CN1162665A - Chitin medical fiber paper and its manufacturing method - Google Patents

Abstract

The invention relates to a method for manufacturing medical chitin fiber, and a chitin fiber paper type wound healing tape, a wound patch, other wound dressings and bandages prepared from the fiber. The method is characterized in that: the chitin concentration is 1-10%, the chitin, LICL and DMAc are mixed according to the weight ratio of 1: 1-6: 100-800, the coagulating bath DMAc and ethanol are mixed according to the weight ratio of 10-500: 90-50, and the coagulated fibre is properly stretched, and its stretching ratio is 0.5-3 times, and cleaned by using detergent ethyl alcohol fibre. Has the advantages of good adhesive property, multi-layer application, good air permeability, convenient carrying and the like.

Description

Chitin medical fiber paper and its manufacturing method

The invention relates to a manufacturing method of medical chitin fiber and chitin fiber paper wound patch and wound dressing prepared from the fiber.

At present, traditional cotton gauze dressings, which are widely used by surgical patients in medicine, can easily cause skin inflammation during use. Sexual dressing changes not only increase the pain of the patient, but also cause new wounds to the healing wound, resulting in slow wound healing and large scars. Therefore, it is the direction of the present medical circle to seek the medical dressing with better use effect.

Chitin is a kind of positively charged natural polysaccharide polymer widely present in crabs, crabs, insect shells, fungi, and algae cell walls. In nature, the storage capacity of chitin is second only to cellulose, and it is a natural resource with great potential practical value and yet to be developed. The chemical name of chitin is polyacetylglucosamine, its chemical structure is similar to that of natural cellulose, chitin is non-toxic to human body, has no irritation and allergic reaction, has good biocompatibility with human body, has no antibody reaction, and can It is decomposed by lysozyme in the human body and absorbed by the human body. It also has unique medicinal properties such as anti-inflammatory, hemostatic, analgesic and promotion of human tissue growth.

At present, the solvents used in the manufacture of chitin spinning slurry in various countries in the world include a mixture of trichloroacetic acid and chlorinated hydrocarbons, a mixture of dichloroacetic acid and chlorinated hydrocarbons, a mixed solvent of dimethylacetamide (DM Ac) and lithium chloride, Mixed solvents of N-methylpyrrolidone (NMP) and lithium chloride, etc.; in the published literature, the first two solvents are used more.

Japanese Patent Publication No. 57-16999 patent proposes a manufacturing method of chitin fiber paper, the mixture of chitin and formic acid is repeatedly frozen and thawed, then dichloroacetic acid is added to prepare a uniform spinning slurry, and the slurry is extruded In the first coagulation bath of ethyl acetate, through the second coagulation bath of methanol, and finally washed with ethanol. The monofilament fineness of the obtained fiber is 3.0 bags (ie 3.3dte×), and the strength is 1.0g/d (ie 0.89CM/DTE×). Cut the fiber into about 5mm long, and make paper according to the usual papermaking process. The weight of the obtained paper is 65g/m, and the burst resistance factor is 1.11.

The purpose of the present invention is to propose a process using DMAC-LICL or NMP-LICL as a solvent, wet spinning and proper stretching to produce chitin fibers that meet the requirements for processing medical paper. The fineness of the fiber is 0.56-11.1dte×(0.5-10d), the dry strength is 1.34-1.78CM/dte×(1.5-2.0g/d), and the elongation is 4-8%. It is enough to make paper with this fiber Development of multi-purpose medical chitin fiber paper dressing. Chitin prepared with DMAc-LICL or NMP-LICL has the advantages of low corrosion to equipment and excellent stability of the slurry. The prepared slurry can still be spun normally after being placed for more than one year.

The chitin referred to in the present invention also includes deacetylated chitin (also known as chitosan, chitosan), which is a commercially available product extracted and prepared from crab shells. Moreover, the main quality indicators of raw chitin, such as color, moisture, ash, viscosity, solubility, etc., are closely related to the preparation of chitin slurry, the spinning of fibers and the quality of finished fibers. The requirement of raw material chitin quality index is water content≤10%, ash content≤0.3%, inherent viscosity is at 4.5-5.5, and requires its good solubility; Chitin concentration (also Called slurry concentration) is generally 1-10%, more ideal concentration is 1-6%.

The process that the present invention makes chitin fiber paper is as follows:

Using DMAc-LICL or NMP-LICL as a solvent, stirring and dissolving at room temperature or lower than room temperature for a certain period of time, the chitin spinning slurry is prepared. After the slurry is filtered and vacuum defoamed, it is transported to the spinning cap by a metering pump, and the spinning slurry is extruded from the cap hole into the coagulation bath to be solidified into fibers. The specification of the spinning cap used is 40-120 holes, the hole diameter is 0.04-0.08mm, and the coagulant of the coagulation bath can be preferably acetone, methanol, ethanol, etc. The concentration of the coagulant in the coagulation bath is adjusted depending on the number of spinning holes, the size of the spinning speed and other factors. Generally, the concentration of the coagulation bath is controlled at more than 50%, and the temperature is 100-300°C. In order to ensure that the fiber has sufficient strength, it must be properly stretched during the spinning process, and the stretching ratio can be selected between 0.5 and 2 times. The coagulated fibers must be thoroughly washed. The best detergent is absolute ethanol. The washed chitin fibers are directly cut into short fibers with a length of 5mm, dispersed evenly in water, and made into paper according to the conventional papermaking process. According to the needs of the product, it can be made into medical paper of different weights and different sizes.

As the raw material of medical fiber paper, the chitin fiber must be controlled within a certain range in diameter and length. If the fiber is too thick, the self-adhesiveness between the fibers will decrease during papermaking; if the fiber is too long, the dispersion in water will be poor, which is not conducive to papermaking. Paper, so the fineness of the fiber should be controlled below 11.1dte×, and the fiber length should not exceed 20mm.

The actual process that the present invention makes chitin fiber paper is as follows:

Put 3 parts of chitin powder (DMAc) with a viscosity of 1pas into a DMAc mixed solvent containing 6% LICL, and stir for three hours at 20°C to prepare a transparent chitin spinning slurry. These slurries were filtered through a 300-mesh stainless steel mesh under a pressure of 0.4 MPa, and then degassed under vacuum. The chitin slurry after filtering and defoaming is passed through the metering pump with a pressure of 0.2Mpa. The specification of the spinning cap is 100 holes, and the aperture is 0.8mm. Spinning is carried out, the spinning speed is controlled at about 15m/min, the coagulation bath adopts DMAc mixed solution containing 70% absolute ethanol, and the chitin fiber taken out of the coagulation bath is continued to be washed with absolute ethanol and properly stretched , the stretching ratio is controlled between 0.5-2 times, the chitin fiber monofilament fineness after washing is 2.5dtex, the dry strength is 1.5cN/dtex, and the elongation at break is 7-8%. The chitin fibers are bundled and cut into short fibers of 5 mm in length, dispersed evenly in water, and chitin fiber paper is made by conventional papermaking methods. Then cut into various papers of different specifications according to the required size, and paste them on the elastic non-woven fabric substrate coated with self-adhesive to make various wound healing patches and small-sized wound patches or different specifications After the medical or household wound dressing is applied, it is packed into a prepared packaging bag under the guarantee of N environment, and then the finished product is finished by routine disinfection.

Compared with natural polymers such as cotton fibers and various synthetic polymeric medical dressings, the chitin fiber paper-type wound dressing made by the above method has the following characteristics:

1. Good applicability, can be applied directly on the wound surface, can be used to cover the wound surface, has anti-inflammatory, hemostasis, pain relief, and promotes the growth of wound tissue on the wound surface, can promote wound healing, and even make scars disappear.

2. There is no need to change the dressing during the treatment, and it can also be applied repeatedly in multiple layers to reduce the pain of the patient.

3. Good air permeability, good moisture permeability, no fluid accumulation under the dressing, keep the wound surface dry, and the wound heals quickly.

4. It has significant curative effect on burns, scalds, body surface ulcers, etc. It can be used as a patch after surgery and plastic surgery in various hospitals; it can also be used for field rescue, and it can also be used as a standing medicine for family and travel.

5. It can be sterilized by conventional methods, and it is very convenient to use and carry.

Claims (2)

1, a kind of manufacture method of chitin medical fiber paper is characterized in that: chitin concentration is 1-10%, and chitin: LICL: DMAc system is by 1: (1-6): (100-800) preparation, solidification The weight ratio of bath DMAc: ethanol is (10-500): (90-50), and the solidified fiber is properly stretched. The stretch ratio is between 0.5-3 times, and the fibers are washed with detergent ethanol. 2. the manufacture method of chitin medical fiber paper according to claim 1 is characterized in that the monofilament fineness of this fiber is 0.56-11.1 dte ×, dry strength 1.34-1.78 CM/dtex, elongation 4-8%.