CN116148384A - Domestic LIMS and domestic HPLC data sharing method - Google Patents

Abstract

The invention relates to a domestic LIMS and domestic HPLC data sharing method, and belongs to the technical field of data sharing. Which comprises the following steps: generating quality control information of LIMS; pushing quality control information of LIMS; receiving detection information of HPLC; detection results of HPLC were generated: pushing detection results of HPLC: the experimenter logs in the HPLC, processes the bottom data of the data storage library to generate a report, and transmits the information of the test result to the LIMS through the HPLC; LIMS detection result receiving application: and (3) logging in the LIMS by an experimenter, selecting a sample, synthesizing an electronic experiment record book ELN and generating a test report, and ending the whole butt joint process.

Description

Domestic LIMS and domestic HPLC data sharing method

technical field

The invention relates to a domestic LIMS and domestic HPLC data sharing method, belonging to the technical field of data sharing.

Background technique

Laboratory Information Management System (LIMS) is the mainstream information management platform for inspection and testing laboratories. Instrument data collection is an important technology to ensure the reliability and traceability of inspection results. High-performance liquid chromatography (HPLC) is a common separation and analysis instrument in inspection and testing laboratories. Its test results include structured data and chromatographic test reports generated based on structured data.

At present, imported liquid chromatography workstations only provide chromatographic test reports and do not provide structured data. Domestic LIMS can only parse the chromatographic test report in PDF format into structured data through the analysis program, and then use it for electronic original records of domestic LIMS ( ELN). Domestic liquid chromatography workstations have the same problem. They do not provide structured data, but only chromatographic test reports. Domestic LIMS cannot realize the underlying data connection with it. The difference from imported instruments is that domestic HPLC suppliers are willing to cooperate with open underlying data interfaces. Provide structured data.

Chromatography test report in PDF format is prone to analysis errors during the analysis process, and for the entire data transfer process, from HPLC structured data → chromatogram test report → PDF analysis → structured data ELN application, in essence, artificially increased The process of PDF generation and parsing not only wastes resources, reduces efficiency, but is also prone to errors, which is also the main source of failures in LIMS operation and maintenance in practice.

The direct docking of the underlying structured data of HPLC-LIMS avoids the disadvantages caused by the generation and analysis of the PDF chromatographic test report. , the PDF chromatographic test report is still used as a LIMS attachment for unstructured data delivery.

Contents of the invention

The purpose of the present invention is to provide a domestic LIMS and domestic HPLC data sharing method, which can realize information sharing and data traceability, and avoid the disadvantages of error-prone data analysis.

In order to achieve the above object, the present invention is achieved through the following technical solutions:

A domestic LIMS and domestic HPLC data sharing method, comprising the following steps:

S1. LIMS inspection information generation:

The experimenter logs in to LIMS, clicks on the liquid phase push, selects the sample, and the inspection item information, and saves it in the inspection product information database to be pushed;

S2. LIMS inspection information push:

The experimenter logs in to LIMS, selects the test product to be pushed, and after clicking on the instrument, the information of the test product to be pushed is sent from LIMS to the designated HPLC;

S3. HPLC detection information reception:

The experimenter logs in to the HPLC, pushes the sample information to the LIMS, and clicks to enter the library of samples to be imported;

The detection result of S4.HPLC is generated:

The experimenter logs in to the HPLC, clicks on the sample to be injected and starts to inject the sample. After the sample is injected, the result is automatically stored in the data repository;

S5.HPLC test result push:

The experimenters log in to the HPLC, process the underlying data of the HPLC repository to generate a report, and transmit the structured data and report to the LIMS from the HPLC according to the preset format;

S6.LIMS test result receiving application:

The experimenter logs into LIMS, selects the sample, selects HPLC to push the structured data and chromatographic test report, synthesizes ELN and generates the test report, and the whole docking process ends from then on.

The preferred scheme of the domestic LIMS and domestic HPLC data sharing method, the HPLC repository data includes system suitability test data, parallel experiment data, sample detection data, standard curve data, the above data are structural data; and non-structural data such as chromatographic detection reports data.

In the preferred scheme of the domestic LIMS and domestic HPLC data sharing method, the LIMS client and HPLC workstation are respectively connected to the LIMS application server through the floor switch and the core switch, and lock the communication through the IP address of the HPLC.

The advantages of the present invention are:

1. Compared with the application data after PDF analysis by application analysis software, the automatic transmission of the underlying structured data will not cause analysis errors, can be traced back, and is more in line with compliance requirements.

2. Compared with the association of the factory number of the instrument, the instrument LAN ID is used to match the instrument, and the instrument LAN ID and the floor switch are maintained in advance through the LIMS instrument management module. The communication method is equivalent to a dedicated line, and there will be no transmission errors.

ID matching instrument is the original method of this method, which is suitable for instrument positioning when multiple instruments exist in the same network. For floor switches, the conventional configuration strategy is automatic matching, as long as 1 to 255 in the host position is not occupied, it can be selected. The hard-coded strategy refers to artificially specifying a certain number in the host position for a certain instrument. Maintain static data such as IDs corresponding to multiple instruments into the LIMS instrument management module in advance, and then you can associate the instrument with the ID. When you select an instrument in LIMS, it will automatically match the ID associated with the instrument, thereby realizing a dedicated line with the instrument Communication, there will be no poor communication.

The communication between LIMS and instruments has tried to use the instrument factory number, instrument serial number, inspection product number, hospital instrument number, etc. A connection can be established and is stable.

3. Both the structured data and the PDF chromatographic test report as an attachment have realized data sharing. The ELN synthesis is convenient and fast, and there is no need to repeatedly enter data, which improves work efficiency and reduces server burden and data redundancy.

Description of drawings

The accompanying drawings are used to provide a further understanding of the present invention, and constitute a part of the description, and are used together with the embodiments of the present invention to explain the present invention, and do not constitute a limitation to the present invention.

Fig. 1 is a schematic diagram of the communication between the LIMS client and the HPLC workstation of the present invention.

Detailed ways

The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

The present invention decomposes the whole process of LIMS and HPLC underlying data interconnection into 6 parts, including inspection information generation and reception, inspection result generation, push and reception, and inspection result generation, so as to realize information sharing and data traceability, and avoid data Parse error-prone drawbacks.

A domestic LIMS and domestic HPLC data sharing method, comprising the following steps:

S1. LIMS inspection information generation:

The experimenters log in to LIMS, and store the information of liquid phase push, sample selection and test item selection in the information database of test items to be pushed. This step supports single and multiple selection of samples and test items;

S2. LIMS inspection information push:

The experimenter logs in to LIMS, and transmits information about the product to be pushed, sample selection and instrument selection from LIMS to HPLC. This step supports single-selection and multiple-selection of samples, including inspection item information;

S3. HPLC detection information reception:

The experimenter logs in to the HPLC and enters the sample information into the sample library to be imported. The experimenter uses his own account number and password, and can only choose his own LIMS account number and password to send information, and this step supports single selection and multiple selection;

The detection result of S4.HPLC is generated:

The experimenters log in to the HPLC, and after the sample injection is completed, the results are automatically stored in the data repository. The data in the data repository includes system suitability test data, parallel experiment data, sample detection data, and standard curve data. The above data is structural data;

S5.HPLC test result push:

The experimenters log in to the HPLC, process the underlying data of the data repository to generate a report, and transmit the inspection result information from the HPLC to the LIMS, and the system suitability test data, parallel experiment data, sample detection data, standard curve data and other structured data are automatically stored in the ELN In the corresponding position, the chromatographic test report is stored as an attachment in the inspection product attachment library, and it supports synthesis to ELN;

S6.LIMS test result receiving application:

The experimenter logs into LIMS, selects samples, synthesizes the electronic experiment record book ELN, and generates an inspection report. Since then, the whole docking process is over.

In this embodiment, the HPLC workstation runs on the instrument computer, and the LIMS runs on the server in the core computer room. Experimenters log in to the LIMS client through the office computer (office computer), log in to the HPLC workstation through the instrument computer, and the LIMS client and HPLC workstation respectively through the floor switch. , The core switch is connected to the LIMS application server.

Finally, it should be noted that: the above is only a preferred embodiment of the present invention, and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, for those skilled in the art, it still The technical solutions recorded in the foregoing embodiments may be modified, or some technical features thereof may be equivalently replaced. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included within the protection scope of the present invention.

Claims (3)

1. The domestic LIMS and domestic HPLC data sharing method is characterized by comprising the following steps:

s1, generating inspection product information of LIMS:

the experimenter logs in the LIMS, and pushes the liquid selection phase, selects a sample and selects test item information to store in a to-be-pushed sample information base;

s2, pushing quality inspection information of LIMS:

the experimenter logs in the LIMS, and the information of the to-be-pushed samples, the selected samples and the selected instrument information are transmitted from the LIMS to the HPLC;

s3, receiving detection information of HPLC:

the experimenter logs in the HPLC, inputs the sample information into the sample library to be sampled;

s4, generating a detection result of HPLC:

the experimenter logs in the HPLC, after the sample injection is finished, the result is automatically stored in a data storage library;

s5, pushing the detection result of HPLC:

the experimenter logs in the HPLC, processes the bottom data of the data storage library to generate a report, and transmits the information of the test result and the report to the LIMS through the HPLC;

s6, detecting result receiving application of LIMS:

and (3) logging in the LIMS by an experimenter, selecting a sample, synthesizing an electronic experiment record book ELN and generating a test report, and ending the whole butt joint process.

2. The method for sharing domestic LIMS and domestic HPLC data according to claim 1, wherein: the HPLC memory bank data comprises system applicability test data, parallel test data, sample detection data and standard curve data, wherein the data are structural data.

3. The method for sharing domestic LIMS and domestic HPLC data according to claim 1 or 2, wherein: the LIMS user side and the HPLC workstation are respectively connected with the LIMS application server through the floor switch and the core switch, and establish communication through the IP of the HPLC.

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