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CN116271442A - A kind of plastic hydrophilic guide wire and its core wire preparation method - Google Patents

A kind of plastic hydrophilic guide wire and its core wire preparation method Download PDF

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Publication number
CN116271442A
CN116271442A CN202310310565.9A CN202310310565A CN116271442A CN 116271442 A CN116271442 A CN 116271442A CN 202310310565 A CN202310310565 A CN 202310310565A CN 116271442 A CN116271442 A CN 116271442A
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plastic
core wire
hydrophilic
coating layer
based polymer
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陈旭东
李明
许佳润
王文刚
王富玉
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Shenzhen Liankehanwei Medical Technology Co ltd
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Shenzhen Liankehanwei Medical Technology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09Guide wires
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04Macromolecular materials
    • A61L31/048Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08Materials for coatings
    • A61L31/10Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29DPRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D99/00Subject matter not provided for in other groups of this subclass
    • B29D99/0078Producing filamentary materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/18Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00Materials or methods for coatings medical devices
    • A61L2420/08Coatings comprising two or more layers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09Guide wires
    • A61M2025/09108Methods for making a guide wire
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09Guide wires
    • A61M2025/09133Guide wires having specific material compositions or coatings; Materials with specific mechanical behaviours, e.g. stiffness, strength to transmit torque
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/02General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0238General characteristics of the apparatus characterised by a particular materials the material being a coating or protective layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00Methods of manufacture, assembly or production
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A30/00Adapting or protecting infrastructure or their operation
    • Y02A30/14Extreme weather resilient electric power supply systems, e.g. strengthening power lines or underground power cables

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Media Introduction/Drainage Providing Device (AREA)
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Abstract

The invention discloses a plastic hydrophilic guide wire and a preparation method of the plastic hydrophilic guide wire core wire, comprising a plastic core wire, a water-based polymer coating layer coated outside the plastic core wire and a cylindrical elastic piece arranged between the plastic core wire and the water-based polymer coating layer; a hydrophilic coating is arranged on the surface of the water-based polymer coating layer; the hydrophilic coating is sprayed on the water-based polymer coating layer through a plasma spraying process; a method for preparing a core wire, comprising the steps of: step S1, mixing plastic raw material powder; s2, filling the mixed powder in the step S1 into a die cavity and pressing the powder into a blank; step S3, adding glue into the blank pressed in the step S2 according to a proportion; s4, placing the blank prepared in the step S3 into a high-temperature furnace for powder metallurgy synthesis, wherein the high-temperature furnace is vacuum or is filled with protective atmosphere; the core wire material is not limited to the metal material any more, and the strength of the core wire is stronger; the plastic is used as the raw material for manufacturing the core wire, so that the cost is saved, the preparation process is simple, and the flow is short; and is easier to shape.

Description

一种塑料亲水导丝及其芯丝制备方法A kind of plastic hydrophilic guide wire and its core wire preparation method

技术领域technical field

本发明涉及导丝技术领域,尤其涉及一种塑料亲水导丝及其芯丝制备方法。The invention relates to the technical field of guide wires, in particular to a plastic hydrophilic guide wire and a method for preparing a core wire thereof.

背景技术Background technique

介入治疗是利用现代高科技手段进行的一种微创性治疗--就是在医学影像设备的引导下,将特制的导管、导丝等精密器械引入人体,对体内病态进行诊断和局部治疗;现有的塑料芯丝丝的制作材料主要是金属材料整体制成,这样会消耗大量的金属。Interventional therapy is a kind of minimally invasive treatment using modern high-tech means—that is, under the guidance of medical imaging equipment, special catheters, guide wires and other precision instruments are introduced into the human body to diagnose and locally treat pathological conditions in the body; Some plastic core wires are mainly made of metal materials as a whole, which consumes a lot of metal.

发明内容Contents of the invention

本发明的目的是为了解决现有技术中存在的缺点,而提出的一种塑料亲水导丝及其芯丝制备方法。The object of the present invention is to solve the shortcomings in the prior art, and propose a plastic hydrophilic guide wire and a method for preparing the core wire thereof.

为了实现上述目的,本发明采用了如下技术方案:In order to achieve the above object, the present invention adopts the following technical solutions:

一种塑料亲水导丝,包括塑料芯丝、包覆于所述塑料芯丝外部的水性聚合物包覆层,以及设于所述塑料芯丝与所述水性聚合物包覆层之间的筒状弹性件;所述水性聚合物包覆层表面设有亲水涂层;所述亲水涂层通过等离子喷涂工艺喷涂于所述水性聚合物包覆层上。A plastic hydrophilic guide wire, comprising a plastic core wire, a water-based polymer cladding layer coated on the outside of the plastic core wire, and a water-based polymer cladding layer arranged between the plastic core wire and the water-based polymer cladding layer A cylindrical elastic member; the surface of the water-based polymer coating layer is provided with a hydrophilic coating; the hydrophilic coating is sprayed on the water-based polymer coating layer by a plasma spraying process.

优选的,所述水性聚合物包覆层包括聚氨酯包覆层、尼龙包覆层、嵌段聚醚酰胺弹性体包覆层。Preferably, the water-based polymer coating layer includes a polyurethane coating layer, a nylon coating layer, and a block polyetheramide elastomer coating layer.

优选的,所述亲水涂层包括改性亲水型PTFE亲水涂层。Preferably, the hydrophilic coating includes a modified hydrophilic PTFE hydrophilic coating.

优选的,一种芯丝制备方法,包括以下步骤:Preferably, a method for preparing a core wire, comprising the following steps:

步骤S1,塑料原料粉末混合;Step S1, mixing plastic raw material powder;

步骤S2,将步骤S1中混好的粉末装入模腔中压制成坯;In step S2, the powder mixed in step S1 is packed into a mold cavity and pressed into a billet;

步骤S3,将步骤S2中压制好的坯料按比例加入胶水;Step S3, adding glue in proportion to the blank pressed in step S2;

步骤S4,将步骤S3中制得的坯料放入高温炉内粉末冶金合成,高温炉为真空或通入保护性气氛。Step S4, put the billet prepared in step S3 into a high-temperature furnace for powder metallurgy synthesis, and the high-temperature furnace is vacuum or filled with a protective atmosphere.

优选的,所述步骤S2中,所述压制所施压力大小的范围为10MPa~80MPa。Preferably, in the step S2, the pressure applied for the pressing ranges from 10 MPa to 80 MPa.

优选的,所述步骤S3中,所述坯料与所述胶水比例为2∶1。Preferably, in the step S3, the ratio of the blank to the glue is 2:1.

优选的,所述塑料为PV材质、PVC材质或聚乙烯材质。Preferably, the plastic is made of PV, PVC or polyethylene.

与现有技术相比,本发明的有益效果是:Compared with prior art, the beneficial effect of the present invention is:

本发明设计一种塑料亲水导丝及其芯丝制备方法,芯丝材质不再局限于金属材质,芯丝强度更强;通过塑料作为芯丝制作原料更加节省成本,并且制备工艺简单,流程短;更容易塑形。The present invention designs a plastic hydrophilic guide wire and its core wire preparation method. The material of the core wire is no longer limited to metal material, and the strength of the core wire is stronger; the use of plastic as the raw material for the core wire is more cost-effective, and the preparation process is simple and the process flow is simple. Short; easier to shape.

附图说明Description of drawings

图1为本发明提出的结构示意图;Fig. 1 is the structural representation that the present invention proposes;

图2为本发明提出的芯丝制备方法流程示意图。Fig. 2 is a schematic flow chart of the core filament preparation method proposed by the present invention.

图例说明:illustration:

1、塑料芯丝,2、水性聚合物包覆层,3、亲水涂层。1. Plastic core wire, 2. Water-based polymer coating, 3. Hydrophilic coating.

具体实施方式Detailed ways

下面将结合本发明实施例中的附图,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

在本发明的描述中,需要说明的是,术语“中心”、“上”、“下”、“左”、“右”、“竖直”、“水平”、“内”、“外”等指示的方位或位置关系为基于附图所示的方位或位置关系,仅是为了便于描述本发明和简化描述,而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作,因此不能理解为对本发明的限制;术语“第一”、“第二”、“第三”仅用于描述目的,而不能理解为指示或暗示相对重要性;此外,除非另有明确的规定和限定,术语“安装”、“相连”、“连接”应做广义理解,例如,可以是固定连接,也可以是可拆卸连接,或一体地连接;可以是机械连接,也可以是电连接;可以是直接相连,也可以通过中间媒介间接相连,可以是两个元件内部的连通。对于本领域的普通技术人员而言,可以具体情况理解上述术语在本发明中的具体含义。In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer" etc. The indicated orientation or positional relationship is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the referred device or element must have a specific orientation, or in a specific orientation. construction and operation, and therefore cannot be construed as limiting the present invention; the terms "first", "second", and "third" are used for descriptive purposes only, and cannot be construed as indicating or implying relative importance; in addition, unless otherwise Clearly stipulated and limited, the terms "installation", "connection" and "connection" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or a Electrical connection; it can be directly connected or indirectly connected through an intermediary, and it can be the internal communication of two components. Those of ordinary skill in the art can understand the specific meanings of the above terms in the present invention in specific situations.

参照图1至图2所示,一种塑料亲水导丝,包括塑料芯丝、包覆于塑料芯丝外部的水性聚合物包覆层,以及设于塑料芯丝与水性聚合物包覆层之间的筒状弹性件;水性聚合物包覆层表面设有亲水涂层;亲水涂层通过等离子喷涂工艺喷涂于水性聚合物包覆层上。Referring to Figures 1 to 2, a plastic hydrophilic guide wire includes a plastic core wire, a water-based polymer coating coated on the outside of the plastic core wire, and a plastic core wire and a water-based polymer coating. The cylindrical elastic part in between; the surface of the water-based polymer coating layer is provided with a hydrophilic coating; the hydrophilic coating is sprayed on the water-based polymer coating layer by a plasma spraying process.

其中,水性聚合物包覆层包括聚氨酯包覆层、尼龙包覆层、嵌段聚醚酰胺弹性体包覆层。Wherein, the water-based polymer coating layer includes a polyurethane coating layer, a nylon coating layer, and a block polyetheramide elastomer coating layer.

亲水涂层包括改性亲水型PTFE亲水涂层。The hydrophilic coating includes a modified hydrophilic PTFE hydrophilic coating.

一种芯丝制备方法,包括以下步骤:A method for preparing a core wire, comprising the steps of:

步骤S1,塑料原料粉末混合;Step S1, mixing plastic raw material powder;

步骤S2,将步骤S1中混好的粉末装入模腔中压制成坯;In step S2, the powder mixed in step S1 is packed into a mold cavity and pressed into a billet;

步骤S3,将步骤S2中压制好的坯料按比例加入胶水;Step S3, adding glue in proportion to the blank pressed in step S2;

步骤S4,将步骤S3中制得的坯料放入高温炉内粉末冶金合成,高温炉为真空或通入保护性气氛。Step S4, put the billet prepared in step S3 into a high-temperature furnace for powder metallurgy synthesis, and the high-temperature furnace is vacuum or filled with a protective atmosphere.

步骤S2中,压制所施压力大小的范围为10MPa~80MPa;如10MPa、15MPa、20MPa、25MPa、30MPa、35MPa、40MPa、45MPa、50MPa、55MPa、60MPa、65MPa、70MPa、75MPa、或80MPa等;步骤S3中,坯料与胶水比例为2∶1;步骤S4中高温炉加热温度为850℃,保温时间4小时,真空度10-3Pa;塑料为PV材质、PVC材质或聚乙烯材质。In step S2, the range of pressure applied for pressing is 10MPa-80MPa; such as 10MPa, 15MPa, 20MPa, 25MPa, 30MPa, 35MPa, 40MPa, 45MPa, 50MPa, 55MPa, 60MPa, 65MPa, 70MPa, 75MPa, or 80MPa; step In S3, the ratio of blank to glue is 2:1; in step S4, the heating temperature of the high-temperature furnace is 850°C, the holding time is 4 hours, and the vacuum degree is 10-3Pa; the plastic is made of PV, PVC or polyethylene.

以上,仅为本发明较佳的具体实施方式,但本发明的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,根据本发明的技术方案及其发明构思加以等同替换或改变,都应涵盖在本发明的保护范围之内。The above is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Anyone familiar with the technical field within the technical scope disclosed in the present invention, according to the technical solutions of the present invention and its Any equivalent replacement or change of the inventive concept shall fall within the protection scope of the present invention.

Claims (7)

1. The hydrophilic plastic guide wire is characterized by comprising a plastic core wire, a water-based polymer coating layer coated outside the plastic core wire and a cylindrical elastic piece arranged between the plastic core wire and the water-based polymer coating layer; the surface of the water-based polymer coating layer is provided with a hydrophilic coating; the hydrophilic coating is sprayed on the aqueous polymer coating layer through a plasma spraying process.
2. The plastic hydrophilic guidewire of claim 1, wherein the aqueous polymer coating comprises a polyurethane coating, a nylon coating, a block polyether amide elastomer coating.
3. The plastic hydrophilic guidewire of claim 1, wherein the hydrophilic coating comprises a modified hydrophilic PTFE hydrophilic coating.
4. The preparation method of the core wire is characterized by comprising the following steps of:
step S1, mixing plastic raw material powder;
s2, filling the mixed powder in the step S1 into a die cavity and pressing the powder into a blank;
step S3, adding glue into the blank pressed in the step S2 according to a proportion;
and S4, placing the blank prepared in the step S3 into a high-temperature furnace for powder metallurgy synthesis, wherein the high-temperature furnace is vacuum or is filled with protective atmosphere.
5. The method according to claim 4, wherein in the step S2, the pressing force is in a range of 10MPa to 80MPa.
6. The method according to claim 4, wherein in the step S3, the ratio of the blank to the glue is 2:1.
7. The method of claim 4, wherein the plastic is a PV material, a PVC material, or a polyethylene material.
CN202310310565.9A 2023-03-28 2023-03-28 A kind of plastic hydrophilic guide wire and its core wire preparation method Pending CN116271442A (en)

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