CN116020660A - Nanometer magnetic bead separator - Google Patents
Nanometer magnetic bead separator Download PDFInfo
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Abstract
本发明公开了一种纳米磁珠分离器，包括试管架，试管架包括塑料支架以及磁体组件，塑料支架上设有若干列试管孔，试管孔内插有用于容置磁珠的试管，它还包括用于分离磁珠的磁体组件，所述磁体组件包括多个磁钢组合体，每个磁钢组合体与相应试管对应设置，且每个磁钢组合体的磁场对相应试管产生影响，以使得纳米磁珠分离至该试管侧壁。本发明的磁体组件包括多个磁钢组合体，每个磁钢组合体与相应试管对应设置，从而增强磁体组件的表磁强度，从而加快纳米磁珠的分离速率，提高纳米磁珠的分离效果。
The invention discloses a nano-magnetic bead separator, which comprises a test tube rack, the test tube rack includes a plastic bracket and a magnet assembly, a plurality of rows of test tube holes are arranged on the plastic bracket, and test tubes for accommodating magnetic beads are inserted in the test tube holes. It includes a magnet assembly for separating magnetic beads, the magnet assembly includes a plurality of magnetic steel assemblies, each magnetic steel assembly is arranged corresponding to a corresponding test tube, and the magnetic field of each magnetic steel assembly affects the corresponding test tube, so as to The magnetic nanobeads are separated to the side wall of the test tube. The magnet assembly of the present invention includes a plurality of magnetic steel assemblies, and each magnetic steel assembly is arranged corresponding to a corresponding test tube, thereby enhancing the surface magnetic strength of the magnet assembly, thereby accelerating the separation rate of nano magnetic beads and improving the separation effect of nano magnetic beads .
Description
技术领域technical field
本发明涉及分离设备技术领域，尤其涉及一种纳米磁珠分离器。The invention relates to the technical field of separation equipment, in particular to a nano magnetic bead separator.
背景技术Background technique
磁珠分离技术是一种基于以表面功能化的纳米磁珠为分离介质的新型分离方法，广泛应用于体外诊断、生物化工行业。其原理为：表面修饰了目标微生物抗体的磁珠由于抗体抗原的特异性反应形成磁珠微生物结合体，从而对外磁场敏感：磁珠微生物结合体被吸附，游离的杂质被去除，从而实现对目标物提纯和富集。利用到纳米磁珠进行核酸提取或蛋白质标记等，都依赖磁珠分离器。传统的磁珠分离装置多适合2m1体积的离心管使用，有些多功能磁力架适合2ml和15m1离心管使用，最大为50m1，但是分离式管直径越大，对纳米磁珠分离磁场场强要求越高，现有纳米磁珠分离器试管架采用单片烧结钕铁硼磁钢贴近试管的方式，表磁只有3000-4000GS，不仅分离速率慢，纳米磁珠分离效果也不好。Magnetic bead separation technology is a new separation method based on surface-functionalized nano-magnetic beads as the separation medium, which is widely used in in vitro diagnostics and biochemical industries. The principle is: the surface of the magnetic beads modified with the target microbial antibody is sensitive to the external magnetic field due to the specific reaction of the antibody antigen to form a magnetic bead microbial conjugate: the magnetic bead microbial conjugate is adsorbed, and the free impurities are removed, thereby realizing the goal. material purification and enrichment. The use of nano-magnetic beads for nucleic acid extraction or protein labeling relies on magnetic bead separators. Traditional magnetic bead separation devices are mostly suitable for centrifuge tubes with a volume of 2m1. Some multifunctional magnetic stands are suitable for 2ml and 15m1 centrifuge tubes, with a maximum of 50m1. High, the existing nano magnetic bead separator test tube rack adopts a single piece of sintered NdFeB magnet close to the test tube, the surface magnetism is only 3000-4000GS, not only the separation rate is slow, but the separation effect of nano magnetic beads is not good.
发明内容Contents of the invention
本申请通过提供一种纳米磁珠分离器，解决了现有技术中分离器的表磁强度弱，纳米磁珠分离速率慢以及分离效果不好的问题，实现了对磁体组件通过独特的拼接方法增强表磁强度，提高纳米磁珠的分离效率以及分离效果。By providing a nano-magnetic bead separator, the present application solves the problems of weak surface magnetic strength of the separator in the prior art, slow separation rate of nano-magnetic beads and poor separation effect, and realizes the unique splicing method of the magnet assembly. Enhance the surface magnetic strength, improve the separation efficiency and separation effect of nano magnetic beads.
为实现上述目的，本发明提供如下技术方案：一种纳米磁珠分离器，包括试管架，试管架包括塑料支架以及磁体组件，塑料支架上设有若干列试管孔，试管孔内插有用于容置磁珠的试管，它还包括用于分离磁珠的磁体组件，所述磁体组件包括多个磁钢组合体，每个磁钢组合体与相应试管对应设置，且每个磁钢组合体的磁场对相应试管产生影响，以使得纳米磁珠分离至该试管侧壁。In order to achieve the above object, the present invention provides the following technical solutions: a nano-magnetic bead separator, including a test tube rack, the test tube rack includes a plastic bracket and a magnet assembly, and the plastic bracket is provided with several columns of test tube holes, and the test tube holes are inserted for holding A test tube for placing magnetic beads, it also includes a magnet assembly for separating magnetic beads, the magnet assembly includes a plurality of magnetic steel assemblies, each magnetic steel assembly is correspondingly arranged with a corresponding test tube, and each magnetic steel assembly The magnetic field affects the corresponding test tube, so that the nano magnetic beads are separated to the side wall of the test tube.
通过采用上述技术方案，磁体组件包括多个磁钢组合体，每个磁钢组合体与相应试管对应设置，从而增强磁体组件的表磁强度，从而加快纳米磁珠的分离速率，提高纳米磁珠的分离效果。By adopting the above technical scheme, the magnet assembly includes a plurality of magnetic steel assemblies, and each magnetic steel assembly is arranged correspondingly to a corresponding test tube, thereby enhancing the surface magnetic strength of the magnet assembly, thereby accelerating the separation rate of nano-magnetic beads and improving the magnetic field of nano-magnetic beads. separation effect.
磁体组件包括第一磁体组件，第一磁体组件设于相邻两列试管孔之间，第一磁体组件包括多个条形磁钢组合体，每个条形磁钢组合体与同一行的试管孔对应，每个条形磁钢组合体的磁场对同一行相邻的试管产生影响。The magnet assembly includes a first magnet assembly, and the first magnet assembly is arranged between two adjacent columns of test tube holes. The first magnet assembly includes a plurality of bar-shaped magnetic steel assemblies, and each bar-shaped magnetic steel assembly is connected to the same row of test tubes. The holes correspond to each other, and the magnetic field of each bar-shaped magnetic-steel assembly affects the adjacent test tubes in the same row.
通过采用上述技术方案，通过在相邻两列试管孔之间设第一磁体组件，第一磁体组件可同时影响相邻两列试管，在保证试管受磁场影响的效果不变的同时节省了试管架的空间，体提高第一磁体组件的使用程度，第一磁体组件包括多个条形磁钢组合体，每个条形磁钢组合体与同一行的试管孔对应，同一行相邻两个试管共用同个条形磁钢组合，节约制造成本，也使得每个条形磁钢组合体的磁场对同一行相邻的试管单独产生影响，使得纳米磁珠分离至试管的一侧内壁处，保证了每个试管内磁珠的分离速率和分离效果。By adopting the above technical scheme, by setting the first magnet assembly between the test tube holes in two adjacent rows, the first magnet assembly can affect the test tubes in the two adjacent rows at the same time, saving the test tubes while ensuring that the effect of the test tubes being affected by the magnetic field remains unchanged. The space of the frame improves the utilization degree of the first magnet assembly. The first magnet assembly includes a plurality of bar-shaped magnetic-steel assemblies, each bar-shaped magnetic-steel assembly corresponds to the test tube holes in the same row, and two adjacent ones in the same row The test tubes share the same bar-shaped magnetic steel combination, which saves manufacturing costs, and also makes the magnetic field of each bar-shaped magnetic steel combination independently affect the adjacent test tubes in the same row, so that the nano-magnetic beads are separated to the inner wall of one side of the test tube. The separation rate and separation effect of the magnetic beads in each test tube are guaranteed.
条形磁钢组合体包括竖直设置且依次排列的第一辅助磁钢、第一磁芯、第二辅助磁钢、第二磁芯以及第三辅助磁钢，条形磁钢组合体的具体拼接方式如下：第一辅助磁钢与第三辅助磁钢的磁极方向相同，且第一辅助磁钢与第三辅助磁钢的磁极方向与条形磁钢组合体的中心轴平行，第二辅助磁钢的磁极方向与第一辅助磁钢的磁极方向相反；第一磁芯包括设于上端的第一磁冠、设于中端部的第一磁座、以及设于下端的第二磁冠，第一磁冠与第二磁冠的磁极方向相对而设，垂直中心轴，第一磁座包括竖直而设的两部分，且第一磁座的两部分的磁场方向背向而设，且第一磁座的两部分的磁场方向垂直于第一辅助磁钢的磁场方向；第二磁芯包括设于上端的第三磁冠、设于中端部的第二磁座、以及设于下端的第四磁冠，第三磁冠与第四磁冠的磁极方向背向而设，第二磁座包括竖直而设的两部分，且第二磁座的两部分的磁场方向相对而设，且第二磁座的两部分的磁场方向垂直于第一辅助磁钢的磁场方向。The bar-shaped magnetic steel assembly includes the first auxiliary magnetic steel, the first magnetic core, the second auxiliary magnetic steel, the second magnetic core and the third auxiliary magnetic steel, which are vertically arranged and arranged in sequence. The specific structure of the bar-shaped magnetic steel assembly is The splicing method is as follows: the magnetic pole directions of the first auxiliary magnetic steel and the third auxiliary magnetic steel are the same, and the magnetic pole directions of the first auxiliary magnetic steel and the third auxiliary magnetic steel are parallel to the central axis of the bar-shaped magnetic steel assembly, and the second auxiliary magnetic steel The magnetic pole direction of the magnetic steel is opposite to that of the first auxiliary magnetic steel; the first magnetic core includes a first magnetic crown at the upper end, a first magnetic seat at the middle end, and a second magnetic crown at the lower end , the magnetic pole directions of the first magnetic crown and the second magnetic crown are opposite to each other, perpendicular to the central axis, the first magnetic base includes two vertical parts, and the magnetic field directions of the two parts of the first magnetic base are opposite to each other, And the magnetic field direction of the two parts of the first magnetic base is perpendicular to the magnetic field direction of the first auxiliary magnetic steel; the second magnetic core includes the third magnetic crown located at the upper end, the second magnetic base located at the middle end, and the The fourth magnetic crown at the lower end, the third magnetic crown and the magnetic pole direction of the fourth magnetic crown are arranged in the opposite direction, the second magnetic base includes two vertical parts, and the magnetic field directions of the two parts of the second magnetic base are opposite to each other. Assume that, and the direction of the magnetic field of the two parts of the second magnetic base is perpendicular to the direction of the magnetic field of the first auxiliary magnet.
通过采用上述技术方案，第一磁座的两部分的磁场方向背向而设，第二磁座的两部分的磁场方向相对而设，其余磁钢共用的方式，节省空间节约制造成本，通过条形磁钢组合体中的各个磁钢的磁场方向的角度设置，实现对相邻两侧试管的连接处实现磁场增强，通过增强的磁场可实现纳米磁珠快速高效的分离，使得纳米磁珠分离至试管的一侧内壁处。By adopting the above-mentioned technical scheme, the magnetic field directions of the two parts of the first magnetic base are arranged opposite to each other, and the magnetic field directions of the two parts of the second magnetic base are oppositely arranged, and the rest of the magnetic steels are shared, which saves space and saves manufacturing costs. The angle setting of the magnetic field direction of each magnetic steel in the shaped magnetic steel assembly realizes the magnetic field enhancement at the connection of the test tubes on both adjacent sides. The enhanced magnetic field can realize the rapid and efficient separation of nano magnetic beads, making the separation of nano magnetic beads to the inner wall of one side of the test tube.
第一磁芯以及第二磁芯的设立位置与试管的设立位置对应，第一磁芯与试管的连接处设有第一弧面，第二磁芯与试管的连接处设有第二弧面，第一弧面与第二弧面与所述试管相配合。The establishment positions of the first magnetic core and the second magnetic core correspond to the establishment positions of the test tube, the connection between the first magnetic core and the test tube is provided with a first arc surface, and the connection between the second magnetic core and the test tube is provided with a second arc surface , the first arc surface and the second arc surface match with the test tube.
通过采用上述技术方案，通过第一磁芯与试管的连接处设有第一弧面，第二磁芯与试管的连接处设有第二弧面，能够使第一磁芯与第二磁芯更好的贴合外壁，提高分离器的分离纳米磁珠的效率。By adopting the above-mentioned technical scheme, the connection between the first magnetic core and the test tube is provided with a first arc surface, and the connection between the second magnetic core and the test tube is provided with a second arc surface, which can make the first magnetic core and the second magnetic core Better fit the outer wall and improve the efficiency of the separator for separating nano magnetic beads.
磁体组件包括第二磁体组件，第二磁体组件包括多个环形磁钢组合体，环形磁钢组合体设于塑料支架上且位于试管孔的下方，每个环形磁钢组合体与每个试管孔对应且同轴设置，试管通过试管孔插接于环形磁钢组合体的中心轴处，每个环形磁钢组合体的磁场对相应的试管产生影响。The magnet assembly includes a second magnet assembly, the second magnet assembly includes a plurality of ring-shaped magnet steel assemblies, the ring-shaped magnet steel assemblies are arranged on the plastic support and below the test tube holes, each ring magnet steel assembly is connected to each test tube hole Correspondingly and coaxially arranged, the test tube is plugged into the central axis of the annular magnetic steel assembly through the test tube hole, and the magnetic field of each annular magnetic steel assembly affects the corresponding test tube.
通过采用上述技术方案，试管通过试管孔插接于环形磁钢组合体的中心轴，每个环形磁钢组合体影响一个试管，使试管受到环形磁钢组合体的磁场效果增强，从而提高纳米磁珠的分离效率。By adopting the above technical scheme, the test tube is inserted into the central axis of the ring magnet steel assembly through the test tube hole, and each ring magnet steel assembly affects a test tube, so that the test tube is subjected to the magnetic field effect of the ring magnet steel assembly. Bead Separation Efficiency.
环形磁钢组合体包括若干磁瓦，磁瓦呈条状，且环形磁钢组合体由磁瓦拼接而成，环形磁钢组合体的拼接方式有多种。The annular magnetic steel assembly includes several magnetic tiles, the magnetic tiles are in the shape of strips, and the annular magnetic steel assembly is spliced by the magnetic tiles, and there are many ways of splicing the annular magnetic steel assembly.
通过采用上述技术方案，通过若干磁瓦拼接成环形磁钢组合体，通过不同磁瓦的磁场的影响，从而达到增强对试管的磁场影响，从而使得试管内的纳米磁珠的分离速率和分离效果得到增强。By adopting the above technical scheme, several magnetic tiles are spliced into a ring-shaped magnetic steel assembly, and through the influence of the magnetic fields of different magnetic tiles, the influence of the magnetic field on the test tube can be enhanced, so that the separation rate and separation effect of the nano-magnetic beads in the test tube can be achieved. be enhanced.
环形磁钢组合体的第一种拼接方式为第一环形磁钢，第一环形磁钢包括十二片形状相同的磁瓦，第一环形磁钢由十二片磁瓦拼接而成，相对设置的磁瓦的磁场方向相同，且相邻四块磁瓦的第一块磁瓦的磁场方向沿第一环形磁钢的顺时针方向顺时针旋转180°成为第四块磁瓦的磁场方向，使第一环形磁钢的磁场内径方向两极得到增强。The first splicing method of the ring magnet assembly is the first ring magnet. The first ring magnet includes twelve pieces of magnetic tiles with the same shape. The first ring magnet is spliced by twelve pieces of magnet tiles. The magnetic field direction of the magnetic tiles is the same, and the magnetic field direction of the first magnetic tile of the four adjacent magnetic tiles rotates clockwise 180° clockwise along the clockwise direction of the first ring magnet to become the magnetic field direction of the fourth magnetic tile, so that The two poles in the inner diameter direction of the magnetic field of the first ring magnet are strengthened.
通过采用上述技术方案，第一环形磁钢的磁场内径方向两极得到增强，使得试管内的磁珠可在试管的两极侧壁处分离，通过上述方法可提高试管内磁珠的分离速率和分离效果。By adopting the above technical scheme, the two poles in the inner diameter direction of the magnetic field of the first ring magnet are strengthened, so that the magnetic beads in the test tube can be separated at the side walls of the two poles of the test tube, and the separation rate and separation effect of the magnetic beads in the test tube can be improved by the above method .
环形磁钢组合体的第二种拼接方式为第二环形磁钢，第二环形磁钢包括八片形状相同的磁瓦，第二环形磁钢由八片磁瓦拼接而成，相对设置的磁瓦的磁场方向相对，且相邻三块磁瓦的第一块磁瓦的磁场方向沿第二环形磁钢的顺时针方向逆时针旋转90°成为第三块磁瓦的磁场方向,使第二环形磁钢的磁场内径方向四极得到增强。The second splicing method of the ring magnet assembly is the second ring magnet. The second ring magnet includes eight magnet tiles of the same shape. The second ring magnet is spliced by eight magnet tiles. The magnetic field directions of the tiles are opposite, and the magnetic field direction of the first magnetic tile of the three adjacent magnetic tiles is rotated 90° counterclockwise along the clockwise direction of the second ring magnet to become the magnetic field direction of the third magnetic tile, so that the second The quadrupole in the inner diameter direction of the magnetic field of the ring magnet is strengthened.
通过采用上述技术方案，第二环形磁钢的磁场内径方向四极得到增强，使得试管内的磁珠可在试管的四极侧壁处分离，通过上述方法可提高试管内磁珠的分离速率和分离效果。By adopting the above-mentioned technical scheme, the quadrupoles in the inner diameter direction of the magnetic field of the second annular magnetic steel are strengthened, so that the magnetic beads in the test tube can be separated at the quadrupole sidewall of the test tube, and the separation rate and the separation rate of the magnetic beads in the test tube can be improved by the method seperate effect.
环形磁钢组合体的第三种拼接方式为第三环形磁钢，第三环形磁钢包括十二片形状相同的磁瓦，第三环形磁钢由十二片磁瓦拼接而成，相对设置的磁瓦的磁场方向相同,且相邻四块磁瓦的第一块磁瓦的磁场方形沿第三环形磁钢的顺时针方向顺时针旋转360°成为第四块磁瓦的磁场方向，使第三环形磁钢的磁场内径方向六极得到增强。The third splicing method of the ring magnet assembly is the third ring magnet. The third ring magnet includes twelve pieces of magnet tiles with the same shape. The third ring magnet is spliced by twelve pieces of magnet tiles. The magnetic field directions of the magnetic tiles are the same, and the magnetic field square of the first magnetic tile of the four adjacent magnetic tiles rotates 360° clockwise along the clockwise direction of the third ring magnet to become the magnetic field direction of the fourth magnetic tile, so that The six poles in the inner diameter direction of the magnetic field of the third ring magnet are strengthened.
通过采用上述技术方案，第三环形磁钢的磁场内径方向六极得到增强，使得试管内的磁珠可在试管的六级侧壁处分离，通过上述方法可提高试管内磁珠的分离速率和分离效果。By adopting the above technical scheme, the six poles in the inner diameter direction of the magnetic field of the third annular magnetic steel are strengthened, so that the magnetic beads in the test tube can be separated at the six-stage side wall of the test tube, and the separation rate and seperate effect.
附图说明Description of drawings
图1为本发明的实施例一的结构示意图；FIG. 1 is a schematic structural view of
图2为本发明的实施例一的第一磁体组件的结构示意图；2 is a schematic structural view of a first magnet assembly according to
图3为本发明的实施例一的剖面结构示意图；FIG. 3 is a schematic cross-sectional structure diagram of
图4为本发明的实施例一的侧板的结构示意图；Fig. 4 is a schematic structural view of a side plate of
图5为本发明的实施例一的条形磁钢组合体的结构示意图；Fig. 5 is a schematic structural view of a strip-shaped magnetic steel assembly according to
图6为本发明的实施例二的结构示意图；6 is a schematic structural diagram of
图7为本发明的实施例二的底板的结构示意图；FIG. 7 is a schematic structural view of the bottom plate of
图8为本发明的实施例二的第一环形磁钢的结构示意图；FIG. 8 is a schematic structural view of the first ring magnet in
图9为本发明的实施例二的第一环形磁钢的磁场方向以及各个磁瓦的磁场方向的结构示意图；Fig. 9 is a structural schematic diagram of the magnetic field direction of the first ring magnet and the magnetic field direction of each magnetic tile according to the second embodiment of the present invention;
图10为本发明的实施例二的第二环形磁钢的结构示意图；Fig. 10 is a schematic structural view of a second ring magnet according to
图11为本发明的实施例二的第二环形磁钢的磁场方向以及各个磁瓦的磁场方向的结构示意图；Fig. 11 is a structural schematic diagram of the magnetic field direction of the second ring magnet and the magnetic field direction of each magnetic tile according to the second embodiment of the present invention;
图12为本发明的实施例二的第三环形磁钢的结构示意图；Fig. 12 is a schematic structural view of a third ring magnet according to
图13为本发明的实施例二的第三环形磁钢的磁场方向以及各个磁瓦的磁场方向的结构示意图。Fig. 13 is a structural schematic view of the magnetic field direction of the third ring magnet and the magnetic field direction of each magnetic tile according to the second embodiment of the present invention.
图中：1、塑料支架；1.1、底板；1.1.1、定位孔；1.2、顶板；1.2.1、试管孔；1.3、侧板；1.3.1、凹槽；2、第一磁体组件；2.1、条形磁钢组合体；2.1.1、第一辅助磁钢；2.1.2、第二辅助磁钢；2.1.3、第三辅助磁钢；2.1.4、第一磁芯；2.1.4.1、第一磁冠；2.1.4.2、第一磁座；2.1.4.3、第二磁冠；2.1.4.4、第一弧面；2.1.5、第二磁芯；2.1.5.1、第三磁冠；2.1.5.2、第二磁座；2.1.5.3、第四磁冠；2.1.5.4、第二弧面；3、第二磁体组件；3.1、环形磁钢组合体；3.1.1、第一环形磁钢；3.1.2、第二环形磁钢；3.1.3、第三环形磁钢；4、试管。In the figure: 1, plastic bracket; 1.1, bottom plate; 1.1.1, positioning hole; 1.2, top plate; 1.2.1, test tube hole; 1.3, side plate; 1.3.1, groove; 2, first magnet assembly; 2.1 , bar magnet assembly; 2.1.1, the first auxiliary magnet; 2.1.2, the second auxiliary magnet; 2.1.3, the third auxiliary magnet; 2.1.4, the first magnetic core; 2.1.4.1 , the first magnetic crown; 2.1.4.2, the first magnetic seat; 2.1.4.3, the second magnetic crown; 2.1.4.4, the first arc surface; 2.1.5, the second magnetic core; 2.1.5.1, the third magnetic crown ; 2.1.5.2, the second magnetic seat; 2.1.5.3, the fourth magnetic crown; 2.1.5.4, the second arc surface; 3, the second magnet assembly; 3.1, the ring magnet assembly; 3.1.1, the first ring Magnet; 3.1.2, second ring magnet; 3.1.3, third ring magnet; 4, test tube.
具体实施方式Detailed ways
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.
实施例一：Embodiment one:
请参阅图1-5所示，在本实施方案中：一种纳米磁珠分离器，包括试管架，所述的试管架包括塑料支架1以及磁体组件，所述的塑料支架1上设有若干列试管孔1.2.1，所述的试管孔1.2.1内插有用于容置磁珠的试管4，其特征在于：它还包括用于分离磁珠的磁体组件，所述磁体组件包括多个磁钢组合体，每个磁钢组合体与相应试管4对应设置，且每个磁钢组合体的磁场对相应试管4产生影响，以使得纳米磁珠分离至该试管4侧壁。Please refer to shown in Fig. 1-5, in this embodiment: a kind of nano-magnetic bead separator, comprises test tube holder, and described test tube holder comprises
上述本申请实施例中的技术方案，至少具有如下的技术效果或优点：磁体组件包括多个磁钢组合体，每个磁钢组合体与相应试管4对应设置，从而增强磁体组件的表磁强度，从而加快纳米磁珠的分离速率，提高纳米磁珠的分离效果。The above-mentioned technical solutions in the embodiments of the present application have at least the following technical effects or advantages: the magnet assembly includes a plurality of magnet steel assemblies, and each magnet assembly is correspondingly arranged with a
磁体组件包括第一磁体组件2，第一磁体组件2设于相邻两列试管孔1.2.1之间，第一磁体组件2包括多个条形磁钢组合体2.1，每个条形磁钢组合体2.1与同一行的试管孔1.2.1对应，每个条形磁钢组合体2.1的磁场对同一行相邻的试管4产生影响。The magnet assembly includes a
上述本申请实施例中的技术方案，至少具有如下的技术效果或优点：通过在相邻两列试管孔1.2.1之间设第一磁体组件2，第一磁体组件2可同时影响相邻两列试管4，在保证试管4受磁场影响的效果不变的同时节省了试管架的空间，提高第一磁体组件2的使用程度，第一磁体组件2包括多个条形磁钢组合体2.1，每个条形磁钢组合体2.1与同一行的试管孔1.2.1对应，同一行相邻两个试管4共用同个条形磁钢组合，节约制造成本，也使得每个条形磁钢组合体2.1的磁场对同一行相邻的试管4单独产生影响，使得纳米磁珠分离至试管4的一侧内壁处，保证了每个试管4内磁珠的分离速率和分离效果。The above-mentioned technical solution in the embodiment of the present application has at least the following technical effects or advantages: by setting the
塑料支架1包括底板1.1、设于底板1.1上方的顶板1.2、以及设于底板1.1与顶板1.2之间用于支撑顶板1.2两块侧板1.3，两块侧板1.3呈相对设置，试管孔1.2.1设于顶板1.2上，底板1.1上设有与试管孔1.2.1对应的定位孔1.1.1，且定位孔1.1.1与试管孔1.2.1呈同轴设置。The
上述本申请实施例中的技术方案，至少具有如下的技术效果或优点：试管4通过试管孔1.2.1设于定位孔1.1.1内，通过试管孔1.2.1与定位孔1.1.1同轴设置，定位孔1.1.1可以更好的精确固定试管4位置。The technical solution in the above-mentioned embodiment of the present application has at least the following technical effects or advantages: the
侧板1.3侧面设有凹槽1.3.1，第一磁体组件2的两端分别设于相对设置的侧板1.3的凹槽1.3.1内。A groove 1.3.1 is provided on the side of the side plate 1.3, and the two ends of the
上述本申请实施例中的技术方案，至少具有如下的技术效果或优点：相对的侧板1.3设有凹槽1.3.1，且第一磁体组件2的两端设于凹槽1.3.1内，能够限制第一磁体组件2的水平移动。The above-mentioned technical solution in the embodiment of the present application has at least the following technical effects or advantages: the opposite side plate 1.3 is provided with a groove 1.3.1, and the two ends of the
条形磁钢组合体2.1包括竖直设置且依次排列的第一辅助磁钢2.1.1、第一磁芯2.1.4、第二辅助磁钢2.1.2、第二磁芯2.1.5以及第三辅助磁钢2.1.3，条形磁钢组合体2.1的具体拼接方式如下：第一辅助磁钢2.1.1与第三辅助磁钢2.1.3的磁极方向相同，且第一辅助磁钢2.1.1与第三辅助磁钢2.1.3的磁极方向与条形磁钢组合体2.1的中心轴平行，第二辅助磁钢2.1.2的磁极方向与第一辅助磁钢2.1.1的磁极方向相反；第一磁芯2.1.4包括设于上端的第一磁冠2.1.4.1、设于中端部的第一磁座2.1.4.2、以及设于下端的第二磁冠2.1.4.3，第一磁冠2.1.4.1与第二磁冠2.1.4.3的磁极方向相对而设，垂直于中心轴，第一磁座2.1.4.2包括竖直而设的两部分，且第一磁座2.1.4.2的两部分的磁场方向背向而设，且第一磁座2.1.4.2的两部分的磁场方向垂直于第一辅助磁钢2.1.1的磁场方向；第二磁芯2.1.5包括设于上端的第三磁冠2.1.5.1、设于中端部的第二磁座2.1.5.2、以及设于下端的第四磁冠2.1.5.3，第三磁冠2.1.5.1与第四磁冠2.1.5.3的磁极方向背向而设，第二磁座2.1.5.2包括竖直而设的两部分，且第二磁座2.1.5.2的两部分的磁场方向相对而设，且第二磁座2.1.5.2的两部分的磁场方向垂直于第一辅助磁钢2.1.1的磁场方向。The strip magnetic steel assembly 2.1 includes the first auxiliary magnetic steel 2.1.1, the first magnetic core 2.1.4, the second auxiliary magnetic steel 2.1.2, the second magnetic core 2.1.5 and the first auxiliary magnetic steel 2.1.1 arranged vertically and arranged in sequence. The specific splicing method of the three auxiliary magnets 2.1.3 and the strip magnet assembly 2.1 is as follows: the magnetic pole directions of the first auxiliary magnet 2.1.1 and the third auxiliary magnet 2.1.3 are the same, and the first auxiliary magnet 2.1 .1 The magnetic pole direction of the third auxiliary magnetic steel 2.1.3 is parallel to the central axis of the strip magnetic steel assembly 2.1, the magnetic pole direction of the second auxiliary magnetic steel 2.1.2 is parallel to the magnetic pole direction of the first auxiliary magnetic steel 2.1.1 On the contrary; the first magnetic core 2.1.4 includes the first magnetic crown 2.1.4.1 located at the upper end, the first magnetic seat 2.1.4.2 located at the middle end, and the second magnetic crown 2.1.4.3 located at the lower end. A magnetic crown 2.1.4.1 is set opposite to the magnetic pole direction of the second magnetic crown 2.1.4.3, perpendicular to the central axis, the first magnetic base 2.1.4.2 includes two vertical parts, and the first magnetic base 2.1.4.2 The magnetic field directions of the two parts of the first magnetic base 2.1.4.2 are arranged opposite to each other, and the magnetic field directions of the two parts of the first magnetic base 2.1.4.2 are perpendicular to the magnetic field direction of the first auxiliary magnetic steel 2.1.1; the second magnetic core 2.1.5 includes a The third magnetic crown 2.1.5.1, the second magnetic seat 2.1.5.2 located at the middle end, and the fourth magnetic crown 2.1.5.3 located at the lower end, the third magnetic crown 2.1.5.1 and the fourth magnetic crown 2.1. The direction of the magnetic pole of 5.3 is set facing away, and the second magnetic base 2.1.5.2 includes two vertical parts, and the magnetic field directions of the two parts of the second magnetic base 2.1.5.2 are opposite, and the second magnetic base 2.1. The magnetic field direction of the two parts of 5.2 is perpendicular to the magnetic field direction of the first auxiliary magnetic steel 2.1.1.
上述本申请实施例中的技术方案，至少具有如下的技术效果或优点：第一磁座2.1.4.2的两部分的磁场方向背向而设，第二磁座2.1.5.2的两部分的磁场方向相对而设，其余磁钢共用的方式，节省空间节约制造成本，通过条形磁钢组合体2.1中的各个磁钢的磁场方向的角度设置，实现对相邻两侧试管4的连接处实现磁场增强，通过增强的磁场可实现纳米磁珠快速高效的分离，使得纳米磁珠分离至试管4的一侧内壁处。The above-mentioned technical solutions in the embodiments of the present application have at least the following technical effects or advantages: the magnetic field directions of the two parts of the first magnetic base 2.1.4.2 are arranged opposite to each other, and the magnetic field directions of the two parts of the second magnetic base 2.1.5.2 Relatively, the other magnetic steels are shared, which saves space and saves manufacturing costs. By setting the angle of the magnetic field direction of each magnetic steel in the bar-shaped magnetic steel assembly 2.1, the magnetic field can be realized at the joints of the
第一磁芯2.1.4以及第二磁芯2.1.5的设立位置与试管4的设立位置对应，第一磁芯2.1.4与试管4的连接处设有第一弧面2.1.4.4，第二磁芯2.1.5与试管4的连接处设有第二弧面2.1.5.4，第一弧面2.1.4.4与第二弧面2.1.5.4与所述试管4相配合。The establishment position of the first magnetic core 2.1.4 and the second magnetic core 2.1.5 corresponds to the establishment position of the
上述本申请实施例中的技术方案，至少具有如下的技术效果或优点：通过第一磁芯2.1.4与试管4的连接处设有第一弧面2.1.4.4，第二磁芯2.1.5与试管4的连接处设有第二弧面2.1.5.4，能够使第一磁芯2.1.4与第二磁芯2.1.5更好的贴合外壁，提高分离器的分离纳米磁珠的效率。The above-mentioned technical solutions in the embodiments of the present application have at least the following technical effects or advantages: the connection between the first magnetic core 2.1.4 and the
实施例二：Embodiment two:
请参阅图6-13所示，在本实施方案中：一种纳米磁珠分离器，包括试管架，试管架包括塑料支架1以及第二磁体组件3，塑料支架1上设有若干列试管孔1.2.1，试管孔1.2.1内插有试管4，第二磁体组件3包括若干个环形磁钢组合体3.1，环形磁钢组合体3.1设于塑料支架1上且位于试管孔1.2.1的下方，每个环形磁钢组合体3.1与每个试管孔1.2.1对应且同轴设置，试管4通过试管孔1.2.1插接于环形磁钢组合体3.1的中心轴处，每个环形磁钢组合体3.1的磁场对相应的试管4产生影响。Please refer to shown in Fig. 6-13, in this embodiment: a kind of nano-magnetic bead separator, comprises test tube rack, and test tube rack comprises
上述本申请实施例中的技术方案，至少具有如下的技术效果或优点：试管4通过试管孔1.2.1插接于环形磁钢组合体3.1的中心轴，每个环形磁钢组合体3.1影响一个试管4，使试管4受到环形磁钢组合体3.1的磁场效果增强，从而提高纳米磁珠的分离效率。The above-mentioned technical solution in the embodiment of the present application has at least the following technical effects or advantages: the
塑料支架1包括底板1.1、设于底板1.1上方的顶板1.2、以及设于底板1.1与顶板1.2之间用于支撑顶板1.2两块侧板1.3，两块侧板1.3呈相对设置，试管孔1.2.1设于顶板1.2上，底板1.1上设有与试管孔1.2.1对应的定位孔1.1.1，且定位孔1.1.1与试管孔1.2.1呈同轴设置。The
上述本申请实施例中的技术方案，至少具有如下的技术效果或优点：试管4通过试管孔1.2.1设于定位孔1.1.1内，通过试管孔1.2.1与定位孔1.1.1同轴设置，定位孔1.1.1可以更好的精确固定试管4位置。The technical solution in the above-mentioned embodiment of the present application has at least the following technical effects or advantages: the
环形磁钢组合体3.1包括若干磁瓦，磁瓦呈条状，且环形磁钢组合体3.1由磁瓦拼接而成，环形磁钢组合体3.1的拼接方式有三种：环形磁钢组合体3.1的第一种拼接方式为第一环形磁钢3.1.1，第一环形磁钢3.1.1包括十二片形状相同的磁瓦，第一环形磁钢3.1.1由十二片磁瓦拼接而成，相对设置的磁瓦的磁场方向相同，相邻四块磁瓦的第一块磁瓦的磁场方向沿第一环形磁钢3.1.1的顺时针方向顺时针旋转180°成为第四块磁瓦的磁场方向，使第一环形磁钢3.1.1的磁场内径方向两极得到增强；环形磁钢组合体3.1的第二种拼接方式为第二环形磁钢3.1.2，第二环形磁钢3.1.2包括八片形状相同的磁瓦，第二环形磁钢3.1.2由八片磁瓦拼接而成，相对设置的磁瓦的磁场方向相对，且相邻三块磁瓦的第一块磁瓦的磁场方向沿第二环形磁钢3.1.2的顺时针方向逆时针旋转90°成为第三块磁瓦的磁场方向,使第二环形磁钢3.1.2的磁场内径方向四极得到增强；环形磁钢组合体3.1的第三种拼接方式为第三环形磁钢3.1.3，第三环形磁钢3.1.3包括十二片形状相同的磁瓦，第三环形磁钢3.1.3由十二片磁瓦拼接而成，相对设置的磁瓦的磁场方向相同,且相邻四块磁瓦的第一块磁瓦的磁场方形沿第三环形磁钢3.1.3的顺时针方向顺时针旋转360°成为第四块磁瓦的磁场方向，使第三环形磁钢3.1.3的磁场内径方向六极得到增强。The annular magnetic steel assembly 3.1 includes several magnetic tiles, the magnetic tiles are in the shape of strips, and the annular magnetic steel assembly 3.1 is spliced by the magnetic tiles. There are three ways of splicing the annular magnetic steel assembly 3.1: the ring magnetic steel assembly 3.1 The first splicing method is the first ring magnet 3.1.1. The first ring magnet 3.1.1 includes twelve magnetic tiles with the same shape. The first annular magnet 3.1.1 is spliced by twelve tiles. , the magnetic field directions of the oppositely arranged magnetic tiles are the same, and the magnetic field direction of the first magnetic tile of the four adjacent magnetic tiles rotates 180° clockwise along the clockwise direction of the first ring magnet 3.1.1 to become the fourth magnetic tile The magnetic field direction of the first ring magnet 3.1.1 is strengthened at the two poles in the inner diameter direction of the magnetic field; the second splicing method of the ring magnet assembly 3.1 is the second ring magnet 3.1.2, and the second ring magnet 3.1. 2. It includes eight magnetic tiles with the same shape. The second annular magnetic steel 3.1.2 is spliced by eight magnetic tiles. The magnetic field directions of the opposite magnetic tiles are opposite, and the first magnetic tile of the three adjacent magnetic tiles The magnetic field direction of the second annular magnetic steel 3.1.2 is rotated 90° counterclockwise along the clockwise direction to become the magnetic field direction of the third magnetic tile, so that the quadrupole in the inner diameter direction of the magnetic field of the second annular magnetic steel 3.1.2 is strengthened; The third splicing method of the magnetic steel assembly 3.1 is the third annular magnetic steel 3.1.3, the third annular magnetic steel 3.1.3 includes twelve magnetic tiles with the same shape, and the third annular magnetic steel 3.1.3 consists of twelve The magnetic tiles are spliced together, and the magnetic field directions of the opposite magnetic tiles are the same, and the magnetic field square of the first magnetic tile of the four adjacent magnetic tiles rotates 360 clockwise along the clockwise direction of the third ring magnetic steel 3.1.3 ° becomes the magnetic field direction of the fourth magnetic tile, so that the six poles in the inner diameter direction of the magnetic field of the third annular magnetic steel 3.1.3 are strengthened.
上述本申请实施例中的技术方案，至少具有如下的技术效果或优点：，第一环形磁钢3.1.1的磁场内径方向两极得到增强，使得试管4内的磁珠可在试管4的两极侧壁处分离；第二环形磁钢3.1.2的磁场内径方向四极得到增强，使得试管4内的磁珠可在试管4的四极侧壁处分离；第三环形磁钢3.1.3的磁场内径方向六极得到增强，使得试管4内的磁珠可在试管4的六级侧壁处分离，通过上述方法均可提高试管4内磁珠的分离速率和分离效果。The technical solution in the above-mentioned embodiment of the present application has at least the following technical effects or advantages: the two poles in the inner diameter direction of the magnetic field of the first ring magnet 3.1. The wall is separated; the quadrupole in the inner diameter direction of the magnetic field of the second ring magnet 3.1.2 is strengthened, so that the magnetic beads in the
以上仅就本发明的最佳实施例作了说明，但不能理解为是对权利要求的限制。本发明不仅局限于以上实施例，其具体结构允许有变化。凡在本发明独立权利要求的保护范围内所作的各种变化均在本发明保护范围内。The above are only descriptions of the preferred embodiments of the present invention, but should not be construed as limiting the claims. The present invention is not limited to the above embodiments, and its specific structure is allowed to vary. All changes made within the protection scope of the independent claims of the present invention are within the protection scope of the present invention.
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