CN116297444B - Device for assisting three-dimensional image equipment in chromosome abnormality detection - Google Patents
Device for assisting three-dimensional image equipment in chromosome abnormality detection Download PDFInfo
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- CN116297444B CN116297444B CN202310047385.6A CN202310047385A CN116297444B CN 116297444 B CN116297444 B CN 116297444B CN 202310047385 A CN202310047385 A CN 202310047385A CN 116297444 B CN116297444 B CN 116297444B
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- 208000031404 Chromosome Aberrations Diseases 0.000 title claims abstract description 23
- 206010067477 Cytogenetic abnormality Diseases 0.000 title claims abstract description 16
- 238000001514 detection method Methods 0.000 title claims abstract description 10
- 238000013016 damping Methods 0.000 claims abstract description 40
- 238000000926 separation method Methods 0.000 claims abstract description 29
- 239000012530 fluid Substances 0.000 claims abstract description 28
- 230000035939 shock Effects 0.000 claims abstract description 28
- 230000005540 biological transmission Effects 0.000 claims abstract description 21
- 238000003384 imaging method Methods 0.000 claims description 27
- 239000011521 glass Substances 0.000 claims description 19
- 239000000758 substrate Substances 0.000 claims description 14
- 239000011159 matrix material Substances 0.000 claims description 8
- 206010008805 Chromosomal abnormalities Diseases 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 239000012528 membrane Substances 0.000 claims description 4
- 239000013013 elastic material Substances 0.000 claims 1
- 125000003003 spiro group Chemical group 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 abstract description 10
- 238000005286 illumination Methods 0.000 description 9
- 239000006096 absorbing agent Substances 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 6
- 230000003139 buffering effect Effects 0.000 description 3
- 210000000349 chromosome Anatomy 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 230000005856 abnormality Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 210000005069 ears Anatomy 0.000 description 2
- 238000004321 preservation Methods 0.000 description 2
- 239000012780 transparent material Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0106—General arrangement of respective parts
- G01N2021/0112—Apparatus in one mechanical, optical or electronic block
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Robotics (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a device for assisting three-dimensional image equipment in chromosome abnormality detection, which comprises a microscopic scanning assembly, a detection module and a detection module, wherein the microscopic scanning assembly is used for detecting chromosome abnormality; the damping base is provided with a damping base body, a damping pad is arranged below the damping base body, the damping pad is provided with a hollow columnar structure, the damping pad is provided with a main shell, one end part of the main shell is provided with a screw connection part, an upper separation plate and a lower separation plate are arranged inside the main shell, the inside of the main shell is separated into a main fluid cavity and a secondary fluid cavity by the upper separation plate and the lower separation plate, the main fluid cavity is positioned above the secondary fluid cavity, overflow holes are formed in the upper separation plate and the lower separation plate, a diaphragm is arranged below the lower separation plate, and the edge of the diaphragm is fixedly connected with the inner side wall of the main shell; according to the invention, through the arrangement of the damping base, the mechanical shock of the microscopic scanning assembly is reduced, and the damping pad can be utilized to enable staff to timely obtain early warning of abnormal mechanical structure, so that stable transmission of a slide sample and protection of an experimental sample are ensured.
Description
Technical Field
The invention relates to the technical field of medical detection instruments, in particular to a device for assisting three-dimensional image equipment in detecting chromosome abnormality.
Background
In recent years, with rapid development of digital imaging hardware and software, sample digitization technology has also advanced, and is gradually applied to medical diagnosis and teaching, sample digitization uses image acquisition technology, microscope technology, electric automation technology and computer technology to seamlessly splice acquired images of multiple fields of view, and further a complete digitized pathological image is obtained, the technology is called full slide scanning, and due to development of full slide digitization, it is possible to acquire digitized sample data with high resolution and large size, and staff can complete digitization of samples within several minutes using a full slide scanning system and store the results in a hard disk, and can observe samples directly through a display.
The prior art discloses an automated slide scanning system for microscopes (US 20130222895 A1) comprising an autofocus unit which is simple and provides fine adjustment of the focusing tube without any gap, said focusing unit comprising a block cut or manufactured in a pattern forming a head to support the focusing tube, and at least one elongated and rigid arm projecting perpendicularly from said head, one end of said at least one arm being integrally joined with said head, said focusing unit further comprising an elongated rigid rod substantially parallel to and spaced apart from said at least one arm, the lever being pivotally mounted to the hinge and having a first end and a second free end connected to the head of the focusing unit, said focusing unit further comprising a drive mechanism having rollers coupled to a motor, the scanning system of the invention being suitable for automated or pre-screening of samples; however, the slide scanning device also has the problem of mechanical vibration caused by a transmission system, so that a device for assisting the three-dimensional image device in detecting chromosome abnormality is needed to solve the technical problem.
Disclosure of Invention
The invention aims to provide a device for assisting a three-dimensional image device in detecting chromosome abnormality, which aims to solve the problems that imaging quality is affected by mechanical vibration, abnormality of a transmission mechanism is not easy to find in time and light supplementing effect of a light source is poor.
In order to achieve the above purpose, the present invention provides the following technical solutions: an apparatus for assisting a three-dimensional imaging device in detecting chromosomal abnormalities, comprising, a microscanning assembly; the conveying assembly is positioned at one side of the microscopic scanning assembly; the damping base is arranged on the table top; the micro scanning assembly and the conveying assembly are arranged on the damping base, the damping base is provided with a damping base body, a damping pad is arranged below the damping base body and is provided with a hollow columnar structure, the damping pad is provided with a main shell, one end part of the main shell is provided with a threaded connection part, an upper separation plate and a lower separation plate are arranged inside the main shell, the main shell is divided into a main fluid cavity and a secondary fluid cavity by the upper separation plate and the lower separation plate, the main fluid cavity is located above the secondary fluid cavity, an overflow hole is formed in the upper separation plate and the lower separation plate, a diaphragm is arranged below the lower separation plate, the edge of the diaphragm is fixedly connected with the inner side wall of the main shell, the other end part of the main shell is provided with an anti-skid base, the anti-skid base is provided with a hollow structure, and an auxiliary hole is formed in the side wall of the anti-skid base.
This a supplementary three-dimensional image equipment carries out device that chromosome was unusual detects, through the combination of microscopic scanning subassembly and manipulator subassembly, conveying assembly, realized the incessant scanning of slide glass, realized the degree of automation of equipment to through the setting of shock attenuation base, reduced the mechanical shock that microscopic scanning subassembly receives, also can utilize the shock pad to make the staff obtain the unusual early warning of mechanical structure in time, more guaranteed the stable transmission of slide glass sample and protect experimental sample.
According to the embodiment of the invention, the micro scanning assembly and the conveying assembly are positioned at the same horizontal height, so that stable conveying of the glass slide frame to the objective table is ensured, and a power mechanism in the conveying matrix can transmit vibration to the micro scanning assembly through a joint of the table surface or the objective table and the conveying matrix in the operation process.
More specifically, when the conveying assembly is in a normal working state, namely, the motor and other transmission structures in the internal power mechanism of the conveying assembly normally operate, the amplitude peak value generated by the motor and other transmission structures when mechanical vibration generated by the motor and other transmission structures is transmitted to the shock pad is periodically changed, the buffering gel in the shock pad mainly flows in the main fluid cavity, and little buffering gel enters the auxiliary fluid cavity through the overflow hole, and the elastic diaphragm cannot deform; when the transmission mechanism or the power mechanism of the conveying assembly is abnormal, for example, a motor and a bearing are damaged or the transmission shaft is locally cracked, vibration in the operation process is aggravated, abnormal sound is not generated, so that the abnormal vibration is difficult to be perceived by human ears, the amplitude peak value generated when the mechanical vibration is transmitted to the shock pad exceeds the original range, a large amount of buffer gel in the shock pad flows to the auxiliary fluid cavity through the overflow hole due to the abnormal mechanical vibration, when the diaphragm is insufficient to bear the preset pressure, the diaphragm is cracked, the buffer gel flows into the anti-skid base and then flows out through the auxiliary hole, and therefore, workers can obtain early warning of abnormal mechanical structure, and stable transmission of slide samples and protection of experimental samples are ensured.
The microscopic scanning assembly is provided with a microscopic substrate, an objective lens and an ocular lens are arranged on the microscopic substrate, an objective table is arranged below the objective lens, a positioning boss is arranged on the upper surface of the objective table, a light hole is formed in the lower surface of the objective table, the light hole penetrates through the objective table, a temporary storage bin is arranged on one side of the objective table, and a main controller is arranged on one side of the microscopic scanning assembly and is electrically connected with the microscopic substrate.
According to an embodiment of the present invention, the positioning boss structure is preferably made of a transparent material, and is used for positioning a slide frame placed on the objective table, for example, a CCD positioning device, a grating positioning device, and the like, and the light hole disposed along with the positioning boss and the optical axis can adjust the illumination intensity in the objective lens by the light emitted by the LED lamp, so that the imaging device captures an image with optimal brightness, and the temporary storage bin can be used for temporarily storing the detected slide frame carrying the slide sample, and the image after microscopic scanning is processed by the main controller is transmitted to the imaging device.
The shock-absorbing base is provided with an LED lamp, the LED lamp corresponds to the position of the light hole, the LED lamp is connected with a shading component in a screwed mode, the shading component is of a cylindrical structure, a plurality of light-gathering concave portions are formed in the inner side wall of the shading component at equal intervals in the circumferential direction, and the light-gathering concave portions are of concave structures.
According to the embodiment of the invention, the light shielding component can be used for shielding ambient light to reduce the interference of the ambient light to the LED light source, the light shielding component is coaxially and detachably connected with the optical filter for adjusting the illumination intensity when the illumination intensity is overlarge and influencing imaging of imaging equipment, the LED light can only be guided into approximate parallel light by the components such as a light gathering cover and the like when emitting light, and the light gathering concave part can gather the light scattered to the concave surface of the LED light, so that the illumination intensity is enhanced, more light is ensured to enter the objective lens through the light transmitting hole, the imaging quality is improved, the ambient temperature near the light transmitting hole above the light shielding component is improved through the design of the light gathering concave part, namely, the ambient temperature at the bottom of the light transmitting hole above the light shielding component is reduced through a light gathering mode, and the influence of temperature change on sample observation on the object stage is avoided.
The conveying assembly is provided with a conveying substrate, the conveying substrate is provided with a hollow structure, a power mechanism is arranged in the conveying substrate, a driving wheel and a driven wheel are connected to one side wall of the conveying substrate in a shaft mode, the driving wheel is connected with the driven wheel through belt transmission, one side of the conveying substrate is provided with a side plate, the side plate is perpendicular to the top surface of the conveying substrate, and the side plate can limit a slide frame placed on the conveying substrate.
The device for assisting the three-dimensional image equipment in detecting chromosome abnormality further comprises a manipulator assembly, wherein the manipulator assembly is provided with a manipulator base body, an auxiliary arm is arranged on the manipulator base body, a main manipulator arm and a control arm are hinged to the auxiliary arm, an auxiliary manipulator arm is hinged to the other end of the main manipulator arm in a rotating mode, a sucker is arranged at the end of the auxiliary manipulator arm, and the sucker can suck up a glass slide frame.
According to the embodiment of the invention, the manipulator assembly can adsorb the smooth part on the slide rack through the sucker, so that the slide rack can be taken and placed, and the manipulator assembly can be changed according to different storage positions of the slide rack, for example, the working end of the manipulator is set as the clamping end for the vertically placed slide rack, so that the slide rack is clamped.
The slide glass frame is stored in a slide glass constant temperature cabin, the slide glass constant temperature cabin is provided with a square box body structure, and a plurality of clamping strips are equidistantly distributed on the opposite inner wall surfaces of the slide glass constant temperature cabin.
According to one embodiment of the invention, the prepared slide sample needs to be ensured to have proper temperature in the long-time preservation process, and the slide constant temperature cabin ensures observability of the sample.
The device for assisting the three-dimensional image equipment in detecting the chromosome abnormality further comprises the imaging equipment, wherein the imaging equipment is provided with a display and a host, and the imaging equipment is electrically connected with the host controller.
Compared with the prior art, the invention has the beneficial effects that:
1. according to the device for assisting the three-dimensional image equipment in detecting the chromosome abnormality, the vibration transmitted by the conveying substrate to the microscopic scanning assembly through the table surface is effectively reduced through the arrangement of the damping base;
2. according to the device for assisting the three-dimensional image equipment in detecting the chromosome abnormality, through the arrangement of the membrane, workers can be timely warned of the mechanical structure abnormality, and stable transmission of a glass slide sample and protection of an experimental sample are further ensured;
3. this a supplementary three-dimensional image equipment carries out device that chromosome was unusual detects, through the setting of shading part, can strengthen illumination intensity, guarantees that more light enters into objective through the light trap, has improved imaging quality.
Drawings
FIG. 1 is a schematic structural diagram of a preferred embodiment of an apparatus for assisting a three-dimensional image device in detecting chromosomal abnormalities according to the present invention;
FIG. 2 is a schematic view of the structure of the microscanning assembly, the conveying assembly, and the shock-absorbing base shown in FIG. 1;
FIG. 3 is another azimuthal view of FIG. 2;
FIG. 4 is a schematic view of the manipulator assembly of FIG. 1;
FIG. 5 is a schematic view of the structure of the slide constant temperature chamber;
FIG. 6 is a schematic view of the structure of the slide holder of FIG. 2;
FIG. 7 is a schematic view illustrating an inner structure of the shock pad shown in FIG. 2;
fig. 8 is a schematic view of the structure of the light shielding member shown in fig. 2.
In the figure: 1. a microscanning assembly; 11. a microscope base; 111. an objective lens; 112. an eyepiece; 12. an objective table; 121. positioning the boss; 122. a light hole; 13. temporary storage bin; 14. a main controller; 15. a table top; 16. an LED lamp; 17. a light shielding member; 171. a light-condensing concave portion; 2. a transport assembly; 21. conveying the substrate; 22. a driving wheel; 23. driven wheel; 24. a belt; 25. a side plate; 26. a slide holder; 3. a shock absorbing base; 31. a shock absorbing matrix; 32. a shock pad; 321. a main housing; 322. a screw connection part; 323. a main fluid chamber; 324. a secondary fluid chamber; 325. an upper partition plate; 326. a bottom separation plate; 327. an overflow hole; 328. a membrane; 329. an anti-slip base; 329a, auxiliary holes; 4. a manipulator assembly; 41. a manipulator base; 42. an auxiliary arm; 43. a main mechanical arm; 44. a control arm; 45. an auxiliary mechanical arm; 46. a suction cup; 5. a glass slide constant temperature cabin; 51. a clamping strip; 6. an image forming apparatus; 61. a display; 62. and a host.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Referring to fig. 1-3 and 7, an embodiment of the present invention is provided: an apparatus for assisting a three-dimensional image device in chromosome abnormality detection, comprising a microscanning assembly 1; a conveying component 2, wherein the conveying component 2 is positioned at one side of the microscopic scanning component 1; the damping base 3, the damping base 3 locates on mesa 15; the microscan subassembly 1 and the conveying subassembly 2 are arranged on the shock absorber base 3, the shock absorber base 3 is provided with a shock absorber 31, a shock absorber 32 is arranged below the shock absorber 31, the shock absorber 32 is provided with a hollow columnar structure, the shock absorber 32 is provided with a main shell 321, one end part of the main shell 321 is provided with a screw connection part 322, an upper separation plate 325 and a lower separation plate 326 are arranged in the main shell 321, the main shell 321 is divided into a main fluid cavity 323 and a secondary fluid cavity 324 by the upper separation plate 325 and the lower separation plate 326, the main fluid cavity 323 is arranged above the secondary fluid cavity 324, the upper separation plate 325 and the lower separation plate 326 are provided with overflow holes 327, a diaphragm 328 is arranged below the lower separation plate 326, the edge of the diaphragm 328 is fixedly connected with the inner side wall of the main shell 321, the other end part of the main shell 321 is provided with an anti-slip base 329, the anti-slip base 329 is provided with a hollow structure, and auxiliary holes 329a are arranged on the side wall of the anti-slip base 329.
This device that supplementary three-dimensional image equipment carries out unusual detection of chromosome, through the combination of microscanning subassembly 1 and manipulator subassembly 4, conveying component 2, realized the uninterrupted scanning of slide glass, realized the degree of automation of equipment to through the setting of shock attenuation base 3, reduced the mechanical shock that microscanning subassembly 1 receives, also can utilize shock pad 32 to make the staff in time obtain the unusual early warning of mechanical structure, more guaranteed the stable transmission of slide glass sample and protect experimental sample.
Since the microscan component 1 and the conveying component 2 are at the same level to ensure stable conveying of the slide frame 26 to the objective table 12, and the power mechanism in the conveying matrix 21 can transfer vibration to the microscan component 1 through the connection of the table 15 or the objective table 12 and the conveying matrix 21 in the operation process, the vibration transferred to the microscan component 1 by the conveying matrix 21 through the table 15 is effectively reduced through the arrangement of the damping base 3, in particular, semi-fluid buffer gel is filled in the main fluid cavity 323 in the damping pad 32 arranged below the damping matrix 31, when the vibration is transferred to the damping pad 32, the damping pad 32 firstly consumes vibration energy through the elastic structure of the main shell 321, then the filled buffer gel is extruded to generate certain flow, and the purpose of consuming most of vibration energy is achieved, wherein the diaphragm 328 can accumulate with the downward of the buffer gel preferentially and deform accordingly to a certain extent.
More specifically, when the conveying assembly 2 is in a normal working state, that is, the motor and other transmission structures in the internal power mechanism of the conveying assembly are normally operated, the amplitude peak value generated by the motor and other transmission structures when the mechanical vibration generated by the motor and other transmission structures is transmitted to the shock pad 32 is periodically changed, the buffering gel in the shock pad 32 mainly flows in the main fluid cavity 323, and rarely enters the auxiliary fluid cavity 324 through the overflow holes 327, and the elastic diaphragm 328 is not deformed; when the transmission mechanism or the power mechanism of the conveying assembly 2 is abnormal, for example, the motor and the bearing are damaged or the transmission shaft is partially cracked, so that vibration in the operation process is aggravated, abnormal sound is not generated, and is difficult to be perceived by human ears, and the amplitude peak value generated when the mechanical vibration generated by the motor and the bearing is transmitted to the shock pad 32 exceeds the original range, a large amount of buffer gel in the shock pad 32 flows to the auxiliary fluid cavity 324 through the overflow hole 327 due to the abnormal mechanical vibration, and when the diaphragm 328 is insufficient to bear the preset pressure, the buffer gel breaks by itself, flows into the anti-skid base 329 and flows out through the auxiliary hole 329a, so that staff is warned of abnormal mechanical structure, and stable transmission of a slide glass sample and protection of an experimental sample are further ensured.
Referring to fig. 1-3, a micro-scanning assembly 1 has a microscope base 11, an objective 111 and an eyepiece 112 are provided on the microscope base 11, an objective table 12 is provided under the objective 111, a positioning boss 121 is provided on an upper surface of the objective table 12, a light hole 122 is provided on a lower surface of the objective table 12, the light hole 122 penetrates the objective table 12, a temporary storage bin 13 is provided on one side of the objective table 12, a main controller 14 is provided on one side of the micro-scanning assembly 1, and the main controller 14 is electrically connected with the microscope base 11.
The positioning boss 121 is preferably made of transparent material, and is used for positioning the slide frame 26 placed on the stage 12, for example, CCD positioning, grating positioning, etc., and the light hole 122 disposed along with the optical axis of the positioning boss 121 can adjust the illumination intensity in the objective 111 by transmitting the light emitted by the LED lamp 16, so that the imaging device 6 captures an image with optimal brightness, and the temporary storage bin 13 can be used for temporarily storing the detected slide frame 26 carrying the slide sample, and the image after being processed by the main controller 14 through microscopic scanning is transmitted to the imaging device 6.
Referring to fig. 1-3 and 8, the shock absorbing base 3 is provided with an LED lamp 16, the LED lamp 16 corresponds to the light hole 122, the LED lamp 16 is screwed with a light shielding member 17, the light shielding member 17 has a cylindrical structure, a plurality of light focusing concave portions 171 are circumferentially equidistantly arranged on the inner side wall of the light shielding member 17, and the light focusing concave portions 171 have a concave structure.
The shading component 17 not only can be used for shading ambient light to reduce its interference to the LED lamp 16 light source, and coaxial detachably is connected with the light filter on the shading component 17, be used for when illumination intensity is too big, adjust illumination intensity when influencing imaging device 6 formation of image, and LED lamp 16 can only be guided into approximate parallel light by parts such as snoot when the light, spotlight concave part 171 then can assemble the light that diverges to its concave surface department, thereby reinforcing illumination intensity, it enters into objective 111 to guarantee more light through light trap 122, imaging quality has been improved, also through spotlight concave part 171's design, the ambient temperature near light trap 122 above the shading component 17 has been improved, namely reduce light trap 122 bottom ambient temperature above the shading component 17 through spotlight mode, avoid its temperature variation to influence the sample observation on objective table 12.
Referring to fig. 1-4, a conveying assembly 2 has a conveying base 21, the conveying base 21 has a hollow structure, a power mechanism is arranged in the conveying base 21, a driving wheel 22 and a driven wheel 23 are connected to one side wall of the conveying base 21 in a shaft manner, the driving wheel 22 and the driven wheel 23 are connected in a transmission manner through a belt 24, a side plate 25 is arranged on one side of the conveying base 21, the side plate 25 is perpendicular to the top surface of the conveying base 21, and the side plate 25 can limit a slide frame 26 placed on the conveying base 21.
The device for assisting the three-dimensional image equipment in detecting chromosome abnormality further comprises a manipulator assembly 4, wherein the manipulator assembly 4 is provided with a manipulator base 41, an auxiliary arm 42 is arranged on the manipulator base 41, a main manipulator 43 and a control arm 44 are hinged on the auxiliary arm 42, a secondary manipulator 45 is hinged at the other end part of the main manipulator 43 in a rotating way, a sucker 46 is arranged at the end part of the secondary manipulator 45, and the sucker 46 can suck the slide frame 26.
The manipulator assembly 4 can adsorb the smooth part on the slide frame 26 through the sucking disc 46, so that the slide frame 26 can be taken and placed, and the manipulator assembly 4 can be changed according to different storage positions of the slide frame 26, for example, the working end of the manipulator is set to be a clamping end for the vertically placed slide frame 26, so that the slide frame 26 is clamped.
Referring to fig. 5, the slide holder 26 is stored in the slide constant temperature chamber 5, the slide constant temperature chamber 5 has a square box structure, and a plurality of clamping strips 51 are equidistantly arranged on opposite inner wall surfaces of the slide constant temperature chamber 5.
The prepared slide sample needs to ensure proper temperature in the long-time preservation process, and the slide constant temperature cabin 5 ensures observability of the sample.
Referring to fig. 1, the apparatus for assisting a three-dimensional image device in detecting a chromosome abnormality further includes an imaging device 6, the imaging device 6 has a display 61 and a host 62, and the imaging device 6 is electrically connected to the host controller 14.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Claims (7)
1. An apparatus for assisting a three-dimensional image device in chromosome abnormality detection, comprising,
a microscanning assembly (1);
a conveying assembly (2), wherein the conveying assembly (2) is positioned at one side of the microscopic scanning assembly (1);
the damping base (3), the said damping base (3) locates on mesa (15);
the method is characterized in that: the micro scanning assembly (1) and the conveying assembly (2) are arranged on the damping base (3), the damping base (3) is provided with a damping base body (31), a damping pad (32) is arranged below the damping base body (31), the damping pad (32) is provided with a hollow columnar structure, the damping pad (32) is provided with a main shell (321), one end part of the main shell (321) is provided with a threaded connection part (322), an upper separation plate (325) and a lower separation plate (326) are arranged inside the main shell (321), the inside of the main shell (321) is separated into a main fluid cavity (323) and a secondary fluid cavity (324) by the upper separation plate (325) and the lower separation plate (326), the main fluid cavity (323) is located above the secondary fluid cavity (324), the upper separation plate (325) and the lower separation plate (326) are provided with a through hole (327), and the lower separation plate (326) is provided with a membrane (328), and the edge of the membrane (328) is fixedly connected with the inner side wall of the main shell (321). An anti-slip base (329) is arranged at the other end part of the main shell (321), the anti-slip base (329) is of a hollow structure, and an auxiliary hole (329 a) is formed in the side wall of the anti-slip base (329); the main fluid cavity (323) in the damping pad (32) arranged below the damping matrix (31) is filled with semi-fluid buffer gel, when vibration is transmitted to the damping pad (32), the damping pad (32) firstly consumes vibration energy through the elastic structure of the main shell (321) of the damping pad, then the vibration energy is consumed by extruding the filled buffer gel in the damping pad to enable the damping pad to flow, the diaphragm (328) is made of elastic materials, the damping pad can be broken when bearing the pressure exceeding the preset pressure, and the buffer gel flows out through the auxiliary holes (329 a) after flowing into the anti-skid base (329) for early warning;
the microscopic scanning assembly (1) is provided with a microscopic substrate (11), an objective lens (111) and an eyepiece (112) are arranged on the microscopic substrate (11), an objective table (12) is arranged below the objective lens (111), a positioning boss (121) is arranged on the upper surface of the objective table (12), a light hole (122) is formed in the lower surface of the objective table (12), and the light hole (122) penetrates through the objective table (12);
be equipped with LED lamp (16) on shock attenuation base (3), LED lamp (16) with the position of light trap (122) is corresponding, the spiro union has shading part (17) on LED lamp (16), shading part (17) have cylindric structure, circumference equidistance is equipped with a plurality of spotlight concave part (171) on the inside wall of shading part (17), spotlight concave part (171) have concave surface structure.
2. The apparatus for assisting a three-dimensional imaging device in detecting chromosomal abnormalities according to claim 1, characterized in that: one side of the objective table (12) is provided with a temporary storage bin (13).
3. The apparatus for assisting a three-dimensional imaging device in detecting chromosomal abnormalities according to claim 2, characterized in that: one side of the micro scanning assembly (1) is provided with a main controller (14), and the main controller (14) is electrically connected with the microscope base body (11).
4. The apparatus for assisting a three-dimensional imaging device in detecting chromosomal abnormalities according to claim 1, characterized in that: the conveying assembly (2) is provided with a conveying base body (21), the conveying base body (21) is of a hollow structure, a power mechanism is arranged inside the conveying base body (21), a driving wheel (22) and a driven wheel (23) are connected to one side wall of the conveying base body (21) in a shaft mode, the driving wheel (22) and the driven wheel (23) are connected through a belt (24) in a transmission mode, one side of the conveying base body (21) is provided with a side plate (25), the side plate (25) is perpendicular to the top surface of the conveying base body (21), and the side plate (25) can limit a glass slide frame (26) placed on the conveying base body (21).
5. An apparatus for assisting a three-dimensional image device in detecting chromosomal abnormalities as set forth in claim 4 comprising, a manipulator assembly (4), characterized in that: the manipulator assembly (4) is provided with a manipulator base body (41), an auxiliary arm (42) is arranged on the manipulator base body (41), a main manipulator arm (43) and a control arm (44) are hinged to the auxiliary arm (42), a secondary manipulator arm (45) is hinged to the other end portion of the main manipulator arm (43) in a rotating mode, a sucker (46) is arranged at the end portion of the secondary manipulator arm (45), and the sucker (46) can suck the glass slide frame (26).
6. The apparatus for assisting a three-dimensional imaging device in detecting chromosomal abnormalities according to claim 5, characterized in that: the glass slide frame (26) is stored in the glass slide constant temperature cabin (5), the glass slide constant temperature cabin (5) is provided with a square box body structure, and a plurality of clamping strips (51) are equidistantly distributed on the opposite inner wall surfaces of the glass slide constant temperature cabin (5).
7. An apparatus for assisting a three-dimensional imaging device in chromosome abnormality detection according to claim 3, comprising an imaging device (6), characterized in that: the imaging device (6) is provided with a display (61) and a host (62), and the imaging device (6) is electrically connected with the main controller (14).
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| CN202310047385.6A CN116297444B (en) | 2023-01-31 | 2023-01-31 | Device for assisting three-dimensional image equipment in chromosome abnormality detection |
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