CN116212085A - A kind of preparation method of imitation skin dressing and imitation skin dressing - Google Patents

Abstract

The invention discloses a preparation method of an imitation skin dressing and the imitation skin dressing. The method part includes the following steps: S1 is used to electrospin the anionic water-based polyurethane spinning solution and the cationic water-based polyurethane spinning solution according to different specific gravity The process is a step of preparing a polyurethane layer; S2 is a step of heat-treating the polyurethane layer using a heat treatment process. S3 is used for the step of attaching the antibacterial layer to the heat-treated polyurethane layer; S4 is used for the step of attaching the wound surface contact layer to the antibacterial layer. The preparation method of the imitation skin dressing and the imitation skin dressing disclosed in the present invention have the same wrinkled appearance as the imitation skin, so that the polyurethane layer has high ductility, high elasticity and resilience, and can achieve dynamic fit with joints.

Description

A kind of preparation method of imitation skin dressing and imitation skin dressing

technical field

The invention relates to the technical field of medical dressings, in particular to a preparation method of an imitation skin dressing and the imitation skin dressing.

Background technique

Human skin is soft and has good extensibility, especially in joints, where the skin elongation rate exceeds 50%. There is a large amount of collagen in the skin. Collagen, as an extracellular protein, plays an important role in different stages of the wound healing process, and is closely related to cell proliferation, differentiation, and migration.

Currently, the existing dressing products on the market, including backing and core application, generally have a flat surface structure and limited stretching length, resulting in poor elasticity of the dressing, which cannot achieve dynamic fit with joints.

Contents of the invention

The purpose of the present invention is to provide a preparation method of an imitation skin dressing and an imitation skin dressing.

The preparation method of imitation skin dressing provided by the present invention may further comprise the steps:

S1 is used to prepare the anionic water-based polyurethane spinning solution and the cationic water-based polyurethane spinning solution into a polyurethane layer by using an electrospinning process according to different specific gravity;

S2 is a step of heat-treating the polyurethane layer using a heat-treatment process.

S3 is used for the step of bonding antibacterial layer to the polyurethane layer after heat treatment;

S4 is a step of attaching the wound contact layer to the antibacterial layer.

Preferably, the anionic water-based polyurethane spinning solution is prepared by mixing anionic water-based urethane accounting for 10-25%, cross-linking agent accounting for 0.5-5%, and a solvent.

Preferably, the cationic water-based polyurethane spinning solution is composed of cationic water-based urethane accounting for 10-25%, cross-linking agent accounting for 0.5-5%, hydrophobic agent accounting for 2-10% and Solvent blends are made.

Preferably, the solvent is one of dimethylformamide, ethanol, water or dimethyl sulfoxide; the crosslinking agent is polycarbodiimide, aziridine, isocyanate or epoxy silane One; the hydrophobic agent is one of polysiloxane, silane coupling agent or fluorine-free acrylic acid.

Preferably, the mixing ratio of the anionic aqueous polyurethane spinning solution to the cationic aqueous polyurethane spinning solution is 6:4, 5:5 or 4:6. Those skilled in the art can understand that the proportioning method without specific gravity can be used according to specific requirements, so as to obtain the polyurethane layer with the required ductility or support requirements.

Preferably, said S1 is used for the step of preparing an anionic water-based polyurethane spinning solution and a cationic water-based polyurethane spinning solution into a polyurethane layer by an electrospinning process according to different specific gravity, including:

S21 adopts spinning voltage: 10-30kV, receiving distance: 10-15cm, perfusion speed: 0.6-2mL/h, temperature 10-30℃, relative humidity: 25-70%, use three syringe pairs respectively The anionic water-based polyurethane spinning solution and the cationic water-based polyurethane spinning solution are spun side by side, and the steps of different ratios of the spinning solution are implemented by changing the infusion speed. S22: The step of exchanging the positions of the syringes filled with different water-based urethane spinning solutions every 1-2 hours at regular intervals, and continuing spinning to obtain a polyurethane layer.

Preferably, the antibacterial layer is made of hydrophilic polyurethane foam containing CHG (chlorhexidine gluconate), PHMB (polyhexamethylene biguanide hydrochloride) and silver ions.

Preferably, the heat treatment process is to use a vacuum oven, adjust the heating temperature to 40-80° C., and adjust the pressure to 10-101 kPa to heat the polyurethane layer for 10-120 minutes.

Preferably, the wound contact layer is made by mixing collagen accounting for 25-30%, acetic acid accounting for 15-20%, and a solvent, followed by electrospinning.

Preferably, the wound contact layer is made of collagen nanofibers or gelatin nanofibers.

The imitation skin dressing provided by the present invention comprises a polyurethane layer (1) and an antibacterial layer (2); the antibacterial layer (2) is attached to one side of the polyurethane layer (1); the polyurethane layer (1) Has an irregular wrinkled structure.

Preferably, the pleated structures are irregularly arranged at intervals.

Preferably, the imitation skin dressing provided by the present invention further includes an adhesive layer (3); the size of the adhesive layer (3) is the same as that of the polyurethane layer (1).

Preferably, the imitation skin dressing provided by the present invention also includes a wound contact layer (4); side.

Preferably, the size of the wound contact layer (4) is the same as that of the antibacterial layer (2).

The preparation method of a skin-like dressing and the skin-like dressing provided by the present invention present a skin-like wrinkle structure, so that the polyurethane layer has high ductility, high elasticity and recovery, so that the dressing can achieve dynamic contact with joints. fit.

Description of drawings

Fig. 1 is a schematic flow diagram of the preparation method of the imitation skin dressing described in Embodiment 1 of the present invention;

Fig. 2 is a schematic cross-sectional structure diagram of the imitation skin dressing described in Embodiment 2 of the present invention;

FIG. 3 is a schematic top view of the polyurethane layer described in Embodiment 2 of the present invention.

Detailed ways

In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments It is a part of embodiments of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

Embodiment one

As shown in Figure 1-3, the preparation method of the imitation skin dressing provided by the present embodiment comprises the following steps:

S1 is used to prepare the anionic water-based polyurethane spinning solution and the cationic water-based polyurethane spinning solution into a polyurethane layer by using an electrospinning process according to different specific gravity;

S2 is a step of heat-treating the polyurethane layer using a heat-treatment process.

S3 is used for the step of bonding antibacterial layer to the polyurethane layer after heat treatment;

S4 is a step of attaching the wound contact layer to the antibacterial layer.

Those skilled in the art can understand that by heat-treating the polyurethane layer, due to the different shrinkage rates of anionic water-based urethane nanofibers and cationic water-based urethane nanofibers in the polyurethane layer, the two will show different shrinkages in a tension-free state. Compared with each other, the two restrict each other, so that the skin-like dressing provided in this embodiment presents a wrinkled structure like skin-like, so that the polyurethane layer has high ductility, high elasticity and recovery, and can achieve dynamic fit with joints.

Further, the anionic water-based polyurethane spinning solution is prepared by mixing anionic water-based urethane accounting for 10-25%, cross-linking agent accounting for 0.5-5%, and solvent.

Further, the cationic water-based polyurethane spinning solution is composed of cationic water-based urethane accounting for 10-25%, cross-linking agent accounting for 0.5-5%, hydrophobic agent and solvent accounting for 2-10% Mix made.

Further, the solvent is one of dimethylformamide, ethanol, water or dimethyl sulfoxide; the crosslinking agent is one of polycarbodiimide, aziridine, isocyanate or epoxy silane species; the hydrophobic agent is one of polysiloxane, silane coupling agent or fluorine-free acrylic acid.

Further, the compounding ratio of the anionic water-based polyurethane spinning solution to the cationic water-based polyurethane spinning solution is 6:4, 5:5 or 4:6. Those skilled in the art can understand that the proportioning method without specific gravity can be used according to specific requirements, so as to obtain the polyurethane layer with the required ductility or support requirements.

Further, said S1 is used to prepare the anionic water-based polyurethane spinning solution and the cationic water-based polyurethane spinning solution into a polyurethane layer by electrospinning process according to different specific gravity, including:

S21 adopts spinning voltage: 10-30kV, receiving distance: 10-15cm, perfusion speed: 0.6-2mL/h, temperature 10-30℃, relative humidity: 25-70%, use three syringe pairs respectively The anionic water-based polyurethane spinning solution and the cationic water-based polyurethane spinning solution are spun side by side, and the steps of different ratios of the spinning solution are implemented by changing the infusion speed.

S22 The step of exchanging the positions of the syringes filled with different water-based polyurethanes every 1-2 hours at regular intervals, continuing spinning, and preparing the polyurethane layer.

Those skilled in the art can understand that the skin-like property of the polyurethane layer can be improved by regularly exchanging positions for spinning.

Further, the antibacterial layer is made of hydrophilic polyurethane foam containing CHG (chlorhexidine gluconate), PHMB (polyhexamethylene biguanide hydrochloride) and silver ions. Those skilled in the art can understand that the antibacterial layer is a hydrophilic polyurethane foam containing antibacterial drugs (CHG, PHMB, silver ions, etc.), which is used to absorb wound exudate and manage microorganisms in the absorbed liquid.

Further, the heat treatment process is to use a vacuum oven, adjust the heating temperature to 40-80° C., and adjust the pressure to 10-101 kPa to heat the polyurethane layer for 10-120 minutes. Those skilled in the art can understand that the shrinkage rates of the two polyurethane materials in the polyurethane layer are different, and wrinkles appear on the fiber membrane.

Further, the wound contact layer is made by mixing collagen accounting for 25-30%, acetic acid accounting for 15-20%, and a solvent, followed by electrospinning. Those skilled in the art can understand that the electrospinning conditions of the wound surface contact layer adopt spinning voltage: 10-30kV, receiving distance: 15-20cm, perfusion speed: 1-4mL/h, temperature 20-30°C, relative humidity: 25 -70%. Collagen is collagen or gelatin.

Further, the wound contact layer is made of collagen nanofibers or gelatin nanofibers. Those skilled in the art can understand that the wound contact layer simulates the natural extracellular matrix, and the void structure is conducive to cell adhesion and growth. The dressing can imitate the natural skin tissue structure in terms of raw materials and structure, and can promote cell survival and growth.

Embodiment two

The imitation skin dressing provided in this embodiment includes a polyurethane layer 1 and an antibacterial layer 2; the antibacterial layer 2 is attached to one side of the polyurethane layer 1; and the polyurethane layer 1 has a wrinkled structure. Those skilled in the art can understand that the imitation skin dressing provided in this embodiment presents a skin-like wrinkled appearance, so that the polyurethane layer 1 has high extensibility, high elasticity and resilience, and can achieve dynamic fit with joints.

Those skilled in the art can understand that the polyurethane layer is made of anionic water-based polyurethane spinning solution and cationic water-based polyurethane spinning solution according to different specific gravity by electrospinning. Water-based urethane and cationic water-based urethane have different shrinkage ratios. In the tension-free state, the two will show different shrinkage ratios. The two restrict each other, so that the skin-like dressing provided in this embodiment presents skin-like folds structure.

Those skilled in the art can understand that the anionic water-based polyurethane spinning solution is prepared by mixing anionic water-based urethane accounting for 10-25%, cross-linking agent and solvent accounting for 0.5-5%. The cationic water-based polyurethane spinning solution is prepared by mixing cationic water-based urethane accounting for 10-25%, cross-linking agent accounting for 0.5-5%, hydrophobic agent accounting for 2-10%, and solvent. become. The solvent is one of dimethylformamide, ethanol, water or dimethyl sulfoxide; the crosslinking agent is one of polycarbodiimide, aziridine, isocyanate or epoxy silane; The hydrophobic agent is one of polysiloxane, silane coupling agent or fluorine-free acrylic acid. The mixing ratio of the anionic water-based polyurethane spinning solution to the cationic water-based polyurethane spinning solution is 6:4, 5:5 or 4:6. Those skilled in the art can understand that the proportioning method without specific gravity can be used according to specific requirements, so as to obtain the polyurethane layer with the required ductility or support requirements.

Those skilled in the art will understand that the antibacterial layer 2 is made of hydrophilic polyurethane foam containing CHG chlorhexidine gluconate, PHMB polyhexamethylene biguanide hydrochloride and silver ions, and the hydrophilic polyurethane foam is used for Absorbs wound exudate, and it contains CHG, PHMB and silver ions while managing microorganisms in the absorbed fluid.

Further, the wrinkle structure is irregularly arranged at intervals.

Further, the imitation skin dressing provided in this embodiment also includes an adhesive layer 3 ; the size of the adhesive layer 3 is the same as that of the polyurethane layer 1 . Those skilled in the art can understand that the imitation skin dressing provided in this embodiment is fixed on the wound by sticking the adhesive layer 3 on the antibacterial layer 2 and the polyurethane layer 1 .

Further, the imitation skin dressing provided in this embodiment also includes a wound contact layer 4; the wound contact layer 4 is attached to the side of the adhesive layer 3 away from the antibacterial layer 2. Those skilled in the art can understand that the wound contact layer 4 is made by electrospinning after mixing 25-30% collagen, 15-20% acetic acid and a solvent. Collagen is collagen or gelatin, and the wound surface contact layer 4 is collagen nanofibers or gelatin nanofibers, which simulate natural extracellular matrix, and the void structure is conducive to cell adhesion and growth. Promote cell survival and growth.

Further, the size of the wound contact layer 4 is the same as that of the antibacterial layer 2 . Those skilled in the art can understand that if the size of the wound surface contact layer 4 is too large, it will be bonded to the polyurethane layer, resulting in a decrease in the bonding surface between the polyurethane layer and the skin, which will affect the sticking effect of the dressing, and also increase the materials used and increase the cost of the enterprise. ; The size is too small to achieve a good effect of promoting wound healing.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: it can still be Modifications are made to the technical solutions described in the foregoing embodiments, or equivalent replacements are made to some of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the various embodiments of the present invention.

Claims (15)

1. a preparation method of imitation skin dressing, is characterized in that, comprises the steps: S1 is used to prepare the anionic water-based polyurethane spinning solution and the cationic water-based polyurethane spinning solution into a polyurethane layer by using an electrospinning process according to different specific gravity; S2 is a step of heat-treating the polyurethane layer using a heat-treatment process. S3 is used for the step of bonding antibacterial layer to the polyurethane layer after heat treatment; S4 is a step of attaching the wound contact layer to the antibacterial layer. 2. the preparation method of imitation skin dressing as claimed in claim 1, is characterized in that, described anionic water-based polyurethane spinning solution is by accounting for 10-25% anionic water-based urethane, accounting for 0.5-5%. % made by mixing crosslinking agent and solvent. 3. the preparation method of imitation skin dressing as claimed in claim 2, is characterized in that, described cationic water-based polyurethane spinning solution is by accounting for 10-25% cationic water-based urethane, accounting for 0.5-5%. % crosslinking agent, 2-10% hydrophobic agent and solvent. 4. the preparation method of imitation skin dressing as claimed in claim 3 is characterized in that, described solvent is the one in dimethylformamide, ethanol, water or dimethyl sulfoxide; Described linking agent is One of polycarbodiimide, aziridine, isocyanate or epoxy silane; the hydrophobic agent is one of polysiloxane, silane coupling agent or fluorine-free acrylic acid. 5. the preparation method of imitation skin dressing as claimed in claim 4, is characterized in that, the hybridization ratio of described anionic water-based polyurethane spinning solution and described cationic water-based polyurethane spinning solution is 6:4,5:5 Or 4:6. Those skilled in the art can understand that the proportioning method without specific gravity can be used according to specific requirements, so as to obtain the polyurethane layer with the required ductility or support requirements. 6. the preparation method of imitation skin dressing as claimed in claim 5 is characterized in that, described S1 is used for anionic water-based polyurethane spinning liquid and cationic water-based polyurethane spinning liquid to adopt electrospinning process preparation according to different specific gravity The steps of forming a polyurethane layer include: S21 adopts spinning voltage: 10-30kV, receiving distance: 10-15cm, perfusion speed: 0.6-2mL/h, temperature 10-30℃, relative humidity: 25-70%, use three syringe pairs respectively The anionic water-based polyurethane spinning solution and the cationic water-based polyurethane spinning solution are spun side by side, and the steps of different ratios of the spinning solution are implemented by changing the infusion speed. S22: The step of exchanging the positions of the syringes filled with different water-based urethane spinning solutions every 1-2 hours at regular intervals, and continuing spinning to obtain a polyurethane layer. 7. the preparation method of imitation skin dressing as claimed in claim 6 is characterized in that, described antibacterial layer is made of containing CHG (chlorhexidine gluconate), PHMB (polyhexamethylene biguanide hydrochloride) and silver ion Made of hydrophilic polyurethane foam. 8. The preparation method of imitation skin dressing as claimed in claim 7, is characterized in that, described heat treatment process is to adopt vacuum oven, adjusts its heating temperature to be 40-80 ℃, and pressure is 10-101kPa, and polyurethane layer is heated 10-120 minutes. 9. The preparation method of imitation skin dressing as claimed in claim 8, is characterized in that, described wound surface contact layer is the collagen protein that accounts for 25-30%, the acetic acid that accounts for 15-20% and solvent mixes and carries out static electricity. Made by spinning process. 10. The preparation method of imitation skin dressing according to claim 9, characterized in that, the wound contact layer is made of collagen nanofibers or gelatin nanofibers. 11. A kind of imitation skin dressing, it is characterized in that, comprises polyurethane layer (1) and antibacterial layer (2); Described antibacterial layer (2) is fitted on a side of described polyurethane layer (1); Described polyurethane layer (1) It has a wrinkled structure. 12. The skin-imitating dressing according to claim 11, characterized in that, the wrinkled structures are irregularly arranged at intervals. 13. The imitation skin dressing according to claim 12, further comprising an adhesive layer (3); the size of the adhesive layer (3) is the same as that of the polyurethane layer (1). 14. The imitation skin dressing according to claim 13, further comprising a wound contact layer (4); the wound contact layer (4) is attached to the adhesive layer (3) away from the antibacterial One side of layer (2). 15. The imitation skin dressing according to claim 14, characterized in that the size of the wound contact layer (4) is the same as that of the antibacterial layer (2).

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