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CN116058867B - A lightweight imaging ultrasound system with unfixed scanning probe and an ultrasound detection method - Google Patents

A lightweight imaging ultrasound system with unfixed scanning probe and an ultrasound detection method Download PDF

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CN116058867B
CN116058867B CN202310017632.8A CN202310017632A CN116058867B CN 116058867 B CN116058867 B CN 116058867B CN 202310017632 A CN202310017632 A CN 202310017632A CN 116058867 B CN116058867 B CN 116058867B
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CN116058867A (en
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王江涛
齐昊
潘海林
王雪松
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Beijing Changchao Medical Technology Co ltd
East China Normal University
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East China Normal University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4444Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/46Ultrasonic, sonic or infrasonic diagnostic devices with special arrangements for interfacing with the operator or the patient
    • A61B8/461Displaying means of special interest
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48Diagnostic techniques
    • A61B8/483Diagnostic techniques involving the acquisition of a 3D volume of data
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/52Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/5215Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/56Details of data transmission or power supply
    • A61B8/565Details of data transmission or power supply involving data transmission via a network

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Abstract

本发明提出了一种不固定扫描探头的轻量型成像超声系统,所述成像超声系统包括无线扫描探头、终端设备、三维成像计算设备;其中,所述无线扫描探头以无线方式分别向终端设备和三维成像计算设备传输超声图像数据和探头的加速度、角速度数据;所述终端设备向三维成像计算设备提供所需的二维超声图像;所述三维成像计算设备将重建完成的三维超声数据传输至终端设备。本发明解决了医生对二维超声图像难以理解的问题,能够使医生通过实时三维视图更直观地理解组织器官结构,以更高效率的方式培训医生做超声扫描和理解二维超声图,解决超声医生培训耗时长的问题。

The present invention proposes a lightweight imaging ultrasound system without a fixed scanning probe, the imaging ultrasound system includes a wireless scanning probe, a terminal device, and a three-dimensional imaging computing device; wherein the wireless scanning probe transmits ultrasound image data and the acceleration and angular velocity data of the probe to the terminal device and the three-dimensional imaging computing device in a wireless manner respectively; the terminal device provides the required two-dimensional ultrasound image to the three-dimensional imaging computing device; the three-dimensional imaging computing device transmits the reconstructed three-dimensional ultrasound data to the terminal device. The present invention solves the problem that doctors find it difficult to understand two-dimensional ultrasound images, enables doctors to understand tissue and organ structures more intuitively through real-time three-dimensional views, trains doctors to perform ultrasound scanning and understand two-dimensional ultrasound images in a more efficient way, and solves the problem of time-consuming ultrasound doctor training.

Description

Light-weight imaging ultrasonic system without fixed scanning probe and ultrasonic detection method
Technical Field
The invention belongs to the technical field of ultrasound, and relates to a light-weight imaging ultrasound system with an unfixed scanning probe and an ultrasound detection method.
Background
In the medical field, ultrasonic scanning detection is widely used in clinical diagnosis due to its unique advantages. Compared with Computed Tomography (CT) and Magnetic Resonance Imaging (MRI), the ultrasonic imaging technology has the advantages of non-invasive, non-radiative, low cost and the like. In conventional ultrasound examination, a doctor places an ultrasound scanning probe on a patient's body to scan, so as to obtain a two-dimensional image of a cross section of a human tissue organ. In this conventional manner, however, the physician must reconstruct a two-dimensional ultrasound image into the three-dimensional anatomy of the human body in the brain. In order to be able to do this, however, the doctor must be trained professionally, and the training process takes a lot of time and money. Compared with a two-dimensional ultrasonic image, the three-dimensional ultrasonic image can provide the whole volume condition of the region of interest, and a more visual space structure is provided for doctors.
Early three-dimensional reconstruction of ultrasound images can be accomplished in three stages, acquisition, reconstruction, and visualization, respectively. The specific flow is to collect a series of ultrasonic images obtained by ultrasonic scanning of the target position, and to perform visual display through a corresponding three-dimensional reconstruction algorithm. The three-dimensional reconstruction technology separates ultrasonic scanning, volume reconstruction and visualization phases, and belongs to non-real-time three-dimensional image reconstruction. In this reconstruction mode, the probe is typically translated, tilted and rotated by a micro-motor driven mechanism to effect cross-sectional scanning, and a series of two-dimensional ultrasound images of the examination area are acquired slowly and then recorded in a computer. The scanning is performed by a mechanical device for controlling and fixing the probe according to a preset scheme, so that the relative position and angle of each image can be known, but the scanning device is heavy, the scanning mode is inflexible and the like, and the three-dimensional reconstruction can be performed after the scanning, so that the scanning device is not practical clinically.
At present, the real-time three-dimensional reconstruction of a two-dimensional ultrasonic image is realized, and the main technology is that a sensor is added on an ultrasonic probe, then the ultrasonic probe is held by a hand to perform free arm scanning, the sensor transmits the recorded real-time spatial information such as the real-time spatial position of the ultrasonic probe and the scanning direction back to a computer in real time, the computer combines the real-time obtained two-dimensional ultrasonic image with the spatial information of the probe, and then the real-time three-dimensional reconstruction and visualization of the ultrasonic image are performed. The sensor positioning technology mainly includes optical positioning and electromagnetic positioning, for example, an optical positioning instrument is used to measure three-dimensional space position coordinates of an ultrasonic probe, such as a three-dimensional ultrasonic imaging method based on a space positioning device, a storage medium and equipment (patent publication number: CN113081033 a), and an electromagnetic tracking system is also used, that is, an ultrasonic probe with an electromagnetic sensor and an electromagnetic transmitter capable of tracking the position and direction of the electromagnetic sensor are used to perform positioning, such as a hand-held unconstrained scanning wireless three-dimensional ultrasonic real-time voxel imaging system (patent publication number: CN 111184535A). In addition, acoustic positioning technology is used, and the specific method is to fix three acoustic emission devices on an ultrasonic probe, fix a microphone array on a patient, and acquire positioning information through measuring the sound propagation time. Recently, a sensor Kinect with a depth camera is combined with an angle sensor to realize the positioning of an ultrasonic probe, such as a three-dimensional ultrasonic imaging method for reconstructing a two-dimensional ultrasonic image set (patent publication No. CN 107582098A).
Different sensors have different requirements on the applicable scene, so that certain disadvantages exist. The problem found in optical tracking positioning systems is that the markers mounted on the ultrasound probe are too large, resulting in an inconvenient ultrasound scanning process and the view of the camera cannot be blocked. The problem with electromagnetic positioning is that the surrounding ferrous metal can affect the magnetic field, resulting in a bias in position measurement. The problem with acoustic positioning is that the microphone must be placed above the patient so that the sound rays can reach unimpeded, and the distance between the transmitter and the microphone is sufficiently close to ensure that a high signal to noise ratio is achieved, and the speed of sound will vary with changes in air humidity, thus producing a certain error. The problem with the Kinect somatosensory detection device with the depth of field camera is that the requirement on environment and light intensity is higher when outdoor use is adopted, because the influence of strong natural light is easily received outdoors, the projected coded light is submerged, the effect cannot be satisfied, and the influence of smooth plane reflection is easily received. Therefore, the methods have the problems of large volume, wired constraint, incapability of truly freely moving and operating of ultrasonic equipment and the like.
In addition, an inertial navigation system-based three-dimensional ultrasonic reconstruction system (publication number: CN 114533111A) provides a method for ultrasonic three-dimensional reconstruction by using inertial navigation. The mentioned position calculation algorithm is too simple, the accuracy error of position calculation is too large, and because the data of the two-dimensional ultrasonic image and the IMU sensor are data acquired discretely in time, after the data are mapped to the real three-dimensional space, some vacant parts exist in the three-dimensional space, even if the sampling frequency is increased, the vacant parts still exist, so that the reconstruction result is inaccurate. Meanwhile, the method has the defect that the equipment is bound by a cable and cannot move and operate truly freely.
Disclosure of Invention
In order to solve the defects in the prior art, the invention provides a light-weight imaging ultrasonic system without a fixed scanning probe and an ultrasonic detection method.
The invention can guide doctors to scan and read two-dimensional images without difficulty through three-dimensional image reconstruction, namely, the invention can be free from the limitation of a fixed scanning probe of a mechanical arm, is free from the limitation of the abstract and unreadable two-dimensional images, and can obtain the expected optimal two-dimensional images by adopting free arm scanning.
Specifically, the invention realizes real-time three-dimensional reconstruction of a two-dimensional ultrasonic image by installing a wireless inertial measurement unit on a wireless ultrasonic probe and acquiring ultrasonic image data and space information by using the inertial measurement unit and the wireless ultrasonic probe, and finally simultaneously displays the two-dimensional ultrasonic image and the reconstructed three-dimensional ultrasonic image on a screen of a mobile device in real time. Because the two-dimensional ultrasonic image and the corresponding three-dimensional ultrasonic image can be simultaneously displayed on the mobile equipment, the three-dimensional ultrasonic image can more intuitively help doctors to understand the two-dimensional ultrasonic image, the problem that doctors are difficult to understand the two-dimensional ultrasonic image is solved, the doctors can more intuitively understand the tissue organ structure through real-time three-dimensional views, the doctors are trained to do ultrasonic scanning and understand the two-dimensional ultrasonic image in a more efficient mode, and the problem that the training time of the ultrasonic doctors is long is solved.
Secondly, the invention adopts a free scanning mode of the wireless ultrasonic probe to scan the interested part. Therefore, the scanning mode of the imaging system is flexible, light and small, and the problems of fixed/semi-fixed scanning mode and heavy scanning device of the traditional three-dimensional ultrasonic imaging system are solved.
The invention provides a light imaging ultrasonic system with an unfixed scanning probe, which comprises a wireless scanning probe, a terminal device and a three-dimensional imaging computing device, wherein the wireless scanning probe is used for respectively transmitting ultrasonic image data and data such as acceleration, angular speed and the like of the probe to the terminal device and the three-dimensional imaging computing device in a wireless mode, the terminal device is used for providing a required two-dimensional ultrasonic image to the three-dimensional imaging computing device, and the three-dimensional imaging computing device is used for transmitting the reconstructed three-dimensional ultrasonic data to the terminal device.
The wireless scanning probe comprises two modules, namely a wireless ultrasonic probe module and a wireless inertial measurement unit module, and particularly, the wireless scanning probe acquires real-time spatial position information of the probe in the ultrasonic scanning process by installing the wireless inertial measurement unit on the wireless ultrasonic probe. The scanning probe is a wireless ultrasonic probe, and has the advantages of convenient wireless transmission and use, no constraint of cables, and lower power and longer endurance time. The wireless ultrasonic probe module is used for converting the coded and decoded ultrasonic echo signals into JPEG image data and transmitting the image data to the terminal equipment through the USB module or the WIFI module.
The wireless inertial measurement unit is arranged on the wireless ultrasonic probe and consists of a gyroscope and an accelerometer, the accelerometer is used for detecting triaxial acceleration signals of the ultrasonic probe, the gyroscope detects angular velocity signals, and the wireless inertial measurement unit module is used for transmitting three-dimensional attitude data of the probe to the three-dimensional imaging computing equipment through the wireless module. The inertial measurement unit has the advantages that the inertial measurement unit can be used for positioning the data without any external help, and the inertial measurement unit has low requirements on external environment, is not influenced by light and electromagnetic interference, and can even work under water.
The terminal device is a mobile display device provided with ultrasonic imaging software and is used for simultaneously and real-timely visualizing a two-dimensional ultrasonic image obtained by the ultrasonic probe and a three-dimensional ultrasonic image obtained by the three-dimensional imaging computing device. The terminal equipment establishes connection between the two-dimensional ultrasonic image and the three-dimensional imaging computing equipment through a Socket and uses a mobile network to communicate, the two-dimensional ultrasonic image is transmitted to the three-dimensional imaging computing equipment in real time, the three-dimensional imaging computing equipment transmits the three-dimensional ultrasonic image data after reconstruction back to the terminal equipment, and the terminal equipment synchronously displays the two-dimensional ultrasonic image and the three-dimensional ultrasonic image in real time. The terminal equipment is mobile equipment such as a mobile phone or tablet equipment, and has the advantages of small size, light weight and convenient operation.
The three-dimensional imaging computing equipment is a high-performance computer, real-time angular velocity and acceleration data of the ultrasonic probe obtained by the wireless inertial measurement unit in a three-dimensional space are transmitted to the three-dimensional imaging computing equipment through the 433 wireless transparent transmission module, then the three-dimensional imaging computing equipment is used for resolving the data to obtain the gesture of the ultrasonic probe and combining with a two-dimensional ultrasonic image obtained by the terminal equipment in real time to reconstruct three-dimensionally, and meanwhile, the reconstructed three-dimensional ultrasonic image data are transmitted to the terminal equipment.
In order to solve the problem that the existing method has a gap when pixel-to-voxel mapping is performed after the position resolving precision is poor and resolving, the invention provides a complete set of position resolving algorithm and three-dimensional reconstruction interpolation algorithm.
The three-dimensional imaging computing device carries out the principle of resolving the gesture and the position according to the data of the inertial measurement unit as follows:
Two coordinate systems are involved in the pose and position resolving process, one is the IMU (Inertial Measurement Unit) own coordinate system b and the other is the finally reconstructed reference coordinate system R, so that the information output by the IMU needs to be converted into the reference system through resolving.
The IMU comprises a triaxial accelerometer for measuring the change of triaxial acceleration during movement and a triaxial gyroscope for measuring the change of triaxial angular velocity.
(1) Three-axis gesture solution
The IMU outputs direction information in the form of quaternions. The general form of a quaternion is a scalar q 0 (angle of rotation), followed by a vector q (axis of rotation), q= (q 1,q2,q3)
The quaternion is similar to the complex number, and is formed by adding three imaginary units to a real numberComposition, and they have the following relationship: Each quaternion is 1, Is a linear combination of (a) and (b). For the followingThe geometrical meaning of itself is understood as a rotation, whereinRotation represents positive rotation of the Z-axis in the positive direction of the Y-axis in the plane of intersection of the Z-axis and the Y-axis,Rotation represents positive rotation of the X-axis in the positive direction of the Z-axis in the plane of intersection of the X-axis and the Z-axis,The rotation represents a positive rotation of the Y-axis in the positive direction of the X-axis in a plane where the Y-axis intersects the X-axis.
As shown in fig. 1, given an axis of rotation defined by a vectorThe quaternion may represent a rotation of rotation angle θ about this axis u:
thus an operation that converts vector v into a square rotation about the u-axis and with a rotation angle θ can be represented by a square of the quaternion, expressed as:
Wherein q *=q0 -q is a conjugated quaternion of q.
The pose of the motion system b (the coordinate system of the ultrasound probe with IMU) with respect to the reference system R (the coordinate system of the final three-dimensional reconstruction) is completely determinable by both the rotation axis u and the rotation angle θ. A pose quaternion can be constructed with two parameters, u and θ:
the formula shows that the reference coordinate system R rotates around u by an angle theta and then coincides with the motion coordinate system b, so that the gesture of the motion coordinate system b can pass through the gesture quaternion Transformed into a pose in the reference frame R, the coordinate transformation formula is:
After the initial posture information is given, the posture quaternion recursion can be performed in real time to convert the rotation posture information of the IMU self coordinate system b into the rotation posture information of the reference coordinate system R, and the recursion formula of the posture quaternion is as follows:
wherein t represents the moment, and t starts from 0, so that the attitude quaternion of the current moment can be recursively derived from the attitude information of the previous moment, and the attitude information of the IMU at each moment can be further calculated.
(2) Solution of displacement
The triaxial accelerometer in the IMU can obtain the triaxial acceleration value at the current moment, but the acceleration of the earth gravity and the Ge-type acceleration generated by the earth rotation need to be compensated, and the acceleration is integrated to obtain the speed, namely the speed v k at the k moment can be obtained by the speed at the k-1 moment, the integration of the acceleration and an error compensation term:
Wherein Deltav g/cor(k) represents the influence of local gravitational acceleration and Ge acceleration at time k, and can be calculated by using the local latitude, the earth rotation angular velocity and the output of the IMU gyroscope, alpha (tau) is the output of the IMU accelerometer, The gesture transformation matrix can be obtained by converting gesture quaternions obtained by the first step of calculation,Representing the transformation of the acceleration output of the IMU from its own coordinate system b to the reference coordinate system R, the subscript k representing time.
(3) Positioning
The position P k at the k time can be obtained by integrating and accumulating the speeds:
(4) Complete flow
Firstly, giving initial gesture, position and speed information of the IMU, then moving the ultrasonic probe with the IMU, and carrying out real-time recursion by combining gesture calculation and displacement calculation along with time, so that the real-time position of the current ultrasonic probe can be obtained, and the final positioning is completed. The invention is different from the simple integral of IMU data in the existing method, because the gesture and the position of the current ultrasonic probe are solved by dynamically recursively in real time through gesture quaternion, and the influence of earth gravity and autorotation on IMU output is considered, the precision of the solved gesture and position is higher.
The invention also provides an ultrasonic detection method using the imaging ultrasonic system, which comprises the following steps:
The method comprises the steps of firstly, acquiring data by moving and rotating a wireless scanning probe, wherein the data comprise ultrasonic data of a region to be detected, acceleration, angular velocity and other information measured by an inertial measurement unit;
step two, transmitting the ultrasonic data acquired by the wireless scanning probe to terminal equipment;
step three, the terminal equipment performs visualization of the two-dimensional ultrasonic image according to the ultrasonic data, and transmits the two-dimensional ultrasonic image to a three-dimensional imaging computing platform;
Transmitting the information such as acceleration, angular velocity and the like obtained by measurement to a three-dimensional imaging calculation platform by an inertia measurement unit;
and fifthly, carrying out three-dimensional reconstruction by the three-dimensional imaging computing platform according to the two-dimensional ultrasonic image obtained in the step three and the information such as acceleration, angular velocity and the like obtained in the step four in combination with an interpolation algorithm, transmitting three-dimensional ultrasonic image data to terminal equipment for visualization if the reconstruction is completed, ending ultrasonic detection, and returning to the step one for carrying out the subsequent steps again if the reconstruction is not completed.
The interpolation algorithm and visualization in the three-dimensional reconstruction process are described as follows:
(1) Interpolation algorithm
In the fifth step, the three-dimensional computing device synchronizes the two-dimensional ultrasound image with the information output by the IMU according to the timestamp information, then calculates the position of each frame of two-dimensional ultrasound image in the three-dimensional space according to the foregoing resolving process, and then completes the final three-dimensional reconstruction by using the interpolation algorithm for the empty voxels which are not mapped in the three-dimensional space.
The method finally uses voxels to represent the three-dimensional ultrasonic data after reconstruction, wherein the voxels are cube blocks with fixed sizes in the three-dimensional space, are the minimum units which are most used for representing the three-dimensional data, and correspond to pixels in the two-dimensional image. The two-dimensional ultrasonic image is a gray level image, each pixel has a determined gray level value, and the interpolation algorithm assigns the gray level value of the pixel in the two-dimensional ultrasonic image to a corresponding voxel through a certain strategy according to the positioning information.
The interpolation algorithm of the three-dimensional reconstruction method adopts a square distance weighting algorithm to complete interpolation, and the specific algorithm is described as follows:
Where I (V T) is the gray value of the target voxel, n is the number of pixels falling within a predefined sphere region centered at V T, I (P i) represents the gray value of the I-th pixel within the region, W i is the weight of the I-th pixel, inversely proportional to the square of the distance d to the sphere voxel V T, d being obtainable by a previous position solution. All voxels may ultimately be assigned a value by traversing each voxel. The schematic diagram of the algorithm is shown in fig. 2, and fig. 2 maps the three-dimensional space onto a two-dimensional plane, wherein the small square represents voxels in the three-dimensional space, the gray circular region represents a predefined sphere region, the straight line passing through the voxels represents a two-dimensional ultrasonic image, and the black dots on the straight line represent pixels.
(2) Visualization of
The three-dimensional computing equipment communicates with the terminal equipment through a Socket and a mobile network, and transmits the reconstructed three-dimensional voxel data to the terminal equipment in real time, the terminal equipment stores the data by using a buffer queue, performs volume drawing through a ray projection algorithm, finally renders the three-dimensional voxel data in real time, and simultaneously displays the three-dimensional voxel data and a two-dimensional ultrasonic image on a screen in a picture-in-picture mode.
The invention has the beneficial effects that the invention provides the wireless scanning probe with unfixed and high flexibility, and the wireless scanning probe is formed by installing the wireless inertial measurement unit on the wireless ultrasonic probe. The wireless ultrasonic probe has the advantages that the host and the probe are of an integrated lightweight design, the probe is small and exquisite and convenient to hold, the wireless ultrasonic probe is not limited by wires, and the images are transmitted in real time. The wireless inertial measurement unit is used for positioning, so that the measurement data can be obtained only by using the internal sensor without any external help, and in addition, the inertial measurement unit has lower requirements on external environment, is not influenced by light and electromagnetic interference, and can even work under water. The two-dimensional ultrasonic image and the three-dimensional ultrasonic image after reconstruction are displayed on the portable mobile device (such as a smart phone or a tablet computer) in real time, and the ultrasonic image displayed by the mobile device has the advantages of small size and convenience in carrying and carrying. The invention can carry out three-dimensional reconstruction of the ultrasonic image in real time during ultrasonic scanning, which solves the problems of low efficiency and long time consumption in the three-dimensional reconstruction process in the prior art. The wireless ultrasonic probe used by the invention integrates a host, the ultrasonic probe can directly encode and decode ultrasonic echo signals into JPEG image data, compared with the traditional ultrasonic equipment, the volume of the equipment is greatly reduced, the built-in WIFI module of the probe can transmit the image data to the terminal equipment in a wireless mode, and a sensor adopted for acquiring the three-dimensional posture of the probe is an inertial measurement unit, so that the real-time acceleration and the angular speed of the wireless probe can be transmitted to the three-dimensional computing platform in a wireless mode. The invention greatly improves the efficiency of three-dimensional reconstruction of the ultrasonic image, further can help doctors to understand the two-dimensional image by using the three-dimensional view in real time, and can solve the problems that the doctors are difficult to correctly scan and understand the two-dimensional ultrasonic image when training the ultrasonic doctors.
Drawings
FIG. 1 is a schematic representation of the rotation axis transformation in resolving gestures in accordance with the present invention.
Fig. 2 is a schematic diagram of an interpolation algorithm used in the present invention.
Fig. 3 is a system block diagram of an imaging ultrasound system of the present invention with a scanning probe free.
Fig. 4 is a block diagram of an ultrasonic probe and an inertial measurement unit used in the present invention.
Fig. 5 is an internal structural view of a wireless scanning probe with an inertial measurement unit of the present invention.
FIG. 6 is a flow chart of an ultrasonic detection method of the present invention.
Detailed Description
The present invention will be described in further detail with reference to the following specific examples and drawings. The procedures, conditions, experimental methods, etc. for carrying out the present invention are common knowledge and common knowledge in the art, except for the following specific references, and the present invention is not particularly limited.
The invention provides a light-weight imaging ultrasonic system with an unfixed scanning probe and an ultrasonic detection method, which are characterized in that ultrasonic original data are processed through a wireless ultrasonic probe and converted into image coding data, the image coding data are transmitted to terminal equipment for display, the terminal equipment transmits the obtained image data to a three-dimensional computing platform, a wireless inertial measurement unit in the probe transmits probe posture data obtained in real time to the three-dimensional computing platform, the three-dimensional computing platform utilizes all received data to reconstruct an ultrasonic image in a three-dimensional manner, the reconstructed three-dimensional data are finally transmitted to the terminal equipment, and the terminal equipment simultaneously displays a two-dimensional ultrasonic image and a three-dimensional ultrasonic image.
The system structure diagram of the invention is shown in figure 3, and consists of a wireless scanning probe, a terminal device and a three-dimensional imaging computing device. The external and internal structures of the wireless scanning probe are shown in fig. 4 and 5, and the wireless scanning probe consists of a wireless ultrasonic probe and a wireless inertial measurement unit, wherein a wireless 433 transparent transmission module is integrated in the wireless inertial measurement unit, and the wireless inertial measurement unit and the wireless ultrasonic probe work together with a battery in the wireless ultrasonic probe.
The specific flow of the ultrasonic detection method of the present invention is shown in fig. 6, and is specifically described as follows:
Step 1, scanning the interested human organ tissue by using a wireless ultrasonic probe provided with a sensor to collect ultrasonic signals. The scanning mode is to hold the ultrasonic probe, and the probe can be freely rotated and translated to repeatedly scan the interested part.
And 2, acquiring spatial information through a sensor arranged outside the wireless ultrasonic probe, wherein the selected sensor is an inertial measurement unit, the inertial measurement unit can transmit acceleration and angular velocity information of the wireless ultrasonic probe in the moving and rotating processes to the three-dimensional imaging computing equipment, and the data transmission mode is that the data are transmitted through a 433 wireless transparent transmission module.
And 3, transmitting the collected ultrasonic signals in the scanning process to the terminal equipment in real time by the wireless ultrasonic probe, wherein the transmission mode of the ultrasonic data is to transmit the ultrasonic signals through WIFI.
And 4, reconstructing an ultrasonic signal obtained from the ultrasonic probe into a two-dimensional ultrasonic image by the terminal equipment (a mobile phone or a tablet) in real time and visualizing the two-dimensional ultrasonic image at the terminal equipment.
And 5, transmitting the two-dimensional ultrasonic image to the three-dimensional imaging computing equipment through the mobile network in real time by the terminal equipment.
And 6, the three-dimensional imaging computing equipment calculates the acceleration and angular velocity information obtained by the inertial measurement unit to obtain the coordinate position of the ultrasonic probe in the three-dimensional space, and then reconstructs the three-dimensional ultrasonic image in real time by combining the two-dimensional ultrasonic image obtained in real time from the terminal equipment with the space information obtained by settlement.
And 7, transmitting the reconstructed three-dimensional ultrasonic image data to the terminal equipment when the three-dimensional imaging computing equipment passes through a network, and simultaneously visualizing the real-time two-dimensional ultrasonic image and the three-dimensional ultrasonic image by the terminal equipment to form contrast.
In this example, a wireless ultrasound probe is used in step 1. As shown in fig. 5, the two large scale integrated circuits a are controlled by 1 large scale integrated circuit B to perform the functions of transmitting high voltage pulses to and receiving echoes from an ultrasonic probe (the lowest 128 array elements of the ultrasonic probe). The two large-scale integrated circuits A are used for transmitting high-voltage driving pulses to the ultrasonic probe and receiving sound wave signals reflected by the probe, each large-scale integrated circuit A is used for respectively transmitting the high-voltage driving pulses to half of array elements and receiving the sound wave signals reflected by the probe, the transmitting and receiving functions are controlled and switched by the large-scale integrated circuit B, and the large-scale integrated circuit B is provided with at least 64 physical channels to finish analog front-end amplification and analog-to-digital conversion. The digital signal is converted into a brightness signal, the brightness signal is converted into JPEG through an internal coder and decoder, then the JPEG is transmitted to the WIFI module through the synchronous serial bus, and finally the digital signal is wirelessly transmitted to the terminal equipment through the WIFI module, so that the real-time performance of wireless transmission is realized and ensured. Meanwhile, the system also has a wired transmission function, and if the data is not transmitted by adopting WIFI, the large-scale integrated circuit B can also transmit the JPEG data to the terminal equipment in real time in a wired mode through USB.
In this example, the scanning mode of the wireless ultrasonic probe in step 1 is a free scanning mode that is not fixed, including a translation and a rotation ultrasonic probe, the translation wireless ultrasonic probe can detect longitudinal sections of different positions in the three-dimensional space of the target, the detected information can not be further increased only by the translation mode, the rotation ultrasonic sensor can detect the three-dimensional space of the target from different angles, and the translation and rotation movement modes are combined to detect the three-dimensional imaging area.
In this example, the sensor used in step 2 to detect the spatial position of the wireless ultrasonic probe uses an inertial measurement unit, and its main components include a gyroscope and an accelerometer, where the accelerometer is used to detect the three-axis acceleration signal of the wireless ultrasonic probe, and the gyroscope detects the angular velocity signal. The inertial measurement unit has the advantages that the inertial measurement unit can be used for positioning the data without any external help, and the inertial measurement unit has low requirements on external environment, is not influenced by light and electromagnetic interference, can work underwater, and is suitable for more application scenes. As shown in fig. 5, the inertial measurement unit is connected with the 433 wireless transparent transmission module by using an asynchronous serial bus, the inertial measurement unit transmits measured data to the 433 wireless transparent transmission module in real time through the asynchronous serial bus, and then the 433 wireless module transmits the data to the three-dimensional imaging computing device through a 433MHz wireless frequency band.
In this example, the three-dimensional imaging computing device in step 2 is a high-performance computer, and is capable of receiving two-dimensional ultrasound image data from the terminal device and data from the inertial measurement unit, performing three-dimensional reconstruction on the obtained data through a three-dimensional reconstruction algorithm, and finally transmitting the three-dimensional reconstruction to the terminal device through a mobile network.
In this example, in step 3, the terminal device is a mobile device such as a mobile phone or a tablet computer, and the wireless ultrasonic probe transmits the acquired ultrasound to the terminal device through a wireless transmission protocol, and the terminal device visualizes the ultrasound two-dimensional image and the ultrasound three-dimensional image.
The protection of the present invention is not limited to the above embodiments. Variations and advantages that would occur to one skilled in the art are included within the invention without departing from the spirit and scope of the inventive concept, and the scope of the invention is defined by the appended claims.

Claims (7)

1.一种不固定扫描探头的轻量型成像超声系统,其特征在于,所述成像超声系统包括无线扫描探头、终端设备、三维成像计算设备;其中,1. A lightweight imaging ultrasound system without a fixed scanning probe, characterized in that the imaging ultrasound system includes a wireless scanning probe, a terminal device, and a three-dimensional imaging computing device; wherein: 所述无线扫描探头以无线方式分别向终端设备和三维成像计算设备传输超声图像数据和探头的加速度、角速度数据;The wireless scanning probe transmits the ultrasonic image data and the acceleration and angular velocity data of the probe to the terminal device and the three-dimensional imaging computing device in a wireless manner respectively; 所述终端设备向三维成像计算设备提供所需的二维超声图像;The terminal device provides the required two-dimensional ultrasound image to the three-dimensional imaging calculation device; 所述三维成像计算设备将重建完成的三维超声数据传输至终端设备;所述三维成像计算设备进行姿态和位置的解算方法为:The three-dimensional imaging computing device transmits the reconstructed three-dimensional ultrasound data to the terminal device; the three-dimensional imaging computing device performs posture and position calculation method as follows: 在姿态和位置解算过程中涉及到两个坐标系,一个是IMU自身的坐标系b,一个是最终重建的参考系R,将IMU输出的信息通过解算转换到参考系中:There are two coordinate systems involved in the attitude and position calculation process. One is the IMU's own coordinate system b, and the other is the final reconstructed reference system R. The information output by the IMU is converted to the reference system through calculation: IMU包含三轴加速度计和三轴陀螺仪,加速度计用来测量运动过程中三轴加速度的变化,陀螺仪用来测量三轴角速度的变化;IMU contains a three-axis accelerometer and a three-axis gyroscope. The accelerometer is used to measure the changes in three-axis acceleration during movement, and the gyroscope is used to measure the changes in three-axis angular velocity; (1)三轴姿态的解算(1) Calculation of three-axis attitude IMU以四元数的形式输出方向信息;四元数的一般形式是一个旋转的角度标量q0,后跟一个旋转的轴矢量q,q=(q1,q2,q3):The IMU outputs orientation information in the form of quaternions; the general form of a quaternion is a rotation angle scalar q 0 followed by a rotation axis vector q, q = (q 1 ,q 2 ,q 3 ): 其中,每个四元数都是1、的线性组合;对于本身的几何意义理解为一种旋转,其中旋转代表Z轴与Y轴相交平面中Z轴正向向Y轴正向的旋转,旋转代表X轴与Z轴相交平面中X轴正向向Z轴正向的旋转,旋转代表Y轴与X轴相交平面中Y轴正向向X轴正向的旋转;in, Every quaternion is 1. A linear combination of The geometric meaning of itself is understood as a rotation, in which The rotation represents the rotation from the positive direction of the Z axis to the positive direction of the Y axis in the plane where the Z axis and the Y axis intersect. The rotation represents the rotation from the positive direction of the X axis to the positive direction of the Z axis in the plane where the X axis and the Z axis intersect. The rotation represents the rotation from the positive direction of the Y axis to the positive direction of the X axis in the plane where the Y axis and the X axis intersect; 给定由矢量定义的旋转轴四元数表示绕该轴u旋转角度为θ的旋转:Given an axis of rotation defined by a vector The quaternion represents a rotation around the axis u with an angle θ: 将一个将向量v转变为绕u轴的正方的旋转且旋转角度为θ的操作由四元数的连乘表示,公式表为:An operation that transforms vector v into a square rotation around the u axis with a rotation angle of θ is represented by the multiplication of quaternions, and the formula is: 其中,q*=q0-q,是q的共轭四元数;Wherein, q * =q 0 -q, is the conjugate quaternion of q; 坐标系b相对于参考系R的姿态由旋转轴u和转动角度θ两个参数来确定;用u和θ两个参数构造一个姿态四元数:The attitude of coordinate system b relative to reference system R is determined by two parameters: rotation axis u and rotation angle θ. Use u and θ to construct an attitude quaternion: 上述公式表示参考坐标系R绕u转动一个角度θ后与运动坐标系b重合,坐标系b的姿态通过姿态四元数变换为在参考系R中的姿态,坐标变换公式为:The above formula indicates that the reference coordinate system R rotates around u by an angle θ and coincides with the moving coordinate system b. The attitude of the coordinate system b is expressed by the attitude quaternion Transformed into the posture in the reference system R, the coordinate transformation formula is: 在给定初始姿态信息后,实时进行姿态四元数的递推将IMU自身坐标系b的旋转姿态信息转化为参考系R的旋转姿态信息,姿态四元数的递推公式如下:After the initial attitude information is given, the attitude quaternion is recursively deduced in real time to convert the rotation attitude information of the IMU's own coordinate system b into the rotation attitude information of the reference system R. The recursive formula of the attitude quaternion is as follows: 其中,t代表时刻,t从0开始,当前时刻的姿态四元数由前一时刻的姿态信息递推得出,进一步计算出每时每刻IMU的姿态信息;Among them, t represents the time, t starts from 0, the attitude quaternion of the current moment is recursively derived from the attitude information of the previous moment, and the attitude information of the IMU at each moment is further calculated; (2)位移的解算(2) Calculation of displacement 当前时刻三轴的加速度值通过IMU的中的三轴加速度计,补偿地球重力加速度和地球自转产生的哥式加速度,通过对加速度进行积分得到速度,即k时刻的速度vk由k-1时刻的速度、加速度的积分以及误差补偿项得到:The three-axis acceleration value at the current moment is compensated for the earth's gravity acceleration and the Coriolis acceleration caused by the earth's rotation by the three-axis accelerometer in the IMU. The velocity is obtained by integrating the acceleration, that is, the velocity vk at time k is obtained by the velocity at time k-1, the integral of the acceleration and the error compensation term: 其中,Δvg/cor(k)表示k时刻当地重力加速度和哥式加速度的影响,利用当地纬度、地球自转角速度以及IMU陀螺仪的输出计算得出,α(τ)是IMU加速度计的输出,是姿态变换矩阵利用第一步计算得到的姿态四元数转化得到,表示将IMU的加速度输出从坐标系b变换到参考系R,下标k代表时间;Where Δv g/cor(k) represents the effect of local gravity and Coriolis acceleration at time k, which is calculated using the local latitude, the Earth's rotation angular velocity, and the output of the IMU gyroscope. α(τ) is the output of the IMU accelerometer. The attitude transformation matrix is obtained by transforming the attitude quaternion calculated in the first step. It means transforming the acceleration output of IMU from coordinate system b to reference system R, and the subscript k represents time; (3)定位(3) Positioning 在对速度进行积分和累加,得到k时刻的位置PkBy integrating and accumulating the velocity, we can get the position P k at time k: 2.如权利要求1所述的不固定扫描探头的轻量型成像超声系统,其特征在于,所述无线扫描探头包括无线超声探头模块和无线惯性测量单元模块;其中,2. The lightweight imaging ultrasound system with a non-fixed scanning probe as claimed in claim 1, wherein the wireless scanning probe comprises a wireless ultrasound probe module and a wireless inertial measurement unit module; wherein: 通过在无线超声探头模块上安装无线惯性测量单元模块来获取超声扫描过程中探头的实时空间位置信息;The real-time spatial position information of the probe during the ultrasonic scanning process is obtained by installing a wireless inertial measurement unit module on the wireless ultrasonic probe module; 所述无线超声探头模块扫描用的探头为无线超声探头,无线超声探头模块将编解码超声回波信号为图像数据,并将图像数据传输至终端设备;The probe used for scanning by the wireless ultrasonic probe module is a wireless ultrasonic probe, and the wireless ultrasonic probe module encodes and decodes the ultrasonic echo signal into image data, and transmits the image data to the terminal device; 所述无线惯性测量单元模块由陀螺仪和加速度计组成,加速度计用来检测无线超声探头的三轴加速度信号,陀螺仪则检测角速度信号;The wireless inertial measurement unit module is composed of a gyroscope and an accelerometer, the accelerometer is used to detect the three-axis acceleration signal of the wireless ultrasonic probe, and the gyroscope detects the angular velocity signal; 所述无线惯性测量单元模块将无线超声探头的三维姿态数据通过无线模块传输至三维成像计算设备。The wireless inertial measurement unit module transmits the three-dimensional posture data of the wireless ultrasonic probe to the three-dimensional imaging calculation device through the wireless module. 3.如权利要求1所述的不固定扫描探头的轻量型成像超声系统,其特征在于,所述终端设备为安装有超声成像软件的移动显示设备,用来同时以及实时的可视化超声探头得到的二维超声图像和由三维成像计算设备得到的三维超声图像;3. The lightweight imaging ultrasound system with a non-fixed scanning probe as claimed in claim 1, wherein the terminal device is a mobile display device installed with ultrasound imaging software, which is used to simultaneously and in real time visualize the two-dimensional ultrasound image obtained by the ultrasound probe and the three-dimensional ultrasound image obtained by the three-dimensional imaging computing device; 所述终端设备将二维的超声图像通过Socket与三维成像计算设备建立连接并使用移动网络进行通信,实时的将二维超声图像传输给三维成像计算设备,三维成像计算设备再将重构完成的三维超声图像数据传输回终端设备,由终端设备实时同步显示二维超声图像和三维超声图像。The terminal device establishes a connection between the two-dimensional ultrasound image and the three-dimensional imaging computing device through the Socket and uses the mobile network to communicate, and transmits the two-dimensional ultrasound image to the three-dimensional imaging computing device in real time. The three-dimensional imaging computing device then transmits the reconstructed three-dimensional ultrasound image data back to the terminal device, and the terminal device synchronously displays the two-dimensional ultrasound image and the three-dimensional ultrasound image in real time. 4.如权利要求1所述的不固定扫描探头的轻量型成像超声系统,其特征在于,所述无线扫描探头获得的超声探头在三维空间中的数据通过无线透传模块传输给三维成像计算设备,然后由三维成像计算设备将数据解算得到无线扫描探头的姿态并结合终端设备实时获得的二维超声图像进行三维重建,同时将重建后的三维超声图像数据传输至终端设备。4. The lightweight imaging ultrasound system with a non-fixed scanning probe as described in claim 1 is characterized in that the data of the ultrasound probe in three-dimensional space obtained by the wireless scanning probe is transmitted to a three-dimensional imaging calculation device through a wireless transparent transmission module, and then the three-dimensional imaging calculation device solves the data to obtain the posture of the wireless scanning probe and combines it with the two-dimensional ultrasound image obtained in real time by the terminal device to perform three-dimensional reconstruction, and at the same time transmits the reconstructed three-dimensional ultrasound image data to the terminal device. 5.一种利用如权利要求1-4之任一项所述的不固定扫描探头的轻量型成像超声系统的超声检测方法,其特征在于,包括如下步骤:5. An ultrasonic detection method using a lightweight imaging ultrasonic system with a non-fixed scanning probe as claimed in any one of claims 1 to 4, characterized in that it comprises the following steps: 步骤一、通过移动和旋转无线扫描探头采集数据;所述数据包括待检测区域的超声数据以及惯性测量单元测定的加速度、角速度信息;Step 1: Collect data by moving and rotating the wireless scanning probe; the data includes ultrasonic data of the area to be detected and acceleration and angular velocity information measured by the inertial measurement unit; 步骤二、将无线扫描探头采集获得的超声数据传输到终端设备中;Step 2: Transmitting the ultrasonic data collected by the wireless scanning probe to the terminal device; 步骤三、终端设备根据超声数据进行二维超声图像的可视化,并将二维超声图像传输至三维成像计算平台;Step 3: The terminal device visualizes the two-dimensional ultrasound image according to the ultrasound data, and transmits the two-dimensional ultrasound image to the three-dimensional imaging computing platform; 步骤四、惯性测量单元将测定获得的加速度、角速度信息传输到三维成像计算平台中;Step 4: The inertial measurement unit transmits the measured acceleration and angular velocity information to the three-dimensional imaging computing platform; 步骤五、三维成像计算平台根据步骤三获得的二维超声图像和步骤四获得的加速度、角速度信息结合插值算法进行三维重建;若重建完成,则三维成像计算平台将三维超声图像数据传输至终端设备进行可视化,超声检测结束;若重建未完成,则回到步骤一重新进行后续步骤。Step 5: The three-dimensional imaging computing platform performs three-dimensional reconstruction based on the two-dimensional ultrasound image obtained in step 3 and the acceleration and angular velocity information obtained in step 4 in combination with the interpolation algorithm; if the reconstruction is complete, the three-dimensional imaging computing platform transmits the three-dimensional ultrasound image data to the terminal device for visualization, and the ultrasound detection is completed; if the reconstruction is not complete, return to step 1 and perform the subsequent steps again. 6.如权利要求5所述的超声检测方法,其特征在于,三维重建过程中插值算法包括:6. The ultrasonic detection method according to claim 5, characterized in that the interpolation algorithm in the three-dimensional reconstruction process includes: 在步骤五中,三维计算设备首先根据时间戳信息将二维超声图像和IMU输出的信息进行同步,然后根据解算过程去计算每一帧二维超声图像在三维空间中的位置,对三维空间中没有被映射的空缺体素再利用插值算法完成最终的三维重建;In step 5, the 3D computing device first synchronizes the 2D ultrasound image and the information output by the IMU according to the timestamp information, and then calculates the position of each frame of the 2D ultrasound image in the 3D space according to the solution process, and uses the interpolation algorithm to complete the final 3D reconstruction for the vacant voxels that are not mapped in the 3D space; 用体素表示重建完成的三维超声数据;二维超声图像是灰度图,插值算法根据定位信息将二维超声图像中像素的灰度值通过策略赋值给相应的体素;The reconstructed 3D ultrasound data is represented by voxels; the 2D ultrasound image is a grayscale image, and the interpolation algorithm assigns the grayscale value of the pixel in the 2D ultrasound image to the corresponding voxel through a strategy based on the positioning information; 所述插值算法采用平方距离加权算法完成插值,具体算法描述如下:The interpolation algorithm uses a square distance weighted algorithm to complete the interpolation. The specific algorithm is described as follows: 其中,I(VT)是目标体素的灰度值,n是指落在预定义的以VT为球心的球体区域内的像素数,I(Pi)代表该区域内第i个像素的灰度值,Wi是第i个像素的权重,与到球心体素VT的距离d的平方成反比,d是通过之前的位置解算求得的;通过遍历每一个体素最终将所有体素赋值;将三维空间映射到了二维平面上,其中的小方格代表三维空间中的体素,灰色圆形区域代表预先定义好的球体区域,穿过体素的直线代表二维超声图像,直线上的黑点代表像素。Among them, I( VT ) is the grayscale value of the target voxel, n refers to the number of pixels falling within the predefined spherical area with VT as the center, I( Pi ) represents the grayscale value of the i-th pixel in the area, Wi is the weight of the i-th pixel, which is inversely proportional to the square of the distance d to the spherical center voxel VT , and d is obtained by the previous position solution; by traversing each voxel, all voxels are finally assigned values; the three-dimensional space is mapped to the two-dimensional plane, in which the small squares represent the voxels in the three-dimensional space, the gray circular area represents the pre-defined spherical area, the straight line passing through the voxels represents the two-dimensional ultrasound image, and the black dots on the straight line represent pixels. 7.如权利要求5所述的超声检测方法,其特征在于,三维重建过程中可视化包括:7. The ultrasonic detection method according to claim 5, wherein the visualization in the three-dimensional reconstruction process comprises: 三维计算设备通过Socket和移动网络与终端设备进行通信,并实时的将重构完成的三维体素数据传输到终端设备上,终端设备使用缓存队列来存放此数据,并通过光线投射算法进行体绘制,最终将三维体素数据实时的渲染出来,并以画中画的形式与二维超声图像在屏幕上同时显示。The 3D computing device communicates with the terminal device through Socket and mobile network, and transmits the reconstructed 3D voxel data to the terminal device in real time. The terminal device uses a cache queue to store this data and performs volume rendering through a ray casting algorithm. Finally, the 3D voxel data is rendered in real time and displayed on the screen simultaneously with the 2D ultrasound image in the form of picture-in-picture.
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