CN1160354A - Fragrance composition and its use in particular in pharmaceuticals, cosmetics, fragrances or health products - Google Patents
Fragrance composition and its use in particular in pharmaceuticals, cosmetics, fragrances or health products Download PDFInfo
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- CN1160354A CN1160354A CN95195632A CN95195632A CN1160354A CN 1160354 A CN1160354 A CN 1160354A CN 95195632 A CN95195632 A CN 95195632A CN 95195632 A CN95195632 A CN 95195632A CN 1160354 A CN1160354 A CN 1160354A
- Authority
- CN
- China
- Prior art keywords
- olibanum
- quintessence oil
- eucalyptole
- weight
- borneolum syntheticum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 title claims abstract description 78
- 239000003205 fragrance Substances 0.000 title claims abstract description 15
- 239000003814 drug Substances 0.000 title claims description 14
- 239000002537 cosmetic Substances 0.000 title claims description 13
- 230000036541 health Effects 0.000 title claims description 6
- 150000001875 compounds Chemical class 0.000 claims abstract description 14
- 229910052751 metal Inorganic materials 0.000 claims abstract description 12
- 239000002184 metal Substances 0.000 claims abstract description 10
- 150000003751 zinc Chemical class 0.000 claims abstract description 4
- 239000003921 oil Substances 0.000 claims description 112
- 239000004863 Frankincense Substances 0.000 claims description 97
- 241000717739 Boswellia sacra Species 0.000 claims description 95
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 52
- 229960005233 cineole Drugs 0.000 claims description 48
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 claims description 44
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 37
- 125000003118 aryl group Chemical group 0.000 claims description 17
- 238000002360 preparation method Methods 0.000 claims description 17
- 235000013599 spices Nutrition 0.000 claims description 14
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 13
- 239000000126 substance Substances 0.000 claims description 13
- 241000196324 Embryophyta Species 0.000 claims description 10
- 239000003960 organic solvent Substances 0.000 claims description 8
- 239000010949 copper Substances 0.000 claims description 7
- 239000000645 desinfectant Substances 0.000 claims description 7
- 239000011701 zinc Substances 0.000 claims description 7
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 6
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 6
- 229910052802 copper Inorganic materials 0.000 claims description 6
- 229910052725 zinc Inorganic materials 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 5
- 150000001768 cations Chemical class 0.000 claims description 4
- 150000002739 metals Chemical class 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract description 5
- 239000008158 vegetable oil Substances 0.000 abstract description 5
- 239000000341 volatile oil Substances 0.000 abstract description 5
- 229920000175 Pistacia lentiscus Polymers 0.000 abstract 3
- 150000001491 aromatic compounds Chemical class 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 150000001879 copper Chemical class 0.000 abstract 1
- 235000019198 oils Nutrition 0.000 description 104
- 230000000694 effects Effects 0.000 description 14
- 238000007254 oxidation reaction Methods 0.000 description 12
- 239000000047 product Substances 0.000 description 12
- 230000003647 oxidation Effects 0.000 description 11
- 239000000243 solution Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 239000007788 liquid Substances 0.000 description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 238000009792 diffusion process Methods 0.000 description 6
- 239000002917 insecticide Substances 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 238000000746 purification Methods 0.000 description 6
- 239000011347 resin Substances 0.000 description 6
- 229920005989 resin Polymers 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- 230000002159 abnormal effect Effects 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 239000000546 pharmaceutical excipient Substances 0.000 description 5
- 238000001556 precipitation Methods 0.000 description 5
- 230000035943 smell Effects 0.000 description 5
- 150000003505 terpenes Chemical class 0.000 description 5
- 235000007586 terpenes Nutrition 0.000 description 5
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- 230000000996 additive effect Effects 0.000 description 4
- 239000002269 analeptic agent Substances 0.000 description 4
- 230000003555 analeptic effect Effects 0.000 description 4
- 230000002421 anti-septic effect Effects 0.000 description 4
- 238000004821 distillation Methods 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000008601 oleoresin Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 230000001430 anti-depressive effect Effects 0.000 description 3
- 239000000935 antidepressant agent Substances 0.000 description 3
- 229940005513 antidepressants Drugs 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 239000002781 deodorant agent Substances 0.000 description 3
- -1 deodorizer Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 239000005871 repellent Substances 0.000 description 3
- 230000002940 repellent Effects 0.000 description 3
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 3
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 2
- 235000018062 Boswellia Nutrition 0.000 description 2
- 240000007551 Boswellia serrata Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- 229940090898 Desensitizer Drugs 0.000 description 2
- 240000005636 Dryobalanops aromatica Species 0.000 description 2
- 244000166124 Eucalyptus globulus Species 0.000 description 2
- 235000005205 Pinus Nutrition 0.000 description 2
- 241000218602 Pinus <genus> Species 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 2
- 230000002924 anti-infective effect Effects 0.000 description 2
- 230000002141 anti-parasite Effects 0.000 description 2
- 239000003096 antiparasitic agent Substances 0.000 description 2
- UAHWPYUMFXYFJY-UHFFFAOYSA-N beta-myrcene Chemical compound CC(C)=CCCC(=C)C=C UAHWPYUMFXYFJY-UHFFFAOYSA-N 0.000 description 2
- 229940025250 camphora Drugs 0.000 description 2
- 239000010238 camphora Substances 0.000 description 2
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000001256 steam distillation Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000011885 synergistic combination Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000011592 zinc chloride Substances 0.000 description 2
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 description 1
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 description 1
- DCSCXTJOXBUFGB-JGVFFNPUSA-N (R)-(+)-Verbenone Natural products CC1=CC(=O)[C@@H]2C(C)(C)[C@H]1C2 DCSCXTJOXBUFGB-JGVFFNPUSA-N 0.000 description 1
- DCSCXTJOXBUFGB-SFYZADRCSA-N (R)-(+)-verbenone Chemical compound CC1=CC(=O)[C@H]2C(C)(C)[C@@H]1C2 DCSCXTJOXBUFGB-SFYZADRCSA-N 0.000 description 1
- 125000002006 1,8-cineol group Chemical group 0.000 description 1
- NBGQZFQREPIKMG-UHFFFAOYSA-N 3beta-hydroxy-beta-boswellic acid Natural products C1CC(O)C(C)(C(O)=O)C2CCC3(C)C4(C)CCC5(C)CCC(C)C(C)C5C4=CCC3C21C NBGQZFQREPIKMG-UHFFFAOYSA-N 0.000 description 1
- 241000379194 Abies sibirica Species 0.000 description 1
- 241001608538 Boswellia Species 0.000 description 1
- 241001033456 Boswellia frereana Species 0.000 description 1
- 235000004216 Boswellia frereana Nutrition 0.000 description 1
- 241000877494 Boswellia papyrifera Species 0.000 description 1
- 235000003717 Boswellia sacra Nutrition 0.000 description 1
- 235000012035 Boswellia serrata Nutrition 0.000 description 1
- NBGQZFQREPIKMG-PONOSELZSA-N Boswellic acid Chemical compound C1C[C@@H](O)[C@](C)(C(O)=O)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C NBGQZFQREPIKMG-PONOSELZSA-N 0.000 description 1
- 241000208229 Burseraceae Species 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 239000005973 Carvone Substances 0.000 description 1
- 238000006681 Combes synthesis reaction Methods 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- 240000000991 Eucalyptus amygdalina Species 0.000 description 1
- 235000004692 Eucalyptus globulus Nutrition 0.000 description 1
- 240000004476 Eucalyptus polybractea Species 0.000 description 1
- 235000009683 Eucalyptus polybractea Nutrition 0.000 description 1
- 235000005230 Eucalyptus salicifolia Nutrition 0.000 description 1
- 244000196003 Eucalyptus smithii Species 0.000 description 1
- 235000005262 Eucalyptus smithii Nutrition 0.000 description 1
- 241000534594 Leucadendron Species 0.000 description 1
- 241000121629 Majorana Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- 239000008896 Opium Substances 0.000 description 1
- 241000922366 Socotra Species 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 240000003021 Tsuga heterophylla Species 0.000 description 1
- KGEKLUUHTZCSIP-HOSYDEDBSA-N [(1s,4s,6r)-1,7,7-trimethyl-6-bicyclo[2.2.1]heptanyl] acetate Chemical compound C1C[C@]2(C)[C@H](OC(=O)C)C[C@H]1C2(C)C KGEKLUUHTZCSIP-HOSYDEDBSA-N 0.000 description 1
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 210000004404 adrenal cortex Anatomy 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- BZXULBWGROURAF-UHFFFAOYSA-N alpha-boswellic acid Natural products C1CC(O)C(C)(C(O)=O)C2CCC3(C)C4(C)CCC5(C)CCC(C)(C)CC5C4=CCC3C21C BZXULBWGROURAF-UHFFFAOYSA-N 0.000 description 1
- VYBREYKSZAROCT-UHFFFAOYSA-N alpha-myrcene Natural products CC(=C)CCCC(=C)C=C VYBREYKSZAROCT-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229930006722 beta-pinene Natural products 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- RBNWAMSGVWEHFP-UHFFFAOYSA-N cis-p-Menthan-1,8-diol Natural products CC(C)(O)C1CCC(C)(O)CC1 RBNWAMSGVWEHFP-UHFFFAOYSA-N 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 description 1
- OPQARKPSCNTWTJ-UHFFFAOYSA-L copper(ii) acetate Chemical compound [Cu+2].CC([O-])=O.CC([O-])=O OPQARKPSCNTWTJ-UHFFFAOYSA-L 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000004332 deodorization Methods 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000000586 desensitisation Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 235000008633 elephant tree Nutrition 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 239000010642 eucalyptus oil Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 229940043259 farnesol Drugs 0.000 description 1
- 229930002886 farnesol Natural products 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000004508 fractional distillation Methods 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hcl hcl Chemical compound Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 239000000346 nonvolatile oil Substances 0.000 description 1
- YLYBTZIQSIBWLI-UHFFFAOYSA-N octyl acetate Chemical compound CCCCCCCCOC(C)=O YLYBTZIQSIBWLI-UHFFFAOYSA-N 0.000 description 1
- 229960001027 opium Drugs 0.000 description 1
- 229930006948 p-menthane-3,8-diol Natural products 0.000 description 1
- 230000000590 parasiticidal effect Effects 0.000 description 1
- 239000002297 parasiticide Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000010773 plant oil Substances 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- RBNWAMSGVWEHFP-WAAGHKOSSA-N terpin Chemical compound CC(C)(O)[C@H]1CC[C@@](C)(O)CC1 RBNWAMSGVWEHFP-WAAGHKOSSA-N 0.000 description 1
- 229950010257 terpin Drugs 0.000 description 1
- 238000005979 thermal decomposition reaction Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229940125725 tranquilizer Drugs 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 description 1
- DCSCXTJOXBUFGB-UHFFFAOYSA-N verbenone Natural products CC1=CC(=O)C2C(C)(C)C1C2 DCSCXTJOXBUFGB-UHFFFAOYSA-N 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 239000004246 zinc acetate Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- WTARULDDTDQWMU-UHFFFAOYSA-N β-pinene Chemical compound C1C2C(C)(C)C1CCC2=C WTARULDDTDQWMU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Fats And Perfumes (AREA)
- Cosmetics (AREA)
Abstract
The invention relates in particular to aromatic compounds in essential oils or vegetable oils. To meet this object, among others, the present invention relates to a fragrance composition comprising, on the one hand, at least one active fragrance system based on mastic gum, consisting of at least one essential oil of mastic gum and/or of one or more constituents of mastic gum, and, on the other hand, at least one active fragrance system chosen from those of formula C10H18An O compound and/or a metal synergist selected from copper salts and zinc salts.
Description
The present invention relates to the aromatic in quintessence oil or vegetable oil particularly.
Clearly, the basic function of these chemical compounds is to discharge tangible, pleasant taste and abnormal smells from the patient, and result wherein some chemical compound very naturally, very popularly is used for to food or cosmetics perfuming.But these chemical compounds may also have effect treatment, antiseptical, disinfectant, deodorant even parasiticide and insecticide/insecticide repellent, and these effects perhaps are applied in industrial goods and commodity.
Or rather, the objective of the invention is a kind of fragrant composition, it is the fragrant active component of key component with the Olibanum that this compositions contains at least a, and its Olibanum is that the component by at least a Olibanum quintessence oil or one or more this oil constitutes.
The invention still further relates to the purposes of said composition in preparation medicine, health care product, sanitizer, deodorizer, antiseptic, insecticide, insecticide repellent, antiparasitic, plant quarantine agent, cosmetics or spice aspect.
The Olibanum quintessence oil extracts from olive subject plant.The country of origin of these plants is African northeast, Arab and Iranian basically, and these plants provide a kind of natural gum-oleo-resins, and it contains sugar, pure and mild acid.Usually, this quintessence oil obtains by this natural gum-oleo-resins of steam distillation.Its distillation is made up of a kind of thick liquid, because of the source and the purification process that may stand, this thick liquid can be colourless, dark yellow, light yellow, with red yellow.
This Olibanum is because its pleasant fragrance diffusion character and obtain certainly using, and particularly emits these perfume (or spice) and abnormal smells from the patient fragrance under the effect of heat.People also know the treatment application of Olibanum quintessence oil:
-inside and outside use treatment infection symptoms,
-adopt interior oral administration to be used as antidepressant,
-as production analeptic and the main component that contains the face cream medicine,
-add contain in the opium cyanoglosse ball, in the mercurous plaster or in anti-some neuralgic active ingredient.
Its pleasant aromatic character makes it be used in the spice commodity natch.
But industry and business development Olibanum quintessence oil or their aromatised fraction are still extremely limited to careful.In fact the major applications of medicine, cosmetic or spice commodity is further developed.
Thisly passed into disuse multiple reason, this will study below.
At first, the defective of Olibanum quintessence oil is to be difficult to dissolving in medicine or the normally used organic solvent of spice commodity.This seriously hinders operation and the convenient adding of multi-form Olibanum quintessence oil in various preparations.
External or interior when in addition, the direct result of this dissolubility defective is the treatment use with all being difficult to diffusion.The bioavailability that this means the Olibanum active component is not maximum, and the thing followed is that these therapeutic efficacies are affected.
The second, Olibanum oil has the bad trend of degraded when aging, and particularly this oil is subjected to harsh environmental factors effect: all the more so when air, light and heat.This shows Oxidation and " resinification ", and promptly its viscosity increases, and this only makes the operation of this oil and use become complicated.Consider the treatment studied, fragrance, deodorant, disinfectant effect etc., the signs of degradation that this signs of degradation, particularly Oxidation cause is followed and is generated undesirable by-product.
The 3rd, it should be apparent that, the fragrant composition of Olibanum type improve its treatment, can obtain industry and commercial benefit when deodorant, disinfectant functional character etc.From this viewpoint, because of tangible economic cause, Miao Zhun purpose is to increase its activity at last, reduces its dosage simultaneously.
In this case, it is the fragrant composition of key component with the Olibanum reactive compound that one of main purpose of the present invention provides a kind of, this compositions has dissolubility and stability good when concrete as aging, meet more and use simply the physical-chemical property of the industrial technology index that period of storage is long.
It is the fragrant composition of key component with Olibanum or analog that another object of the present invention provides a kind of, and it specifically is the character of medicine, cosmetic, spice or hygienic function that this compositions has, and its active dose is the smaller the better under the functional character optimum condition.
Another object of the present invention provides a kind of effectively economic raw material that not only constitutes, and usually in multiple application easily and the fragrant composition that can in general manner use.
In order to satisfy these purposes, applicant's contribution is unexpectedly proof after through big quantity research and test, divides C with Olibanum reactive compound and at least a chemical formula that is selected from
10H
18The synergist combination of O chemical compound and/or its slaine is suitable.
So, the present invention relates to a kind of fragrant composition, this compositions contains, on the one hand at least a is key component with the Olibanum, by the quintessence oil of at least a Olibanum and/or the active aroma system that constitutes by one or more Olibanum components, on the other hand, at least a chemical formula C that is selected from
10H
18The synergist of O chemical compound and/or its period of element classification chart IB family and IIB family slaine (" LaChimie-Dictionnaire encyclopedique-Jacques Angenault-EditionsDUNOD-1991), zinc and copper are particularly preferred metals.
The advantage and the benefit of this compositions are that it is the physicochemical properties and the functional character of the aroma system of key component with the Olibanum that the potentiating compounds fragrance of this particular chemical class and/or metal has strengthened.This is in particular in:
-effect potentiation,
-dissolubility preferably in organic solvent, especially at ethanol and all the more so in aromatised fraction,
-diffusion preferably,
-bigger stability when aging.
The combination of this original creation has specific industry and commercial significance for any from the fragrant plant product of Olibanum.
The present invention is special, and the Olibanum quintessence oil of selecting extracts from the Burseraceae little tree; Preferably: Boswellia carterii-birdw and contiguous kind.These little trees mainly are grown in Iran, India, the Africa and Arabic between the Red sea and the Indian Ocean.This one side in Africa, this angle that relates to Africa, Ethiopia, Somalia, Socotra and island, Eritrea, here found Boswelliacarterii-birdwood, Boswellia frereana birdwood (or female Olibanum) and Boswelliabhau-dajiana birdwood (male Olibanum).Le Boswellia papyrifera (Del.) Hochst is grown in the Sudan and island, Eritrea.In Arab, find Boswellia sacra flueckiger.In India, find Boswellia serrata Ro.Above-named and the contribution applicant is that any boswellia of isolation and selection provides a kind of natural gum-oleo-resins, and it contains sugar, acid, alcohol, quintessence oil.
According to unique design of the present invention and advantage,, and, the component of Olibanum quintessence oil is divided into groups again (Higazy, Obermann, Peyron etc.) with the percentage composition that the place of production changes according to the chemical constitution of Olibanum.
-hydrocarbon: australene (, being up to 40%), nopinene, limonene, myrcene from key component in the Olibanum quintessence oil of Aden
-alcohol: olibanol, Borneolum Syntheticum, farnesol, capryl alcohol, incensol (erythree)
-ether: 1, the 8-eucalyptole
-carbonyl compound: carvone, verbenone
-α and β boswellic acid
-ester: Caprylyl acetate (key component: erythree is up to more than 50%).
The Borneolum Syntheticum of nascent state or the Borneolum Syntheticum of esterification, and eucalyptole ratio in the Olibanum quintessence oil is low, average out to 1% more or less in Aden and erythree.
The olfactory unit that natural gum-resin-Olibanum is arranged and extract product.
Many technologies may be used to extract the component of olibanoresin, for example with water vapour, volatile solvent, thermal decomposition product distillation.
According to the present invention, these three kinds of technology are desirable, but this gummy oleo-resins of steam distillation is desirable especially.Its distillation is made up of a kind of thick liquid, because of the source and the processing that may stand, this thick liquid can be colourless, dark yellow, light yellow, with red yellow.The density of this Olibanum quintessence oil is about 0.850-1060.This oil because of its by resinification, or become heavier owing to being resin-like.
According to a preferred feature of the present invention, synergist contains eucalyptole, Borneolum Syntheticum (form natural or that be ester) or their mixture to the small part aroma properties.These two kinds of chemical compounds are C
10H
18The O isomer, they exist in a large number, and are also not too expensive comparatively speaking.
Generally be referred to as 1,8-eucalyptole or 1, the 8-epoxy is a kind of inner oxide ether corresponding to terpin to the eucalyptole of alkane.It can extract from each vegetable oil, is liquid form.Certainly contain a large amount of (promptly being up to 85%) Eucalyptus oils.As an example, wherein can enumerate: Eucalyptus globulus, Eucalyptus austrialana, Eucalyptus amygdalina, Eucalyptus polybractea and Eucalyptus smithii.
Can also mention Malaleuca leucadendron and Malaleuca viridiflora, they contain the eucalyptole of 60-75% and 35-70% respectively.For the ease of memory, point out Artemisa cina and Artemisa vulgaris at last.
Eucalyptole is a kind of flowable colourless liquid, and its abnormal smells from the patient has the abnormal smells from the patient of Herba Menthae and Camphora simultaneously, and its density is 0.921.Known eucalyptole pharmacologically active is efficient expectorant and antiseptic.This eucalyptole often is used as the infection means of breathing apparatus, particularly urogenital equipment.
Also relate to application as disinfectant, deodorizer, antiparasitic, insecticide/insecticide repellent.
Effective eucalyptole as synergist can be pure form in the present invention, or with the quintessence oil carrier band that is rich in eucalyptole, for example uses one or more above-mentioned quintessence oil carrier bands.
About Borneolum Syntheticum, can mention a kind of alcohol that obtains by tree: Dryobalanops Camphora in Borneo and Sumatra growth.This Borneolum Syntheticum (straight Borneolum Syntheticum) is known as 1,7,7-trimethyl dicyclo [2.2.1] heptane-2-alcohol, and it reclaims with crystal form from Dryobalanops Camphora bark.
Borneolum Syntheticum is dissolved in ethanol and the mobile vegetable oil.Its density is lower than the density of water.Each vegetable oil all contains this or is pure state, perhaps is the Borneolum Syntheticum of the form of ester.As an illustration, the oil in these Borneolum Syntheticum sources, can enumerate:
-Rosmarinus Officinalis (15% weight)
-pinaster quintessence oil, especially:
★ Abies sibirica[40% (weight) borneol acetate],
★Tsuga?canadensis，
★Pinus?silvestris，
★ Pinus mariana etc.
The mixture of-Origanum majorana[85% (weight) Camphora and " Bruylants " Borneolum Syntheticum],
-Thymus satureoides[35% (weight)].
This Borneolum Syntheticum is a kind of antiseptic, is a kind of general analeptics for many other Borneolum Syntheticums, especially a kind of adrenal cortex analeptic.It is used for the treatment of and catches and depressed attitude disease, or uses as desensitizer.
In the mode same with eucalyptole, be that the synergist of key component can be undertaken by one or more quintessence oils to add Borneolum Syntheticum at fragrant composition of the present invention, specifically be those quintessence oils as mentioned above, they are rich in this active aromatic.
Owing to will obtain fragrant composition of the present invention, especially may use all or part of Olibanum quintessence oil, and the quintessence oil that contains eucalyptole and/or Borneolum Syntheticum, what be worth spelling out is that these plant oil compositions may change, many factors are depended in described variation.At first, be obviously, these oily plant origins have determined the polytropy relevant with the geographical position, and its weather and soil property are depended in this polytropy.In addition, the variation of composition may change with the plant harvest time.At last, be clear that the distillation mode is other factors that the quintessence oil that obtains is at last more or less influenced.
Consider these, should be noted that in fact first factor is not critical, possible is other two factors of control, so that guarantee the stable of the stable in properties of these quintessence oils, particularly physicochemical properties, therapeutic properties and cosmetic character.
Should consider that also the quintessence oil that uses in the fragrant composition of the present invention can be the form of rectification or not have the form of rectification.
So in the present invention, term " rectification " means one or more purification process, remove one or more unwanted components in the quintessence oil by purification process.Particularly, these terpenes that in fact all exist in all quintessence oils can be removed by removing the terpenes effect.A kind of like this processing intent is to improve the dissolubility of this oil in ethanol, and improves its fragrant performance.More specifically, this relates to the spice commodity.Self-evident, the purification of this oil or rectification also may extend to other components in the quintessence oil except that these terpenes, i.e. alkaloid or other non-terpenes components.
These purification/rectification process can be removed these unwanted components according to desired application.These unwanted chemical compounds can all or part ofly be removed.
Constitute by at least a Olibanum quintessence oil at the reactive systems that with the Olibanum is key component, synergist contains under the situation of eucalyptole, the amount of eucalyptole, the highest in total composition is 15-75% (volume), preferably 25-35% (volume).
Conversely, when the active aroma system that with the Olibanum is key component is made of at least a Olibanum quintessence oil, when its synergist contains Borneolum Syntheticum, the amount of its Borneolum Syntheticum, with respect to the reactive systems that with the Olibanum is key component is 5-100% (weight), 20-30% preferably, more preferably about 25% (weight).
Advantageously, this compositions contains at least a organic solvent that is selected from fat, alcohol, ether or their mixture, preferably is selected from alcohol/or the organic solvent of ether, more preferably ethanol.
Favourable embodiment according to the present invention, described synergist contains at least a slaine, in the gross weight of the aromatic that constitutes fragrant object, the amount of one or more metal cations is 0.1-10% (weight), preferably 0.1-5% (weight).
Preferably, this synergist contains at least a zinc salt and/or at least a mantoquita.
Come from its cation under the situation of copper, in the gross weight of aromatic (or aromatic substance), the concentration of copper [with % (weight) expression] is 0.3-1%, preferably 0.4-0.6% advantageously.
Come from its cation under the situation of zinc, in the gross weight of aromatic (or aromatic substance), zinc concentration [with % (weight) expression] is 0.1-2%, preferably 0.5-2% advantageously.
It on the one hand is key component and on the other hand with eucalyptole and/or Borneolum Syntheticum with the Olibanum, perhaps Zn salt and/or Cu salt are this synergistic combination of the system of key component, and its advantageous effect is to improve the dissolubility of chemical compound in organic solvent (for example ethanol) of Olibanum.Particularly, the Olibanum quintessence oil has just proved this point, and this oil is the rectification form or is not the rectification form, no matter how the mode of operation of extracting is not always the case.
Also prove, compare with the fragrant composition that only is key component with the Olibanum, this compositions can diffuse through different solid carriers better, as the animal or plant tissue, fibrous material (when its compositions is liquid state or gaseous state) and by gas (when its compositions is steam-like) as air and so on.
This good diffusion is a bioavailability, therapeutic effect just, the root of the sterilization of spice commodity, cosmetics, surrounding air or the better performance of deodorization.
Also may observe, above-mentioned synergistic combination causes stable character to keep good especially.
The present invention can implement according to different embodiments.
-a according to the embodiment of first kind of embodiment, mixes rectification or unrectified Olibanum quintessence oil with pure (or pure substantially) synergist of eucalyptole and/or Borneolum Syntheticum type.For example can have:
-30% (volume) Olibanum quintessence oil (rectification or not rectification);
-70% (volume) eucalyptole; Or:
-75% (weight) Olibanum quintessence oil (rectification or not rectification);
-25% (weight) Borneolum Syntheticum, or:
-30% (volume) Olibanum quintessence oil (rectification or not rectification);
-70% (volume) eucalyptole;
-25% (weight) Borneolum Syntheticum, this is a benchmark in the Olibanum quintessence oil.
-b-, embodiment according to second kind of embodiment, its compositions can be made up of the blend of essential oils that constitutes primary activity component excipient of the present invention, that is: the chemical compound of Olibanum and with eucalyptole and/or Borneolum Syntheticum with may at least a slaine be the synergist of key component.At figure in this case, the ratio with above-mentioned is identical naturally for the ratio of primary activity component of the present invention (Olibanum and synergist).In fact, for example this can be rectification or unrectified Olibanum quintessence oil, be rich in the rectification of eucalyptole and/or Borneolum Syntheticum or the mixture of unrectified quintessence oil (preferably above-mentioned quintessence oil).About being rich in the quintessence oil of Borneolum Syntheticum, can be selected from the quintessence oil that contains the naturalness Borneolum Syntheticum.Yet, to compare with the Borneolum Syntheticum that is ester-formin, the Borneolum Syntheticum of naturalness has good especially solute effect, and on the contrary, its performance that is the Borneolum Syntheticum of ester-formin is developable aspect curative properties.
So, might regulate the Borneolum Syntheticum of naturalness and the content separately of ester Borneolum Syntheticum according to the last application that requires:
+ in first kind of embodiment, the compositions that is rich in the ester-formin Borneolum Syntheticum has the therapeutic properties of being beneficial to (synergism),
+ in second kind of embodiment, the amount that increases the nature Borneolum Syntheticum can be utilized dissolution properties (spice commodity),
+ in the third embodiment, can be with these two kinds of character.
-c unless this is not restrictive and as the embodiment of the 3rd embodiment, can also mention a kind of alternate way, selects the component of one or more Olibanum quintessence oils according to this way, wherein as the pure and mild acid of olibanol.Thereby, can utilize fractional distillation and other purification process, these methods produce removes the terpenes effect, consequently limits the amount of these components, improve the ratio of acid and alcohol or a kind of preferred ingredient, for example in the Olibanum oil of erythree, be the capryl alcohol or as the ester-formin of acetic acid suffering fat and so on of initial condition.
In a kind of like this alternative method, advantageously with the component of one or more Olibanum quintessence oils, perhaps eucalyptole, perhaps eucalyptole and Borneolum Syntheticum (being pure form or one or more quintessence oil forms) mixture combines.
This or these components are a kind of 5-60% of composition weight (weight) preferably, and this compositions contains one or more components and eucalyptole, and its concentration is that 15% (weight) is particularly preferred.
Fortunately, the synergist of combination is an eucalyptole; But therefore this do not get rid of eucalyptole/Borneolum Syntheticum mixture.Under the situation of these mixture, the concentration of Borneolum Syntheticum is that benchmark is 10-50% (weight) in the mixture of the Olibanum component of eucalyptole and one or more selections, preferably 25% (weight).This corresponding to, for example:
-Borneolum Syntheticum (25% (weight) of x) perhaps
Because:
. total Olibanum oil is resin-like than it in as the organic solvent of ethanol and so on easier to be molten,
. the resin-like Olibanum oil is tending towards disperseing with the oil of rectification, can consider to use non-rectification with the total Olibanum quintessence oil of resin-like, to determine maximum dissolubility.This can improve the therapeutic properties of this compositions.
On the contrary, especially for the spice commodity, it is possible using rectification and the Olibanum quintessence oil non-resin shape, for improve diffusion and stability and in organic solvent dissolubility preferably, it is made up with Borneolum Syntheticum and/or eucalyptole is possible.
In the scope of the embodiment that the present invention who mentions is favourable, utilize at least a slaine in the above, can strengthen one or more components active of active and/or this same quintessence oil of Olibanum quintessence oil and they and Borneolum Syntheticum with (or) compounding power of eucalyptole.Preferred metal is zinc and copper.They appear in the pharmacopeia as neural system (neuralgia, epilepsy, spasm) tranquilizer and antiseptic.They have the same therapeutic purposes of these aromatised fractions that can make up with it.Further, they therefore with these aromatised fraction co-action.Its originality for example is a kind of (or two kinds) metal by the inorganic salt as zinc chloride or copper chloride and so on, or combines as the organic salt of zinc acetate or copper acetate and so on.The percent of one or more metal elements, with Olibanum quintessence oil or one or more and Borneolum Syntheticum and (or) the aromatic substance weight that constitutes of the component of eucalyptole combination counts 0.1-10%.The percent of zinc is 0.5-2% (weight) preferably, more preferably 1.4% (weight).The percent of elemental copper is 0.3-1% (weight) preferably, more preferably 0.5% (weight).
In fact, according to this embodiment, two kinds of metals and aromatic substance are combined.The percent of two kinds of metals (metallic element) sum is preferably lower than or equals 2% (weight) aromatic substance.
So the Olibanum quintessence oil can and be the effect that solid-state slaine plays excipient or middle excipient by the dilution Borneolum Syntheticum; Its integral body becomes stable product.
The present invention with the component of Olibanum quintessence oil or one or more Olibanum quintessence oils and eucalyptole and (or) Borneolum Syntheticum and a kind of zinc salt and (or) compositions that combines of a kind of mantoquita, can pure state, perhaps use with additive fragrance or non-drug, cosmetics or hygienic article additive.In this case, different compositionss have complementary effect.
In fact, when for example carrying out Comprehensive Treatment, carry out independent seance ratio and repeatedly treat preferably.In this case, multiple compositions is in same solution, or multiple compositions joins in the same Galenic formula form.The radiopharmacy that the present invention is related to, they wish to combine with the fragrance or the non-aromatic drug product that maybe will have that have had, and described compositions can be added has in the same preparation of described medicine.Producing cosmetics and hygienic article is like this equally.
Be with or without additive the present composition can with excipient, fat preferably, more preferably ether and alcohol, ethanol are preferred, and various preparation and medicine use together.
Advantageously, can add component a kind of at least other fragrance or non-fragrance in the present composition.
According to other aspect in these aspects, the objective of the invention is to use above-mentioned composition, be particularly useful for preparation and depend on the circumstances for oral administration or topical drug (for example anti-infective, antiseptical, medicine antidepressant, excited, desensitization), health product and hygienic article, disinfectant, deodorizer, cosmetics, spice or plant quarantine agent.
For example the present invention relates to following material at last as new product:
+ medicine (for example anti-infective, antiseptical, antidepressant, desensitizer, analeptic),
+ spice,
+ cosmetics,
+ health product and hygienic article (deodorizer, disinfectant), these all contain described fragrant composition.
The present invention can be understood better by following embodiment, and all these advantages and these nonrestrictive different embodiments can be drawn.Embodiment:
Embodiment 1-4: dissolubility
☆ at room temperature stirs 5 minutes (preferably, heating the back a little at pipe) following No. 1 preparations of preparation in embodiment 1:
-a-Olibanum quintessence oil (the Arabic place of production) 100 grams
Dissolved Borneolum Syntheticum 50 grams of-b-
20cm
3Alcohol (ethanol) is at 70 ℃ of dissolving 1cm
3No. 1 preparation, and the quintessence oil of same amount (a-is comprised in 1cm
3In No. 1 preparation) use 20cm
3Ethanol does not dissolve under 70 ℃.
☆ prepares following No. 2 preparations in similarly to Example 1 mode in embodiment 2:
The Olibanum quintessence oil of-c-rectification (the Iranian place of production) 100 grams
-d-Borneolum Syntheticum 50 grams
40cm
3Alcohol is at 70 ℃ of dissolving 1cm
3No. 2 preparations with embodiment 1 observed coming to the same thing, do not have the oil-c-of Borneolum Syntheticum not dissolve in ethanol.
Usually, this Borneolum Syntheticum makes Olibanum quintessence oil rectification or unrectified have dissolubility preferably, no matter the source of its oil how.
☆ is in embodiment 3, to prepare following No. 3 preparations (by volume) with embodiment 1 and 2 same modes:
-e-Olibanum quintessence oil (the Arabic place of production) 30%
-f-eucalyptole 70%
10 volume of ethanol have been dissolved preparation No. 3 at 60 ℃.
For only using quintessence oil, dissolved this preparation at 60 ℃ of 80 times of alcoholic acid volumes.
No matter the source of Olibanum quintessence oil how, no matter rectification of Olibanum quintessence oil or not rectification, eucalyptole all dissolves the Olibanum quintessence oil significantly.
Eucalyptole has improved the dissolubility of Olibanum quintessence oil in ethanol.
☆ prepares following No. 4 preparations in embodiment 4:
-g-provides Olibanum quintessence oil (the Arabic place of production) by the MANE laboratory
95,/01,973 1 milliliters of lot numbers
0.6 milliliter of the ethanol of-h-90% medicinal
Obtain muddy mixture after the stirring.
Can access colored a little clear solution 4.1 add 10 microlitre eucalyptoles (French drugmaker, lot number A25565) in batches.The eucalyptole total amount that adds is 30 microlitres, promptly in Olibanum oil consumption 3% (volume).
4.2, in starting mixt, add Borneolum Syntheticum (Laboratoire deCOMBE d ' Ase, lot number HB11) according to a kind of embodiment, after adding 5 milligrams of Borneolum Syntheticums, cause starting mixt to become clear, after adding 8 milligrams of Borneolum Syntheticums, should dissolve (clear solution) fully by oil.
4.3, at room temperature, in starting mixt, add the olibanoresin (Laboratoire de COMBE d ' Ase, lot number HE02) that is fritter wood shavings shape according to another kind of scheme.Add 10 milligrams of resins and can not eliminate the turbidity of starting mixt, still, can reach dissolving fully in about 40 ℃ of heating.This mixture is muddy again behind cool to room temperature.This mixture thins out after adding 10 milligrams of resins again, and very mild heat can obtain a kind of solution.At this moment this solution at room temperature be still transparent.The result adds 1 milliliter of quintessence oil of 20 milligrams of resin dissolves.
Embodiment 5: the Oxidation of three test mixtures that contains the dissolved Olibanum quintessence oil of embodiment 4
In 48 hours processes of then 4 three tests 4.1,4.2 and 4.3 of embodiment, open the bottle that the dissolving mixt that obtains is housed, allow its mixture contact with air.Can observe, last, contain 1 milliliter of Olibanum quintessence oil, 0.6 milliliter of 90% ethanol and obtain unoxidized clear solution by the mixture of the synergist of eucalyptole (test 4.1), Borneolum Syntheticum (test 4.2) and olibanoresin (test 4.3) formation.Therefore, confirmed that the Oxidation of these mixture does not disturb its solution, the dissolution that relates in particular to the Olibanum quintessence oil is all the more so.The bright difference of MNR stave of these mixture is very little before and after oxidation.
Embodiment 6: the preparation of the Olibanum essential oil composition of the fragrance and the synergist of metalline is arranged
Be prepared as follows compositions:
As implement to enumerate the embodiment of this embodiment:
This compositions of 1 gram-Olibanum quintessence oil 30% (volume)
Aromatic substance (aromatic molecules)=-eucalyptole 70% (volume)
-Borneolum Syntheticum 25% (weight) is a benchmark in the Olibanum quintessence oil
-zinc chloride 0.030 gram
-copper chloride 0.015 gram
Embodiment 7: stability
About stability, should be understood to the constant uniformity (not generating precipitation) of fluid composition here.In order to understand this point, allow hydrochloric acid (HCl) and the effect of Olibanum quintessence oil.Caused like this-oxidation, the color that this oxidation causes this oil by red stain to dark brown, and specific abnormal smells from the patient.Highly oxidized component and chloride component have generated precipitation.
Its testing program is as follows:
-with 1/20cm
3The HCl aqueous solution is pressed 1cm three times
3In the Olibanum quintessence oil.The stirred for several second and a few minutes of leaving standstill.Then this aqueous solution is separated with the oxidation quintessence oil of supernatant.Aqueous solution is the redness same with the oxidation quintessence oil, because this solution contains the product of oxidation and chloride product.The oxidation quintessence oil that reclaims produces more precipitation owing to it is resin.
In test, allow Borneolum Syntheticum or eucalyptole and Olibanum quintessence oil make up and cause its resolution of precipitate with hydrochloric acid (HCl).
Explanation
It seems that eucalyptole and Borneolum Syntheticum make the Olibanum quintessence oil stable owing to dissolve component, oxidation product and the catabolite of Olibanum quintessence oil.
When this compositions contains some non-rectification oil, and during other essential oil component (aromatic additive) except that the Olibanum quintessence oil, by Borneolum Syntheticum and eucalyptole, Olibanum quintessence oil catabolite is dissolved in alcoholic acid phenomenon and is confirmed equally.
Embodiment 8: diffusibility
An eucalyptole can produce a speckle on a piece of paper, the very fast expansion of this speckle, and evaporation is not left a trace.
An Olibanum quintessence oil produces a speckle, and this speckle slowly increases, and leaves a trace to be fixed oil.As if with respect to other oil, the characteristic of Olibanum quintessence oil works here.This speckle is because the Olibanum quintessence oil is resin-like and slower expansion; At this moment this oil generates precipitation, this speckle of its sedimentary surface ratio surperficial little.
Repeat above-mentioned test in the presence of eucalyptole, see that the diffusion of Olibanum quintessence oil is faster, for same resin quintessence oil, its precipitation surface is bigger.
This eucalyptole plays a part excipient.This is important, and is special all the more so for the application of interior usefulness and external curing.
Claims (10)
1, fragrant composition, wherein contain:
On the one hand at least a is key component with the Olibanum, by the quintessence oil of at least a Olibanum and/or the active aroma system that constitutes by the component of one or more Olibanums,
On the other hand, at least a chemical formula C that is selected from
10H
18The synergist of O chemical compound and/or its period of element classification chart IB family and IIB family slaine (" La Chimie-Dictionnaireencyclopedique-Jacques Angenault-EditionsDUNOD-1991), zinc and copper are particularly preferred metals.
2, fragrant composition according to claim 1 is characterized in that its synergist is an aromatic portion at least, also contains eucalyptole, Borneolum Syntheticum or their mixture.
3, fragrant composition according to claim 1 and 2 is characterized in that its synergist adds by at least a quintessence oil, and this quintessence oil is rich in synergist, and described quintessence oil is rectification form or non-rectification form.
4, according to the described fragrant composition of arbitrary claim among the claim 1-3, it is characterized in that with the Olibanum being that the active aroma system of key component is made of at least a Olibanum quintessence oil, its feature is that also its synergist comprises eucalyptole, the amount of eucalyptole, in the total composition is that benchmark is 15-75% (volume), preferably 25-35% (volume).
5, according to the described fragrant composition of arbitrary claim among the claim 1-4, it is characterized in that with the Olibanum being that the active aroma system of key component is made of at least a Olibanum quintessence oil, its feature is that also its synergist comprises Borneolum Syntheticum, the amount that it is characterized in that Borneolum Syntheticum, the reactive systems that in the Olibanum is key component is that benchmark is 5-100% (weight), 20-30% (volume) preferably, more preferably about 25% (weight).
6, according to the described fragrant composition of arbitrary claim among the claim 1-3, it is characterized in that with the Olibanum being that the active aroma system of key component is that component by one or more Olibanum quintessence oils constitutes, its feature is that also it contains eucalyptole and perhaps Borneolum Syntheticum is as synergist, and its feature is that also its amount limits as follows:
About one or more the components of 15% (weight) of-1-from the Olibanum quintessence oil;
-2-about 85% (weight) eucalyptole,
In the 1+2 mixture is benchmark, and Borneolum Syntheticum perhaps can the highlyest be added to 25% (weight).
7, according to the described fragrant composition of arbitrary claim among the claim 1-6, it is characterized in that synergist contains at least a zinc salt and/or at least a mantoquita,
Its feature also is the metal cation of this salt or these salt, is that benchmark is 0.1-10% (weight) in the gross weight of aromatic substance, preferably 0.1-5% (weight).
8, according to the described fragrant composition of arbitrary claim among the claim 1-7, it is characterized in that this compositions contains at least a organic solvent that is selected from fat, alcohol, ether or their mixture, preferably be selected from alcohol/or ether, more preferably ethanol.
9,, it is characterized in that this compositions interpolation another component fragrant or non-fragrance at least according to the described fragrant composition of arbitrary claim among the claim 1-8.
10, the purposes of the described fragrant composition of arbitrary claim aspect preparation medicine, health product and hygienic article, cosmetics, spice, disinfectant, deodorizer, plant quarantine agent among the claim 1-9.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR94/12440 | 1994-10-13 | ||
| FR9412440A FR2725621A1 (en) | 1994-10-13 | 1994-10-13 | AROMATIC COMPOSITION AND ITS APPLICATIONS IN PARTICULAR IN PHARMACEUTICAL OR COSMETIC PRODUCTS, PERFUMES OR SANITARY AND HYGIENE PRODUCTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1160354A true CN1160354A (en) | 1997-09-24 |
Family
ID=9467974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95195632A Pending CN1160354A (en) | 1994-10-13 | 1995-10-11 | Fragrance composition and its use in particular in pharmaceuticals, cosmetics, fragrances or health products |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0788369A1 (en) |
| JP (1) | JPH11500466A (en) |
| CN (1) | CN1160354A (en) |
| AP (1) | AP707A (en) |
| AU (1) | AU3658395A (en) |
| CA (1) | CA2202554A1 (en) |
| FR (1) | FR2725621A1 (en) |
| OA (1) | OA10414A (en) |
| WO (1) | WO1996011694A2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108401420A (en) * | 2016-12-05 | 2018-08-14 | 郑汉洙 | The liquid phase deodorant compositions that odor prolongation is improved |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6379673B1 (en) * | 1997-12-08 | 2002-04-30 | Council Of Scientific And Industrial Research | Herbal formulation useful as a therapeutic and cosmetic applications for the treatment of general skin disorders |
| SG71877A1 (en) | 1997-12-19 | 2000-04-18 | Johnson & Johnson Consumer | Novel powder compositions |
| AU3765999A (en) * | 1998-06-29 | 2000-01-17 | Warner-Lambert Company | Improved oral compositions for control and prevention of tartar, oral malodor, plaque and gingivitis |
| US6346281B1 (en) | 2000-05-05 | 2002-02-12 | Scentsible Life Products, A Division Of Laid Back Designs Ltd. | Antimicrobial composition formulated with essential oils |
| JP4532706B2 (en) * | 2000-09-08 | 2010-08-25 | 花王株式会社 | Cosmetics |
| US8147877B2 (en) | 2006-06-01 | 2012-04-03 | Ohso Clean, Inc. | Essential oils based disinfecting compositions having tuberculocidal and fungicidal efficacies |
| US7465697B1 (en) | 2006-11-02 | 2008-12-16 | Ohsoclean, Inc. | Essential oils based cleaning and disinfecting compositions |
| CN102186341B (en) | 2008-10-20 | 2013-12-25 | 荷兰联合利华有限公司 | Antimicrobial composition |
| CN102510723B (en) | 2009-09-24 | 2016-08-10 | 荷兰联合利华有限公司 | Comprise the disinfectant of eugenol, terpinol and thymol |
| MX2013006435A (en) | 2010-12-07 | 2013-07-03 | Unilever Nv | An oral care composition. |
| WO2013064360A2 (en) | 2011-11-03 | 2013-05-10 | Unilever N.V. | A personal cleaning composition |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1018792B (en) * | 1987-06-30 | 1992-10-28 | 马德林 | Preparing method of a medicine externally used for preventing and treating cornary heart disease |
| JPH0757734B2 (en) * | 1990-10-09 | 1995-06-21 | 呉羽化学工業株式会社 | Sedative fragrance composition and cosmetics |
| CN1063819A (en) * | 1991-02-05 | 1992-08-26 | 王柱亭 | Formula of Kezeng ointment |
| CN1075888A (en) * | 1993-02-19 | 1993-09-08 | 孙秉华 | Medicine application for curing diarrhea |
-
1994
- 1994-10-13 FR FR9412440A patent/FR2725621A1/en active Granted
-
1995
- 1995-10-11 AU AU36583/95A patent/AU3658395A/en not_active Abandoned
- 1995-10-11 AP APAP/P/1997/000958A patent/AP707A/en active
- 1995-10-11 CA CA002202554A patent/CA2202554A1/en not_active Abandoned
- 1995-10-11 CN CN95195632A patent/CN1160354A/en active Pending
- 1995-10-11 JP JP8512981A patent/JPH11500466A/en active Pending
- 1995-10-11 EP EP95934198A patent/EP0788369A1/en not_active Withdrawn
- 1995-10-11 WO PCT/FR1995/001324 patent/WO1996011694A2/en not_active Application Discontinuation
-
1997
- 1997-04-11 OA OA60991A patent/OA10414A/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108401420A (en) * | 2016-12-05 | 2018-08-14 | 郑汉洙 | The liquid phase deodorant compositions that odor prolongation is improved |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2202554A1 (en) | 1996-04-25 |
| AP707A (en) | 1998-12-10 |
| OA10414A (en) | 2001-12-05 |
| WO1996011694A3 (en) | 1996-07-25 |
| AP9700958A0 (en) | 1997-04-30 |
| JPH11500466A (en) | 1999-01-12 |
| FR2725621B1 (en) | 1997-02-21 |
| AU3658395A (en) | 1996-05-06 |
| WO1996011694A2 (en) | 1996-04-25 |
| EP0788369A1 (en) | 1997-08-13 |
| FR2725621A1 (en) | 1996-04-19 |
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