CN116115258A - Ultrasonic diagnostic and therapeutic equipment - Google Patents
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- 238000011065 in-situ storage Methods 0.000 description 4
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Abstract
The invention provides ultrasonic diagnosis and treatment equipment, belongs to the technical field of ultrasonic treatment, and can at least partially solve the problem that the existing ultrasonic treatment cannot ensure the accurate focus position. In the ultrasonic diagnosis and treatment equipment, the control module is used for controlling the ultrasonic emission module and the detection module to carry out the following working procedures: diagnosis stage: the ultrasonic transmitting module respectively transmits detection ultrasonic waves by taking each position in a preset range as a theoretical focus; the detection module receives the secondary sound wave and determines a corresponding property distribution diagram according to the secondary sound wave; detecting the tissue vibration at the actual focus excited by ultrasonic energy to emit secondary sound waves, wherein the corresponding property distribution diagram comprises the corresponding properties of each position in a preset range, and the corresponding property of each position is the property of the tissue determined according to the secondary sound waves when the theoretical focus is positioned at the position; treatment stage: the ultrasonic transmitting module transmits therapeutic ultrasonic waves by taking the target position as a theoretical focus.
Description
Technical Field
The invention belongs to the technical field of ultrasonic treatment, and particularly relates to ultrasonic diagnosis and treatment equipment.
Background
High intensity focused ultrasound (HIFU, high Intensity Focused Ultrasound) refers to a technique that focuses ultrasonic waves emitted from a plurality of locations at a single focal point (target point), thereby generating ultrasonic waves of very high intensity in the focal point (including the vicinity of the focal point, i.e., focal region). Wherein, the ultrasonic wave can be focused at the tissue to be treated in the human body to treat the tissue to be treated (such as coagulating necrosis of lesion tissue), namely, ultrasonic treatment.
To avoid damaging normal tissue, the ultrasound waves need to be accurately focused at the tissue to be treated. However, the human body is not a uniform acoustic medium but a complex viscoelastic nonlinear body, so that the ultrasonic wave does not propagate in a straight line in the human body, and thus, the position of the actual focal point of the ultrasonic wave in the human body may be different from the theoretical focal point position when the ultrasonic wave propagates in a uniform acoustic medium (straight line propagation). The actual focal position of the ultrasound wave is uncertain and difficult to predict.
Disclosure of Invention
The invention at least partially solves the problem that the existing ultrasonic treatment cannot ensure the accurate focus position, and provides ultrasonic diagnosis treatment equipment capable of ensuring that the treatment ultrasonic energy is accurately focused at the position to be treated.
In a first aspect, an embodiment of the present invention provides an ultrasonic diagnostic and therapeutic apparatus, which includes an ultrasonic transmitting module, a detecting module, and a control module; wherein,,
the control module is used for controlling the ultrasonic transmitting module and the detecting module to carry out the following working procedures:
diagnosis stage: the ultrasonic transmitting module respectively transmits detection ultrasonic waves by taking each position in a preset range as a theoretical focus; the detection module receives the secondary sound wave and determines a corresponding property distribution diagram according to the secondary sound wave; the detection ultrasonic energy excites tissue vibration at an actual focus to emit the secondary sound wave, the corresponding property distribution map comprises corresponding properties of all positions in the preset range, and the corresponding property of each position is the property of the tissue determined according to the secondary sound wave when the theoretical focus is at the position;
treatment stage: the ultrasonic transmitting module transmits therapeutic ultrasonic waves by taking the target position as a theoretical focus; the target location is within a predetermined range and the therapeutic ultrasound energy treats tissue.
Optionally, before the ultrasonic transmitting module sends out the therapeutic ultrasonic wave with the target position as the theoretical focus, the treatment stage further includes:
the control module determines at least one location from the predetermined range as the target location based on the corresponding property profile obtained in the detection stage.
Optionally, the workflow further comprises, after the treatment stage:
evaluation phase: the ultrasonic transmitting module at least takes the target position as a theoretical focus to transmit the detection ultrasonic wave; the detection module receives the secondary sound wave and at least determines the corresponding property of the target position according to the secondary sound wave.
Optionally, the ultrasonic transmitting module at least uses the target position as a theoretical focus to transmit the detection ultrasonic wave; the detection module receives the secondary sound wave, and at least determining the corresponding property of the target position according to the secondary sound wave comprises:
the ultrasonic transmitting module respectively transmits the detection ultrasonic waves by taking each position in a preset range as a theoretical focus; and the detection module receives the secondary sound wave and determines a corresponding property distribution diagram according to the secondary sound wave.
Optionally, the ultrasonic transmitting module respectively uses each position in the predetermined range as a theoretical focus to send out the detection ultrasonic wave, including:
and the ultrasonic transmitting module sequentially and respectively transmits detection ultrasonic waves by taking each position in a preset range as a theoretical focus according to a preset scanning path.
Optionally, the property of the tissue comprises a mechanical property and/or an acoustic property of the tissue.
Optionally, the power of the detected ultrasonic wave is 1 to 10W;
the power of the therapeutic ultrasonic wave is 20W to 500W.
Optionally, the frequency of the detection ultrasonic wave is between 500kHz and 10MHz;
the therapeutic ultrasound has a frequency of 500kHz to 10MHz.
Optionally, the detection ultrasonic wave is a single-frequency ultrasonic wave or a difference-frequency ultrasonic wave.
Optionally, the detection ultrasound is used to vibrate tissue at the actual focal point to emit a secondary sound wave by at least one of:
amplitude modulation, beat frequency interference, pulse excitation, standing wave interference.
In the invention, focused detection ultrasonic waves are sent out by an ultrasonic emission module in a diagnosis stage, and tissues at an actual focus are excited to send out secondary sound waves, and the target position to be treated is determined according to the secondary sound waves; thus, in the subsequent treatment stage, the same ultrasonic transmitting module can be used for transmitting focused treatment ultrasonic waves to the target position in the same acoustic environment, so that the treatment ultrasonic waves can be precisely focused at the position which is actually required to be treated.
In a word, the invention uses one ultrasonic emission module to diagnose and treat, thus realizing the 'integration' and 'in situ' of diagnosis and treatment, thereby ensuring that the therapeutic ultrasonic energy is focused at the position which is actually needed to treat, improving the treatment effect, reducing the damage to normal tissues, and simultaneously, having lower requirements on hardware and algorithm (because the actual focus position is not needed to be predicted), being easy to realize and having low cost.
Drawings
FIG. 1 is a block diagram schematically showing the constitution of an ultrasonic diagnostic and therapeutic apparatus according to an embodiment of the present invention;
FIG. 2 is a block diagram schematically illustrating the constitution of another ultrasonic diagnostic and therapeutic apparatus according to an embodiment of the present invention;
FIG. 3 is a schematic diagram of a workflow performed by an ultrasonic diagnostic and therapeutic apparatus according to an embodiment of the present invention;
FIG. 4 is a schematic diagram of a workflow performed by another ultrasonic diagnostic treatment apparatus according to an embodiment of the present invention;
fig. 5 is a schematic diagram of the relationship between the actual focus and the theoretical focus of ultrasonic waves.
Detailed Description
The present invention will be described in further detail below with reference to the drawings and detailed description for the purpose of better understanding of the technical solution of the present invention to those skilled in the art.
It is to be understood that the specific embodiments and figures described herein are merely illustrative of the invention, and are not limiting of the invention.
It is to be understood that the various embodiments of the invention and the features of the embodiments may be combined with each other without conflict.
It is to be understood that, for convenience of description, only portions related to the embodiments of the present invention are shown in the drawings, and portions unrelated to the embodiments of the present invention are not shown in the drawings.
In some related art, when using High Intensity Focused Ultrasound (HIFU) for treatment, it is desirable to accurately focus the ultrasound waves at the tissue to be treated.
However, since the human body is not a uniform acoustic medium but a complex viscoelastic nonlinear body, the ultrasonic wave does not propagate straight in the human body, and thus, referring to fig. 5, the position of the actual focal point of the ultrasonic wave in the human body may be different from the theoretical focal point position when the ultrasonic wave propagates in the uniform acoustic medium (straight propagation).
To solve the above problem, one way is to approximate that the ultrasonic waves (or most of the ultrasonic energy) are uniformly propagated along a straight line in the human tissue, i.e., focused at the theoretical focal point. However, the above approximation obviously does not conform to the actual situation, and the actual focus of the therapeutic ultrasonic wave deviates from the tissue to be treated, so that normal tissues are damaged, and the therapeutic effect is reduced.
Another way to solve the above problem is to use some strategy to predict, estimate the actual focus position in the current specific acoustic environment before treatment. However, the human body tissue condition is complex, so the implementation difficulty of the mode is high, the system hardware and the prediction algorithm are required to be high, and the accuracy of the predicted focus position is still limited.
In a first aspect, an embodiment of the present invention provides an ultrasonic diagnostic treatment apparatus.
The ultrasonic diagnosis treatment device provided by the embodiment of the invention is used for diagnosing a patient through ultrasonic waves, determining the property (corresponding property distribution diagram) of the part to be treated, and performing HIFU treatment on the part to be treated, such as treatment of benign and malignant tumors such as hysteromyoma.
Referring to fig. 1, an ultrasonic diagnostic and therapeutic apparatus of an embodiment of the present invention includes an ultrasonic transmitting module, a detecting module, and a control module.
The ultrasonic transmitting module is used for transmitting focused ultrasonic waves, and the ultrasonic waves transmitted by the ultrasonic transmitting module have a definite theoretical focus, namely, when the ultrasonic waves transmitted by the ultrasonic transmitting module propagate in a uniform acoustic medium, the ultrasonic waves are focused at the theoretical focus.
For example, referring to fig. 2, the ultrasound transmitting module includes an ultrasound transducer (e.g., including a plurality of piezoelectric devices and, of course, corresponding power supply, cooling, etc. auxiliary systems) for emitting ultrasound from a transmitting surface, which may be a portion of a sphere, such as a spherical cap surface (see fig. 5), a spherical segment surface, two opposing spherical cap surfaces, etc., where the theoretical focus of the emitted ultrasound is located at the center of the sphere.
When the ultrasonic transducer is in the form of a spherical segment surface, two opposite spherical crown surfaces and the like, the transmitting surface of the ultrasonic transducer can also have the capability of reflecting ultrasonic waves, so that ultrasonic waves emitted from the other side can be reflected back, standing waves are formed at the spherical center, and the ultrasonic intensity at the focus is further improved.
Referring to fig. 2, the ultrasonic transmitting module further includes a driver for driving the ultrasonic transducer to move (e.g. move or rotate), so that the ultrasonic transducer moves in space, which is equivalent to that the theoretical focus moves in space, and thus the ultrasonic transmitting module can emit ultrasonic waves for the theoretical focus at different positions in space.
The actual focusing position of the ultrasonic wave emitted by the ultrasonic transmitting module is an actual focus, and when the acoustic medium is not uniform (such as including human tissues), referring to fig. 5, the actual focus may deviate from the theoretical focus.
In the embodiment of the invention, the ultrasonic transmitting module can emit ultrasonic waves with different characteristics (such as intensity, frequency, amplitude and the like), so that the ultrasonic waves have different functions, namely the ultrasonic transmitting module can emit detection ultrasonic waves and treatment ultrasonic waves.
The intensity of the therapeutic ultrasonic wave is high, so that the therapeutic ultrasonic wave can denature the tissue (human tissue) at the actual focus (such as coagulation necrosis of lesion tissue) so as to treat the tissue.
The intensity of the detected ultrasonic wave is low, so that the tissue at the actual focus is not denatured enough, i.e. the tissue is not permanently influenced. However, detecting ultrasound waves can cause tissue at the actual focal point to vibrate (e.g., vibrate at a low frequency), and the vibration of the tissue can emit "new" sound waves, i.e., emit "secondary sound waves (the frequency of which does not necessarily fall within the ultrasound range)".
Obviously, when the tissue at the actual focal point is different (e.g., different human tissue) for the same detected ultrasonic wave, the vibration conditions generated by the tissue are different, so that the characteristics (e.g., intensity, frequency, amplitude, etc.) of the corresponding generated secondary acoustic wave are also different, i.e., the characteristics of the secondary acoustic wave are related to the properties of the tissue at the actual focal point.
Thus, the detection module may receive the above secondary sound waves and analyze the characteristics of the secondary sound waves to determine the nature of the tissue from which the secondary sound waves emanate, i.e., by analyzing the secondary sound waves, the nature of the corresponding tissue may be distinguished (e.g., to determine what tissue is and whether a lesion has occurred in the tissue).
Wherein referring to fig. 2, the detection module may include an acquisition unit (e.g., one or more hydrophones) that acquires the secondary sound waves, and an analysis unit (e.g., a processor) for analyzing the secondary sound waves.
Obviously, the characteristic of the detected ultrasonic wave is obviously different from the characteristic of the secondary sound wave excited by the ultrasonic wave, so that the detection module can accurately obtain the secondary sound wave signal. For example, because the frequency of the secondary sound wave is low and the directivity is weak, the acquisition unit can be positioned outside the sound channel of the detection ultrasonic wave, the detection ultrasonic wave is not received, and only the secondary sound wave is received; alternatively, the acquisition unit may sense only the characteristics of the secondary sound wave (such as the frequency of the secondary sound wave is typically between several hundred hz and several hundred KHz, and the lower limit of the frequency of the detected ultrasonic wave is also above 500 KHz); alternatively, the analysis unit may analyze the signals of all the sound waves to separate therefrom the secondary sound wave signals of a specified characteristic (e.g., a specified frequency).
It should be understood that referring to fig. 2, other modules, such as a support module (e.g., a treatment couch) for supporting a patient's body, a medium module for containing an acoustic medium (e.g., deaerated water), a purification module (e.g., a deaerating device) for providing an acoustic medium, etc., may be included in the ultrasonic diagnostic treatment apparatus according to the embodiments of the present invention, and will not be described in detail herein.
The specific form, number, positional relationship, etc. of the above modules are various, and will not be described in detail herein.
Referring to fig. 3, in an embodiment of the present invention, the control module is configured to control the ultrasonic transmitting module and the detecting module to perform the following working procedures.
S101, diagnosis stage: the ultrasonic transmitting module respectively transmits detection ultrasonic waves by taking each position in a preset range as a theoretical focus; the detection module receives the secondary sound wave and determines a corresponding property distribution diagram according to the secondary sound wave.
The method comprises the steps of detecting tissue vibration at an actual focus excited by ultrasonic energy to emit secondary sound waves, wherein a corresponding property distribution diagram comprises corresponding properties of each position in a preset range, and the corresponding property of each position is determined according to the secondary sound waves when a theoretical focus is positioned at the position.
S102 treatment phase: the ultrasonic transmitting module transmits therapeutic ultrasonic waves by taking the target position as a theoretical focus.
Wherein the target location is within a predetermined range and the therapeutic ultrasound energy treats the tissue.
In the embodiment of the invention, a control module (such as an upper computer) is further arranged for controlling other modules to work according to a certain working procedure, wherein the working procedure specifically comprises a diagnosis stage and a subsequent treatment stage.
In the diagnosis stage, the control module can control the ultrasonic transmitting module to move (for example, the ultrasonic transducer is driven by the driver) so as to respectively take each position in a preset range as a theoretical focus and emit detection ultrasonic waves.
When the theoretical focus of the detected ultrasonic wave is positioned at any position A, the detection module can receive the secondary sound wave and determine the property B of the tissue emitting the secondary sound wave according to the secondary sound wave, wherein the property B is actually the property of the tissue at the actual focus (position B') of the detected ultrasonic wave; where location B' may be different from location a, but embodiments of the present invention do not distinguish it, but instead determine that the "corresponding property" of location a is property B.
Or it can be understood that any position a has a "corresponding position", that is, when the theoretical focus is located at position a, the position where the actual focus is located is the "corresponding position" of position a; thus, the "corresponding property" of location a, i.e., the property of the tissue of its corresponding location.
Thus, in the diagnosis stage, the "corresponding property" of each position in the predetermined range can be determined, that is, the "corresponding property distribution map" is obtained, and there is a point "pixel" corresponding to each position in the predetermined range in the corresponding property distribution map, where the "pixel value" of the pixel is the corresponding property of the corresponding position (that is, the property of the tissue at the actual focal point when the theoretical focal point of the detected ultrasonic wave is located at the pixel).
The above "predetermined range" is an approximate region where a predetermined treatment site is located, that is, by diagnosing the region, it can be determined where a specific treatment should be performed; for example, a range of B-mode images may be acquired, and the approximate region (predetermined range) where the approximate treatment site is located may be determined by analyzing the B-mode images.
The predetermined range may be a planar two-dimensional region or a stereoscopic three-dimensional region; accordingly, the corresponding property profile may be a "two-dimensional image" or a "three-dimensional image".
Wherein the pixel value forms of the pixels of the corresponding property distribution map are various. For example, the corresponding color and gray scale obtained by converting the corresponding property are taken as a pixel value, so that the corresponding property distribution map is an image; alternatively, specific parameter values (such as hardness values) of the corresponding properties can be directly used as "pixel values", so that the corresponding property distribution map is actually a "list" of some column data; in summary, it is possible as long as the pixel value of each pixel point can "embody" its corresponding property.
Thus, after the diagnosis phase, the position to be treated, i.e. the target position, within the predetermined range can be determined based on the above theoretical property profile.
The specific manner in which the target location is determined is varied.
For example, referring to fig. 4, before the ultrasound transmission module emits the therapeutic ultrasound with the target position as the theoretical focus, the treatment phase (S102) further includes:
s1020, the control module determines at least one position as a target position from a preset range according to the corresponding property distribution diagram obtained in the detection stage.
As a way of this embodiment of the present invention, the control module may analyze the corresponding property profile according to a preset program to determine a target position to be treated (for example, a target position with a pixel point whose corresponding property is significantly different from that of the other pixels) from the corresponding property profile, and mark the target position in the corresponding theoretical property profile.
It should be appreciated that it is also possible for the operator to view the corresponding property profile, manually determine the target location therefrom, and input it to the control module.
The target position may be one position, may be all the positions of one region, or may be a plurality of independent positions separated from each other, and it is determined specifically what tissue is to be treated according to the need.
Thus, during the treatment phase, the control module can control the position of the ultrasonic transmitting module to move (for example, the ultrasonic transducer is driven by the driver) so that the ultrasonic transmitting module takes the target position as a theoretical focus to emit treatment ultrasonic waves for treatment.
Because the therapeutic ultrasonic wave and the detection ultrasonic wave are sent out by adopting one ultrasonic emission module, the position and the angle of the therapeutic ultrasonic wave sent out to the same position A in the treatment stage are the same as the position and the angle of the detection ultrasonic wave sent out to the same position and the angle in the diagnosis stage (namely ' in-situ emission '), namely the acoustic environment experienced by the therapeutic ultrasonic wave and the detection ultrasonic wave is the same (the patient is required to keep still of course), the propagation paths are the same, the position of the actual focus is the same, namely, the therapeutic ultrasonic wave and the detection ultrasonic wave are actually focused at the position B '.
Thus, when it is determined from the corresponding property that the treatment is required for the position a (the theoretical focus of the detected ultrasonic wave), the tissue actually representing the position B' (the actual focus of the detected ultrasonic wave) is required for the treatment; the actual focus of the therapeutic ultrasonic wave emitted by taking the position A as the theoretical focus is also the position B ', namely, the therapeutic ultrasonic wave is actually focused at the position B', so that the tissue actually needing to be treated can be effectively treated.
In the invention, focused detection ultrasonic waves are sent out by an ultrasonic emission module in a diagnosis stage, and tissues at an actual focus are excited to send out secondary sound waves, and the target position to be treated is determined according to the secondary sound waves; thus, in the subsequent treatment stage, the same ultrasonic transmitting module can be used for transmitting focused treatment ultrasonic waves to the target position in the same acoustic environment, so that the treatment ultrasonic waves can be precisely focused at the position which is actually required to be treated.
In a word, the invention uses one ultrasonic emission module to diagnose and treat, thus realizing the 'in-situ integration' of diagnosis and treatment, thereby ensuring that the therapeutic ultrasonic energy is accurately focused at the position which is actually required to be treated, improving the treatment effect, reducing the damage to normal tissues, and simultaneously, having lower requirements on hardware and algorithm (because the actual focus position is not required to be predicted), being easy to realize and having low cost.
Optionally, the workflow of the embodiment of the present invention further includes, after the treatment stage (S102):
s103, evaluation stage: the ultrasonic transmitting module at least takes the target position as a theoretical focus to transmit detection ultrasonic waves; the detection module receives the secondary sound wave and at least determines the corresponding property of the target position according to the secondary sound wave.
As one mode of the embodiment of the invention, after the treatment stage, the ultrasonic transmitting module can be used again, according to the same acoustic environment, at least the detected ultrasonic waves are sent out to the treated target position, and at least the corresponding property of the treated target position is determined according to the secondary acoustic waves.
Therefore, the embodiment of the invention can obtain the corresponding property of the target position after treatment (namely the property of the tissue actually influenced by the treatment ultrasonic wave) so as to determine whether the property of the corresponding tissue is changed, and the treatment effect is evaluated, so that the diagnosis and treatment evaluation of 'in-situ integration' is further realized.
Alternatively, referring to fig. 4, the ultrasonic emission module emits the detection ultrasonic wave at least with the target position as the theoretical focus; the detection module receives the secondary sound wave, and at least determining the corresponding property of the target position according to the secondary sound wave (S103) comprises:
s1031, respectively sending out detection ultrasonic waves by the ultrasonic emission module by taking each position in a preset range as a theoretical focus; the detection module receives the secondary sound wave and determines a corresponding property distribution diagram according to the secondary sound wave.
As a way of this embodiment of the present invention, in order to obtain a more comprehensive evaluation result, it is also possible to send out detection ultrasonic waves at all positions within a predetermined range during the evaluation stage, so as to obtain a complete corresponding property profile after treatment, and compare the complete corresponding property profile with the corresponding property profile before treatment (for example, to determine whether the normal tissue is damaged).
Alternatively, referring to fig. 4, the ultrasonic transmission module respectively emits the detection ultrasonic waves with each position within the predetermined range as the theoretical focus (S101) including:
s1011, the ultrasonic transmitting module sequentially and respectively transmits detection ultrasonic waves by taking each position in a preset range as a theoretical focus according to a preset scanning path.
In the diagnosis stage, the focused detection ultrasonic waves can be sent out to a plurality of continuous positions on the path in sequence, namely, the preset range is comprehensively diagnosed in a scanning mode, so that the total movement amount of the ultrasonic transmitting module is reduced as much as possible.
It should be appreciated that if there are multiple target locations that make up a continuous region during a treatment session, focused treatment ultrasound may also be delivered to each target location within the continuous region by means of a "scan".
It will be appreciated that if an evaluation phase is present, the predetermined range may also be evaluated by means of a "scan", and that the scan path used therein may be the same as that in the diagnostic phase to maximize the comparability of the two results.
Optionally, the property of the tissue comprises a mechanical property and/or an acoustic property of the tissue.
As a way of determining the properties of the tissue by the secondary acoustic waves, the properties of the tissue may include, in particular, mechanical properties of the tissue (e.g., stiffness of the tissue, elasticity of the tissue, etc.), acoustic properties (e.g., acoustic attenuation in the tissue, sound velocity in the tissue, etc.).
Optionally, the power of the detected ultrasonic wave is 1W to 10W;
the power of the therapeutic ultrasonic wave is 20W to 500W.
The main difference between the detection ultrasonic wave and the treatment ultrasonic wave used in the embodiment of the invention is that the intensity (energy) is different, and the intensity of the detection ultrasonic wave is lower, so that only tissue vibration at an actual focus can be excited, but the tissue denaturation can not be caused; the intensity of the therapeutic ultrasonic wave is higher, so that the tissue at the actual focal point can be denatured to realize the treatment.
Specifically, the power of the detected ultrasonic wave can be 1-10W, further can be 2-8W, and further can be 4-6W; the power of the therapeutic ultrasonic wave can be 20-500W, further can be 50-400W, and further can be 100-300W.
Optionally, the frequency of the detected ultrasonic wave is between 500kHz and 10MHz;
the therapeutic ultrasound has a frequency of 500kHz to 10MHz.
In the embodiment of the invention, the frequency of the detection ultrasonic wave and the frequency of the treatment ultrasonic wave can also be different so as to be respectively suitable for the respective functions. Specifically, the frequency of the detected ultrasonic wave can be between 0.5 and 10MHz, further can be between 1 and 8MHz, and further can be between 2 and 6MHz; the frequency of the therapeutic ultrasonic wave can be between 0.5 and 10MHz, further between 1 and 8MHz, and further between 2 and 6MHz.
Accordingly, the frequency of the secondary acoustic wave generated by the above detection ultrasonic excitation may be generally in the range of 100Hz to 400KHz, and further may be in the range of 500Hz to 200KHz.
Alternatively, the detection ultrasonic wave is a single-frequency ultrasonic wave or a difference-frequency ultrasonic wave.
As a way of an embodiment of the present invention, only one single frequency ultrasonic wave may be used as the detection ultrasonic wave to excite the secondary acoustic wave.
Alternatively, as another mode of the embodiment of the present invention, two kinds of ultrasonic waves having different frequencies may be emitted to the focal point as the detection ultrasonic waves, and these two kinds of ultrasonic waves constitute "beat frequency", and the "beat frequency" ultrasonic waves are used to generate a dynamic acoustic radiation force to drive the vibration of the tissue at the focal point, so that the tissue at the focal point can be excited to generate vibration in a range approximating the difference between the frequencies of the two ultrasonic waves, so as to excite the secondary acoustic wave.
It should be understood that the detection ultrasonic wave is "single frequency", meaning that the detection ultrasonic wave emitted at one moment in time has only one frequency, and does not represent that the detection ultrasonic waves emitted at different times (e.g., in different diagnostic phases) can only be of the same frequency.
Optionally, the detection ultrasound is used to vibrate tissue at the actual focal point to emit a secondary sound wave by at least one of:
amplitude modulation, beat frequency interference, pulse excitation, standing wave interference.
As one way of the embodiment of the present invention, the detection ultrasonic wave may vibrate the tissue at the actual focal point by different ways (principles) to excite the secondary acoustic wave, such as amplitude modulation, beat frequency interference, pulse excitation, standing wave interference, etc.
The amplitude modulation is to multiply a low-frequency sine or cosine signal with a high-frequency detection ultrasonic signal to realize a mode of generating a secondary sound wave twice as high as the low-frequency signal at an actual focus.
Beat interference is the above manner of exciting the secondary sound wave by "difference frequency" ultrasound.
Pulsed excitation refers to the manner in which tissue at the actual focal point is excited with a short detection acoustic pulse, producing transient secondary sound waves at the actual focal point by transient acoustic radiation forces.
And standing wave interference refers to a manner in which at least part of the surface of an ultrasonic transducer can reflect ultrasonic waves, so that standing waves are formed at an actual focus, and the actual focus vibrates under the action of the standing waves to emit secondary sound waves.
The specific form of the detection ultrasonic wave and the treatment ultrasonic wave can be independently selected from pulse ultrasonic wave, continuous ultrasonic wave and the like.
It is to be understood that the above embodiments are merely illustrative of the application of the principles of the present invention, but not in limitation thereof. Various modifications and improvements may be made by those skilled in the art without departing from the spirit and substance of the invention, and are also considered to be within the scope of the invention.
Claims (10)
1. An ultrasonic diagnosis and treatment device is characterized by comprising an ultrasonic emission module, a detection module and a control module; wherein,,
the control module is used for controlling the ultrasonic transmitting module and the detecting module to carry out the following working procedures:
diagnosis stage: the ultrasonic transmitting module respectively transmits detection ultrasonic waves by taking each position in a preset range as a theoretical focus; the detection module receives the secondary sound wave and determines a corresponding property distribution diagram according to the secondary sound wave; the detection ultrasonic energy excites tissue vibration at an actual focus to emit the secondary sound wave, the corresponding property distribution map comprises corresponding properties of all positions in the preset range, and the corresponding property of each position is the property of the tissue determined according to the secondary sound wave when the theoretical focus is at the position;
treatment stage: the ultrasonic transmitting module transmits therapeutic ultrasonic waves by taking the target position as a theoretical focus; the target location is within a predetermined range and the therapeutic ultrasound energy treats tissue.
2. The ultrasonic diagnostic treatment apparatus of claim 1, wherein the treatment phase further comprises, prior to the ultrasonic transmission module emitting the treatment ultrasonic waves with the target location as the theoretical focus:
the control module determines at least one location from the predetermined range as the target location based on the corresponding property profile obtained in the detection stage.
3. The ultrasonic diagnostic treatment apparatus of claim 1, wherein the workflow, after a treatment session, further comprises:
evaluation phase: the ultrasonic transmitting module at least takes the target position as a theoretical focus to transmit the detection ultrasonic wave; the detection module receives the secondary sound wave and at least determines the corresponding property of the target position according to the secondary sound wave.
4. The ultrasonic diagnostic and therapeutic apparatus according to claim 3, wherein the ultrasonic transmission module emits the detection ultrasonic wave with at least a target position as a theoretical focus; the detection module receives the secondary sound wave, and at least determining the corresponding property of the target position according to the secondary sound wave comprises:
the ultrasonic transmitting module respectively transmits the detection ultrasonic waves by taking each position in a preset range as a theoretical focus; and the detection module receives the secondary sound wave and determines a corresponding property distribution diagram according to the secondary sound wave.
5. The ultrasonic diagnostic and therapeutic apparatus according to claim 1, wherein the ultrasonic transmission module emitting the detection ultrasonic waves with each position within a predetermined range as a theoretical focus, respectively, includes:
and the ultrasonic transmitting module sequentially and respectively transmits the detection ultrasonic waves by taking each position in a preset range as a theoretical focus according to a preset scanning path.
6. The ultrasonic diagnostic and therapeutic apparatus according to claim 1, wherein,
the properties of the tissue include mechanical and/or acoustic properties of the tissue.
7. The ultrasonic diagnostic and therapeutic apparatus according to claim 1, wherein,
the power of the detection ultrasonic wave is 1W to 10W;
the power of the therapeutic ultrasonic wave is 20W to 500W.
8. The ultrasonic diagnostic and therapeutic apparatus according to claim 1, wherein,
the frequency of the detection ultrasonic wave is 500kHz to 10MHz;
the therapeutic ultrasound has a frequency of 500kHz to 10MHz.
9. The ultrasonic diagnostic and therapeutic apparatus according to claim 1, wherein,
the detection ultrasonic wave is single-frequency ultrasonic wave or difference-frequency ultrasonic wave.
10. The ultrasonic diagnostic treatment apparatus according to claim 1, wherein said detection ultrasonic wave is used to vibrate tissue at an actual focal point to emit a secondary sound wave by at least one of:
amplitude modulation, beat frequency interference, pulse excitation, standing wave interference.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202211694994.2A CN116115258A (en) | 2022-12-28 | 2022-12-28 | Ultrasonic diagnostic and therapeutic equipment |
| PCT/CN2023/129533 WO2024139721A1 (en) | 2022-12-28 | 2023-11-03 | Ultrasonic diagnosis and treatment device |
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| CN202211694994.2A CN116115258A (en) | 2022-12-28 | 2022-12-28 | Ultrasonic diagnostic and therapeutic equipment |
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| WO (1) | WO2024139721A1 (en) |
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