion 234 . The through holes 231 extend along the central axis of the cylindrical body portion 234 . At the same time, the first end of the first cleaning tank 20 is configured as a stepped counterbore, and the upper cover seat 23 is fitted with the stepped counterbore. The lower end surface of the annular protrusion 235 abuts against the first step surface of the stepped counterbore, the upper end surface of the annular protrusion 235 is flush with the upper end surface of the body part 1, and the lower end surface of the cylindrical main body part 234 leans against The second step surface of the stepped counterbore.

According to the present invention, an annular groove 236 is formed on the outer wall of the cylindrical body portion 234 , thereby forming an annular cavity 24 between the upper cover seat 23 and the inner wall of the first cleaning tank 23 . The first liquid inlet 21 communicates with the annular cavity 24 . A plurality of through holes 232 uniformly distributed in the circumferential direction are provided on the side wall area of the cylindrical main body portion 234 corresponding to the annular groove 236, and the annular cavity 24 communicates with the through hole 231 through the through holes 232, so as to communicate with the first cleaning The groove 23 forms communication. Preferably, a plurality of through holes 232 may be arranged to be distributed at 90 degrees in the circumferential direction.

The inner diameter of the through hole 232 is much smaller than the inner diameter of the first liquid inlet 21 . Thus, after the cleaning liquid (purified water) from the first liquid inlet 21 enters the annular cavity 24, it can form a throttling pressure difference through the through hole 232, and then form a high-pressure water flow, thereby forming a jet in the through hole 231. waterfall wash flow. The high-pressure water flow can fully wash the outer wall of the pipetting needle 200 inserted into the first cleaning tank 23 . The cleaned waste liquid goes down the first cleaning tank 23 until it reaches the first waste liquid interface 22 and is discharged.

In one embodiment, seals spaced apart from each other in the axial direction are provided between the upper cover seat 23 and the first cleaning tank 20 , and the seals are located on both axial sides of the annular cavity 23 . In the embodiment shown in FIG. 3 , the seals are respectively disposed between the outer wall of the cylindrical body portion 234 and the inner wall of the first cleaning tank 20 . During installation, the seal is compressed under radial pressure. This can effectively ensure the sealing of the annular cavity 24 , thereby ensuring the formation of a high-pressure water jet, which is beneficial to enhancing the cleaning effect on the outer wall of the pipetting needle 200 .

According to the present invention, as shown in FIG. 5 , the second cleaning tank 30 is configured as a blind hole extending axially from the upper end surface of the body part 1 , and at the second end of the second cleaning tank 20 (the lower end in FIG. 5 ) A second liquid inlet 31 is provided for connecting the cleaning liquid inlet pipe. The second cleaning mechanism 3 also includes an overflow tank 33 passing through the body part 1 in the axial direction, and the first end (the upper end in FIG. 5 ) of the second cleaning tank 30 and the first end of the overflow tank 33 are formed by a communication hole 34 connected. Meanwhile, a second waste liquid interface 32 is provided at the second end of the overflow tank 33 for connecting a waste liquid pipe.

In this embodiment, the inner diameter of the overflow tank 33 is larger than the inner diameter of the second cleaning tank 30 .

In one embodiment, an axially inward counterbore 35 is provided at the first end of the body part 1 , and the second cleaning tank 30 and the overflow tank 33 are both formed at the bottom of the counterbore 35 . The counterbore 25 is preferably arranged in an oval shape. This can increase the overflow area to prevent the upwelling waste liquid from flowing out of the second cleaning mechanism 3 .

The cleaning liquid used by the second cleaning mechanism 3 is, for example, a special cleaning liquid. During use, after the cleaning solution from the second liquid inlet 31 enters the second cleaning tank 30, it can be sucked into the inside of the pipette needle to be cleaned, so as to clean the inner wall of the pipette needle, and the waste liquid after cleaning is spit out from the pipette needle. Since the bottom of the second cleaning tank 30 is continuously filled with new cleaning liquid, the spit out waste liquid moves upwards along the second cleaning tank 30 until it enters the overflow tank 3 through the communication hole 34, and then passes through the second waste liquid interface. 32 discharge.

When the washing liquid in the internal pipeline of the pipetting needle is not enough to meet the cleaning requirements for the pipetting needle, the second cleaning tank can provide special washing liquid for the inner wall of the pipetting needle, so that the cleaning of the pipetting needle can meet the requirements. Thus, at least three washing liquids, ie, three washing modes, are provided for one pipetting needle by means of the first washing tank, the second washing tank and the internal pipeline of the pipetting needle.

According to the present invention, the first liquid inlet 21 and the second liquid inlet 31 are located on the same side of the body part 1 , and the first liquid waste port 22 and the second waste liquid port 32 are jointly arranged at the bottom of the body part 1 . This structure is very convenient for the connection of the cleaning liquid line and the waste liquid line. Thus, the cleaning device 100 can provide different cleaning liquids and cleaning modes for the inner wall and the outer wall of the pipetting needle 200 through the first cleaning mechanism 2 and the second cleaning mechanism, so as to ensure the cleaning effect on the pipetting needle.

The invention also provides a sample analyzer. The sample analyzer includes the above cleaning device 100 . In addition, the sample analyzer may include an analyzer body, the pipette may be a part of the analyzer body, and the pipette is equipped with a pipette needle, and the cleaning device 100 is used for cleaning the pipette needle. The sample analyzer can be, for example, a chemiluminescence analyzer.

A method of cleaning the pipetting needle 200 using the cleaning device 100 for a pipetting needle according to the present invention is as follows.

When in use, usually, the inside of the pipetting needle 200 can be connected with a purified water pipeline for rinsing the inner wall of the pipetting needle 200 when there is no special need. In this case, it is only necessary to use the first cleaning mechanism 2 of the cleaning device 100 to rinse the outer wall of the pipetting needle 200 .

And under designated circumstances, instead of using the purified water inside the pipetting needle 200 to rinse the inner wall of the pipetting needle 200, the pipetting needle 200 is first inserted into the second cleaning tank 30 of the second cleaning mechanism 3 to make the pipetting needle 200 sucks the cleaning liquid from the second cleaning tank 30 to wash its inner wall. The cleaning liquid flows into the second cleaning tank 30 from the second liquid inlet 31 and surges upwards, the pipetting needle 200 absorbs the cleaning liquid to clean the inner wall of the pipetting needle 200, and the waste liquid after cleaning flows from the end of the pipetting needle 200 spit out. Since the bottom of the second cleaning tank 30 is continuously filled with new cleaning liquid, the spit out waste liquid moves upwards along the second cleaning tank 30 until it enters the overflow tank 3 through the communication hole 34, and then passes through the second waste liquid interface. 32 discharge.

After the inner wall of the pipetting needle 200 is rinsed, the pipetting needle 200 is inserted into the first cleaning mechanism 2 , and the outer wall of the pipetting needle 200 is washed by high-pressure water flow. After the cleaning liquid (purified water) in the first liquid inlet 21 enters the annular cavity 24, it forms a throttling pressure difference through the through hole 232, and then forms a high-pressure water flow, thereby forming a jet waterfall washing flow. The high-pressure water flow fully washes the outer wall of the pipetting needle 200 inserted into the first cleaning tank 23 . The cleaned waste liquid goes down the first cleaning tank 23 until it reaches the first waste liquid interface 22 and is discharged. Thus, the inner wall and the outer wall of the pipetting needle 200 are cleaned by the second cleaning mechanism 3 and the first cleaning mechanism 2 in sequence, so as to realize sufficient cleaning of the pipetting needle 200 .

Of course, the pipetting needle can also be inserted into the first cleaning tank to clean the outer wall, and then inserted into the second cleaning tank to clean the inner wall. This application does not specifically limit it.

The washing device 100 for pipetting needles according to the present invention can provide different washing liquids and washing modes for washing the inner wall and outer wall of the pipetting needle 200 through the first washing mechanism 2 and the second washing mechanism 3 . The cleaning device 100 can fully clean the inner and outer walls of the pipetting needle, which is very beneficial to ensure the cleaning effect of the pipetting needle, and can greatly improve the cleaning efficiency of the pipetting needle. As a result, cross-contamination between fluids can be effectively avoided, and the accuracy and detection efficiency of subsequent detection tests of the sample analyzer can be ensured. In addition, the cleaning device 100 is simple in structure, small in size, easy to operate, and low in cost.

In the description of the present invention, it should be understood that the terms "first" and "second" are used for description purposes only, and cannot be interpreted as indicating or implying relative importance or implicitly indicating the quantity of indicated technical features. Thus, a feature defined as "first" and "second" may explicitly or implicitly include one or more of these features. In the description of the present invention, "plurality" means two or more, unless otherwise specifically defined.

In the present invention, unless otherwise clearly specified and limited, terms such as "installation", "connection", "connection" and "fixation" should be understood in a broad sense, for example, it can be a fixed connection or a detachable connection , or integrally connected; it may be mechanically connected or electrically connected; it may be directly connected or indirectly connected through an intermediary, and it may be the internal communication of two components. Those of ordinary skill in the art can understand the specific meanings of the above terms in the present invention according to specific situations.

In the description of this specification, descriptions referring to the terms "one embodiment", "some embodiments", "example", "specific examples", or "some examples" mean that specific features described in connection with the embodiment or example , structure, material or characteristic is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

Finally, it should be noted that the above descriptions are only preferred embodiments of the present invention, and do not constitute any limitation to the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can modify the technical solutions described in the aforementioned embodiments, or perform equivalent replacements for some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included within the protection scope of the present invention.

Claims (12)

1. A cleaning device for a pipetting needle comprising:

a body portion (1);

a first cleaning mechanism (2) formed inside the body portion, the first cleaning mechanism being provided with a first cleaning tank (20);

a second cleaning mechanism (3) formed inside the body portion, the second cleaning mechanism being provided with a second cleaning tank (30);

wherein the pipetting needle can be placed in the first cleaning tank, the outer wall of the pipetting needle is cleaned by the first cleaning mechanism, and can put into the second cleaning tank, through the second wiper mechanism to the inner wall of pipetting needle washs.

2. The cleaning device according to claim 1, wherein the first cleaning mechanism comprises an upper cover seat (23) provided at a first end of the first cleaning tank, a through hole (231) communicating with the first cleaning tank is provided in a middle portion of the upper cover seat for inserting a pipetting needle to be cleaned,

wherein, the upper cover seat is constructed to can produce pressure differential rivers to wash the outer wall of pipetting needle.

3. A cleaning device according to claim 2, characterized in that a first liquid inlet (21) is provided in the body portion in the region of the side wall corresponding to the upper cover seat, and a first waste liquid interface (22) is provided at the second end of the first cleaning tank.

4. The cleaning device of claim 3, wherein the upper cap seat is configured to include a cylindrical body portion (234) and a radially outwardly extending annular projection (235) formed at a first end of the cylindrical body portion,

the first end of the first cleaning tank is configured into a stepped countersink, and the upper cover seat and the stepped countersink form fit installation.

5. The cleaning apparatus according to claim 4, wherein an annular groove (236) is provided in an outer wall of the cylindrical body portion so as to form an annular cavity (24) between the upper cover seat and an inner wall of the first cleaning tank, a plurality of through holes (232) are provided in a sidewall region of the cylindrical body portion corresponding to the annular groove, the annular cavity communicates with the through holes through the through holes, and an inner diameter of the through holes is smaller than an inner diameter of the first liquid inlet,

the first liquid inlet is communicated with the annular cavity, and cleaning liquid from the first liquid inlet enters the annular cavity and forms throttling pressure difference through the through hole, so that sprayed waterfall type cleaning flow is formed in the through hole.

6. The cleaning apparatus of claim 5, wherein seals are disposed between the upper cover base and the first cleaning tank and are axially spaced apart from each other, the seals being on axially opposite sides of the annular cavity.

7. The washing device according to claim 1, characterized in that the second washing tank is configured as a blind hole extending axially along the body portion, and that a second liquid inlet (31) is provided at a second end of the second washing tank.

8. The cleaning apparatus according to claim 7, wherein the second cleaning mechanism further comprises an overflow tank (33) penetrating the body portion in the axial direction, a first end of the overflow tank being in communication with a first end of the second cleaning tank via a communication hole (34), a second end of the overflow tank being provided with a second waste liquid interface (32),

the cleaning liquid from the second liquid inlet enters the second cleaning tank and can be sucked into the to-be-cleaned pipetting needle so as to clean the inner wall of the pipetting needle, and the cleaned waste liquid is ejected from the pipetting needle and moves upwards along the second cleaning tank until entering the overflow tank through the communication hole.

9. The cleaning apparatus of claim 7 or 8, wherein an inner diameter of the overflow trough is greater than an inner diameter of the second cleaning trough.

10. The cleaning apparatus defined in claim 9, wherein a counterbore (35) is provided axially inward at the first end of the body portion, the second cleaning tank and the overflow tank each being formed in a bottom portion of the counterbore.

11. A sample analyzer comprising the cleaning device according to any one of claims 1 to 10, which is provided in the sample analyzer at a position corresponding to a pipetting needle.

12. The sample analyzer of claim 11, wherein the sample analyzer is a chemiluminescent analyzer.

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